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Aliases for DLG3 Gene

Aliases for DLG3 Gene

  • Discs, Large Homolog 3 (Drosophila) 2 3
  • SAP102 3 4 6
  • Synapse-Associated Protein 102 3 4
  • Neuroendocrine-DLG 3 4
  • MRX90 3 6
  • NEDLG 3 6
  • XLMR 3 4
  • Discs, Large Homolog 3 (Neuroendocrine-Dlg, Drosophila) 2
  • Protein Phosphatase 1, Regulatory Subunit 82 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 82 2
  • Disks Large Homolog 3 3
  • Neuroendocrine-Dlg 2
  • KIAA1232 4
  • PPP1R82 3
  • SAP-102 4
  • MRX 3

External Ids for DLG3 Gene

Previous GeneCards Identifiers for DLG3 Gene

  • GC0XP065842
  • GC0XP067142
  • GC0XP067897
  • GC0XP068531
  • GC0XP069447
  • GC0XP069581
  • GC0XP069664
  • GC0XP063486

Summaries for DLG3 Gene

Entrez Gene Summary for DLG3 Gene

  • This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

GeneCards Summary for DLG3 Gene

DLG3 (Discs, Large Homolog 3 (Drosophila)) is a Protein Coding gene. Diseases associated with DLG3 include partington syndrome and non-syndromic x-linked intellectual disability. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include protein C-terminus binding and PDZ domain binding. An important paralog of this gene is MPP6.

UniProtKB/Swiss-Prot for DLG3 Gene

  • Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling

Gene Wiki entry for DLG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLG3 Gene

Genomics for DLG3 Gene

Regulatory Elements for DLG3 Gene

Genomic Location for DLG3 Gene

70,444,855 bp from pter
70,505,493 bp from pter
60,639 bases
Plus strand

Genomic View for DLG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLG3 Gene

Proteins for DLG3 Gene

  • Protein details for DLG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disks large homolog 3
    Protein Accession:
    Secondary Accessions:
    • B4E0H1
    • D3DVU5
    • Q5JUW6
    • Q5JUW7
    • Q9ULI8

    Protein attributes for DLG3 Gene

    817 amino acids
    Molecular mass:
    90314 Da
    Quaternary structure:
    • Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts with FLTP/C1orf192 (By similarity). Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4.
    • Sequence=BAA86546.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DLG3 Gene

    Alternative splice isoforms for DLG3 Gene


neXtProt entry for DLG3 Gene

Proteomics data for DLG3 Gene at MOPED

Post-translational modifications for DLG3 Gene

  • Ubiquitination at Lys6
  • Modification sites at PhosphoSitePlus

Other Protein References for DLG3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DLG3 (DLG3)

No data available for DME Specific Peptides for DLG3 Gene

Domains for DLG3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q92796
  • Contains 1 guanylate kinase-like domain.
  • Contains 3 PDZ (DHR) domains.
  • Contains 1 SH3 domain.
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with DLG3: view

No data available for Gene Families for DLG3 Gene

Function for DLG3 Gene

Molecular function for DLG3 Gene

GENATLAS Biochemistry:
Drosophila tumor suppressor gene,discs large (Dlg) homolog 3,100kDa,expressed in neuronal and endocrine tissues,putative negative regulator of cell proliferation,through its interaction with APC,critical for synaptogenesis
UniProtKB/Swiss-Prot Function:
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling

Gene Ontology (GO) - Molecular Function for DLG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity IBA --
GO:0005515 protein binding IPI 19118189
GO:0008022 protein C-terminus binding IEA --
GO:0019900 kinase binding IDA 21119615
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with DLG3: view
genes like me logo Genes that share phenotypes with DLG3: view

Animal Models for DLG3 Gene

MGI Knock Outs for DLG3:

Animal Model Products

miRNA for DLG3 Gene

miRTarBase miRNAs that target DLG3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DLG3 Gene

Localization for DLG3 Gene

Subcellular locations from

Jensen Localization Image for DLG3 Gene COMPARTMENTS Subcellular localization image for DLG3 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DLG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction --
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with DLG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DLG3 Gene

Pathways for DLG3 Gene

genes like me logo Genes that share pathways with DLG3: view

Pathways by source for DLG3 Gene

Gene Ontology (GO) - Biological Process for DLG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001736 establishment of planar polarity IEA --
GO:0007268 synaptic transmission TAS --
GO:0007399 nervous system development IBA --
GO:0007411 axon guidance TAS --
GO:0008285 negative regulation of cell proliferation NAS 9188857
genes like me logo Genes that share ontologies with DLG3: view

