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Aliases for DLGAP2 Gene

Aliases for DLGAP2 Gene

  • DLG Associated Protein 2 2 3 5
  • Discs Large Homolog Associated Protein 2 2 3
  • SAP90/PSD-95-Associated Protein 2 3 4
  • PSD-95/SAP90-Binding Protein 2 3 4
  • SAPAP2 3 4
  • DAP2 3 4
  • Discs, Large (Drosophila) Homolog-Associated Protein 2 2
  • Discs Large-Associated Protein 2 3
  • Disks Large-Associated Protein 2 3
  • DAP-2 4

External Ids for DLGAP2 Gene

Previous GeneCards Identifiers for DLGAP2 Gene

  • GC08P001260
  • GC08P001555
  • GC08P001436
  • GC08P000927

Summaries for DLGAP2 Gene

Entrez Gene Summary for DLGAP2 Gene

  • The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]

GeneCards Summary for DLGAP2 Gene

DLGAP2 (DLG Associated Protein 2) is a Protein Coding gene. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. An important paralog of this gene is DLGAP1.

UniProtKB/Swiss-Prot for DLGAP2 Gene

  • May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

Gene Wiki entry for DLGAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP2 Gene

Genomics for DLGAP2 Gene

Regulatory Elements for DLGAP2 Gene

Enhancers for DLGAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F001437 0.9 FANTOM5 ENCODE 11.4 +701.1 701139 1.6 RFX1 RNF2 TAL1 BMI1 ELF1 CBX8 ATF3 NFE2 DLGAP2 ERICH1-AS1 LOC105377775 DLGAP2-AS1
GH08F001372 0.6 ENCODE 10.7 +635.7 635692 0.8 PKNOX1 L3MBTL2 NRF1 BHLHE40 MNT ZFHX2 HMGN3 E2F6 EGR2 DLGAP2 ERICH1-AS1 LOC105377776 ENSG00000282160
GH08F001374 0.6 ENCODE 10.7 +636.9 636884 0.2 CEBPA CEBPB CEBPG NR2F6 MNT DLGAP2 ERICH1-AS1 ENSG00000281961 ENSG00000282160
GH08F001233 0.4 ENCODE 15.7 +495.8 495840 0.2 SMARCA4 DLGAP2 ERICH1-AS1 ENSG00000254160 GC08M001176
GH08F001478 0.5 ENCODE 12.2 +741.8 741780 2.3 POLR2A ZBED1 JUNB SPI1 DLGAP2 ERICH1-AS1 LOC105377775 DLGAP2-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DLGAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLGAP2 Gene

737,596 bp from pter
1,708,476 bp from pter
970,881 bases
Plus strand

Genomic View for DLGAP2 Gene

Genes around DLGAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLGAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP2 Gene

Proteins for DLGAP2 Gene

  • Protein details for DLGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disks large-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • A1QCF8
    • A1QCF9
    • A5D8Y2
    • O14488
    • O14664
    • Q9P1A7

    Protein attributes for DLGAP2 Gene

    1054 amino acids
    Molecular mass:
    117620 Da
    Quaternary structure:
    • Interacts with DLG1 and DLG4/PSD-95.
    • Sequence=EAW51475.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DLGAP2 Gene


neXtProt entry for DLGAP2 Gene

Post-translational modifications for DLGAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLGAP2 Gene

No data available for DME Specific Peptides for DLGAP2 Gene

Domains & Families for DLGAP2 Gene

Protein Domains for DLGAP2 Gene

Suggested Antigen Peptide Sequences for DLGAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAPAP family.
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP2: view

No data available for Gene Families for DLGAP2 Gene

Function for DLGAP2 Gene

Molecular function for DLGAP2 Gene

GENATLAS Biochemistry:
Drosophila discslarge homolog-associated protein 2,binding the guanylate kinase-like domains of DLG2,DLG4,localized at postsynaptic density (PSD) in neuronal cells
UniProtKB/Swiss-Prot Function:
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

Gene Ontology (GO) - Molecular Function for DLGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with DLGAP2: view
genes like me logo Genes that share phenotypes with DLGAP2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLGAP2 Gene

Localization for DLGAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP2 Gene

Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLGAP2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for DLGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005883 neurofilament NAS 10759891
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DLGAP2: view

Pathways & Interactions for DLGAP2 Gene

genes like me logo Genes that share pathways with DLGAP2: view

Pathways by source for DLGAP2 Gene

Gene Ontology (GO) - Biological Process for DLGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007270 neuron-neuron synaptic transmission IEA,NAS 9694864
GO:0023052 signaling IEA --
genes like me logo Genes that share ontologies with DLGAP2: view

