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DLG2 Gene

protein-coding   GIFtS: 63
GCID: GC11M083166

Discs, Large Homolog 2 (Drosophila)

(Previous names: discs, large homolog 2, chapsyn-110 (Drosophila))
  See DLG2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Discs, Large Homolog 2 (Drosophila)1 2     PSD932
Channel-Associated Protein Of Synapse-1102 3     Channel-Associated Protein Of Synapses, 110kDa2
Postsynaptic Density Protein PSD-932 3     chapsyn-1102
Discs, Large Homolog 2, Chapsyn-110 (Drosophila)1     Discs, Large Homolog 2, Chapsyn-1102
Protein Phosphatase 11     Disks Large Homolog 22
Regulatory Subunit 581     Protein Phosphatase 1, Regulatory Subunit 582
PPP1R582     Chapsyn-1103
PSD-932     

External Ids:    HGNC: 29011   Entrez Gene: 17402   Ensembl: ENSG000001506727   OMIM: 6035835   UniProtKB: Q157003   

Export aliases for DLG2 gene to outside databases

Previous GC identifers: GC11M085497 GC11M084709 GC11M083392 GC11M082896 GC11M082847 GC11M079462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DLG2 Gene:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a
heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold
for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants
encoding different isoforms have been found for this gene. Additional transcript variants have been described,
but their full-length nature is not known. (provided by RefSeq, Dec 2008)

GeneCards Summary for DLG2 Gene:
DLG2 (discs, large homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with DLG2 include bilateral retinoblastoma. GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is MPP7.

UniProtKB/Swiss-Prot: DLG2_HUMAN, Q15700
Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of
NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor
subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at
cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity)

Gene Wiki entry for DLG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLG2 gene promoter:
         Nkx3-1   TBP   Nkx3-1 v1   Nkx2-5   RORalpha1   Nkx3-1 v2   TFIID   FOXO1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DLG2 promoter sequence
   Search Chromatin IP Primers for DLG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q21

DLG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLG2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M083166:  view genomic region     (about GC identifiers)

Start:
83,166,055 bp from pter      End:
85,338,966 bp from pter
Size:
2,172,912 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DLG2_HUMAN, Q15700 (See protein sequence)
Recommended Name: Disks large homolog 2  
Size: 870 amino acids; 97552 Da
Subunit: Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain (By
similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4
(via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG
Sequence caution: Sequence=BAD92489.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for DLG2:
2BYG (3D)        2HE2 (3D)    
Secondary accessions: B7WNY8 F8W9V6 Q59G57 Q5H9Q4 Q68CQ8 Q6ZTA8
Alternative splicing: 5 isoforms:  Q15700-1   Q15700-2   Q15700-3   Q15700-4   Q15700-5   (No experimental confirmation available. Ref.3 (CAI45970) sequence is in conflict in position: 116:D->E)

Explore the universe of human proteins at neXtProt for DLG2: NX_Q15700

Explore proteomics data for DLG2 at MOPED

Post-translational modifications: 

  • Palmitoylation of isoform 1 is not required for targeting to postsynaptic density (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DLG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001136171.1  NP_001136172.1  NP_001136174.1  NP_001193698.1  NP_001355.2  

    ENSEMBL proteins: 
     ENSP00000381355   ENSP00000393049   ENSP00000365272   ENSP00000402275   ENSP00000385113  
     ENSP00000381353   ENSP00000432894   ENSP00000435849   ENSP00000433848   ENSP00000409133  
     ENSP00000391017   ENSP00000436020   ENSP00000381349   ENSP00000436302   ENSP00000434346  
     ENSP00000403239   ENSP00000381346   ENSP00000381344   ENSP00000434095   ENSP00000435809  
     ENSP00000441994   ENSP00000280241   ENSP00000443248   ENSP00000365274  

    DLG2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DLG2

     
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    antibodies-online peptides for DLG2

