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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DLL1 Gene

protein-coding GIFtS: 66
GCID: GC06M170591

delta-like 1 (Drosophila)

(Previous name: delta (Drosophila)-like 1 )

Explore 28 diseases affiliated with
DLL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Delta-Like 1 (Drosophila)¹ ²		DL1²
Drosophila Delta Homolog 1² ³		Delta²
H-Delta-1² ³		Delta-Like Protein 1²
Delta (Drosophila)-Like 1¹		Delta1³
DELTA1²

External Ids:	HGNC: 2908¹	Entrez Gene: 28514²	Ensembl: ENSG00000198719⁷	OMIM: 606582⁵	UniProtKB: O00548³

Export aliases for DLL1 gene to outside databases

Previous GC identifers: GC06M169786 GC06M170206 GC06M170447 GC06M170508 GC06M168099

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLL1:

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role

in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548

Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage

while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor

Gene Wiki entry for DLL1 (Delta-like 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DLL1 gene promoter:
NF-1/L Tal-1 FOXD3 E47 GATA-1 Evi-1 HOXA5 STAT3 NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLL1 promoter sequence

Search SABiosciences Chromatin IP Primers for DLL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q13-q22.33

DLL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLL1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M170591: view genomic region (about GC identifiers)

Start:	170,591,294 bp from pter	End:	170,599,697 bp from pter
Size:	8,404 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548 (See protein sequence)

Recommended Name: Delta-like protein 1 precursor

Size: 723 amino acids; 78056 Da

Subunit: Interacts with Notch receptors

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: B2RAK7 Q9NU41 Q9UJV2

Explore the universe of human proteins at neXtProt for DLL1: NX_O00548

Post-translational modifications:

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00548

DLL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005609.3

ENSEMBL proteins:

ENSP00000355718

Reactome Protein details: O00548
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: DLL1 OriGene Protein Over-expression Lysate: DLL1 OriGene Custom Protein Services for DLL1
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	Novus Biologicals DLL1 Protein Novus Biologicals DLL1 Lysate
	Sino Biological Recombinant Protein for DLL1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DLL1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	11823422
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	10079256
GO:0031410	cytoplasmic vesicle	IEA	--

DLL1 for ontologies About GeneDecksing

DLL1 Antibody Products:

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	GenScript Custom Superior Antibodies Services for DLL1
	Novus Biologicals DLL1 Antibodies
	Search for Antibodies for DLL1 at Abcam
	Uscn Antibodies for DLL1
	ThermoFisher Antibodies for DLL1

Assay Products for DLL1:

	Browse Kits and Assays available from EMD Millipore
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	Enzo Life Sciences assays for DLL1
	Uscn ELISAs and CLIAs for DLL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DLL1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR001881 EGF-like_Ca-bd

IPR001774 DSL

IPR000742 EG-like_dom

IPR013032 EGF-like_CS

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

Graphical View of Domain Structure for InterPro Entry O00548

ProtoNet protein and cluster: O00548

5 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001438 Type II EGF-like signature

IPB001774 Delta/Serrate/lag-2 (DSL) protein

IPB001881 EGF-like calcium-binding

IPB011651 Notch ligand

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548

Similarity: Contains 1 DSL domain

Similarity: Contains 8 EGF-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548

Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage

while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor

Summary:

During embryonic development, DLL1 as signaling molecule is secreted from the following cells: Paraxial Mesoderm Cells in Paraxial Mesoderm It affects the following cells: Muscle Progenitor Cells in Cervical Dorsomedial Dermomyotome Lip

miRNA Products:		miRTarBase miRNAs that target DLL1: hsa-mir-34a (MIRT001757)

