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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLST Gene

protein-coding   GIFtS: 64
GCID: GC14P075348

dihydrolipoamide S-succinyltransferase (E2 component of...


(Previous symbol: DLTS)
 Explore 17 diseases affiliated with
DLST via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DLST    

Aliases
for DLST gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dihydrolipoamide S-Succinyltransferase (E2 Component Of 2-Oxo-Glutarate
Complex)1 2
     Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate
Dehydrogenase Complex, Mitochondrial2
DLTS1 2 3     2-Oxoglutarate Dehydrogenase Complex Component E23
E2K2 3     Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase
Complex3
OGDC-E22 3     EC 2.3.18
EC 2.3.1.613 8     

External Ids:    HGNC: 29111   Entrez Gene: 17432   Ensembl: ENSG000001196897   OMIM: 1260635   UniProtKB: P369573   
ORGUL members:         
NONCODE:n409414    

Export aliases for DLST gene to outside databases

Previous GC identifers: GC14P072875 GC14P069166 GC14P073338 GC14P074418 GC14P055516


Summaries
for DLST gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DLST:
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of
the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall
conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for
this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA
and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide
succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Wiki entry for DLST


Genomic Views
for DLST gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLST gene promoter:
         Sp1   AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   C/EBPalpha   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLST promoter sequence
   Search SABiosciences Chromatin IP Primers for DLST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q23.1

DLST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLST gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075348:  view genomic region     (about GC identifiers)

Start:
 75,348,594 bp from pter      End:
 75,370,450 bp from pter
Size:
 21,857 bases      Orientation:
 plus strand

Proteins
for DLST gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957 (See protein sequence)
Recommended Name: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex,
mitochondrial precursor  
Size: 453 amino acids; 48755 Da
Cofactor: Binds 1 lipoyl cofactor covalently
Subunit: Forms a 24-polypeptide structural core with octahedral symmetry
Subcellular location: Mitochondrion
Secondary accessions: Q7LDY7 Q9BQ32

Explore the universe of human proteins at neXtProt for DLST: NX_P36957

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P36957

    • 4/17 DME Specific Peptides for DLST (P36957) (see all 17)
     VPVIRNV  GTFTISN  SVAVATP  GLVVPVIR 

    DLST Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231812.1  NP_001924.2  

    ENSEMBL proteins: 
     ENSP00000451210   ENSP00000335304   ENSP00000452417   ENSP00000451670   ENSP00000238671  
     ENSP00000452422   ENSP00000451957   ENSP00000451425   ENSP00000335465  
    Reactome Protein details: P36957
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: DLST
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    Novus Biologicals DLST Proteins
    Novus Biologicals DLST Lysates
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    ProSpec Recombinant Protein for DLST
    Uscn Proteins for DLST

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--
    GO:0005792microsome ----


    DLST for ontologies           About GeneDecksing



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    ThermoFisher Antibody for DLST

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    Uscn ELISAs and CLIAs for DLST

    Protein Domains /
    Families
    for DLST gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DLST for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR006255 SucB
     IPR011053 Single_hybrid_motif
     IPR000089 Biotin_lipoyl
     IPR003016 2-oxoA_DH_lipoyl-BS
     IPR001078 2-oxoacid_DH_actylTfrase

    Graphical View of Domain Structure for InterPro Entry P36957

    ProtoNet protein and cluster: P36957

    3 Blocks protein families:
    IPB000089 Biotin/lipoyl attachment
    IPB001078 Catalytic domain of components of various dehydrogenase complexes
    IPB003016 2-oxo acid dehydrogenase


    UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
    Similarity: Belongs to the 2-oxoacid dehydrogenase family
    Similarity: Contains 1 lipoyl-binding domain


    Function
    for DLST gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
    Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA
    and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide
    succinyltransferase (E2) and lipoamide dehydrogenase (E3)
    Catalytic activity: Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme
    N(6)-(S-succinyldihydrolipoyl)lysine

         Genatlas biochemistry entry for DLST:
    dihydrolipoamide S-succinyltransferase

    Enzyme Numbers (IUBMB): EC 2.3.1.611 2 EC 2.3.12

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DLST
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLST
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate DLST (see all 37):
    hsa-miR-124* hsa-let-7d hsa-miR-15a hsa-miR-938 hsa-miR-218 hsa-miR-29b-1* hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: DLST 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLST (see all 7)
    OriGene shRNA RFP: DLST
    OriGene siRNA: DLST
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLST

