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DLK1 Gene

protein-coding   GIFtS: 63
GCID: GC14P101197

Delta-Like 1 Homolog (Drosophila)

(Previous name: delta-like homolog (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Delta-Like 1 Homolog (Drosophila)1 2     Delta12
DLK2 3     Pref-12
DLK-12 3     ZOG2
pG22 3     Fetal Antigen 12
FA12 5     Preadipocyte Factor 12
PREF12 5     Protein Delta Homolog 12
Delta-Like Homolog (Drosophila)1     secredeltin2

External Ids:    HGNC: 29071   Entrez Gene: 87882   Ensembl: ENSG000001855597   OMIM: 1762905   UniProtKB: P803703   

Export aliases for DLK1 gene to outside databases

Previous GC identifers: GC14P098584 GC14P095008 GC14P099183 GC14P100263 GC14P101193 GC14P081373


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLK1 Gene:
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved
in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor.
It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted
region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This
gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and
adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian
inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle
hypertrophy and decreased fat mass. (provided by RefSeq, Mar 2010)

GeneCards Summary for DLK1 Gene:
DLK1 (delta-like 1 homolog (Drosophila)) is a protein-coding gene. Diseases associated with DLK1 include maternal uniparental disomy, chromosome 14, and uniparental disomy, paternal, chromosome 14. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370
Function: May have a role in neuroendocrine differentiation

Gene Wiki entry for DLK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLK1 gene promoter:
         PPAR-gamma1   PPAR-gamma2   Evi-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLK1 promoter sequence
   Search Chromatin IP Primers for DLK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32

DLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLK1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101197:  view genomic region     (about GC identifiers)

Start:
101,192,042 bp from pter      End:
101,201,539 bp from pter
Size:
9,498 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370 (See protein sequence)
Recommended Name: Protein delta homolog 1 precursor  
Size: 383 amino acids; 41300 Da
Subunit: Monomer
Sequence caution: Sequence=CAA35582.1; Type=Frameshift; Positions=22, 108, 199;
Secondary accessions: P15803 Q96DW5
Alternative splicing: 2 isoforms:  P80370-1   P80370-2   

Explore the universe of human proteins at neXtProt for DLK1: NX_P80370

Explore proteomics data for DLK1 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • Glycosylation2 at Ser94, Asn100, Thr143, Ser163, Asn165, Asn172, Ser214, Thr222, Ser251, Thr256,
                                 Ser260, Thr269
  • Modification sites at PhosphoSitePlus

  • See DLK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003827.3  
    ENSEMBL proteins: 
     ENSP00000376589   ENSP00000340292   ENSP00000331081   ENSP00000450821  
    Reactome Protein details: P80370

    DLK1 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for DLK1
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    OriGene Protein Over-expression Lysate for DLK1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DLK1
    GenScript Custom Purified and Recombinant Proteins Services for DLK1
    Novus Biologicals DLK1 Protein
    Novus Biologicals DLK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    DLK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DLK1
    R&D Systems Antibodies for DLK1 (Pref-1/DLK1/FA1)
    Cell Signaling Technology (CST) Antibodies for DLK1 
    OriGene Antibodies for DLK1
    OriGene Custom Antibody Services for DLK1
    Novus Biologicals DLK1 Antibodies
    Abcam antibodies for DLK1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for DLK1
    LSBio Antibodies in human, mouse, rat for DLK1

    DLK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DLK1
    R&D Systems ELISAs for DLK1 (Pref-1/DLK1/FA1)         (see all)
    GenScript Custom Assay Services for DLK1
    Enzo Life Sciences assays for DLK1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P80370

    ProtoNet protein and cluster: P80370

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB002049 Laminin-type EGF-like domain
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370
    Similarity: Contains 6 EGF-like domains


    DLK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLK1_HUMAN, P80370
    Function: May have a role in neuroendocrine differentiation

         Genatlas biochemistry entry for DLK1:
    delta (Drosophila)-like 1,member of the EGF-like homeotic family,involved in cell differentiation in a
    justacrine/paracrine manner and in the pathogenesis of NF1,participating in the control of cell differentiation
    of several cell type,including small cell lung cancer lines,immune stem cells,B cells and adrenal glumerulose
    cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
         
    DLK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DLK1:
     Decreased Hepatitis C virus re  Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dlk1):
     adipose tissue  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  reproductive system  skeleton  vision/eye 

    DLK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DLK1: Dlk1tm1Srba Dlk1tm1Hsul

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLK1

    miRNA
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    miRTarBase miRNAs that target DLK1:
    hsa-mir-15a-5p (MIRT032077)

    Block miRNA regulation of human, mouse, rat DLK1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DLK1:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidDLK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLK1
    Predesigned siRNA for gene silencing in human, mouse, rat DLK1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DLK1

    Clone
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    OriGene ORF clones in mouse, rat for DLK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLK1 (NM_003836)
    Sino Biological Human cDNA Clone for DLK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLK1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DLK1
    ESI BIO PureStem Progenitors for DLK1: 
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor,
    PureStem SM30, NCr-fac & Meso-latp Progenitor, PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLK1_HUMAN, P80370: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane3
    nucleus2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7925474
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    DLK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DLK1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH0.64
    2Signaling by NOTCH2
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    3Signaling by GPCR
    Signal Transduction0.58
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5Notch Signaling Pathways
    Notch Signaling Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DLK1
        Notch Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for DLK1
        Wnt / Hedgehog / Notch

