Aliases for DLL3 Gene
External Ids for DLL3 Gene
Previous GeneCards Identifiers for DLL3 Gene
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLL3 Gene
DLL3 (Delta-Like 3 (Drosophila)) is a Protein Coding gene. Diseases associated with DLL3 include spondylocostal dysostosis 1, autosomal recessive and spondylocostal dysostosis 1. Among its related pathways are Neural Crest Differentiation and Wnt / Hedgehog / Notch. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is NOTCH2.
UniProtKB/Swiss-Prot for DLL3 Gene
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).