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DLST

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLST (see all 3)
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004149dihydrolipoyllysine-residue succinyltransferase activity IEA--
    GO:0016740transferase activity ----
    GO:0016746transferase activity, transferring acyl groups ----
    GO:0031072heat shock protein binding ----
    GO:0051087chaperone binding ----


    DLST for ontologies           About GeneDecksing


    Animal Models:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dlst):
     behavior/neurological  growth/size  nervous system  other 

    DLST for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DLST gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TCA Cycle
    		TCA Cycle1.00
    		Pyruvate metabolism and Citric Acid (TCA) cycle0.64
    		Citrate cycle (TCA cycle)0.65
    2Lysine catabolism
    		Lysine catabolism1.00
    		2-oxoglutarate decarboxylation to succinyl-CoA0.38
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4TCA cycle II (eukaryotic)
    		TCA cycle II (eukaryotic)1.00
    		Citric acid cycle (TCA cycle)0.67
    5Neuroscience
    		Neuroscience1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DLST
        Neuroscience
    Glucose / Energy Metabolism

    3 BioSystems Pathways for DLST 
        TCA Cycle
    TCA cycle II (eukaryotic)
    2-oxoglutarate decarboxylation to succinyl-CoA

    5/6        Reactome Pathways for DLST (see all 6)
        Pyruvate metabolism and Citric Acid (TCA) cycle
    Lysine catabolism
    Metabolism
    Citric acid cycle (TCA cycle)
    The citric acid (TCA) cycle and respiratory electron transport


    3         Kegg Pathways  (Kegg details for DLST):
        Citrate cycle (TCA cycle)
    Lysine degradation
    Metabolic pathways

    UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
    Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6


    DLST for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DLST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/191 Interacting proteins for DLST (P369572, 3 ENSP000003353044) via UniProtKB, MINT, STRING, and/or I2D (see all 191)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108092, 3, ENSP000003400194MINT-4054731 I2D: score=2 STRING: ENSP00000340019
    DDOSTP396562, 3MINT-4054731 I2D: score=1 
    ATP6V1B2P212812, 3, ENSP000002763904MINT-4054731 I2D: score=1 STRING: ENSP00000276390
    FLIIQ130453, ENSP000003245734I2D: score=4 STRING: ENSP00000324573
    UMPSP111723, ENSP000002326074I2D: score=3 STRING: ENSP00000232607
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS8009371
    GO:0006099tricarboxylic acid cycle TAS--
    GO:00061032-oxoglutarate metabolic process ----
    GO:0006554lysine catabolic process TAS--
    GO:0006734NADH metabolic process ----


    DLST for ontologies           About GeneDecksing



    Drugs & Compounds
    for DLST gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DLST for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLST

    6 HMDB Compounds for DLST    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-SuccinyldihydrolipoamideS-Succinyldihydrolipoamide (see all 2)----
    Dihydrolipoamidedihydrolipoamide (see all 6)3884-47-7--
    Glutaryl-CoAglutaryl-CoA (see all 2)103192-48-9--
    Lipoic acid(+)-alpha-Lipoate (see all 92)1077-28-7--
    S-Glutaryldihydrolipoamide ----
    Succinyl-CoACoenzyme A S-(hydrogen succinate) (see all 24)604-98-8--
    3 Novoseek chemical compound relationships for DLST gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrolipoamide 93.7 12 15075342 (2), 12652908 (1), 8619544 (1), 9450778 (1) (see all 10)
    alpha-ketoglutarate 89.1 18 8009371 (2), 15075342 (2), 9450778 (2), 12652908 (1) (see all 13)
    pyruvate 55.8 2 15075342 (2)

    Search CenterWatch for drugs/clinical trials and news about DLST / ODO2 

    Transcripts
    for DLST gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DLST gene (2 alternative transcripts): 
    NM_001244883.1  NM_001933.4  

    Unigene Cluster for DLST:

    Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
    Hs.525459  [show with all ESTs]
    Unigene Representative Sequence: NM_001933
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556460 ENST00000334220(uc001xqu.2 uc001xqv.2 uc001xqs.3 uc001xqt.2 uc010tuw.1)
    ENST00000555492 ENST00000557012 ENST00000554612 ENST00000556582 ENST00000238671
    ENST00000555071(uc010tuu.2) ENST00000556190 ENST00000555459 ENST00000555190
    ENST00000555089 ENST00000554806 ENST00000555988 ENST00000550473 ENST00000334212


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLST
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate DLST (see all 37):
    hsa-miR-124* hsa-let-7d hsa-miR-15a hsa-miR-938 hsa-miR-218 hsa-miR-29b-1* hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: DLST 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLST (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK289414.1 AK299505.1 AK300396.1 AK316463.1 BC000302.2 BC001922.1 BC002735.2 BX248276.1 
    BX248764.1 BX248774.1 CR456727.1 D16373.1 D17297.1 L37418.1 NR_033814.1 NR_045209.1 

    18 DOTS entries:

    DT.453765  DT.92439236  DT.75109878  DT.92439234  DT.100813975  DT.100813973  DT.100761902  DT.91718816 
    DT.92014352  DT.99958124  DT.100813977  DT.120771811  DT.75200367  DT.91924663  DT.92439235  DT.97790453 
    DT.97845678  DT.100813969 

    24/238 AceView cDNA sequences (see all 238):

    CR600036 CD724051 AI805200 BE671035 BF219729 NM_001933 CK725012 BM928746 
    BX395796 AI768855 AL538322 AL554351 BM929953 AU133381 BU607907 AA291301 
    AU131128 BF056135 CB529453 BX396472 BQ549617 BM468606 BI828414 AI738526 

    GeneLoc Exon Structure


    Expression
    for DLST gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTTGTATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DLST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLST

    SOURCE GeneReport for Unigene cluster: Hs.525459
        SABiosciences Expression via Pathway-Focused PCR Arrays including DLST: 
              Amino Acid Metabolism II in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLST

    Orthologs
    for DLST gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DLST gene from 11/43 species (see all 43)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dlst1 , 5 dihydrolipoamide S-succinyltransferase (E2 component more1, 5 89.31(n)1
    92.7(a)1    		   12 (39.55 cM)5
    789201  NM_030225.41  NP_084501.11 
     851108335 
    chicken
    (Gallus gallus)    		 Aves DLST1 dihydrolipoamide S-succinyltransferase (E2 component more 76.67(n)
    81.39(a)    		   423357  NM_001012901.1  NP_001012919.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DLST6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 1(22732893-22752659)
    African clawed frog
    (Xenopus laevis)    		 Amphibia dlst-prov2 dihydrolipoamide S-succinyltransferase (E2 component more 80.37(n)    BC045016.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.37862 Danio rerio mRNA similar to dihydrolipoamide S-succinyltransferase more 77.84(n)    BC045500.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG52141 , 3 dihydrolipoamide S-succinyltransferase3
    CG52141    		 72(a)3
    61.65(n)1
    64.91(a)1    		   86E13
    413601  NM_141807.11  NP_650064.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea W02F12.53
    dlst-11    		 dihydrolipoamide succinyltransferase3
    Protein DLST-11    		 67(a)3
    58.75(n)1
    61.88(a)1    		   V(6709896-6711691)3
    1790631  NM_072299.41  NP_504700.21 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes KGD2(YDR148C)4
    KGD21    		 Dihydrolipoyl transsuccinylase, component of the mitochondrial more4
    Kgd2p1    		 50.25(n)1
    48.51(a)1    		   4(755066-753675)4
    8517261, 4  NP_010432.31  NP_010432.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G550701 dihydrolipoyllysine-residue succinyltransferase component more 55.75(n)
    52(a)    		   835598  NM_124889.4  NP_200318.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.87482 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.44(n)    AK121002.1 


    ENSEMBL Gene Tree for DLST (if available)
    TreeFam Gene Tree for DLST (if available) 

    Paralogs
    for DLST gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLST gene
    1 SIMAP similar gene for DLST using alignment to 12 protein entries:     ODO2_HUMAN (see all proteins):
    DLSTP

    DLST for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DLST
    PGOHUM00000244072


