Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DLL1 Gene

protein-coding   GIFtS: 65
GCID: GC06M170591

Delta-Like 1 (Drosophila)

(Previous name: delta (Drosophila)-like 1)
  See DLL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Delta-Like 1 (Drosophila)1 2     DL12
Drosophila Delta Homolog 12 3     Delta2
H-Delta-12 3     Delta-Like Protein 12
Delta (Drosophila)-Like 11     Delta13
DELTA12     

External Ids:    HGNC: 29081   Entrez Gene: 285142   Ensembl: ENSG000001987197   OMIM: 6065825   UniProtKB: O005483   

Export aliases for DLL1 gene to outside databases

Previous GC identifers: GC06M169786 GC06M170206 GC06M170447 GC06M170508 GC06M168099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DLL1 Gene:
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a
role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DLL1 Gene:
DLL1 (delta-like 1 (Drosophila)) is a protein-coding gene. Diseases associated with DLL1 include superficial basal cell carcinoma, and visceral leishmaniasis. GO annotations related to this gene include Notch binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548
Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell
lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell
precursor

Gene Wiki entry for DLL1 (Delta-like 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NT_187553.1  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLL1 gene promoter:
         NF-1/L   Tal-1   FOXD3   E47   GATA-1   Evi-1   HOXA5   STAT3   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLL1 promoter sequence
   Search Chromatin IP Primers for DLL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q13-q22.33

DLL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170591:  view genomic region     (about GC identifiers)

Start:
170,591,294 bp from pter      End:
170,599,697 bp from pter
Size:
8,404 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548 (See protein sequence)
Recommended Name: Delta-like protein 1 precursor  
Size: 723 amino acids; 78056 Da
Subunit: Interacts with Notch receptors
Secondary accessions: B2RAK7 Q9NU41 Q9UJV2

Explore the universe of human proteins at neXtProt for DLL1: NX_O00548

Explore proteomics data for DLL1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity)1
  • Glycosylation2 at Asn477
  • Modification sites at PhosphoSitePlus

  • See DLL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005609.3  
    ENSEMBL proteins: 
     ENSP00000355718  
    Reactome Protein details: O00548

    DLL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DLL1
    Enzo Life Sciences proteins for DLL1
    OriGene Purified Protein for DLL1
    OriGene Protein Over-expression Lysate for DLL1
    OriGene MassSpec for DLL1
    OriGene Custom Protein Services for DLL1
    GenScript Custom Purified and Recombinant Proteins Services for DLL1
    Novus Biologicals DLL1 Protein
    Novus Biologicals DLL1 Lysate
    Sino Biological Recombinant Protein for DLL1
    Sino Biological Cell Lysate for DLL1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DLL1 

    DLL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DLL1
    Cell Signaling Technology (CST) Antibodies for DLL1 
    OriGene Antibodies for DLL1
    OriGene Custom Antibody Services for DLL1
    Novus Biologicals DLL1 Antibodies
    Search for Antibodies for DLL1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for DLL1
    LSBio Antibodies in human, mouse, rat for DLL1

    DLL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DLL1
    R&D Systems ELISAs for DLL1
    GenScript Custom Assay Services for DLL1
    Enzo Life Sciences assays for DLL1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DLL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 8):
     IPR001774 DSL
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR011651 Notch_ligand_N

    Graphical View of Domain Structure for InterPro Entry O00548

    ProtoNet protein and cluster: O00548

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001438 Type II EGF-like signature
    IPB001774 Delta/Serrate/lag-2 (DSL) protein
    IPB001881 EGF-like calcium-binding
    IPB011651 Notch ligand


    UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548
    Similarity: Contains 1 DSL domain
    Similarity: Contains 8 EGF-like domains


    Find genes that share domains with DLL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLL1_HUMAN, O00548
    Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell
    lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell
    precursor

         Summary: 

    During embryonic development, DLL1 as signaling molecule is secreted from the following cells:
                
    Paraxial Mesoderm: Paraxial Mesoderm Cells (Paraxial Mesoderm)

    It affects the following cells:
    Somite: Muscle Progenitor Cells (Cervical Dorsomedial Dermomyotome Lip)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005112Notch binding IPI10079256
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10079256
         
    Find genes that share ontologies with DLL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DLL1:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Dll1) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  muscle 

