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DLL4 Gene

protein-coding   GIFtS: 59
GCID: GC15P041221

Delta-Like 4 (Drosophila)

(Previous name: delta-like 4 homolog (Drosophila))
  Search for DLL4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Delta-Like 4 (Drosophila)1 2     Delta-Like Protein 42
Drosophila Delta Homolog 42 3     delta42
Delta-Like 4 Homolog (Drosophila)1     hdelta22
Delta 42     Notch Ligand Delta-22
Delta Ligand 42     Notch Ligand DLL42
Delta-Like 4 Homolog2     Delta43
Delta-Like 4 Protein2     

External Ids:    HGNC: 29101   Entrez Gene: 545672   Ensembl: ENSG000001289177   OMIM: 6051855   UniProtKB: Q9NR613   

Export aliases for DLL4 gene to outside databases

Previous GC identifers: GC15P036589 GC15P034117 GC15P038800 GC15P038937 GC15P039008 GC15P018070


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLL4 Gene:
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are
characterized by a DSL domain, EGF repeats, and a transmembrane domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLL4 Gene:
DLL4 (delta-like 4 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include Notch binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: DLL4_HUMAN, Q9NR61
Function: Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and
angiogenic sprouting. Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity)

Gene Wiki entry for DLL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLL4 gene promoter:
         HEN1   Pax-5   p53   STAT3   Nkx2-5   ATF   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLL4 promoter sequence
   Search Chromatin IP Primers for DLL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

DLL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLL4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041221:  view genomic region     (about GC identifiers)

Start:
41,221,531 bp from pter      End:
41,231,258 bp from pter
Size:
9,728 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DLL4_HUMAN, Q9NR61 (See protein sequence)
Recommended Name: Delta-like protein 4 precursor  
Size: 685 amino acids; 74605 Da
Subunit: Binds to Notch-1 and Notch-4 (By similarity)
Secondary accessions: Q3KP23 Q9NQT9

Explore the universe of human proteins at neXtProt for DLL4: NX_Q9NR61

Explore proteomics data for DLL4 at MOPED

Post-translational modifications: 

  • Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity)1
  • Glycosylation2 at Asn108, Asn183, Asn205, Asn393
  • Modification sites at PhosphoSitePlus

  • See DLL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061947.1  
    ENSEMBL proteins: 
     ENSP00000249749  
    Reactome Protein details: Q9NR61

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for DLL4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001774 DSL
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR011651 Notch_ligand_N
     IPR001881 EGF-like_Ca-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NR61

    ProtoNet protein and cluster: Q9NR61

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001774 Delta/Serrate/lag-2 (DSL) protein
    IPB001881 EGF-like calcium-binding
    IPB011651 Notch ligand
    IPB013111 EGF


    UniProtKB/Swiss-Prot: DLL4_HUMAN, Q9NR61
    Domain: The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor
    Similarity: Contains 1 DSL domain
    Similarity: Contains 8 EGF-like domains


    Find genes that share domains with DLL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLL4_HUMAN, Q9NR61
    Function: Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and
    angiogenic sprouting. Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity)

         Summary: 

    During embryonic development, DLL4 as signaling molecule is secreted from the following cells:
                
    Endothelium: Endothelial Tip Cells (Arteries)
    Eye: Early Amacrine Horizontal Precursor Cells (Retinal Neuroblastic Layer)

    It affects the following cells:
    Endothelium: Arterial Endothelial Cells (Arteries)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005112Notch binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DLL4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DLL4:
     Lamellipodia cells 

         11 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Dll4):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  normal 
     vision/eye 

    Find genes that share phenotypes with DLL4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dll4tm1Grid for DLL4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLL4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLL4

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DLL4 (see all 55):
    hsa-miR-520f hsa-miR-300 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-650 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidDLL4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DLL4 (NM_019074)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLL4_HUMAN, Q9NR61: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DLL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DLL4 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Signaling by NOTCH30.00
    Notch Signaling Pathway0.84
    Signaling by NOTCH40.00
    Delta-Notch Signaling Pathway0.33
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    3Signaling by NOTCH2
    NOTCH2 Activation and Transmission of Signal to the Nucleus0.67
    Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1-M1580_K2555) Translocation Mutant0.00
    Signaling by NOTCH20.67
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.00
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    4Signaling by GPCR
    Signal Transduction0.58
    5Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50


