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Aliases for DLGAP1 Gene

Aliases for DLGAP1 Gene

  • DLG Associated Protein 1 2 3 5
  • Discs Large Homolog Associated Protein 1 2 3
  • Guanylate Kinase-Associated Protein 3 4
  • SAP90/PSD-95-Associated Protein 1 3 4
  • SAPAP1 3 4
  • DAP-1 3 4
  • DAP1 3 4
  • GKAP 3 4
  • Discs, Large (Drosophila) Homolog-Associated Protein 1 2
  • Disks Large-Associated Protein 1 3
  • PSD-95/SAP90 Binding Protein 1 3
  • PSD-95/SAP90-Binding Protein 1 4
  • DAP-1-ALPHA 3
  • DAP-1-BETA 3
  • DLGAP1A 3
  • DLGAP1B 3
  • HGKAP 4

External Ids for DLGAP1 Gene

Previous GeneCards Identifiers for DLGAP1 Gene

  • GC18P003654
  • GC18M003484

Summaries for DLGAP1 Gene

GeneCards Summary for DLGAP1 Gene

DLGAP1 (DLG Associated Protein 1) is a Protein Coding gene. Diseases associated with DLGAP1 include Obsessive-Compulsive Disorder. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. An important paralog of this gene is DLGAP2.

UniProtKB/Swiss-Prot for DLGAP1 Gene

  • Part of the postsynaptic scaffold in neuronal cells.

Gene Wiki entry for DLGAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP1 Gene

Genomics for DLGAP1 Gene

Regulatory Elements for DLGAP1 Gene

Enhancers for DLGAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F003816 1.5 FANTOM5 Ensembl ENCODE 15.6 +638.1 638076 2.3 BRCA1 RFX5 YY1 ZEB1 ZNF366 RCOR1 FOS SP3 CEBPB ZEB2 DLGAP1 TGIF1 GC18M003855 ENSG00000266513
GH18F003814 0.6 ENCODE 14.4 +640.3 640310 0.1 JUND JUN DLGAP1 ENSG00000266513 GC18M003855
GH18F004117 0.4 ENCODE 11.2 +335.9 335874 3.5 SOX5 CTCF SOX13 TEAD4 CEBPB RAD21 BCL11A POLR2A SMARCA4 CEBPA DLGAP1 GC18M003767 PIR39322
GH18F004124 0.6 Ensembl ENCODE 11.1 +329.9 329881 1.4 JUND SMARCA4 EBF1 MAFK DLGAP1 GC18M003767 GC18M004161
GH18F004182 0.6 ENCODE 11 +273.0 272960 0.2 SOX13 SOX5 CTCF NR2F6 CREM RAD21 DLGAP1 GC18M004161 DLGAP1-AS5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DLGAP1 on UCSC Golden Path with GeneCards custom track

Promoters for DLGAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DLGAP1 Gene

3,496,032 bp from pter
4,455,335 bp from pter
959,304 bases
Minus strand

Genomic View for DLGAP1 Gene

Genes around DLGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP1 Gene

Proteins for DLGAP1 Gene

  • Protein details for DLGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disks large-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • A8MWN8
    • B2RMU8
    • B7WPA1
    • B7Z2H2
    • B7Z2I2
    • B7Z9Y4
    • O14489
    • P78335

    Protein attributes for DLGAP1 Gene

    977 amino acids
    Molecular mass:
    108873 Da
    Quaternary structure:
    • Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1 (By similarity).

    Alternative splice isoforms for DLGAP1 Gene

neXtProt entry for DLGAP1 Gene

Post-translational modifications for DLGAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DLGAP1 (SAPAP1)
  • Abcam antibodies for DLGAP1
  • Santa Cruz Biotechnology (SCBT) Antibodies for DLGAP1

No data available for DME Specific Peptides for DLGAP1 Gene

Domains & Families for DLGAP1 Gene

Protein Domains for DLGAP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAPAP family.
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP1: view

No data available for Gene Families for DLGAP1 Gene

Function for DLGAP1 Gene

Molecular function for DLGAP1 Gene

GENATLAS Biochemistry:
Drosophila disc large homolog-associated protein 1,binding the guanylate kinase-like domain of DLG4,major constituans of the postsynaptic density (PSD) at the synaptic junction
UniProtKB/Swiss-Prot Function:
Part of the postsynaptic scaffold in neuronal cells.

