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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLG5 Gene

protein-coding   GIFtS: 58
GCID: GC10M079550

Discs, Large Homolog 5 (Drosophila)

(Previous names: discs, large (Drosophila) homolog 5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Discs, Large Homolog 5 (Drosophila)1 2     LP-DLG2
PDLG2 3 5     P-DLG52
Discs Large Protein P-Dlg2 3     Discs Large Protein LP-DLG2
Placenta And Prostate DLG2 3     Disks Large Homolog 52
KIAA05833 5     Large Type Of P-DLG2
Discs, Large (Drosophila) Homolog 51     

External Ids:    HGNC: 29041   Entrez Gene: 92312   Ensembl: ENSG000001512087   OMIM: 6040905   UniProtKB: Q8TDM63   

Export aliases for DLG5 gene to outside databases

Previous GC identifers: GC10M078507 GC10M078760 GC10M079442 GC10M078895 GC10M079220 GC10M073546


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DLG5 Gene:
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated
guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate
kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites
of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and
interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the
transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure.
Alternative splice variants have been described but their biological nature has not been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DLG5 Gene: 
DLG5 (discs, large homolog 5 (Drosophila)) is a protein-coding gene. Diseases associated with DLG5 include papilledema, and sclerosing cholangitis. GO annotations related to this gene include receptor signaling complex scaffold activity and beta-catenin binding. An important paralog of this gene is TJP3.

UniProtKB/Swiss-Prot: DLG5_HUMAN, Q8TDM6
Function: May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in
the transmission of extracellular signals to the membrane and cytoskeleton

Gene Wiki entry for DLG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLG5 gene promoter:
         Tal-1   Meis-1b   Egr-4   E47   NF-AT4   Sox9   Meis-1a   Hlf   Ik-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DLG5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLG5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q22.3   HGNC cytogenetic band: 10q23

DLG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLG5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M079550:  view genomic region     (about GC identifiers)

Start:
79,550,549 bp from pter      End:
79,686,378 bp from pter
Size:
135,830 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DLG5_HUMAN, Q8TDM6 (See protein sequence)
Recommended Name: Disks large homolog 5  
Size: 1919 amino acids; 213868 Da
Subunit: Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary
complex
Subcellular location: Cell junction. Cell membrane; Peripheral membrane protein. Note=Localized at sites of
cell-cell contact
Sequence caution: Sequence=AAI17696.1; Type=Erroneous initiation; Sequence=BAA25509.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DLG5:
1UIT (3D)    
Secondary accessions: A6H8Y3 Q149N1 Q5T1H7 Q5T1H8 Q6DKG3 Q86WC0 Q8TDM7 Q9UE73 Q9Y4E3
Alternative splicing: 5 isoforms:  Q8TDM6-1   Q8TDM6-2   Q8TDM6-3   Q8TDM6-4   Q8TDM6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DLG5: NX_Q8TDM6

Explore proteomics data for DLG5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDM6

  • DLG5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DLG5 Protein Expression
    REFSEQ proteins: NP_004738.3  
    ENSEMBL proteins: 
     ENSP00000394797   ENSP00000361467   ENSP00000473298   ENSP00000361464  

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    Cloud-Clone Corp. Proteins for DLG5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm TAS9738934
    GO:0005886plasma membrane NAS--
    GO:0005913cell-cell adherens junction IEA--

    DLG5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR008144 Guanylate_kin
     IPR006907 DUF622
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR011029 DEATH-like_dom
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q8TDM6

    ProtoNet protein and cluster: Q8TDM6

    3 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB008144 Guanylate kinase
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: DLG5_HUMAN, Q8TDM6
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 4 PDZ (DHR) domains
    Similarity: Contains 1 SH3 domain


    DLG5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLG5_HUMAN, Q8TDM6
    Function: May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in
    the transmission of extracellular signals to the membrane and cytoskeleton

         Genatlas biochemistry entry for DLG5:
    Drosophila tumor suppressor gene,discs large 5,giant larvae homolog,expressed in placenta and in epithelial glands
    (prostate),interacting with p55 palmitoylated membrane protein and putatively involved in the maintenance of the
    structure of epithelial cell

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008013beta-catenin binding IDA12657639
    GO:0008092cytoskeletal protein binding IDA12657639
    GO:0030159receptor signaling complex scaffold activity NAS12353226
         
    DLG5 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dlg5):
     behavior/neurological  cellular  craniofacial  growth/size  homeostasis/metabolism 
     nervous system  renal/urinary system 

