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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLK1 Gene

protein-coding   GIFtS: 61
GCID: GC14P101193

delta-like 1 homolog (Drosophila)

(Previous name: delta-like homolog (Drosophila) )
 Explore 46 diseases affiliated with
DLK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DLK1    

Aliases
for DLK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Delta-Like 1 Homolog (Drosophila)1 2     DLK-12 3
PG21     PREF12 5
FA11 2 5     Delta-Like Homolog (Drosophila)1
Delta11 2     Fetal Antigen 12
Pref-11 2     Preadipocyte Factor 12
ZOG1 2     Protein Delta Homolog 12
DLK2 3     Secredeltin1

External Ids:    HGNC: 29071   Entrez Gene: 87882   Ensembl: ENSG000001855597   OMIM: 1762905   UniProtKB: P803703   

Export aliases for DLK1 gene to outside databases

Previous GC identifers: GC14P098584 GC14P095008 GC14P099183 GC14P100263 GC14P081373


Summaries
for DLK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DLK1:
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in
the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is
one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can
cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed
from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The
mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first
described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370
Function: May have a role in neuroendocrine differentiation

Gene Wiki entry for DLK1


Genomic Views
for DLK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLK1 gene promoter:
         PPAR-gamma1   PPAR-gamma2   Evi-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32

DLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLK1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101193:  view genomic region     (about GC identifiers)

Start:
 101,192,042 bp from pter      End:
 101,201,539 bp from pter
Size:
 9,498 bases      Orientation:
 plus strand

Proteins
for DLK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370 (See protein sequence)
Recommended Name: Protein delta homolog 1 precursor  
Size: 383 amino acids; 41300 Da
Subunit: Monomer
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAA35582.1; Type=Frameshift; Positions=22, 108, 199;
Secondary accessions: P15803 Q96DW5
Alternative splicing: 2 isoforms:  P80370-1   P80370-2   

Explore the universe of human proteins at neXtProt for DLK1: NX_P80370

Post-translational modifications:

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P80370

    • DLK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003827.3  
    ENSEMBL proteins: 
     ENSP00000376589   ENSP00000340292   ENSP00000331081   ENSP00000450821  
    Reactome Protein details: P80370
    Human Recombinant Protein Products: 
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    Novus Biologicals DLK1 Protein
    Novus Biologicals DLK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DLK1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7925474
    GO:0005625soluble fraction ----
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    DLK1 for ontologies           About GeneDecksing



    DLK1 Antibody Products: 
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    GenScript Custom Assay Services for DLK1
    Enzo Life Sciences assays for DLK1
    Uscn ELISAs and CLIAs for DLK1

    Protein Domains /
    Families
    for DLK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DLK1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry P80370

    ProtoNet protein and cluster: P80370

    3 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB002049 Laminin-type EGF-like domain
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370
    Similarity: Contains 6 EGF-like domains


    Function
    for DLK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370
    Function: May have a role in neuroendocrine differentiation

         Genatlas biochemistry entry for DLK1:
    delta (Drosophila)-like 1,member of the EGF-like homeotic family,involved in cell differentiation in a
    justacrine/paracrine manner and in the pathogenesis of NF1,participating in the control of cell differentiation of
    several cell type,including small cell lung cancer lines,immune stem cells,B cells and adrenal glumerulose cells

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLK1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DLK1:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmid: DLK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: DLK1
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK1 

    Cell Line
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    LifeMap BioReagents: cell lines associated with DLK1: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor,
    PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor, PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DLK1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    DLK1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DLK1:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for DLK1: Dlk1tm1Srba Dlk1tm1Hsul
         13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dlk1):
     adipose tissue  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  other 
     reproductive system  skeleton  vision/eye 

    DLK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DLK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		FBXW7 Mutants and NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH1 HD Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    2Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    3Disease
    		Disease1.00
    4Adipogenesis
    		Adipogenesis1.00
    5Notch signaling pathway
    		Notch signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DLK1
        Wnt / Hedgehog / Notch

    3 BioSystems Pathways for DLK1 
        Adipogenesis
    Notch signaling pathway
    FOXA2 and FOXA3 transcription factor networks

    5/11        Reactome Pathways for DLK1 (see all 11)
        Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease



    DLK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DLK1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DLK1 (P803703 ENSP000003402924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAS1P548263, ENSP000002987434I2D: score=2 STRING: ENSP00000298743
    GRNP287993, ENSP000000538674I2D: score=2 STRING: ENSP00000053867
    FOXA2ENSP000003159554STRING: ENSP00000315955
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway TAS--
    GO:0007275multicellular organismal development TAS8500166
    GO:0009790embryo development ----
    GO:0009791post-embryonic development IEA--
    GO:0045746negative regulation of Notch signaling pathway IEA--


