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DLG4 Gene

protein-coding   GIFtS: 66
GCID: GC17M007094

Discs, Large Homolog 4 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Discs, Large Homolog 4 (Drosophila)1 2     Discs Large Homolog 42
PSD952 3 5     Disks Large Homolog 42
SAP902 3 5     Post-Synaptic Density Protein 952
Postsynaptic Density Protein 952 3     Tax Interaction Protein 152
Synapse-Associated Protein 902 3     PSD-953
SAP-902 3     

External Ids:    HGNC: 29031   Entrez Gene: 17422   Ensembl: ENSG000001325357   OMIM: 6028875   UniProtKB: P783523   

Export aliases for DLG4 gene to outside databases

Previous GC identifers: GC17M007484 GC17M007822 GC17M007036 GC17M007293 GC17M007033 GC17M006984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLG4 Gene:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with
another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK
proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion
channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLG4 Gene:
DLG4 (discs, large homolog 4 (Drosophila)) is a protein-coding gene. Diseases associated with DLG4 include brain ischemia, and familial adenomatous polyposis. GO annotations related to this gene include ionotropic glutamate receptor binding and protein C-terminus binding. An important paralog of this gene is MPP7.

UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352
Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels.
Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4
changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3
acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of
ADR1B (By similarity)

Gene Wiki entry for DLG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLG4 gene promoter:
         AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLG4 promoter sequence
   Search Chromatin IP Primers for DLG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

DLG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLG4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007094:  view genomic region     (about GC identifiers)

Start:
7,093,209 bp from pter      End:
7,123,369 bp from pter
Size:
30,161 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352 (See protein sequence)
Recommended Name: Disks large homolog 4  
Size: 724 amino acids; 80495 Da
Subunit: Interacts through its PDZ domains with ANO2 and NETO1. Interacts through its first two PDZ domains with
GRIN2A, GRIN2B, GRIN2C, GRIN2D, ASIC3, certain splice forms of GRIN1, KCND2, CXADR, SYNGAP1, KCNA1, KCNA2, KCNA3,
KCNA4, ERBB4, LRRC4; LRRC4B and SEMA4C. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT.
Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. Interacts through
its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3. Interacts through its guanylate
kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN, SIPA1L1 and KIF13B. Isoform 2
interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with ADR1B, ANKS1B and
PRR7. May interact with HTR2A. Interacts with ADAM22, KLHL17 and LGI1. Interacts with FRMPD4 (via C-terminus).
Interacts with LRFN1, LRFN2 and LRFN4, but not with LRFN3 nor LRFN5. Interacts (via N-terminus tandem pair of PDZ
domains) with GPER1 (via C-terminus tail motif); the interaction is direct and induces the increase of GPER1
protein levels residing at the plasma membrane surface in a estradiol-independent manner. Interacts (via
N-terminus tandem pair of PDZ domains) with NOS1 (via N-terminus domain). Interacts with SHANK3
4 PDB 3D structures from and Proteopedia for DLG4:
1KEF (3D)        3I4W (3D)        3K82 (3D)        3ZRT (3D)    
Secondary accessions: B7Z1S1 G5E939 Q92941 Q9UKK8
Alternative splicing: 3 isoforms:  P78352-1   P78352-2   P78352-3   (Ref.3 (AAD56173) sequence is in conflict in position: 46:E->V)

Explore the universe of human proteins at neXtProt for DLG4: NX_P78352

Explore proteomics data for DLG4 at MOPED

Post-translational modifications: 

  • Palmitoylation of isoform 1 is required for targeting to postsynaptic density (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DLG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122299.1  NP_001356.1  

    ENSEMBL proteins: 
     ENSP00000382425   ENSP00000307471   ENSP00000382428   ENSP00000467897   ENSP00000460625  
     ENSP00000407918   ENSP00000388122   ENSP00000465720   ENSP00000465789  
    Reactome Protein details: P78352

    DLG4 Human Recombinant Protein Products:

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    OriGene Purified Protein for DLG4
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    Novus Biologicals DLG4 Proteins
    Novus Biologicals DLG4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DLG4

    DLG4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DLG4
    R&D Systems Antibodies for DLG4 (PSD-95)
    Cell Signaling Technology (CST) Antibodies for DLG4  (PSD-95)
    OriGene Antibodies for DLG4
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    Novus Biologicals DLG4 Antibodies
    Abcam antibodies for DLG4
    Cloud-Clone Corp. Antibodies for DLG4
    ThermoFisher Antibody for DLG4
    LSBio Antibodies in human, mouse, rat for DLG4

    DLG4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DLG4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DLG4
    Cloud-Clone Corp. CLIAs for DLG4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR016313 DLG1
     IPR001452 SH3_domain
     IPR019583 PDZ_assoc

