DLG3 Gene
protein-coding GIFtS: 63
GCID: GC0XP069664
|
|
discs, large homolog 3 (Drosophila)(Previous names: discs, large homolog 3 (neuroendocrine-dlg, Drosophila)...)
| |
Aliases
for DLG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Discs, Large Homolog 3 (Drosophila)1 2 | | XLMR2 3 | | SAP1021 2 3 5 | | NE-Dlg1 | | MRX901 2 5 | | Discs, Large Homolog 3 (Neuroendocrine-Dlg, Drosophila)1 | | NEDLG1 2 5 | | MRX2 | | KIAA12321 3 | | Disks Large Homolog 32 | | SAP-1021 3 | | Neuroendocrine-DLG3 | | Synapse-Associated Protein 1022 3 | | Neuroendocrine-DLG3 |
Export aliases for DLG3 gene to outside databasesPrevious GC identifers: GC0XP065842 GC0XP067142 GC0XP067897 GC0XP068531 GC0XP069447 GC0XP069581 GC0XP063486 |
Summaries
for DLG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DLG3:
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play arole in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferationthrough interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutationsin this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants havebeen described. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796Function: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling
Gene Wiki entry for DLG3
|
Genomic Views
for DLG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DLG3 gene promoter:
E2F-4 E2F-3a E2F-5 Spz1 IRF-1 E2F-2 E2F E2F-1 HOXA5
Other transcription factors
Search SABiosciences Chromatin IP Primers for DLG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1DLG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP069664: view genomic region
(about GC identifiers)
Start:
|
69,664,705 bp from pter |
End:
|
69,725,340 bp from pter |
Size:
|
60,636 bases |
Orientation:
|
plus strand |
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Proteins
for DLG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796 (See
protein sequence)Recommended Name: Disks large homolog 3 Size: 817 amino acids; 90314 Da
Subunit: Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-likedomain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts through its PDZ domains with APC. Interactsthrough its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably withNLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4
Sequence caution: Sequence=BAA86546.1; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for DLG3:1UM7 (3D)
2FE5 (3D)
2I1N (3D)
Secondary accessions: B4E0H1 D3DVU5 Q5JUW6 Q5JUW7 Q9ULI8Alternative splicing: 3 isoforms: Q92796-1 Q92796-2 Q92796-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DLG3: NX_Q92796
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92796
DLG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001159750.1 NP_065781.1 NP_066943.2
ENSEMBL proteins: ENSP00000194900 ENSP00000363480 ENSP00000363475 ENSP00000441393 Reactome Protein details: Q92796
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
DLG3 for ontologies About GeneDecksing
DLG3 Antibody Products:
Assay Products for DLG3: |
Protein
Domains /
Families
for DLG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DLG3 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q92796ProtoNet protein and cluster: Q92796 3 Blocks protein families: IPB001452 SH3 domain signature IPB001478 PDZ/DHR/GLGF domain IPB008144 Guanylate kinase
UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796Similarity: Belongs to the MAGUK familySimilarity: Contains 1 guanylate kinase-like domainSimilarity: Contains 3 PDZ (DHR) domainsSimilarity: Contains 1 SH3 domain |
Function
for DLG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796Function: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling Genatlas biochemistry entry for DLG3:Drosophila tumor suppressor gene,discs large (Dlg) homolog 3,100kDa,expressed in neuronal and endocrinetissues,putative negative regulator of cell proliferation,through its interaction with APC,critical for synaptogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLG3 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLG3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DLG3 (NM_020730) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DLG3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG3 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
DLG3 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Dlg3tm1Grnt for DLG3
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Dlg3):
DLG3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DLG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transmission across Chemical Synapses | | | 2 | Axon guidance | | | 3 | G beta:gamma signalling through PLC beta | | | 4 | Neuroscience | | | 5 | NrCAM interactions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DLG3
1 
Cell Signaling Technology (CST) Pathway for DLG3
5/10 
Reactome Pathways for DLG3 (see all 10)
DLG3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLG3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/105 Interacting proteins for DLG3 (Q927961, 2, 3 ENSP000003634804) via UniProtKB, MINT, STRING, and/or I2D (see all 105)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
DLG3 for ontologies About GeneDecksing
|
Drugs & Compounds
for DLG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DLG3 for compounds About GeneDecksing
 Browse Tocris compounds for DLG3
5 Novoseek chemical compound relationships for DLG3 gene About this table
Search CenterWatch for drugs/clinical trials and news about DLG3
|
Transcripts
for DLG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DLG3 gene (3 alternative transcripts): NM_001166278.1 NM_020730.2 NM_021120.3 Unigene Cluster for DLG3: Discs, large homolog 3 (Drosophila) Hs.721586 [show with all ESTs]Unigene Representative Sequence: NM_02112010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000194900(uc004dyi.2) ENST00000374360 ENST00000463252 ENST00000374355(uc004dyj.2)
ENST00000489733 ENST00000494493 ENST00000466140 ENST00000461646 ENST00000496931
ENST00000542398(uc011mpn.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLG3 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLG3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): DLG3 (NM_020730) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DLG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG3 |
Additional cDNA sequence: AB033058.1 AB209328.1 AK303377.1 AK304020.1 AK315041.1 AK316518.1 BC093864.1 BC093866.1 U49089.1 7 DOTS entries: DT.443957 DT.95274749 DT.100782358 DT.121281100 DT.91842833 DT.40216899 DT.91718296 24/179 AceView cDNA sequences (see all 179): BQ187175 AI272678 AW182851 AI628192 BU071042 BM313692 BQ232694 CK905157 T09193 BM976042 AB033058 BQ008470 BM828820 BM977747 AA765737 BU782687 AI628170 BM471650 AI628529 BU735993 BU186986 BU784486 BX282195 BQ933278
