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Aliases for DLL4 Gene

Aliases for DLL4 Gene

  • Delta-Like 4 (Drosophila) 2 3
  • Drosophila Delta Homolog 4 3 4
  • Delta4 3 4
  • Delta-Like 4 Homolog (Drosophila) 2
  • Delta-Like 4 Homolog 3
  • Delta-Like 4 Protein 3
  • Delta-Like Protein 4 3
  • Notch Ligand Delta-2 3
  • Notch Ligand DLL4 3
  • Delta Ligand 4 3
  • Delta 4 3
  • Hdelta2 3

External Ids for DLL4 Gene

Summaries for DLL4 Gene

Entrez Gene Summary for DLL4 Gene

  • This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLL4 Gene

DLL4 (Delta-Like 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is NOTCH2.

UniProtKB/Swiss-Prot for DLL4 Gene

  • Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

Gene Wiki entry for DLL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLL4 Gene

Genomics for DLL4 Gene

Genomic Location for DLL4 Gene

Start:
40,929,333 bp from pter
End:
40,939,072 bp from pter
Size:
9,740 bases
Orientation:
Plus strand

Genomic View for DLL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLL4 Gene

Regulatory Elements for DLL4 Gene

Proteins for DLL4 Gene

  • Protein details for DLL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR61-DLL4_HUMAN
    Recommended name:
    Delta-like protein 4
    Protein Accession:
    Q9NR61
    Secondary Accessions:
    • Q3KP23
    • Q9NQT9

    Protein attributes for DLL4 Gene

    Size:
    685 amino acids
    Molecular mass:
    74605 Da
    Quaternary structure:
    • Binds to Notch-1 and Notch-4.

neXtProt entry for DLL4 Gene

Proteomics data for DLL4 Gene at MOPED

Post-translational modifications for DLL4 Gene

  • Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn108, Asn183, Asn205, and Asn393

Other Protein References for DLL4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DLL4 Gene

Domains for DLL4 Gene

UniProtKB/Swiss-Prot:

DLL4_HUMAN
Domain:
  • The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor:
    • Q9NR61
  • Contains 1 DSL domain.:
    • Q9NR61
  • Contains 8 EGF-like domains.:
    • Q9NR61
genes like me logo Genes that share domains with DLL4: view

No data available for Gene Families for DLL4 Gene

Function for DLL4 Gene

Molecular function for DLL4 Gene

UniProtKB/Swiss-Prot Function: Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

LifeMap Function Summary for DLL4 Gene

During embryonic development, DLL4 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for DLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DLL4: view
genes like me logo Genes that share phenotypes with DLL4: view

Animal Models for DLL4 Gene

MGI Knock Outs for DLL4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DLL4 Gene

Localization for DLL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLL4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLL4 Gene COMPARTMENTS Subcellular localization image for DLL4 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DLL4: view

Pathways for DLL4 Gene

genes like me logo Genes that share pathways with DLL4: view

Pathways by source for DLL4 Gene

1 Sino Biological pathway for DLL4 Gene
1 R&D Systems pathway for DLL4 Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for DLL4 Gene
2 Cell Signaling Technology pathways for DLL4 Gene

Gene Ontology (GO) - Biological Process for DLL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001525 angiogenesis ISS --
GO:0001569 patterning of blood vessels ISS --
GO:0001974 blood vessel remodeling ISS --
GO:0003208 cardiac ventricle morphogenesis ISS --
genes like me logo Genes that share ontologies with DLL4: view

Compounds for DLL4 Gene

(1) Novoseek inferred chemical compound relationships for DLL4 Gene

Compound -log(P) Hits PubMed IDs
vegf 55.6 15
genes like me logo Genes that share compounds with DLL4: view

