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Aliases for DLGAP4 Gene

Aliases for DLGAP4 Gene

  • Discs, Large (Drosophila) Homolog-Associated Protein 4 2 3
  • SAP90/PSD-95-Associated Protein 4 3 4
  • PSD-95/SAP90-Binding Protein 4 3 4
  • SAPAP-4 3 4
  • SAPAP4 3 4
  • DAP-4 3 4
  • DAP4 3 4
  • Disks Large-Associated Protein 4 3
  • KIAA0964 4
  • DLP4 3

External Ids for DLGAP4 Gene

Previous GeneCards Identifiers for DLGAP4 Gene

  • GC20P035609
  • GC20P034429
  • GC20P034894
  • GC20P031731

Summaries for DLGAP4 Gene

Entrez Gene Summary for DLGAP4 Gene

  • The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLGAP4 Gene

DLGAP4 (Discs, Large (Drosophila) Homolog-Associated Protein 4) is a Protein Coding gene. An important paralog of this gene is DLGAP3.

UniProtKB/Swiss-Prot for DLGAP4 Gene

  • May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane

Gene Wiki entry for DLGAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP4 Gene

Genomics for DLGAP4 Gene

Regulatory Elements for DLGAP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DLGAP4 Gene

Start:
36,306,336 bp from pter
End:
36,528,637 bp from pter
Size:
222,302 bases
Orientation:
Plus strand

Genomic View for DLGAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLGAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP4 Gene

Proteins for DLGAP4 Gene

  • Protein details for DLGAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2H0-DLGP4_HUMAN
    Recommended name:
    Disks large-associated protein 4
    Protein Accession:
    Q9Y2H0
    Secondary Accessions:
    • E1P5T5
    • Q5QPG4
    • Q5T2Y4
    • Q5T2Y5
    • Q9H137
    • Q9H138
    • Q9H1L7

    Protein attributes for DLGAP4 Gene

    Size:
    992 amino acids
    Molecular mass:
    108012 Da
    Quaternary structure:
    • Interacts with DLG1 and DLG4/PSD-95.
    SequenceCaution:
    • Sequence=BAA76808.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DLGAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLGAP4 Gene

Proteomics data for DLGAP4 Gene at MOPED

Post-translational modifications for DLGAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DLGAP4 Gene

Domains for DLGAP4 Gene

Protein Domains for DLGAP4 Gene

Suggested Antigen Peptide Sequences for DLGAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2H0

UniProtKB/Swiss-Prot:

DLGP4_HUMAN :
  • Q9Y2H0
Family:
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP4: view

No data available for Gene Families for DLGAP4 Gene

Function for DLGAP4 Gene

Molecular function for DLGAP4 Gene

UniProtKB/Swiss-Prot Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane

Gene Ontology (GO) - Molecular Function for DLGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275660
genes like me logo Genes that share ontologies with DLGAP4: view

Phenotypes for DLGAP4 Gene

GenomeRNAi human phenotypes for DLGAP4:
genes like me logo Genes that share phenotypes with DLGAP4: view

Animal Model Products

CRISPR Products

miRNA for DLGAP4 Gene

miRTarBase miRNAs that target DLGAP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLGAP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DLGAP4 Gene

Localization for DLGAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP4 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLGAP4 Gene COMPARTMENTS Subcellular localization image for DLGAP4 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DLGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with DLGAP4: view

Pathways for DLGAP4 Gene

SuperPathways for DLGAP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLGAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling --
GO:0023052 signaling IEA --
genes like me logo Genes that share ontologies with DLGAP4: view

No data available for Pathways by source for DLGAP4 Gene

Transcripts for DLGAP4 Gene

Unigene Clusters for DLGAP4 Gene

Discs, large (Drosophila) homolog-associated protein 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLGAP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ·
SP1:
SP2: - - - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - -
SP11: - -
SP12: -
SP13:
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - -
SP18: - - - - -
SP19: - - - - - -
SP20:
SP21:
SP22: - - - - - -
SP23: - - - - - -
SP24: - - - - - -
SP25: - - - - - -
SP26: - - - -
SP27: - -
SP28: - -
SP29:
SP30: -
SP31:
SP32: - - -

