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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLL1 Gene

protein-coding   GIFtS: 66
GCID: GC06M170591

Delta-Like 1 (Drosophila)

(Previous name: delta (Drosophila)-like 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Delta-Like 1 (Drosophila)1 2     DL12
Drosophila Delta Homolog 12 3     Delta2
H-Delta-12 3     Delta-Like Protein 12
Delta (Drosophila)-Like 11     Delta13
DELTA12     

External Ids:    HGNC: 29081   Entrez Gene: 285142   Ensembl: ENSG000001987197   OMIM: 6065825   UniProtKB: O005483   

Export aliases for DLL1 gene to outside databases

Previous GC identifers: GC06M169786 GC06M170206 GC06M170447 GC06M170508 GC06M168099


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLL1 Gene:
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a
role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DLL1 Gene: 
DLL1 (delta-like 1 (Drosophila)) is a protein-coding gene. Diseases associated with DLL1 include superficial basal cell carcinoma, and infective endocarditis, and among its related super-pathways are Notch signaling pathway and Constitutive Signaling by NOTCH1 PEST Domain Mutants. GO annotations related to this gene include Notch binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548
Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell
lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell
precursor

Gene Wiki entry for DLL1 (Delta-like 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLL1 gene promoter:
         NF-1/L   Tal-1   FOXD3   E47   GATA-1   Evi-1   HOXA5   STAT3   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q13-q22.33

DLL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLL1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170591:  view genomic region     (about GC identifiers)

Start:
170,591,294 bp from pter      End:
170,599,697 bp from pter
Size:
8,404 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548 (See protein sequence)
Recommended Name: Delta-like protein 1 precursor  
Size: 723 amino acids; 78056 Da
Subunit: Interacts with Notch receptors
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B2RAK7 Q9NU41 Q9UJV2

Explore the universe of human proteins at neXtProt for DLL1: NX_O00548

Explore proteomics data for DLL1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00548

  • DLL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DLL1 Protein Expression
    REFSEQ proteins: NP_005609.3  
    ENSEMBL proteins: 
     ENSP00000355718  
    Reactome Protein details: O00548
    Human Recombinant Protein Products for DLL1: 
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    OriGene Protein Over-expression Lysate for DLL1
    OriGene MassSpec for DLL1 
    OriGene Custom Protein Services for DLL1
    GenScript Custom Purified and Recombinant Proteins Services for DLL1
    Novus Biologicals DLL1 Protein
    Novus Biologicals DLL1 Lysate
    Sino Biological Recombinant Protein for DLL1
    Sino Biological Cell Lysate for DLL1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11823422
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS10079256
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    DLL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR001774 DSL
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR011651 Notch_ligand_N

    Graphical View of Domain Structure for InterPro Entry O00548

    ProtoNet protein and cluster: O00548

    5 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001438 Type II EGF-like signature
    IPB001774 Delta/Serrate/lag-2 (DSL) protein
    IPB001881 EGF-like calcium-binding
    IPB011651 Notch ligand


    UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548
    Similarity: Contains 1 DSL domain
    Similarity: Contains 8 EGF-like domains


    DLL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLL1_HUMAN, O00548
    Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell
    lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell
    precursor

         Summary:

    During embryonic development, DLL1 as signaling molecule is secreted from the following cells: Paraxial Mesoderm Cells in Paraxial Mesoderm It affects the following cells: Muscle Progenitor Cells in Cervical Dorsomedial Dermomyotome Lip

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005112Notch binding IPI10079256
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10079256
         
    DLL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DLL1:
     Increased gamma-H2AX phosphory 

         15/20 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Dll1) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  muscle 

    DLL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DLL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DLL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLL1 
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate DLL1 (see all 58):
    hsa-miR-4291 hsa-miR-300 hsa-miR-15a hsa-let-7a-2* hsa-miR-301a hsa-miR-507 hsa-miR-449a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidDLL1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DLL1 About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    2Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    3Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
    Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor0.61
    Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.50
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.61
    4NOTCH2 intracellular domain regulates transcription
    Signaling by NOTCH20.66
    Activated NOTCH1 Transmits Signal to the Nucleus0.59
    NOTCH2 Activation and Transmission of Signal to the Nucleus0.66
    5Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Development Notch Signaling Pathway0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DLL1
        Development Notch Signaling Pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    1 R&D Systems Pathway for DLL1
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DLL1
        Epithelial Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for DLL1
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for DLL1
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway

