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Aliases for DLK2 Gene

Aliases for DLK2 Gene

  • Delta Like Non-Canonical Notch Ligand 2 2 3 5
  • Epidermal Growth Factor-Like Protein 9 3 4
  • EGF-Like-Domain, Multiple 9 2 3
  • EGF-Like Protein 9 3 4
  • EGFL9 3 4
  • DLK-2 3 4
  • Delta-Like 2 Homolog (Drosophila) 2
  • Protein Delta Homolog 2 3
  • Delta-Like 2 Homolog 3

External Ids for DLK2 Gene

Previous HGNC Symbols for DLK2 Gene

  • EGFL9

Previous GeneCards Identifiers for DLK2 Gene

  • GC06M043528
  • GC06M043136

Summaries for DLK2 Gene

GeneCards Summary for DLK2 Gene

DLK2 (Delta Like Non-Canonical Notch Ligand 2) is a Protein Coding gene. Among its related pathways are Canonical and Non-canonical Notch signaling and P38 MAPK Signaling Pathway (sino). GO annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is DLK1.

UniProtKB/Swiss-Prot for DLK2 Gene

  • Regulates adipogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLK2 Gene

Genomics for DLK2 Gene

Regulatory Elements for DLK2 Gene

Enhancers for DLK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G043261 1.6 FANTOM5 ENCODE dbSUPER 11.1 +194.3 194267 1.4 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 DNPH1 SLC22A7 ZNF318 RPL12P47 CRIP3 DLK2 ENSG00000245261 CUL9 YIPF3 POLR1C
GH06G043390 1.5 Ensembl ENCODE dbSUPER 11.2 +64.2 64180 3.5 HDGF PKNOX1 ARNT WRNIP1 E2F7 TCF12 ZNF766 GATA2 ZNF592 SMARCA4 ABCC10 RPL12P47 CRIP3 DLK2 TTBK1 DNPH1 POLR1C YIPF3 LRRC73 ZNF318
GH06G043382 1.4 Ensembl ENCODE dbSUPER 11.1 +72.8 72774 2.7 TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 YBX1 ZBTB40 YY1 EGR1 RCOR1 SLC22A7 ABCC10 RPL12P47 CRIP3 DLK2 TTBK1 DNPH1 RNU6-1113P TJAP1 POLR1C
GH06G043180 1.4 ENCODE dbSUPER 9.4 +274.5 274469 3.2 MLX CREB3L1 AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CUL7 DNPH1 BICRAL POLH RPS2P29 RPL34P14 KLC4 RN7SL403P UBR2 DLK2
GH06G043486 1.1 dbSUPER 11.9 -30.6 -30565 1.1 PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF143 ZNF416 DLK2 POLR1C LRRC73 YIPF3 RPS2P29 ENSG00000252218 TTBK1 DNPH1 CUL9 GTPBP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DLK2 on UCSC Golden Path with GeneCards custom track

Promoters for DLK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197132 1432 1201 PKNOX1 AGO1 ARID4B SIN3A ZNF2 ZBTB7B SLC30A9 ZNF416 ZNF143 DEK

Genomic Location for DLK2 Gene

Chromosome:
6
Start:
43,450,352 bp from pter
End:
43,456,632 bp from pter
Size:
6,281 bases
Orientation:
Minus strand

Genomic View for DLK2 Gene

Genes around DLK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLK2 Gene

Proteins for DLK2 Gene

  • Protein details for DLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UY11-DLK2_HUMAN
    Recommended name:
    Protein delta homolog 2
    Protein Accession:
    Q6UY11
    Secondary Accessions:
    • B3KNZ7
    • Q5T3T8
    • Q9BQ54

    Protein attributes for DLK2 Gene

    Size:
    383 amino acids
    Molecular mass:
    40548 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLK2 Gene

Post-translational modifications for DLK2 Gene

  • Glycosylation at Asn157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DLK2 Gene

Domains & Families for DLK2 Gene

Suggested Antigen Peptide Sequences for DLK2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLK2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DLK2 Gene

Function for DLK2 Gene

Molecular function for DLK2 Gene

UniProtKB/Swiss-Prot Function:
Regulates adipogenesis.

Gene Ontology (GO) - Molecular Function for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with DLK2: view
genes like me logo Genes that share phenotypes with DLK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DLK2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DLK2 Gene

Localization for DLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLK2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLK2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DLK2: view

Pathways & Interactions for DLK2 Gene

genes like me logo Genes that share pathways with DLK2: view

Pathways by source for DLK2 Gene

1 Sino Biological pathway for DLK2 Gene
1 BioSystems pathway for DLK2 Gene

Interacting Proteins for DLK2 Gene

SIGNOR curated interactions for DLK2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045598 regulation of fat cell differentiation IEA --
GO:0045746 negative regulation of Notch signaling pathway IDA 25093684
genes like me logo Genes that share ontologies with DLK2: view

Drugs & Compounds for DLK2 Gene

No Compound Related Data Available

Transcripts for DLK2 Gene

Unigene Clusters for DLK2 Gene

Delta-like 2 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLK2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for DLK2 Gene

GeneLoc Exon Structure for
DLK2
ECgene alternative splicing isoforms for
DLK2

Expression for DLK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLK2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of DLK2 Gene:

DLK2

SOURCE GeneReport for Unigene cluster for DLK2 Gene:

Hs.337251

Evidence on tissue expression from TISSUES for DLK2 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with DLK2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLK2 Gene

Orthologs for DLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLK2 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia DLK2 34 35
  • 89.38 (n)
mouse
(Mus musculus)
Mammalia Dlk2 34 16 35
  • 89.18 (n)
rat
(Rattus norvegicus)
Mammalia Dlk2 34
  • 89.18 (n)
cow
(Bos Taurus)
Mammalia DLK2 34 35
  • 88.95 (n)
oppossum
(Monodelphis domestica)
Mammalia DLK2 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLK2 34 35
  • 66.03 (n)
lizard
(Anolis carolinensis)
Reptilia DLK2 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dlk2 34 35
  • 58.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta wry 35
  • 7 (a)
OneToMany
Species where no ortholog for DLK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLK2 Gene

ENSEMBL:
Gene Tree for DLK2 (if available)
TreeFam:
Gene Tree for DLK2 (if available)

Paralogs for DLK2 Gene

Paralogs for DLK2 Gene

(7) SIMAP similar genes for DLK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLK2: view

Variants for DLK2 Gene

Sequence variations from dbSNP and Humsavar for DLK2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000752713 -- 43,454,561(+) TTCCA(C/G)TAACT intron-variant, upstream-variant-2KB
rs1000838366 -- 43,454,578(+) ACTCA(A/G)CCCTA intron-variant, upstream-variant-2KB
rs1000908391 -- 43,454,252(+) GAAGC(A/G)AGAGA intron-variant, upstream-variant-2KB
rs1001140674 -- 43,457,943(+) TTGAC(-/CAT)CTCCC upstream-variant-2KB
rs1001274998 -- 43,457,673(+) CCCCT(-/A)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DLK2 Gene

Variant ID Type Subtype PubMed ID
nsv1074396 CNV deletion 25765185
nsv1144143 CNV deletion 24896259
nsv603000 CNV loss 21841781
nsv950172 CNV deletion 24416366

Variation tolerance for DLK2 Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLK2 Gene

Disorders for DLK2 Gene

Relevant External Links for DLK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLK2

No disorders were found for DLK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLK2 Gene

Publications for DLK2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells. (PMID: 25093684) Nueda M.L. … Laborda J. (Biochim. Biophys. Acta 2014) 3 64

Products for DLK2 Gene

Sources for DLK2 Gene

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