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    antibodies-online antibodies for DLG2 (69 products) 

    DLG2 Assay Products:

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    Cloud-Clone Corp. ELISAs for DLG2
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    Search eBioscience for ELISAs for DLG2 
    antibodies-online kits for DLG2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    Selected InterPro protein domains (see all 10):
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR016313 DLG1
     IPR001452 SH3_domain
     IPR019583 PDZ_assoc

    Graphical View of Domain Structure for InterPro Entry Q15700

    ProtoNet protein and cluster: Q15700

    3 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB008144 Guanylate kinase


    UniProtKB/Swiss-Prot: DLG2_HUMAN, Q15700
    Domain: An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 3 PDZ (DHR) domains
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with DLG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLG2_HUMAN, Q15700
    Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of
    NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor
    subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at
    cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity)

         Genatlas biochemistry entry for DLG2:
    Drosophila tumor suppressor gene,discs large (Dlg),expressed in neuronal tissues at postsynaptic
    sites,heterodimerizing with DLG4 and recruited into the same NMDA receptor and Shaker-type potassium channel
    clusters

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity TAS8755482
    GO:0005515protein binding IPI15304517
         
    Find genes that share ontologies with DLG2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for DLG2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased number of cells in m  Decreased telomerase activity 
     Increased HPV18 LCR reporter a 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dlg2):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  immune system 
     integument  nervous system 

    Find genes that share phenotypes with DLG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dlg2tm1Dsb for DLG2

       genOway: Develop your customized and physiologically relevant rodent model for DLG2

    miRNA
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    miRTarBase miRNAs that target DLG2:
    hsa-mir-335-5p (MIRT017170), hsa-mir-148b-3p (MIRT019305)

    Block miRNA regulation of human, mouse, rat DLG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DLG2 (see all 156):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-128 hsa-miR-1260b hsa-miR-4275 hsa-miR-149 hsa-miR-508-5p hsa-miR-525-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DLG2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 5): DLG2 (NM_001142702)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLG2_HUMAN, Q15700: Membrane; Lipid-anchor (By similarity). Cell junction, synapse, postsynaptic cell membrane,
    postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Concentrated in soma and
    postsynaptic density of a subset of neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    cytoskeleton2
    nucleus2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS8755482
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0044224juxtaparanode region of axon IEA--
    GO:0045211postsynaptic membrane IEA--

    Find genes that share ontologies with DLG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DLG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    2Neuroscience
    Neuroscience
    3Hippo signaling pathway
    Hippo signaling pathway


    Find genes that share SuperPaths with DLG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DLG2
        Neuroscience

    1 BioSystems Pathway for DLG2
        Wnt Signaling Pathway NetPath


    1 Kegg Pathway  (Kegg details for DLG2):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DLG2
    Interactions:

        GeneGlobe Interaction Network for DLG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DLG2 (Q157001, 2, 3 ENSP000003652724) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP2B2Q018142, 3, ENSP000003241724MINT-73081 I2D: score=3 STRING: ENSP00000324172
    ATP2B4P236342, 3, ENSP000003503104MINT-73082 I2D: score=4 STRING: ENSP00000350310
    GRIN2AQ128793, ENSP000003325494I2D: score=4 STRING: ENSP00000332549
    GRIN1Q055863, ENSP000003606164I2D: score=3 STRING: ENSP00000360616
    GUCY1A2P334023, ENSP000003448744I2D: score=3 STRING: ENSP00000344874
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission IEA--
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0019233sensory perception of pain IEA--
    GO:0046939nucleotide phosphorylation TAS8755482

    Find genes that share ontologies with DLG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLG2

    3 Novoseek inferred chemical compound relationships for DLG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 69.8 1 9786987 (1)
    nmda 53.2 1 17855605 (1)
    glutamate 38.8 1 15304517 (1)