    5 BioSystems Pathways for DLL1
        Notch Signaling Pathway
    Neural Crest Differentiation
    Delta-Notch Signaling Pathway
    Presenilin action in Notch and Wnt signaling
    Notch signaling pathway


    5/20        Reactome Pathways for DLL1 (see all 20)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    1         Kegg Pathway  (Kegg details for DLL1):
        Notch signaling pathway


    DLL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/84 Interacting proteins for DLL1 (O005483 ENSP000003557184) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL9P329693, ENSP000003460224I2D: score=1 STRING: ENSP00000346022
    RPL9P7P329693I2D: score=1 
    RPL9P8P329693I2D: score=1 
    RPL9P9P329693I2D: score=1 
    NOTCH2Q047213, ENSP000002566464I2D: score=4 STRING: ENSP00000256646
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001709cell fate determination NAS11581320
    GO:0001756somitogenesis ----
    GO:0001757somite specification IEA--
    GO:0001947heart looping ISS--
    GO:0007154cell communication ----

    DLL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLL1

    Search CenterWatch for drugs/clinical trials and news about DLL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DLL1 gene: 
    NM_005618.3  

    Unigene Cluster for DLL1:

    Delta-like 1 (Drosophila)
    Hs.379912  [show with all ESTs]
    Unigene Representative Sequence: NM_005618
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366756(uc003qxm.3 uc011ehc.1 uc003qxn.3)
    miRNA
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate DLL1 (see all 58):
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    Additional mRNA sequence: 

    AK311474.1 AK314234.1 AY358892.1 EU927387.1 

    9 DOTS entries:

    DT.95371420  DT.97799191  DT.452829  DT.97776883  DT.40286938  DT.91760856  DT.95371415  DT.65287575 
    DT.99933010 

    24/70 AceView cDNA sequences (see all 70):

    BU680220 AW118784 AY358892 AI150995 BM544714 BE465960 AI361007 AI360021 
    AW131561 AI423393 AW274267 AA650523 CD516952 BC028096 AI360108 BF507416 
    AI245089 AI380366 AI199592 BI834106 BM721695 BM692552 AI796243 AI493673 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DLL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:              -                             -                                                   
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for DLL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLL1 expression in normal human tissues (normalized intensities)      DLL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATCTGTAA
    DLL1 Expression
    About this image


    DLL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 43 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Somite (Muscoskeletal System)    fully expand to see all 34 entries
             Myoblasts Thoracic Primary Hypaxial Myotome
             mesenchyme/trunk mesenchyme/paraxial mesenchyme   
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Midbrain tegmentum
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 16 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             Stylopod
             limb/forelimb   
     
     Kidney (Urinary System)    fully expand to see all 10 entries
             Distal Renal Vesicle Cells Renal Vesicle
             Comma-shaped Body
             visceral organ/metanephros/calyx   

    See DLL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLL1

    SOURCE GeneReport for Unigene cluster: Hs.379912

    UniProtKB/Swiss-Prot: DLL1_HUMAN, O00548
    Tissue specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no
    expression in placenta, lung, liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including DLL1 (see all 6): 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Stem Cells in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DLL1 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dll11 , 5 delta-like 1 (Drosophila)1, 5 85.3(n)1
    88.77(a)1
      17 (8.95 cM)5
    133881  NM_007865.31  NP_031891.21 
     153673545 
    chicken
    (Gallus gallus)
    Aves DLL11 delta-like 1 (Drosophila) 81.71(n)
    84.58(a)
      395820  NM_204973.1  NP_990304.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLL16
    Dll1
    67(a)
    1 ↔ 1
    1(223340447-223356751)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525612 similar to delta-like 1 (Drosophila) 74.17(n)    BC044262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dld2 deltaD 76.72(n)   30138  NM_130955.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dl1 , 3 antennal morphogenesis Notch binding3
    Delta1
    47(a)
    (best of 3)3
    56.09(n)1
    50.29(a)1
      423131  NM_057916.31  NP_477264.11 


    ENSEMBL Gene Tree for DLL1 (if available)
    TreeFam Gene Tree for DLL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLL1 gene
    DLK22  SLIT22  SNED12  SLIT12  DLL32  JAG22  DLL42  DLK12  
    JAG12  DNER2  SLIT32  SVEP12  
    4 SIMAP similar genes for DLL1 using alignment to 2 protein entries:     DLL1_HUMAN (see all proteins):
    DLL4    JAG1    DLK1    JAG2