		OriGene 3'-UTR Clone: DLL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLL1
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate DLL1 (see all 58):
		hsa-miR-4291 hsa-miR-300 hsa-miR-15a hsa-let-7a-2* hsa-miR-301a hsa-miR-507 hsa-miR-449a hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: DLL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLL1 (see all 7) OriGene shRNA RFP: DLL1 OriGene siRNA: DLL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DLL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLL1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DLL1 (NM_005618)
		Sino Biological Human cDNA Clone for DLL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DLL1
		Search LifeMap BioReagents cell lines for DLL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005112	Notch binding	IPI	11823422
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	10079256

DLL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DLL1:

Increased gamma-H2AX phosphory

Animal Models:
15/19 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Dll1) (see all 19):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	limbs/digits/tail	mortality/aging	muscle

DLL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

8/10 pathways (see all 10)
Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00	FBXW7 Mutants and NOTCH1 in Cancer	1.00
Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.79
Signaling by NOTCH1 in Cancer	1.00	Signaling by NOTCH	0.77

NOTCH2 Activation and Transmission of Signal to the Nucleus

NOTCH2 Activation and Transmission of Signal to the Nucleus	1.00	Activated NOTCH1 Transmits Signal to the Nucleus	0.58
Signaling by NOTCH2	1.00	Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor	0.43
Constitutive Signaling by NOTCH1 HD Domain Mutants	0.62	Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	0.24

Notch Signaling Pathway

	Notch Signaling Pathway	1.00			Delta-Notch Signaling Pathway	0.27
	Notch signaling pathway	0.82

Development_Notch Signaling Pathway

Development_Notch Signaling Pathway

1.00

Development Notch Signaling Pathway

0.97

Development NOTCH1-mediated pathway for NF-KB activity modulation

Development NOTCH1-mediated pathway for NF-KB activity modulation

1.00

Development_NOTCH1-mediated pathway for NF-KB activity modulation

0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DLL1

	Development Notch Signaling Pathway
	Development NOTCH1-mediated pathway for NF-KB activity modulation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DLL1

Epithelial Adherens Junctions

1 Cell Signaling Technology (CST) Pathway for DLL1

Wnt / Hedgehog / Notch

2 GeneGo (Thomson Reuters) Pathways for DLL1

	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Development Notch Signaling Pathway

5 BioSystems Pathways for DLL1

	Notch Signaling Pathway
	Neural Crest Differentiation
	Delta-Notch Signaling Pathway
	Notch signaling pathway
	Presenilin action in Notch and Wnt signaling

5/21 Reactome Pathways for DLL1 (see all 21)

	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	FBXW7 Mutants and NOTCH1 in Cancer
	Signaling by NOTCH1 HD Domain Mutants in Cancer
	Signaling by NOTCH1 in Cancer
	Disease

1 Kegg Pathway (Kegg details for DLL1):

Notch signaling pathway

DLL1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DLL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/83 Interacting proteins for DLL1 (O00548³ ENSP00000355718⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 83)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL9	P32969³, ENSP00000346022⁴	I2D: score=1 STRING: ENSP00000346022
RPL9P7	P32969³	I2D: score=1
RPL9P8	P32969³	I2D: score=1
RPL9P9	P32969³	I2D: score=1
NOTCH2	Q04721³, ENSP00000256646⁴	I2D: score=4 STRING: ENSP00000256646

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001709	cell fate determination	NAS	11581320
GO:0001756	somitogenesis	--	--
GO:0001757	somite specification	IEA	--
GO:0001947	heart looping	ISS	--
GO:0007219	Notch signaling pathway	TAS	--

DLL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DLL1
Search CenterWatch for drugs/clinical trials and news about DLL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DLL1 gene:

NM_005618.3

Unigene Cluster for DLL1:

Delta-like 1 (Drosophila)

Hs.379912 [show with all ESTs]

