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Aliases for DLGAP5 Gene

Aliases for DLGAP5 Gene

  • DLG Associated Protein 5 2 3 5
  • Discs Large Homolog Associated Protein 5 2 3
  • Disks Large-Associated Protein DLG7 3 4
  • Hepatoma Up-Regulated Protein 3 4
  • DAP-5 3 4
  • DLG7 3 4
  • HURP 3 4
  • Discs, Large (Drosophila) Homolog-Associated Protein 5 2
  • Discs, Large Homolog 7 (Drosophila) 2
  • Disks Large-Associated Protein 5 3
  • Discs, Large Homolog 7 3
  • Discs Large Homolog 7 4
  • KIAA0008 4

External Ids for DLGAP5 Gene

Previous HGNC Symbols for DLGAP5 Gene

  • DLG7

Previous GeneCards Identifiers for DLGAP5 Gene

  • GC14M054685
  • GC14M055614
  • GC14M035777

Summaries for DLGAP5 Gene

GeneCards Summary for DLGAP5 Gene

DLGAP5 (DLG Associated Protein 5) is a Protein Coding gene. Diseases associated with DLGAP5 include Hepatocellular Carcinoma. Among its related pathways are Aurora A signaling. GO annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is DLGAP2.

UniProtKB/Swiss-Prot for DLGAP5 Gene

  • Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Gene Wiki entry for DLGAP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP5 Gene

Genomics for DLGAP5 Gene

Regulatory Elements for DLGAP5 Gene

Enhancers for DLGAP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F055135 1.3 Ensembl ENCODE 11.6 +54.5 54486 2.7 CTCF PKNOX1 RAD21 OSR2 JUND CTBP1 PBX2 NR2F6 KDM1A PRDM1 LOC105370509 DLGAP5 LGALS3
GH14F055152 1.1 ENCODE 11.5 +39.4 39441 0.2 PAF1 CEBPB FOS LGALS3 DLGAP5
GH14F055097 1.2 FANTOM5 Ensembl ENCODE 11.3 +88.3 88274 12.7 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 SLC30A9 CBX5 LGALS3 LOC105370509 MAPK1IP1L GCH1 DLGAP5 FBXO34 ENSG00000259318 ATG14 GC14M055058 GC14M055059
GH14F055084 0.5 ENCODE 11.2 +106.4 106385 1.6 HLF CUX1 ZNF652 SPI1 LOC105370509 MAPK1IP1L LGALS3 DLGAP5 GC14M055058 GC14M055059
GH14F055365 0.5 ENCODE 11.1 -174.8 -174810 1.8 SP5 TEAD1 DPF2 FEZF1 ZNF644 TEAD3 JUND HNF1A FOSL2 FOS LOC105370509 DLGAP5 TBPL2 ENSG00000259318 PIR52112 PIR53477
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DLGAP5 on UCSC Golden Path with GeneCards custom track

Promoters for DLGAP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000418206 278 2400 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ELK1 ZNF143 FOS CEBPZ

Genomic Location for DLGAP5 Gene

Chromosome:
14
Start:
55,148,112 bp from pter
End:
55,191,678 bp from pter
Size:
43,567 bases
Orientation:
Minus strand

Genomic View for DLGAP5 Gene

Genes around DLGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP5 Gene

Proteins for DLGAP5 Gene

  • Protein details for DLGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15398-DLGP5_HUMAN
    Recommended name:
    Disks large-associated protein 5
    Protein Accession:
    Q15398
    Secondary Accessions:
    • A8MTM6
    • B4DRM8
    • Q86T11
    • Q8NG58

    Protein attributes for DLGAP5 Gene

    Size:
    846 amino acids
    Molecular mass:
    95115 Da
    Quaternary structure:
    • Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.
    SequenceCaution:
    • Sequence=BAA02797.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62583.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DLGAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLGAP5 Gene

Post-translational modifications for DLGAP5 Gene

  • Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
  • Ubiquitinated, leading to its degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLGAP5 Gene

Antibody Products

  • Abcam antibodies for DLGAP5

No data available for DME Specific Peptides for DLGAP5 Gene

Domains & Families for DLGAP5 Gene

Protein Domains for DLGAP5 Gene

Suggested Antigen Peptide Sequences for DLGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15398

UniProtKB/Swiss-Prot:

DLGP5_HUMAN :
  • Belongs to the SAPAP family.
Family:
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP5: view

No data available for Gene Families for DLGAP5 Gene

Function for DLGAP5 Gene

Molecular function for DLGAP5 Gene

UniProtKB/Swiss-Prot Function:
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Gene Ontology (GO) - Molecular Function for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity ISS --
GO:0005515 protein binding IPI 15145941
genes like me logo Genes that share ontologies with DLGAP5: view
genes like me logo Genes that share phenotypes with DLGAP5: view

Animal Models for DLGAP5 Gene

MGI Knock Outs for DLGAP5:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLGAP5 Gene

Localization for DLGAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLGAP5 Gene COMPARTMENTS Subcellular localization image for DLGAP5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DLGAP5: view