No data available for SIGNOR curated interactions for DLGAP2 Gene

Transcripts for DLGAP2 Gene

Unigene Clusters for DLGAP2 Gene

Discs, large (Drosophila) homolog-associated protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP2 Gene

No ASD Table

Relevant External Links for DLGAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLGAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DLGAP2 Gene

mRNA differential expression in normal tissues according to GTEx for DLGAP2 Gene

This gene is overexpressed in Brain - Cortex (x7.6), Brain - Frontal Cortex (BA9) (x7.6), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Nucleus accumbens (basal ganglia) (x4.6), Brain - Putamen (basal ganglia) (x4.3), and Brain - Caudate (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for DLGAP2 Gene

This gene is overexpressed in Frontal cortex (61.4) and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DLGAP2 Gene

Protein tissue co-expression partners for DLGAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DLGAP2 Gene:


SOURCE GeneReport for Unigene cluster for DLGAP2 Gene:


mRNA Expression by UniProt/SwissProt for DLGAP2 Gene:

Tissue specificity: Expressed in brain and kidney.
genes like me logo Genes that share expression patterns with DLGAP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DLGAP2 Gene

Orthologs for DLGAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DLGAP2 35 34
  • 99.2 (n)
(Monodelphis domestica)
Mammalia DLGAP2 35
  • 86 (a)
(Canis familiaris)
Mammalia DLGAP2 34 35
  • 85.02 (n)
(Ornithorhynchus anatinus)
Mammalia DLGAP2 35
  • 85 (a)
(Bos Taurus)
Mammalia LOC100848239 34
  • 84.26 (n)
(Mus musculus)
Mammalia Dlgap2 34 16 35
  • 82.52 (n)
(Rattus norvegicus)
Mammalia Dlgap2 34
  • 82.45 (n)
(Gallus gallus)
Aves DLGAP2 34 35
  • 78.38 (n)
(Anolis carolinensis)
Reptilia DLGAP2 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dlgap2 34
  • 74.13 (n)
(Danio rerio)
Actinopterygii dlgap2 34
  • 71.82 (n)
DLGAP2 (2 of 3) 35
  • 71 (a)
dlgap2a 35
  • 65 (a)
dlgap2b 35
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta vlc 35
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2669 35
  • 25 (a)
Species where no ortholog for DLGAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP2 Gene

Gene Tree for DLGAP2 (if available)
Gene Tree for DLGAP2 (if available)

Paralogs for DLGAP2 Gene

Paralogs for DLGAP2 Gene

(4) SIMAP similar genes for DLGAP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLGAP2: view

Variants for DLGAP2 Gene

Sequence variations from dbSNP and Humsavar for DLGAP2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086219 -- 1,560,060(+) CTGTG(A/G)CTTTT intron-variant
rs10087292 -- 1,517,658(+) AGAAG(A/G)GCCTC intron-variant
rs10088143 -- 1,508,861(+) TCTCC(A/G)GAGGG intron-variant
rs10093186 -- 1,577,294(+) CTGGG(C/T)GCGGT intron-variant
rs10093266 -- 1,572,093(+) GGGGC(A/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP2 Gene

