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Aliases for DLK2 Gene

Aliases for DLK2 Gene

  • Delta Like Non-Canonical Notch Ligand 2 2 3 5
  • Epidermal Growth Factor-Like Protein 9 3 4
  • EGF-Like-Domain, Multiple 9 2 3
  • EGF-Like Protein 9 3 4
  • EGFL9 3 4
  • DLK-2 3 4
  • Delta-Like 2 Homolog (Drosophila) 2
  • Protein Delta Homolog 2 3
  • Delta-Like 2 Homolog 3

External Ids for DLK2 Gene

Previous HGNC Symbols for DLK2 Gene

  • EGFL9

Previous GeneCards Identifiers for DLK2 Gene

  • GC06M043528
  • GC06M043136

Summaries for DLK2 Gene

GeneCards Summary for DLK2 Gene

DLK2 (Delta Like Non-Canonical Notch Ligand 2) is a Protein Coding gene. Among its related pathways are P38 MAPK Signaling Pathway (sino) and Canonical and Non-canonical Notch signaling. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is DLK1.

UniProtKB/Swiss-Prot for DLK2 Gene

  • Regulates adipogenesis.

Additional gene information for DLK2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLK2 Gene

Genomics for DLK2 Gene

Regulatory Elements for DLK2 Gene

Enhancers for DLK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H043390 1.5 Ensembl ENCODE dbSUPER 11.2 +64.2 64180 3.5 HDGF PKNOX1 ARNT TCF12 ZNF766 GATA2 ZNF592 SMARCA4 GLIS1 PBX2 ABCC10 RPL12P47 CRIP3 DLK2 TTBK1 DNPH1 POLR1C YIPF3 LRRC73 ZNF318
GH06H043382 1.4 Ensembl ENCODE dbSUPER 11.1 +72.8 72774 2.7 PKNOX1 TBL1XR1 BMI1 YBX1 BATF YY1 FOS ATF7 ETV6 RUNX3 SLC22A7 ABCC10 RPL12P47 CRIP3 DLK2 TTBK1 DNPH1 TJAP1 RNU6-1113P LRRC73
GH06H043261 1.3 FANTOM5 ENCODE dbSUPER 11.1 +194.3 194267 1.4 ELF3 SAP130 CEBPG RAD21 ZIC2 ZNF644 ZSCAN9 RARA TEAD3 GLIS2 DNPH1 SLC22A7 ZNF318 RPL12P47 CRIP3 DLK2 ENSG00000245261 CUL9 YIPF3 LRRC73
GH06H042928 1.4 ENCODE dbSUPER 9.2 +525.8 525844 5.6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF610 PEX6 ZNF318 POLH XPO5 RRP36 CUL7 GTPBP2 ABCC10 PPP2R5D RPS2P29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DLK2 on UCSC Golden Path with GeneCards custom track

Promoters for DLK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197132 1432 1201 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B SLC30A9 ZNF416 ZNF143 DEK MXD4

Genomic Locations for DLK2 Gene

Genomic Locations for DLK2 Gene
6,281 bases
Minus strand

Genomic View for DLK2 Gene

Genes around DLK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLK2 Gene

Proteins for DLK2 Gene

  • Protein details for DLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein delta homolog 2
    Protein Accession:
    Secondary Accessions:
    • B3KNZ7
    • Q5T3T8
    • Q9BQ54

    Protein attributes for DLK2 Gene

    383 amino acids
    Molecular mass:
    40548 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLK2 Gene


neXtProt entry for DLK2 Gene

Post-translational modifications for DLK2 Gene

  • Glycosylation at isoforms=157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DLK2 Gene

Domains & Families for DLK2 Gene

Gene Families for DLK2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DLK2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLK2: view

No data available for UniProtKB/Swiss-Prot for DLK2 Gene

Function for DLK2 Gene

Molecular function for DLK2 Gene

UniProtKB/Swiss-Prot Function:
Regulates adipogenesis.

Phenotypes From GWAS Catalog for DLK2 Gene

Gene Ontology (GO) - Molecular Function for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with DLK2: view
genes like me logo Genes that share phenotypes with DLK2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DLK2 Gene

Localization for DLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLK2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DLK2: view

Pathways & Interactions for DLK2 Gene

genes like me logo Genes that share pathways with DLK2: view

Pathways by source for DLK2 Gene

1 Sino Biological pathway for DLK2 Gene
1 BioSystems pathway for DLK2 Gene

Interacting Proteins for DLK2 Gene

SIGNOR curated interactions for DLK2 Gene


Gene Ontology (GO) - Biological Process for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045598 regulation of fat cell differentiation IEA --
GO:0045746 negative regulation of Notch signaling pathway IDA 25093684
genes like me logo Genes that share ontologies with DLK2: view

Drugs & Compounds for DLK2 Gene

No Compound Related Data Available

Transcripts for DLK2 Gene

Unigene Clusters for DLK2 Gene

Delta-like 2 homolog (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for DLK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLK2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of DLK2 Gene:


SOURCE GeneReport for Unigene cluster for DLK2 Gene:


Evidence on tissue expression from TISSUES for DLK2 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with DLK2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLK2 Gene

Orthologs for DLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DLK2 33 34
  • 99.56 (n)
(Canis familiaris)
Mammalia DLK2 33 34
  • 89.38 (n)
(Mus musculus)
Mammalia Dlk2 33 16 34
  • 89.18 (n)
(Rattus norvegicus)
Mammalia Dlk2 33
  • 89.18 (n)
(Bos Taurus)
Mammalia DLK2 33 34
  • 88.95 (n)
(Monodelphis domestica)
Mammalia DLK2 34
  • 57 (a)
(Gallus gallus)
Aves DLK2 33 34
  • 66.03 (n)
(Anolis carolinensis)
Reptilia DLK2 34
  • 57 (a)
(Danio rerio)
Actinopterygii dlk2 33 34
  • 58.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta wry 34
  • 7 (a)
Species where no ortholog for DLK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLK2 Gene

Gene Tree for DLK2 (if available)
Gene Tree for DLK2 (if available)

Paralogs for DLK2 Gene

Paralogs for DLK2 Gene

(7) SIMAP similar genes for DLK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLK2: view

Variants for DLK2 Gene

Sequence variations from dbSNP and Humsavar for DLK2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000752713 -- 43,454,561(+) TTCCA(C/G)TAACT intron-variant, upstream-variant-2KB
rs1000838366 -- 43,454,578(+) ACTCA(A/G)CCCTA intron-variant, upstream-variant-2KB
rs1000908391 -- 43,454,252(+) GAAGC(A/G)AGAGA intron-variant, upstream-variant-2KB
rs1001140674 -- 43,457,943(+) TTGAC(-/CAT)CTCCC upstream-variant-2KB
rs1001274998 -- 43,457,673(+) CCCCT(-/A)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DLK2 Gene

Variant ID Type Subtype PubMed ID
nsv950172 CNV deletion 24416366
nsv603000 CNV loss 21841781
nsv1144143 CNV deletion 24896259
nsv1074396 CNV deletion 25765185

Variation tolerance for DLK2 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLK2 Gene

Disorders for DLK2 Gene

Relevant External Links for DLK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DLK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLK2 Gene

Publications for DLK2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for DLK2 Gene

Sources for DLK2 Gene

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