    Find genes that share compounds with DLG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DLG2 gene (5 alternative transcripts): 
    NM_001142699.1  NM_001142700.1  NM_001142702.1  NM_001206769.1  NM_001364.3  

    Unigene Cluster for DLG2:

    Discs, large homolog 2 (Drosophila)
    Hs.367656  [show with all ESTs]
    Unigene Representative Sequence: NM_001142699
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000398309(uc001pai.2 uc010rsy.1 uc021qof.1 uc001paj.2 uc010rsz.1 uc010rta.1 uc001pak.2)
    ENST00000426717(uc010rsx.1 uc010rsw.1) ENST00000376104 ENST00000418306
    ENST00000404783 ENST00000330014 ENST00000529159 ENST00000524982 ENST00000532653
    ENST00000531015(uc010rtb.1) ENST00000457267 ENST00000420775 ENST00000524601
    ENST00000398304 ENST00000530800 ENST00000529399 ENST00000434967 ENST00000529111(uc001pal.1)

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    Selected qRT-PCR Assays for microRNAs that regulate DLG2 (see all 156):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-128 hsa-miR-1260b hsa-miR-4275 hsa-miR-149 hsa-miR-508-5p hsa-miR-525-3p
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    Additional mRNA sequence: 

    AB209252.1 AK094585.1 AK125151.1 AK125152.1 AK126776.1 AK127150.1 AK294375.1 AK295094.1 
    AK295624.1 AK299778.1 AK299797.1 BC104969.1 BC110844.1 BC143964.1 BX537627.1 BX648386.1 
    CR749820.1 CR933674.1 U32376.1 

    17 DOTS entries:

    DT.316448  DT.107455  DT.101969517  DT.91815395  DT.40253142  DT.430121  DT.91692474  DT.120719626 
    DT.101956105  DT.120719420  DT.91690741  DT.97777798  DT.120719430  DT.91668285  DT.95077917  DT.120689 
    DT.91704631 

    Selected AceView cDNA sequences (see all 103):

    T33258 BX279980 AI934913 T08941 F01556 BM721887 Z42039 BX648386 
    AK125152 AK094585 AA773187 Z43127 BM713625 AA333443 AK126776 AK127150 
    AL707742 R41328 BX478360 BM678399 AI708772 AA484044 AA576099 T80521 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DLG2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                    -                                         -                       -     -           -     -                                             
    SP2:        -     -                                                                       -     -                                                               
    SP3:              -                                                                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24a · 24b ^ 25a · 25b
    SP1:  -                     
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for DLG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DLG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAACAG
    DLG2 Expression
    About this image


    DLG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    DLG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367656
        Custom PCR Arrays for DLG2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DLG2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlg21 , 5 discs, large homolog 2 (Drosophila)1, 5 91.21(n)1
    96.78(a)1
      7 (51.07 cM)5
    238591  NM_011807.31  NP_035937.21 
     910907065 
    chicken
    (Gallus gallus)
    Aves DLG21 discs, large homolog 2 (Drosophila) 84.37(n)
    92.94(a)
      419024  XM_004938907.1  XP_004938964.1 
    lizard
    (Anolis carolinensis)
    Reptilia DLG26
    discs, large homolog 2 (Drosophila)
    83(a)
    1 ↔ 1
    3(201507637-201954890)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dlg21 discs, large homolog 2 80.8(n)
    91.62(a)
      100170164  XM_004912193.1  XP_004912250.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dlg21 discs, large (Drosophila) homolog 2 74.27(n)
    86.41(a)
      497638  NM_001012378.2  NP_001012378.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dlg13 establishment and/or maintenance of
    polarity of more
    61(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea dlg-11 , 3 guanylate kinase3
    dlg-11
    46(a)3
    51.24(n)1
    49.62(a)1
      X(5514745-5519401)3
    1808191  NM_001029260.21  NP_001024431.11 


