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Aliases for DLL1 Gene

Aliases for DLL1 Gene

  • Delta-Like 1 (Drosophila) 2 3
  • Drosophila Delta Homolog 1 3 4
  • H-Delta-1 3 4
  • DELTA1 3 4
  • Delta (Drosophila)-Like 1 2
  • Delta-Like Protein 1 3
  • Delta 3
  • DL1 3

External Ids for DLL1 Gene

Summaries for DLL1 Gene

Entrez Gene Summary for DLL1 Gene

  • DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLL1 Gene

DLL1 (Delta-Like 1 (Drosophila)) is a Protein Coding gene. Diseases associated with DLL1 include superficial basal cell carcinoma and visceral leishmaniasis. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is NOTCH2.

UniProtKB/Swiss-Prot for DLL1 Gene

  • Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

Gene Wiki entry for DLL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLL1 Gene

Genomics for DLL1 Gene

Genomic Location for DLL1 Gene

Start:
170,282,200 bp from pter
End:
170,290,727 bp from pter
Size:
8,528 bases
Orientation:
Minus strand

Genomic View for DLL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLL1 Gene

Regulatory Elements for DLL1 Gene

Proteins for DLL1 Gene

  • Protein details for DLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00548-DLL1_HUMAN
    Recommended name:
    Delta-like protein 1
    Protein Accession:
    O00548
    Secondary Accessions:
    • B2RAK7
    • B5M0B3
    • Q9NU41
    • Q9UJV2

    Protein attributes for DLL1 Gene

    Size:
    723 amino acids
    Molecular mass:
    78056 Da
    Quaternary structure:
    • Interacts with Notch receptors

    Three dimensional structures from OCA and Proteopedia for DLL1 Gene

    Alternative splice isoforms for DLL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLL1 Gene

Proteomics data for DLL1 Gene at MOPED

Post-translational modifications for DLL1 Gene

  • Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn477

Other Protein References for DLL1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DLL1 Gene

Domains for DLL1 Gene

UniProtKB/Swiss-Prot:

DLL1_HUMAN
Domain:
  • Contains 1 DSL domain.:
    • O00548
  • Contains 8 EGF-like domains.:
    • O00548
genes like me logo Genes that share domains with DLL1: view

No data available for Gene Families for DLL1 Gene

Function for DLL1 Gene

Molecular function for DLL1 Gene

UniProtKB/Swiss-Prot Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

LifeMap Function Summary for DLL1 Gene

During embryonic development, DLL1 as signaling molecule is secreted from the following cells

Gene Ontology (GO) - Molecular Function for DLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 10079256
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10079256
genes like me logo Genes that share ontologies with DLL1: view
genes like me logo Genes that share phenotypes with DLL1: view

miRNA for DLL1 Gene

miRTarBase miRNAs that target DLL1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DLL1 Gene

Localization for DLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLL1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLL1 Gene COMPARTMENTS Subcellular localization image for DLL1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11823422
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10079256
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with DLL1: view

Pathways for DLL1 Gene

genes like me logo Genes that share pathways with DLL1: view

Gene Ontology (GO) - Biological Process for DLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001709 cell fate determination NAS 11581320
GO:0001756 somitogenesis --
GO:0001757 somite specification IEA --
GO:0001947 heart looping ISS --
GO:0007154 cell communication --
genes like me logo Genes that share ontologies with DLL1: view

Transcripts for DLL1 Gene

Unigene Clusters for DLL1 Gene

Delta-like 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for DLL1 Gene

GeneLoc Exon Structure for
DLL1
ECgene alternative splicing isoforms for
DLL1

Expression for DLL1 Gene

mRNA expression in normal human tissues for DLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLL1 Gene

This gene is overexpressed in Spleen (5.2).

