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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DLL3 Gene

protein-coding GIFtS: 57
GCID: GC19P039989

delta-like 3 (Drosophila)

(Previous name: delta (Drosophila)-like 3 )

Explore 15 diseases affiliated with
DLL3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Delta-Like 3 (Drosophila)¹ ²		Delta-Like Protein 3²
SCDO1¹ ² ⁵		Delta3³
Drosophila Delta Homolog 3² ³		Delta3³
Delta (Drosophila)-Like 3¹

External Ids:	HGNC: 2909¹	Entrez Gene: 10683²	Ensembl: ENSG00000090932⁷	OMIM: 602768⁵	UniProtKB: Q9NYJ7³

Export aliases for DLL3 gene to outside databases

Previous GC identifers: GC19P040630 GC19P040380 GC19P044665 GC19P044682 GC19P044683 GC19P044684 GC19P036435

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLL3:

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are

characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal

recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for

this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7

Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway.

Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity)

Gene Wiki entry for DLL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DLL3 gene promoter:
E2F-4 E2F-3a Pax-5 E2F-2 c-Ets-1 CREB RORalpha1 E2F E2F-1 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLL3 promoter sequence

Search SABiosciences Chromatin IP Primers for DLL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

DLL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLL3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P039989: view genomic region (about GC identifiers)

Start:	39,989,557 bp from pter	End:	39,999,121 bp from pter
Size:	9,565 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7 (See protein sequence)

Recommended Name: Delta-like protein 3 precursor

Size: 618 amino acids; 64618 Da

Subunit: Can bind and activate Notch-1 or another Notch receptor (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (Probable)

Secondary accessions: E9PFG2 Q8NBS4

Alternative splicing: 2 isoforms: Q9NYJ7-1 Q9NYJ7-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLL3: NX_Q9NYJ7

Post-translational modifications:

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NYJ7

DLL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_058637.1 NP_982353.1

ENSEMBL proteins:

ENSP00000348810 ENSP00000205143

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for DLL3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	NAS	10742114

DLL3 for ontologies About GeneDecksing

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	ThermoFisher Antibody for DLL3

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	Uscn ELISAs and CLIAs for DLL3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DLL3 for domains About GeneDecksing

3 InterPro domains/families:

IPR000742 EG-like_dom

IPR013032 EGF-like_CS

IPR011651 Notch_ligand_N

Graphical View of Domain Structure for InterPro Entry Q9NYJ7

ProtoNet protein and cluster: Q9NYJ7

5 Blocks protein families:

IPB001438 Type II EGF-like signature

IPB001774 Delta/Serrate/lag-2 (DSL) protein

IPB001881 EGF-like calcium-binding

IPB006210 Type I EGF

IPB011651 Notch ligand

UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7

Domain: The DSL domain is required for binding to the Notch receptor

Similarity: Contains 1 DSL domain

Similarity: Contains 6 EGF-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7

Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway.

Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DLL3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLL3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate DLL3:
		hsa-miR-525-5p hsa-miR-486-3p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: DLL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLL3 (see all 7) OriGene shRNA RFP: DLL3 OriGene siRNA: DLL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLL3

Gene Editing
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLL3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DLL3
		Search LifeMap BioReagents cell lines for DLL3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005112	Notch binding	NAS	10742114
GO:0005515	protein binding	--	--

DLL3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Dll3^tm1Rbe for DLL3
     12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Dll3):

behavior/neurological	craniofacial	embryogenesis	growth/size	hearing/vestibular/ear
limbs/digits/tail	mortality/aging	muscle	nervous system	reproductive system
skeleton	vision/eye

