DLL4 Gene

Aliases
for DLL4 gene

Previous GC identifers: GC15P036589 GC15P034117 GC15P038800 GC15P038937 GC15P039008 GC15P018070

Summaries
for DLL4 gene

Genomic Views
for DLL4 gene

RefSeq DNA sequence:

NC_000015.9  NC_018926.1  NT_010194.17  

SwitchGear Promoter luciferase reporter plasmid: DLL4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLL4

DLL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041221:  view genomic region     (about GC identifiers)

Proteins
for DLL4 gene

Explore the universe of human proteins at neXtProt for DLL4: NX_Q9NR61

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for DLL4
	Enzo Life Sciences proteins for DLL4
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for DLL4
	GenScript Custom Purified and Recombinant Proteins Services for DLL4
	Novus Biologicals DLL4 Protein
	Sino Biological Recombinant Protein for DLL4
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DLL4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DLL4
	R&D Systems Antibodies for DLL4
	Cell Signaling Technology (CST) Antibodies for DLL4
	Browse OriGene Antibodies OriGene Custom Antibody Services for DLL4
	GenScript Custom Superior Antibodies Services for DLL4
	Novus Biologicals DLL4 Antibodies
	Search for Antibodies for DLL4 at Abcam
	Uscn Antibodies for DLL4
	ThermoFisher Antibody for DLL4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DLL4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DLL4

Protein Domains /
Families
for DLL4 gene

ProtoNet protein and cluster: Q9NR61

Function
for DLL4 gene

     Summary:  

miRNA Products:		OriGene 3'-UTR Clone: DLL4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLL4
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate DLL4 (see all 55):
		hsa-miR-520f hsa-miR-300 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-650 hsa-miR-124
		SwitchGear 3'UTR luciferase reporter plasmid: DLL4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLL4 (see all 7) OriGene shRNA RFP: DLL4 OriGene siRNA: DLL4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLL4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for DLL4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLL4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLL4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DLL4 (NM_019074)
		Sino Biological Human cDNA Clone for DLL4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLL4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLL4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DLL4
		Search LifeMap BioReagents cell lines for DLL4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 7 alleles) (MGI details for Dll4)

Pathways & Interactions
for DLL4 gene

	Super-pathway	contained gene-specific pathways
1	Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	8/10 pathways (see all 10) Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant 1.00 FBXW7 Mutants and NOTCH1 in Cancer 1.00 Signaling by NOTCH1 PEST Domain Mutants in Cancer 1.00 Signaling by NOTCH1 1.00 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 1.00 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.79 Signaling by NOTCH1 in Cancer 1.00 Signaling by NOTCH 0.77
2	NOTCH2 Activation and Transmission of Signal to the Nucleus	NOTCH2 Activation and Transmission of Signal to the Nucleus 1.00 Activated NOTCH1 Transmits Signal to the Nucleus 0.58 Signaling by NOTCH2 1.00 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor 0.43 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.62 Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant 0.24
3	Notch Signaling Pathway	Notch Signaling Pathway 1.00 Delta-Notch Signaling Pathway 0.27 Notch signaling pathway 0.82
4	Development_Notch Signaling Pathway	Development_Notch Signaling Pathway 1.00 Development Notch Signaling Pathway 0.97
5	Signaling by NOTCH3	Signaling by NOTCH3 1.00 Signaling by NOTCH4 0.83

1 EMD Millipore Pathway for DLL4

Development Notch Signaling Pathway

2 Cell Signaling Technology (CST) Pathways for DLL4

	Wnt / Hedgehog / Notch
	Angiogenesis

1 GeneGo (Thomson Reuters) Pathway for DLL4

Development Notch Signaling Pathway

4 BioSystems Pathways for DLL4

	Neural Crest Differentiation
	Notch Signaling Pathway
	Delta-Notch Signaling Pathway
	Notch signaling pathway

5/21        Reactome Pathways for DLL4

	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	FBXW7 Mutants and NOTCH1 in Cancer
	Signaling by NOTCH1 HD Domain Mutants in Cancer
	Signaling by NOTCH1 in Cancer
	Disease