    Find genes that share SuperPaths with DLL4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DLL4
        Notch Signaling Pathways


    2 Cell Signaling Technology (CST) Pathways for DLL4
        Wnt / Hedgehog / Notch
    Angiogenesis

    1 GeneGo (Thomson Reuters) Pathway for DLL4
        Development Notch Signaling Pathway

    4 BioSystems Pathways for DLL4
        Notch Signaling Pathway
    Neural Crest Differentiation
    Delta-Notch Signaling Pathway
    Notch signaling pathway

    1 Sino Biological Pathway for DLL4
        Notch Signaling Pathway

    Selected Reactome Pathways for DLL4 (see all 8)
        NOTCH2 Activation and Transmission of Signal to the Nucleus
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Signaling by NOTCH4
    Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    Signaling by NOTCH3


    1 Kegg Pathway  (Kegg details for DLL4):
        Notch signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLL4: 
              Terminal Differentiation Markers in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DLL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DLL4 (Q9NR613 ENSP000002497494) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOTCH4Q994663, ENSP000003641634I2D: score=1 STRING: ENSP00000364163
    ENSG00000223355Q994663I2D: score=1 
    ENSG00000234876Q994663I2D: score=1 
    ENSG00000238196Q994663I2D: score=1 
    NOTCH1P465313, ENSP000002775414I2D: score=1 STRING: ENSP00000277541
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    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001525angiogenesis ISS--
    GO:0001569patterning of blood vessels ISS--
    GO:0001974blood vessel remodeling ISS--
    GO:0003208cardiac ventricle morphogenesis ISS--

    Find genes that share ontologies with DLL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLL4

    1 Novoseek inferred chemical compound relationship for DLL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 55.6 26 19844231 (4), 18056450 (2), 18339870 (2), 18545664 (2) (see all 8)



    Find genes that share compounds with DLL4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DLL4 gene: 
    NM_019074.3  

    Unigene Cluster for DLL4:

    Delta-like 4 (Drosophila)
    Hs.511076  [show with all ESTs]
    Unigene Representative Sequence: NM_019074
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557876 ENST00000249749(uc001zng.2) ENST00000559440
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DLL4 (see all 55):
    hsa-miR-520f hsa-miR-300 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-650 hsa-miR-124
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    Additional mRNA sequence: 

    AB036931.1 AB043894.1 AF253468.1 AF279305.1 AK313831.1 AY358894.1 BC106950.2 

    4 DOTS entries:

    DT.210949  DT.100811595  DT.95092163  DT.95305042 

    Selected AceView cDNA sequences (see all 84):

    AI160980 BI820351 BF061793 AF279305 AB036931 AF253468 AB043894 BX377313 
    AW274822 AY358894 AI307188 AW594704 AI478830 AI191246 AW072549 BI820784 
    CA394151 NM_019074 CA866301 BE217898 BF224313 BI772452 AI819931 BE552365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCCAACTA
    DLL4 Expression
    About this image


    DLL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord Cells Notochord
     
     Cartilage (Muscoskeletal System)
             Notochord Cells Notochord
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Coronary Vessels
     
     Endothelium (Cardiovascular System)
             Angioblasts Embryonic Capillary Plexus
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
    DLL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511076

    UniProtKB/Swiss-Prot: DLL4_HUMAN, Q9NR61
    Tissue specificity: Expressed in vascular endothelium