    3 BioSystems Pathways for DLK1
        Adipogenesis
    FOXA2 and FOXA3 transcription factor networks
    Notch signaling pathway


    1 Reactome Pathway for DLK1
        Activated NOTCH1 Transmits Signal to the Nucleus



    DLK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLK1: 
              Parkinson's Disease in human mouse rat
              WNT Signaling Targets in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DLK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for DLK1 (P803703 ENSP000003402924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GAS1P548263, ENSP000002987434I2D: score=2 STRING: ENSP00000298743
    GRNP287993, ENSP000000538674I2D: score=2 STRING: ENSP00000053867
    NOTCH2ENSP000002566464STRING: ENSP00000256646
    NOTCH2NLENSP000003549294STRING: ENSP00000354929
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007219Notch signaling pathway TAS--
    GO:0007275multicellular organismal development TAS8500166
    GO:0009790embryo development ----
    GO:0009791post-embryonic development IEA--
    GO:0030154cell differentiation IEA--

    DLK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLK1

    7 Novoseek inferred chemical compound relationships for DLK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ibmx 50.8 10 19427405 (4), 9001251 (1), 12651852 (1), 10212243 (1)
    dexamethasone 31.2 20 10212243 (8), 19427405 (3), 9001251 (1), 11126233 (1) (see all 6)
    lipid 17 2 19427405 (1), 11988086 (1)
    cyclic amp 15.8 2 19427405 (1), 1322787 (1)
    glucose 0 1 12588883 (1)
    calcium 0 1 9202217 (1)
    tyrosine 0 2 1982060 (2)



    DLK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DLK1 gene (2 alternative transcripts): 
    NM_003836.5  NM_001032997.1  

    Unigene Cluster for DLK1:

    Delta-like 1 homolog (Drosophila)
    Hs.533717  [show with all ESTs]
    Unigene Representative Sequence: NM_003836
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392848 ENST00000341267(uc001yhu.4 uc001yhs.4) ENST00000555747
    ENST00000331224 ENST00000556051
    miRNA
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    Block miRNA regulation of human, mouse, rat DLK1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DLK1:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidDLK1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DLK1 (NM_003836)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLK1
      QuantiTect SYBR Green Assays in human, mouse, rat DLK1
      QuantiFast Probe-based Assays in human, mouse, rat DLK1

    Additional mRNA sequence: 

    AK289384.1 AK297918.1 AK313258.1 BC007741.2 BC013197.1 BC014015.2 DQ017081.1 DQ126100.1 
    DQ138965.1 DQ309460.1 U15979.1 U15981.1 X17544.1 Z12172.1 

    Selected DOTS entries (see all 62):

    DT.416769  DT.100721913  DT.100721971  DT.100857428  DT.100854210  DT.100721902  DT.100638897  DT.100721928 
    DT.100848612  DT.100870905  DT.100872922  DT.100721918  DT.100721975  DT.100852322  DT.100721910  DT.95076423 
    DT.100852632  DT.100870812  DT.120790229  DT.100719123  DT.100721923  DT.100721924  DT.100721964  DT.100855049 

    Selected AceView cDNA sequences (see all 1111):

    CR610630 CR621769 CR612731 CR590000 CR590868 CR610667 CR609887 CR595013 
    BF058541 CR611100 CR592735 CA335243 BU074128 BQ478098 CR600320 CR610043 
    BM508935 CR611562 CR604853 CR614142 CR617526 CR603336 CR622612 CR620437 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACAGAATA
    DLK1 Expression
    About this image


    DLK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 30) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 25 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced SM30 cells
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Mandibular Process
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             HyStem+BMP4-induced SM30 cells
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
             Floor plate-like cells
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Common Preadipocyte Lateral Plate Mesoderm
             PureStem SM30, NCr-fac & Meso-latp Progenitor
    DLK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533717

    UniProtKB/Swiss-Prot: DLK1_HUMAN, P80370
    Tissue specificity: Found within the stromal cells in close contact to the vascular structure of placental villi,
    yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult
    pancreas. Found also in some forms of neuroendocrine lung tumor tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLK1: 
              Parkinson's Disease in human mouse rat
              WNT Signaling Targets in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DLK1
    OriGene qSTAR qPCR primer pairs in human, mouse for DLK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLK1
    QuantiTect SYBR Green Assays in human, mouse, rat DLK1
    QuantiFast Probe-based Assays in human, mouse, rat DLK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlk11 , 5 delta-like 1 homolog (Drosophila)1, 5 87.03(n)1
    86.16(a)1
      12 (60.17 cM)5
    133861  NM_010052.51  NP_034182.21 
     1094528235 
    chicken
    (Gallus gallus)
    Aves DLK11 delta-like 1 homolog (Drosophila) 58.57(n)
    55.65(a)
      423459  NM_001142254.1  NP_001135726.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLK16
    delta-like 1 homolog (Drosophila)
    50(a)
    1 ↔ 1
    GL343270.1(246311-258108)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dlk11 delta-like 1 homolog (Drosophila) 54.85(n)
    51.95(a)
      100494606  XM_002936578.2  XP_002936624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018833411 protein delta homolog 1-like 55.9(n)
    41.16(a)
      101883341  XM_005173564.1  XP_005173621.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wry6
    weary
    7(a)
    1 → many
    2L(1836630-1858550)


