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DLL3 Gene

protein-coding   GIFtS: 59
GCID: GC19P039989

Delta-Like 3 (Drosophila)

(Previous name: delta (Drosophila)-like 3)
  See DLL3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Delta-Like 3 (Drosophila)1 2     Delta-Like Protein 32
Drosophila Delta Homolog 32 3     delta32
SCDO12 5     Delta33
Delta (Drosophila)-Like 31     

External Ids:    HGNC: 29091   Entrez Gene: 106832   Ensembl: ENSG000000909327   OMIM: 6027685   UniProtKB: Q9NYJ73   

Export aliases for DLL3 gene to outside databases

Previous GC identifers: GC19P040630 GC19P040380 GC19P044665 GC19P044682 GC19P044683 GC19P044684 GC19P036435


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLL3 Gene:
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are
characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal
recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLL3 Gene:
DLL3 (delta-like 3 (Drosophila)) is a protein-coding gene. Diseases associated with DLL3 include dll3-related spondylocostal dysostosis, autosomal recessive, and spondylocostal dysostosis 1. GO annotations related to this gene include Notch binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7
Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation
pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By
similarity)

Gene Wiki entry for DLL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLL3 gene promoter:
         E2F-4   E2F-3a   Pax-5   E2F-2   c-Ets-1   CREB   RORalpha1   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLL3 promoter sequence
   Search Chromatin IP Primers for DLL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

DLL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039989:  view genomic region     (about GC identifiers)

Start:
39,989,535 bp from pter      End:
39,999,121 bp from pter
Size:
9,587 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7 (See protein sequence)
Recommended Name: Delta-like protein 3 precursor  
Size: 618 amino acids; 64618 Da
Subunit: Can bind and activate Notch-1 or another Notch receptor (By similarity)
Secondary accessions: E9PFG2 Q8NBS4
Alternative splicing: 2 isoforms:  Q9NYJ7-1   Q9NYJ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLL3: NX_Q9NYJ7

Explore proteomics data for DLL3 at MOPED

Post-translational modifications: 

  • Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity)1
  • Modification sites at neXtProt

  • See DLL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_058637.1  NP_982353.1  

    ENSEMBL proteins: 
     ENSP00000348810   ENSP00000471688   ENSP00000205143  

    DLL3 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DLL3 

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    Search eBioscience for ELISAs for DLL3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR011651 Notch_ligand_N
     IPR009030 Growth_fac_rcpt_N_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q9NYJ7

    ProtoNet protein and cluster: Q9NYJ7

    5 Blocks protein domains:
    IPB001438 Type II EGF-like signature
    IPB001774 Delta/Serrate/lag-2 (DSL) protein
    IPB001881 EGF-like calcium-binding
    IPB006210 Type I EGF
    IPB011651 Notch ligand


    UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7
    Domain: The DSL domain is required for binding to the Notch receptor
    Similarity: Contains 1 DSL domain
    Similarity: Contains 6 EGF-like domains


    Find genes that share domains with DLL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLL3_HUMAN, Q9NYJ7
    Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation
    pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005112Notch binding NAS10742114
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DLL3           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dll3):
     behavior/neurological  craniofacial  embryogenesis  growth/size/body  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  muscle  nervous system  reproductive system 
     skeleton  vision/eye 

    Find genes that share phenotypes with DLL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dll3tm1Rbe for DLL3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLL3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLL3

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate DLL3:
    hsa-miR-525-5p hsa-miR-486-3p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidDLL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DLL3

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLL3

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    eBioscience FlowRNA Probe Sets ( VA1-12014) for DLL3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLL3_HUMAN, Q9NYJ7: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    extracellular1
    lysosome1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS10742114

    Find genes that share ontologies with DLL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DLL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Notch Signaling Pathways
    Notch Signaling Pathways
    4Notch signaling pathway (Pathway Interaction Database)
    Notch signaling pathway
    5Neural Crest Differentiation
    Neural Crest Differentiation


