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Aliases for DLGAP4 Gene

Aliases for DLGAP4 Gene

  • Discs Large Homolog Associated Protein 4 2 3
  • Discs, Large (Drosophila) Homolog-Associated Protein 4 2 3 5
  • SAP90/PSD-95-Associated Protein 4 3 4
  • PSD-95/SAP90-Binding Protein 4 3 4
  • SAPAP-4 3 4
  • SAPAP4 3 4
  • DAP-4 3 4
  • DAP4 3 4
  • KIAA0964 4
  • DLP4 3

External Ids for DLGAP4 Gene

Previous GeneCards Identifiers for DLGAP4 Gene

  • GC20P035609
  • GC20P034429
  • GC20P034894
  • GC20P031731

Summaries for DLGAP4 Gene

Entrez Gene Summary for DLGAP4 Gene

  • The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLGAP4 Gene

DLGAP4 (Discs Large Homolog Associated Protein 4) is a Protein Coding gene. An important paralog of this gene is DLGAP3.

UniProtKB/Swiss-Prot for DLGAP4 Gene

  • May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

Gene Wiki entry for DLGAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP4 Gene

Genomics for DLGAP4 Gene

Regulatory Elements for DLGAP4 Gene

Genomic Location for DLGAP4 Gene

Chromosome:
20
Start:
36,306,323 bp from pter
End:
36,528,637 bp from pter
Size:
222,315 bases
Orientation:
Plus strand

Genomic View for DLGAP4 Gene

Genes around DLGAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLGAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLGAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP4 Gene

Proteins for DLGAP4 Gene

  • Protein details for DLGAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2H0-DLGP4_HUMAN
    Recommended name:
    Disks large-associated protein 4
    Protein Accession:
    Q9Y2H0
    Secondary Accessions:
    • E1P5T5
    • Q5QPG4
    • Q5T2Y4
    • Q5T2Y5
    • Q9H137
    • Q9H138
    • Q9H1L7

    Protein attributes for DLGAP4 Gene

    Size:
    992 amino acids
    Molecular mass:
    108012 Da
    Quaternary structure:
    • Interacts with DLG1 and DLG4/PSD-95.
    SequenceCaution:
    • Sequence=BAA76808.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DLGAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLGAP4 Gene

Proteomics data for DLGAP4 Gene at MOPED

Post-translational modifications for DLGAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DLGAP4 Gene

Domains & Families for DLGAP4 Gene

Protein Domains for DLGAP4 Gene

Suggested Antigen Peptide Sequences for DLGAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2H0

UniProtKB/Swiss-Prot:

DLGP4_HUMAN :
  • Belongs to the SAPAP family.
Family:
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP4: view

No data available for Gene Families for DLGAP4 Gene

Function for DLGAP4 Gene

Molecular function for DLGAP4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
genes like me logo Genes that share phenotypes with DLGAP4: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLGAP4 Gene

Localization for DLGAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP4 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLGAP4 Gene COMPARTMENTS Subcellular localization image for DLGAP4 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for DLGAP4 Gene

Pathways & Interactions for DLGAP4 Gene

SuperPathways for DLGAP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLGAP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DLGAP4 Gene

Drugs & Compounds for DLGAP4 Gene

No Compound Related Data Available

Transcripts for DLGAP4 Gene

Unigene Clusters for DLGAP4 Gene

Discs, large (Drosophila) homolog-associated protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ·
SP1:
SP2: - - - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - -
SP11: - -
SP12: -
SP13:
SP14: - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - -
SP18: - - - - -
SP19: - - - - - -
SP20:
SP21:
SP22: - - - - - -
SP23: - - - - - -
SP24: - - - - - -
SP25: - - - - - -
SP26: - - - -
SP27: - -
SP28: - -
SP29:
SP30: -
SP31:
SP32: - - -

ExUns: 17d ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c · 22d · 22e · 22f ^ 23a · 23b · 23c · 23d ^ 24a · 24b ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - -
SP6:
SP7: - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - -
SP14:
SP15: - - - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - -
SP20: - - - - - - - - -
SP21: - -
SP22: - - - - - - - - -
SP23: - -
SP24:
SP25: - - - -
SP26: - - - -
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:

