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Aliases for DLK2 Gene

Aliases for DLK2 Gene

  • Delta-Like 2 Homolog (Drosophila) 2 3 5
  • Epidermal Growth Factor-Like Protein 9 3 4
  • EGF-Like-Domain, Multiple 9 2 3
  • EGF-Like Protein 9 3 4
  • EGFL9 3 4
  • DLK-2 3 4

External Ids for DLK2 Gene

Previous HGNC Symbols for DLK2 Gene

  • EGFL9

Previous GeneCards Identifiers for DLK2 Gene

  • GC06M043528
  • GC06M043136

Summaries for DLK2 Gene

GeneCards Summary for DLK2 Gene

DLK2 (Delta-Like 2 Homolog (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is NOTCH2NL.

UniProtKB/Swiss-Prot for DLK2 Gene

  • Regulates adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLK2 Gene

Genomics for DLK2 Gene

Regulatory Elements for DLK2 Gene

Enhancers for DLK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DLK2 on UCSC Golden Path with GeneCards custom track

Promoters for DLK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLK2 Gene

Chromosome:
6
Start:
43,450,352 bp from pter
End:
43,456,632 bp from pter
Size:
6,281 bases
Orientation:
Minus strand

Genomic View for DLK2 Gene

Genes around DLK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLK2 Gene

Proteins for DLK2 Gene

  • Protein details for DLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UY11-DLK2_HUMAN
    Recommended name:
    Protein delta homolog 2
    Protein Accession:
    Q6UY11
    Secondary Accessions:
    • B3KNZ7
    • Q5T3T8
    • Q9BQ54

    Protein attributes for DLK2 Gene

    Size:
    383 amino acids
    Molecular mass:
    40548 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLK2 Gene

Proteomics data for DLK2 Gene at MOPED

Post-translational modifications for DLK2 Gene

  • Glycosylation at Asn 157
  • Modification sites at PhosphoSitePlus

Other Protein References for DLK2 Gene

No data available for DME Specific Peptides for DLK2 Gene

Domains & Families for DLK2 Gene

Suggested Antigen Peptide Sequences for DLK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UY11

UniProtKB/Swiss-Prot:

DLK2_HUMAN :
  • Contains 6 EGF-like domains.
Domain:
  • Contains 6 EGF-like domains.
genes like me logo Genes that share domains with DLK2: view

No data available for Gene Families for DLK2 Gene

Function for DLK2 Gene

Molecular function for DLK2 Gene

UniProtKB/Swiss-Prot Function:
Regulates adipogenesis.

Gene Ontology (GO) - Molecular Function for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with DLK2: view
genes like me logo Genes that share phenotypes with DLK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DLK2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DLK2 Gene

Localization for DLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLK2 Gene COMPARTMENTS Subcellular localization image for DLK2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DLK2: view

Pathways & Interactions for DLK2 Gene

SuperPathways for DLK2 Gene

No Data Available

SIGNOR curated interactions for DLK2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DLK2 Gene

None

No data available for Pathways by source for DLK2 Gene

Drugs & Compounds for DLK2 Gene

No Compound Related Data Available

Transcripts for DLK2 Gene

Unigene Clusters for DLK2 Gene

Delta-like 2 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for DLK2 Gene

GeneLoc Exon Structure for
DLK2
ECgene alternative splicing isoforms for
DLK2

Expression for DLK2 Gene

mRNA expression in normal human tissues for DLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLK2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.2).

SOURCE GeneReport for Unigene cluster for DLK2 Gene Hs.337251

genes like me logo Genes that share expression patterns with DLK2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DLK2 Gene

Orthologs for DLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLK2 35
  • 88.95 (n)
  • 92.17 (a)
DLK2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLK2 35
  • 89.38 (n)
  • 91.91 (a)
DLK2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlk2 35
  • 89.18 (n)
  • 92.41 (a)
Dlk2 16
Dlk2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLK2 35
  • 99.56 (n)
  • 99.74 (a)
DLK2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlk2 35
  • 89.18 (n)
  • 91.62 (a)
oppossum
(Monodelphis domestica)
Mammalia DLK2 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLK2 35
  • 66.03 (n)
  • 65.31 (a)
DLK2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLK2 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dlk2 35
  • 58.1 (n)
  • 55.42 (a)
dlk2 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wry 36
  • 7 (a)
OneToMany
Species with no ortholog for DLK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLK2 Gene

ENSEMBL:
Gene Tree for DLK2 (if available)
TreeFam:
Gene Tree for DLK2 (if available)

Paralogs for DLK2 Gene

(7) SIMAP similar genes for DLK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLK2: view

Variants for DLK2 Gene

Sequence variations from dbSNP and Humsavar for DLK2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_048977 -
rs1674851 -- 43,457,407(+) ttttg(G/T)ggccc upstream-variant-2KB
rs11423507 -- 43,457,197(+) TTTTT(-/T)GACGT upstream-variant-2KB
rs12183668 -- 43,458,612(+) aggtg(A/G)gagga upstream-variant-2KB
rs12527928 -- 43,457,673(+) gcccC(C/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DLK2 Gene

Variant ID Type Subtype PubMed ID
dgv6841n71 CNV Loss 21882294

Variation tolerance for DLK2 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DLK2 Gene

Disorders for DLK2 Gene

Relevant External Links for DLK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLK2

No disorders were found for DLK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLK2 Gene

Publications for DLK2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells. (PMID: 25093684) Nueda M.L. … Laborda J. (Biochim. Biophys. Acta 2014) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis. (PMID: 17320102) Nueda M.L. … Laborda J. (J. Mol. Biol. 2007) 3

Products for DLK2 Gene

Sources for DLK2 Gene

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