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DLG3 Gene

protein-coding GIFtS: 66

GC0XP069581

discs, large homolog 3 (Drosophila)
(Previous names: discs, large homolog 3 (neuroendocrine-dlg, Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
KIAA1232 ^¹, ², ³
MRX ^²
MRX90 ^¹, ², ⁵
NE-Dlg ^¹, ²
NEDLG ^¹, ², ⁵
Neuroendocrine-DLG ^³
OTTHUMP00000023475 ^²
OTTHUMP00000023476 ^²
SAP-102 ^¹, ²
SAP102 ^¹, ², ³, ⁵
XLMR ^³
neuroendocrine-dlg ^²

Descriptions
Synapse-associated protein 102 ^², ³
bA291O7.3 (discs, large Drosophila homolog 3 (neuroendocrine-dlg) ) ^²
discs large homolog 3 ^²
discs, large homolog 3 (Drosophila) ^²
discs, large homolog 3 (neuroendocrine-dlg, Drosophila) ^¹, ²

External Ids
HGNC: 2902¹
Entrez Gene: 1741²
UniProtKB: Q92796³
Ensembl: ENSG00000082458⁷

Search outside databases for aliases for DLG3 gene

Previous GC identifers: GC0XP065842 GC0XP067142 GC0XP067897 GC0XP068531 GC0XP069447

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796

Function: Required for learning most likely through its role in synaptic plasticity following NMDA

receptor signaling

Gene Wiki entry for DLG3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DLG3 gene

Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1

DLG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP069581: (about GC identifiers)

Start:	69,581,449 bp from pter
End:	69,642,062 bp from pter
Size:	60,614 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796 (See protein sequence)

Recommended Name: Disks large homolog 3

Size: 817 amino acids; 90314 Da

Subunit: Interacts through its PDZ domains with GRIN2B and SYNGAP1. Interacts through its guanylate

kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts through its

PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through

its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3

PDB structures from and Proteopedia :

1UM7 (3D)

2FE5 (3D)

2I1N (3D)

Secondary accessions: Q5JUW7 Q9ULI8

Alternative splicing: 2 isoforms: Q92796-1 Q92796-2 (Named isoforms)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_065781.1 NP_066943.2

ENSEMBL proteins:

ENSP00000363475 ENSP00000363480 ENSP00000194900

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SAP102)
	Human Recombinant Proteins from Abnova (DLG3)

OriGene Purified Recombinant Human Protein: DLG3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IDA	18029348
GO:0005730	nucleolus	IDA	18029348

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Antibodies for DLG3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of DLG3
	Sigma-Aldrich Antibodies for DLG3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DLG3 (SAP102)
	Antibodies from Abcam (SAP102), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DLG3)
	Novus Biologicals Antibodies for DLG3

Assays for DLG3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q92796

ProtoNet protein and cluster: Q92796

3 Blocks protein families:

IPB001452 SH3 domain signature

IPB001478 PDZ/DHR/GLGF domain

IPB008144 Guanylate kinase

UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 3 PDZ (DHR) domains

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DLG3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DLG3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020730

Applied Biosystems Silencer® siRNAs for DLG3

Sigma-Aldrich siRNA and siRNA Panels for DLG3

Sigma-Aldrich shRNA for DLG3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DLG3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_020730
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_020730
untagged cDNA clones in CMV expression vector (see all 2): NM_020730

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021120

UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796

Function: Required for learning most likely through its role in synaptic plasticity following NMDA

receptor signaling

Genatlas biochemistry entry for DLG3:

Drosophila tumor suppressor gene,discs large (Dlg) homolog 3,100kDa,expressed in neuronal and

endocrine tissues,putative negative regulator of cell proliferation,through its interaction with

APC,critical for synaptogenesis

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dlg3):

behavior/neurological

lethality-prenatal/perinatal

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004385	guanylate kinase activity	NAS	--
GO:0005515	protein binding	IPI	16192269 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for DLG3 (Your Favorite Gene powered by Ingenuity)

Purine Metabolism

GeneDecks DLG3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for DLG3

5/52 Interacting proteins for DLG3 (ENSP00000194900³ Q92796^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCA1	O95477¹	STRING (score=.846) EBI-80440, EBI-784112
GDA	Q9Y2T3²	STRING (score=.873) MINT-72657 MINT-72689 MINT-72705 MINT-72686 MINT-72690 MINT-72685
ANXA1	P04083¹	EBI-80440, EBI-354007
CAMK2A	Q9UQM7¹	EBI-80440, EBI-1383687
CUL2	Q13617¹	EBI-80440, EBI-456179

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008285	negative regulation of cell proliferation	NAS	9188857

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DLG3
2 Novoseek chemical compound relationships for DLG3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	61.29	3	12576483 (1), 15219743 (1), 15185169 (1)
tyrosine	5.65	1	12576483 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DLG3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DLG3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020730

