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Aliases for DLGAP1 Gene

Aliases for DLGAP1 Gene

  • Discs, Large (Drosophila) Homolog-Associated Protein 1 2 3
  • Guanylate Kinase-Associated Protein 3 4
  • SAP90/PSD-95-Associated Protein 1 3 4
  • SAPAP1 3 4
  • DAP-1 3 4
  • HGKAP 3 4
  • DAP1 3 4
  • GKAP 3 4
  • Disks Large-Associated Protein 1 3
  • PSD-95/SAP90 Binding Protein 1 3
  • PSD-95/SAP90-Binding Protein 1 4
  • DAP-1-ALPHA 3
  • DAP-1-BETA 3
  • DLGAP1A 3
  • DLGAP1B 3

External Ids for DLGAP1 Gene

Previous GeneCards Identifiers for DLGAP1 Gene

  • GC18P003654
  • GC18M003484

Summaries for DLGAP1 Gene

GeneCards Summary for DLGAP1 Gene

DLGAP1 (Discs, Large (Drosophila) Homolog-Associated Protein 1) is a Protein Coding gene. Among its related pathways are Circadian entrainment. An important paralog of this gene is DLGAP3.

UniProtKB/Swiss-Prot for DLGAP1 Gene

  • Part of the postsynaptic scaffold in neuronal cells

Gene Wiki entry for DLGAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP1 Gene

Genomics for DLGAP1 Gene

Regulatory Elements for DLGAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DLGAP1 Gene

Start:
3,496,032 bp from pter
End:
4,455,335 bp from pter
Size:
959,304 bases
Orientation:
Minus strand

Genomic View for DLGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP1 Gene

Proteins for DLGAP1 Gene

  • Protein details for DLGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14490-DLGP1_HUMAN
    Recommended name:
    Disks large-associated protein 1
    Protein Accession:
    O14490
    Secondary Accessions:
    • A8MWN8
    • B2RMU8
    • B7WPA1
    • B7Z2H2
    • B7Z2I2
    • B7Z9Y4
    • O14489
    • P78335

    Protein attributes for DLGAP1 Gene

    Size:
    977 amino acids
    Molecular mass:
    108873 Da
    Quaternary structure:
    • Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1 (By similarity).

    Alternative splice isoforms for DLGAP1 Gene

neXtProt entry for DLGAP1 Gene

Proteomics data for DLGAP1 Gene at MOPED

Post-translational modifications for DLGAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DLGAP1 (SAPAP1)

No data available for DME Specific Peptides for DLGAP1 Gene

Domains for DLGAP1 Gene

Protein Domains for DLGAP1 Gene

Graphical View of Domain Structure for InterPro Entry

O14490

UniProtKB/Swiss-Prot:

DLGP1_HUMAN :
  • O14490
Family:
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP1: view

No data available for Gene Families for DLGAP1 Gene

Function for DLGAP1 Gene

Molecular function for DLGAP1 Gene

GENATLAS Biochemistry: Drosophila disc large homolog-associated protein 1,binding the guanylate kinase-like domain of DLG4,major constituans of the postsynaptic density (PSD) at the synaptic junction
UniProtKB/Swiss-Prot Function: Part of the postsynaptic scaffold in neuronal cells

Gene Ontology (GO) - Molecular Function for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with DLGAP1: view

Phenotypes for DLGAP1 Gene

genes like me logo Genes that share phenotypes with DLGAP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLGAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DLGAP1 Gene

Localization for DLGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP1 Gene

Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLGAP1 Gene COMPARTMENTS Subcellular localization image for DLGAP1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0030054 cell junction IEA --
GO:0045202 synapse --
GO:0045211 postsynaptic membrane IEA --
GO:0097481 neuronal postsynaptic density IEA --
genes like me logo Genes that share ontologies with DLGAP1: view

Pathways for DLGAP1 Gene

SuperPathways for DLGAP1 Gene

Superpath Contained pathways
1 Circadian entrainment
genes like me logo Genes that share pathways with DLGAP1: view

Pathways by source for DLGAP1 Gene

1 KEGG pathway for DLGAP1 Gene

Gene Ontology (GO) - Biological Process for DLGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling --
GO:0007268 synaptic transmission NAS 9286858
genes like me logo Genes that share ontologies with DLGAP1: view