SOURCE GeneReport for Unigene cluster for DLL1 Gene Hs.379912

mRNA Expression by UniProt/SwissProt for DLL1 Gene

O00548-DLL1_HUMAN
Tissue specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney
genes like me logo Genes that share expressions with DLL1: view

Orthologs for DLL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLL1 36
  • 99.49 (n)
  • 100 (a)
DLL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLL1 36
  • 87.75 (n)
  • 89.6 (a)
DLL1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLL1 36
  • 89.07 (n)
  • 90.92 (a)
DLL1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dll1 36
  • 85.3 (n)
  • 88.77 (a)
Dll1 16
Dll1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLL1 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLL1 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dll1 36
  • 85.2 (n)
  • 89.36 (a)
chicken
(Gallus gallus)
Aves DLL1 36
  • 81.96 (n)
  • 84.94 (a)
DLL1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLL1 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52561 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dll1 36
  • 72.98 (n)
  • 77.99 (a)
Str.15072 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3500 36
zebrafish
(Danio rerio)
Actinopterygii dla 37
  • 60 (a)
OneToMany
dlb 37
  • 53 (a)
OneToMany
dlc 37
  • 50 (a)
OneToMany
dld 36
  • 70.25 (n)
  • 72.31 (a)
dld 37
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010265 36
  • 53.97 (n)
  • 50.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dl 36
  • 57.12 (n)
  • 51.09 (a)
Dl 37
  • 35 (a)
OneToMany
Dl 38
  • 47 (a)
C901 38
  • 32 (a)
CG15388 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea apx-1 38
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
ManyToMany
CSA.7799 37
  • 34 (a)
ManyToMany
Species with no ortholog for DLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLL1 Gene

ENSEMBL:
Gene Tree for DLL1 (if available)
TreeFam:
Gene Tree for DLL1 (if available)

Paralogs for DLL1 Gene

Selected SIMAP similar genes for DLL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLL1: view

Variants for DLL1 Gene

Sequence variations from dbSNP and Humsavar for DLL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1028487 -- 170,281,792(-) CAGAC(G/T)GGGCG downstream-variant-500B
rs1033582 -- 170,283,094(-) AGCAT(C/T)TGAAA reference, missense
rs1033583 -- 170,282,835(-) TTAAA(A/C)TAAGT utr-variant-3-prime
rs1546949 -- 170,284,614(-) GGTGC(C/T)GGCCA intron-variant
rs1546950 -- 170,284,478(-) AAGGA(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLL1 Gene

Variant ID Type Subtype PubMed ID
nsv823936 CNV Gain 20364138
dgv7054n71 CNV Loss 21882294
nsv887028 CNV Loss 21882294
nsv887030 CNV Loss 21882294
nsv464226 CNV Loss 19166990
dgv2040e1 CNV Complex 17122850
esv344 CNV CNV 17122850
nsv428158 CNV Gain 18775914
nsv823937 CNV Gain 20364138

Relevant External Links for DLL1 Gene

HapMap Linkage Disequilibrium report
DLL1
Human Gene Mutation Database (HGMD)
DLL1

Disorders for DLL1 Gene

(2) University of Copenhagen DISEASES for DLL1 Gene

(3) Novoseek inferred disease relationships for DLL1 Gene

Disease -log(P) Hits PubMed IDs
leukemia 30.8 3
tumors 0 3
lymphoma 0 1

Relevant External Links for DLL1

Genetic Association Database (GAD)
DLL1
Human Genome Epidemiology (HuGE) Navigator
DLL1
genes like me logo Genes that share disorders with DLL1: view

No data available for UniProtKB/Swiss-Prot for DLL1 Gene

Publications for DLL1 Gene

  1. Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear. (PMID: 9858718) Lewis A.K. … Gao W.Q. (Mech. Dev. 1998) 3 23
  2. Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. (PMID: 11823422) Shimizu K. … Hirai H. (EMBO J. 2002) 3 23
  3. Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines. (PMID: 12684674) Tohda S. … Nara N. (Int. J. Oncol. 2003) 3 23
  4. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. (PMID: 10958687) Shimizu K. … Hirai H. (Mol. Cell. Biol. 2000) 3 23
  5. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. (PMID: 11006133) Shimizu K. … Hirai H. (Biochem. Biophys. Res. Commun. 2000) 3 23

Products for DLL1 Gene

Sources for DLL1 Gene

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