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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLST Gene

protein-coding   GIFtS: 67
GCID: GC14P075348

Dihydrolipoamide S-Succinyltransferase (E2 Component Of...


(Previous symbol: DLTS)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dihydrolipoamide S-Succinyltransferase (E2 Component Of 2-Oxo-Glutarate
Complex)1 2
     Dihydrolipoyllysine-Residue Succinyltransferase Component Of
2-Oxoglutarate Dehydrogenase Complex, Mitochondrial2
DLTS1 2 3     2-Oxoglutarate Dehydrogenase Complex Component E23
E2K2 3     Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate
Dehydrogenase Complex3
OGDC-E22 3     EC 2.3.18
EC 2.3.1.613 8     

External Ids:    HGNC: 29111   Entrez Gene: 17432   Ensembl: ENSG000001196897   OMIM: 1260635   UniProtKB: P369573   
ORGUL members:         
NONCODE14:n409414      

Export aliases for DLST gene to outside databases

Previous GC identifers: GC14P072875 GC14P069166 GC14P073338 GC14P074418 GC14P055516


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLST Gene:
This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one
of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall
conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found
for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for DLST Gene: 
DLST (dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with DLST include alpha-ketoglutarate dehydrogenase deficiency, and wernicke-korsakoff syndrome, and among its related super-pathways are Citric acid cycle (TCA cycle) and Metabolic pathways. GO annotations related to this gene include dihydrolipoyllysine-residue succinyltransferase activity.

UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to
succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1),
dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Wiki entry for DLST Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLST gene promoter:
         Sp1   AP-2alpha isoform 3   Nkx2-5   AP-2alpha isoform 2   C/EBPalpha   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLST promoter sequence
   Search SABiosciences Chromatin IP Primers for DLST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q23.1

DLST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLST gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075348:  view genomic region     (about GC identifiers)

Start:
75,348,594 bp from pter      End:
75,370,450 bp from pter
Size:
21,857 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957 (See protein sequence)
Recommended Name: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase
complex, mitochondrial precursor  
Size: 453 amino acids; 48755 Da
Cofactor: Binds 1 lipoyl cofactor covalently
Subunit: Forms a 24-polypeptide structural core with octahedral symmetry
Subcellular location: Mitochondrion
Secondary accessions: Q7LDY7 Q9BQ32

Explore the universe of human proteins at neXtProt for DLST: NX_P36957

Explore proteomics data for DLST at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36957

  • 4/17 DME Specific Peptides for DLST (P36957) (see all 17)
     VPVIRNV  GTFTISN  SVAVATP  YDHRLIDG 

    DLST Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DLST Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231812.1  NP_001924.2  

    ENSEMBL proteins: 
     ENSP00000451210   ENSP00000335304   ENSP00000452417   ENSP00000451670   ENSP00000238671  
     ENSP00000452422   ENSP00000451957   ENSP00000451425   ENSP00000335465  
    Reactome Protein details: P36957
    Human Recombinant Protein Products for DLST: 
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    Novus Biologicals DLST Proteins
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    Cloud-Clone Corp. Proteins for DLST 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    DLST for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000089 Biotin_lipoyl
     IPR003016 2-oxoA_DH_lipoyl-BS
     IPR001078 2-oxoacid_DH_actylTfrase
     IPR023213 CAT-like_dom
     IPR006255 SucB

    Graphical View of Domain Structure for InterPro Entry P36957

    ProtoNet protein and cluster: P36957

    3 Blocks protein domains:
    IPB000089 Biotin/lipoyl attachment
    IPB001078 Catalytic domain of components of various dehydrogenase complexes
    IPB003016 2-oxo acid dehydrogenase


    UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
    Similarity: Belongs to the 2-oxoacid dehydrogenase family
    Similarity: Contains 1 lipoyl-binding domain


    DLST for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ODO2_HUMAN, P36957
    Function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to
    succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1),
    dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
    Catalytic activity: Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme
    N(6)-(S-succinyldihydrolipoyl)lysine

         Genatlas biochemistry entry for DLST:
    dihydrolipoamide S-succinyltransferase

         Enzyme Numbers (IUBMB): EC 2.3.1.611 2 EC 2.3.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004149dihydrolipoyllysine-residue succinyltransferase activity IEA--
    GO:0016740transferase activity ----
    GO:0016746transferase activity, transferring acyl groups ----
         
    DLST for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dlst):
     behavior/neurological  growth/size  nervous system  other 

    DLST for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DLST 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DLST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLST 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLST 

    miRNA
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    hsa-miR-124* hsa-let-7d hsa-miR-15a hsa-miR-938 hsa-miR-218 hsa-miR-29b-1* hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDLST 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DLST About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Citric acid cycle (TCA cycle)0.89
    TCA cycle0.84
    TCA Cycle0.89
    Citrate cycle (TCA cycle)0.58
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Lysine catabolism
    2-oxoglutarate decarboxylation to succinyl-CoA0.38
    Lysine catabolism0.38
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72
    5Pyruvate metabolism
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DLST
        Neuroscience
    Glucose / Energy Metabolism