Gene Ontology (GO) - Molecular Function for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with DLGAP1: view
genes like me logo Genes that share phenotypes with DLGAP1: view

Animal Model Products

miRNA for DLGAP1 Gene

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLGAP1 Gene

Localization for DLGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP1 Gene

Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for DLGAP1 Gene COMPARTMENTS Subcellular localization image for DLGAP1 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DLGAP1: view

Pathways & Interactions for DLGAP1 Gene

genes like me logo Genes that share pathways with DLGAP1: view

Pathways by source for DLGAP1 Gene

1 Cell Signaling Technology pathway for DLGAP1 Gene
1 KEGG pathway for DLGAP1 Gene

Gene Ontology (GO) - Biological Process for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA,NAS 9286858
GO:0023052 signaling IEA --
genes like me logo Genes that share ontologies with DLGAP1: view

No data available for SIGNOR curated interactions for DLGAP1 Gene

Drugs & Compounds for DLGAP1 Gene

(1) Drugs for DLGAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DLGAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLGAP1: view

Transcripts for DLGAP1 Gene

Unigene Clusters for DLGAP1 Gene

Discs, large (Drosophila) homolog-associated protein 1:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: -

Relevant External Links for DLGAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLGAP1 Gene

mRNA expression in normal human tissues for DLGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLGAP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.1), Brain - Anterior cingulate cortex (BA24) (x8.1), Brain - Cortex (x6.9), Brain - Cerebellar Hemisphere (x5.0), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for DLGAP1 Gene

This gene is overexpressed in Frontal cortex (40.1) and Brain (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DLGAP1 Gene

Protein tissue co-expression partners for DLGAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DLGAP1 Gene:


SOURCE GeneReport for Unigene cluster for DLGAP1 Gene:


mRNA Expression by UniProt/SwissProt for DLGAP1 Gene:

Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with DLGAP1: view

Primer Products

Orthologs for DLGAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DLGAP1 34 35
  • 99.68 (n)
(Canis familiaris)
Mammalia DLGAP1 34 35
  • 93.45 (n)
(Monodelphis domestica)
Mammalia DLGAP1 35
  • 93 (a)
(Bos Taurus)
Mammalia DLGAP1 34 35
  • 91.47 (n)
(Mus musculus)
Mammalia Dlgap1 34 16 35
  • 90.16 (n)
(Rattus norvegicus)
Mammalia Dlgap1 34
  • 89.92 (n)
(Ornithorhynchus anatinus)
Mammalia DLGAP1 35
  • 81 (a)
(Gallus gallus)
Aves -- 35
  • 93 (a)
-- 35
  • 89 (a)
LOC100859693 34
  • 79.46 (n)
(Anolis carolinensis)
Reptilia DLGAP1 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dlgap1 34
  • 72.25 (n)
(Danio rerio)
Actinopterygii dlgap1a 34 35
  • 72.42 (n)
dlgap1b 35
  • 67 (a)
otx5 34
fruit fly
(Drosophila melanogaster)
Insecta vlc 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2669 35
  • 25 (a)
Species where no ortholog for DLGAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP1 Gene

Gene Tree for DLGAP1 (if available)
Gene Tree for DLGAP1 (if available)

Paralogs for DLGAP1 Gene

Paralogs for DLGAP1 Gene

(3) SIMAP similar genes for DLGAP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLGAP1: view

Variants for DLGAP1 Gene

Sequence variations from dbSNP and Humsavar for DLGAP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000929 -- 4,005,122(-) GCGCT(A/G)AGAAC intron-variant, utr-variant-5-prime
rs10048343 -- 4,252,933(+) TCAAG(A/G)CACTT intron-variant
rs10048368 -- 4,253,242(+) ACTAA(A/C)CCCTT intron-variant
rs1006880 -- 4,269,650(-) ATGGC(C/T)GGGCG intron-variant
rs10083978 -- 3,974,112(+) ACTCC(C/G)TCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP1 Gene

