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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLG4 Gene

protein-coding   GIFtS: 67
GCID: GC17M007033

discs, large homolog 4 (Drosophila)
 Explore 19 diseases affiliated with
DLG4 via
MalaCards
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 Human Malady Compendium 
Biological research products
for DLG4    

Aliases
for DLG4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Discs, Large Homolog 4 (Drosophila)1 2     Synapse-Associated Protein 902 3
PSD951 2 3 5     Discs Large Homolog 42
SAP901 2 3 5     Disks Large Homolog 42
SAP-901 2 3     Post-Synaptic Density Protein 952
PSD-951 3     Tax Interaction Protein 152
Postsynaptic Density Protein 952 3     

External Ids:    HGNC: 29031   Entrez Gene: 17422   Ensembl: ENSG000001325357   OMIM: 6028875   UniProtKB: P783523   

Export aliases for DLG4 gene to outside databases

Previous GC identifers: GC17M007484 GC17M007822 GC17M007036 GC17M007293 GC17M006984


Summaries
for DLG4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DLG4:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with
another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK
proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion
channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352
Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required
for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio
of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by
retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity)

Gene Wiki entry for DLG4


Genomic Views
for DLG4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLG4 gene promoter:
         AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DLG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DLG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

DLG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLG4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007033:  view genomic region     (about GC identifiers)

Start:
 7,093,209 bp from pter      End:
 7,123,369 bp from pter
Size:
 30,161 bases      Orientation:
 minus strand

Proteins
for DLG4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352 (See protein sequence)
Recommended Name: Disks large homolog 4  
Size: 724 amino acids; 80495 Da
Subunit: Interacts with ANKS1B, KLHL17 and PRR7 (By similarity). Interacts through its PDZ domains with NETO1.
Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ASIC3, certain splice forms of GRIN1,
KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of
CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3,
DLGAP4, MAP1A and BEGAIN. Interacts through its third PDZ domain with CRIPT (By similarity). Interacts through its
first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2,
KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts
through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the
first L27 domain of CASK. Interacts with LRFN1, LRFN2 and LRFN4. Interacts with ANO2, ADAM22 and LGI1 (By similarity).
Interacts with FRMPD4 (via C-terminus). Interacts (via PDZ1 and PDZ2 domains) with LRRC4; LRRC4B and SEMA4C. Interacts
(via guanylate kinase-like domain) with SIPA1L1 (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane,
postsynaptic density. Cell junction, synapse. Cell junction, synapse, synaptosome (By similarity). Note=High levels in
postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by
cerebellar basket cells on axon hillocks of Purkinje cells
4 PDB 3D structures from and Proteopedia for DLG4:
1KEF (3D)        3I4W (3D)        3K82 (3D)        3ZRT (3D)    
Secondary accessions: B7Z1S1 Q92941 Q9UKK8
Alternative splicing: 2 isoforms:  P78352-1   P78352-2   (Ref.3 (AAD56173) sequence is in conflict in position: 46:E->V)

Explore the universe of human proteins at neXtProt for DLG4: NX_P78352

Post-translational modifications:

  • Palmitoylation of isoform 1 is required for targeting to postsynaptic density (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78352

    • DLG4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122299.1  NP_001356.1  

    ENSEMBL proteins: 
     ENSP00000382425   ENSP00000307471   ENSP00000382428   ENSP00000467897   ENSP00000460625  
     ENSP00000407918   ENSP00000467542   ENSP00000388122   ENSP00000465720   ENSP00000465789  
     ENSP00000293813  
    Reactome Protein details: P78352
    Human Recombinant Protein Products: 
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    Novus Biologicals DLG4 Proteins
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    Uscn Proteins for DLG4

    Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0008021synaptic vesicle IEA--
    GO:0008328colocalizes with ionotropic glutamate receptor complex ISS--


    DLG4 for ontologies           About GeneDecksing



    DLG4 Antibody Products: 
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    Uscn ELISAs and CLIAs for DLG4

    Protein Domains /
    Families
    for DLG4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DLG4 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR001478 PDZ
     IPR016313 M-assoc_guanylate_kinase
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry P78352

    ProtoNet protein and cluster: P78352

    3 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB008144 Guanylate kinase


    UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352
    Domain: The PDZ domain 3 mediates interaction with ADR1B
    Domain: The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic
    density
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 3 PDZ (DHR) domains
    Similarity: Contains 1 SH3 domain


    Function
    for DLG4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352
    Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required
    for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio
    of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by
    retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity)

