Aliases for DLG4 Gene
External Ids for DLG4 Gene
Previous GeneCards Identifiers for DLG4 Gene
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DLG4 Gene
DLG4 (Discs Large MAGUK Scaffold Protein 4) is a Protein Coding gene. Diseases associated with DLG4 include Cerebral Degeneration and Huntington Disease. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Activation of NMDA receptor upon glutamate binding and postsynaptic events. GO annotations related to this gene include receptor binding and protein C-terminus binding. An important paralog of this gene is DLG1.
UniProtKB/Swiss-Prot for DLG4 Gene
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).