Transcripts for DLL4 Gene

mRNA/cDNA for DLL4 Gene

Unigene Clusters for DLL4 Gene

Delta-like 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLL4 Gene

No ASD Table

Relevant External Links for DLL4 Gene

GeneLoc Exon Structure for
DLL4
ECgene alternative splicing isoforms for
DLL4

Expression for DLL4 Gene

mRNA expression in normal human tissues for DLL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DLL4 Gene

SOURCE GeneReport for Unigene cluster for DLL4 Gene Hs.511076

mRNA Expression by UniProt/SwissProt for DLL4 Gene

Q9NR61-DLL4_HUMAN
Tissue specificity: Expressed in vascular endothelium
genes like me logo Genes that share expressions with DLL4: view

Orthologs for DLL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLL4 36
  • 99.51 (n)
  • 99.56 (a)
DLL4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLL4 36
  • 90.36 (n)
  • 92.41 (a)
DLL4 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLL4 36
  • 90.85 (n)
  • 92.7 (a)
DLL4 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dll4 36
  • 86.07 (n)
  • 87.03 (a)
Dll4 16
Dll4 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLL4 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLL4 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dll4 36
  • 86.86 (n)
  • 86.72 (a)
chicken
(Gallus gallus)
Aves DLL4 36
  • 71.44 (n)
  • 70.43 (a)
DLL4 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLL4 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dll4 36
  • 64.87 (n)
  • 63.73 (a)
zebrafish
(Danio rerio)
Actinopterygii dll4 36
  • 62.47 (n)
  • 58.59 (a)
dll4 37
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dl 37
  • 32 (a)
OneToMany
Dl 38
  • 44 (a)
C901 38
  • 37 (a)
CG15388 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea apx-1 38
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
ManyToMany
CSA.7799 37
  • 32 (a)
ManyToMany
Species with no ortholog for DLL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLL4 Gene

ENSEMBL:
Gene Tree for DLL4 (if available)
TreeFam:
Gene Tree for DLL4 (if available)

Paralogs for DLL4 Gene

Selected SIMAP similar genes for DLL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DLL4: view

Variants for DLL4 Gene

Sequence variations from dbSNP and Humsavar for DLL4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs2277538 -- 40,934,852(+) CATCC(C/T)TGCCC intron-variant
rs3212277 -- 40,929,827(+) CCTTC(C/T)CTCGG intron-variant
rs3212278 -- 40,931,926(+) CTCCT(A/G)TCTCT intron-variant
rs3212279 -- 40,932,082(+) GGAGA(G/T)CTAGG intron-variant
rs3212280 -- 40,934,823(+) GGGCA(A/G)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLL4 Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
nsv904104 CNV Loss 21882294
nsv904106 CNV Loss 21882294
nsv1504 CNV Insertion 18451855

Relevant External Links for DLL4 Gene

HapMap Linkage Disequilibrium report
DLL4
Human Gene Mutation Database (HGMD)
DLL4

Disorders for DLL4 Gene

(1) Novoseek inferred disease relationships for DLL4 Gene

Disease -log(P) Hits PubMed IDs
tumors 21.4 18
genes like me logo Genes that share disorders with DLL4: view

No data available for UniProtKB/Swiss-Prot for DLL4 Gene

Publications for DLL4 Gene

  1. Dll4, a novel Notch ligand expressed in arterial endothelium. (PMID: 10837024) Shutter J.R. … Stark K.L. (Genes Dev. 2000) 2 3 4 23
  2. Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. (PMID: 12482957) Liu Z.J. … Herlyn M. (Mol. Cell. Biol. 2003) 3 23
  3. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. (PMID: 16914569) Patel N.S. … Harris A.L. (Clin. Cancer Res. 2006) 3 23
  4. Delta-like 4 induces notch signaling in macrophages: implications for inflammation. (PMID: 17533181) Fung E. … Aikawa M. (Circulation 2007) 3 23
  5. Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth. (PMID: 18577711) Segarra M. … Tosato G. (Blood 2008) 3 23

Products for DLL4 Gene

Sources for DLL4 Gene

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