Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DLG2 Gene

Aliases for DLG2 Gene

  • Discs, Large Homolog 2 (Drosophila) 2 3
  • Channel-Associated Protein Of Synapse-110 3 4
  • Postsynaptic Density Protein PSD-93 3 4
  • Chapsyn-110 3 4
  • Discs, Large Homolog 2, Chapsyn-110 (Drosophila) 2
  • Channel-Associated Protein Of Synapses, 110kDa 3
  • Protein Phosphatase 1, Regulatory Subunit 58 3
  • Discs, Large Homolog 2, Chapsyn-110 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 58 2
  • Disks Large Homolog 2 3
  • Discs Large 2 3
  • PPP1R58 3
  • PSD-93 3
  • PSD93 3

External Ids for DLG2 Gene

Summaries for DLG2 Gene

Entrez Gene Summary for DLG2 Gene

  • This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

GeneCards Summary for DLG2 Gene

DLG2 (Discs, Large Homolog 2 (Drosophila)) is a Protein Coding gene. Diseases associated with DLG2 include bilateral retinoblastoma. Among its related pathways are Hippo signaling pathway and Wnt signaling pathway (KEGG). GO annotations related to this gene include guanylate kinase activity. An important paralog of this gene is MPP6.

UniProtKB/Swiss-Prot for DLG2 Gene

  • Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Gene Wiki entry for DLG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLG2 Gene

Genomics for DLG2 Gene

Genomic Location for DLG2 Gene

Start:
83,455,012 bp from pter
End:
85,627,922 bp from pter
Size:
2,172,911 bases
Orientation:
Minus strand

Genomic View for DLG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLG2 Gene

Regulatory Elements for DLG2 Gene

Proteins for DLG2 Gene

  • Protein details for DLG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15700-DLG2_HUMAN
    Recommended name:
    Disks large homolog 2
    Protein Accession:
    Q15700
    Secondary Accessions:
    • B7WNY8
    • F8W9V6
    • Q59G57
    • Q5H9Q4
    • Q68CQ8
    • Q6ZTA8

    Protein attributes for DLG2 Gene

    Size:
    870 amino acids
    Molecular mass:
    97552 Da
    Quaternary structure:
    • Interacts through its PDZ domains with NETO1 (By similarity). Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains (PubMed:15304517). Interacts with KCNJ4 (By similarity), Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts with FASLG (PubMed:19807924). Interacts with KCNJ4 (By similarity). Interacts with ADAM22 (By similarity).
    SequenceCaution:
    • Sequence=BAD92489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DLG2 Gene

    Alternative splice isoforms for DLG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLG2 Gene

Proteomics data for DLG2 Gene at MOPED

Post-translational modifications for DLG2 Gene

  • Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DLG2 Gene

Domains for DLG2 Gene

Gene Families for DLG2 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

UniProtKB/Swiss-Prot:

DLG2_HUMAN
Domain:
  • An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27:
    • Q15700
  • Contains 1 guanylate kinase-like domain.:
    • Q15700
  • Contains 3 PDZ (DHR) domains.:
    • Q15700
  • Contains 1 SH3 domain.:
    • Q15700
Family:
  • Belongs to the MAGUK family.:
    • Q15700
genes like me logo Genes that share domains with DLG2: view

Function for DLG2 Gene

Molecular function for DLG2 Gene

GENATLAS Biochemistry: Drosophila tumor suppressor gene,discs large (Dlg),expressed in neuronal tissues at postsynaptic sites,heterodimerizing with DLG4 and recruited into the same NMDA receptor and Shaker-type potassium channel clusters
UniProtKB/Swiss-Prot Function: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Gene Ontology (GO) - Molecular Function for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity TAS 8755482
GO:0005515 protein binding IPI 15304517
GO:0019900 kinase binding IDA 21119615
GO:0035255 ionotropic glutamate receptor binding IBA --
genes like me logo Genes that share ontologies with DLG2: view
genes like me logo Genes that share phenotypes with DLG2: view

Animal Models for DLG2 Gene

MGI Knock Outs for DLG2:

miRNA for DLG2 Gene

miRTarBase miRNAs that target DLG2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DLG2 Gene

Localization for DLG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLG2 Gene

Cell membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250 UniProtKB:Q63622}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLG2 Gene COMPARTMENTS Subcellular localization image for DLG2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 8755482
GO:0008076 colocalizes_with voltage-gated potassium channel complex ISS --
GO:0008328 colocalizes_with ionotropic glutamate receptor complex IBA --
GO:0014069 postsynaptic density IBA --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with DLG2: view

