Aliases for DLST Gene
- Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex, Mitochondrial 3
- Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex 4
- 2-Oxoglutarate Dehydrogenase Complex Component E2 4
- Dihydrolipoyllysine-Residue Succinyltransferase 2
- EC 2.3.1 61
External Ids for DLST Gene
Previous HGNC Symbols for DLST Gene
Previous GeneCards Identifiers for DLST Gene
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for DLST Gene
DLST (Dihydrolipoamide S-Succinyltransferase) is a Protein Coding gene. Diseases associated with DLST include Alpha-Ketoglutarate Dehydrogenase Deficiency and Wernicke-Korsakoff Syndrome. Among its related pathways are Glyoxylate metabolism and glycine degradation and Citrate cycle (TCA cycle). GO annotations related to this gene include transferase activity and dihydrolipoyllysine-residue succinyltransferase activity. An important paralog of this gene is DBT.
UniProtKB/Swiss-Prot for DLST Gene
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).