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DLGAP3 Gene

protein-coding   GIFtS: 50
GCID: GC01M035331

Discs, Large (Drosophila) Homolog-Associated Protein 3

  See DLGAP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Discs, Large (Drosophila) Homolog-Associated Protein 31 2     PSD-95/SAP90-Binding Protein 32 3
DAP-32 3     SAP90/PSD-95-Associated Protein 32 3
DAP32 3     Disks Large-Associated Protein 32
SAPAP32 3     SAP90/PSD 95 Associated Protein 32

External Ids:    HGNC: 303681   Entrez Gene: 585122   Ensembl: ENSG000001165447   OMIM: 6114135   UniProtKB: O958863   

Export aliases for DLGAP3 gene to outside databases

Previous GC identifers: GC01M034759 GC01M035000 GC01M035103 GC01M033448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DLGAP3 Gene:
DLGAP3 (discs, large (Drosophila) homolog-associated protein 3) is a protein-coding gene. Diseases associated with DLGAP3 include trichotillomania, and gilles de la tourette syndrome. GO annotations related to this gene include beta-amyloid binding. An important paralog of this gene is DLGAP4.

UniProtKB/Swiss-Prot: DLGP3_HUMAN, O95886
Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an
adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the
plasma membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DLGAP3 gene promoter:
         SREBP-1c   ATF-2   NRSF form 1   SREBP-1b   GATA-2   CRE-BP1   SREBP-1a   Zic1   COMP1   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLGAP3 promoter sequence
   Search Chromatin IP Primers for DLGAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLGAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3-p34.1   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p35.3-p34.1

DLGAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLGAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M035331:  view genomic region     (about GC identifiers)

Start:
35,331,037 bp from pter      End:
35,395,186 bp from pter
Size:
64,150 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DLGP3_HUMAN, O95886 (See protein sequence)
Recommended Name: Disks large-associated protein 3  
Size: 979 amino acids; 106040 Da
Subunit: Interacts with DLG4/PSD-95 (By similarity)
Sequence caution: Sequence=AAD20042.1; Type=Frameshift; Positions=833;
Secondary accessions: Q5TDD5 Q9H3X7

Explore the universe of human proteins at neXtProt for DLGAP3: NX_O95886

Explore proteomics data for DLGAP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DLGAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073887.1  
    ENSEMBL proteins: 
     ENSP00000362444   ENSP00000235180  

    DLGAP3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DLGAP3
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DLGAP3

     
    Search eBioscience for Proteins for DLGAP3 

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    EMD Millipore Mono- and Polyclonal Antibodies for the study of DLGAP3
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    LSBio Antibodies in human, mouse, rat for DLGAP3

    DLGAP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DLGAP3
    Cloud-Clone Corp. CLIAs for DLGAP3
    Search eBioscience for ELISAs for DLGAP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005026 GKAP

    Graphical View of Domain Structure for InterPro Entry O95886

    ProtoNet protein and cluster: O95886

    1 Blocks protein domain: IPB005026 Guanylate-kinase-associated protein

    UniProtKB/Swiss-Prot: DLGP3_HUMAN, O95886
    Similarity: Belongs to the SAPAP family


    Find genes that share domains with DLGAP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLGP3_HUMAN, O95886
    Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an
    adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the
    plasma membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IEA--
    GO:0005515protein binding IPI17474147
         
    Find genes that share ontologies with DLGAP3           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dlgap3):
     behavior/neurological  integument  nervous system 

    Find genes that share phenotypes with DLGAP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dlgap3tm1Gfng for DLGAP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLGAP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLGAP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLGAP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLGAP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DLGAP3:
    hsa-mir-324-5p (MIRT043117), hsa-mir-615-3p (MIRT040466), hsa-mir-106b-5p (MIRT044320), hsa-mir-16-5p (MIRT031739), hsa-mir-1296-5p (MIRT036140)

    Block miRNA regulation of human, mouse, rat DLGAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLGAP3 (see all 15):
    hsa-miR-148b* hsa-miR-100* hsa-miR-4271 hsa-miR-4318 hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-3175
    SwitchGear 3'UTR luciferase reporter plasmidDLGAP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLGAP3
    Predesigned siRNA for gene silencing in human, mouse, rat DLGAP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DLGAP3

    Clone
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    OriGene clones in human, mouse for DLGAP3 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: DLGAP3 (NM_001080418)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLGAP3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DLGAP3

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DLGAP3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLGAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLGP3_HUMAN, O95886: Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse,
    postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity).
    Note=Postsynaptic density of neuronal cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0045202synapse ----
    GO:0045211postsynaptic membrane IEA--

    Find genes that share ontologies with DLGAP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DLGAP3
        TRAIL Pathway
    all-trans-Retinoic Acid Mediated Apoptosis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DLGAP3
    Interactions:

        Search GeneGlobe Interaction Network for DLGAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for DLGAP3 (O958861, 2, 3 ENSP000002351804) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8111127 I2D: score=2 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111847 I2D: score=2 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112459 I2D: score=2 STRING: ENSP00000244007
    NCK1P163331, 3, ENSP000002889864EBI-1752541,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    SRCP129312, 3, ENSP000003509414MINT-8112999 I2D: score=2 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling IEA--

    Find genes that share ontologies with DLGAP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLGAP3 (DLGP3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DLGAP3 gene: 
    NM_001080418.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373347 ENST00000495979 ENST00000235180(uc001byc.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat DLGAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLGAP3 (see all 15):
    hsa-miR-148b* hsa-miR-100* hsa-miR-4271 hsa-miR-4318 hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-3175
    SwitchGear 3'UTR luciferase reporter plasmidDLGAP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DLGAP3
    Predesigned siRNA for gene silencing in human, mouse, rat DLGAP3
    Clone
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    OriGene clones in human, mouse for DLGAP3 (see all 7)
    OriGene ORF clones in mouse, rat for DLGAP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DLGAP3 (NM_001080418)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLGAP3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DLGAP3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DLGAP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLGAP3
      QuantiTect SYBR Green Assays in human, mouse, rat DLGAP3
      QuantiFast Probe-based Assays in human, mouse, rat DLGAP3

