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DLST Gene

protein-coding   GIFtS: 67
GCID: GC14P075348

Dihydrolipoamide S-Succinyltransferase (E2 Component Of...


(Previous symbol: DLTS)
  See DLST-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dihydrolipoamide S-Succinyltransferase (E2 Component Of 2-Oxo-Glutarate
Complex)1 2
     Dihydrolipoyllysine-Residue Succinyltransferase Component Of
2-Oxoglutarate Dehydrogenase Complex, Mitochondrial2
DLTS1 2 3     2-Oxoglutarate Dehydrogenase Complex Component E23
E2K2 3     Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate
Dehydrogenase Complex3
OGDC-E22 3     EC 2.3.18
EC 2.3.1.613 8     

External Ids:    HGNC: 29111   Entrez Gene: 17432   Ensembl: ENSG000001196897   OMIM: 1260635   UniProtKB: P369573   

Export aliases for DLST gene to outside databases

Previous GC identifers: GC14P072875 GC14P069166 GC14P073338 GC14P074418 GC14P055516


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLST Gene:
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one
of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall
conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found
for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for DLST Gene:
DLST (dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)) is a protein-coding gene. Diseases associated with DLST include alpha-ketoglutarate dehydrogenase deficiency, and wernicke-korsakoff syndrome. GO annotations related to this gene include dihydrolipoyllysine-residue succinyltransferase activity. An important paralog of this gene is DBT.

UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to
succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1),
dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Wiki entry for DLST Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLST gene promoter:
         Sp1   AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   C/EBPalpha   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLST promoter sequence
   Search Chromatin IP Primers for DLST

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q23.1

DLST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLST gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075348:  view genomic region     (about GC identifiers)

Start:
75,348,594 bp from pter      End:
75,370,450 bp from pter
Size:
21,857 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957 (See protein sequence)
Recommended Name: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase
complex, mitochondrial precursor  
Size: 453 amino acids; 48755 Da
Cofactor: Binds 1 lipoyl cofactor covalently
Subunit: Forms a 24-polypeptide structural core with octahedral symmetry
Secondary accessions: Q7LDY7 Q9BQ32

Explore the universe of human proteins at neXtProt for DLST: NX_P36957

Explore proteomics data for DLST at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys203, Lys217
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DLST (P36957) (see all 17)
     VPVIRNV  GTFTISN  SVAVATP  YDHRLIDG 


    See DLST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231812.1  NP_001924.2  

    ENSEMBL proteins: 
     ENSP00000451210   ENSP00000335304   ENSP00000452417   ENSP00000451670   ENSP00000238671  
     ENSP00000452422   ENSP00000451957   ENSP00000451425   ENSP00000335465  
    Reactome Protein details: P36957

    DLST Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DLST
    OriGene Protein Over-expression Lysate for DLST
    OriGene MassSpec for DLST
    OriGene Custom Protein Services for DLST
    GenScript Custom Purified and Recombinant Proteins Services for DLST
    Novus Biologicals DLST Proteins
    Novus Biologicals DLST Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DLST
    Cloud-Clone Corp. Proteins for DLST

     
    Search eBioscience for Proteins for DLST 

     
    antibodies-online proteins for DLST (8 products) 

     
    antibodies-online peptides for DLST

    DLST Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DLST 
    OriGene Antibodies for DLST
    OriGene Custom Antibody Services for DLST
    Novus Biologicals DLST Antibodies
    Abcam antibodies for DLST
    Cloud-Clone Corp. Antibodies for DLST
    ThermoFisher Antibody for DLST
    antibodies-online antibodies for DLST (28 products) 

    DLST Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DLST
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DLST
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DLST
    Cloud-Clone Corp. CLIAs for DLST
    Search eBioscience for ELISAs for DLST 
    antibodies-online kits for DLST (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR000089 Biotin_lipoyl
     IPR003016 2-oxoA_DH_lipoyl-BS
     IPR001078 2-oxoacid_DH_actylTfrase
     IPR023213 CAT-like_dom
     IPR006255 SucB

    Graphical View of Domain Structure for InterPro Entry P36957

    ProtoNet protein and cluster: P36957

    3 Blocks protein domains:
    IPB000089 Biotin/lipoyl attachment
    IPB001078 Catalytic domain of components of various dehydrogenase complexes
    IPB003016 2-oxo acid dehydrogenase


    UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
    Similarity: Belongs to the 2-oxoacid dehydrogenase family
    Similarity: Contains 1 lipoyl-binding domain


    Find genes that share domains with DLST           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ODO2_HUMAN, P36957
    Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to
    succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1),
    dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
    Catalytic activity: Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme
    N(6)-(S-succinyldihydrolipoyl)lysine

         Genatlas biochemistry entry for DLST:
    dihydrolipoamide S-succinyltransferase

         Enzyme Numbers (IUBMB): EC 2.3.1.611 2 EC 2.3.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004149dihydrolipoyllysine-residue succinyltransferase activity IEA--
    GO:0016740transferase activity ----
    GO:0016746transferase activity, transferring acyl groups ----
         
    Find genes that share ontologies with DLST           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dlst):
     behavior/neurological  growth/size/body  nervous system  other 

    Find genes that share phenotypes with DLST           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DLST

    miRNA
    Products:
        
    miRTarBase miRNAs that target DLST:
    hsa-mir-1301-3p (MIRT036029), hsa-mir-106a-5p (MIRT048341), hsa-mir-92b-3p (MIRT040701), hsa-mir-125a-5p (MIRT045733), hsa-mir-615-3p (MIRT039832), hsa-mir-324-3p (MIRT042860), hsa-mir-92b-5p (MIRT037800), hsa-mir-503-5p (MIRT041111)

    Block miRNA regulation of human, mouse, rat DLST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLST (see all 37):
    hsa-miR-124* hsa-let-7d hsa-miR-15a hsa-miR-938 hsa-miR-218 hsa-miR-29b-1* hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDLST 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLST
    Predesigned siRNA for gene silencing in human, mouse, rat DLST

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DLST

    Clone
    Products:
         
    OriGene clones in human, mouse for DLST (see all 6)
    OriGene ORF clones in mouse, rat for DLST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLST (NM_001933)
    Sino Biological Human cDNA Clone for DLST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLST

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DLST
    Browse ESI BIO Cell Lines and PureStem Progenitors for DLST 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLST


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ODO2_HUMAN, P36957: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix TAS--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with DLST           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DLST About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Citric acid cycle (TCA cycle)0.55
    conversion of glucose to acetyl CoA and entry into the TCA cycle0.43
    Citrate cycle (TCA cycle)0.55
    TCA Cycle0.00
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    TCA cycle0.00
    2Metabolism of amino acids and derivatives
    Lysine catabolism0.00
    2-oxoglutarate decarboxylation to succinyl-CoA0.00
    Metabolism of amino acids and derivatives
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    5Carbon metabolism
    Carbon metabolism0.38


    Find genes that share SuperPaths with DLST           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DLST
        Neuroscience
    Glucose / Energy Metabolism

    4 BioSystems Pathways for DLST
        TCA Cycle
    TCA cycle
    2-oxoglutarate decarboxylation to succinyl-CoA
    conversion of glucose to acetyl CoA and entry into the TCA cycle


    2 Reactome Pathways for DLST
        Lysine catabolism
    Citric acid cycle (TCA cycle)


    4 Kegg Pathways  (Kegg details for DLST):
        Citrate cycle (TCA cycle)
    Lysine degradation
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
    Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step
    6/6

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLST: 

              Amino Acid Metabolism II in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DLST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DLST (P369572, 3 ENSP000003353044) via UniProtKB, MINT, STRING, and/or I2D (see all 214)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108092, 3, ENSP000003400194MINT-4054731 I2D: score=2 STRING: ENSP00000340019
    DDOSTP396562, 3MINT-4054731 I2D: score=1 
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    ENSG00000226225P622693I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS8009371
    GO:0006099tricarboxylic acid cycle TAS--
    GO:0006554lysine catabolic process TAS--
    GO:0008152metabolic process ----
    GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopine IEA--

    Find genes that share ontologies with DLST           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLST (ODO2)

    6 HMDB Compounds for DLST    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-SuccinyldihydrolipoamideS-Succinyldihydrolipoamide (see all 2)----
    Dihydrolipoamidedihydrolipoamide (see all 6)3884-47-7--
    Glutaryl-CoAglutaryl-CoA (see all 2)103192-48-9--
    Lipoic acid(+)-alpha-Lipoate (see all 92)1077-28-7--
    S-Glutaryldihydrolipoamide ----
    Succinyl-CoACoenzyme A S-(hydrogen succinate) (see all 24)604-98-8--