    DLG5 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/26 Interacting proteins for DLG5 (Q8TDM62, 3 ENSP000003614674) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SORBS3O605042, 3, ENSP000002401234MINT-17378 MINT-17377 I2D: score=3 STRING: ENSP00000240123
    PFN1P077372, 3, ENSP000002256554MINT-63427 I2D: score=5 STRING: ENSP00000225655
    BTBD10Q9BSF82, 3MINT-65326 I2D: score=5 
    CD81P600332, 3, ENSP000002636454MINT-63912 I2D: score=5 STRING: ENSP00000263645
    TERF1P542743, ENSP000002766034I2D: score=4 STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9738934
    GO:0008285negative regulation of cell proliferation TAS9738934
    GO:0016337cell-cell adhesion NAS12353226
    GO:0035556intracellular signal transduction NAS12353226
    GO:0042981regulation of apoptotic process IEA--

    DLG5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLG5

    Search CenterWatch for drugs/clinical trials and news about DLG5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DLG5 gene: 
    NM_004747.3  

    Unigene Cluster for DLG5:

    Discs, large homolog 5 (Drosophila)
    Hs.652690  [show with all ESTs]
    Unigene Representative Sequence: BC146794
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000424842(uc001jzi.3) ENST00000475613 ENST00000372391(uc001jzj.3 uc001jzk.3 uc009xru.1)
    ENST00000463362 ENST00000459739 ENST00000468332(uc001jzl.4) ENST00000489547
    ENST00000484525 ENST00000476354 ENST00000466198 ENST00000372388
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate DLG5 (see all 56):
    hsa-miR-548j hsa-miR-188-5p hsa-miR-1258 hsa-miR-25 hsa-miR-301a hsa-miR-30d hsa-miR-192 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidDLG5 3' UTR sequence
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    Additional mRNA sequence: 

    AB011155.2 AB091676.1 AK055172.1 AK314771.1 BC015053.2 BC030250.1 BC073996.1 BC086867.1 
    BC117695.2 BC146794.1 BX649131.1 U61843.1 

    24/25 DOTS entries (see all 25):

    DT.451967  DT.97759907  DT.97818646  DT.101959733  DT.100041958  DT.86846729  DT.100796572  DT.40116370 
    DT.91749142  DT.95198395  DT.91932817  DT.75148599  DT.92030642  DT.121279186  DT.121279241  DT.435304 
    DT.92442232  DT.92442234  DT.95108022  DT.95108045  DT.95220815  DT.100741522  DT.86856689  DT.91828285 

    24/345 AceView cDNA sequences (see all 345):

    BQ672187 AI934279 AA705671 AA368265 AI983440 AA158311 BF086291 AL707962 
    BQ959879 BC002915 AI950059 BF939185 AA601564 BQ068894 CA434974 BU944159 
    BU752575 BQ672064 AI184231 CD654046 AI888029 T32830 F13436 AW612684 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DLG5 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^
    SP1:        -                                   -                             -                 -                                                               
    SP2:        -                                                                 -                 -                                                               
    SP3:                                            -                             -                 -                                               -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ·
    SP1:  -           -     -                                                     -                             -                                   -               
    SP2:  -           -     -                                                     -                                                                                 
    SP3:  -           -     -                                                     -                             -                                   -               
    SP4:  -           -     -                                                     -     -                       -                                                   
    SP5:              -     -                                                     -                             -                                   -               


    ECgene alternative splicing isoforms for DLG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DLG5 Expression
    About this image


    See DLG5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLG5

    SOURCE GeneReport for Unigene cluster: Hs.652690

    UniProtKB/Swiss-Prot: DLG5_HUMAN, Q8TDM6
    Tissue specificity: Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid,
    spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice
    product shows more limited expression, being absent from at least the brain

        SABiosciences Expression via Pathway-Focused PCR Array including DLG5: 
              Adherens Junctions in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DLG5 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlg51 , 5 discs, large homolog 5 (Drosophila)1, 5 87.85(n)1
    92.18(a)1
      14 (14.26 cM)5
    712281  NM_001163513.11  NP_001156985.11 
     241339535 
    chicken
    (Gallus gallus)
    Aves DLG51 discs, large homolog 5 (Drosophila) 69.02(n)
    72.57(a)
      423728  XM_421604.2  XP_421604.2 
    lizard
    (Anolis carolinensis)
    Reptilia DLG56
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343196.1(5174514-5322659)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.128212 Xenopus laevis transcribed sequence with weak similarity more 74.95(n)    BJ073452.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dlg5a1 discs, large homolog 5a (Drosophila) 63.07(n)
    58.38(a)
      569065  NM_001145603.1  NP_001139075.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65093   -- 38(a)   32F2   --
    worm
    (Caenorhabditis elegans)
    Secernentea magu-41 Protein MAGU-4 41.32(n)
    30.36(a)
      177860  NM_069404.2  NP_501805.1 


