Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DLK2 Gene

protein-coding   GIFtS: 50
GCID: GC06M043418

Delta-Like 2 Homolog (Drosophila)

(Previous names: EGF-like-domain, multiple 9)
(Previous symbol: EGFL9)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Delta-Like 2 Homolog (Drosophila)1 2     DLK-22 3
EGFL91 2 3     EGF-Like Protein 92 3
EGF-Like-Domain, Multiple 91 2     Protein Delta Homolog 22
Epidermal Growth Factor-Like Protein 92 3     

External Ids:    HGNC: 211131   Entrez Gene: 659892   Ensembl: ENSG000001714627   UniProtKB: Q6UY113   

Export aliases for DLK2 gene to outside databases

Previous GC identifers: GC06M043528 GC06M043136


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DLK2 Gene:
DLK2 (delta-like 2 homolog (Drosophila)) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and calcium ion binding. An important paralog of this gene is SNED1.

UniProtKB/Swiss-Prot: DLK2_HUMAN, Q6UY11
Function: Regulates adipogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLK2 gene promoter:
         HEN1   STAT3   RelA   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DLK2 promoter sequence
   Search Chromatin IP Primers for DLK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

DLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLK2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M043418:  view genomic region     (about GC identifiers)

Start:
43,418,090 bp from pter      End:
43,424,370 bp from pter
Size:
6,281 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DLK2_HUMAN, Q6UY11 (See protein sequence)
Recommended Name: Protein delta homolog 2 precursor  
Size: 383 amino acids; 40548 Da
Secondary accessions: B3KNZ7 Q5T3T8 Q9BQ54
Alternative splicing: 2 isoforms:  Q6UY11-1   Q6UY11-2   (Splicing acceptor site not canonical. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLK2: NX_Q6UY11

Explore proteomics data for DLK2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn157
  • Modification sites at PhosphoSitePlus

  • See DLK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273584.1  NP_001273585.1  NP_076421.2  NP_996262.1  

    ENSEMBL proteins: 
     ENSP00000399829   ENSP00000361563   ENSP00000361566   ENSP00000349893   ENSP00000398906  

    DLK2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for DLK2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DLK2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DLK2
    GenScript Custom Purified and Recombinant Proteins Services for DLK2
    Novus Biologicals DLK2 Protein
    Novus Biologicals DLK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DLK2 

    DLK2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DLK2
    Novus Biologicals DLK2 Antibodies
    Abcam antibodies for DLK2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for DLK2
    LSBio Antibodies in human, mouse, rat for DLK2

    DLK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DLK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DLK2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DLK2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR001881 EGF-like_Ca-bd_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q6UY11

    ProtoNet protein and cluster: Q6UY11

    2 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: DLK2_HUMAN, Q6UY11
    Similarity: Contains 6 EGF-like domains


    Find genes that share domains with DLK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLK2_HUMAN, Q6UY11
    Function: Regulates adipogenesis (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with DLK2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DLK2:
     Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLK2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DLK2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DLK2:
    hsa-miR-3161 hsa-miR-3163 hsa-miR-4316 hsa-miR-485-5p hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidDLK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLK2
    Predesigned siRNA for gene silencing in human, mouse, rat DLK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DLK2

    Clone
    Products:
         
    OriGene clones in human, mouse for DLK2 (see all 10)
    OriGene ORF clones in mouse, rat for DLK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DLK2 (NM_206539)
    Sino Biological Human cDNA Clone for DLK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DLK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DLK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DLK2_HUMAN, Q6UY11: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DLK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DLK2
    Interactions:

        Search GeneGlobe Interaction Network for DLK2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DLK2 (Q6UY113 ENSP000003498934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAMTSL4Q6UY143, ENSP000002716434I2D: score=4 STRING: ENSP00000271643
    KRTAP4-12Q9BQ663, ENSP000003775824I2D: score=4 STRING: ENSP00000377582
    PLSCR1O151623, ENSP000003454944I2D: score=4 STRING: ENSP00000345494
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045598regulation of fat cell differentiation IEA--
    GO:0045746negative regulation of Notch signaling pathway IEA--