    Find genes that share phenotypes with DLL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DLL1:
    hsa-mir-34a-5p (MIRT001757), hsa-mir-335-5p (MIRT017844)

    Block miRNA regulation of human, mouse, rat DLL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLL1 (see all 58):
    hsa-miR-4291 hsa-miR-300 hsa-miR-15a hsa-let-7a-2* hsa-miR-301a hsa-miR-507 hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDLL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLL1
    Predesigned siRNA for gene silencing in human, mouse, rat DLL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DLL1

    Clone
    Products:
         
    OriGene clones in human, mouse for DLL1 (see all 6)
    OriGene ORF clones in mouse, rat for DLL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLL1 (NM_005618)
    Sino Biological Human cDNA Clone for DLL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DLL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DLL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12092) for DLL1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DLL1_HUMAN, O00548: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11823422
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS10079256
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with DLL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DLL1 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Signaling by NOTCH30.00
    Notch Signaling Pathway0.84
    Signaling by NOTCH40.00
    Delta-Notch Signaling Pathway0.33
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    3Signaling by NOTCH2
    NOTCH2 Activation and Transmission of Signal to the Nucleus0.67
    Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1-M1580_K2555) Translocation Mutant0.00
    Signaling by NOTCH20.67
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.00
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Development Notch Signaling Pathway0.50
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with DLL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DLL1
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DLL1
        Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for DLL1
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for DLL1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway

    5 BioSystems Pathways for DLL1
        Notch Signaling Pathway
    Neural Crest Differentiation
    Delta-Notch Signaling Pathway
    Presenilin action in Notch and Wnt signaling
    Notch signaling pathway


    Selected Reactome Pathways for DLL1 (see all 8)
        NOTCH2 Activation and Transmission of Signal to the Nucleus
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Signaling by NOTCH4
    Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    Signaling by NOTCH3


    1 Kegg Pathway  (Kegg details for DLL1):
        Notch signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLL1 (see all 6): 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DLL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DLL1 (O005483 ENSP000003557184) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL9P329693, ENSP000003460224I2D: score=1 STRING: ENSP00000346022
    RPL9P7P329693I2D: score=1 
    RPL9P8P329693I2D: score=1 
    RPL9P9P329693I2D: score=1 
    NOTCH2Q047213, ENSP000002566464I2D: score=4 STRING: ENSP00000256646
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001709cell fate determination NAS11581320
    GO:0001756somitogenesis ----
    GO:0001757somite specification IEA--
    GO:0001947heart looping ISS--
    GO:0007154cell communication ----

    Find genes that share ontologies with DLL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DLL1 gene: 
    NM_005618.3  

    Unigene Cluster for DLL1:

    Delta-like 1 (Drosophila)
    Hs.379912  [show with all ESTs]
    Unigene Representative Sequence: NM_005618
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366756(uc003qxm.3 uc011ehc.1 uc003qxn.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DLL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLL1 (see all 58):
    hsa-miR-4291 hsa-miR-300 hsa-miR-15a hsa-let-7a-2* hsa-miR-301a hsa-miR-507 hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDLL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DLL1
    Predesigned siRNA for gene silencing in human, mouse, rat DLL1
    Clone
    Products:
         
    OriGene clones in human, mouse for DLL1 (see all 6)
    OriGene ORF clones in mouse, rat for DLL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLL1 (NM_005618)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DLL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLL1
      QuantiTect SYBR Green Assays in human, mouse, rat DLL1
      QuantiFast Probe-based Assays in human, mouse, rat DLL1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12092) for DLL1 

    Additional mRNA sequence: 

    AK311474.1 AK314234.1 AY358892.1 EU927387.1 

    9 DOTS entries:

    DT.95371420  DT.97799191  DT.452829  DT.97776883  DT.40286938  DT.91760856  DT.95371415  DT.65287575 
    DT.99933010 

    Selected AceView cDNA sequences (see all 70):

    BM692552 AI796243 AI245089 BU680220 AW118784 AI380366 BC028096 AI150995 
    AW274267 AI493673 BE465960 AY358892 BM544714 BM721695 AI361007 AI360108 
    CD516952 AI199592 AW131561 BI834106 AI423393 AA650523 AI360021 BF507416 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DLL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:              -                             -                                                   
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for DLL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DLL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATCTGTAA
    DLL1 Expression
    About this image