Variant ID Type Subtype PubMed ID
dgv134e55 CNV gain 17911159
dgv1538n106 CNV deletion 24896259
dgv184n21 CNV gain 19592680
dgv3315n100 CNV gain 25217958
dgv3316n100 CNV loss 25217958
dgv52n6 CNV deletion 16902084
dgv540n67 CNV loss 20364138
dgv541n67 CNV loss 20364138
dgv577e199 CNV deletion 23128226
dgv578e199 CNV deletion 23128226
esv1053603 CNV deletion 17803354
esv1436100 CNV deletion 17803354
esv1587054 CNV deletion 17803354
esv1608190 CNV insertion 17803354
esv1733623 CNV deletion 17803354
esv2023494 CNV deletion 18987734
esv2166992 CNV deletion 18987734
esv22513 CNV loss 19812545
esv2282661 CNV deletion 18987734
esv2421665 CNV deletion 20811451
esv2432132 CNV deletion 19546169
esv2490559 CNV insertion 19546169
esv2559439 CNV insertion 19546169
esv2577067 CNV deletion 19546169
esv2637001 CNV deletion 19546169
esv2656305 CNV loss 23635498
esv2658035 CNV deletion 23128226
esv2660589 CNV deletion 23128226
esv2662406 CNV deletion 23128226
esv2662794 CNV deletion 23128226
esv2663849 CNV deletion 23128226
esv2663925 CNV deletion 23128226
esv2665888 CNV deletion 23128226
esv2667735 CNV deletion 23128226
esv2669815 CNV deletion 23128226
esv2673616 CNV deletion 23128226
esv2674074 CNV deletion 23128226
esv2674781 CNV deletion 23128226
esv2675505 CNV deletion 23128226
esv2676958 CNV deletion 23128226
esv2716689 CNV deletion 23290073
esv2716690 CNV deletion 23290073
esv2716691 CNV deletion 23290073
esv2716692 CNV deletion 23290073
esv2716693 CNV deletion 23290073
esv2716694 CNV deletion 23290073
esv2716697 CNV deletion 23290073
esv2716698 CNV deletion 23290073
esv2716699 CNV deletion 23290073
esv2716700 CNV deletion 23290073
esv2716701 CNV deletion 23290073
esv2716702 CNV deletion 23290073
esv2716703 CNV deletion 23290073
esv2716704 CNV deletion 23290073
esv2716705 CNV deletion 23290073
esv2758710 CNV gain 17122850
esv2760470 CNV loss 21179565
esv2762877 CNV loss 21179565
esv28168 CNV loss 19812545
esv29392 CNV loss 19812545
esv3144901 CNV deletion 24192839
esv3211494 CNV deletion 24192839
esv3211507 CNV deletion 24192839
esv3303118 CNV mobile element insertion 20981092
esv3345835 CNV insertion 20981092
esv3393114 CNV insertion 20981092
esv3415246 CNV insertion 20981092
esv3554971 CNV deletion 23714750
esv3554973 CNV deletion 23714750
esv3554974 CNV deletion 23714750
esv3554975 CNV deletion 23714750
esv3554976 CNV deletion 23714750
esv3582946 CNV loss 25503493
esv3582947 CNV loss 25503493
esv3641599 CNV loss 21293372
esv3641600 CNV loss 21293372
esv3641601 CNV loss 21293372
esv3641602 CNV loss 21293372
esv3641603 CNV loss 21293372
esv3641604 CNV loss 21293372
esv3641605 CNV loss 21293372
esv3641608 CNV loss 21293372
esv3641609 CNV loss 21293372
esv3641610 CNV loss 21293372
esv3641611 CNV gain 21293372
esv3641612 CNV loss 21293372
esv3641614 CNV loss 21293372
esv3641616 CNV loss 21293372
esv3641617 CNV loss 21293372
esv3641619 CNV loss 21293372
esv3641621 CNV loss 21293372
esv3641622 CNV loss 21293372
esv3641623 CNV loss 21293372
esv3641625 CNV loss 21293372
esv3893064 CNV loss 25118596
esv3893065 CNV gain 25118596
esv3893066 CNV gain 25118596
esv4964 CNV loss 18987735
esv5302 CNV loss 18987735
esv7766 CNV loss 19470904
nsv1059696 CNV gain 25217958
nsv1060485 CNV loss 25217958
nsv1061891 CNV gain 25217958
nsv1066089 CNV loss 25217958
nsv1071426 CNV deletion 25765185
nsv1071826 CNV deletion 25765185
nsv1072771 CNV deletion 25765185
nsv1113902 CNV deletion 24896259
nsv1116249 CNV deletion 24896259
nsv1116525 OTHER inversion 24896259
nsv1123154 CNV deletion 24896259
nsv1127611 CNV deletion 24896259
nsv1134691 CNV deletion 24896259
nsv1141944 OTHER inversion 24896259
nsv1142909 CNV tandem duplication 24896259
nsv1146733 CNV deletion 26484159
nsv131065 CNV deletion 16902084
nsv131453 CNV deletion 16902084
nsv131465 CNV deletion 16902084
nsv2191 CNV deletion 18451855
nsv438276 CNV loss 16468122
nsv458014 CNV loss 19166990
nsv458015 CNV loss 19166990
nsv510446 OTHER sequence alteration 20534489
nsv516032 CNV loss 19592680
nsv516152 CNV loss 19592680
nsv517765 CNV loss 19592680
nsv517856 CNV loss 19592680
nsv520546 CNV loss 19592680
nsv523068 CNV loss 19592680
nsv523341 CNV loss 19592680
nsv525905 CNV loss 19592680
nsv528429 CNV gain 19592680
nsv576316 CNV loss 21841781
nsv576317 CNV loss 21841781
nsv576318 CNV loss 21841781
nsv817779 CNV loss 17921354
nsv817780 CNV loss 17921354
nsv833582 CNV loss 17160897
nsv952402 CNV duplication 24416366
nsv954132 CNV deletion 24416366
nsv954143 CNV insertion 24416366
nsv954941 CNV deletion 24416366
nsv9601 CNV gain 18304495
nsv960245 CNV duplication 23825009
nsv960246 CNV duplication 23825009
nsv9603 CNV loss 18304495

Variation tolerance for DLGAP1 Gene

Residual Variation Intolerance Score: 1.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLGAP1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP1 Gene

Disorders for DLGAP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DLGAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DLGAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DLGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLGAP1 Gene

Publications for DLGAP1 Gene

  1. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. (PMID: 9024696) Kim E. … Sheng M. (J. Cell Biol. 1997) 2 3 4 22 64
  2. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. (PMID: 9286858) Satoh K. … Akiyama T. (Genes Cells 1997) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. (PMID: 15729360) Sabio G. … Cuenda A. (EMBO J. 2005) 3 22 64

Products for DLGAP1 Gene

Sources for DLGAP1 Gene

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