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Aliases for DLGAP3 Gene

Aliases for DLGAP3 Gene

  • Discs, Large (Drosophila) Homolog-Associated Protein 3 2 3
  • SAP90/PSD-95-Associated Protein 3 3 4
  • PSD-95/SAP90-Binding Protein 3 3 4
  • SAPAP3 3 4
  • DAP-3 3 4
  • DAP3 3 4
  • SAP90/PSD 95 Associated Protein 3 3
  • Disks Large-Associated Protein 3 3

External Ids for DLGAP3 Gene

Summaries for DLGAP3 Gene

GeneCards Summary for DLGAP3 Gene

DLGAP3 (Discs, Large (Drosophila) Homolog-Associated Protein 3) is a Protein Coding gene. Diseases associated with DLGAP3 include trichotillomania and gilles de la tourette syndrome. Among its related pathways are FAS (CD95) signaling pathway and TWEAK Pathway. GO annotations related to this gene include beta-amyloid binding. An important paralog of this gene is DLGAP1.

UniProtKB/Swiss-Prot for DLGAP3 Gene

  • May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP3 Gene

Genomics for DLGAP3 Gene

Genomic Location for DLGAP3 Gene

Start:
34,865,436 bp from pter
End:
34,929,585 bp from pter
Size:
64,150 bases
Orientation:
Minus strand

Genomic View for DLGAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP3 Gene

Regulatory Elements for DLGAP3 Gene

Proteins for DLGAP3 Gene

  • Protein details for DLGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95886-DLGP3_HUMAN
    Recommended name:
    Disks large-associated protein 3
    Protein Accession:
    O95886
    Secondary Accessions:
    • Q5TDD5
    • Q9H3X7

    Protein attributes for DLGAP3 Gene

    Size:
    979 amino acids
    Molecular mass:
    106040 Da
    Quaternary structure:
    • Interacts with DLG4/PSD-95.
    SequenceCaution:
    • Sequence=AAD20042.1; Type=Frameshift; Positions=833; Evidence={ECO:0000305};

neXtProt entry for DLGAP3 Gene

Proteomics data for DLGAP3 Gene at MOPED

Post-translational modifications for DLGAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLGAP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLGAP3 Gene

Domains for DLGAP3 Gene

Protein Domains for DLGAP3 Gene

UniProtKB/Swiss-Prot:

DLGP3_HUMAN
Family:
  • Belongs to the SAPAP family.:
    • O95886
genes like me logo Genes that share domains with DLGAP3: view

No data available for Gene Families for DLGAP3 Gene

Function for DLGAP3 Gene

Molecular function for DLGAP3 Gene

UniProtKB/Swiss-Prot Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane

Gene Ontology (GO) - Molecular Function for DLGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IEA --
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with DLGAP3: view

Phenotypes for DLGAP3 Gene

genes like me logo Genes that share phenotypes with DLGAP3: view

Animal Models for DLGAP3 Gene

MGI Knock Outs for DLGAP3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DLGAP3 Gene

Localization for DLGAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP3 Gene

Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLGAP3 Gene COMPARTMENTS Subcellular localization image for DLGAP3 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for DLGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with DLGAP3: view

Pathways for DLGAP3 Gene

genes like me logo Genes that share pathways with DLGAP3: view

Pathways by source for DLGAP3 Gene

2 Qiagen pathways for DLGAP3 Gene
1 BioSystems pathway for DLGAP3 Gene

Gene Ontology (GO) - Biological Process for DLGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling --
GO:0023052 signaling IEA --
genes like me logo Genes that share ontologies with DLGAP3: view

Transcripts for DLGAP3 Gene

Unigene Clusters for DLGAP3 Gene

Discs, large (Drosophila) homolog-associated protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP3 Gene

No ASD Table

Relevant External Links for DLGAP3 Gene

GeneLoc Exon Structure for
DLGAP3
ECgene alternative splicing isoforms for
DLGAP3