DLL3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Notch Signaling Pathway

Notch Signaling Pathway

1.00

Notch signaling pathway

0.82

Neural Crest Differentiation

Neural Crest Differentiation

1.00

Notch signaling pathway

Notch signaling pathway

1.00

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for DLL3

Wnt / Hedgehog / Notch

3 BioSystems Pathways for DLL3

	Neural Crest Differentiation
	Notch Signaling Pathway
	Notch signaling pathway

1 Kegg Pathway (Kegg details for DLL3):

Notch signaling pathway

DLL3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DLL3

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for DLL3 (ENSP00000205143⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLL1	ENSP00000355718⁴	STRING: ENSP00000355718
JAG1	ENSP00000254958⁴	STRING: ENSP00000254958
NOTCH1	ENSP00000277541⁴	STRING: ENSP00000277541
NOTCH3	ENSP00000263388⁴	STRING: ENSP00000263388
--	ENSP00000410674⁴	STRING: ENSP00000410674

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IMP	10742114
GO:0001756	somitogenesis	IEA	--
GO:0007219	Notch signaling pathway	IEA	--
GO:0007275	multicellular organismal development	--	--
GO:0007386	compartment pattern specification	IEA	--

DLL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DLL3
Search CenterWatch for drugs/clinical trials and news about DLL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DLL3 gene (2 alternative transcripts):

NM_016941.3 NM_203486.2

Unigene Cluster for DLL3:

Delta-like 3 (Drosophila)

Hs.127792 [show with all ESTs]

Unigene Representative Sequence: NM_016941

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356433(uc010egq.3 uc002olw.2) ENST00000205143(uc002olx.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DLL3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLL3
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate DLL3:
		hsa-miR-525-5p hsa-miR-486-3p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: DLL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLL3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLL3

Additional cDNA sequence:

AK075302.1 AK308460.1 BC000218.2

6 DOTS entries:

DT.97776220 DT.95363641 DT.100037331 DT.91768493 DT.91768495 DT.95363643

24/197 AceView cDNA sequences (see all 197):

AI278864 AW006191 AI871239 BE464716 AW026360 AI571242 AW005292 BF477394

AI089793 AI553800 BE858628 N43992 AI197794 BE222462 AI422180 AW005449

AI075089 D81716 BM715823 AI089759 BQ881050 BG819137 BE218585 AI492259

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DLL3 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9
SP1:					-
SP2:					-
SP3:					-						-		-		-
SP4:

ECgene alternative splicing isoforms for DLL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DLL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGCGCGGT

About this image

DLL3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Primitive Streak

Notochord

Notochord Cells

Selective marker (cell-identifying gene)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Midbrain dopaminergic-like neurons (Generation of midbra...)

See DLL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DLL3

SOURCE GeneReport for Unigene cluster: Hs.127792

SABiosciences Expression via Pathway-Focused PCR Arrays including DLL3:

Notch Signaling Pathway in human mouse rat

Stem Cells in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DLL3 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	DLL3⁶	--	43(a)	1 ↔ 1	GL343635.1(251453-268700)
zebrafish (Danio rerio)	Actinopterygii	CABZ01041309.1⁶ dlb⁶ (see all 3)	deltaB (see all 3)	7(a) 35(a) (see all 3)	possible ortholog possible ortholog (see all 3)	21(4318106-4325054) 5(38294022-38301923)
fruit fly (Drosophila melanogaster)	Insecta	Dl⁶	Delta	19(a)	1 → many	3R(15128453-15151935)
worm (Caenorhabditis elegans)	Secernentea	tag-336⁶ Y69H2.2⁶ (see all 7)	Protein Y69H2.2 (see all 7)	8(a) 8(a) (see all 7)	possible ortholog possible ortholog (see all 7)	V(18650315-18656137) V(18628652-18636145)

ENSEMBL Gene Tree for DLL3 (if available)
TreeFam Gene Tree for DLL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DLL3 gene

