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Aliases for DLL4 Gene

Aliases for DLL4 Gene

  • Delta-Like 4 (Drosophila) 2 3 5
  • Drosophila Delta Homolog 4 3 4
  • Delta4 3 4
  • Delta-Like 4 Homolog (Drosophila) 2
  • Delta-Like 4 Homolog 3
  • Delta-Like 4 Protein 3
  • Notch Ligand Delta-2 3
  • Notch Ligand DLL4 3
  • Delta Ligand 4 3
  • Delta 4 3
  • Hdelta2 3
  • AOS6 3

External Ids for DLL4 Gene

Previous GeneCards Identifiers for DLL4 Gene

  • GC15P036589
  • GC15P034117
  • GC15P038800
  • GC15P038937
  • GC15P039008
  • GC15P041221
  • GC15P018070

Summaries for DLL4 Gene

Entrez Gene Summary for DLL4 Gene

  • This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLL4 Gene

DLL4 (Delta-Like 4 (Drosophila)) is a Protein Coding gene. Diseases associated with DLL4 include adams-oliver syndrome 6 and adams-oliver syndrome. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is JAG1.

UniProtKB/Swiss-Prot for DLL4 Gene

  • Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

Gene Wiki entry for DLL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLL4 Gene

Genomics for DLL4 Gene

Regulatory Elements for DLL4 Gene

Promoters for DLL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLL4 Gene

Chromosome:
15
Start:
40,929,333 bp from pter
End:
40,939,072 bp from pter
Size:
9,740 bases
Orientation:
Plus strand

Genomic View for DLL4 Gene

Genes around DLL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLL4 Gene

Proteins for DLL4 Gene

  • Protein details for DLL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR61-DLL4_HUMAN
    Recommended name:
    Delta-like protein 4
    Protein Accession:
    Q9NR61
    Secondary Accessions:
    • Q3KP23
    • Q9NQT9

    Protein attributes for DLL4 Gene

    Size:
    685 amino acids
    Molecular mass:
    74605 Da
    Quaternary structure:
    • Binds to Notch-1 and Notch-4.

neXtProt entry for DLL4 Gene

Proteomics data for DLL4 Gene at MOPED

Post-translational modifications for DLL4 Gene

  • Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
  • Glycosylation at Asn 108, Asn 183, Asn 205, and Asn 393
  • Modification sites at PhosphoSitePlus

Other Protein References for DLL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DLL4 (DLL4)

No data available for DME Specific Peptides for DLL4 Gene

Domains & Families for DLL4 Gene

Suggested Antigen Peptide Sequences for DLL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NR61

UniProtKB/Swiss-Prot:

DLL4_HUMAN :
  • The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
Domain:
  • The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
  • Contains 1 DSL domain.
  • Contains 8 EGF-like domains.
genes like me logo Genes that share domains with DLL4: view

No data available for Gene Families for DLL4 Gene

Function for DLL4 Gene

Molecular function for DLL4 Gene

UniProtKB/Swiss-Prot Function:
Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

LifeMap Function Summary for DLL4 Gene

During embryonic development, DLL4 as signaling molecule is secreted from the following cells
It affects the following cells:
genes like me logo Genes that share phenotypes with DLL4: view

Human Phenotype Ontology for DLL4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DLL4 Gene

MGI Knock Outs for DLL4:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DLL4 Gene

Localization for DLL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLL4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLL4 Gene COMPARTMENTS Subcellular localization image for DLL4 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DLL4 Gene

Pathways & Interactions for DLL4 Gene

genes like me logo Genes that share pathways with DLL4: view

Pathways by source for DLL4 Gene

1 KEGG pathway for DLL4 Gene
1 GeneGo (Thomson Reuters) pathway for DLL4 Gene
1 R&D Systems pathway for DLL4 Gene

SIGNOR curated interactions for DLL4 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001525 angiogenesis IEA,ISS --
GO:0001974 blood vessel remodeling IEA,ISS --
GO:0003208 cardiac ventricle morphogenesis IEA,ISS --
GO:0003344 pericardium morphogenesis IEA,ISS --
genes like me logo Genes that share ontologies with DLL4: view

Drugs & Compounds for DLL4 Gene

(2) Drugs for DLL4 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
DEMCIZUMAB Pharma 0
REGN421 Pharma other, Inhibitor Other, Notch pathway inhibitors 0

(1) Additional Compounds for DLL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLL4: view