    ENSEMBL Gene Tree for DLG5 (if available)
    TreeFam Gene Tree for DLG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLG5 gene
    TJP32  TJP22  TJP12  
    2 SIMAP similar genes for DLG5 using alignment to 3 protein entries:     DLG5_HUMAN (see all proteins):
    DKFZp761P0818    DLG4

    DLG5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3044 SNPs in DLG5 are shown (see all 3044)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs581163531,2
    C--73561002(+) ACCCC-/TGCCCC 1 -- int10--------
    rs1425058171,2
    C--73574617(+) TCTTA-/GGGGGA 1 -- int10--------
    rs114460861,2
    C--73587629(+) ACTCTA/-AATCA 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1136497871,2
    C--73587820(+) TCTGCGAGT/-  
            
    GAGTG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1452411101,2
    C--73589263(+) AACAT-/CACCAC
            
    CACCA
    1 -- cds10--------
    rs1114581321,2
    C--73610715(+) TAGGG-/AC    
       
    /ACAC
    ACACA
    1 -- int11CSA 2
    rs589087671,2
    C--73610729(+) CACAC-/AC    
       
    /ACAC
    GAGCT
    1 -- int10--------
    rs724776791,2
    C--73630169(+) GAAAG-/AGAAGGAG 1 -- int10--------
    rs594796951,2
    C--73630171(+) AAGAG-/AAGGAGCT 1 -- int10--------
    rs673825051,2
    C--73631764(+) GAAGG-/AAAAAA 1 -- int11Minor allele frequency- A:0.00CSA 2

    HapMap Linkage Disequilibrium report for DLG5 (79550549 - 79686378 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DLG5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738529CNV Deletion23290073
    esv27942CNV Loss19812545
    esv34173CNV Loss18971310
    esv34062CNV Loss18971310
    esv34251CNV Gain17911159
    nsv895735CNV Gain21882294
    nsv895734CNV Gain21882294
    dgv302e1CNV Complex17122850
    dgv303e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): DLG5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DLG5
    DNA2.0 Custom Variant and Variant Library Synthesis for DLG5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604090    OMIM disorders: --

    20/22 diseases for DLG5 (see all 22):    About MalaCards
    papilledema    sclerosing cholangitis    primary sclerosing cholangitis    cholangitis
    prostatitis    crohn's disease    primary biliary cirrhosis    inflammatory bowel disease
    dilated cardiomyopathy    ulcerative colitis    meningioma    alcoholism
    rheumatoid arthritis    pancreatic cancer    arthritis    colorectal cancer
    alzheimer's disease    pancreatitis    thyroiditis    leukemia

    2 diseases from the University of Copenhagen DISEASES database for DLG5:
    Crohn's disease     Ulcerative colitis

    DLG5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): DLG5
    Human Genome Epidemiology (HuGE) Navigator: DLG5 (40 documents)

    Export disorders for DLG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLG5 gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with DLG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55. (PubMed id 9738934)1, 2, 3, 9 Nakamura H.... Saya H. (1998)
    2. Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD. (PubMed id 16344053)1, 4, 9 Vermeire S....Rutgeerts P. (2005)
    3. Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. (PubMed id 16437728)1, 4, 9 Gazouli M....Anagnou N.P. (2005)
    4. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (2011)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Molecular reclassification of Crohn's disease by clus ter analysis of genetic variants. (PubMed id 20886065)1, 4 Cleynen I....Vermeire S. (2010)
    9. Genetic association of DLG5 R30Q with familial and sp oradic inflammatory bowel disease in men. (PubMed id 20037206)1, 4 Lin Z....Koltun W.A. (2009)
    10. Genetic Risk Profiling And Prediction Of Disease Course In Crohn'S Disease Patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9231 HGNC: 2904 AceView: DLG5 Ensembl:ENSG00000151208 euGenes: HUgn9231
    ECgene: DLG5 H-InvDB: DLG5

    (According to HUGE)
    About This Section
    HUGE: KIAA0583

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLG5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DLG5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DLG5 gene:
    Search GeneIP for patents involving DLG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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