Pathways & Interactions for DLGAP5 Gene

SuperPathways for DLGAP5 Gene

SuperPathway Contained pathways
1 Aurora A signaling
genes like me logo Genes that share pathways with DLGAP5: view

Pathways by source for DLGAP5 Gene

1 BioSystems pathway for DLGAP5 Gene

Gene Ontology (GO) - Biological Process for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007079 mitotic chromosome movement towards spindle pole NAS 12527899
GO:0008283 cell proliferation NAS 12527899
GO:0023052 signaling IEA --
genes like me logo Genes that share ontologies with DLGAP5: view

No data available for SIGNOR curated interactions for DLGAP5 Gene

Drugs & Compounds for DLGAP5 Gene

(1) Additional Compounds for DLGAP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLGAP5: view

Transcripts for DLGAP5 Gene

Unigene Clusters for DLGAP5 Gene

Discs, large (Drosophila) homolog-associated protein 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP1: -
SP2:
SP3: - - - -
SP4:
SP5:
SP6:

ExUns: 20 ^ 21a · 21b · 21c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for DLGAP5 Gene

GeneLoc Exon Structure for
DLGAP5
ECgene alternative splicing isoforms for
DLGAP5

Expression for DLGAP5 Gene

mRNA expression in normal human tissues for DLGAP5 Gene

mRNA differential expression in normal tissues according to GTEx for DLGAP5 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for DLGAP5 Gene

This gene is overexpressed in Testis (28.1), Plasma (24.7), and Heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DLGAP5 Gene



Protein tissue co-expression partners for DLGAP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DLGAP5 Gene:

DLGAP5

SOURCE GeneReport for Unigene cluster for DLGAP5 Gene:

Hs.77695

mRNA Expression by UniProt/SwissProt for DLGAP5 Gene:

Q15398-DLGP5_HUMAN
Tissue specificity: Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
genes like me logo Genes that share expression patterns with DLGAP5: view

Primer Products

Orthologs for DLGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLGAP5 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia DLGAP5 34 35
  • 87.54 (n)
dog
(Canis familiaris)
Mammalia DLGAP5 34 35
  • 85.7 (n)
mouse
(Mus musculus)
Mammalia Dlgap5 34 16 35
  • 72.13 (n)
rat
(Rattus norvegicus)
Mammalia Dlgap5 34
  • 71 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DLGAP5 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLGAP5 34 35
  • 56.72 (n)
lizard
(Anolis carolinensis)
Reptilia DLGAP5 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.531 34
zebrafish
(Danio rerio)
Actinopterygii dlgap5 34 35
  • 48.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta mars 35
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1632 35
  • 28 (a)
OneToOne
Species where no ortholog for DLGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP5 Gene

ENSEMBL:
Gene Tree for DLGAP5 (if available)
TreeFam:
Gene Tree for DLGAP5 (if available)

Paralogs for DLGAP5 Gene

Paralogs for DLGAP5 Gene

Pseudogenes.org Pseudogenes for DLGAP5 Gene

genes like me logo Genes that share paralogs with DLGAP5: view

Variants for DLGAP5 Gene

Sequence variations from dbSNP and Humsavar for DLGAP5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10132251 -- 55,158,947(+) ggagt(C/T)tgcag intron-variant
rs10133318 -- 55,155,963(+) gcagg(C/G/T)gcctg intron-variant
rs10134800 -- 55,168,491(+) TTTTC(A/G)ATGTC intron-variant
rs10134983 -- 55,168,605(+) AGTAA(C/T)TTCTT intron-variant
rs10135042 -- 55,168,505(+) TGTTG(C/G)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP5 Gene

Variant ID Type Subtype PubMed ID
esv2673073 CNV deletion 23128226
esv3584459 CNV gain 25503493
esv3634572 CNV loss 21293372
esv3634573 CNV gain 21293372
esv3634575 CNV gain 21293372
nsv1035158 CNV gain 25217958
nsv1113654 CNV deletion 24896259
nsv474886 CNV novel sequence insertion 20440878

Variation tolerance for DLGAP5 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.22; 95.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLGAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLGAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP5 Gene

Disorders for DLGAP5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DLGAP5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DLGAP5

Genetic Association Database (GAD)
DLGAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLGAP5
genes like me logo Genes that share disorders with DLGAP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLGAP5 Gene

Publications for DLGAP5 Gene

  1. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. (PMID: 15987997) Yu C.T. … Huang C.Y. (Mol. Cell. Biol. 2005) 3 4 22 64
  2. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B- phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. (PMID: 15145941) Hsu J.-M. … Huang C.-Y.F. (J. Biol. Chem. 2004) 3 4 22 64
  3. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. (PMID: 12527899) Tsou A.-P. … Chou C.-K. (Oncogene 2003) 3 4 22 64
  4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
  5. Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene. (PMID: 17322106) Gudmundsson K.O. … Rafnar T. (Stem Cells 2007) 3 22 64

Products for DLGAP5 Gene

Sources for DLGAP5 Gene

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