    4 BioSystems Pathways for DLST
        TCA Cycle
    TCA cycle
    2-oxoglutarate decarboxylation to succinyl-CoA
    Conversion of glucose to acetyl CoA and entry into the TCA cycle


    5/6        Reactome Pathways for DLST (see all 6)
        Pyruvate metabolism and Citric Acid (TCA) cycle
    Lysine catabolism
    Metabolism
    Citric acid cycle (TCA cycle)
    The citric acid (TCA) cycle and respiratory electron transport


    4         Kegg Pathways  (Kegg details for DLST):
        Citrate cycle (TCA cycle)
    Lysine degradation
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: ODO2_HUMAN, P36957
    Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step
    6/6


    DLST for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DLST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/195 Interacting proteins for DLST (P369572, 3 ENSP000003353044) via UniProtKB, MINT, STRING, and/or I2D (see all 195)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108092, 3, ENSP000003400194MINT-4054731 I2D: score=2 STRING: ENSP00000340019
    DDOSTP396562, 3MINT-4054731 I2D: score=1 
    ENSG00000096150P622693I2D: score=1 
    ENSG00000223367P622693I2D: score=1 
    ENSG00000226225P622693I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS8009371
    GO:0006099tricarboxylic acid cycle TAS--
    GO:0006554lysine catabolic process TAS--
    GO:0008152metabolic process ----
    GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopine IEA--

    DLST for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DLST for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLST (ODO2)

    6 HMDB Compounds for DLST    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-SuccinyldihydrolipoamideS-Succinyldihydrolipoamide (see all 2)----
    Dihydrolipoamidedihydrolipoamide (see all 6)3884-47-7--
    Glutaryl-CoAglutaryl-CoA (see all 2)103192-48-9--
    Lipoic acid(+)-alpha-Lipoate (see all 92)1077-28-7--
    S-Glutaryldihydrolipoamide ----
    Succinyl-CoACoenzyme A S-(hydrogen succinate) (see all 24)604-98-8--

    3 Novoseek inferred chemical compound relationships for DLST gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrolipoamide 93.7 12 15075342 (2), 12652908 (1), 8619544 (1), 9450778 (1) (see all 10)
    alpha-ketoglutarate 89.1 18 8009371 (2), 15075342 (2), 9450778 (2), 12652908 (1) (see all 13)
    pyruvate 55.8 2 15075342 (2)

    Search CenterWatch for drugs/clinical trials and news about DLST / ODO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DLST gene (2 alternative transcripts): 
    NM_001244883.1  NM_001933.4  

    Unigene Cluster for DLST:

    Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
    Hs.525459  [show with all ESTs]
    Unigene Representative Sequence: NM_001933
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556460 ENST00000334220(uc001xqu.2 uc001xqv.2 uc001xqs.3 uc001xqt.2 uc010tuw.1)
    ENST00000555492 ENST00000557012 ENST00000554612 ENST00000556582 ENST00000238671
    ENST00000555071(uc010tuu.2) ENST00000556190 ENST00000555459 ENST00000555190
    ENST00000555089 ENST00000554806 ENST00000555988 ENST00000550473 ENST00000334212


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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate DLST (see all 37):
    hsa-miR-124* hsa-let-7d hsa-miR-15a hsa-miR-938 hsa-miR-218 hsa-miR-29b-1* hsa-let-7g hsa-miR-424
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    Additional mRNA sequence: 

    AK289414.1 AK299505.1 AK300396.1 AK316463.1 BC000302.2 BC001922.1 BC002735.2 BX248276.1 
    BX248764.1 BX248774.1 CR456727.1 D16373.1 D17297.1 L37418.1 NR_033814.1 NR_045209.1 

    18 DOTS entries:

    DT.453765  DT.92439236  DT.75109878  DT.92439234  DT.100813975  DT.100813973  DT.100761902  DT.91718816 
    DT.92014352  DT.99958124  DT.100813977  DT.120771811  DT.75200367  DT.91924663  DT.92439235  DT.97790453 
    DT.97845678  DT.100813969 

    24/238 AceView cDNA sequences (see all 238):

    AA291301 BX115643 CK725012 BG057758 CR600036 BE671035 BX396472 BU623022 
    BX379943 AI685838 AU133381 BF056135 BM928746 AL538322 CD367759 CB529453 
    BP341159 AI335698 AL530774 BM929953 AL554351 NM_001933 BX248276 BQ549617 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLST expression in normal human tissues (normalized intensities)      DLST embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTGTATC
    DLST Expression
    About this image


    DLST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See DLST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLST

    SOURCE GeneReport for Unigene cluster: Hs.525459
        SABiosciences Expression via Pathway-Focused PCR Arrays including DLST: 
              Amino Acid Metabolism II in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Glucose Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DLST gene from 10/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlst1 , 5 dihydrolipoamide S-succinyltransferase (E2 component more1, 5 89.31(n)1
    92.7(a)1
      12 (39.55 cM)5
    789201  NM_030225.41  NP_084501.11 
     851108335 
    chicken
    (Gallus gallus)
    Aves DLST1 dihydrolipoamide S-succinyltransferase (E2 component more 76.67(n)
    81.39(a)
      423357  NM_001012901.1  NP_001012919.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLST6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    1(22732893-22753012)
    African clawed frog
    (Xenopus laevis)
    Amphibia dlst-prov2 dihydrolipoamide S-succinyltransferase (E2 component more 80.37(n)    BC045016.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.37862 Danio rerio mRNA similar to dihydrolipoamide S-succinyltransferase more 77.84(n)    BC045500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52141 , 3 dihydrolipoamide S-succinyltransferase3
    CG52141
    72(a)3
    61.65(n)1
    64.91(a)1
      86E13
    413601  NM_141807.11  NP_650064.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W02F12.53
    dlst-11
    dihydrolipoamide succinyltransferase3
    Protein DLST-11
    67(a)3
    58.75(n)1
    61.88(a)1
      V(6709896-6711691)3
    1790631  NM_072299.41  NP_504700.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KGD2(YDR148C)4
    KGD21
    Dihydrolipoyl transsuccinylase, component of the mitochondrial more4
    Kgd2p1
    50.25(n)1
    48.51(a)1
      4(755066-753675)4
    8517261, 4  NP_010432.31  NP_010432.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G550701 dihydrolipoyllysine-residue succinyltransferase component more 55.75(n)
    52(a)
      835598  NM_124889.4  NP_200318.1 
    rice
    (Oryza sativa)
    Liliopsida Os.87482 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.44(n)    AK121002.1 


    ENSEMBL Gene Tree for DLST (if available)
    TreeFam Gene Tree for DLST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLST gene
    1 SIMAP similar gene for DLST using alignment to 12 protein entries:     ODO2_HUMAN (see all proteins):
    DLSTP

    DLST for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DLST
    PGOHUM00000244072


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/593 SNPs in DLST are shown (see all 593)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0049774
    ----see VAR_0049772 P T mis40--------
    VAR_0049764
    ----see VAR_0049762 P A mis40--------
    rs1143259821,2
    F--56338441(+) TCAGAG/AGCCTG 4 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1845065351,2
    --56338458(+) AGGTGA/CCTGGC 4 -- us2k10--------
    rs284263741,2
    C,F--56338463(+) CCTGGT/CCAAGT 4 -- us2k110Minor allele frequency- C:0.49NA WA CSA EA 372
    rs1902405421,2
    --56338638(+) GAGACA/GAAGTC 4 -- us2k10--------
    rs37597411,2
    C,F--56338764(-) ggtagC/Tgaatg 4 -- us2k18Minor allele frequency- T:0.36NA WA CSA 14
    rs1824723471,2
    --56338774(+) CACACA/CCAGCT 4 -- us2k10--------
    rs1863796951,2
    C--56338806(+) GATGGC/GGTTTC 4 -- us2k10--------
    rs1137221171,2
    C,F--56338963(+) AAAGCG/CAGAGC 4 -- us2k12Minor allele frequency- C:0.02CSA EA 122

    HapMap Linkage Disequilibrium report for DLST (75348594 - 75370450 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DLST:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832832CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DLST
    DNA2.0 Custom Variant and Variant Library Synthesis for DLST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 126063    OMIM disorders: --

    13 diseases for DLST:    About MalaCards
    alpha-ketoglutarate dehydrogenase deficiency    wernicke-korsakoff syndrome    cat-scratch disease    maple syrup urine disease
    friedreich ataxia    primary biliary cirrhosis    spinocerebellar ataxia    parkinson's disease
    ataxia    alzheimer's disease    tuberculosis    prostate cancer
    prostatitis


    DLST for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for DLST gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 59.6 10 11825528 (2), 7974008 (1), 9894876 (1), 8584231 (1) (see all 8)
    parkinson disease 10.1 3 9450778 (2), 10676873 (1)

    Genetic Association Database (GAD): DLST
    Human Genome Epidemiology (HuGE) Navigator: DLST (6 documents)

    Export disorders for DLST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLST gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with DLST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex. (PubMed id 8009371)1, 3, 9 Ali G.... Blass J.P. (1994)
    2. No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. (PubMed id 11445257)1, 4, 9 Matsushita S....Higuchi S. (2001)
    3. [Association between DLST gene polymorphism and Alzheimer's disease] (PubMed id 11825528)1, 4, 9 Ma Q....Yang J. (2001)
    4. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PubMed id 11436125)1, 4, 9 Prince J.A....Brookes A.J. (2001)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex. (PubMed id 8076640)1, 2 Nakano K....Matuda S. (1994)
    9. Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3. (PubMed id 8268217)1, 2 Nakano K.... Miyata T. (1993)
    10. Modulation by DLST of the genetic risk of Alzheimer's disease in a very elderly population. (PubMed id 9894876)1, 9 Sheu K.F....Blass J.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1743 HGNC: 2911 AceView: DLST Ensembl:ENSG00000119689 euGenes: HUgn1743
    ECgene: DLST Kegg: 1743 H-InvDB: DLST

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLST Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DLST gene:
    Search GeneIP for patents involving DLST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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