ExUns: 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c · 22d · 22e · 22f ^ 23a · 23b · 23c · 23d ^ 24a · 24b ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - -
SP6:
SP7: - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - -
SP14:
SP15: - - - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - -
SP20: - - - - - - - - -
SP21: - -
SP22: - - - - - - - - -
SP23: - -
SP24:
SP25: - - - -
SP26: - - - -
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:

ExUns: 24c ^ 25a · 25b · 25c ^ 26a · 26b · 26c · 26d
SP1:
SP2: -
SP3: -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: - -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:

Relevant External Links for DLGAP4 Gene

GeneLoc Exon Structure for
DLGAP4
ECgene alternative splicing isoforms for
DLGAP4

Expression for DLGAP4 Gene

mRNA expression in normal human tissues for DLGAP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLGAP4 Gene

SOURCE GeneReport for Unigene cluster for DLGAP4 Gene Hs.249600

genes like me logo Genes that share expressions with DLGAP4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DLGAP4 Gene

Orthologs for DLGAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLGAP4 35
  • 99.6 (n)
  • 99.8 (a)
DLGAP4 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLGAP4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLGAP4 35
  • 91.89 (n)
  • 95.54 (a)
DLGAP4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlgap4 35
  • 89.42 (n)
  • 94.93 (a)
Dlgap4 16
Dlgap4 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLGAP4 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLGAP4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlgap4 35
  • 89.28 (n)
  • 94.22 (a)
chicken
(Gallus gallus)
Aves DLGAP4 35
  • 73.26 (n)
  • 74.51 (a)
DLGAP4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLGAP4 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22327 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dlgap4 35
  • 65.98 (n)
  • 65.18 (a)
Str.5427 35
zebrafish
(Danio rerio)
Actinopterygii dlgap4 35
  • 60.17 (n)
  • 58.14 (a)
dlgap4a 36
  • 53 (a)
OneToMany
dlgap4b 36
  • 50 (a)
OneToMany
wufk71g01 35
fruit fly
(Drosophila melanogaster)
Insecta vlc 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2669 36
  • 25 (a)
OneToMany
Species with no ortholog for DLGAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP4 Gene

ENSEMBL:
Gene Tree for DLGAP4 (if available)
TreeFam:
Gene Tree for DLGAP4 (if available)

Paralogs for DLGAP4 Gene

Paralogs for DLGAP4 Gene

Selected SIMAP similar genes for DLGAP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLGAP4: view

Variants for DLGAP4 Gene

Sequence variations from dbSNP and Humsavar for DLGAP4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs127416 -- 36,489,597(-) GAAAC(C/T)ATTCA intron-variant
rs220077 -- 36,499,222(+) TTTTT(C/T)CTCTC intron-variant
rs220078 -- 36,502,359(+) AAAAA(A/T)ttttt intron-variant
rs906466 -- 36,420,229(-) GTCTC(C/T)AGCAT intron-variant
rs906467 -- 36,420,192(-) TGTTC(A/G)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP4 Gene

Variant ID Type Subtype PubMed ID
esv2722371 CNV Deletion 23290073
esv2722372 CNV Deletion 23290073
esv2722374 CNV Deletion 23290073
nsv833966 CNV Gain+Loss 17160897
esv2722375 CNV Deletion 23290073
esv2665282 CNV Deletion 23128226
nsv521346 CNV Loss 19592680
nsv833967 CNV Loss 17160897

Relevant External Links for DLGAP4 Gene

HapMap Linkage Disequilibrium report
DLGAP4
Human Gene Mutation Database (HGMD)
DLGAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP4 Gene

Disorders for DLGAP4 Gene

Relevant External Links for DLGAP4

Genetic Association Database (GAD)
DLGAP4
Human Genome Epidemiology (HuGE) Navigator
DLGAP4
genes like me logo Genes that share disorders with DLGAP4: view

No data available for UniProtKB/Swiss-Prot for DLGAP4 Gene

Publications for DLGAP4 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  4. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. (PMID: 9115257) Takeuchi M. … Takai Y. (J. Biol. Chem. 1997) 2 3
  5. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. (PMID: 9581761) Kim J.H. … Huganir R.L. (Neuron 1998) 3

Products for DLGAP4 Gene

Sources for DLGAP4 Gene

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