    3 Novoseek inferred chemical compound relationships for DLST gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrolipoamide 93.7 12 15075342 (2), 12652908 (1), 8619544 (1), 9450778 (1) (see all 10)
    alpha-ketoglutarate 89.1 18 8009371 (2), 15075342 (2), 9450778 (2), 12652908 (1) (see all 13)
    pyruvate 55.8 2 15075342 (2)



    Find genes that share compounds with DLST           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DLST gene (2 alternative transcripts): 
    NM_001244883.1  NM_001933.4  

    Unigene Cluster for DLST:

    Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
    Hs.525459  [show with all ESTs]
    Unigene Representative Sequence: NM_001933
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556460 ENST00000334220(uc001xqu.2 uc001xqv.2 uc001xqs.3 uc001xqt.2 uc010tuw.1)
    ENST00000555492 ENST00000557012 ENST00000554612 ENST00000556582 ENST00000238671
    ENST00000555071(uc010tuu.2) ENST00000556190 ENST00000555459 ENST00000555190
    ENST00000555089 ENST00000554806 ENST00000555988 ENST00000550473 ENST00000334212

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DLST using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLST (see all 37):
    hsa-miR-124* hsa-let-7d hsa-miR-15a hsa-miR-938 hsa-miR-218 hsa-miR-29b-1* hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDLST 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DLST
    Predesigned siRNA for gene silencing in human, mouse, rat DLST
    Clone
    Products:
         
    OriGene clones in human, mouse for DLST (see all 6)
    OriGene ORF clones in mouse, rat for DLST
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLST (NM_001933)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLST
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DLST
    OriGene qSTAR qPCR primer pairs in human, mouse for DLST
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLST
      QuantiTect SYBR Green Assays in human, mouse, rat DLST
      QuantiFast Probe-based Assays in human, mouse, rat DLST

    Additional mRNA sequence: 

    AK289414.1 AK299505.1 AK300396.1 AK316463.1 BC000302.2 BC001922.1 BC002735.2 BX248276.1 
    BX248764.1 BX248774.1 CR456727.1 D16373.1 D17297.1 L37418.1 NR_033814.1 NR_045209.1 

    18 DOTS entries:

    DT.453765  DT.92439236  DT.75109878  DT.92439234  DT.100813975  DT.100813973  DT.100761902  DT.91718816 
    DT.92014352  DT.99958124  DT.100813977  DT.120771811  DT.75200367  DT.91924663  DT.92439235  DT.97790453 
    DT.97845678  DT.100813969 

    Selected AceView cDNA sequences (see all 238):

    CR600036 AL538322 BX379943 AI768855 BM662413 BM929953 BU623022 CD367759 
    BI828414 BX248764 BP341159 AU133426 CB529453 CD724051 BE671035 BF219729 
    BX396472 AI805200 BG057758 AA291301 BU607907 AU131128 NM_001933 BM971960 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTGTATC
    DLST Expression
    About this image


    DLST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
    DLST Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLST Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525459
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLST: 
              Amino Acid Metabolism II in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DLST
    OriGene qSTAR qPCR primer pairs in human, mouse for DLST
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLST
    QuantiTect SYBR Green Assays in human, mouse, rat DLST
    QuantiFast Probe-based Assays in human, mouse, rat DLST
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DLST gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlst1 , 5 dihydrolipoamide S-succinyltransferase (E2 component more1, 5 88.52(n)1
    91.39(a)1
      12 (39.55 cM)5
    789201  NM_030225.41  NP_084501.11 
     851108335 
    chicken
    (Gallus gallus)
    Aves DLST1 dihydrolipoamide S-succinyltransferase (E2 component more 75.85(n)
    79.65(a)
      423357  NM_001012901.1  NP_001012919.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLST6
    dihydrolipoamide S-succinyltransferase (E2 compone...
    72(a)
    1 ↔ 1
    1(22732893-22753012)
    African clawed frog
    (Xenopus laevis)
    Amphibia dlst-prov2 dihydrolipoamide S-succinyltransferase (E2 component more 80.37(n)    BC045016.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.37862 Danio rerio mRNA similar to dihydrolipoamide S-succinyltransferase more 77.84(n)    BC045500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52143 dihydrolipoamide S-succinyltransferase 72(a)   86E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea W02F12.53
    dlst-11
    dihydrolipoamide succinyltransferase3
    dlst-11
    67(a)3
    64.1(n)1
    70.94(a)1
      V(6709896-6711691)3
    1790631  NM_072299.51  NP_504700.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KGD2(YDR148C)4
    KGD21
    Dihydrolipoyl transsuccinylase, component of the mitochondrial more4
    KGD21
    57.3(n)1
    59.92(a)1
      4(755066-753675)4
    8517261, 4  NP_010432.31  NP_010432.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G550701 AT5G55070 54.69(n)
    49.5(a)
      835598  NM_124889.4  NP_200318.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87482 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.44(n)    AK121002.1 