    DLL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Kidney (Urinary System)    fully expand to see all 8 entries
             Distal Renal Vesicle Cells Renal Vesicle
             S-shaped Body
     
     Neural Tube (Nervous System)    fully expand to see all 10 entries
             Metencephalon
             Floor plate-like cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Notochord Cells Notochord
     
     Limb (Muscoskeletal System)    fully expand to see all 7 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             Zeugopod
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             Paraxial Mesoderm Cells Paraxial Mesoderm
    DLL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.379912

    UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548
    Tissue specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no
    expression in placenta, lung, liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLL1 (see all 6): 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DLL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLL1
    QuantiTect SYBR Green Assays in human, mouse, rat DLL1
    QuantiFast Probe-based Assays in human, mouse, rat DLL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DLL1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dll11 , 5 delta-like 1 (Drosophila)1, 5 85.3(n)1
    88.77(a)1
      17 (8.95 cM)5
    133881  NM_007865.31  NP_031891.21 
     153673545 
    chicken
    (Gallus gallus)
    Aves DLL11 delta-like 1 (Drosophila) 81.96(n)
    84.94(a)
      395820  NM_204973.1  NP_990304.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLL16
    Delta-like protein
    67(a)
    1 ↔ 1
    1(223340447-223356751)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525612 similar to delta-like 1 (Drosophila) 74.17(n)    BC044262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dld2 deltaD 76.72(n)   30138  NM_130955.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dl1 , 3 antennal morphogenesis Notch binding3
    Delta1
    47(a)
    (best of 3)3
    57.12(n)1
    51.09(a)1
      423131  NM_001260264.21  NP_001247193.11 


    ENSEMBL Gene Tree for DLL1 (if available)
    TreeFam Gene Tree for DLL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DLL1 gene
    DLK22  SNED12  NOTCH42  NOTCH12  DLL32  NOTCH32  DLL42  JAG22  
    CRB22  DLK12  NOTCH22  JAG12  DNER2  CRB12  
    4 SIMAP similar genes for DLL1 using alignment to 2 protein entries:     DLL1_HUMAN (see all proteins):
    DLL4    JAG1    DLK1    JAG2

    Find genes that share paralogs with DLL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DLL1 (see all 366)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865019421,2
    --170617936(+) CCGACA/GGGAAG 1 -- ds50010--------
    rs1508775471,2
    C--170617969(+) CCCACA/GCCCCG 1 -- ds50010--------
    rs10284871,2
    C,A--170617973(-) CAGACT/GGGGCG 1 -- ds50016Minor allele frequency- G:0.37EA WA NA 540
    rs562159441,2
    C--170618062(+) AATGA-/ATG   
       AATGA
    GGAAC
    1 -- ds50010--------
    rs1409547621,2
    C--170618062(+) CTGAC-/ATGA  
            
    ATGAA
    1 -- ds50010--------
    rs1131196051,2
    C--170618099(+) TGAAT-/G/    
       GAATG
    GAGGA
    1 -- ds50011CSA 2
    rs1402378231,2
    --170618179(+) TCATGA/CGCGTG 1 -- ds50010--------
    rs15698401,2
    C,F,A,H--170618246(-) AGCCCG/CTTCCT 1 -- ds50016Minor allele frequency- C:0.44NA WA CSA 246
    rs1903198221,2
    --170618247(+) GGAACA/GGGCTG 1 -- ds50010--------
    rs1829253371,2
    --170618264(+) ATGGAC/TCCAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DLL1 (170591294 - 170599697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DLL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887030CNV Loss21882294
    nsv887028CNV Loss21882294
    dgv7054n71CNV Loss21882294
    nsv464226CNV Loss19166990
    nsv823936CNV Gain20364138
    nsv428158CNV Gain18775914
    nsv823937CNV Gain20364138
    esv344CNV CNV17122850
    dgv2040e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): DLL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLL1
    DNA2.0 Custom Variant and Variant Library Synthesis for DLL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606582    OMIM disorders: --

    9 diseases for DLL1:    
    About MalaCards
    superficial basal cell carcinoma    visceral leishmaniasis    nephroblastoma    septopreoptic holoprosencephaly
    midline interhemispheric variant of holoprosencephaly    alobar holoprosencephaly    single median maxillary central incisor    lobar holoprosencephaly
    semilobar holoprosencephaly

