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Aliases for DLG2 Gene

Aliases for DLG2 Gene

  • Discs Large Homolog 2 2 3
  • Channel-Associated Protein Of Synapse-110 3 4
  • Discs, Large Homolog 2 (Drosophila) 2 5
  • Postsynaptic Density Protein PSD-93 3 4
  • Chapsyn-110 3 4
  • Discs, Large Homolog 2, Chapsyn-110 (Drosophila) 2
  • Channel-Associated Protein Of Synapses, 110kDa 3
  • Protein Phosphatase 1, Regulatory Subunit 58 3
  • Discs, Large Homolog 2, Chapsyn-110 3
  • Discs, Large Homolog 2 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 58 2
  • Discs Large 2 3
  • PPP1R58 3
  • PSD-93 3
  • PSD93 3

External Ids for DLG2 Gene

Previous GeneCards Identifiers for DLG2 Gene

  • GC11M085497
  • GC11M084709
  • GC11M082896
  • GC11M082847
  • GC11M083166
  • GC11M079462

Summaries for DLG2 Gene

Entrez Gene Summary for DLG2 Gene

  • This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]

GeneCards Summary for DLG2 Gene

DLG2 (Discs Large Homolog 2) is a Protein Coding gene. Diseases associated with DLG2 include Renal Oncocytoma and Bilateral Retinoblastoma. Among its related pathways are Wnt signaling pathway (KEGG) and Hippo signaling pathway. GO annotations related to this gene include kinase binding and guanylate kinase activity. An important paralog of this gene is MPP6.

UniProtKB/Swiss-Prot for DLG2 Gene

  • Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Gene Wiki entry for DLG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLG2 Gene

Genomics for DLG2 Gene

Regulatory Elements for DLG2 Gene

Enhancers for DLG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DLG2 on UCSC Golden Path with GeneCards custom track

Promoters for DLG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLG2 Gene

Chromosome:
11
Start:
83,455,012 bp from pter
End:
85,628,534 bp from pter
Size:
2,173,523 bases
Orientation:
Minus strand

Genomic View for DLG2 Gene

Genes around DLG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLG2 Gene

Proteins for DLG2 Gene

  • Protein details for DLG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15700-DLG2_HUMAN
    Recommended name:
    Disks large homolog 2
    Protein Accession:
    Q15700
    Secondary Accessions:
    • B7WNY8
    • F8W9V6
    • Q59G57
    • Q5H9Q4
    • Q68CQ8
    • Q6ZTA8

    Protein attributes for DLG2 Gene

    Size:
    870 amino acids
    Molecular mass:
    97552 Da
    Quaternary structure:
    • Interacts through its PDZ domains with NETO1 (By similarity). Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains (PubMed:15304517). Interacts with KCNJ4 (By similarity), Interacts with FRMPD4 (via C-terminus) (PubMed:19118189). Interacts with LRFN1, LRFN2 and LRFN4 (PubMed:16630835). Interacts with FASLG (PubMed:19807924). Interacts with KCNJ4 (By similarity). Interacts with ADAM22 (By similarity).
    SequenceCaution:
    • Sequence=BAD92489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DLG2 Gene

    Alternative splice isoforms for DLG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLG2 Gene

Proteomics data for DLG2 Gene at MOPED

Post-translational modifications for DLG2 Gene

  • Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DLG2 (PSD-93)

No data available for DME Specific Peptides for DLG2 Gene

Domains & Families for DLG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q15700

UniProtKB/Swiss-Prot:

DLG2_HUMAN :
  • An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
  • Belongs to the MAGUK family.
Domain:
  • An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27.
  • Contains 1 guanylate kinase-like domain.
  • Contains 3 PDZ (DHR) domains.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with DLG2: view

Function for DLG2 Gene

Molecular function for DLG2 Gene

GENATLAS Biochemistry:
Drosophila tumor suppressor gene,discs large (Dlg),expressed in neuronal tissues at postsynaptic sites,heterodimerizing with DLG4 and recruited into the same NMDA receptor and Shaker-type potassium channel clusters
UniProtKB/Swiss-Prot Function:
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
genes like me logo Genes that share phenotypes with DLG2: view

Animal Models for DLG2 Gene

MGI Knock Outs for DLG2:

miRNA for DLG2 Gene

miRTarBase miRNAs that target DLG2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLG2 Gene

Localization for DLG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLG2 Gene

Cell membrane; Lipid-anchor. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Membrane. Cell projection, axon. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250 UniProtKB:Q63622}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLG2 Gene COMPARTMENTS Subcellular localization image for DLG2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008076 colocalizes_with voltage-gated potassium channel complex ISS --
GO:0030054 cell junction IEA --
GO:0044224 juxtaparanode region of axon ISS --
genes like me logo Genes that share ontologies with DLG2: view

Pathways & Interactions for DLG2 Gene

genes like me logo Genes that share pathways with DLG2: view

Pathways by source for DLG2 Gene

1 Cell Signaling Technology pathway for DLG2 Gene
1 BioSystems pathway for DLG2 Gene
1 KEGG pathway for DLG2 Gene

Gene Ontology (GO) - Biological Process for DLG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0045197 NOT establishment or maintenance of epithelial cell apical/basal polarity IBA --
GO:0046710 GDP metabolic process TAS 8755482
GO:0097120 receptor localization to synapse IBA --
genes like me logo Genes that share ontologies with DLG2: view

No data available for SIGNOR curated interactions for DLG2 Gene

Drugs & Compounds for DLG2 Gene

(1) Drugs for DLG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DLG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLG2: view

