Aliases for DLG5 Gene
External Ids for DLG5 Gene
Previous GeneCards Identifiers for DLG5 Gene
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLG5 Gene
DLG5 (Discs, Large Homolog 5 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include beta-catenin binding and receptor signaling complex scaffold activity. An important paralog of this gene is TJP2.
UniProtKB/Swiss-Prot for DLG5 Gene
May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.