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DLGAP4 Gene

protein-coding   GIFtS: 55
GCID: GC20P034894

Discs, Large (Drosophila) Homolog-Associated Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Discs, Large (Drosophila) Homolog-Associated Protein 41 2     SAP90/PSD-95-Associated Protein 42 3
DAP-42 3     DLP42
DAP42 3     Disks Large Associated Protein 42
SAPAP-42 3     Disks Large-Associated Protein 42
SAPAP42 3     KIAA09643
PSD-95/SAP90-Binding Protein 42 3     

External Ids:    HGNC: 244761   Entrez Gene: 228392   Ensembl: ENSG000000808457   UniProtKB: Q9Y2H03   

Export aliases for DLGAP4 gene to outside databases

Previous GC identifers: GC20P035609 GC20P034429 GC20P031731


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLGAP4 Gene:
The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal
cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other
signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase
domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of
at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLGAP4 Gene:
DLGAP4 (discs, large (Drosophila) homolog-associated protein 4) is a protein-coding gene. Diseases associated with DLGAP4 include transient cerebral ischemia, and ischemia. An important paralog of this gene is DLGAP1.

UniProtKB/Swiss-Prot: DLGP4_HUMAN, Q9Y2H0
Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an
adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the
plasma membrane

Gene Wiki entry for DLGAP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLGAP4 gene promoter:
         N-Myc   AP-1   Pax-2   Pax-2a   LyF-1   Ik-3   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DLGAP4 promoter sequence
   Search Chromatin IP Primers for DLGAP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLGAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

DLGAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLGAP4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P034894:  view genomic region     (about GC identifiers)

Start:
34,894,258 bp from pter      End:
35,157,040 bp from pter
Size:
262,783 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DLGP4_HUMAN, Q9Y2H0 (See protein sequence)
Recommended Name: Disks large-associated protein 4  
Size: 992 amino acids; 108012 Da
Subunit: Interacts with DLG1 and DLG4/PSD-95 (By similarity)
Sequence caution: Sequence=BAA76808.2; Type=Erroneous initiation;
Secondary accessions: E1P5T5 Q5QPG4 Q5T2Y4 Q5T2Y5 Q9H137 Q9H138 Q9H1L7
Alternative splicing: 3 isoforms:  Q9Y2H0-2   Q9Y2H0-1   Q9Y2H0-3   

Explore the universe of human proteins at neXtProt for DLGAP4: NX_Q9Y2H0

Explore proteomics data for DLGAP4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DLGAP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035951.1  NP_055717.2  NP_892118.1  

    ENSEMBL proteins: 
     ENSP00000363023   ENSP00000363014   ENSP00000345700   ENSP00000419311   ENSP00000384954  
     ENSP00000341633  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005026 GKAP

    Graphical View of Domain Structure for InterPro Entry Q9Y2H0

    ProtoNet protein and cluster: Q9Y2H0

    1 Blocks protein domain: IPB005026 Guanylate-kinase-associated protein

    UniProtKB/Swiss-Prot: DLGP4_HUMAN, Q9Y2H0
    Similarity: Belongs to the SAPAP family


    DLGAP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLGP4_HUMAN, Q9Y2H0
    Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an
    adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the
    plasma membrane

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16275660
         
    DLGAP4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DLGAP4:
     Decreased cell number  Synthetic lethal with gemcitab 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLGAP4
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    hsa-mir-26b-5p (MIRT028927), hsa-mir-3909 (MIRT052886)

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    Selected qRT-PCR Assays for microRNAs that regulate DLGAP4 (see all 63):
    hsa-miR-3164 hsa-miR-1321 hsa-let-7d hsa-miR-3146 hsa-miR-4305 hsa-miR-624 hsa-miR-30d hsa-miR-342-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLGP4_HUMAN, Q9Y2H0: Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--
    GO:0045202synapse IEA--

    DLGAP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DLGAP4
    Interactions:

        Search GeneGlobe Interaction Network for DLGAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DLGAP4 (Q9Y2H01, 2, 3 ENSP000003630234) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-722139,EBI-79464 MINT-8111859 I2D: score=2 STRING: ENSP00000274335
    BIN1O004991, 3, ENSP000003167794EBI-722139,EBI-719094 I2D: score=2 STRING: ENSP00000316779
    SYNGAP1Q96PV03, ENSP000004036364I2D: score=1 STRING: ENSP00000403636
    SRCP129312, 3, ENSP000003509414MINT-8113011 I2D: score=2 STRING: ENSP00000350941
    NCK1P163331, 3, ENSP000002889864EBI-722139,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling IEA--

    DLGAP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLGAP4 (DLGP4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DLGAP4 gene (3 alternative transcripts): 
    NM_001042486.2  NM_014902.4  NM_183006.2  

    Unigene Cluster for DLGAP4:

    Discs, large (Drosophila) homolog-associated protein 4
    Hs.249600  [show with all ESTs]
    Unigene Representative Sequence: AB023181
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373913(uc002xff.3 uc010zvp.2 uc002xfi.3) ENST00000373907
    ENST00000475894(uc002xfg.3 uc002xfh.3) ENST00000482872 ENST00000495241
    ENST00000491207 ENST00000482037 ENST00000340491 ENST00000479220 ENST00000489701
    ENST00000479951 ENST00000478910(uc002xfj.3) ENST00000497862 ENST00000477195
    ENST00000401952 ENST00000339266
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DLGAP4 (see all 63):
    hsa-miR-3164 hsa-miR-1321 hsa-let-7d hsa-miR-3146 hsa-miR-4305 hsa-miR-624 hsa-miR-30d hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidDLGAP4 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLGAP4
      QuantiTect SYBR Green Assays in human, mouse, rat DLGAP4
      QuantiFast Probe-based Assays in human, mouse, rat DLGAP4