    Find genes that share ontologies with DLK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLK2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DLK2 gene (4 alternative transcripts): 
    NM_001286655.1  NM_001286656.1  NM_023932.3  NM_206539.2  

    Unigene Cluster for DLK2:

    Delta-like 2 homolog (Drosophila)
    Hs.337251  [show with all ESTs]
    Unigene Representative Sequence: AK055380
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430324 ENST00000372485 ENST00000372488(uc003ova.3) ENST00000357338(uc003ovb.3)
    ENST00000414245
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DLK2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DLK2:
    hsa-miR-3161 hsa-miR-3163 hsa-miR-4316 hsa-miR-485-5p hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidDLK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DLK2
    Predesigned siRNA for gene silencing in human, mouse, rat DLK2
    Clone
    Products:
         
    OriGene clones in human, mouse for DLK2 (see all 10)
    OriGene ORF clones in mouse, rat for DLK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DLK2 (NM_206539)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DLK2
    OriGene qSTAR qPCR primer pairs in human, mouse for DLK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLK2
      QuantiTect SYBR Green Assays in human, mouse, rat DLK2
      QuantiFast Probe-based Assays in human, mouse, rat DLK2

    Additional mRNA sequence: 

    AK055380.1 AY358126.1 BC000230.1 BC006425.1 BC110320.1 

    8 DOTS entries:

    DT.411217  DT.100785771  DT.121405383  DT.205330  DT.91741728  DT.121405555  DT.121405624  DT.91741730 

    Selected AceView cDNA sequences (see all 35):

    NM_023932 AK055380 BM811564 NM_206539 BC006425 BF036368 BI916137 BC000230 
    CR605295 BE790917 BE253630 BM473972 BX360604 AA651619 AI821110 AI821806 
    BG830502 BG818601 BX383793 CA489352 AI821058 AY358126 BX383794 AW072286 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DLK2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:        -     -     -     -           -                                                         
    SP2:                          -           -                                                         
    SP3:                          -           -                       -                                 
    SP4:                          -                                                                     
    SP5:                                                                    -                           


    ECgene alternative splicing isoforms for DLK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DLK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCAGCAG
    DLK2 Expression
    About this image


    DLK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Lung (Respiratory System)
             Basal Cells Trachea
    DLK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.337251
        Custom PCR Arrays for DLK2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DLK2
    OriGene qSTAR qPCR primer pairs in human, mouse for DLK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLK2
    QuantiTect SYBR Green Assays in human, mouse, rat DLK2
    QuantiFast Probe-based Assays in human, mouse, rat DLK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DLK2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlk21 , 5 delta-like 2 homolog (Drosophila)1, 5 89.18(n)1
    92.41(a)1
      17 (22.90 cM)5
    1065651  NM_001286013.11  NP_001272942.11 
     462974215 
    chicken
    (Gallus gallus)
    Aves DLK21 delta-like 2 homolog (Drosophila) 66.03(n)
    65.31(a)
      428576  XM_004935408.1  XP_004935465.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLK26
    delta-like 2 homolog (Drosophila)
    57(a)
    1 ↔ 1
    1(231184936-231220461)
    zebrafish
    (Danio rerio)
    Actinopterygii dlk21 delta-like 2 homolog (Drosophila) 58.1(n)
    55.42(a)
      100150992  XM_001921677.2  XP_001921712.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta wry6
    weary
    7(a)
    1 → many
    2L(1836630-1858550)


    ENSEMBL Gene Tree for DLK2 (if available)
    TreeFam Gene Tree for DLK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DLK2 gene
    SNED12  NOTCH42  NOTCH12  DLL32  NOTCH32  DLL42  JAG22  CRB22  
    DLK12  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    7 SIMAP similar genes for DLK2 using alignment to 4 protein entries:     DLK2_HUMAN (see all proteins):
    JAG1    F9    DLK1    NOTCH1    SVEP1    CRB1
    NOTCH3