    Graphical View of Domain Structure for InterPro Entry P78352

    ProtoNet protein and cluster: P78352

    3 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB008144 Guanylate kinase


    UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352
    Domain: The PDZ domain 3 mediates interaction with ADR1B
    Domain: The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to
    postsynaptic density
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 3 PDZ (DHR) domains
    Similarity: Contains 1 SH3 domain


    DLG4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLG4_HUMAN, P78352
    Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels.
    Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4
    changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3
    acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of
    ADR1B (By similarity)

         Genatlas biochemistry entry for DLG4:
    Drosophila tumor suppressor gene,discs large (Dlg) homolog 4,expressed in neuronal and nonneuronal tissues at
    postsynaptic sites,heterodimerizing with DLG2,recruited into the same NMDA receptor and Shaker-type potassium
    channel clusters

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005515protein binding IPI10433268
    GO:0008022protein C-terminus binding IPI7477295
    GO:0019903protein phosphatase binding ISS--
    GO:0030165PDZ domain binding ISS--
         
    DLG4 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for DLG4:
     Decreased telomerase activity  Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella-containin  Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Dlg4):
     adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  integument  mortality/aging  nervous system 
     other 

    DLG4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DLG4: Dlg4tm2.1Grnt Dlg4tm1Rlh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLG4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLG4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLG4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLG4

    miRNA
    Products:
        
    miRTarBase miRNAs that target DLG4:
    hsa-mir-10a-5p (MIRT047670), hsa-mir-375 (MIRT019881)

    Block miRNA regulation of human, mouse, rat DLG4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLG4 (see all 45):
    hsa-miR-3678-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-650 hsa-miR-298 hsa-miR-149 hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidDLG4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLG4
    Predesigned siRNA for gene silencing in human, mouse, rat DLG4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DLG4

    Clone
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    OriGene clones in human, mouse for DLG4 (see all 11)
    OriGene ORF clones in mouse, rat for DLG4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DLG4 (NM_001128827)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLG4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DLG4
    Browse ESI BIO Cell Lines and PureStem Progenitors for DLG4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLG4_HUMAN, P78352: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell
    membrane, postsynaptic density. Cell junction, synapse. Note=High levels in postsynaptic density of neurons in
    the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon
    hillocks of Purkinje cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    mitochondrion3
    cytosol2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005886plasma membrane TAS--
    GO:0008021synaptic vesicle ISS--
    GO:0008328colocalizes with ionotropic glutamate receptor complex ISS--

    DLG4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DLG4 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Ras activation uopn Ca2+ infux through NMDA receptor0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    CREB phosphorylation through the activation of Ras0.78
    CREB phosphorylation through the activation of CaMKII0.00
    2L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    NrCAM interactions0.00
    3Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4ADP signalling through P2Y purinoceptor 12
    Activation of Kainate Receptors upon glutamate binding0.68
    Ionotropic activity of Kainate Receptors0.00
    Activation of Ca-permeable Kainate Receptor0.35
    5Trafficking of AMPA receptors
    Trafficking of AMPA receptors1.00
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DLG4
        Huntington's Disease Pathway
    nNOS Signaling at Neuronal Synapses

    1 Cell Signaling Technology (CST) Pathway for DLG4
        Neuroscience

    2 BioSystems Pathways for DLG4
        Wnt Signaling Pathway NetPath
    ErbB4 signaling events

    Selected Reactome Pathways for DLG4 (see all 6)
        Ras activation uopn Ca2+ infux through NMDA receptor
    Unblocking of NMDA receptor, glutamate binding and activation
    Trafficking of AMPA receptors
    CREB phosphorylation through the activation of CaMKII
    NrCAM interactions


    4 Kegg Pathways  (Kegg details for DLG4):
        Hippo signaling pathway
    Glutamatergic synapse
    Huntington's disease
    Cocaine addiction


    DLG4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLG4: 
              Neurogenesis in human mouse rat
              GABA & Glutamate in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DLG4

    Selected Interacting proteins for DLG4 (P783521, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 398)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLGAP1O144901, 2, 3EBI-80389,EBI-1753207 MINT-8305247 MINT-8305449 MINT-8305316 MINT-8305335 MINT-8305353 I2D: score=9 
    GRIN2CQ149571, 2, 3EBI-80389,EBI-8285963 MINT-1900102 MINT-1900873 MINT-1901291 MINT-1901315 I2D: score=7 
    CRIPTQ9P0211, 2, 3EBI-80389,EBI-946968 MINT-1901542 MINT-1901071 MINT-1901612 MINT-1900589 I2D: score=4 
    GRIN2AQ128791, 2, 3EBI-80389,EBI-7249937 MINT-1900076 MINT-1901389 MINT-1900851 I2D: score=11 
    KCNA4P224591, 2, 3EBI-80389,EBI-631235 MINT-1901203 MINT-1900477 I2D: score=9 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001973adenosine receptor signaling pathway ----
    GO:0002091negative regulation of receptor internalization ISS--
    GO:0006461protein complex assembly IDA15496675
    GO:0007165signal transduction TAS10364559
    GO:0007204positive regulation of cytosolic calcium ion concentration ISS--