Transcripts for DLL4 Gene

mRNA/cDNA for DLL4 Gene

Unigene Clusters for DLL4 Gene

Delta-like 4 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLL4 Gene

No ASD Table

Relevant External Links for DLL4 Gene

GeneLoc Exon Structure for
DLL4
ECgene alternative splicing isoforms for
DLL4

Expression for DLL4 Gene

mRNA expression in normal human tissues for DLL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DLL4 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DLL4 Gene



SOURCE GeneReport for Unigene cluster for DLL4 Gene Hs.511076

mRNA Expression by UniProt/SwissProt for DLL4 Gene

Q9NR61-DLL4_HUMAN
Tissue specificity: Expressed in vascular endothelium.
genes like me logo Genes that share expression patterns with DLL4: view

Protein tissue co-expression partners for DLL4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DLL4 Gene

Orthologs for DLL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLL4 35
  • 90.36 (n)
  • 92.41 (a)
DLL4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLL4 35
  • 90.85 (n)
  • 92.7 (a)
DLL4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dll4 35
  • 86.07 (n)
  • 87.03 (a)
Dll4 16
Dll4 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLL4 35
  • 99.51 (n)
  • 99.56 (a)
DLL4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dll4 35
  • 86.86 (n)
  • 86.72 (a)
oppossum
(Monodelphis domestica)
Mammalia DLL4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLL4 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLL4 35
  • 71.44 (n)
  • 70.43 (a)
DLL4 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLL4 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dll4 35
  • 64.87 (n)
  • 63.73 (a)
zebrafish
(Danio rerio)
Actinopterygii dll4 35
  • 62.47 (n)
  • 58.59 (a)
dll4 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta C901 37
  • 37 (a)
CG15388 37
  • 38 (a)
Dl 37
  • 44 (a)
Dl 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apx-1 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
CSA.7799 36
  • 32 (a)
ManyToMany
Species with no ortholog for DLL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLL4 Gene

ENSEMBL:
Gene Tree for DLL4 (if available)
TreeFam:
Gene Tree for DLL4 (if available)

Paralogs for DLL4 Gene

Paralogs for DLL4 Gene

(4) SIMAP similar genes for DLL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DLL4: view

Variants for DLL4 Gene

Sequence variations from dbSNP and Humsavar for DLL4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2277538 -- 40,934,852(+) CATCC(C/T)TGCCC intron-variant
rs4244583 -- 40,932,856(+) CTGTC(C/T)GGTGG intron-variant
rs3212277 -- 40,929,827(+) CCTTC(C/T)CTCGG intron-variant
rs3212278 -- 40,931,926(+) CTCCT(A/G)TCTCT intron-variant
rs3212279 -- 40,932,082(+) GGAGA(A/G/T)CTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLL4 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
nsv904104 CNV Loss 21882294
nsv904106 CNV Loss 21882294
nsv1504 CNV Insertion 18451855

Variation tolerance for DLL4 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLL4 Gene

HapMap Linkage Disequilibrium report
DLL4
Human Gene Mutation Database (HGMD)
DLL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLL4 Gene

Disorders for DLL4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DLL4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
adams-oliver syndrome 6
  • aos6
adams-oliver syndrome
  • adams oliver syndrome
aplasia cutis congenita
  • acc
oliver syndrome
  • postaxial polydactyly-intellectual disability syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DLL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLL4
genes like me logo Genes that share disorders with DLL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLL4 Gene

Publications for DLL4 Gene

  1. Dll4, a novel Notch ligand expressed in arterial endothelium. (PMID: 10837024) Shutter J.R. … Stark K.L. (Genes Dev. 2000) 2 3 4 23 67
  2. [Influence of Delta-like ligand 4/Notch signal transduction pathway upon the biological behavior of human umbilical vein endothelial cells]. (PMID: 20193271) Chen L. … Li T. (Zhonghua Yi Xue Za Zhi 2009) 3 23
  3. Expression of Delta-like protein 4 in the human endometrium. (PMID: 17916635) Mazella J. … Tseng L. (Endocrinology 2008) 3 23
  4. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. (PMID: 18339870) Williams C.K. … Harris A.L. (Cancer Res. 2008) 3 23
  5. Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth. (PMID: 18577711) Segarra M. … Tosato G. (Blood 2008) 3 23

Products for DLL4 Gene

Sources for DLL4 Gene

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