1         Kegg Pathway  (Kegg details for DLL4)

Notch signaling pathway

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

Drugs & Compounds
for DLL4 gene

Transcripts
for DLL4 gene

Expression
for DLL4 gene

DLL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCCAACTA

10 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Primitive StreakNotochordNotochord Cells			Cartilage
	CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells			Cartilage
	CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells			Cartilage
	CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells			Cartilage
	CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus Cells			Cartilage
	EndotheliumArteriesEndothelial tip cells			Endothelium
	EyeNeuroblastic LayerEarly Amacrine Horizontal Precursor Cells			Amacrine, Horizontal, Retina
	EyeNeuroblastic LayerLate Amacrine Horizontal Precursor Cells			Amacrine, Retina
	Lateral Plate MesodermEmbryonic Capillary PlexusAngioblasts			Endothelium
	Lateral Plate MesodermPaired Dorsal AortaArterial endothelial cells			Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLL4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DLL4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLL4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLL4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL4

Orthologs
for DLL4 gene

Paralogs
for DLL4 gene

Paralogs for DLL4 gene

NOTCH4²  SNED1²  NOTCH1²  NOTCH3²  DLL3²  CRB2²  JAG2²  NOTCH2²  

JAG1²  DNER²  CRB1²  DLL1²  

4 SIMAP similar genes for DLL4 using alignment to 1 protein entry:     DLL4_HUMAN:

JAG1    DLL1    JAG2    DLK1

DLL4 for paralogs           About GeneDecksing

Genomic Variants
for DLL4 gene

10/157 NCBI SNPs in DLL4 are shown (see all 157)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1892596371,2		--	41219725(+)	CAGGGA/TTCCAT	1	--	us2k1		0	--	--	--	--
rs779555271,2		--	41219787(+)	AGGCAC/TGCCCC	1	--	us2k1		1		WA	118
rs1810043161,2		--	41219802(+)	TCCCCC/TTCCCT	1	--	us2k1		0	--	--	--	--
rs1128297411,2	C,F,	--	41220026(+)	CCCCCC/GCCCAC	1	--	us2k1		3		NA CSA	124
rs801873881,2	C	--	41220393(+)	GGGCCA/TCCCAG	1	--	us2k1		0	--	--	--	--
rs1850716231,2		--	41220845(+)	GCACGC/TCCCCC	1	--	us2k1		0	--	--	--	--
rs1895855721,2		--	41220896(+)	GGCCCC/TGAGCC	1	--	us2k1		0	--	--	--	--
rs115745221,2	C,H	--	41220900(+)	CCGAGC/ACTTAG	1	--	us2k1		6		NA NS EA	410
rs1811261161,2		--	41220908(+)	TAGACC/TCTTAG	1	--	us2k1		0	--	--	--	--
rs560973741,2	F,	--	41220969(+)	TTCCCT/CGCTGC	1	--	us2k1		1		NA	120

HapMap Linkage Disequilibrium report for DLL4 (41221531 - 41231258 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for DLL4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLL4

DNA2.0 Custom Variant and Variant Library Synthesis for DLL4

Disorders / Diseases
for DLL4 gene

13 diseases for DLL4

1 Novoseek disease relationship for DLL4 gene    About this table

Publications
for DLL4 gene

PubMed articles for DLL4 gene, integrated from 9 sources (see all 69): (articles sorted by number of sources associating them with DLL4)

Utopia: connect your pdf to the dynamic world of online information

1. Dll4, a novel Notch ligand expressed in arterial endothelium. (PubMed id 10837024)^{1, 2, 3, 9} Shutter J.R.... Stark K.L. (2000)
2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
5. Molecular cloning of Delta-4, a new mouse and human Notch ligand. (PubMed id 11134954)^{1, 2} Yoneya T....Nishikawa M. (2001)
6. Expression of Delta-like protein 4 in the human endometrium. (PubMed id 17916635)^{1, 9} Mazella J....Tseng L. (2008)
7. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. (PubMed id 16914569)^{1, 9} Patel N.S....Harris A.L. (2006)
8. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. (PubMed id 18339870)^{1, 9} Williams C.K....Harris A.L. (2008)
9. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. (PubMed id 18056450)^{1, 9} Li J.L....Harris A.L. (2007)
10. [Influence of Delta-like ligand 4/Notch signal transd uction pathway upon the biological behavior of human umbilical vein endothelial cells] (PubMed id 20193271)^{1, 9} Chen L....Li T. (2009)

External Searches for DLL4 gene

Genome Databases showing DLL4 gene

Other Databases showing DLL4 gene

Specialized Databases showing DLL4 gene

Products
for DLL4 gene