Aliases for DLL4 Gene
External Ids for DLL4 Gene
Previous GeneCards Identifiers for DLL4 Gene
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLL4 Gene
DLL4 (Delta Like Canonical Notch Ligand 4) is a Protein Coding gene. Diseases associated with DLL4 include Adams-Oliver Syndrome 6 and Aplasia Cutis Congenita, Nonsyndromic. Among its related pathways are Notch signaling pathway (KEGG) and Signaling by NOTCH1. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is DLL1.
UniProtKB/Swiss-Prot for DLL4 Gene
Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).