Expression for DLGAP3 Gene

mRNA expression in normal human tissues for DLGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLGAP3 Gene

This gene is overexpressed in Brain - Cortex (5.6), Brain - Nucleus accumbens (basal ganglia) (5.4), Brain - Putamen (basal ganglia) (5.4), Brain - Hippocampus (5.0), Brain - Caudate (basal ganglia) (4.9), Brain - Frontal Cortex (BA9) (4.7), Brain - Anterior cingulate cortex (BA24) (4.7), and Brain - Amygdala (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DLGAP3 Gene

SOURCE GeneReport for Unigene cluster for DLGAP3 Gene Hs.733945

genes like me logo Genes that share expressions with DLGAP3: view

Orthologs for DLGAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLGAP3 36
  • 99.71 (n)
  • 99.87 (a)
DLGAP3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLGAP3 36
  • 94.11 (n)
  • 97.75 (a)
DLGAP3 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLGAP3 36
  • 93.18 (n)
  • 96.2 (a)
DLGAP3 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlgap3 36
  • 92.38 (n)
  • 95.29 (a)
Dlgap3 16
Dlgap3 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLGAP3 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLGAP3 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlgap3 36
  • 92.69 (n)
  • 95.39 (a)
chicken
(Gallus gallus)
Aves DLGAP3 36
  • 75.48 (n)
  • 73.11 (a)
SMIM12 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLGAP3 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlgap3 36
  • 66.63 (n)
  • 67 (a)
zebrafish
(Danio rerio)
Actinopterygii dlgap3 36
  • 60.88 (n)
  • 57.91 (a)
dlgap3 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vlc 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2669 37
  • 21 (a)
OneToMany
Species with no ortholog for DLGAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP3 Gene

ENSEMBL:
Gene Tree for DLGAP3 (if available)
TreeFam:
Gene Tree for DLGAP3 (if available)

Paralogs for DLGAP3 Gene

Paralogs for DLGAP3 Gene

Selected SIMAP similar genes for DLGAP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DLGAP3: view

Variants for DLGAP3 Gene

Sequence variations from dbSNP and Humsavar for DLGAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3587 -- 34,907,773(+) TACCA(C/T)AAGCA intron-variant
rs944920 -- 34,915,691(+) GTTCA(C/T)GTCGT intron-variant
rs1001616 -- 34,867,325(-) GTCCC(C/G)CTGTC intron-variant
rs1931058 -- 34,908,745(+) GAGGA(A/C)AAGGT intron-variant
rs1931059 -- 34,900,455(-) ATGAC(A/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP3 Gene

Variant ID Type Subtype PubMed ID
esv2670062 CNV Deletion 23128226

Relevant External Links for DLGAP3 Gene

HapMap Linkage Disequilibrium report
DLGAP3
Human Gene Mutation Database (HGMD)
DLGAP3

Disorders for DLGAP3 Gene

(2) University of Copenhagen DISEASES for DLGAP3 Gene

Relevant External Links for DLGAP3

Genetic Association Database (GAD)
DLGAP3
Human Genome Epidemiology (HuGE) Navigator
DLGAP3
genes like me logo Genes that share disorders with DLGAP3: view

No data available for UniProtKB/Swiss-Prot for DLGAP3 Gene

Publications for DLGAP3 Gene

  1. Sapap3 and pathological grooming in humans: Results from the OCD collaborative genetics study. (PMID: 19051237) Bienvenu O.J. … Nestadt G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 49
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. (PMID: 9115257) Takeuchi M. … Takai Y. (J. Biol. Chem. 1997) 3
  5. Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. (PMID: 10527873) Boeckers T.M. … Gundelfinger E.D. (Biochem. Biophys. Res. Commun. 1999) 3

Products for DLGAP3 Gene

  • antibodies-online peptides for DLGAP3
  • antibodies-online antibodies for DLGAP3
  • antibodies-online kits for DLGAP3

Sources for DLGAP3 Gene

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