    ENSEMBL Gene Tree for DLK1 (if available)
    TreeFam Gene Tree for DLK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLK1 gene
    DLK22  SNED12  NOTCH42  NOTCH12  DLL32  NOTCH32  JAG22  CRB22  
    DLL42  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    13 SIMAP similar genes for DLK1 using alignment to 7 protein entries:     DLK1_HUMAN (see all proteins):
    JAG1    DLL1    F9    FAT3    NOTCH1    JAG2
    SLIT2    DLK2    SVEP1    NOTCH2NL    DLL4    NELL1
    SLIT1

    DLK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLK1 (see all 259)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927969041,2
    --101191217(+) GAAGAC/TCTTGG 1 -- us2k10--------
    rs170996371,2
    C,F,H--101191320(+) CATCAC/TTGAAG 1 -- us2k121Minor allele frequency- T:0.13NA NS EA CSA WA 2268
    rs740789311,2
    C,F--101191338(+) CTTGAC/TTTGAG 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs1845879061,2
    --101191367(+) AAGTAC/GGGTCA 1 -- us2k10--------
    rs761331321,2
    F--101191370(+) TAGGGT/ACACAG 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs733436501,2
    C,F--101191437(+) TGTCCC/TCAAAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1150911921,2
    C,F--101191638(+) GGATGC/ACCATG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1898677111,2
    --101191650(+) GCCTGC/TCTTCC 1 -- us2k10--------
    rs793281491,2
    C,F--101191965(+) TTTCTG/AAGCCT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs124355031,2
    C,H--101192059(+) GGGTGC/TCTGAG 1 -- us2k111Minor allele frequency- T:0.05NA WA CSA EA 373

    HapMap Linkage Disequilibrium report for DLK1 (101192042 - 101201539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DLK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1425CNV Insertion18451855
    nsv456428CNV Loss19166990
    nsv521690CNV Loss19592680
    nsv832876CNV Loss17160897
    nsv525723CNV Loss19592680
    nsv470668CNV Loss18288195
    esv2751158CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLK1
    DNA2.0 Custom Variant and Variant Library Synthesis for DLK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176290    OMIM disorders: --

    Selected diseases for DLK1 (see all 45):    
    About MalaCards
    maternal uniparental disomy, chromosome 14    uniparental disomy, paternal, chromosome 14    angiomatosis    ganglioneuroblastoma
    neuroendocrine tumor    ganglioneuroma    phaeochromocytoma    myelodysplastic syndromes
    atrophic gastritis    pancreatic endocrine tumors    neurofibroma    biliary atresia
    obesity    lipoma    visceral leishmaniasis    anorexia nervosa
    glucose intolerance    gastritis    leishmaniasis    multiple endocrine neoplasia


    DLK1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for DLK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuroendocrine tumors 57.1 4 10668203 (1), 19477929 (1), 16403460 (1)
    pheochromocytoma 38.4 6 7711066 (1), 10668203 (1), 16403460 (1)
    myelodysplastic syndromes 33.2 5 15289021 (2), 18575777 (2), 15806146 (1)
    tumors 6.86 25 19307926 (2), 19934310 (2), 7711066 (1), 18352842 (1) (see all 12)
    obesity 3.74 9 18392037 (6)
    necrosis 0 1 18392037 (1)

    Genetic Association Database (GAD): DLK1
    Human Genome Epidemiology (HuGE) Navigator: DLK1 (6 documents)

    Export disorders for DLK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLK1 gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with DLK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. (PubMed id 7925474)1, 2, 3, 9 Jensen C.H.... Teisner B. (Eur. J. Biochem. 1994)
    2. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. (PubMed id 8095043)1, 2, 3 Laborda J.... Notario V. (J. Biol. Chem. 1993)
    3. dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA. (PubMed id 7711066)1, 2, 9 Lee Y.L.... Laborda J. (Biochim. Biophys. Acta 1995)
    4. Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. (PubMed id 8501199)1, 2, 9 Jensen C.H.... Skjoedt K. (Hum. Reprod. 1993)
    5. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. (PubMed id 19966805)1, 4 Wallace C....Clayton D.G. (Nat. Genet. 2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. (PubMed id 18398438)1, 4 Wermter A.K....BrAPnner G. (Eur. J. Hum. Genet. 2008)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. (PubMed id 12768436)1, 4 Lee J.K....Jo I. (J. Hum. Genet. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8788 HGNC: 2907 AceView: DLK1 Ensembl:ENSG00000185559 euGenes: HUgn8788
    ECgene: DLK1 H-InvDB: DLK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DLK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DLK1 gene:
    Search GeneIP for patents involving DLK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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