    DLL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/366 SNPs in DLL1 are shown (see all 366)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865019421,2
    --170617936(+) CCGACA/GGGAAG 1 -- ds50010--------
    rs1508775471,2
    C--170617969(+) CCCACA/GCCCCG 1 -- ds50010--------
    rs10284871,2
    C,A--170617973(-) CAGACT/GGGGCG 1 -- ds50016Minor allele frequency- G:0.37EA WA NA 540
    rs562159441,2
    C--170618062(+) AATGA-/ATG   
       AATGA
    GGAAC
    1 -- ds50010--------
    rs1409547621,2
    C--170618062(+) CTGAC-/ATGA  
            
    ATGAA
    1 -- ds50010--------
    rs1131196051,2
    C--170618099(+) TGAAT-/G/    
       GAATG
    GAGGA
    1 -- ds50011CSA 2
    rs1402378231,2
    --170618179(+) TCATGA/CGCGTG 1 -- ds50010--------
    rs15698401,2
    C,F,A,H--170618246(-) AGCCCG/CTTCCT 1 -- ds50016Minor allele frequency- C:0.44NA WA CSA 246
    rs1903198221,2
    --170618247(+) GGAACA/GGGCTG 1 -- ds50010--------
    rs1829253371,2
    --170618264(+) ATGGAC/TCCAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DLL1 (170591294 - 170599697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DLL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv887030CNV Loss21882294
    nsv887028CNV Loss21882294
    dgv7054n71CNV Loss21882294
    nsv464226CNV Loss19166990
    nsv823936CNV Gain20364138
    nsv428158CNV Gain18775914
    nsv823937CNV Gain20364138
    esv344CNV CNV17122850
    dgv2040e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): DLL1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DLL1
    DNA2.0 Custom Variant and Variant Library Synthesis for DLL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606582    OMIM disorders: --

    20/30 diseases for DLL1 (see all 30):    About MalaCards
    superficial basal cell carcinoma    infective endocarditis    nephroblastoma    endocarditis
    dentatorubral-pallidoluysian atrophy    cadasil    ganglioneuroblastoma    basal cell carcinoma
    ganglioneuroma    rabies    visceral leishmaniasis    purpura
    hepatoblastoma    hypercholesterolemia    hodgkin's lymphoma    non-hodgkin lymphoma
    leishmaniasis    astrocytoma    liver disease    type 1 diabetes

    2 diseases from the University of Copenhagen DISEASES database for DLL1:
    Heart disease     Vascular disease

    DLL1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for DLL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 30.8 3 15254769 (1), 12684674 (1), 16077982 (1)
    tumors 0 3 15919944 (2), 17922128 (1)
    lymphoma 0 1 16077982 (1)

    Genetic Association Database (GAD): DLL1
    Human Genome Epidemiology (HuGE) Navigator: DLL1 (2 documents)

    Export disorders for DLL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLL1 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with DLL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FGFR2 is associated with hair thickness in Asian popu lations. (PubMed id 19590514)1, 4 Fujimoto A....Ohashi J. (2009)
    2. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4 Halaschek-Wiener J....Brooks-Wilson A.R. (2009)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. (PubMed id 11581320)1, 2 Jaleco A.C.... Parreira L. (2001)
    6. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. (PubMed id 10688816)1, 2 Han W.... Moore M.A.S. (2000)
    7. Human ligands of the Notch receptor. (PubMed id 10079256)1, 2 Gray G.E.... Artavanis-Tsakonas S. (1999)
    8. MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. (PubMed id 15908431)1, 9 Mizuhara E....Takai Y. (2005)
    9. Cellular analysis of growth suppression induced by the Notch ligands, Delta-1 and Jagged-1 in two myeloid leukemia cell lines. (PubMed id 15254769)1, 9 Murata-Ohsawa M....Nara N. (2004)
    10. The Notch ligand, Delta-1, reduces TNF-alpha-induced growth suppression and apoptosis by decreasing activation of caspases in U937 cells. (PubMed id 15492857)1, 9 Murata-Ohsawa M....Nara N. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28514 HGNC: 2908 AceView: DLL1 Ensembl:ENSG00000198719 euGenes: HUgn28514
    ECgene: DLL1 Kegg: 28514 H-InvDB: DLL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DLL1 gene:
    Search GeneIP for patents involving DLL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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