Sigma-Aldrich siRNA and siRNA Panels for DLG3

Sigma-Aldrich shRNA for DLG3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020730 NM_021120

REFSEQ mRNAs for DLG3 gene (2 alternative transcripts):

NM_020730.1 NM_021120.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020730 NM_021120

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_020730
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_020730
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_020730

Additional cDNA sequence:

AB033058.1 AB209328.1 AK303377.1 AK304020.1 AK315041.1 AK316518.1 BC093864.1 BC093866.1

U49089.1

7 DOTS entries:

DT.443957 DT.95274749 DT.100782358 DT.121281100 DT.40216899 DT.91842833 DT.91718296

24/179 AceView cDNA sequences (see all 179 ):

AI628170 BM471650 AI628529 BU784486 BM310300 BQ933278 T09193 AB033058

AW182851 BM698201 BM804357 BU071042 BM976042 BM313692 AI628192 BU186986

BU735993 AA765737 BU782687 BX282195 BM451879 AI272678 BQ187175 BQ008470

highest scoring ESTs for DLG3:

AI628170 U49089 AA099876 AA297785 AA297786 AA307058 AA351762 AA464141 AA477443 AA477567

Unigene Cluster for DLG3:

Discs, large homolog 3 (Drosophila)

Hs.716481 [show with all ESTs]

Unigene Representative Sequence: NM_021120

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DLG3 (see all 7 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:															-						-		-		-		-										-				-
SP2:																					-		-		-		-												-
SP3:																									-		-												-
SP4:																									-		-												-		-
SP5:																																							-

ExUns:	24	^	25a	·	25b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DLG3

3 Ensembl transcripts including schematic representations:

ENST00000374355 ENST00000374360 ENST00000194900

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DLG3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DLG3

¹ / ² / ³

11 probe-sets matching DLG3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47413_at²^{, 3}	U95-B	1	1.00	1.00	0.80	1.00	AI628170	1.00	1.00	1.00	1
41453_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.81	U49089	1.00	0.90	0.95	1
43351_at²^{, 3}	U95-B	1	0.94	1.00	0.96	1.21	H99215	0.80	1.00	0.91	1
207732_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021120	0.60	1.00	0.82	1
212729_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI916274	0.80	1.00	0.91	1
212727_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB033058	0.80	1.00	0.91	1
212728_at²^{, 3}	U133-A	1	1.00	1.00	--	--	T62872	0.40	1.00	0.76	1
207732_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212729_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212727_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212728_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DLG3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.716481
Expression variation in blood from EXPOLDB for DLG3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DLG3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DLG3¹	--	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	93.51(n) 97.67(a)	491942 XM_549062.2 XP_549062.2
cow (Bos taurus)	DLG3¹	--	similar to synapse-associated protein 102	94.53(n) 99.51(a)	509882 XM_586942.3 XP_586942.3
rat (Rattus norvegicus)	Dlg3¹	--	discs, large homolog 3 (Drosophila)	92.7(n) 99.39(a)	58948 NM_031639.1 NP_113827.1
mouse (Mus musculus)	Dlg3^{1, 5}	X⁵	discs, large homolog 3 (Drosophila)^{1, 5}	93.06(n)¹ 99.27(a)¹	53310¹ NM_016747.2¹ NP_058027.1¹ AI528859⁵ AK122474⁵ (see all 15)
chicken (Gallus gallus)	DLG3¹	--	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	76.78(n) 83.48(a)	428706 XM_426264.2 XP_426264.2

About this table Species with no ortholog for DLG3

ENSEMBL Gene Tree for DLG3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DLG3 gene

GUK1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/189 NCBI SNPs in DLG3 are shown (see all 189 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1044422^1,2	A,C,F,H,O	69640819(+)	`CAACCG/ATGCTC`	2	--	ut3¹ ese³		8		EU EA WA	732
	rs3828017^1,2	A,C,F,H	69641456(-)	`AACTGA/CCAGAA`	2	--	ut3¹		6		NA EU EA WA	600
	rs3752323^1,2	C,F,H	69642086(-)	`CTTTCG/AACTTA`	2	--	ng3¹		12		EU EA WA NA	844
	rs3811372^1,2	C,F,H	69581162(-)	`TATATC/AGCCAG`	1	--	ng5¹		4		EU EA WA	416
	rs3811373^1,2	F,H	69581019(-)	`GAAAGG/AACGTT`	1	--	ng5¹		4		EU EA WA	418
--	rs4419981^1,2	H	69638866(+)	`ATTCTC/TTTGTG`	2	--	ut3¹ ese³		4		EU EA WA	412
	rs11797456^1,2	C	69582080(+)	`GCAGCA/GGCCCC`	1	G/S	mis¹ ese³		0	--	--	--	--
	rs1325084^1,2	H	69638864(-)	`CAAGAG/AAATGG`	2	--	ut3¹ ese³		4		EU EA WA	402
--	rs12556687^1,2	C	69579617(+)	`tggttG/Ttgtta`	1	--	ng5¹		0	--	--	--	--
	rs5936902^1,2	H	69640338(+)	`TCCCAG/AAGTCT`	2	--	ut3¹		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for DLG3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300189

UniProtKB/Swiss-Prot: DLG3_HUMAN, Q92796

Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300189].