    Find genes that share SuperPaths with DLL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DLL3
        Notch Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for DLL3
        Wnt / Hedgehog / Notch

    3 BioSystems Pathways for DLL3
        Notch Signaling Pathway
    Neural Crest Differentiation
    Notch signaling pathway


    1 Kegg Pathway  (Kegg details for DLL3):
        Notch signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLL3: 
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DLL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for DLL3 (ENSP000002051434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLL1ENSP000003557184STRING: ENSP00000355718
    JAG1ENSP000002549584STRING: ENSP00000254958
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    ENSG00000235396ENSP000004106744STRING: ENSP00000410674
    NOTCH3ENSP000002633884STRING: ENSP00000263388
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IMP10742114
    GO:0001756somitogenesis IEA--
    GO:0007219Notch signaling pathway IEA--
    GO:0007275multicellular organismal development ----
    GO:0007386compartment pattern specification IEA--

    Find genes that share ontologies with DLL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DLL3 gene (2 alternative transcripts): 
    NM_016941.3  NM_203486.2  

    Unigene Cluster for DLL3:

    Delta-like 3 (Drosophila)
    Hs.127792  [show with all ESTs]
    Unigene Representative Sequence: NM_016941
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600437 ENST00000356433(uc010egq.3 uc002olw.2) ENST00000596614
    ENST00000600579 ENST00000205143(uc002olx.2)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate DLL3:
    hsa-miR-525-5p hsa-miR-486-3p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidDLL3 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DLL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLL3
      QuantiTect SYBR Green Assays in human, mouse, rat DLL3
      QuantiFast Probe-based Assays in human, mouse, rat DLL3
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12014) for DLL3 

    Additional mRNA sequence: 

    AK075302.1 AK308460.1 BC000218.2 

    6 DOTS entries:

    DT.97776220  DT.95363641  DT.100037331  DT.91768493  DT.91768495  DT.95363643 

    Selected AceView cDNA sequences (see all 197):

    AW043985 AI589616 CD106317 AW005292 AI650536 AI089759 AI364368 BX333040 
    BE218585 AW005449 NM_203486 AI871239 BE464716 BM715823 AI492259 D81716 
    D81705 AI570661 AI089793 BE222462 NM_016941 BQ881050 BQ420593 AI197794 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DLL3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:              -                                                         
    SP2:              -                                                         
    SP3:              -                 -     -     -                           
    SP4:                                                                        


    ECgene alternative splicing isoforms for DLL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCGCGGT
    DLL3 Expression
    About this image


    DLL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord Cells Notochord
     
     Cartilage (Muscoskeletal System)
             Notochord Cells Notochord
     
     Neural Tube (Nervous System)
             Mesencephalon
    DLL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127792
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLL3: 
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLL3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dll31 , 5 delta-like 3 (Drosophila)1, 5 81.65(n)1
    83.59(a)1
      7 (16.67 cM)5
    133891  NM_007866.21  NP_031892.21 
     282935535 
    fruit fly
    (Drosophila melanogaster)
    Insecta wry6
    weary
    10(a)
    1 → many
    2L(1836630-1858550)


    ENSEMBL Gene Tree for DLL3 (if available)
    TreeFam Gene Tree for DLL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLL3 gene
    DLK22  SNED12  NOTCH42  NOTCH12  NOTCH32  DLL42  JAG22  CRB22  
    DLK12  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    4 SIMAP similar genes for DLL3 using alignment to 2 protein entries:     DLL3_HUMAN (see all proteins):
    F9    NOTCH3    CUBN    SNED1

