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Aliases for DLG5 Gene

Aliases for DLG5 Gene

  • Discs, Large Homolog 5 (Drosophila) 2 3
  • PDLG 3 4 6
  • Discs Large Protein P-Dlg 3 4
  • Placenta And Prostate DLG 3 4
  • KIAA0583 4 6
  • Discs, Large (Drosophila) Homolog 5 2
  • Discs Large Protein LP-DLG 3
  • Disks Large Homolog 5 3
  • Large Type Of P-DLG 3
  • LP-DLG 3
  • P-DLG5 3

External Ids for DLG5 Gene

Summaries for DLG5 Gene

Entrez Gene Summary for DLG5 Gene

  • This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLG5 Gene

DLG5 (Discs, Large Homolog 5 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include beta-catenin binding and receptor signaling complex scaffold activity. An important paralog of this gene is TJP2.

UniProtKB/Swiss-Prot for DLG5 Gene

  • May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.

Gene Wiki entry for DLG5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLG5 Gene

Genomics for DLG5 Gene

Genomic Location for DLG5 Gene

77,790,791 bp from pter
77,926,590 bp from pter
135,800 bases
Minus strand

Genomic View for DLG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLG5 Gene

Regulatory Elements for DLG5 Gene

Proteins for DLG5 Gene

  • Protein details for DLG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disks large homolog 5
    Protein Accession:
    Secondary Accessions:
    • A6H8Y3
    • Q149N1
    • Q5T1H7
    • Q5T1H8
    • Q6DKG3
    • Q86WC0
    • Q8TDM7
    • Q9UE73
    • Q9Y4E3

    Protein attributes for DLG5 Gene

    1919 amino acids
    Molecular mass:
    213868 Da
    Quaternary structure:
    • Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex.
    • Sequence=AAI17696.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA25509.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DLG5 Gene

    Alternative splice isoforms for DLG5 Gene


neXtProt entry for DLG5 Gene

Proteomics data for DLG5 Gene at MOPED

Post-translational modifications for DLG5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLG5 Gene

Domains for DLG5 Gene

Suggested Antigen Peptide Sequences for DLG5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 guanylate kinase-like domain.:
    • Q8TDM6
  • Contains 4 PDZ (DHR) domains.:
    • Q8TDM6
  • Contains 1 SH3 domain.:
    • Q8TDM6
  • Belongs to the MAGUK family.:
    • Q8TDM6
genes like me logo Genes that share domains with DLG5: view

No data available for Gene Families for DLG5 Gene

Function for DLG5 Gene

Molecular function for DLG5 Gene

GENATLAS Biochemistry: Drosophila tumor suppressor gene,discs large 5,giant larvae homolog,expressed in placenta and in epithelial glands (prostate),interacting with p55 palmitoylated membrane protein and putatively involved in the maintenance of the structure of epithelial cell
UniProtKB/Swiss-Prot Function: May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.

Gene Ontology (GO) - Molecular Function for DLG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23624079
GO:0008013 beta-catenin binding IDA 12657639
GO:0008092 cytoskeletal protein binding IDA 12657639
GO:0030159 receptor signaling complex scaffold activity NAS 12353226
genes like me logo Genes that share ontologies with DLG5: view
genes like me logo Genes that share phenotypes with DLG5: view

miRNA for DLG5 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DLG5 Gene

Localization for DLG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLG5 Gene

Cell junction. Cell membrane; Peripheral membrane protein. Note=Localized at sites of cell-cell contact.

Subcellular locations from

Jensen Localization Image for DLG5 Gene COMPARTMENTS Subcellular localization image for DLG5 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DLG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9738934
GO:0005886 plasma membrane IEA --
GO:0005913 cell-cell adherens junction IEA --
genes like me logo Genes that share ontologies with DLG5: view

Pathways for DLG5 Gene

SuperPathways for DLG5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IEA --
GO:0007165 signal transduction TAS 9738934
GO:0008285 negative regulation of cell proliferation TAS 9738934
GO:0016337 single organismal cell-cell adhesion NAS 12353226
GO:0030859 polarized epithelial cell differentiation IEA --
genes like me logo Genes that share ontologies with DLG5: view

