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DLGAP2 Gene

protein-coding   GIFtS: 54
GCID: GC08P001436

Discs, Large (Drosophila) Homolog-Associated Protein 2

(Previous names: discs, large (Drosophila) homolog-associated protein 2)
  Search for DLGAP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Discs, Large (Drosophila) Homolog-Associated Protein 21 2     SAP90/PSD-95-Associated Protein 22 3
DAP22 3 5     Disks Large-Associated Protein 22
SAPAP22 3     DAP-23
PSD-95/SAP90-Binding Protein 22 3     

External Ids:    HGNC: 29061   Entrez Gene: 92282   Ensembl: ENSG000001980107   OMIM: 6054385   UniProtKB: Q9P1A63   

Export aliases for DLGAP2 gene to outside databases

Previous GC identifers: GC08P001260 GC08P001555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLGAP2 Gene:
The product of this gene is a membrane-associated guanylate kinase. The encoded protein may play a role in synapse
organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only
the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants
encoding different isoforms have been identified. (provided by RefSeq, Mar 2013)

GeneCards Summary for DLGAP2 Gene:
DLGAP2 (discs, large (Drosophila) homolog-associated protein 2) is a protein-coding gene. An important paralog of this gene is DLGAP4.

UniProtKB/Swiss-Prot: DLGP2_HUMAN, Q9P1A6
Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an
adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the
plasma membrane

Gene Wiki entry for DLGAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_023736.18  NC_018919.2  NT_187565.1  NT_187654.1  NT_187680.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLGAP2 gene promoter:
         Elk-1   AML1a   GATA-1   HNF-1A   C/EBPalpha   PPAR-gamma1   S8   HNF-1   Cart-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLGAP2 promoter sequence
   Search Chromatin IP Primers for DLGAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLGAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23   Ensembl cytogenetic band:  8p23.3   HGNC cytogenetic band: 8p23

DLGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLGAP2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P001436:  view genomic region     (about GC identifiers)

Start:
1,449,532 bp from pter      End:
1,656,642 bp from pter
Size:
207,111 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DLGP2_HUMAN, Q9P1A6 (See protein sequence)
Recommended Name: Disks large-associated protein 2  
Size: 1054 amino acids; 117620 Da
Subunit: Interacts with DLG1 and DLG4/PSD-95 (By similarity)
Sequence caution: Sequence=EAW51475.1; Type=Erroneous gene model prediction;
Secondary accessions: A1QCF8 A1QCF9 A5D8Y2 O14488 O14664 Q9P1A7
Alternative splicing: 3 isoforms:  Q9P1A6-1   Q9P1A6-2   Q9P1A6-3   

Explore the universe of human proteins at neXtProt for DLGAP2: NX_Q9P1A6

Explore proteomics data for DLGAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DLGAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001264090.1  NP_004736.2  

    ENSEMBL proteins: 
     ENSP00000400258   ENSP00000430563  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005026 GKAP

    Graphical View of Domain Structure for InterPro Entry Q9P1A6

    ProtoNet protein and cluster: Q9P1A6

    1 Blocks protein domain: IPB005026 Guanylate-kinase-associated protein

    UniProtKB/Swiss-Prot: DLGP2_HUMAN, Q9P1A6
    Similarity: Belongs to the SAPAP family


    Find genes that share domains with DLGAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLGP2_HUMAN, Q9P1A6
    Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an
    adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the
    plasma membrane

         Genatlas biochemistry entry for DLGAP2:
    Drosophila discslarge homolog-associated protein 2,binding the guanylate kinase-like domains of
    DLG2,DLG4,localized at postsynaptic density (PSD) in neuronal cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
         
    Find genes that share ontologies with DLGAP2           About GenesLikeMe


    Animal Models:
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    hsa-miR-1321 hsa-miR-106a hsa-miR-146a hsa-miR-3921 hsa-miR-3162-5p hsa-miR-502-3p hsa-miR-3622b-3p hsa-miR-637
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLGP2_HUMAN, Q9P1A6: Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse,
    postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity).
    Note=Postsynaptic density of neuronal cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus3
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005883neurofilament NAS10759891
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    Find genes that share ontologies with DLGAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DLGAP2
    Interactions:

        GeneGlobe Interaction Network for DLGAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DLGAP2 (Q9P1A61, 2, 3 ENSP000004002584) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8114525 I2D: score=2 STRING: ENSP00000361423
    PIK3R1P279862, 3, ENSP000002743354MINT-8111835 I2D: score=2 STRING: ENSP00000274335
    SRCP129312, 3, ENSP000003509414MINT-8112987 I2D: score=2 STRING: ENSP00000350941
    NCK1P163331, 3, ENSP000002889864EBI-1753397,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    GRB2P629931, 3, ENSP000003390074EBI-1753397,EBI-401755 I2D: score=2 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling ----
    GO:0007270neuron-neuron synaptic transmission NAS9694864

    Find genes that share ontologies with DLGAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLGAP2 (DLGP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DLGAP2 gene (2 alternative transcripts): 
    NM_001277161.1  NM_004745.4  

    Unigene Cluster for DLGAP2:

    Discs, large (Drosophila) homolog-associated protein 2
    Hs.113287  [show with all ESTs]
    Unigene Representative Sequence: AF119818
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421627(uc003wpl.3 uc003wpm.3) ENST00000520901 ENST00000522499
    ENST00000524065 ENST00000518530
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    hsa-miR-1321 hsa-miR-106a hsa-miR-146a hsa-miR-3921 hsa-miR-3162-5p hsa-miR-502-3p hsa-miR-3622b-3p hsa-miR-637
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      QuantiFast Probe-based Assays in human, mouse, rat DLGAP2