    Selected AceView cDNA sequences (see all 181):

    BM782513 BM904209 AA031564 AI423951 AI092684 BX345104 AA502345 CA443429 
    BQ434909 BF432512 CA432175 BX648912 BQ185112 BM551297 BQ070580 AL709970 
    CA454071 CD364570 AI553836 Z38718 AI559934 AI095804 BE540424 BM843300 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLGAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCCACTG
    DLGAP3 Expression
    About this image


    DLGAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
    DLGAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLGAP3 Protein Expression
        Custom PCR Arrays for DLGAP3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLGAP3
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    QuantiFast Probe-based Assays in human, mouse, rat DLGAP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLGAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLGAP3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlgap31 , 5 discs, large (Drosophila) homolog-associated protein more1, 5 92.38(n)1
    95.29(a)1
      4 (61.33 cM)5
    2426671  NM_198618.41  NP_941020.11 
     1271692045 
    chicken
    (Gallus gallus)
    Aves DLGAP31 discs, large (Drosophila) homolog-associated protein more 75.48(n)
    73.11(a)
      419638  XM_004947780.1  XP_004947837.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLGAP36
    discs, large (Drosophila) homolog-associated prote...
    61(a)
    1 ↔ 1
    GL343558.1(403335-449903)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dlgap31 discs, large homolog-associated protein 3 66.63(n)
    67(a)
      100127639  NM_001112987.1  NP_001106458.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dlgap31 discs, large (Drosophila) homolog-associated protein more 60.88(n)
    57.91(a)
      557556  NM_001044714.2  NP_001038179.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vlc6
    vulcan
    19(a)
    1 → many
    2R(1589605-1592944)


    ENSEMBL Gene Tree for DLGAP3 (if available)
    TreeFam Gene Tree for DLGAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLGAP3 gene
    DLGAP42  DLGAP12  DLGAP22  DLGAP52  
    3 SIMAP similar genes for DLGAP3 using alignment to 3 protein entries:     DLGP3_HUMAN (see all proteins):
    DLGAP2    DLGAP1    DLGAP4

    Find genes that share paralogs with DLGAP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLGAP3 (see all 789)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462931911,2
    C--35330630(+) ATTGTA/GCCCCT 1 -- ds50010--------
    rs1833883051,2
    C--35330692(+) GGTTTA/GTTGAG 1 -- ds50010--------
    rs1878516541,2
    C--35330801(+) AGCTTA/GGCACC 1 -- ds50010--------
    rs1924837371,2
    --35330811(+) CCTCCC/GCCTCT 1 -- ds50010--------
    rs1847152961,2
    --35330862(+) CTGTGA/GGCATC 1 -- ds50010--------
    rs1485113601,2
    C--35330947(+) CAAGAA/GAGTGG 1 -- ds50010--------
    rs118070601,2
    C,F,H--35331107(+) TGAGGG/AGAAGC 1 -- ut31 ese38Minor allele frequency- A:0.06NS NA WA 1178
    rs1143413071,2
    F--35331328(+) GGGGAG/TGGGGG 1 -- ut311Minor allele frequency- T:0.06WA 118
    rs1879893111,2
    --35331526(+) AAGGTA/GAAAAA 1 -- ut310--------
    rs1421239311,2
    F--35331708(+) TCGGGG/AATGTA 2 /I syn11Minor allele frequency- A:0.00NA 3624

    HapMap Linkage Disequilibrium report for DLGAP3 (35331037 - 35395186 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DLGAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670062CNV Deletion23128226

    Human Gene Mutation Database (HGMD): DLGAP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLGAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for DLGAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611413    OMIM disorders: --

    2 diseases for DLGAP3:    
    About MalaCards
    trichotillomania    gilles de la tourette syndrome

    2 diseases from the University of Copenhagen DISEASES database for DLGAP3:
    Trichotillomania     Gilles de la Tourette syndrome

    Find genes that share disorders with DLGAP3           About GenesLikeMe

    Genetic Association Database (GAD): DLGAP3
    Human Genome Epidemiology (HuGE) Navigator: DLGAP3 (5 documents)

    Export disorders for DLGAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLGAP3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with DLGAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study. (PubMed id 19051237)1, 4, 9 Bienvenu O.J....Nestadt G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    2. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    3. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    4. Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia. (PubMed id 23414653)1 Li J.M....Chen C.H. (Psychiatry Res 2013)
    5. Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation. (PubMed id 22761992)1 Chua J.J....Kindler S. (Sci Rep 2012)
    6. Interaction between genetic variants of DLGAP3 and SLC1A1 affecting the risk of atypical antipsychotics-induced obsessive-compulsive symptoms. (PubMed id 21990008)1 Ryu S....Hong K.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
    7. Family-based genetic association study of DLGAP3 in Tourette Syndrome. (PubMed id 21184590)1 Crane J....Scharf J.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
    8. Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population. (PubMed id 21295225)1 Boardman L....Hemmings S.M. (Compr Psychiatry 2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    10. Multiple rare SAPAP3 missense variants in trichotillomania and OCD. (PubMed id 19096451)1 ZA1chner S....Murphy D.L. (Mol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58512 HGNC: 30368 AceView: LOC113444 Ensembl:ENSG00000116544 euGenes: HUgn58512
    ECgene: DLGAP3 H-InvDB: DLGAP3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DLGAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for DLGAP3 gene:
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