Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DLK2 Gene

protein-coding GIFtS: 46
GCID: GC06M043418

delta-like 2 homolog (Drosophila)

(Previous names: EGF-like-domain, multiple 9 )
(Previous symbol: EGFL9)

Search for DLK2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Delta-Like 2 Homolog (Drosophila)¹ ²		DLK-2² ³
EGFL9¹ ² ³		EGF-Like Protein 9² ³
EGF-Like-Domain, Multiple 9¹ ²		MGC2487¹
Epidermal Growth Factor-Like Protein 9² ³		Protein Delta Homolog 2²

External Ids:	HGNC: 21113¹	Entrez Gene: 65989²	Ensembl: ENSG00000171462⁷	UniProtKB: Q6UY11³

Export aliases for DLK2 gene to outside databases

Previous GC identifers: GC06M043528 GC06M043136

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DLK2_HUMAN, Q6UY11

Function: Regulates adipogenesis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DLK2 gene promoter:
HEN1 STAT3 RelA NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DLK2 promoter sequence

Search SABiosciences Chromatin IP Primers for DLK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

DLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLK2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M043418: view genomic region (about GC identifiers)

Start:	43,418,090 bp from pter	End:	43,424,370 bp from pter
Size:	6,281 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DLK2_HUMAN, Q6UY11 (See protein sequence)

Recommended Name: Protein delta homolog 2 precursor

Size: 383 amino acids; 40548 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: B3KNZ7 Q5T3T8 Q9BQ54

Alternative splicing: 2 isoforms: Q6UY11-1 Q6UY11-2 (Splicing acceptor site not canonical. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLK2: NX_Q6UY11

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UY11

DLK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_076421.2 NP_996262.1

ENSEMBL proteins:

ENSP00000399829 ENSP00000361563 ENSP00000361566 ENSP00000361574 ENSP00000349893

ENSP00000398906

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for DLK2
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): DLK2 OriGene Custom Protein Services for DLK2
	GenScript Custom Purified and Recombinant Proteins Services for DLK2
	Novus Biologicals DLK2 Protein Novus Biologicals DLK2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DLK2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

DLK2 for ontologies About GeneDecksing

DLK2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DLK2
	GenScript Custom Superior Antibodies Services for DLK2
	Novus Biologicals DLK2 Antibody
	Search for Antibodies for DLK2 at Abcam
	Uscn Antibodies for DLK2
	Search ThermoFisher Antibodies for DLK2

Assay Products for DLK2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DLK2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DLK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DLK2 for domains About GeneDecksing

5 InterPro domains/families:

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR013032 EGF-like_CS

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

IPR018097 EGF_Ca-bd_CS

Graphical View of Domain Structure for InterPro Entry Q6UY11

ProtoNet protein and cluster: Q6UY11

2 Blocks protein families:

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001881 EGF-like calcium-binding

UniProtKB/Swiss-Prot: DLK2_HUMAN, Q6UY11

Similarity: Contains 6 EGF-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DLK2_HUMAN, Q6UY11

Function: Regulates adipogenesis (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLK2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate DLK2:
		hsa-miR-3161 hsa-miR-3163 hsa-miR-4316 hsa-miR-485-5p hsa-miR-223*
		SwitchGear 3'UTR luciferase reporter plasmid: DLK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLK2 (see all 7) OriGene shRNA RFP: DLK2 OriGene siRNA: DLK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLK2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DLK2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLK2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLK2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DLK2 (NM_206539)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DLK2
		Search LifeMap BioReagents cell lines for DLK2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0042803	protein homodimerization activity	IEA	--
GO:0046982	protein heterodimerization activity	IEA	--

DLK2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DLK2:

Metaphase cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DLK2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for DLK2 (Q6UY11³ ENSP00000349893⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADAMTSL4	Q6UY14³, ENSP00000271643⁴	I2D: score=4 STRING: ENSP00000271643
KRTAP4-12	Q9BQ66³, ENSP00000377582⁴	I2D: score=4 STRING: ENSP00000377582
PLSCR1	O15162³, ENSP00000345494⁴	I2D: score=4 STRING: ENSP00000345494

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045598	regulation of fat cell differentiation	IEA	--
GO:0045746	negative regulation of Notch signaling pathway	IEA	--

DLK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DLK2
Search CenterWatch for drugs/clinical trials and news about DLK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DLK2 gene (2 alternative transcripts):

NM_023932.2 NM_206539.1

Unigene Cluster for DLK2:

Delta-like 2 homolog (Drosophila)

Hs.337251 [show with all ESTs]