Pathways for DLG2 Gene

genes like me logo Genes that share pathways with DLG2: view

Pathways by source for DLG2 Gene

1 Cell Signaling Technology pathway for DLG2 Gene
1 BioSystems pathway for DLG2 Gene
1 KEGG pathway for DLG2 Gene

Gene Ontology (GO) - Biological Process for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IBA --
GO:0007399 nervous system development IBA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0019233 sensory perception of pain IEA --
GO:0043113 receptor clustering IBA --
genes like me logo Genes that share ontologies with DLG2: view

Compounds for DLG2 Gene

(3) Novoseek inferred chemical compound relationships for DLG2 Gene

Compound -log(P) Hits PubMed IDs
guanylate 69.8 1
nmda 53.2 1
glutamate 38.8 1
genes like me logo Genes that share compounds with DLG2: view

Transcripts for DLG2 Gene

Unigene Clusters for DLG2 Gene

Discs, large homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5:

ExUns: 24a · 24b ^ 25a · 25b
SP1: -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for DLG2 Gene

GeneLoc Exon Structure for
DLG2
ECgene alternative splicing isoforms for
DLG2

Expression for DLG2 Gene

mRNA expression in normal human tissues for DLG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLG2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Hippocampus (4.9), Brain - Frontal Cortex (BA9) (4.8), Brain - Cortex (4.5), and Brain - Amygdala (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLG2 Gene

SOURCE GeneReport for Unigene cluster for DLG2 Gene Hs.367656

genes like me logo Genes that share expressions with DLG2: view

Orthologs for DLG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLG2 36
  • 99.76 (n)
  • 99.69 (a)
DLG2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLG2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLG2 36
  • 94.34 (n)
  • 97.39 (a)
DLG2 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlg2 36
  • 91.21 (n)
  • 96.78 (a)
Dlg2 16
Dlg2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DLG2 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlg2 36
  • 91.21 (n)
  • 96.66 (a)
chicken
(Gallus gallus)
Aves DLG2 36
  • 84.37 (n)
  • 92.94 (a)
DLG2 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLG2 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlg2 36
  • 80.8 (n)
  • 91.62 (a)
zebrafish
(Danio rerio)
Actinopterygii dlg2 36
  • 74.27 (n)
  • 86.41 (a)
dlg2 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dlg1 37
  • 32 (a)
OneToMany
dlg1 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea dlg-1 36
  • 51.24 (n)
  • 49.62 (a)
dlg-1 37
  • 38 (a)
OneToMany
dlg-1 38
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5033 37
  • 57 (a)
OneToMany
Species with no ortholog for DLG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLG2 Gene

ENSEMBL:
Gene Tree for DLG2 (if available)
TreeFam:
Gene Tree for DLG2 (if available)