Compounds for DLGAP1 Gene

(3) Novoseek inferred chemical compound relationships for DLGAP1 Gene

Compound -log(P) Hits PubMed IDs
guanylate 77 16
nmda 53.6 7
glutamate 33.9 1
genes like me logo Genes that share compounds with DLGAP1: view

Transcripts for DLGAP1 Gene

Unigene Clusters for DLGAP1 Gene

Discs, large (Drosophila) homolog-associated protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLGAP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DLGAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6:
SP7:

Relevant External Links for DLGAP1 Gene

GeneLoc Exon Structure for
DLGAP1
ECgene alternative splicing isoforms for
DLGAP1

Expression for DLGAP1 Gene

mRNA expression in normal human tissues for DLGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLGAP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.1), Brain - Anterior cingulate cortex (BA24) (8.1), Brain - Cortex (6.9), Brain - Cerebellar Hemisphere (5.0), and Brain - Hippocampus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DLGAP1 Gene

SOURCE GeneReport for Unigene cluster for DLGAP1 Gene Hs.594640

mRNA Expression by UniProt/SwissProt for DLGAP1 Gene

O14490-DLGP1_HUMAN
Tissue specificity: Expressed in brain
genes like me logo Genes that share expressions with DLGAP1: view

In Situ Assay Products

Orthologs for DLGAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLGAP1 35
  • 99.68 (n)
  • 99.88 (a)
DLGAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLGAP1 35
  • 91.47 (n)
  • 97.34 (a)
DLGAP1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLGAP1 35
  • 93.45 (n)
  • 98.16 (a)
DLGAP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlgap1 35
  • 90.16 (n)
  • 96.11 (a)
Dlgap1 16
Dlgap1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLGAP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLGAP1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlgap1 35
  • 89.92 (n)
  • 96.11 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 93 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
LOC100859693 35
  • 79.46 (n)
  • 89.6 (a)
lizard
(Anolis carolinensis)
Reptilia DLGAP1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlgap1 35
  • 72.25 (n)
  • 80.9 (a)
zebrafish
(Danio rerio)
Actinopterygii dlgap1a 35
  • 72.42 (n)
  • 75.75 (a)
dlgap1a 36
  • 70 (a)
OneToMany
dlgap1b 36
  • 67 (a)
OneToMany
otx5 35
fruit fly
(Drosophila melanogaster)
Insecta vlc 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2669 36
  • 25 (a)
OneToMany
Species with no ortholog for DLGAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP1 Gene

ENSEMBL:
Gene Tree for DLGAP1 (if available)
TreeFam:
Gene Tree for DLGAP1 (if available)

Paralogs for DLGAP1 Gene

Paralogs for DLGAP1 Gene

Selected SIMAP similar genes for DLGAP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLGAP1: view

Variants for DLGAP1 Gene

Sequence variations from dbSNP and Humsavar for DLGAP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2137 -- 4,026,741(+) TAGTC(C/T)ATTCA intron-variant
rs2138 -- 4,026,802(+) CCTGG(A/G)AATAT intron-variant
rs4248 -- 4,026,708(+) TTTGG(A/T)CACAC intron-variant
rs103813 -- 3,712,187(-) CTGCA(C/T)TTCTC intron-variant
rs103814 -- 3,711,753(+) AGGCT(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP1 Gene