Unigene Representative Sequence: AK055380

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000430324 ENST00000372485 ENST00000372488(uc003ova.3) ENST00000372496

ENST00000357338(uc003ovb.3) ENST00000414245

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLK2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate DLK2:
		hsa-miR-3161 hsa-miR-3163 hsa-miR-4316 hsa-miR-485-5p hsa-miR-223*
		SwitchGear 3'UTR luciferase reporter plasmid: DLK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLK2 (see all 7) OriGene shRNA RFP: DLK2 OriGene siRNA: DLK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLK2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLK2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLK2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DLK2 (NM_206539)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DLK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLK2

Additional cDNA sequence:

AK055380.1 AY358126.1 BC000230.1 BC006425.1 BC110320.1

8 DOTS entries:

DT.411217 DT.100785771 DT.121405383 DT.205330 DT.91741728 DT.121405555 DT.121405624 DT.91741730

24/35 AceView cDNA sequences (see all 35):

BM811564 CR605295 BC000230 BI916137 BF036368 BC006425 NM_206539 AK055380

BM473972 BE253630 BE790917 NM_023932 AI821058 AY358126 AI821110 BG818601

CA489352 AA651619 AI821806 BX360604 BX383794 BG830502 BX383793 BG818148

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DLK2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c
SP1:			-		-		-		-				-
SP2:									-				-
SP3:									-				-								-
SP4:									-
SP5:																							-

ECgene alternative splicing isoforms for DLK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DLK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCAGCAG

About this image

DLK2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Trachea

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DLK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DLK2

SOURCE GeneReport for Unigene cluster: Hs.337251

SABiosciences Custom PCR Arrays for DLK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DLK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLK2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DLK2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DLK2¹	delta-like 2 homolog (Drosophila)	65.85(n) 64.77(a)		428576 XM_426133.3 XP_426133.3
lizard (Anolis carolinensis)	Reptilia	DLK2⁶ NOTCH4⁶ (see all 3)	--	58(a) 4(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	1(231214139-231220461) 2(198817538-198859587)
zebrafish (Danio rerio)	Actinopterygii	LOC100150992¹	delta-like protein 1-like	58.28(n) 55.52(a)		100150992 XM_001921677.1 XP_001921712.1
fruit fly (Drosophila melanogaster)	Insecta	crb⁶ uif⁶	uninflatable	4(a) 2(a)	possible ortholog possible ortholog	3R(20120800-20140154) 2L(6972828-7010312)
worm (Caenorhabditis elegans)	Secernentea	glp-1⁶ lin-12⁶ (see all 3)	Protein lin-12 (see all 3)	6(a) 5(a) (see all 3)	possible ortholog possible ortholog (see all 3)	III(9092164-9099606) III(9060165-9071683)

ENSEMBL Gene Tree for DLK2 (if available)
TreeFam Gene Tree for DLK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DLK2 gene

DLK1² ENSG00000255168² NOTCH2NL²

12 SIMAP similar genes for DLK2 using alignment to 4 protein entries: DLK2_HUMAN (see all proteins):

JAG1 F9 NOTCH3 DLK1 NOTCH1 SVEP1

CRB1 NOTCH2 NOTCH2NL FAT4 ODZ1 TENM1

DLK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7752305^1,2	C,F,	--	43417852(+)	`GCAGAG/CTTCTC`	4	--	ut3¹ int¹		6		WA CSA EU	1985
rs6919343^1,2	C,F,A,H,	--	43418015(+)	`GGCTTC/TCCCAG`	4	--	ut3¹ int¹		7		NS WA	1520
rs190322173^1,2		--	43418232(+)	`TCTGAA/GGGGTG`	4	--	ds500¹ ut3¹		0	--	--	--	--
rs201223220^1,2		--	43418317(+)	`AGTCAC/TGTGGC`	6	H R	ds500¹ mis¹		0	--	--	--	--
rs35056042^1,2	C,F,	--	43418328(+)	`AGGGGG/AAGCCC`	6	/L	ds500¹ syn¹		5		NA EU	5075
rs150344664^1,2	F	--	43418329(+)	`GGGGGA/TGCCCT`	6	H L	ds500¹ mis¹		1		NA	3762
rs149448438^1,2	C	--	43418338(+)	`CTGCTG/TGCAGC`	6	Q P	ds500¹ mis¹		2		NA	4432
rs200290716^1,2		--	43418412(+)	`GGTCCA/GGGGGG`	6	P	ds500¹ syn¹		0	--	--	--	--
rs147136107^1,2	C,F,	--	43418428(+)	`CACCCC/TGGCGC`	6	Q R	ds500¹ mis¹		1		--	538
rs41281806^1,2	C,F,	--	43418453(+)	`CAGCAA/TCACAG`	6	M L	ds500¹ mis¹		2		NA EU	5157