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DLG3 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25a | · | 25b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for DLG3
|
Expression
for DLG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DLG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DLG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DLG3
SOURCE GeneReport for Unigene cluster: Hs.721586
SABiosciences Custom PCR Arrays for DLG3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DLG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLG3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG3 |
Orthologs
for DLG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DLG3 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DLG31 |
discs, large homolog 3 (Drosophila) |
82.73(n)
93.09(a) |
|
428706 XM_426264.3 XP_426264.3 |
lizard
(Anolis carolinensis) |
Reptilia |
DLG36 |
-- |
91(a) |
1 ↔ 1 |
GL343758.1(1990-49090) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.153712 |
Transcribed sequence with moderate similarity to protein more |
80.52(n) |
|
BX694896.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
dlg31 |
discs, large homolog 3 (Drosophila) |
78.01(n)
87.33(a) |
|
564081 XM_003199922.1 XP_003199970.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dlg13 |
establishment and/or maintenance of polarity
of more |
57(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
dlg-13 |
guanylate kinase |
45(a) |
|
X(5514745-5519401) -- |
ENSEMBL Gene Tree for DLG3 (if available)
TreeFam Gene Tree for DLG3 (if available) |
Paralogs
for DLG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DLG3 gene
- MPP62 MPP72 MPP52 DLG22 MPP22 MPP42 DLG42 DLG12
- CASK2 MPP12 MPP32
14 SIMAP similar genes for DLG3 using alignment to 2 protein entries: DLG3_HUMAN (see all proteins):DKFZp761P0818 DLG4 DLG1 SYNJ2BP DLG2 LIN7A
LIN7B TJP2 TAX1BP3 LIN7C GUK1 DKFZp666D023
DKFZp666F1010 PDZD11
DLG3 for paralogs About GeneDecksing
|
Genomic Variants
for DLG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DLG3 (69664705 - 69725340 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DLG3
1 CNV: 7797
Human Gene Mutation Database (HGMD): DLG3
Locus Specific Mutation Databases (LSDB): DLG3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLG3 |
|
Disorders
/ Diseases
for DLG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DLG3 for disorders About GeneDecksing
OMIM gene information: 300189
OMIM disorders: --
UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796
Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300850]. Mental retardationis characterized by significantly sub-average general intellectual functioning associated with impairments inadaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do notmanifest other clinical signs
16  diseases for DLG3: About MalaCardsborjeson-forssman-lehmann syndrome mental retardation, x-linked polyposis fragile x syndrome
autism spectrum disorder partington syndrome fryns syndrome short stature
fg syndrome intellectual disability bipolar disorder hypogonadism
huntington's disease microcephaly schizophrenia neuronitis
3 diseases from the University of Copenhagen DISEASES database for DLG3:Intellectual disability Partington syndrome Fragile X syndrome 3 Novoseek disease relationships for DLG3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: DLG3 (5 documents)
Export disorders for DLG3 gene to outside databases
|
Publications
for DLG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DLG3 gene, integrated from 9 sources (see all 86):
(articles sorted by number of sources associating them with DLG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation. (PubMed id 15185169)1, 2, 9 Tarpey P.... Raymond F.L. (2004)
- Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. (PubMed id 19118189)1, 2 Lee H.W....Kim E. (2008)
- The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. (PubMed id 10725395)1, 2 Garcia R.A.... Buonanno A. (2000)
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
- DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1. (PubMed id 9598320)1, 3 Stathakis D.G....Bryant P.J. (1998)
- Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein. (PubMed id 9188857)1, 2 Makino K.... Saya H. (1997)
- Binding of neuroligins to PSD-95. (PubMed id 9278515)1, 2 Irie M.... Suedhof T.C. (1997)
- Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102. (PubMed id 12576483)1, 9 Seabold G.K....Hell J.W. (2003)
- A novel mutation in the DLG3 gene encoding the synaps e-associated protein 102 (SAP102) causes non-syndromic mental retardation. (PubMed id 19795139)1, 9 Zanni G....Chelly J. (2010)
- DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray. (PubMed id 19167192)1, 9 Qu M....Smits A. (2009)
|
External Searches for DLG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DLG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DLG3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DLG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DLG3 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for DLG3 | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DLG3 |
|
| | |
About This Section
| Patent Information for DLG3 gene:
Search GeneIP for patents involving DLG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DLG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for DLG3 | | OriGene shRNA RFP for DLG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLG3 | | | OriGene Protein Over-expression Lysate for DLG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DLG3 | | OriGene 3'-UTR Clone for DLG3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DLG3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DLG3 | | OriGene Custom Protein Services for DLG3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DLG3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLG3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLG3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLG3 |
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| | Antibodies & Assays for DLG3 |
| | | | Search Tocris compounds for DLG3 |
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 | | | DLG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG3 |
|  |  |  | | | | Search ThermoFisher Antibodies for DLG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG3 |
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