         Genatlas biochemistry entry for DLG4:
    Drosophila tumor suppressor gene,discs large (Dlg) homolog 4,expressed in neuronal and nonneuronal tissues at
    postsynaptic sites,heterodimerizing with DLG2,recruited into the same NMDA receptor and Shaker-type potassium channel
    clusters

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate DLG4 (see all 45):
    hsa-miR-3678-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-650 hsa-miR-298 hsa-miR-149 hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: DLG4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLG4 (see all 4)
    OriGene shRNA RFP: DLG4
    OriGene siRNA: DLG4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLG4

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005515protein binding IPI16767099
    GO:0008022protein C-terminus binding IPI7477295
    GO:0019903protein phosphatase binding IEA--
    GO:0030165PDZ domain binding IEA--


    DLG4 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for DLG4:
     Decreased telomerase activity  Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella-containin  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for DLG4: Dlg4tm2.1Grnt Dlg4tm1Rlh
         8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Dlg4):
     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     integument  mortality/aging  nervous system 

    DLG4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DLG4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1CREB phosphorylation through the activation of CaMKII
    		CREB phosphorylation through the activation of CaMKII1.00
    		Unblocking of NMDA receptor, glutamate binding and activation0.68
    		Ras activation uopn Ca2+ infux through NMDA receptor0.78
    2Post NMDA receptor activation events
    		Post NMDA receptor activation events1.00
    		CREB phosphorylation through the activation of Ras0.82
    		Activation of NMDA receptor upon glutamate binding and postsynaptic events0.89
    3Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    		Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    4Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    5G beta:gamma signalling through PLC beta
    		Activation of Kainate Receptors upon glutamate binding0.67
    		Ionotropic activity of Kainate Receptors0.00
    		Activation of Ca-permeable Kainate Receptor0.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for DLG4
        Cytoplasmic microtubules
    Calcium channels

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DLG4
        Huntington's Disease Pathway
    nNOS Signaling at Neuronal Synapses

    1 Cell Signaling Technology (CST) Pathway for DLG4
        Neuroscience

    2 BioSystems Pathways for DLG4 
        Wnt Signaling Pathway NetPath
    ErbB4 signaling events

    5/18        Reactome Pathways for DLG4 (see all 18)
        L1CAM interactions
    Developmental Biology
    Unblocking of NMDA receptor, glutamate binding and activation
    Activation of Kainate Receptors upon glutamate binding
    Transmission across Chemical Synapses


    2         Kegg Pathways  (Kegg details for DLG4):
        Glutamatergic synapse
    Huntington's disease


    DLG4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/391 Interacting proteins for DLG4 (P783521, 2, 3 ENSP000002938134) via UniProtKB, MINT, STRING, and/or I2D (see all 391)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRIPTQ9P0212, 3, ENSP000002388924MINT-1901542 MINT-1901071 MINT-1901612 MINT-1900589 I2D: score=4 STRING: ENSP00000238892
    KCNA4P224592, 3, ENSP000003285114MINT-1901203 MINT-1900477 I2D: score=9 STRING: ENSP00000328511
    APPP050672, 3, ENSP000002849814MINT-7894154 MINT-7894116 I2D: score=2 STRING: ENSP00000284981
    GRIN2BQ132242, 3, ENSP000002795934MINT-1899852 MINT-1900667 I2D: score=11 STRING: ENSP00000279593
    GRIN2DO153992, 3, ENSP000002632694MINT-1901005 I2D: score=6 STRING: ENSP00000263269
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001973adenosine receptor signaling pathway ISS--
    GO:0002091negative regulation of receptor internalization IEA--
    GO:0006461protein complex assembly IDA15496675
    GO:0007165signal transduction TAS10364559
    GO:0007268synaptic transmission TAS--


    DLG4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DLG4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DLG4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DLG4

    2 DrugBank Compounds for DLG4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    GuanidineAminomethanamidine (see all 9)113-00-8target--17139284 17016423 10592235
    Guanosine-5'-Monophosphate-- 85-32-5target--17139284 17016423 10592235

    10/19 Novoseek chemical compound relationships for DLG4 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 84.5 262 14529713 (7), 18992785 (5), 17179037 (5), 9454832 (4) (see all 99)
    guanylate 76.8 43 9024696 (2), 11779506 (2), 8938729 (2), 9286858 (2) (see all 30)
    glutamate 73.3 68 11080203 (5), 10037761 (3), 11955437 (2), 12562952 (2) (see all 41)
    2-bromopalmitate 56.7 1 16421296 (1)
    kainate 53.9 14 11279111 (3), 12562952 (2), 12597860 (1), 14969737 (1) (see all 8)
    tyrosine 35.5 28 14529711 (2), 15854593 (2), 10748194 (2), 12810713 (2) (see all 13)
    calcium 29.1 21 10364559 (3), 18554934 (2), 16712498 (1), 16719808 (1) (see all 15)
    nitric oxide 24 21 10364559 (3), 19075115 (2), 18554934 (1), 19627650 (1) (see all 12)
    gaba 17.1 2 18512761 (1), 18006501 (1)
    potassium 16 13 9867876 (2), 17666528 (1), 17950729 (1), 9148889 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about DLG4 