HapMap Linkage Disequilibrium report for DLK2 (43418090 - 43424370 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DLK2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLK2

DNA2.0 Custom Variant and Variant Library Synthesis for DLK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DLK2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DLK2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis. (PubMed id 17320102)¹ Nueda M.L....Laborda J. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 65989	HGNC: 21113	AceView: EGFL9	Ensembl:ENSG00000171462	euGenes: HUgn65989
ECgene: DLK2	H-InvDB: DLK2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DLK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DLK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DLK2 gene:
Search GeneIP for patents involving DLK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for DLK2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLK2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLK2
	OriGene Protein Over-expression Lysate for DLK2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DLK2		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLK2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLK2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DLK2		OriGene Custom Protein Services for DLK2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DLK2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLK2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLK2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLK2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLK2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLK2

	GenScript Custom Purified and Recombinant Proteins Services for DLK2		GenScript cDNA clones with any tag delivered in your preferred vector for DLK2
	GenScript Custom Assay Services for DLK2		GenScript Custom Superior Antibodies Services for DLK2
	GenScript Custom overexpressing Cell Line Services for DLK2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DLK2 promoter
	Search Chromatin IP Primers for DLK2
	RT² qPCR Primer Assay in human, mouse, rat DLK2
	Search GNC Networks for DLK2
	SABiosciences Custom PCR Arrays for DLK2

Search Tocris compounds for DLK2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for DLK2
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DLK2 antibodies
	DLK2 proteins
	DLK2 lysates

	Search for Antibodies for DLK2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for DLK2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

DLK2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DLK2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK2

	SwitchGear 3'UTR luciferase reporter plasmids for DLK2
	SwitchGear Promoter luciferase reporter plasmids for DLK2

Search ThermoFisher Antibodies for DLK2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DLK2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

DLK2 Gene

delta-like 2 homolog (Drosophila)

Aliases
for DLK2 gene

Summaries
for DLK2 gene

Genomic Views
for DLK2 gene

Proteins
for DLK2 gene

Protein Domains /
Families
for DLK2 gene

Function
for DLK2 gene

Pathways & Interactions
for DLK2 gene

Drugs & Compounds
for DLK2 gene

Transcripts
for DLK2 gene

Expression
for DLK2 gene

Orthologs
for DLK2 gene

Paralogs
for DLK2 gene

Genomic Variants
for DLK2 gene

Disorders / Diseases
for DLK2 gene

Publications
for DLK2 gene

External Searches for DLK2 gene

Genome Databases showing DLK2 gene

Other Databases showing DLK2 gene

Specialized Databases showing DLK2 gene

Intellectual Property
for DLK2 gene

Products
for DLK2 gene

View Random Gene

Advanced Search

Export list of displayed genes

DLK2 Gene

delta-like 2 homolog (Drosophila)

Aliasesfor DLK2 gene

Summariesfor DLK2 gene

Genomic Viewsfor DLK2 gene

Proteinsfor DLK2 gene

Protein Domains /Familiesfor DLK2 gene

Functionfor DLK2 gene

Pathways & Interactionsfor DLK2 gene

Drugs & Compoundsfor DLK2 gene

Transcriptsfor DLK2 gene

Expression for DLK2 gene

Orthologsfor DLK2 gene

Paralogsfor DLK2 gene

Genomic Variantsfor DLK2 gene

Disorders / Diseasesfor DLK2 gene

Publicationsfor DLK2 gene

External Searches for DLK2 gene

Genome Databases showing DLK2 gene

Other Databases showing DLK2 gene

Specialized Databases showing DLK2 gene

Intellectual Propertyfor DLK2 gene

Productsfor DLK2 gene

View Random Gene

Aliases
for DLK2 gene

Summaries
for DLK2 gene

Genomic Views
for DLK2 gene

Proteins
for DLK2 gene

Protein Domains /
Families
for DLK2 gene

Function
for DLK2 gene

Pathways & Interactions
for DLK2 gene

Drugs & Compounds
for DLK2 gene

Transcripts
for DLK2 gene

Expression
for DLK2 gene

Orthologs
for DLK2 gene

Paralogs
for DLK2 gene

Genomic Variants
for DLK2 gene

Disorders / Diseases
for DLK2 gene

Publications
for DLK2 gene

Intellectual Property
for DLK2 gene

Products
for DLK2 gene