Paralogs for DLG2 Gene

Paralogs for DLG2 Gene

genes like me logo Genes that share paralogs with DLG2: view

Variants for DLG2 Gene

Sequence variations from dbSNP and Humsavar for DLG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs62388 -- 85,509,117(+) ACACA(A/G)AAAAT intron-variant
rs149475 -- 85,424,309(-) cccac(A/C)gatcc intron-variant
rs158088 -- 85,424,193(-) ccccc(A/C)gctag intron-variant
rs158089 -- 85,426,887(+) aaaat(G/T)agacg intron-variant
rs158217 -- 85,518,412(-) atgct(G/T)ccaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLG2 Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV Loss 17666407
esv8265 CNV Gain 19470904
esv270109 CNV Insertion 20981092
esv2589653 CNV Deletion 19546169
dgv228e199 CNV Deletion 23128226
esv1959476 CNV Deletion 18987734
esv22170 CNV Loss 19812545
esv2544219 CNV Loss 19546169
esv26008 CNV Loss 19812545
dgv1240n71 CNV Gain 21882294
dgv1241n71 CNV Gain 21882294
nsv898024 CNV Gain 21882294
nsv516859 CNV Loss 19592680
nsv468765 CNV Loss 19166990
esv2618406 CNV Deletion 19546169
nsv527778 CNV Loss 19592680
esv273492 CNV Insertion 20981092
esv269776 CNV Insertion 20981092
dgv1242n71 CNV Loss 21882294
esv267715 CNV Insertion 20981092
dgv1243n71 CNV Loss 21882294
nsv898029 CNV Loss 21882294
nsv898030 CNV Loss 21882294
esv2751034 CNV Gain 17911159
esv2744839 CNV Deletion 23290073
esv2661588 CNV Deletion 23128226
esv1421802 CNV Insertion 17803354
nsv513745 CNV Insertion 21212237
nsv516717 CNV Gain 19592680
esv2657838 CNV Deletion 23128226
esv2456833 CNV Deletion 19546169
esv270247 CNV Insertion 20981092
esv272606 CNV Insertion 20981092
esv1005592 CNV Insertion 20482838
nsv415 CNV Loss 18451855
esv8123 CNV Gain 19470904
nsv898031 CNV Loss 21882294
esv2664740 CNV Deletion 23128226
nsv524869 CNV Loss 19592680
nsv507605 CNV Insertion 20534489
esv6392 CNV Gain 19470904
nsv508642 CNV Loss 20534489
nsv519456 CNV Loss 19592680
nsv520103 CNV Loss 19592680
esv2744840 CNV Deletion 23290073
esv2740842 CNV Deletion 23290073
nsv468766 CNV Loss 19166990
nsv898032 CNV Loss 21882294
nsv898033 CNV Loss 21882294
nsv898034 CNV Loss 21882294
dgv1244n71 CNV Loss 21882294
nsv898036 CNV Loss 21882294
nsv519411 CNV Loss 19592680
nsv527928 CNV Gain 19592680
nsv898038 CNV Loss 21882294
nsv898039 CNV Loss 21882294
nsv898040 CNV Loss 21882294
nsv468767 CNV Loss 19166990
nsv8849 CNV Loss 18304495
esv2673432 CNV Deletion 23128226
nsv516146 CNV Loss 19592680
esv2744842 CNV Deletion 23290073
esv2744843 CNV Deletion 23290073
esv2744844 CNV Deletion 23290073
esv1506583 CNV Deletion 17803354
dgv408e1 CNV Complex 17122850
nsv510264 CNV Loss 20534489
nsv898041 CNV Loss 21882294
nsv482998 CNV Loss 15286789
esv273727 CNV Insertion 20981092
esv269387 CNV Insertion 20981092
esv2544867 CNV Deletion 19546169
esv2281631 CNV Deletion 18987734
esv2744845 CNV Deletion 23290073
esv987708 CNV Deletion 20482838
esv2673933 CNV Deletion 23128226
dgv75n21 CNV Loss 19592680
esv2744846 CNV Deletion 23290073
esv269724 CNV Insertion 20981092
esv2744847 CNV Deletion 23290073
nsv898042 CNV Loss 21882294
dgv1245n71 CNV Loss 21882294
esv2665612 CNV Deletion 23128226
esv2657415 CNV Deletion 23128226
nsv898045 CNV Loss 21882294
esv2622674 CNV Deletion 19546169
nsv898046 CNV Loss 21882294
dgv1246n71 CNV Loss 21882294
essv7704 CNV CNV 17122850
esv678 CNV CNV 17122850
nsv8850 CNV Loss 18304495
nsv898049 CNV Loss 21882294
nsv518780 CNV Loss 19592680
esv2471612 CNV Deletion 19546169
esv2202413 CNV Deletion 18987734
esv2657074 CNV Deletion 23128226
nsv416 CNV Insertion 18451855
dgv229e199 CNV Deletion 23128226
esv2421768 CNV Deletion 20811451
esv32962 CNV Loss 17666407
nsv515581 CNV Loss 19592680
esv2675105 CNV Deletion 23128226
esv2617997 CNV Deletion 19546169

Relevant External Links for DLG2 Gene

HapMap Linkage Disequilibrium report
DLG2
Human Gene Mutation Database (HGMD)
DLG2

Disorders for DLG2 Gene

(1) MalaCards Diseases for DLG2 Gene

Search for DLG2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DLG2 Gene

Relevant External Links for DLG2

Genetic Association Database (GAD)
DLG2
Human Genome Epidemiology (HuGE) Navigator
DLG2
genes like me logo Genes that share disorders with DLG2: view

No data available for UniProtKB/Swiss-Prot for DLG2 Gene

Publications for DLG2 Gene

  1. An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. (PMID: 15304517) Leyland M.L. … Dart C. (J. Biol. Chem. 2004) 3 4 23
  2. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (PMID: 8755482) Kim E. … Sheng M. (Neuron 1996) 2 3 4
  3. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. (PMID: 9786987) Brenman J.E. … Bredt D.S. (J. Neurosci. 1998) 3 23
  4. Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. (PMID: 12070168) Cai C. … KeinAonen K. (J. Biol. Chem. 2002) 3 23
  5. Fine-scale physical map of the 11q21 region surrounding the human DLG2 locus, the gene encoding Chapsyn-110. (PMID: 9806853) Stathakis D.G. … Bryant P.J. (Genomics 1998) 2 3

Products for DLG2 Gene

Sources for DLG2 Gene

Back to Top

Content