ExUns: 24c ^ 25a · 25b · 25c ^ 26a · 26b · 26c · 26d
SP1:
SP2: -
SP3: -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: - -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:

Relevant External Links for DLGAP4 Gene

GeneLoc Exon Structure for
DLGAP4
ECgene alternative splicing isoforms for
DLGAP4

Expression for DLGAP4 Gene

mRNA expression in normal human tissues for DLGAP4 Gene

Protein differential expression in normal tissues from HIPED for DLGAP4 Gene

This gene is overexpressed in Fetal Brain (12.3), Peripheral blood mononuclear cells (9.7), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLGAP4 Gene



SOURCE GeneReport for Unigene cluster for DLGAP4 Gene Hs.249600

genes like me logo Genes that share expression patterns with DLGAP4: view

Protein tissue co-expression partners for DLGAP4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DLGAP4 Gene

Orthologs for DLGAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DLGAP4 35
  • 91.89 (n)
  • 95.54 (a)
DLGAP4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlgap4 35
  • 89.42 (n)
  • 94.93 (a)
Dlgap4 16
Dlgap4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLGAP4 35
  • 99.6 (n)
  • 99.8 (a)
DLGAP4 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlgap4 35
  • 89.28 (n)
  • 94.22 (a)
cow
(Bos Taurus)
Mammalia DLGAP4 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLGAP4 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLGAP4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLGAP4 35
  • 73.26 (n)
  • 74.51 (a)
DLGAP4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLGAP4 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlgap4 35
  • 65.98 (n)
  • 65.18 (a)
Str.5427 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22327 35
zebrafish
(Danio rerio)
Actinopterygii dlgap4 35
  • 60.17 (n)
  • 58.14 (a)
wufk71g01 35
dlgap4a 36
  • 53 (a)
OneToMany
dlgap4b 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta vlc 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2669 36
  • 25 (a)
OneToMany
Species with no ortholog for DLGAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP4 Gene

ENSEMBL:
Gene Tree for DLGAP4 (if available)
TreeFam:
Gene Tree for DLGAP4 (if available)

Paralogs for DLGAP4 Gene

Paralogs for DLGAP4 Gene

(3) SIMAP similar genes for DLGAP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLGAP4: view

Variants for DLGAP4 Gene

Sequence variations from dbSNP and Humsavar for DLGAP4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6019652 - 36,446,745(-) AGTCA(A/C/G/T)CCTGC nc-transcript-variant, reference, missense
VAR_057717 -
rs127416 -- 36,489,597(-) GAAAC(C/T)ATTCA intron-variant
rs1275391 -- 36,462,417(-) AAAGG(C/G)GGGCC intron-variant, utr-variant-5-prime
rs1275392 -- 36,434,261(+) TGAAC(A/G)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP4 Gene

Variant ID Type Subtype PubMed ID
esv2722371 CNV Deletion 23290073
esv2722372 CNV Deletion 23290073
esv2722374 CNV Deletion 23290073
nsv833966 CNV Gain+Loss 17160897
esv2722375 CNV Deletion 23290073
esv2665282 CNV Deletion 23128226
nsv521346 CNV Loss 19592680
nsv833967 CNV Loss 17160897

Variation tolerance for DLGAP4 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLGAP4 Gene

HapMap Linkage Disequilibrium report
DLGAP4
Human Gene Mutation Database (HGMD)
DLGAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP4 Gene

Disorders for DLGAP4 Gene

Relevant External Links for DLGAP4

Genetic Association Database (GAD)
DLGAP4
Human Genome Epidemiology (HuGE) Navigator
DLGAP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLGAP4

No disorders were found for DLGAP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLGAP4 Gene

Publications for DLGAP4 Gene

  1. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48 67
  2. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. (PMID: 9115257) Takeuchi M. … Takai Y. (J. Biol. Chem. 1997) 2 3
  3. Sequence and expression analysis of gaps in human chromosome 20. (PMID: 22510267) Minocherhomji S. … Silahtaroglu A. (Nucleic Acids Res. 2012) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for DLGAP4 Gene

Sources for DLGAP4 Gene

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