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DLG2 Gene

protein-coding GIFtS: 62

GC11M082847

discs, large homolog 2 (Drosophila)
(Previous names: discs, large homolog 2, chapsyn-110 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
Chapsyn-110 ^³
DKFZp781D1854 ^²
DKFZp781E0954 ^²
FLJ37266 ^²
MGC131811 ^²
OTTHUMP00000165969 ^²
PSD-93 ^¹, ²
PSD93 ^¹, ²
chapsyn-110 ^¹, ²

Descriptions
Channel-associated protein of synapse-110 ^³
Postsynaptic density protein PSD-93 ^³
channel-associated protein of synapses, 110kDa ^²
discs, large homolog 2 (Drosophila) ^²
discs, large homolog 2, chapsyn-110 ^²
discs, large homolog 2, chapsyn-110 (Drosophila) ^¹

External Ids
HGNC: 2901¹
Entrez Gene: 1740²
UniProtKB: Q15700³
Ensembl: ENSG00000150672⁷

Search outside databases for aliases for DLG2 gene

Previous GC identifers: GC11M085497 GC11M084709 GC11M083392 GC11M082896

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DLG2:

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded

protein forms a heterodimer with a related family member that may interact at postsynaptic sites

to form a multimeric scaffold for the clustering of receptors, ion channels, and associated

signaling proteins. Multiple transcript variants encoding different isoforms have been found for

this gene. Additional transcript variants have been described, but their full-length nature is not

known. [provided by RefSeq]

UniProtKB/Swiss-Prot: DLG2_HUMAN, Q15700

Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates

surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the

cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels.

Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic

protein scaffold of excitatory synapses (By similarity)

Gene Wiki entry for DLG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DLG2 gene

Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q21

DLG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M082847: (about GC identifiers)

Start:	82,843,701 bp from pter
End:	85,015,962 bp from pter
Size:	2,172,262 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DLG2_HUMAN, Q15700 (See protein sequence)

Recommended Name: Disks large homolog 2

Size: 870 amino acids; 97552 Da

Subunit: Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with

C-terminus of KCNJ2/Kir2.1 through one of its PDZ domains

Subcellular location: Membrane; Lipid-anchor (By similarity). Cell junction, synapse, postsynaptic

cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity).

Note=Concentrated in soma and postsynaptic density of a subset of neurons (By similarity)

PDB structure from and Proteopedia :

2BYG (3D)

2HE2 (3D)

Secondary accessions: Q59G57 Q68CQ8 Q6ZTA8

Alternative splicing: 4 isoforms: Q15700-1 Q15700-2 Q15700-3 Q15700-4

Post-translational modifications:

Palmitoylation of isoform 1 is not required for targeting to postsynaptic density (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001136171.1 NP_001136172.1 NP_001136174.1 NP_001355.2

ENSEMBL proteins:

ENSP00000365272 ENSP00000385113 ENSP00000381355 ENSP00000381353 ENSP00000280241 ENSP00000365274

ENSP00000381349 ENSP00000381346 ENSP00000381344

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for DLG2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PSD93)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	8755482
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

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Antibodies for DLG2:

	Invitrogen Antibodies for DLG2
	Millipore Mono- and Polyclonal Antibodies for the study of DLG2
	Sigma-Aldrich Antibodies for DLG2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DLG2 (PSD93)
	Antibodies from Abcam (PSD93), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for DLG2

Assays for DLG2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15700

ProtoNet protein and cluster: Q15700

3 Blocks protein families:

IPB001452 SH3 domain signature

IPB001478 PDZ/DHR/GLGF domain

IPB008144 Guanylate kinase

UniProtKB/Swiss-Prot: DLG2_HUMAN, Q15700

Domain: Isoform 2 has an L27 domain close to N-terminus

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 3 PDZ (DHR) domains

Similarity: Contains 1 SH3 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DLG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DLG2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001364

Applied Biosystems Silencer® siRNAs for DLG2

Sigma-Aldrich siRNA and siRNA Panels for DLG2

Sigma-Aldrich shRNA for DLG2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001142699
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001142699
untagged cDNA clones in CMV expression vector (see all 5): NM_001142699

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001142699

UniProtKB/Swiss-Prot: DLG2_HUMAN, Q15700

Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates

surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the

cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels.

Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic

protein scaffold of excitatory synapses (By similarity)

Genatlas biochemistry entry for DLG2:

Drosophila tumor suppressor gene,discs large (Dlg),expressed in neuronal tissues at postsynaptic

sites,heterodimerizing with DLG4 and recruited into the same NMDA receptor and Shaker-type

potassium channel clusters

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dlg2):

behavior/neurological

nervous system

touch/vibrissae

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004385	guanylate kinase activity	TAS	8755482
GO:0005515	protein binding	IPI	15304517 16192269

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for DLG2 (Your Favorite Gene powered by Ingenuity)

Purine Metabolism

GeneDecks DLG2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DLG2

5/8 Interacting proteins for DLG2 (ENSP00000365272³ Q15700^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCA1	O95477¹	STRING (score=.846) EBI-80426, EBI-784112
Kcnj2 Kcnj2 (xeno)	P35561¹	EBI-663057, EBI-703793
ATP2B2	Q01814²	MINT-73081
ATP2B4	P23634²	MINT-73082
GRIN2B	ENSP00000279593³	STRING (score=.948)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DLG2
1 Novoseek chemical compound relationship for DLG2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	60.59	1	9786987 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DLG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DLG2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001364

Sigma-Aldrich siRNA and siRNA Panels for DLG2

Sigma-Aldrich shRNA for DLG2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142699 NM_001142700 NM_001142702 NM_001364

REFSEQ mRNAs for DLG2 gene (4 alternative transcripts):

NM_001142699.1 NM_001142700.1 NM_001142702.1 NM_001364.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142699 NM_001142700 NM_001142702 NM_001364

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001142699
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001142699
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001142699

Additional cDNA sequence:

AB209252.1 AK094585.1 AK125151.1 AK125152.1 AK126776.1 AK127150.1 AK294375.1 AK295094.1

AK295624.1 AK299778.1 AK299797.1 BC104969.1 BC110844.1 BC143964.1 BX537627.1 BX648386.1

CR749820.1 CR933674.1 U32376.1

12 DOTS entries:

DT.316448 DT.107455 DT.101969517 DT.91815395 DT.40253142 DT.91692474 DT.101956105 DT.120719420

DT.97777798 DT.120719430 DT.91668285 DT.95077917

24/103 AceView cDNA sequences (see all 103 ):

AK094585 AK125152 Z42039 BM721887 BX279980 AI934913 BM713625 AA333443

AK126776 BX648386 T08941 F01556 T33258 AK127150 AL707742 AA773187

Z43127 AA484113 AI886611 R41328 AW953197 BX537627 Z39212 BX478360

highest scoring ESTs for DLG2:

U32376 AL700031 AL700937 AA057445 AB209252 AI015942 AI307288 AI381385 AI669774 AI769796

Unigene Cluster for DLG2:

Discs, large homolog 2 (Drosophila)

Hs.654862 [show with all ESTs]

Unigene Representative Sequence: NM_001142699

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DLG2

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	·	16c	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:							-														-								-		-				-		-
SP2:			-		-																								-		-
SP3:					-
SP4:
SP5:

ExUns:	24a	·	24b	^	25a	·	25b
SP1:	-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DLG2

9 Ensembl transcripts including schematic representations:

ENST00000376104 ENST00000404783 ENST00000398309 ENST00000330014 ENST00000280241 ENST00000376106

ENST00000398304 ENST00000398301 ENST00000398299

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DLG2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DLG2

¹ / ² / ³

7 probe-sets matching DLG2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35945_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.37	U32376	1.00	1.00	1.00	1
91633_at²^{, 3}	U95-E	1	1.00	1.00	0.84	1.39	H05887	0.40	0.67	0.55	1
64485_at²^{, 3}	U95-C	1	1.00	1.00	0.96	1.32	AA057445	0.60	1.00	0.82	1
228973_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA057445	0.60	1.00	0.82	1
206253_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001364	0.60	1.00	0.82	1
228973_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206253_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGGAAACAG

SOURCE GeneReport for Unigene cluster: Hs.654862
Expression variation in blood from EXPOLDB for DLG2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DLG2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DLG2¹	--	discs, large homolog 2, chapsyn-110 (Drosophila)	95.2(n) 98.98(a)	485158 XM_542276.2 XP_542276.2
chimpanzee (Pan troglodytes)	DLG2¹	--	discs, large homolog 2, chapsyn-110 (Drosophila)	99.77(n) 99.77(a)	466728 XM_001175212.1 XP_001175212.1
cow (Bos taurus)	DLG2¹	--	similar to chapsyn-110	94.18(n) 98.96(a)	505383 XM_581662.3 XP_581662.3
rat (Rattus norvegicus)	Dlg2¹	--	discs, large homolog 2 (Drosophila)	91.31(n) 96.71(a)	64053 NM_022282.1 NP_071618.1
mouse (Mus musculus)	Dlg2^{1, 5}	7 (47.60 cM)⁵	discs, large homolog 2 (Drosophila)^{1, 5}	91.28(n)¹ 96.83(a)¹	23859¹ NM_011807.2¹ NP_035937.2¹ AA250296⁵ AF069774⁵ (see all 20)

About this table Species with no ortholog for DLG2

ENSEMBL Gene Tree for DLG2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DLG2 gene