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLL4: 
              Terminal Differentiation Markers in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLL4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dll41 , 5 delta-like 4 (Drosophila)1, 5 86.07(n)1
    87.03(a)1
      2 (59.97 cM)5
    544851  NM_019454.31  NP_062327.21 
     1193257845 
    chicken
    (Gallus gallus)
    Aves DLL41 delta-like 4 (Drosophila) 71.44(n)
    70.43(a)
      423208  XM_421132.4  XP_421132.2 
    lizard
    (Anolis carolinensis)
    Reptilia DLL46
    delta-like 4 (Drosophila)
    61(a)
    1 ↔ 1
    GL343264.1(49034-68091)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dll41 delta-like 4 (Drosophila) 64.87(n)
    63.73(a)
      100489166  XM_002939550.2  XP_002939596.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dll41 delta-like 4 (Drosophila) 62.47(n)
    58.59(a)
      563920  NM_001079835.1  NP_001073304.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dl3 antennal morphogenesis Notch binding 44(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for DLL4 (if available)
    TreeFam Gene Tree for DLL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLL4 gene
    DLK22  SNED12  NOTCH42  NOTCH12  DLL32  NOTCH32  JAG22  CRB22  
    DLK12  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    4 SIMAP similar genes for DLL4 using alignment to 1 protein entry:     DLL4_HUMAN:
    JAG1    DLL1    JAG2    DLK1

    Find genes that share paralogs with DLL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLL4 (see all 276)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1892596371,2
    --41219725(+) CAGGGA/TTCCAT 1 -- us2k10--------
    rs779555271,2
    --41219787(+) AGGCAC/TGCCCC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1810043161,2
    --41219802(+) TCCCCC/TTCCCT 1 -- us2k10--------
    rs1128297411,2
    C,F--41220026(+) CCCCCC/GCCCAC 1 -- us2k13Minor allele frequency- G:0.11NA CSA 124
    rs801873881,2
    C--41220393(+) GGGCCA/TCCCAG 1 -- us2k10--------
    rs1850716231,2
    --41220845(+) GCACGC/TCCCCC 1 -- us2k10--------
    rs1895855721,2
    --41220896(+) GGCCCC/TGAGCC 1 -- us2k10--------
    rs115745221,2
    C,H--41220900(+) CCGAGC/ACTTAG 1 -- us2k16Minor allele frequency- A:0.00NA NS EA 410
    rs1811261161,2
    --41220908(+) TAGACC/TCTTAG 1 -- us2k10--------
    rs560973741,2
    C,F--41220969(+) TTCCCT/CGCTGC 1 -- us2k11Minor allele frequency- C:0.05NA 120

    HapMap Linkage Disequilibrium report for DLL4 (41221531 - 41231258 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DLL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1504CNV Insertion18451855
    dgv2360n71CNV Loss21882294
    nsv904106CNV Loss21882294
    nsv904104CNV Loss21882294
    nsv904101CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLL4
    DNA2.0 Custom Variant and Variant Library Synthesis for DLL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605185    OMIM disorders: --


    Find genes that share disorders with DLL4           About GenesLikeMe

    1 Novoseek inferred disease relationship for DLL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 21.4 29 18056450 (5), 20103680 (4), 18577711 (3), 18758482 (2) (see all 7)


    Export disorders for DLL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLL4 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with DLL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dll4, a novel Notch ligand expressed in arterial endothelium. (PubMed id 10837024)1, 2, 3, 9 Shutter J.R.... Stark K.L. (Genes Dev. 2000)
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Molecular cloning of Delta-4, a new mouse and human Notch ligand. (PubMed id 11134954)1, 2 Yoneya T....Nishikawa M. (J. Biochem. 2001)
    6. Expression of Delta-like protein 4 in the human endometrium. (PubMed id 17916635)1, 9 Mazella J....Tseng L. (Endocrinology 2008)
    7. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. (PubMed id 16914569)1, 9 Patel N.S....Harris A.L. (Clin. Cancer Res. 2006)
    8. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. (PubMed id 18339870)1, 9 Williams C.K....Harris A.L. (Cancer Res. 2008)
    9. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. (PubMed id 18056450)1, 9 Li J.L....Harris A.L. (Cancer Res. 2007)
    10. [Influence of Delta-like ligand 4/Notch signal transduction pathway upon the biological behavior of human umbilical vein endothelial cells]. (PubMed id 20193271)1, 9 Chen L....Li T. (Zhonghua Yi Xue Za Zhi 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54567 HGNC: 2910 AceView: DLL4 Ensembl:ENSG00000128917 euGenes: HUgn54567
    ECgene: DLL4 Kegg: 54567 H-InvDB: DLL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DLL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DLL4 gene:
    Search GeneIP for patents involving DLL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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