    DLG4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLG4

    2 DrugBank Compounds for DLG4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    GuanidineAminomethanamidine (see all 9)113-00-8target--17139284 17016423 10592235
    Guanosine-5'-Monophosphate-- 85-32-5target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for DLG4 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 84.5 262 14529713 (7), 18992785 (5), 17179037 (5), 9454832 (4) (see all 99)
    guanylate 76.8 43 9024696 (2), 11779506 (2), 8938729 (2), 9286858 (2) (see all 30)
    glutamate 73.3 68 11080203 (5), 10037761 (3), 11955437 (2), 12562952 (2) (see all 41)
    2-bromopalmitate 56.7 1 16421296 (1)
    kainate 53.9 14 11279111 (3), 12562952 (2), 12597860 (1), 14969737 (1) (see all 8)
    tyrosine 35.5 28 14529711 (2), 15854593 (2), 10748194 (2), 12810713 (2) (see all 13)
    calcium 29.1 21 10364559 (3), 18554934 (2), 16712498 (1), 16719808 (1) (see all 15)
    nitric oxide 24 21 10364559 (3), 19075115 (2), 18554934 (1), 19627650 (1) (see all 12)
    gaba 17.1 2 18512761 (1), 18006501 (1)
    potassium 16 13 9867876 (2), 17666528 (1), 17950729 (1), 9148889 (1) (see all 9)



    DLG4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for DLG4 gene (2 alternative transcripts): 
    NM_001128827.1  NM_001365.3  

    Unigene Cluster for DLG4:

    Discs, large homolog 4 (Drosophila)
    Hs.463928  [show with all ESTs]
    Unigene Representative Sequence: NM_001365
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489885 ENST00000399506 ENST00000302955(uc010vtn.2 uc010cly.3)
    ENST00000399510 ENST00000491753 ENST00000485100(uc002geu.3) ENST00000451807
    ENST00000447163 ENST00000486626 ENST00000493294

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DLG4 (see all 45):
    hsa-miR-3678-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-650 hsa-miR-298 hsa-miR-149 hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidDLG4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DLG4 (NM_001128827)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG4
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DLG4
      QuantiFast Probe-based Assays in human, mouse, rat DLG4

    Additional mRNA sequence: 

    AF028825.1 AK293835.1 AK296357.1 AK297346.1 AK299801.1 AK307804.1 AK308533.1 AK316096.1 
    BC030203.1 BC040533.1 BC136553.1 BC144237.1 U68138.1 U83192.1 

    9 DOTS entries:

    DT.100766018  DT.114521  DT.120902957  DT.95163657  DT.95163659  DT.99975597  DT.91923360  DT.40278494 
    DT.97799166 

    Selected AceView cDNA sequences (see all 138):

    CD678803 AA984270 AA326156 BE704195 BE704220 BM703005 AA322688 AI792325 
    AF028825 BM715229 F08587 AI124569 BI916837 BQ638544 BC040533 BM809028 
    BX410033 BE838860 F06823 BC030203 BX433059 F03047 T31200 BQ446716 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DLG4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                    -     -     -           -     -                                                     -                                                   
    SP2:                                -           -     -           -                                                                                             
    SP3:                                -                 -           -                                                                                             
    SP4:                                                              -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:              -                     


    ECgene alternative splicing isoforms for DLG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGGAAGGT
    DLG4 Expression
    About this image


    DLG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
     
     Neurons
             Mature S Cone Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Mature S Cone Cells Outer Nuclear Layer
    DLG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLG4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463928

    UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352
    Tissue specificity: Brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DLG4: 
              Neurogenesis in human mouse rat
              GABA & Glutamate in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLG4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlg41 , 5 discs, large homolog 4 (Drosophila)1, 5 93.16(n)1
    99.3(a)1
      11 (42.96 cM)5
    133851  NM_007864.31  NP_031890.11 
     700170855 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.319852 Xenopus laevis transcribed sequence with moderate similarity more 76.34(n)    BX851259.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dlg41 discs, large homolog 4 (Drosophila) 72.42(n)
    81.54(a)
      100000823  XM_001340911.5  XP_001340947.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta dlg13 establishment and/or maintenance of
    polarity of more
    52(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea dlg-13 guanylate kinase 42(a)   X(5514745-5519401)   --