    ENSEMBL Gene Tree for DLG2 (if available)
    TreeFam Gene Tree for DLG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DLG2 gene
    MPP72  DLG32  MPP62  MPP52  MPP22  MPP42  DLG42  DLG12  
    CASK2  MPP32  MPP12  
    Selected SIMAP similar genes for DLG2 using alignment to 19 protein entries:     DLG2_HUMAN (see all proteins) (see all similar genes):
    DKFZp761P0818    DLG1    DLG4    DLG3    SYNJ2BP    TJP2
    LIN7A    LIN7C    MPP1    LIN7B    GRIP1    STAM
    MPP4    MPP7    TAX1BP3    FYN    SCRIB    MPP2

    Find genes that share paralogs with DLG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DLG2 (see all 44980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359494301,2
    C--79466299(+) TTGTT-/AAAAAA 5 -- ut311Minor allele frequency- A:0.50NA 2
    rs556984161,2
    C--79475663(+) AAAAAG/CTATAT 5 -- int13Minor allele frequency- C:0.28NA WA 240
    rs2012106061,2
    --79475663(+) AAAAA-/CTATAT
            
    GTATA
    5 -- int10--------
    rs1819905581,2
    --79475706(+) ATATAC/TATACA 5 -- int10--------
    rs1837279371,2
    --79475708(+) ATATAC/TACACA 5 -- int10--------
    rs722889551,2
    C--79475741(+) AAAAC-/ATATAT
            
    ATATA
    5 -- int10--------
    rs2010761751,2
    C--79475741(+) AAAAC-/ATATATA 5 -- int10--------
    rs1452401511,2
    C--79479875(+) CATTT-/GGAGGAGG 5 -- cds10--------
    rs1491233721,2
    C--79483613(+) TCTTT-/TTTTC 
            
    TTTTC
    5 -- int10--------
    rs774118371,2
    C--79483617(+) TTTTTC/TTTTTC 5 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for DLG2 (83166055 - 83416055 bp, first 250kb of DLG2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DLG2 (see all 103):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661588CNV Deletion23128226
    esv1959476CNV Deletion18987734
    esv2589653CNV Deletion19546169
    dgv229e199CNV Deletion23128226
    esv2664740CNV Deletion23128226
    esv2421768CNV Deletion20811451
    esv2202413CNV Deletion18987734
    esv1506583CNV Deletion17803354
    esv2544867CNV Deletion19546169
    esv2744846CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DLG2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLG2
    DNA2.0 Custom Variant and Variant Library Synthesis for DLG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603583    OMIM disorders: --

    1 disease for DLG2:    
    About MalaCards
    bilateral retinoblastoma

    2 diseases from the University of Copenhagen DISEASES database for DLG2:
    Bilateral retinoblastoma     Renal oncocytoma

    Find genes that share disorders with DLG2           About GenesLikeMe

    Genetic Association Database (GAD): DLG2
    Human Genome Epidemiology (HuGE) Navigator: DLG2 (6 documents)

    Export disorders for DLG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DLG2 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with DLG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (PubMed id 8755482)1, 2, 3 Kim E.... Sheng M. (Neuron 1996)
    2. An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. (PubMed id 15304517)1, 2, 9 Leyland M.L. and Dart C. (J. Biol. Chem. 2004)
    3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (PLoS Genet. 2012)
    4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family Study. (PubMed id 19931931)1, 4 Palmer N.D....Bowden D.W. (Diabetes Res. Clin. Pract. 2010)
    7. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    9. Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)1, 4 Guilmatre A....Campion D. (Arch. Gen. Psychiatry 2009)
    10. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (PubMed id 19570815)1, 4 Estrada K....Kayser M. (Hum. Mol. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1740 HGNC: 2901 AceView: DLG2andFLJ37266 Ensembl:ENSG00000150672 euGenes: HUgn1740
    ECgene: DLG2 Kegg: 1740 H-InvDB: DLG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DLG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DLG2 gene:
    Search GeneIP for patents involving DLG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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