Unigene Representative Sequence: NM_005618

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000366756(uc003qxm.3 uc011ehc.1 uc003qxn.3)

miRNA Products:		OriGene 3'-UTR Clone: DLL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLL1
		8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate DLL1 (see all 58):
		hsa-miR-4291 hsa-miR-300 hsa-miR-15a hsa-let-7a-2* hsa-miR-301a hsa-miR-507 hsa-miR-449a hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: DLL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLL1 (see all 7) OriGene shRNA RFP: DLL1 OriGene siRNA: DLL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLL1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DLL1 (NM_005618)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLL1
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLL1

Additional cDNA sequence:

AK311474.1 AK314234.1 AY358892.1 EU927387.1

9 DOTS entries:

DT.95371420 DT.97799191 DT.452829 DT.97776883 DT.40286938 DT.91760856 DT.95371415 DT.65287575

DT.99933010

24/70 AceView cDNA sequences (see all 70):

BM692552 AI493673 BE465960 AW274267 AI199592 BM721695 BM544714 BU680220

AI245089 AI150995 BC028096 AI360021 AI380366 AA650523 AW118784 AI361007

BI834106 CD516952 AI360108 AW131561 AI796243 AI423393 BF507416 AY358892

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DLL1 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11
SP1:					-										-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for DLL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DLL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATCTGTAA

About this image

DLL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/77 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 77)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Distal Renal Vesicle Cells

Selective marker (cell-identifying gene)

Kidney

S-shaped Body Medial Segment

S-shaped Body Medial Cells

Kidney

Paraxial Mesoderm

Paraxial Mesoderm Cells

Mesoderm

Cartilage

Limb Muscle Progenitor Cells

Skeletal Muscle

Limb

Hindlimb Myotome

Limb Muscle Progenitor Cells

Skeletal Muscle

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Mesoderm precursors (Generation of skelet...)

N2/LSB induced-cells (Generation of midbra...)

Midbrain dopaminergic-like neurons (Generation of midbra...)

Posterior foregut-like cells (A scalable, suspensi...)

See DLL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DLL1

SOURCE GeneReport for Unigene cluster: Hs.379912

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548

Tissue specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression

in placenta, lung, liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including DLL1 (see all 6):

Neurogenesis in human mouse rat

Adherens Junctions in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Notch Signaling Pathway in human mouse rat

Stem Cells in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DLL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DLL1 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DLL1¹	delta-like 1 (Drosophila)	81.71(n) 84.58(a)		395820 NM_204973.1 NP_990304.1
lizard (Anolis carolinensis)	Reptilia	D3K9V7_ANOCA⁶	Distal-less Fragment	74(a)	1 ↔ 1	1(223354388-223354957)
African clawed frog (Xenopus laevis)	Amphibia	MGC52561²	similar to delta-like 1 (Drosophila)	74.17(n)		BC044262.1
zebrafish (Danio rerio)	Actinopterygii	dld²	deltaD	76.72(n)		30138 NM_130955.1
fruit fly (Drosophila melanogaster)	Insecta	Dl^{1 , 3}	antennal morphogenesis Notch binding³ Delta¹	47(a) (best of 3)³ 56.09(n)¹ 50.29(a)¹		42313¹ NM_057916.3¹ NP_477264.1¹
worm (Caenorhabditis elegans)	Secernentea	apx-1³	Expression: blastula embryo	32(a)		V(3210056-3222276) --

ENSEMBL Gene Tree for DLL1 (if available)
TreeFam Gene Tree for DLL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DLL1 gene