Compounds for DLG3 Gene

(5) Novoseek inferred chemical compound relationships for DLG3 Gene

Compound -log(P) Hits PubMed IDs
guanylate 71 4
nmda 70.1 13
glutamate 56.7 4
kainate 28.3 1
tyrosine 3.63 1
genes like me logo Genes that share compounds with DLG3: view

Transcripts for DLG3 Gene

Unigene Clusters for DLG3 Gene

Discs, large homolog 3 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLG3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: -

ExUns: 24 ^ 25a · 25b

Relevant External Links for DLG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLG3 Gene

mRNA expression in normal human tissues for DLG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DLG3 Gene

This gene is overexpressed in Brain (25.9), Frontal cortex (7.0), and Placenta (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLG3 Gene

SOURCE GeneReport for Unigene cluster for DLG3 Gene Hs.721586

genes like me logo Genes that share expressions with DLG3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for DLG3 Gene

Orthologs for DLG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DLG3 35
  • 94.53 (n)
  • 99.51 (a)
DLG3 36
  • 100 (a)
(Canis familiaris)
Mammalia DLG3 35
  • 93.88 (n)
  • 98.28 (a)
DLG3 36
  • 87 (a)
(Mus musculus)
Mammalia Dlg3 35
  • 93.06 (n)
  • 99.27 (a)
Dlg3 16
Dlg3 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Dlg3 35
  • 92.7 (n)
  • 99.39 (a)
(Monodelphis domestica)
Mammalia DLG3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
(Pan troglodytes)
Mammalia DLG3 36
  • 95 (a)
(Gallus gallus)
Aves DLG3 35
  • 81.68 (n)
  • 93.7 (a)
DLG3 36
  • 90 (a)
(Anolis carolinensis)
Reptilia DLG3 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15371 35
(Danio rerio)
Actinopterygii LOC100334525 35
  • 78.82 (n)
  • 89.87 (a)
dlg3 36
  • 84 (a)
dlg3 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta dlg1 37
  • 57 (a)
dlg1 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea dlg-1 37
  • 45 (a)
dlg-1 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5033 36
  • 51 (a)
Species with no ortholog for DLG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLG3 Gene

Gene Tree for DLG3 (if available)
Gene Tree for DLG3 (if available)

Paralogs for DLG3 Gene

Paralogs for DLG3 Gene

Selected SIMAP similar genes for DLG3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DLG3: view

Variants for DLG3 Gene

Sequence variations from dbSNP and Humsavar for DLG3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1044422 -- 70,504,244(+) CAACC(A/G)TGCTC utr-variant-3-prime
rs1325084 -- 70,502,289(-) CAAGA(A/G)AATGG utr-variant-3-prime
rs1325085 -- 70,502,064(-) CCCCT(C/T)CACCC intron-variant
rs1886890 -- 70,498,464(+) GAGTA(C/T)TGTAC intron-variant
rs1886891 -- 70,494,634(+) AGGTG(A/G)TGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLG3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
esv33082 CNV Loss 17666407

Relevant External Links for DLG3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLG3 Gene

Disorders for DLG3 Gene

(1) OMIM Diseases for DLG3 Gene (300189)


  • Mental retardation, X-linked 90 (MRX90) [MIM:300850]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:15185169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for DLG3 Gene

(3) Novoseek inferred disease relationships for DLG3 Gene

Disease -log(P) Hits PubMed IDs
mental retardation 64.2 12
schizophrenia 40 7
bipolar disorder 34.7 6

Relevant External Links for DLG3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DLG3: view

No data available for Genatlas for DLG3 Gene

Publications for DLG3 Gene

  1. Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation. (PMID: 15185169) Tarpey P. … Raymond F.L. (Am. J. Hum. Genet. 2004) 3 4 23
  2. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. (PMID: 9581761) Kim J.H. … Huganir R.L. (Neuron 1998) 3 23
  3. Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. (PMID: 12070168) Cai C. … KeinAonen K. (J. Biol. Chem. 2002) 3 23
  4. Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. (PMID: 12175853) Huang Y.Z. … Mei L. (Int. J. Dev. Neurosci. 2002) 3 23
  5. Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102. (PMID: 12576483) Seabold G.K. … Hell J.W. (J. Biol. Chem. 2003) 3 23

Products for DLG3 Gene

  • Addgene plasmids for DLG3

Sources for DLG3 Gene

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