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Aliases for DLGAP5 Gene

Aliases for DLGAP5 Gene

  • Discs, Large (Drosophila) Homolog-Associated Protein 5 2 3
  • Disks Large-Associated Protein DLG7 3 4
  • Hepatoma Up-Regulated Protein 3 4
  • Discs Large Homolog 7 3 4
  • DAP-5 3 4
  • DLG7 3 4
  • HURP 3 4
  • Discs, Large Homolog 7 (Drosophila) 2
  • Disks Large-Associated Protein 5 3
  • Discs, Large Homolog 7 3
  • KIAA0008 4

External Ids for DLGAP5 Gene

Previous HGNC Symbols for DLGAP5 Gene

  • DLG7

Previous GeneCards Identifiers for DLGAP5 Gene

  • GC14M054685
  • GC14M055614
  • GC14M035777

Summaries for DLGAP5 Gene

GeneCards Summary for DLGAP5 Gene

DLGAP5 (Discs, Large (Drosophila) Homolog-Associated Protein 5) is a Protein Coding gene. Among its related pathways are Aurora A signaling. GO annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is DLGAP3.

UniProtKB/Swiss-Prot for DLGAP5 Gene

  • Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Gene Wiki entry for DLGAP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP5 Gene

Genomics for DLGAP5 Gene

Regulatory Elements for DLGAP5 Gene

Genomic Location for DLGAP5 Gene

Start:
55,148,112 bp from pter
End:
55,191,678 bp from pter
Size:
43,567 bases
Orientation:
Minus strand

Genomic View for DLGAP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP5 Gene

Proteins for DLGAP5 Gene

  • Protein details for DLGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15398-DLGP5_HUMAN
    Recommended name:
    Disks large-associated protein 5
    Protein Accession:
    Q15398
    Secondary Accessions:
    • A8MTM6
    • B4DRM8
    • Q86T11
    • Q8NG58

    Protein attributes for DLGAP5 Gene

    Size:
    846 amino acids
    Molecular mass:
    95115 Da
    Quaternary structure:
    • Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.
    SequenceCaution:
    • Sequence=BAA02797.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62583.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DLGAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLGAP5 Gene

Proteomics data for DLGAP5 Gene at MOPED

Post-translational modifications for DLGAP5 Gene

  • Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
  • Ubiquitinated, leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLGAP5 Gene

No data available for DME Specific Peptides for DLGAP5 Gene

Domains for DLGAP5 Gene

Protein Domains for DLGAP5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DLGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15398

UniProtKB/Swiss-Prot:

DLGP5_HUMAN :
  • Q15398
Family:
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP5: view

No data available for Gene Families for DLGAP5 Gene

Function for DLGAP5 Gene

Molecular function for DLGAP5 Gene

UniProtKB/Swiss-Prot Function: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Gene Ontology (GO) - Molecular Function for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity ISS --
GO:0005515 protein binding IPI 15145941
genes like me logo Genes that share ontologies with DLGAP5: view

Phenotypes for DLGAP5 Gene

genes like me logo Genes that share phenotypes with DLGAP5: view

Animal Models for DLGAP5 Gene

MGI Knock Outs for DLGAP5:

Animal Model Products

CRISPR Products

miRNA for DLGAP5 Gene

miRTarBase miRNAs that target DLGAP5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLGAP5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DLGAP5 Gene

Localization for DLGAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLGAP5 Gene COMPARTMENTS Subcellular localization image for DLGAP5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0031616 spindle pole centrosome ISS --
genes like me logo Genes that share ontologies with DLGAP5: view

Pathways for DLGAP5 Gene

SuperPathways for DLGAP5 Gene

Superpath Contained pathways
1 Aurora A signaling
genes like me logo Genes that share pathways with DLGAP5: view

Pathways by source for DLGAP5 Gene

1 BioSystems pathway for DLGAP5 Gene

Gene Ontology (GO) - Biological Process for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007079 mitotic chromosome movement towards spindle pole NAS 12527899
GO:0007267 cell-cell signaling --
GO:0008283 cell proliferation NAS 12527899
GO:0016311 dephosphorylation ISS --
GO:0023052 signaling IEA --
genes like me logo Genes that share ontologies with DLGAP5: view

