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Aliases for DLK2 Gene

Aliases for DLK2 Gene

  • Delta-Like 2 Homolog (Drosophila) 2 3
  • Epidermal Growth Factor-Like Protein 9 3 4
  • EGF-Like-Domain, Multiple 9 2 3
  • EGF-Like Protein 9 3 4
  • EGFL9 3 4
  • DLK-2 3 4
  • Protein Delta Homolog 2 3

External Ids for DLK2 Gene

Previous HGNC Symbols for DLK2 Gene

  • EGFL9

Previous GeneCards Identifiers for DLK2 Gene

  • GC06M043528
  • GC06M043136

Summaries for DLK2 Gene

GeneCards Summary for DLK2 Gene

DLK2 (Delta-Like 2 Homolog (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is NOTCH2.

UniProtKB/Swiss-Prot for DLK2 Gene

  • Regulates adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLK2 Gene

Genomics for DLK2 Gene

Regulatory Elements for DLK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DLK2 Gene

43,450,352 bp from pter
43,456,632 bp from pter
6,281 bases
Minus strand

Genomic View for DLK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLK2 Gene

Proteins for DLK2 Gene

  • Protein details for DLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein delta homolog 2
    Protein Accession:
    Secondary Accessions:
    • B3KNZ7
    • Q5T3T8
    • Q9BQ54

    Protein attributes for DLK2 Gene

    383 amino acids
    Molecular mass:
    40548 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLK2 Gene


neXtProt entry for DLK2 Gene

Proteomics data for DLK2 Gene at MOPED

Post-translational modifications for DLK2 Gene

  • Glycosylation at Asn157
  • Modification sites at PhosphoSitePlus

Other Protein References for DLK2 Gene

No data available for DME Specific Peptides for DLK2 Gene

Domains for DLK2 Gene

Suggested Antigen Peptide Sequences for DLK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 EGF-like domains.
  • Contains 6 EGF-like domains.
genes like me logo Genes that share domains with DLK2: view

No data available for Gene Families for DLK2 Gene

Function for DLK2 Gene

Molecular function for DLK2 Gene

UniProtKB/Swiss-Prot Function:
Regulates adipogenesis.

Gene Ontology (GO) - Molecular Function for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with DLK2: view

Phenotypes for DLK2 Gene

GenomeRNAi human phenotypes for DLK2:
genes like me logo Genes that share phenotypes with DLK2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLK2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DLK2 Gene

Localization for DLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for DLK2 Gene COMPARTMENTS Subcellular localization image for DLK2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DLK2: view

Pathways for DLK2 Gene

SuperPathways for DLK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045598 regulation of fat cell differentiation IEA --
GO:0045746 negative regulation of Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with DLK2: view

No data available for Pathways by source for DLK2 Gene

Transcripts for DLK2 Gene

Unigene Clusters for DLK2 Gene

Delta-like 2 homolog (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for DLK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLK2 Gene

mRNA expression in normal human tissues for DLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLK2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.2).

SOURCE GeneReport for Unigene cluster for DLK2 Gene Hs.337251

genes like me logo Genes that share expressions with DLK2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for DLK2 Gene

Orthologs for DLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DLK2 35
  • 88.95 (n)
  • 92.17 (a)
DLK2 36
  • 92 (a)
(Canis familiaris)
Mammalia DLK2 35
  • 89.38 (n)
  • 91.91 (a)
DLK2 36
  • 92 (a)
(Mus musculus)
Mammalia Dlk2 35
  • 89.18 (n)
  • 92.41 (a)
Dlk2 16
Dlk2 36
  • 83 (a)
(Pan troglodytes)
Mammalia DLK2 35
  • 99.56 (n)
  • 99.74 (a)
DLK2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dlk2 35
  • 89.18 (n)
  • 91.62 (a)
(Monodelphis domestica)
Mammalia DLK2 36
  • 57 (a)
(Gallus gallus)
Aves DLK2 35
  • 66.03 (n)
  • 65.31 (a)
DLK2 36
  • 59 (a)
(Anolis carolinensis)
Reptilia DLK2 36
  • 57 (a)
(Danio rerio)
Actinopterygii dlk2 35
  • 58.1 (n)
  • 55.42 (a)
dlk2 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta wry 36
  • 7 (a)
Species with no ortholog for DLK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLK2 Gene

Gene Tree for DLK2 (if available)
Gene Tree for DLK2 (if available)

Paralogs for DLK2 Gene

(7) SIMAP similar genes for DLK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLK2: view

Variants for DLK2 Gene

Sequence variations from dbSNP and Humsavar for DLK2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3734687 -- 43,455,909(+) AGATC(C/T)ATGCA intron-variant, upstream-variant-2KB
rs9349257 -- 43,458,080(+) TAACt(C/T)ttttt upstream-variant-2KB
rs9394953 -- 43,456,719(+) CCCCC(C/G)CCCCC upstream-variant-2KB
rs11423507 -- 43,457,197(+) TTTTT(-/T)GACGT upstream-variant-2KB
rs12183668 -- 43,458,612(+) aggtg(A/G)gagga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DLK2 Gene

Variant ID Type Subtype PubMed ID
dgv6841n71 CNV Loss 21882294

Relevant External Links for DLK2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLK2 Gene

Disorders for DLK2 Gene

No disorders were found for DLK2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DLK2 Gene

Publications for DLK2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for DLK2 Gene

Sources for DLK2 Gene

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