    Additional mRNA sequence: 

    AB000275.1 AF009204.1 AF119817.1 AF119818.1 BC141862.1 

    4 DOTS entries:

    DT.110719  DT.303800  DT.438271  DT.75124811 

    Selected AceView cDNA sequences (see all 43):

    AW275068 BX100279 F09956 AB000275 NM_004745 AA444121 AA994129 BX090471 
    AI025572 H49975 AI916873 AI480245 AA905334 AA928235 AF119818 BX493715 
    AA922186 BF059525 BG150231 AI017526 AF119817 AW119011 D82009 AF009204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLGAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGCCCC
    DLGAP2 Expression
    About this image

    DLGAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLGAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113287

    UniProtKB/Swiss-Prot: DLGP2_HUMAN, Q9P1A6
    Tissue specificity: Expressed in brain and kidney

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLGAP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlgap21 , 5 discs, large (Drosophila) homolog-associated protein more1, 5 82.52(n)1
    89.28(a)1
      8 (6.51 cM)5
    2443101  NM_172910.31  NP_766498.21 
     140958655 
    chicken
    (Gallus gallus)
    Aves DLGAP21 discs, large (Drosophila) homolog-associated protein more 78.38(n)
    88.74(a)
      421903  XM_004940487.1  XP_004940544.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLGAP26
    discs, large (Drosophila) homolog-associated prote...
    88(a)
    1 ↔ 1
    1(158852330-159000434)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dlgap21 discs, large (Drosophila) homolog-associated protein more 74.13(n)
    82.91(a)
      100489352  XM_002935149.2  XP_002935195.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dlgap21 discs, large (Drosophila) homolog-associated protein more 71.82(n)
    75.88(a)
      557621  XM_680713.5  XP_685805.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta vlc6
    vulcan
    22(a)
    1 → many
    2R(1589605-1592944)


    ENSEMBL Gene Tree for DLGAP2 (if available)
    TreeFam Gene Tree for DLGAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLGAP2 gene
    DLGAP42  DLGAP12  DLGAP32  DLGAP52  
    4 SIMAP similar genes for DLGAP2 using alignment to 2 protein entries:     DLGP2_HUMAN (see all proteins):
    ERICH1-AS1    DLGAP3    DLGAP4    DLGAP1

    Find genes that share paralogs with DLGAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLGAP2 (see all 6688)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492116111,2
    --1447560(+) TTGTTG/TTAGTT 2 -- us2k10--------
    rs1829018801,2
    --1447564(+) TTTAGC/TTCATC 2 -- us2k10--------
    rs792290441,2
    F--1447597(+) CTGGAC/TGCTCT 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1154841461,2
    F--1447605(+) TCTGTT/CCTCAC 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs783424231,2
    F--1447617(+) TTACTC/AACACA 2 -- us2k11Minor allele frequency- A:0.10WA 118
    rs1434030231,2
    C--1447623(+) ACACAG/TATGAC 2 -- us2k10--------
    rs70160291,2
    C,F,H--1447628(+) TATGAC/TGATGG 2 -- us2k111Minor allele frequency- T:0.07NS EA NA WA 1196
    rs1875334011,2
    --1447651(+) CTGTAC/GTTAAT 2 -- us2k10--------
    rs1513355171,2
    --1447671(+) CCATCA/TTATTT 2 -- us2k10--------
    rs1904654721,2
    --1447768(+) GCAGCC/TTAAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DLGAP2 (1449532 - 1656642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DLGAP2 (see all 83):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660259CNV Deletion23128226
    esv2736301CNV Deletion23290073
    esv2736305CNV Deletion23290073
    esv2658434CNV Deletion23128226
    esv2677016CNV Deletion23128226
    esv2736276CNV Deletion23290073
    esv2410209CNV Deletion18987734
    esv2447133CNV Deletion19546169
    esv2736291CNV Deletion23290073
    esv2736268CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DLGAP2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605438    OMIM disorders: --


    Find genes that share disorders with DLGAP2           About GenesLikeMe

    Genetic Association Database (GAD): DLGAP2
    Human Genome Epidemiology (HuGE) Navigator: DLGAP2 (6 documents)

    Export disorders for DLGAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLGAP2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DLGAP2)
        Utopia: connect your pdf to the dynamic
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    1. Positional cloning and characterization of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation. (PubMed id 10854099)1, 2, 3 Ranta S.... Lehesjoki A.-E. (Eur. J. Hum. Genet. 2000)
    2. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. (PubMed id 9286858)1, 2, 3 Satoh K.... Akiyama T. (Genes Cells 1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Functional impact of global rare copy number variation in autism spectrum disorders. (PubMed id 20531469)1, 4 Pinto D....Betancur C. (Nature 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)1, 4 Guilmatre A....Campion D. (Arch. Gen. Psychiatry 2009)
    7. Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study. (PubMed id 23154099)1 Wu K....Arnold P.D. (Psychiatry Res 2013)
    8. Genome-wide association study of age at menarche in African-American women. (PubMed id 23599027)1 Demerath E.W....Haiman C.A. (Hum. Mol. Genet. 2013)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. Computational and experimental identification of novel human imprinted genes. (PubMed id 18055845)1 Luedi P.P....Hartemink A.J. (Genome Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9228 HGNC: 2906 AceView: DLGAP2 Ensembl:ENSG00000198010 euGenes: HUgn9228
    ECgene: DLGAP2 H-InvDB: DLGAP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DLGAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DLGAP2 gene:
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    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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