NOTCH4² SNED1² NOTCH1² NOTCH3² DLL4² JAG2² CRB2² NOTCH2²

JAG1² DNER² CRB1² DLL1²

DLL3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55741253^1,2	C,	non-pathogenic	36439800(+)	`GAGCCT/AGCTGG`	4	/Q /L	mis¹		3		WA NA	240
rs14635^1,2	C	non-pathogenic	36444463(+)	`CGTGCG/TCCGCC`	4	R L	mis¹ ese³		1		MN	184
rs8107127^1,2	C,F,	non-pathogenic	39993560(+)	`GCGCTT/GCTCGT`	4	/C /F	mis¹ ese³		5		NA CSA WA EA	244
rs1110627^1,2	C,F,A,H,	non-pathogenic	39994711(-)	`ACACCG/ACTATG`	4	/P /L	mis¹		31		EA MN NS NA WA CSA EU	9908
rs104894675^1,2	C	pathogenic	36441100(+)	`AATGCC/TGATGC`	4	R *	stg¹		1		NA	4544
rs104894674^1,2	C	pathogenic	36444070(+)	`CGCGGA/GTCCTC`	4	D G	mis¹		0	--	--	--	--
rs104894676^1,2	C	pathogenic	36444427(+)	`CGCGGA/GCGTGG`	4	D G	mis¹		0	--	--	--	--
rs113177859^1,2		--	36434154(+)	`CTGGGG/ATTATA`	2	--	us2k¹		1		CSA	2
rs80271437^1,2	F,	--	36434950(+)	`CGAAGG/CGGGAG`	2	--	us2k¹		1		NA	120
rs73930736^1,2	C,F,	--	36435023(+)	`AGCTCC/TTCGCC`	2	--	us2k¹		3		WA CSA	122

HapMap Linkage Disequilibrium report for DLL3 (39989557 - 39999121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DLL3: --
Human Gene Mutation Database (HGMD): DLL3

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing DLL3:

Glioma

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLL3

DNA2.0 Custom Variant and Variant Library Synthesis for DLL3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DLL3 for disorders           About GeneDecksing

OMIM gene information: 602768
OMIM disorders: 277300
UniProtKB/Swiss-Prot: DLL3_HUMAN, Q9NYJ7

Defects in DLL3 are the cause of spondylocostal dysostosis type 1 (SCDO1) [MIM:277300]. An autosomal recessive

condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations

include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the

chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads

to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated

respiratory infections resulting in life-threatening complications in the first year of life

15 diseases for DLL3: About MalaCards

spondylocostal dysostosis dysostosis spondylocostal dysostosis, autosomal recessive hajdu-cheney syndrome

spondylocostal dysostosis 1 cascade stomach craniometaphyseal dysplasia birth defects

alagille syndrome cadasil chronic lymphocytic leukemia lymphocytic leukemia

scoliosis leukemia neuronitis

3 diseases from the University of Copenhagen DISEASES database for DLL3:

Spondylocostal dysostosis Cascade stomach Alagille syndrome

2 Novoseek disease relationships for DLL3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dysostosis	92.6	4	15122512 (1), 11118901 (1), 10742114 (1), 12746394 (1)
dysplasia	28.3	1	11923214 (1)

GeneTests: DLL3

Spondylocostal Dysostosis, Autosomal Recessive

Genetic Association Database (GAD): DLL3
Human Genome Epidemiology (HuGE) Navigator: DLL3 (3 documents)

Export disorders for DLL3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DLL3 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with DLL3)

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Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. (PubMed id 10742114)^{1, 2, 3, 9} Bulman M.P.... Turnpenny P.D. (2000)
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. (PubMed id 11923214)^{1, 4, 9} Dunwoodie S.L....Beddington R.S. (2002)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3. (PubMed id 10364530)^{1, 3} Turnpenny P.D....Ellard S. (1999)
Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis. (PubMed id 12746394)^{1, 9} Turnpenny P.D....Ellard S. (2003)
Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)¹ Casabonne D....de Sanjose S. (2010)
High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)¹ Yerges L.M....Zmuda J.M. (2009)
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. (PubMed id 18676613)¹ Heuss S.F....Logeat F. (2008)
Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho- Levin syndrome. (PubMed id 18485326)² Cornier A.S.... Pourquie O. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10683	HGNC: 2909	AceView: DLL3	Ensembl:ENSG00000090932	euGenes: HUgn10683
ECgene: DLL3	Kegg: 10683	H-InvDB: DLL3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DLL3	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DLL3

Intellectual Property for DLL3 gene
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Patent Information for DLL3 gene:
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delta-like 3 (Drosophila)

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delta-like 3 (Drosophila)

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