Mental retardation is characterized by significantly sub-average general intellectual functioning

associated with impairments in adaptative behavior and manifested during the developmental period.

Non-syndromic mental retardation patients do not manifest other clinical signs

3 Novoseek disease relationships for DLG3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mental retardation	63.21	13	17546640 (2), 15185169 (2), 16506138 (1), 16053905 (1) (see all 7)
schizophrenia	42.08	8	18033238 (2), 17113057 (1), 16762023 (1), 12777268 (1) (see all 6)
bipolar disorder	37.18	10	17113057 (3), 18033238 (2), 15054476 (1)

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Human Gene Mutation Database: DLG3
Human Genome Epidemiology Navigator: DLG3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/66 PubMed articles for DLG3 gene (see all 66 ):

Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation. (PubMed id 15185169)^{1, 3, 4} Tarpey P.... Raymond F.L. (2004)
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. (PubMed id 10725395)^{3, 4} Garcia R.A.... Buonanno A. (2000)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{3, 4} Nagase T....Ohara O. (1999)
DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1. (PubMed id 9598320)^{2, 3} Stathakis D.G....Bryant P.J. (1998)
Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein. (PubMed id 9188857)^{3, 4} Makino K.... Saya H. (1997)
Binding of neuroligins to PSD-95. (PubMed id 9278515)^{3, 4} Irie M.... Suedhof T.C. (1997)
Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102. (PubMed id 12576483)^{1, 3} Seabold G.K....Hell J.W. (2003)
DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray. (PubMed id 19167192)^{1, 3} Qu M....Smits A. (2009)
Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. (PubMed id 12070168)^{1, 3} Cai C....Keinanen K. (2002)
Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. (PubMed id 12175853)^{1, 3} Huang Y.Z....Mei L. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1741	HGNC: 2902	AceView: DLG3	Ensembl:ENSG00000082458	euGenes: HUgn1741
ECgene: DLG3	H-InvDB: DLG3

(According to HUGE)
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HUGE: KIAA1232

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DLG3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=DLG3

Licensable Technologies for DLG3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DLG3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DLG3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DLG3		Antibodies for DLG3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DLG3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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Antibodies & Assays for DLG3 (SAP102)

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Antibodies for DLG3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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DLG3 Gene at Home site.
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DLG3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for DLG3

Summaries
for DLG3

Genomic Location
for DLG3

Proteins
for DLG3

Protein Domains/
Families
for DLG3

Gene Function
for DLG3

Pathways & Interactions
for DLG3

Drugs & Compounds
for DLG3

Transcripts
for DLG3

Expression
for DLG3

Orthologs
for DLG3

Paralogs
for DLG3

SNPs/Variants
for DLG3

Disorders & Mutations
for DLG3

Medical News
for DLG3

Publications
for DLG3

Search for DLG3

Genome Databases showing DLG3

Other Databases showing DLG3

Specialized Databases showing DLG3

Licensable Technologies
for DLG3

Services
for DLG3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DLG3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor DLG3

Summariesfor DLG3

Genomic Locationfor DLG3

Proteinsfor DLG3

Protein Domains/Familiesfor DLG3

Gene Functionfor DLG3

Pathways & Interactionsfor DLG3

Drugs & Compoundsfor DLG3

Transcriptsfor DLG3

Expression for DLG3

Orthologsfor DLG3

Paralogsfor DLG3

SNPs/Variantsfor DLG3

Disorders & Mutationsfor DLG3

Medical Newsfor DLG3

Publicationsfor DLG3

Search for DLG3

Genome Databases showing DLG3

Other Databases showing DLG3

Specialized Databases showing DLG3

Licensable Technologiesfor DLG3

Servicesfor DLG3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DLG3

Summaries
for DLG3

Genomic Location
for DLG3

Proteins
for DLG3

Protein Domains/
Families
for DLG3

Gene Function
for DLG3

Pathways & Interactions
for DLG3

Drugs & Compounds
for DLG3

Transcripts
for DLG3

Expression
for DLG3

Orthologs
for DLG3

Paralogs
for DLG3

SNPs/Variants
for DLG3

Disorders & Mutations
for DLG3

Medical News
for DLG3

Publications
for DLG3

Licensable Technologies
for DLG3

Services
for DLG3