Variant ID Type Subtype PubMed ID
dgv52n6 CNV Loss 16902084
dgv577e199 CNV Deletion 23128226
esv2663925 CNV Deletion 23128226
dgv184n21 CNV Gain 19592680
esv2637001 CNV Deletion 19546169
esv2665888 CNV Deletion 23128226
esv22513 CNV Loss 19812545
esv2716689 CNV Deletion 23290073
esv2660589 CNV Deletion 23128226
dgv540n67 CNV Loss 20364138
nsv516032 CNV Loss 19592680
nsv817779 CNV Loss 17921354
nsv517856 CNV Loss 19592680
esv2490559 CNV Insertion 19546169
esv2559439 CNV Insertion 19546169
esv2673616 CNV Deletion 23128226
esv2716690 CNV Deletion 23290073
dgv578e199 CNV Deletion 23128226
dgv541n67 CNV Loss 20364138
esv2662406 CNV Deletion 23128226
esv29392 CNV Loss 19812545
esv2676958 CNV Deletion 23128226
esv267398 CNV Insertion 20981092
esv2716691 CNV Deletion 23290073
esv2716692 CNV Deletion 23290073
esv2716693 CNV Deletion 23290073
esv1053603 CNV Deletion 17803354
dgv1007e1 CNV Complex 17122850
nsv523341 CNV Loss 19592680
esv2674781 CNV Deletion 23128226
nsv458014 CNV Loss 19166990
nsv833582 CNV Loss 17160897
esv2669815 CNV Deletion 23128226
dgv134e55 CNV Gain 17911159
dgv1008e1 CNV Complex 17122850
esv2716694 CNV Deletion 23290073
nsv525905 CNV Loss 19592680
nsv438276 CNV Loss 16468122
esv2716697 CNV Deletion 23290073
esv2716698 CNV Deletion 23290073
esv2166992 CNV Deletion 18987734
nsv131465 CNV Loss 16902084
esv1733623 CNV Deletion 17803354
nsv2191 CNV Loss 18451855
nsv909318 CNV Gain 21882294
nsv9601 CNV Gain 18304495
esv2662794 CNV Deletion 23128226
esv2577067 CNV Deletion 19546169
esv2282661 CNV Deletion 18987734
esv4964 CNV Deletion 18987735
esv2716699 CNV Deletion 23290073
esv2658035 CNV Deletion 23128226
esv7766 CNV Loss 19470904
esv2432132 CNV Deletion 19546169
esv1587054 CNV Deletion 17803354
nsv131065 CNV Loss 16902084
esv1608190 CNV Insertion 17803354
nsv9603 CNV Loss 18304495
esv2675505 CNV Deletion 23128226
esv2716700 CNV Deletion 23290073
nsv520546 CNV Loss 19592680
nsv909319 CNV Loss 21882294
nsv909320 CNV Gain 21882294
esv2667735 CNV Deletion 23128226
nsv131453 CNV Loss 16902084
nsv523068 CNV Loss 19592680
nsv510446 CNV Loss 20534489
esv2663849 CNV Deletion 23128226
nsv517765 CNV Loss 19592680
nsv516152 CNV Loss 19592680
nsv909321 CNV Loss 21882294
esv2716701 CNV Deletion 23290073
esv2023494 CNV Deletion 18987734
esv2716702 CNV Deletion 23290073
esv2716703 CNV Deletion 23290073
esv1436100 CNV Deletion 17803354
esv2674074 CNV Deletion 23128226
esv28168 CNV Loss 19812545
esv2421665 CNV Deletion 20811451
nsv458015 CNV Loss 19166990
nsv817780 CNV Loss 17921354
esv268835 CNV Insertion 20981092
esv272473 CNV Insertion 20981092
nsv909322 CNV Loss 21882294
nsv528429 CNV Gain 19592680
nsv909323 CNV Loss 21882294
esv2716704 CNV Deletion 23290073
esv2716705 CNV Deletion 23290073
esv5302 CNV Deletion 18987735

Relevant External Links for DLGAP1 Gene

HapMap Linkage Disequilibrium report
DLGAP1
Human Gene Mutation Database (HGMD)
DLGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP1 Gene

Disorders for DLGAP1 Gene

(1) University of Copenhagen DISEASES for DLGAP1 Gene

(1) Novoseek inferred disease relationships for DLGAP1 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 3.36 4

Relevant External Links for DLGAP1

Genetic Association Database (GAD)
DLGAP1
Human Genome Epidemiology (HuGE) Navigator
DLGAP1
genes like me logo Genes that share disorders with DLGAP1: view

No data available for UniProtKB/Swiss-Prot for DLGAP1 Gene

Publications for DLGAP1 Gene

  1. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. (PMID: 9024696) Kim E. … Sheng M. (J. Cell Biol. 1997) 2 3 4 23
  2. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. (PMID: 9286858) Satoh K. … Akiyama T. (Genes Cells 1997) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Intramolecular interactions regulate SAP97 binding to GKAP. (PMID: 11060025) Wu H. … Garner C.C. (EMBO J. 2000) 3 23

Products for DLGAP1 Gene

Sources for DLGAP1 Gene

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