NOTCH4² SNED1² NOTCH1² NOTCH3² DLL3² DLL4² JAG2² CRB2²

NOTCH2² JAG1² DNER² CRB1²

4 SIMAP similar genes for DLL1 using alignment to 2 protein entries: DLL1_HUMAN (see all proteins):

DLL4 JAG1 DLK1 JAG2

DLL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56324374^1,2		--	168097975(+)	`GCCTCG/ACGGGC`	1	--	ds500¹		2		CSA WA	120
rs41269629^1,2		--	168098513(+)	`GTGCCG/ACAGGC`	1	--	ut3¹		1		NA	120
rs17860720^1,2		--	168098523(-)	`CGGCCC/TGGCCG`	1	--	ut3¹ ese³		0	--	--	--	--
rs1033582^1,2	C,F,H	--	168098927(-)	`AGCATC/TTGAAA`	2	S F	mis¹ ese³		12		NA EA MN NS	1446
rs111294306^1,2	F	--	168099093(+)	`TTCTCC/TTCCCC`	2	E	syn¹		2		CSA	6
rs2747761^1,2	C	--	168099608(-)	`GCCACC/G/TGCTAT`	3	R G C	mis¹ ese³		1		NA	2554
rs34540599^1,2	F	--	168099696(-)	`CCTGGC/GTACAC`	2	G	syn¹		1		NA	60
rs12214318^1,2	C,F	--	168099789(+)	`TTGTCG/ATCACA`	2	/D	syn¹ ese³		1		NA	3936
rs6935859^1,2	C,	--	168100092(+)	`CAGGCG/ACTGTG`	1	--	int¹		2		WA	120
rs17860714^1,2		--	168100124(-)	`GTGGCA/GACTAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DLL1 (170591294 - 170599697 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DLL1
1 CNV: 3657
Human Gene Mutation Database (HGMD): DLL1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DLL1 for disorders           About GeneDecksing

OMIM gene information: 606582    OMIM disorders: --

20/28 diseases for DLL1 (see all 28):    About MalaCards

hematopoiesis superficial basal cell carcinoma non-hodgkin lymphoma basal cell carcinoma

leukemia/lymphoma leukemia/lymphoma, t-cell infective endocarditis hodgkin's lymphoma

cadasil ganglioneuroblastoma endocarditis ganglioneuroma

nephroblastoma rheumatoid arthritis myeloid leukemia hypercholesterolemia

rabies hepatoblastoma purpura leukemia

2 diseases from the University of Copenhagen DISEASES database for DLL1:

dentatorubral-pallidoluysian atrophy Heart disease

3 Novoseek disease relationships for DLL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	30.8	3	15254769 (1), 12684674 (1), 16077982 (1)
tumors	0	3	15919944 (2), 17922128 (1)
lymphoma	0	1	16077982 (1)

Human Genome Epidemiology (HuGE) Navigator: DLL1 (2 documents)

Export disorders for DLL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DLL1 gene, integrated from 9 sources (see all 110):
(articles sorted by number of sources associating them with DLL1)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. (PubMed id 11581320)^{1, 2} Jaleco A.C.... Parreira L. (2001)
A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. (PubMed id 10688816)^{1, 2} Han W.... Moore M.A.S. (2000)
Human ligands of the Notch receptor. (PubMed id 10079256)^{1, 2} Gray G.E.... Artavanis-Tsakonas S. (1999)
MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. (PubMed id 15908431)^{1, 9} Mizuhara E....Takai Y. (2005)
Cellular analysis of growth suppression induced by the Notch ligands, Delta-1 and Jagged-1 in two myeloid leukemia cell lines. (PubMed id 15254769)^{1, 9} Murata-Ohsawa M....Nara N. (2004)
The Notch ligand, Delta-1, reduces TNF-alpha-induced growth suppression and apoptosis by decreasing activation of caspases in U937 cells. (PubMed id 15492857)^{1, 9} Murata-Ohsawa M....Nara N. (2004)
Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line. (PubMed id 19724883)^{1, 9} Qian C.F....You Y.P. (2009)
The intracellular domain of Notch ligand Delta1 induces cell growth arrest. (PubMed id 16225865)^{1, 9} Kolev V....Prudovsky I. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 28514	HGNC: 2908	AceView: DLL1	Ensembl:ENSG00000198719	euGenes: HUgn28514
ECgene: DLL1	Kegg: 28514	H-InvDB: DLL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DLL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DLL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DLL1 gene:
Search GeneIP for patents involving DLL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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