No data available for Pathways by source for DLG5 Gene

Transcripts for DLG5 Gene

Unigene Clusters for DLG5 Gene

Discs, large homolog 5 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLG5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^
SP1: - - - -
SP2: - - -
SP3: - - - - - -
SP7: -
SP9: - -
SP10: -

ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ·
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP11: -
SP12: -

Relevant External Links for DLG5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLG5 Gene

mRNA expression in normal human tissues for DLG5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLG5 Gene

SOURCE GeneReport for Unigene cluster for DLG5 Gene Hs.652690

mRNA Expression by UniProt/SwissProt for DLG5 Gene

Tissue specificity: Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.
genes like me logo Genes that share expressions with DLG5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DLG5 Gene

Orthologs for DLG5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLG5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DLG5 35
  • 99.13 (n)
  • 98.84 (a)
DLG5 36
  • 100 (a)
(Bos Taurus)
Mammalia DLG5 35
  • 90.35 (n)
  • 93.69 (a)
DLG5 36
  • 93 (a)
(Canis familiaris)
Mammalia DLG5 35
  • 90.5 (n)
  • 94.06 (a)
DLG5 36
  • 94 (a)
(Mus musculus)
Mammalia Dlg5 35
  • 87.85 (n)
  • 92.18 (a)
Dlg5 16
Dlg5 36
  • 92 (a)
(Monodelphis domestica)
Mammalia DLG5 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia DLG5 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Dlg5 35
  • 87.03 (n)
  • 91.18 (a)
(Gallus gallus)
Aves DLG5 35
  • 66.95 (n)
  • 69.51 (a)
DLG5 36
  • 70 (a)
(Anolis carolinensis)
Reptilia DLG5 36
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12821 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dlg5 35
  • 63.66 (n)
  • 64.38 (a)
Str.5310 35
(Danio rerio)
Actinopterygii dlg5a 35
  • 64.64 (n)
  • 60.87 (a)
dlg5a 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6509 36
  • 25 (a)
CG6509 37
  • 38 (a)
Species with no ortholog for DLG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLG5 Gene

Gene Tree for DLG5 (if available)
Gene Tree for DLG5 (if available)

Paralogs for DLG5 Gene

Paralogs for DLG5 Gene

Selected SIMAP similar genes for DLG5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DLG5: view

Variants for DLG5 Gene

Sequence variations from dbSNP and Humsavar for DLG5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs963 -- 77,790,894(+) CCTGT(C/T)TGTGC utr-variant-3-prime
rs964 -- 77,790,869(+) AAAAT(C/T)CCAGT utr-variant-3-prime
rs713139 -- 77,902,044(+) TCTCA(C/T)TCGCT intron-variant
rs752111 -- 77,922,351(-) TGGAG(C/T)CCCAT intron-variant
rs752112 -- 77,922,277(-) CAACT(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLG5 Gene

Variant ID Type Subtype PubMed ID
dgv302e1 CNV Complex 17122850
dgv303e1 CNV Complex 17122850
esv34251 CNV Gain 17911159
nsv895734 CNV Gain 21882294
nsv895735 CNV Gain 21882294
esv34173 CNV Loss 18971310
esv34062 CNV Loss 18971310
esv2738529 CNV Deletion 23290073
esv27942 CNV Loss 19812545

Relevant External Links for DLG5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLG5 Gene

Disorders for DLG5 Gene

(2) University of Copenhagen DISEASES for DLG5 Gene

Relevant External Links for DLG5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DLG5: view

No data available for UniProtKB/Swiss-Prot for DLG5 Gene

Publications for DLG5 Gene

  1. Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55. (PMID: 9738934) Nakamura H. … Saya H. (FEBS Lett. 1998) 2 3 4 23
  2. Association of organic cation transporter risk haplotype with perianal penetrating Crohn's disease but not with susceptibility to IBD. (PMID: 16344053) Vermeire S. … Rutgeerts P. (Gastroenterology 2005) 3 23 48
  3. Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. (PMID: 16437728) Gazouli M. … Anagnou N.P. (World J. Gastroenterol. 2005) 3 23 48
  4. The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction network. (PMID: 18335190) Friedrichs F. … Weiner J. (J. Mol. Med. 2008) 3 23
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for DLG5 Gene

Sources for DLG5 Gene

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