Variant ID Type Subtype PubMed ID
dgv11820n54 CNV gain 21841781
dgv11821n54 CNV loss 21841781
dgv6803n100 CNV gain 25217958
dgv6804n100 CNV gain 25217958
dgv6805n100 CNV gain+loss 25217958
dgv6806n100 CNV gain 25217958
esv1009105 CNV deletion 20482838
esv1148786 CNV deletion 17803354
esv1198504 CNV insertion 17803354
esv1240582 CNV deletion 17803354
esv1406551 CNV deletion 17803354
esv1567761 CNV deletion 17803354
esv2011197 CNV deletion 18987734
esv21666 CNV loss 19812545
esv2174611 CNV deletion 18987734
esv21755 CNV loss 19812545
esv2238262 CNV deletion 18987734
esv2410209 CNV deletion 18987734
esv2447133 CNV deletion 19546169
esv2487014 CNV deletion 19546169
esv2548579 CNV deletion 19546169
esv2549276 CNV deletion 19546169
esv26265 CNV gain 19812545
esv2658434 CNV deletion 23128226
esv2659022 CNV deletion 23128226
esv2660259 CNV deletion 23128226
esv2662501 CNV deletion 23128226
esv2667804 CNV deletion 23128226
esv2669614 CNV deletion 23128226
esv2677016 CNV deletion 23128226
esv2736268 CNV deletion 23290073
esv2736269 CNV deletion 23290073
esv2736270 CNV deletion 23290073
esv2736271 CNV deletion 23290073
esv2736272 CNV deletion 23290073
esv2736273 CNV deletion 23290073
esv2736275 CNV deletion 23290073
esv2736276 CNV deletion 23290073
esv2736277 CNV deletion 23290073
esv2736278 CNV deletion 23290073
esv2736279 CNV deletion 23290073
esv2736280 CNV deletion 23290073
esv2736281 CNV deletion 23290073
esv2736282 CNV deletion 23290073
esv2736283 CNV deletion 23290073
esv2736284 CNV deletion 23290073
esv2736286 CNV deletion 23290073
esv2736287 CNV deletion 23290073
esv2736288 CNV deletion 23290073
esv2736289 CNV deletion 23290073
esv2736290 CNV deletion 23290073
esv2736291 CNV deletion 23290073
esv2736292 CNV deletion 23290073
esv2736293 CNV deletion 23290073
esv2736294 CNV deletion 23290073
esv2736295 CNV deletion 23290073
esv2736297 CNV deletion 23290073
esv2736298 CNV deletion 23290073
esv2736299 CNV deletion 23290073
esv2736300 CNV deletion 23290073
esv2736301 CNV deletion 23290073
esv2736302 CNV deletion 23290073
esv2736303 CNV deletion 23290073
esv2736304 CNV deletion 23290073
esv2736305 CNV deletion 23290073
esv2736306 CNV deletion 23290073
esv2736308 CNV deletion 23290073
esv27484 CNV gain+loss 19812545
esv3542886 CNV deletion 23714750
esv3572384 CNV loss 25503493
esv3572385 CNV loss 25503493
esv3572386 CNV loss 25503493
esv3572388 CNV loss 25503493
esv3572389 CNV loss 25503493
esv3576504 CNV gain 25503493
esv3615837 CNV loss 21293372
esv3615838 CNV gain 21293372
esv3615839 CNV loss 21293372
esv3615840 CNV loss 21293372
esv3615841 CNV loss 21293372
esv3615842 CNV gain 21293372
esv988773 CNV deletion 20482838
nsv1019956 CNV gain 25217958
nsv1024325 CNV gain 25217958
nsv1026034 CNV gain+loss 25217958
nsv1029332 CNV loss 25217958
nsv1034963 CNV loss 25217958
nsv1075088 CNV deletion 25765185
nsv1076037 CNV deletion 25765185
nsv1076996 CNV deletion 25765185
nsv1076997 CNV deletion 25765185
nsv1115047 CNV deletion 24896259
nsv1119158 CNV deletion 24896259
nsv1128389 CNV deletion 24896259
nsv1128390 CNV deletion 24896259
nsv1132123 CNV deletion 24896259
nsv1135995 CNV deletion 24896259
nsv1146904 CNV deletion 26484159
nsv1151848 CNV deletion 26484159
nsv1153771 CNV deletion 26484159
nsv396012 CNV deletion 16902084
nsv397705 CNV deletion 16902084
nsv469881 CNV loss 16826518
nsv482921 CNV gain 15286789
nsv512018 CNV loss 21212237
nsv512019 CNV loss 21212237
nsv517779 CNV loss 19592680
nsv6045 CNV insertion 18451855
nsv609509 CNV gain 21841781
nsv609520 CNV loss 21841781
nsv821588 CNV deletion 20802225
nsv950273 CNV deletion 24416366
nsv950274 CNV deletion 24416366

Variation tolerance for DLGAP2 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLGAP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP2 Gene

Disorders for DLGAP2 Gene

Relevant External Links for DLGAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DLGAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLGAP2 Gene

Publications for DLGAP2 Gene

  1. Positional cloning and characterization of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation. (PMID: 10854099) Ranta S. … Lehesjoki A.-E. (Eur. J. Hum. Genet. 2000) 2 3 4 64
  2. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. (PMID: 9286858) Satoh K. … Akiyama T. (Genes Cells 1997) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Functional impact of global rare copy number variation in autism spectrum disorders. (PMID: 20531469) Pinto D. … Betancur C. (Nature 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for DLGAP2 Gene

Sources for DLGAP2 Gene

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