    ENSEMBL Gene Tree for DLST (if available)
    TreeFam Gene Tree for DLST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLST gene
    DBT2  DLAT2  
    1 SIMAP similar gene for DLST using alignment to 12 protein entries:     ODO2_HUMAN (see all proteins):
    DLSTP

    Find genes that share paralogs with DLST           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DLST
    PGOHUM00000244072


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for DLST (see all 593)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143259821,2
    F--56338441(+) TCAGAG/AGCCTG 4 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1845065351,2
    --56338458(+) AGGTGA/CCTGGC 4 -- us2k10--------
    rs284263741,2
    C,F--56338463(+) CCTGGT/CCAAGT 4 -- us2k110Minor allele frequency- C:0.49NA WA CSA EA 372
    rs1902405421,2
    --56338638(+) GAGACA/GAAGTC 4 -- us2k10--------
    rs37597411,2
    C,F--56338764(-) ggtagC/Tgaatg 4 -- us2k18Minor allele frequency- T:0.36NA WA CSA 14
    rs1824723471,2
    --56338774(+) CACACA/CCAGCT 4 -- us2k10--------
    rs1863796951,2
    C--56338806(+) GATGGC/GGTTTC 4 -- us2k10--------
    rs1137221171,2
    C,F--56338963(+) AAAGCG/CAGAGC 4 -- us2k12Minor allele frequency- C:0.02CSA EA 122
    rs1132607591,2
    F--56338969(+) AGAGCG/CGAGGC 4 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1477011741,2
    --56338983(+) GAACTA/GCTTAG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for DLST (75348594 - 75370450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DLST:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832832CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLST
    DNA2.0 Custom Variant and Variant Library Synthesis for DLST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 126063    OMIM disorders: --

    2 diseases for DLST:    
    About MalaCards
    alpha-ketoglutarate dehydrogenase deficiency    wernicke-korsakoff syndrome


    Find genes that share disorders with DLST           About GenesLikeMe

    2 Novoseek inferred disease relationships for DLST gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 59.6 10 11825528 (2), 7974008 (1), 9894876 (1), 8584231 (1) (see all 8)
    parkinson disease 10.1 3 9450778 (2), 10676873 (1)

    Genetic Association Database (GAD): DLST
    Human Genome Epidemiology (HuGE) Navigator: DLST (6 documents)

    Export disorders for DLST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLST gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with DLST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. (PubMed id 8009371)1, 3, 9 Ali G.... Blass J.P. (Somat. Cell Mol. Genet. 1994)
    2. No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (PubMed id 11445257)1, 4, 9 Matsushita S....Higuchi S. (Neurobiol. Aging 2001)
    3. [Association between DLST gene polymorphism and Alzheimer's disease]. (PubMed id 11825528)1, 4, 9 Ma Q....Yang J. (Zhonghua Yi Xue Za Zhi 2001)
    4. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PubMed id 11436125)1, 4, 9 Prince J.A....Brookes A.J. (Eur. J. Hum. Genet. 2001)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex. (PubMed id 8076640)1, 2 Nakano K....Matuda S. (Eur. J. Biochem. 1994)
    9. Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3. (PubMed id 8268217)1, 2 Nakano K.... Miyata T. (Biochim. Biophys. Acta 1993)
    10. Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. (PubMed id 9894876)1, 9 Sheu K.F....Blass J.P. (Ann. Neurol. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1743 HGNC: 2911 AceView: DLST Ensembl:ENSG00000119689 euGenes: HUgn1743
    ECgene: DLST Kegg: 1743 H-InvDB: DLST

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DLST Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DLST gene:
    Search GeneIP for patents involving DLST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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