    Find genes that share paralogs with DLK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DLK2 (see all 159)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12147481,2
    C,F,A,H--43418691(+) TCACAA/GGTCTT 4 T syn1 ese335Minor allele frequency- T:0.00MN NA NS EA WA CSA EU 8818
    rs357892851,2
    C,F--43418710(+) AGCCAC/TTGGGG 4 N S mis13Minor allele frequency- T:0.01NA WA 4608
    rs801876361,2
    C--43418725(+) GGCAGG/TCGAAG 4 D A mis10--------
    rs352831341,2
    C--43418732(+) GAAGTC/TGTGGA 4 N D mis11Minor allele frequency- T:0.50NA 2
    rs12147491,2
    C,F,A,H--43418733(+) AAGTCG/ATGGAC 4 /H syn1 ese328Minor allele frequency- A:0.32MN EA NS NA WA CSA EU 9464
    rs1462725671,2
    C,F--43418773(+) ATGGGC/TGGCTG 4 H R mis11Minor allele frequency- T:0.00NA 4486
    rs2003690851,2
    --43418787(+) CAGTCA/GTCCAG 4 D syn10--------
    rs748713661,2
    C--43418848(+) AGCGGG/TTTATG 4 N T mis10--------
    rs342771041,2
    C,F--43418886(+) CAAGGC/TCGCAT 4 R syn13Minor allele frequency- T:0.01NA WA 4732
    rs1431491401,2
    F--43418888(+) AGGCCG/ACATCA 4 /R /W mis11Minor allele frequency- A:0.00NA 4542

    HapMap Linkage Disequilibrium report for DLK2 (43418090 - 43424370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DLK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6841n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLK2
    DNA2.0 Custom Variant and Variant Library Synthesis for DLK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DLK2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DLK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis. (PubMed id 17320102)1 Nueda M.L....Laborda J. (J. Mol. Biol. 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 65989 HGNC: 21113 AceView: EGFL9 Ensembl:ENSG00000171462 euGenes: HUgn65989
    ECgene: DLK2 H-InvDB: DLK2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DLK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DLK2 gene:
    Search GeneIP for patents involving DLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for DLK2 (DLK2/EGFL9)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DLK2  
     OriGene qPCR primer pairs and template standards for DLK2   OriGene Protein Over-expression Lysate for DLK2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DLK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for DLK2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DLK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DLK2   OriGene Custom Protein Services for DLK2  

     
     
     Block miRNA regulation of human, mouse, rat DLK2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DLK2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLK2 Predesigned siRNA for gene silencing in human, mouse, rat DLK2
     QuantiFast Probe-based Assays in human, mouse, rat DLK2 QuantiTect SYBR Green Assays in human, mouse, rat DLK2
     Custom PCR Arrays for DLK2 Search Chromatin IP Primers for DLK2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLK2  Search GeneGlobe Interaction Network for DLK2
     Regulatory tfbs in DLK2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DLK2 GenScript cDNA clones with any tag delivered in your preferred vector for DLK2
     GenScript Custom Assay Services for DLK2 GenScript Custom overexpressing Cell Line Services for DLK2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DLK2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DLK2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for DLK2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DLK2 antibodies
     DLK2 proteins
     DLK2 lysates
     Antibodies for DLK2
     See all of Abcam's Antibodies, Kits and Proteins for DLK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for DLK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK2
     SwitchGear 3'UTR luciferase reporter plasmids for DLK2
     SwitchGear Promoter luciferase reporter plasmids for DLK2
     Search ThermoFisher Antibodies for DLK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLK2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLK2
     LSBio Antibodies in human, mouse, rat for DLK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DLK2
      Search eBioscience for proteins for DLK2
      Search eBioscience for elisas for DLK2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DLK2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4