    Additional mRNA sequence: 

    AB023181.1 AF088030.1 AK001681.1 AK055152.1 AK125383.1 BC023214.1 BC108706.1 BC118623.1 
    BC153874.1 

    Selected DOTS entries (see all 37):

    DT.101984702  DT.120811052  DT.95167549  DT.444460  DT.101984701  DT.100818012  DT.120811050  DT.100818019 
    DT.97860110  DT.100818008  DT.120810996  DT.120811065  DT.100818013  DT.120811086  DT.120811143  DT.120811096 
    DT.100731336  DT.120811113  DT.95167539  DT.120810995  DT.120811023  DT.120811031  DT.120811106  DT.92046179 

    Selected AceView cDNA sequences (see all 430):

    BI962714 CD365723 BG749580 AA443364 BM557894 Z42146 BF886506 BG748068 
    BM716452 CA427532 BQ943959 AI498534 AW298000 AI569056 BG680097 BU738248 
    BQ886910 BM711438 CA419678 BM819210 BE940559 AI652021 BQ084102 CA428880 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP4 (see all 32)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                        -     -     -     -     -     -                     
    SP3:                                                                                                                          -     -     -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c · 22d · 22e · 22f ^ 23a · 23b · 23c · 23d ^ 24a · 24b ·
    SP1:                                      -     -           -     -     -     -     -     -                                                                     
    SP2:                                      -     -     -     -                       -     -                                                                     
    SP3:                                      -     -     -     -                       -     -                                                                     
    SP4:                                      -     -     -     -                       -     -                                                                     
    SP5:                                                        -                       -     -                                                                     

    ExUns: 24c ^ 25a · 25b · 25c ^ 26a · 26b · 26c · 26d
    SP1:                                                
    SP2:                    -                           
    SP3:                    -                           
    SP4:        -           -                           
    SP5:                    -                           


    ECgene alternative splicing isoforms for DLGAP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLGAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGAGAAT
    DLGAP4 Expression
    About this image

    DLGAP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLGAP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249600
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLGAP4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlgap41 , 5 discs, large homolog-associated protein 4 (Drosophila)1, 5 89.42(n)1
    94.93(a)1
      2 (77.54 cM)5
    2288361  NM_146128.61  NP_666240.41 
     1566137055 
    chicken
    (Gallus gallus)
    Aves DLGAP41 discs, large (Drosophila) homolog-associated protein more 73.26(n)
    74.51(a)
      419119  XM_004946855.1  XP_004946912.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLGAP46
    discs, large (Drosophila) homolog-associated prote...
    73(a)
    1 ↔ 1
    4(138665743-138873344)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.223272 Xenopus laevis transcribed sequence with weak similarity more 77.84(n)    BX844912.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk71g012 Transcribed sequence with weak similarity to protein more 76.95(n)    AL915387.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vlc6
    vulcan
    20(a)
    1 → many
    2R(1589605-1592944)


    ENSEMBL Gene Tree for DLGAP4 (if available)
    TreeFam Gene Tree for DLGAP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLGAP4 gene
    DLGAP12  DLGAP22  DLGAP32  DLGAP52  
    3 SIMAP similar genes for DLGAP4 using alignment to 2 protein entries:     DLGP4_HUMAN (see all proteins):
    DLGAP2    DLGAP1    DLGAP3

    DLGAP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLGAP4 (see all 3050)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342729331,2
    C--31775652(+) TTTTT-/T/TTT 
            
    AACTC
    2 -- int1 cds11NA 2
    rs1909014821,2
    --31825056(+) AGTTTC/TGCTCT 1 -- us2k10--------
    rs1467616621,2
    C--34993747(+) TTTCCC/TGCCCT 1 -- us2k10--------
    rs1403807581,2
    --34993766(+) TCACAC/TCTTAT 1 -- us2k10--------
    rs60722221,2
    H--34993793(+) TTTTAT/GGCATC 1 -- us2k14Minor allele frequency- G:0.00NS EA 412
    rs1830598911,2
    --34993802(+) TCTTCA/GAGAAT 1 -- us2k10--------
    rs1158277761,2
    F--34993804(+) TTCGAG/CAATTT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1881941311,2
    --34993881(+) AGGTGG/TCTATG 1 -- us2k10--------
    rs1916933131,2
    --34993887(+) CTATGA/CCTGTT 1 -- us2k10--------
    rs1455394701,2
    C--34993940(+) TCCTGA/GAGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DLGAP4 (34894258 - 35144258 bp, first 250kb of DLGAP4)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DLGAP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665282CNV Deletion23128226
    esv2722375CNV Deletion23290073
    esv2722372CNV Deletion23290073
    esv2722371CNV Deletion23290073
    esv2722374CNV Deletion23290073
    nsv521346CNV Loss19592680
    nsv833967CNV Loss17160897
    nsv833966CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DLGAP4
    DNA2.0 Custom Variant and Variant Library Synthesis for DLGAP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for DLGAP4:    About MalaCards
    transient cerebral ischemia    ischemia    cerebritis    neuronitis


    DLGAP4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DLGAP4
    Human Genome Epidemiology (HuGE) Navigator: DLGAP4 (1 document)

    Export disorders for DLGAP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLGAP4 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with DLGAP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    4. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. (PubMed id 9115257)1, 3 Takeuchi M....Takai Y. (J. Biol. Chem. 1997)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22839 HGNC: 24476 AceView: DLGAP4 Ensembl:ENSG00000080845 euGenes: HUgn22839
    ECgene: DLGAP4 H-InvDB: DLGAP4

    (According to HUGE)
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    HUGE: KIAA0964

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DLGAP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DLGAP4 gene:
    Search GeneIP for patents involving DLGAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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