    2 diseases from the University of Copenhagen DISEASES database for DLL1:
    Heart disease     Vascular disease

    Find genes that share disorders with DLL1           About GenesLikeMe

    3 Novoseek inferred disease relationships for DLL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 30.8 3 15254769 (1), 12684674 (1), 16077982 (1)
    tumors 0 3 15919944 (2), 17922128 (1)
    lymphoma 0 1 16077982 (1)

    Genetic Association Database (GAD): DLL1
    Human Genome Epidemiology (HuGE) Navigator: DLL1 (2 documents)

    Export disorders for DLL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DLL1 gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with DLL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FGFR2 is associated with hair thickness in Asian populations. (PubMed id 19590514)1, 4 Fujimoto A....Ohashi J. (J. Hum. Genet. 2009)
    2. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4 Halaschek-Wiener J....Brooks-Wilson A.R. (PLoS ONE 2009)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. (PubMed id 11581320)1, 2 Jaleco A.C.... Parreira L. (J. Exp. Med. 2001)
    6. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. (PubMed id 10688816)1, 2 Han W.... Moore M.A.S. (Blood 2000)
    7. Human ligands of the Notch receptor. (PubMed id 10079256)1, 2 Gray G.E.... Artavanis-Tsakonas S. (Am. J. Pathol. 1999)
    8. MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. (PubMed id 15908431)1, 9 Mizuhara E....Takai Y. (J. Biol. Chem. 2005)
    9. Cellular analysis of growth suppression induced by the Notch ligands, Delta-1 and Jagged-1 in two myeloid leukemia cell lines. (PubMed id 15254769)1, 9 Murata-Ohsawa M....Nara N. (Int. J. Mol. Med. 2004)
    10. The Notch ligand, Delta-1, reduces TNF-alpha-induced growth suppression and apoptosis by decreasing activation of caspases in U937 cells. (PubMed id 15492857)1, 9 Murata-Ohsawa M....Nara N. (Int. J. Mol. Med. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 28514 HGNC: 2908 AceView: DLL1 Ensembl:ENSG00000198719 euGenes: HUgn28514
    ECgene: DLL1 Kegg: 28514 H-InvDB: DLL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DLL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DLL1 gene:
    Search GeneIP for patents involving DLL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for DLL1 (DLL1)   Browse Cell Culture Products  
     ELISAs for DLL1 (DLL1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for DLL1 (DLL1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DLL1   OriGene RNAi products in human, mouse, rat for DLL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DLL1  
     OriGene MassSpec something-or-other for DLL1   OriGene clones in human, mouse for DLL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DLL1   OriGene Purified Protein for DLL1  
     OriGene ORF clones in mouse, rat for DLL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DLL1   OriGene Custom Protein Services for DLL1  

     
     
     Block miRNA regulation of human, mouse, rat DLL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DLL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLL1 Predesigned siRNA for gene silencing in human, mouse, rat DLL1
     QuantiFast Probe-based Assays in human, mouse, rat DLL1 QuantiTect SYBR Green Assays in human, mouse, rat DLL1
     PCR Arrays including human, mouse, rat DLL1 Search Chromatin IP Primers for DLL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLL1  GeneGlobe Interaction Network for DLL1
     Regulatory tfbs in DLL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DLL1 GenScript cDNA clones with any tag delivered in your preferred vector for DLL1
     GenScript Custom Assay Services for DLL1 GenScript Custom overexpressing Cell Line Services for DLL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for DLL1 

     Search Tocris compounds for DLL1
     Proteins for DLL1
     Cell Lysates for DLL1
     cDNA Clones for DLL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for DLL1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DLL1 antibodies
     DLL1 proteins
     DLL1 lysates
     Search for Antibodies for DLL1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DLL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for DLL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL1
     SwitchGear 3'UTR luciferase reporter plasmids for DLL1
     SwitchGear Promoter luciferase reporter plasmids for DLL1
     ThermoFisher Antibodies for DLL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLL1
     LSBio Antibodies in human, mouse, rat for DLL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DLL1
      Search eBioscience for proteins for DLL1
      Search eBioscience for elisas for DLL1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DLL1 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4