    Genomic Variants
    for DLST gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/459 NCBI SNPs in DLST are shown (see all 459)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1137221171,2
    		--55515242(+) AAAGCG/CAGAGC 4 -- us2k12Minor allele frequency- C:0.02CSA EA 122
    rs1132607591,2
    		--55515248(+) AGAGCG/CGAGGC 4 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs733057811,2
    		C,--55516961(+) CCCCAC/TCCTCC 4 -- int11Minor allele frequency- T:0.50WA 2
    rs80065601,2
    		C,F,H,--55517103(+) TCCCGT/CTGGGA 4 -- int120Minor allele frequency- C:0.19NS EA NA WA CSA 2227
    rs80071141,2
    		C,F,A,H,--55517434(+) CAGTTT/CGGTTC 4 -- int128Minor allele frequency- C:0.17NS EA NA WA CSA 2832
    rs116257861,2
    		H--55517448(+) GAGTAG/TTGAGA 4 -- int10--------
    rs771818531,2
    		C,F,--55517478(+) GAGCTA/GTCGCT 4 -- int11Minor allele frequency- G:0.02WA 118
    rs118488071,2
    		C,H,--55517659(+) GAGAAG/AGAAAC 4 -- int1 trp32Minor allele frequency- A:0.06NA WA 120
    rs101425741,2
    		C,--55517725(+) CCGGGC/TGCGGT 4 -- int12Minor allele frequency- T:0.06WA NA 122
    rs101428221,2
    		C,--55517771(+) gaggcG/Aggcgg 4 -- int12Minor allele frequency- A:0.33NA CSA 3

    HapMap Linkage Disequilibrium report for DLST (75348594 - 75370450 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DLST
         1 CNV: 4839

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLST
    DNA2.0 Custom Variant and Variant Library Synthesis for DLST

    Disorders / Diseases
    for DLST gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DLST for disorders           About GeneDecksing

    OMIM gene information: 126063    OMIM disorders: --

    17 diseases for DLST:    About MalaCards
    alpha-ketoglutarate dehydrogenase deficiency    maple syrup urine disease    wernicke-korsakoff syndrome    cat-scratch disease
    primary biliary cirrhosis    friedreich ataxia    spinocerebellar ataxia    parkinson's disease
    alzheimer's disease    ataxia    neurodegeneration    prostate cancer
    pneumonia    prostatitis    tuberculosis    malaria
    mycobacterium tuberculosis

    2 Novoseek disease relationships for DLST gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 59.6 10 11825528 (2), 7974008 (1), 9894876 (1), 8584231 (1) (see all 8)
    parkinson disease 10.1 3 9450778 (2), 10676873 (1)

    Genetic Association Database (GAD): DLST
    Human Genome Epidemiology (HuGE) Navigator: DLST (6 documents)

    Export disorders for DLST gene to outside databases

    Publications
    for DLST gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLST gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with DLST)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. (PubMed id 8009371)1, 3, 9 Ali G.... Blass J.P. (1994)
    2. No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (PubMed id 11445257)1, 4, 9 Matsushita S....Higuchi S. (2001)
    3. [Association between DLST gene polymorphism and Alzheimer's disease] (PubMed id 11825528)1, 4, 9 Ma Q....Yang J. (2001)
    4. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PubMed id 11436125)1, 4, 9 Prince J.A....Brookes A.J. (2001)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex. (PubMed id 8076640)1, 2 Nakano K....Matuda S. (1994)
    7. Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3. (PubMed id 8268217)1, 2 Nakano K.... Miyata T. (1993)
    8. Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. (PubMed id 9894876)1, 9 Sheu K.F....Blass J.P. (1999)
    9. Mutation analysis of the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in patients with early-onset Alzheimer disease. (PubMed id 8584231)1, 9 Cruts M....Adolfsson R. (1995)
    10. Substantial linkage disequilibrium across the dihydrolipoyl succinyltransferase gene region without Alzheimer's disease association. (PubMed id 15038610)1, 9 Brown A.M....Blass J.P. (2004)

    External Searches for DLST gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DLST gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1743 HGNC: 2911 AceView: DLST Ensembl:ENSG00000119689 euGenes: HUgn1743
    ECgene: DLST Kegg: 1743 H-InvDB: DLST

    Other Databases showing DLST gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DLST gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLST Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DLST gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DLST gene:
    Search GeneIP for patents involving DLST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DLST gene

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    About This Section

     
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