    DLK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DLK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DLK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLK1
    7 Novoseek chemical compound relationships for DLK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ibmx 50.8 10 19427405 (4), 9001251 (1), 12651852 (1), 10212243 (1)
    dexamethasone 31.2 20 10212243 (8), 19427405 (3), 9001251 (1), 11126233 (1) (see all 6)
    lipid 17 2 19427405 (1), 11988086 (1)
    cyclic amp 15.8 2 19427405 (1), 1322787 (1)
    glucose 0 1 12588883 (1)
    calcium 0 1 9202217 (1)
    tyrosine 0 2 1982060 (2)

    Search CenterWatch for drugs/clinical trials and news about DLK1 

    Transcripts
    for DLK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DLK1 gene (2 alternative transcripts): 
    NM_003836.5  NM_001032997.1  

    Unigene Cluster for DLK1:

    Delta-like 1 homolog (Drosophila)
    Hs.533717  [show with all ESTs]
    Unigene Representative Sequence: NM_003836
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392848 ENST00000341267(uc001yhu.4 uc001yhs.4) ENST00000555747
    ENST00000331224 ENST00000556051

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DLK1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DLK1:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmid: DLK1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLK1 (see all 7)
    OriGene shRNA RFP: DLK1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLK1
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLK1

    Additional cDNA sequence: 

    AK289384.1 AK297918.1 AK313258.1 BC007741.2 BC013197.1 BC014015.2 DQ017081.1 DQ126100.1 
    DQ138965.1 DQ309460.1 U15979.1 U15981.1 X17544.1 Z12172.1 

    24/62 DOTS entries (see all 62):

    DT.416769  DT.100721913  DT.100721971  DT.100857428  DT.100854210  DT.100721902  DT.100638897  DT.100721928 
    DT.100848612  DT.100870905  DT.100872922  DT.100721918  DT.100721975  DT.100852322  DT.100721910  DT.95076423 
    DT.100852632  DT.100870812  DT.120790229  DT.100719123  DT.100721923  DT.100721924  DT.100721964  DT.100855049 

    24/1111 AceView cDNA sequences (see all 1111):

    CR610630 CR621769 CR590000 CR612731 CR590868 CR610667 CR609887 CR595013 
    BF058541 CR611100 CR592735 BU074128 CA335243 BQ478098 CR610043 CR611562 
    CR604853 BM508935 CR600320 CR614142 CR617526 CR622612 CR620437 CR603336 

    GeneLoc Exon Structure


    Expression
    for DLK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATACAGAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DLK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/39 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 39) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeSubcutaneous White AdipocytesAdipose
    AdiposeCervical Brown Adipose DepotCervical Brown Adipocyte CellsAdipose
    AdiposeCranial Subcutaneous White AdiposeSubcutaneous White AdipocytesAdipose
    AdiposeFacial Subcutaneous White AdiposeSubcutaneous White AdipocytesAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Brown Adipocyte CellsAdipose
    AdiposeSacral Brown Adipose DepotSacral Brown Adipocyte CellsAdipose
    AdiposeSubcutaneous White AdiposeBrown-like Adipocyte CellsAdipose
    AdiposeSubcutaneous White AdiposeSubcutaneous White AdipocytesAdipose
    AdiposeThoracic Brown Adipose DepotThoracic Brown Adipocyte CellsAdipose
    AdiposeVisceral White AdiposeBrown-like Adipocyte CellsAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/23 LifeMap Cells (see all 23) 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See DLK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLK1

    SOURCE GeneReport for Unigene cluster: Hs.533717

    UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370
    Tissue specificity: Found within the stromal cells in close contact to the vascular structure of placental villi, yolk
    sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas.
    Found also in some forms of neuroendocrine lung tumor tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including DLK1: 
              Parkinson's Disease in human mouse rat
              WNT Signaling Targets in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DLK1

    Orthologs
    for DLK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DLK1 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DLK11 delta-like 1 homolog (Drosophila) 58.64(n)
    55.81(a)    		   423459  NM_001142254.1  NP_001135726.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DLK16
    		 --
    		 49(a)
    		 1 ↔ 1
    		 GL343270.1(246095-253610)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01102109.16
    FP102164.16
    		 --
    		 38(a)
    21(a)
    		 1 ↔ 1
    possible ortholog
    		 17(40370-48551)
    21(5028934-5036108)
    worm
    (Caenorhabditis elegans)    		 Secernentea F55G1.136
    F55G1.126
    		 Protein F55G1.12
    		 8(a)
    5(a)
    		 1 ↔ many
    1 ↔ many
    		 IV(7495345-7497839)
    IV(7493832-7495286)