    Find genes that share paralogs with DLL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLL3 (see all 324)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0099524
    Spondylocostal dysostosis 1, autosomal recessive (SCDO1)4--see VAR_0099522 G D mis40--------
    rs557412531,2,,4
    Cnon-pathogenic140143157(+) GAGCCT/AGCTGG 4 /Q /L mis13Minor allele frequency- A:0.06WA NA 240
    rs81071271,2,,4
    C,Fnon-pathogenic140143247(+) GCGCTT/GCTCGT 4 /C /F mis1 ese35Minor allele frequency- G:0.16NA CSA WA EA 244
    rs11106271,2,,4
    C,F,A,Hnon-pathogenic140144398(-) ACACCG/ACTATG 4 /P /L mis131Minor allele frequency- A:0.41EA MN NS NA WA CSA EU 9908
    rs146351,2
    Cnon-pathogenic140147817(+) CGTGCG/TCCGCC 4 R L mis1 ese31Minor allele frequency- T:0.00MN 184
    rs1048946751,2
    Cpathogenic140144457(+) AATGCC/TGATGC 4 R * stg11Minor allele frequency- T:0.00NA 4544
    rs1048946741,2
    Cpathogenic140147424(+) CGCGGA/GTCCTC 4 D G mis10--------
    rs1048946761,2
    Cpathogenic140147781(+) CGCGGA/GCGTGG 4 D G mis10--------
    rs760967191,2
    C--36434681(+) GGGGG-/A/GA  
            
    AAAAA
    2 -- us2k10--------
    rs3710788961,2
    C--39991073(+) CCCCC-/AAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for DLL3 (39989535 - 39999121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DLL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523856CNV Loss19592680
    dgv3863n71CNV Loss21882294
    dgv3864n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): DLL3
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing DLL3:
    Glioma
    SeqTarget long-range PCR primers for resequencing DLL3
    DNA2.0 Custom Variant and Variant Library Synthesis for DLL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602768   
    OMIM disorders: 277300  
    UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7
  • Spondylocostal dysostosis 1 (SCDO1) [MIM:277300]: An autosomal recessive condition of variable severity
    associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of
    vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine
    (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a
    dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated
    respiratory infections resulting in life-threatening complications in the first year of life. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 7 diseases for DLL3:    
    About MalaCards
    dll3-related spondylocostal dysostosis, autosomal recessive    spondylocostal dysostosis 1    cascade stomach    dysostosis
    spondylocostal dysostosis, autosomal recessive    syndactyly type 4    spondylocostal dysostosis

    3 diseases from the University of Copenhagen DISEASES database for DLL3:
    Spondylocostal dysostosis     Cascade stomach     Alagille syndrome

    Find genes that share disorders with DLL3           About GenesLikeMe

    2 Novoseek inferred disease relationships for DLL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dysostosis 92.6 4 15122512 (1), 11118901 (1), 10742114 (1), 12746394 (1)
    dysplasia 28.3 1 11923214 (1)

    GeneTests: DLL3
    GeneReviews: DLL3
    Genetic Association Database (GAD): DLL3
    Human Genome Epidemiology (HuGE) Navigator: DLL3 (3 documents)

    Export disorders for DLL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLL3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with DLL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. (PubMed id 10742114)1, 2, 3, 9 Bulman M.P.... Turnpenny P.D. (Nat. Genet. 2000)
    2. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. (PubMed id 11923214)1, 4, 9 Dunwoodie S.L....Beddington R.S. (Development 2002)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3. (PubMed id 10364530)1, 3 Turnpenny P.D....Ellard S. (Am. J. Hum. Genet. 1999)
    7. Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis. (PubMed id 12746394)1, 9 Turnpenny P.D....Ellard S. (J. Med. Genet. 2003)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Delta-likeA 3 is silenced by methylation and induces apoptosis in human hepatocellular carcinoma. (PubMed id 23337976)1 Maemura K....Otsuki Y. (Int. J. Oncol. 2013)
    10. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10683 HGNC: 2909 AceView: DLL3 Ensembl:ENSG00000090932 euGenes: HUgn10683
    ECgene: DLL3 Kegg: 10683 H-InvDB: DLL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DLL3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=DLL3[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DLL3 gene:
    Search GeneIP for patents involving DLL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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