    Transcripts
    for DLG4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for DLG4 gene (2 alternative transcripts): 
    NM_001128827.1  NM_001365.3  

    Unigene Cluster for DLG4:

    Discs, large homolog 4 (Drosophila)
    Hs.463928  [show with all ESTs]
    Unigene Representative Sequence: NM_001365
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489885 ENST00000399506 ENST00000302955(uc010vtn.2 uc010cly.3)
    ENST00000399510 ENST00000491753 ENST00000485100(uc002geu.3) ENST00000451807
    ENST00000471159 ENST00000447163 ENST00000486626 ENST00000493294 ENST00000293813(uc010vtm.2 uc002get.4 uc010vto.2)


    miRNA
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    hsa-miR-3678-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-650 hsa-miR-298 hsa-miR-149 hsa-miR-3613-3p hsa-miR-3148
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    Inhib. RNA
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    OriGene siRNA: DLG4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLG4
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF028825.1 AK293835.1 AK296357.1 AK297346.1 AK299801.1 AK307804.1 AK308533.1 AK316096.1 
    BC030203.1 BC040533.1 BC136553.1 BC144237.1 U68138.1 U83192.1 

    9 DOTS entries:

    DT.100766018  DT.114521  DT.120902957  DT.95163657  DT.95163659  DT.99975597  DT.91923360  DT.97799166 
    DT.40278494 

    24/138 AceView cDNA sequences (see all 138):

    BE704195 BM703005 AI792325 F08587 AI124569 AF028825 BI916837 BM715229 
    BE704220 BQ638544 AA984270 AA326156 CD678803 AA322688 BE704276 BE838865 
    CB852065 BX433060 AI571947 F03047 AW072027 AA326639 BX440129 AA323746 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DLG4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                    -     -     -           -     -                                                     -                                                   
    SP2:                                -           -     -           -                                                                                             
    SP3:                                -                 -           -                                                                                             
    SP4:                                                              -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22 ^ 23 ^ 24 ^ 25a · 25b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:              -                     


    ECgene alternative splicing isoforms for DLG4

    Expression
    for DLG4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DLG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTGGAAGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DLG4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature L Cone CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerMature M Cone CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerMature M-S Cone CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    EyeOuter Nuclear LayerMature S Cone CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

    See DLG4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DLG4

    SOURCE GeneReport for Unigene cluster: Hs.463928

    UniProtKB/Swiss-Prot: DLG4_HUMAN, P78352
    Tissue specificity: Brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including DLG4: 
              Neurogenesis in human mouse rat
              GABA & Glutamate in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    Orthologs
    for DLG4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DLG4 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DLG46
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL344541.1(22287-29554)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.319852 Xenopus laevis transcribed sequence with moderate similarity more 76.34(n)    BX851259.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dlg41 discs, large homolog 4 (Drosophila) 73.75(n)
    83.92(a)    		   100000823  XM_001340911.4  XP_001340947.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dlg13 establishment and/or maintenance of polarity
    of more    		 52(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea dlg-13 guanylate kinase 42(a)   X(5514745-5519401)   --


    ENSEMBL Gene Tree for DLG4 (if available)
    TreeFam Gene Tree for DLG4 (if available) 

    Paralogs
    for DLG4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DLG4 gene
    MPP62  MPP72  DLG32  MPP52  DLG22  MPP22  MPP42  DLG12  
    CASK2  MPP12  MPP32  
    18/54 SIMAP similar genes for DLG4 using alignment to 14 protein entries:     DLG4_HUMAN (see all proteins) (see all similar genes):
    DKFZp761P0818    DLG1    DLG3    SNTB2    DLG2    SYNJ2BP
    DVL2    DVL3    DVL1    LIN7A    DFNB31    TJP2
    TJP1    PDZD2    INADL    PCLO    PTPN13    USH1C