Compounds for DLGAP5 Gene

(1) Novoseek inferred chemical compound relationships for DLGAP5 Gene

Compound -log(P) Hits PubMed IDs
guanylate 42.7 2
genes like me logo Genes that share compounds with DLGAP5: view

Transcripts for DLGAP5 Gene

Unigene Clusters for DLGAP5 Gene

Discs, large (Drosophila) homolog-associated protein 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLGAP5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP1: -
SP2:
SP3: - - - -
SP4:
SP5:
SP6:

ExUns: 20 ^ 21a · 21b · 21c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for DLGAP5 Gene

GeneLoc Exon Structure for
DLGAP5
ECgene alternative splicing isoforms for
DLGAP5

Expression for DLGAP5 Gene

mRNA expression in normal human tissues for DLGAP5 Gene

mRNA differential expression in normal tissues according to GTEx for DLGAP5 Gene

This gene is overexpressed in Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLGAP5 Gene

SOURCE GeneReport for Unigene cluster for DLGAP5 Gene Hs.77695

mRNA Expression by UniProt/SwissProt for DLGAP5 Gene

Q15398-DLGP5_HUMAN
Tissue specificity: Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
genes like me logo Genes that share expressions with DLGAP5: view

In Situ Assay Products

Orthologs for DLGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLGAP5 35
  • 99.29 (n)
  • 98.46 (a)
DLGAP5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLGAP5 35
  • 87.54 (n)
  • 78.2 (a)
DLGAP5 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLGAP5 35
  • 85.7 (n)
  • 76.76 (a)
DLGAP5 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlgap5 35
  • 72.13 (n)
  • 60.99 (a)
Dlgap5 16
Dlgap5 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DLGAP5 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlgap5 35
  • 71 (n)
  • 57.92 (a)
chicken
(Gallus gallus)
Aves DLGAP5 35
  • 56.72 (n)
  • 44.13 (a)
DLGAP5 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLGAP5 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.531 35
zebrafish
(Danio rerio)
Actinopterygii dlgap5 35
  • 48.78 (n)
  • 39.75 (a)
dlgap5 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mars 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1632 36
  • 28 (a)
OneToOne
Species with no ortholog for DLGAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP5 Gene

ENSEMBL:
Gene Tree for DLGAP5 (if available)
TreeFam:
Gene Tree for DLGAP5 (if available)

Paralogs for DLGAP5 Gene

Paralogs for DLGAP5 Gene

Pseudogenes.org Pseudogenes for DLGAP5 Gene

genes like me logo Genes that share paralogs with DLGAP5: view

Variants for DLGAP5 Gene

Sequence variations from dbSNP and Humsavar for DLGAP5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs15870 -- 55,152,593(-) GAAAA(C/T)CATGT synonymous-codon, reference
rs1202728 -- 55,191,979(-) gcagt(G/T)agcag upstream-variant-2KB
rs1202729 -- 55,191,936(-) acaga(A/G)acctt upstream-variant-2KB
rs1202730 -- 55,191,340(-) ACCGT(G/T)TTACC intron-variant
rs1202731 -- 55,191,264(-) ATAGT(C/G)AGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP5 Gene

Variant ID Type Subtype PubMed ID
esv2673073 CNV Deletion 23128226

Relevant External Links for DLGAP5 Gene

HapMap Linkage Disequilibrium report
DLGAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP5 Gene

Disorders for DLGAP5 Gene

(3) Novoseek inferred disease relationships for DLGAP5 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 46 4
tumors 0 5
cancer 0 1

Relevant External Links for DLGAP5

Genetic Association Database (GAD)
DLGAP5
genes like me logo Genes that share disorders with DLGAP5: view

No data available for UniProtKB/Swiss-Prot for DLGAP5 Gene

Publications for DLGAP5 Gene

  1. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. (PMID: 12527899) Tsou A.-P. … Chou C.-K. (Oncogene 2003) 3 4 23
  2. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B- phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. (PMID: 15145941) Hsu J.-M. … Huang C.-Y.F. (J. Biol. Chem. 2004) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  4. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. (PMID: 15987997) Yu C.T. … Huang C.Y. (Mol. Cell. Biol. 2005) 3 4 23
  5. Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1. (PMID: 11543626) Bassal S. … van der Spek P.J. (Genomics 2001) 3 23

Products for DLGAP5 Gene

Sources for DLGAP5 Gene

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