    ENSEMBL Gene Tree for DLK1 (if available)
    TreeFam Gene Tree for DLK1 (if available) 

    Paralogs
    for DLK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLK1 gene
    DLK22  ENSG000002551682  NOTCH2NL2  
    14 SIMAP similar genes for DLK1 using alignment to 7 protein entries:     DLK1_HUMAN (see all proteins):
    JAG1    DLL1    F9    FAT3    NOTCH1    JAG2
    SLIT2    DLK2    SVEP1    NOTCH2NL    DLL4    NELL1
    SLIT1    NOTCH4

    DLK1 for paralogs           About GeneDecksing



    Genomic Variants
    for DLK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/184 NCBI SNPs in DLK1 are shown (see all 184)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1927969041,2
    		--101191217(+) GAAGAC/TCTTGG 1 -- us2k10--------
    rs170996371,2
    		C,F,H,--101191320(+) CATCAC/TTGAAG 1 -- us2k121Minor allele frequency- T:0.13NA NS EA CSA WA 2268
    rs740789311,2
    		C,F,--101191338(+) CTTGAC/TTTGAG 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs1845879061,2
    		--101191367(+) AAGTAC/GGGTCA 1 -- us2k10--------
    rs761331321,2
    		F,--101191370(+) TAGGGT/ACACAG 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs733436501,2
    		C,--101191437(+) TGTCCC/TCAAAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1150911921,2
    		F,--101191638(+) GGATGC/ACCATG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1898677111,2
    		--101191650(+) GCCTGC/TCTTCC 1 -- us2k10--------
    rs793281491,2
    		F,--101191965(+) TTTCTG/AAGCCT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs124355031,2
    		C,H,--101192059(+) GGGTGC/TCTGAG 1 -- us2k111Minor allele frequency- T:0.05NA WA CSA EA 373

    HapMap Linkage Disequilibrium report for DLK1 (101192042 - 101201539 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DLK1
         1 CNV: 8776

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    Disorders / Diseases
    for DLK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DLK1 for disorders           About GeneDecksing

    OMIM gene information: 176290    OMIM disorders: --

    20/46 diseases for DLK1 (see all 46):    About MalaCards
    maternal uniparental disomy, chromosome 14    obesity    muscle hypertrophy    multiple endocrine neoplasia
    visceral leishmaniasis    glucose intolerance    atrophic gastritis    angiomatosis
    biliary atresia    anorexia nervosa    neuroendocrine tumor    pancreatic endocrine tumors
    myelodysplastic syndrome    ganglioneuroblastoma    ganglioneuroma    pituitary adenoma
    leishmaniasis    lipoma    neurofibroma    angelman syndrome

    6 Novoseek disease relationships for DLK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuroendocrine tumors 57.1 4 10668203 (1), 19477929 (1), 16403460 (1)
    pheochromocytoma 38.4 6 7711066 (1), 10668203 (1), 16403460 (1)
    myelodysplastic syndromes 33.2 5 15289021 (2), 18575777 (2), 15806146 (1)
    tumors 6.86 25 19307926 (2), 19934310 (2), 7711066 (1), 18352842 (1) (see all 12)
    obesity 3.74 9 18392037 (6)
    necrosis 0 1 18392037 (1)

    Human Genome Epidemiology (HuGE) Navigator: DLK1 (6 documents)

    Export disorders for DLK1 gene to outside databases

    Publications
    for DLK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLK1 gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with DLK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. (PubMed id 7925474)1, 2, 3, 9 Jensen C.H.... Teisner B. (1994)
    2. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. (PubMed id 8095043)1, 2, 3 Laborda J.... Notario V. (1993)
    3. dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA. (PubMed id 7711066)1, 2, 9 Lee Y.L.... Laborda J. (1995)
    4. Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. (PubMed id 8501199)1, 2, 9 Jensen C.H.... Skjoedt K. (1993)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The sequence of an adrenal specific human cDNA, pG2. (PubMed id 2308864)1, 2 Helman L.J.... Israel M.A. (1990)
    8. FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression. (PubMed id 8985741)1, 9 Tornehave D....Larsson L.I. (1996)
    9. Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma. (PubMed id 20214740)1, 9 Yu F....Li J. (2010)
    10. Dlk1 in normal and abnormal hematopoiesis. (PubMed id 15959531)1, 9 Sakajiri S....Koeffler H.P. (2005)

    External Searches for DLK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DLK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8788 HGNC: 2907 AceView: DLK1 Ensembl:ENSG00000185559 euGenes: HUgn8788
    ECgene: DLK1 H-InvDB: DLK1

    Other Databases showing DLK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DLK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DLK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DLK1 gene:
    Search GeneIP for patents involving DLK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     DLK1 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Lines associated with DLK1: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor,
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