    ENSEMBL Gene Tree for DLG4 (if available)
    TreeFam Gene Tree for DLG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLG4 gene
    MPP72  DLG32  MPP62  MPP52  DLG22  MPP22  MPP42  DLG12  
    CASK2  MPP12  MPP32  
    Selected SIMAP similar genes for DLG4 using alignment to 10 protein entries:     DLG4_HUMAN (see all proteins) (see all similar genes):
    DKFZp761P0818    DLG1    DLG3    DLG2    SNTB2    SYNJ2BP
    DVL2    DVL3    MPP4    DVL1    LIN7A    DFNB31
    TJP1    TJP2    MPDZ    PDZD2    INADL    PCLO

    DLG4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLG4 (see all 712)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399281541,2
    --7007226(+) GGGGG-/TGACGG 2 -- int10--------
    rs3723516761,2
    C--7007226(+) GGGGGG/TGACGG 2 -- int10--------
    rs116578891,2
    C,H--7081194(+) gaatcG/Acttga 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs116527531,2
    C,A,H--7081205(+) ACCAGG/CGTGGC 2 -- ds50015Minor allele frequency- C:0.49NA CSA EA 245
    rs557422931,2
    C--7081228(+) GAGCCA/GAGATC 2 -- ds50010--------
    rs1132041731,2
    C,F--7081233(+) GAGATC/TGAGCC 2 -- ds50012Minor allele frequency- T:0.50WA CSA 4
    rs1878411881,2
    --7081234(+) AGATCA/GAGCCA 2 -- ds50010--------
    rs1929530531,2
    --7081235(+) GATCGA/TGCCAC 2 -- ds50010--------
    rs1393009621,2
    --7081292(+) AAACAA/CAAAAA 2 -- ds50010--------
    rs2019717541,2
    C--7081298(+) AAAAA-/AAAAAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DLG4 (7093209 - 7123369 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DLG4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715599CNV Deletion23290073
    esv2715598CNV Deletion23290073
    esv2422288CNV Deletion17116639
    esv2665200CNV Deletion23128226
    nsv1962CNV Insertion18451855
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv457659CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602887    OMIM disorders: --

    15 diseases for DLG4:    
    About MalaCards
    brain ischemia    familial adenomatous polyposis    nicotine dependence    brain injury
    bipolar disorder    ischemia    schizophrenia    huntington's disease
    intellectual disability    alzheimer's disease    dementia    mental retardation
    cerebritis    neuronitis    hiv-1

    1 disease from the University of Copenhagen DISEASES database for DLG4:
    Brain ischemia

    DLG4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for DLG4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypofunction 52.1 1 17093888 (1)
    ischemic brain injury 42.1 1 19610093 (1)
    schizophrenia 38.4 22 17093888 (4), 20175224 (3), 18033238 (2), 16762023 (2) (see all 11)
    alzheimers disease 25.5 1 18424056 (1)
    familial adenomatous polyposis 19.8 2 9286858 (1), 11029657 (1)
    bipolar disorder 12.1 5 18033238 (2), 15054476 (1)
    tumors 0.498 4 17121805 (1), 17316619 (1), 19617690 (1), 8824809 (1)
    ischemia 0 4 15854593 (1), 17018532 (1), 18338255 (1)
    dysplasia 0 1 15030493 (1)
    epilepsy 0 2 15030493 (1)

    Genetic Association Database (GAD): DLG4
    Human Genome Epidemiology (HuGE) Navigator: DLG4 (10 documents)

    Export disorders for DLG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLG4 gene, integrated from 10 sources (see all 398):
    (articles sorted by number of sources associating them with DLG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. (PubMed id 9286702)1, 2, 3, 9 Stathakis D.G.... Bryant P.J. (Genomics 1997)
    2. Association study of polymorphisms in post-synaptic density protein 95 (PSD-95) with schizophrenia. (PubMed id 17093888)1, 4, 9 Tsai S.J....Liou Y.J. (J Neural Transm 2007)
    3. The PDZ1 domain of SAP90. Characterization of structure and binding. (PubMed id 11744724)1, 2, 9 Piserchio A.... Mierke D.F. (J. Biol. Chem. 2002)
    4. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PubMed id 10859302)1, 2, 9 Hanada T.... Chishti A.H. (J. Biol. Chem. 2000)
    5. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. (PubMed id 7477295)1, 2, 9 Kim E.... Sheng M. (Nature 1995)
    6. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1, 4 Dastani Z....Kathiresan S. (PLoS Genet. 2012)
    7. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. (PubMed id 20921115)1, 4 Nicodemus K.K....Weinberger D.R. (Arch. Gen. Psychiatry 2010)
    10. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. (PubMed id 19118189)1, 2 Lee H.W.... Kim E. (J. Neurosci. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1742 HGNC: 2903 AceView: DLG4 Ensembl:ENSG00000132535 euGenes: HUgn1742
    ECgene: DLG4 Kegg: 1742 H-InvDB: DLG4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DLG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DLG4 gene:
    Search GeneIP for patents involving DLG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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