    DLG4 for paralogs           About GeneDecksing



    Genomic Variants
    for DLG4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/385 NCBI SNPs in DLG4 are shown (see all 385)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116578891,2
    		C,H--6984425(+) gaatcG/Acttga 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs557422931,2
    		--6984459(+) GAGCCA/GAGATC 2 -- ds50010--------
    rs1132041731,2
    		C,F,--6984464(+) GAGATC/TGAGCC 2 -- ds50012Minor allele frequency- T:0.50WA CSA 4
    rs797154801,2
    		C,--6984554(+) TCCTAG/CCTCTG 2 -- ds50013Minor allele frequency- C:0.06NA WA 240
    rs563880061,2
    		--6984983(+) AGCATC/TTCCAG 2 -- ut310--------
    rs1887761,2
    		C--6985242(-) TTTCCA/CCTTTT 2 -- ut311Minor allele frequency- C:0.00NA 2
    rs781600411,2
    		C,F,--6985899(+) AGGGGG/ATTGCA 2 -- int11Minor allele frequency- A:0.14WA 118
    rs620614291,2
    		--6986608(+) CTTCAC/TCCTTC 2 -- int11Minor allele frequency- T:0.50NA 2
    rs25865391,2
    		C,F,H,--6986791(-) CCTGAG/CGGGGA 2 -- int19Minor allele frequency- C:0.08NS EA NA 646
    rs25865381,2
    		H--6987152(-) TTCTTG/CACATC 2 -- int14Minor allele frequency- C:0.00NS EA 418

    HapMap Linkage Disequilibrium report for DLG4 (7093209 - 7123369 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DLG4: --

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    Disorders / Diseases
    for DLG4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DLG4 for disorders           About GeneDecksing

    OMIM gene information: 602887    OMIM disorders: --

    19 diseases for DLG4:    About MalaCards
    familial adenomatous polyposis    brain injury    nicotine dependence    intellectual disability
    bipolar disorder    polyposis    brain ischemia    alzheimer's disease
    ischemia    huntington's disease    schizophrenia    neurodegeneration
    dementia    lung carcinoma    cerebritis    cholesterol
    carcinoma    neuronitis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for DLG4:
    Brain ischemia

    10 Novoseek disease relationships for DLG4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypofunction 52.1 1 17093888 (1)
    ischemic brain injury 42.1 1 19610093 (1)
    schizophrenia 38.4 22 17093888 (4), 20175224 (3), 18033238 (2), 16762023 (2) (see all 11)
    alzheimers disease 25.5 1 18424056 (1)
    familial adenomatous polyposis 19.8 2 9286858 (1), 11029657 (1)
    bipolar disorder 12.1 5 18033238 (2), 15054476 (1)
    tumors 0.498 4 17121805 (1), 17316619 (1), 19617690 (1), 8824809 (1)
    ischemia 0 4 15854593 (1), 17018532 (1), 18338255 (1)
    dysplasia 0 1 15030493 (1)
    epilepsy 0 2 15030493 (1)

    Genetic Association Database (GAD): DLG4
    Human Genome Epidemiology (HuGE) Navigator: DLG4 (10 documents)

    Export disorders for DLG4 gene to outside databases

    Publications
    for DLG4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DLG4 gene, integrated from 9 sources (see all 392):
    (articles sorted by number of sources associating them with DLG4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. (PubMed id 9286702)1, 2, 3, 9 Stathakis D.G.... Bryant P.J. (1997)
    2. The PDZ1 domain of SAP90. Characterization of structure and binding. (PubMed id 11744724)1, 2, 9 Piserchio A....Mierke D.F. (2002)
    3. GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PubMed id 10859302)1, 2, 9 Hanada T.... Chishti A.H. (2000)
    4. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. (PubMed id 7477295)1, 2, 9 Kim E.... Sheng M. (1995)
    5. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. (PubMed id 19118189)1, 2 Lee H.W....Kim E. (2008)
    6. Mutation and association analysis of the DAP-1 gene with schizophrenia. (PubMed id 12950712)1, 4 Aoyama S....Maeda K. (2003)
    7. Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. (PubMed id 12151521)1, 2 Chetkovich D.M....Bredt D.S. (2002)
    8. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. (PubMed id 10725395)1, 2 Garcia R.A.... Buonanno A. (2000)
    9. Binding of neuroligins to PSD-95. (PubMed id 9278515)1, 2 Irie M.... Suedhof T.C. (1997)
    10. Overlapping gene structure of human VLCAD and DLG4. (PubMed id 12609736)1, 9 Zhou C. and Blumberg B. (2003)

    External Searches for DLG4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DLG4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1742 HGNC: 2903 AceView: DLG4 Ensembl:ENSG00000132535 euGenes: HUgn1742
    ECgene: DLG4 Kegg: 1742 H-InvDB: DLG4

    Other Databases showing DLG4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DLG4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DLG4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DLG4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DLG4 gene:
    Search GeneIP for patents involving DLG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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