DLG1² DLG4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/8013 NCBI SNPs in DLG2 are shown (see all 8013 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 2791)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2512676^1,2	A,C,F,H,O	82844368(+)	`GTGTGT/GGTTTC`	1	--	ut3¹		5		EA EU WA	1162
	rs2507850^1,2	A,C,F,H,O	82843293(+)	`AGGGTG/ATATAA`	1	--	ng5¹		11		NA EU EA WA	978
	rs2155413^1,2	A,C,F,H	84312438(-)	`ACAATT/GATCCT`	1	--	ng3¹		8		EU EA WA	840
	rs17145219^1,2	C,F,H	82844985(+)	`GCAGGC/GTGGCT`	1	--	ut3¹		11		NA EU EA WA	952
	rs4411300^1,2	C,F,H	82843560(+)	`ACTTCC/ATCTCA`	1	--	ng5¹		8		EU EA WA	838
	rs4533060^1,2	C,F,H	82848003(+)	`ATGTCG/ATCTCC`	1	--	ut3¹ ese³		7		EU EA WA NA	560
	rs11233623^1,2	F,H	82847076(+)	`AGGCAG/TTTCAG`	1	--	ut3¹		4		EU EA WA	418
	rs7944336^1,2	H	82843517(+)	`GATGGT/GAACCA`	1	--	ng5¹		4		EU EA WA	418
--	rs12574806^1,2	C	83222353(+)	`GCTGGC/TCCACC`	1	G/G	syn¹ ese³		0	--	--	--	--
	rs34857356^1,2	F	82860374(+)	`GATCCG/TATCCT`	1	R/R	syn¹		1		NA	50

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HapMap Linkage Disequilibrium images for DLG2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603583

Human Genome Epidemiology Navigator: DLG2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/47 PubMed articles for DLG2 gene (see all 47 ):

Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (PubMed id 8755482)^{2, 3, 4} Kim E.... Sheng M. (1996)
An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. (PubMed id 15304517)^{1, 3, 4} Leyland M.L. and Dart C. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Fine-scale physical map of the 11q21 region surrounding the human DLG2 locus, the gene encoding Chapsyn-110. (PubMed id 9806853)^{2, 3} Stathakis D.G....Bryant P.J. (1998)
Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. (PubMed id 9786987)^{1, 3} Brenman J.E....Bredt D.S. (1998)
Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. (PubMed id 12070168)^{1, 3} Cai C....Keinanen K. (2002)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)³ GratacA^s M....Carracedo A. (2008)
A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)³ Melzer D....Ferrucci L. (2008)
Upregulated expression of postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA in temporal lobe tissue of epilepsy. (PubMed id 17506987)³ Liu F.Y....Li Y.L. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1740	HGNC: 2901	AceView: DLG2andFLJ37266	Ensembl:ENSG00000150672	euGenes: HUgn1740
ECgene: DLG2	H-InvDB: DLG2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for DLG2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DLG2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DLG2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DLG2		Antibodies for DLG2
	Explore super-pooled esiRNAs		Proteins for DLG2
	Lentivirus-delivered shRNAs for DLG2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies & Assays for DLG2 (PSD93)

	Recombinant Proteins (PSD93)
	Antibodies (PSD93)

Search OriGene for DLG2

Search Tocris compounds for DLG2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for DLG2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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DLG2 Gene at Home site.
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DLG2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for DLG2

Summaries
for DLG2

Genomic Location
for DLG2

Proteins
for DLG2

Protein Domains/
Families
for DLG2

Gene Function
for DLG2

Pathways & Interactions
for DLG2

Drugs & Compounds
for DLG2

Transcripts
for DLG2

Expression
for DLG2

Orthologs
for DLG2

Paralogs
for DLG2

SNPs/Variants
for DLG2

Disorders & Mutations
for DLG2

Medical News
for DLG2

Publications
for DLG2

Search for DLG2

Genome Databases showing DLG2

Other Databases showing DLG2

Specialized Databases showing DLG2

Licensable Technologies
for DLG2

Services
for DLG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DLG2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor DLG2

Summariesfor DLG2

Genomic Locationfor DLG2

Proteinsfor DLG2

Protein Domains/Familiesfor DLG2

Gene Functionfor DLG2

Pathways & Interactionsfor DLG2

Drugs & Compoundsfor DLG2

Transcriptsfor DLG2

Expression for DLG2

Orthologsfor DLG2

Paralogsfor DLG2

SNPs/Variantsfor DLG2

Disorders & Mutationsfor DLG2

Medical Newsfor DLG2

Publicationsfor DLG2

Search for DLG2

Genome Databases showing DLG2

Other Databases showing DLG2

Specialized Databases showing DLG2

Licensable Technologiesfor DLG2

Servicesfor DLG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DLG2

Summaries
for DLG2

Genomic Location
for DLG2

Proteins
for DLG2

Protein Domains/
Families
for DLG2

Gene Function
for DLG2

Pathways & Interactions
for DLG2

Drugs & Compounds
for DLG2

Transcripts
for DLG2

Expression
for DLG2

Orthologs
for DLG2

Paralogs
for DLG2

SNPs/Variants
for DLG2

Disorders & Mutations
for DLG2

Medical News
for DLG2

Publications
for DLG2

Licensable Technologies
for DLG2

Services
for DLG2