Transcripts for DLG2 Gene

Unigene Clusters for DLG2 Gene

Discs, large homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4:
SP5:

ExUns: 24a · 24b ^ 25a · 25b
SP1: -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for DLG2 Gene

GeneLoc Exon Structure for
DLG2
ECgene alternative splicing isoforms for
DLG2

Expression for DLG2 Gene

mRNA expression in normal human tissues for DLG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLG2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Hippocampus (x4.9), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for DLG2 Gene

This gene is overexpressed in Brain (27.3), Frontal cortex (16.0), and Urine (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLG2 Gene



SOURCE GeneReport for Unigene cluster for DLG2 Gene Hs.367656

genes like me logo Genes that share expression patterns with DLG2: view

Protein tissue co-expression partners for DLG2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DLG2 Gene

Orthologs for DLG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLG2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DLG2 35
  • 94.34 (n)
  • 97.39 (a)
DLG2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlg2 35
  • 91.21 (n)
  • 96.78 (a)
Dlg2 16
Dlg2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLG2 35
  • 99.76 (n)
  • 99.69 (a)
DLG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlg2 35
  • 91.21 (n)
  • 96.66 (a)
cow
(Bos Taurus)
Mammalia DLG2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DLG2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLG2 35
  • 84.37 (n)
  • 92.94 (a)
DLG2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLG2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlg2 35
  • 80.8 (n)
  • 91.62 (a)
zebrafish
(Danio rerio)
Actinopterygii dlg2 35
  • 74.27 (n)
  • 86.41 (a)
dlg2 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dlg1 37
  • 61 (a)
dlg1 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dlg-1 37
  • 46 (a)
dlg-1 35
  • 51.24 (n)
  • 49.62 (a)
dlg-1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5033 36
  • 57 (a)
OneToMany
Species with no ortholog for DLG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLG2 Gene

ENSEMBL:
Gene Tree for DLG2 (if available)
TreeFam:
Gene Tree for DLG2 (if available)

Paralogs for DLG2 Gene

Paralogs for DLG2 Gene

genes like me logo Genes that share paralogs with DLG2: view

Variants for DLG2 Gene

Sequence variations from dbSNP and Humsavar for DLG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs519429 -- 85,297,061(+) TCTTA(C/T)GAGAA intron-variant
rs521517 -- 85,186,062(-) CATAG(C/T)TTAAT intron-variant
rs522231 -- 84,552,553(-) TGACC(G/T)CAGTC intron-variant
rs522604 -- 85,588,121(+) acagc(C/T)cttga intron-variant
rs522652 -- 85,283,493(-) TAATT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLG2 Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV Loss 17666407
esv8265 CNV Gain 19470904
esv270109 CNV Insertion 20981092
esv2589653 CNV Deletion 19546169
dgv228e199 CNV Deletion 23128226
esv1959476 CNV Deletion 18987734
esv22170 CNV Loss 19812545
esv2544219 CNV Loss 19546169
esv26008 CNV Loss 19812545
dgv1240n71 CNV Gain 21882294
dgv1241n71 CNV Gain 21882294
nsv898024 CNV Gain 21882294
nsv516859 CNV Loss 19592680
nsv468765 CNV Loss 19166990
esv2618406 CNV Deletion 19546169
nsv527778 CNV Loss 19592680
esv273492 CNV Insertion 20981092
esv269776 CNV Insertion 20981092
dgv1242n71 CNV Loss 21882294
esv267715 CNV Insertion 20981092
dgv1243n71 CNV Loss 21882294
nsv898029 CNV Loss 21882294
nsv898030 CNV Loss 21882294
esv2751034 CNV Gain 17911159
esv2744839 CNV Deletion 23290073
esv2661588 CNV Deletion 23128226
esv1421802 CNV Insertion 17803354
nsv513745 CNV Insertion 21212237
nsv516717 CNV Gain 19592680
esv2657838 CNV Deletion 23128226
esv2456833 CNV Deletion 19546169
esv270247 CNV Insertion 20981092
esv272606 CNV Insertion 20981092
esv1005592 CNV Insertion 20482838
nsv415 CNV Loss 18451855
esv8123 CNV Gain 19470904
nsv898031 CNV Loss 21882294
esv2664740 CNV Deletion 23128226
nsv524869 CNV Loss 19592680
nsv507605 CNV Insertion 20534489
esv6392 CNV Gain 19470904
nsv508642 CNV Loss 20534489
nsv519456 CNV Loss 19592680
nsv520103 CNV Loss 19592680
esv2744840 CNV Deletion 23290073
esv2740842 CNV Deletion 23290073
nsv468766 CNV Loss 19166990
nsv898032 CNV Loss 21882294
nsv898033 CNV Loss 21882294
nsv898034 CNV Loss 21882294
dgv1244n71 CNV Loss 21882294
nsv898036 CNV Loss 21882294
nsv519411 CNV Loss 19592680
nsv527928 CNV Gain 19592680
nsv898038 CNV Loss 21882294
nsv898039 CNV Loss 21882294
nsv898040 CNV Loss 21882294
nsv468767 CNV Loss 19166990
nsv8849 CNV Loss 18304495
esv2673432 CNV Deletion 23128226
nsv516146 CNV Loss 19592680
esv2744842 CNV Deletion 23290073
esv2744843 CNV Deletion 23290073
esv2744844 CNV Deletion 23290073
esv1506583 CNV Deletion 17803354
dgv408e1 CNV Complex 17122850
nsv510264 CNV Loss 20534489
nsv898041 CNV Loss 21882294
nsv482998 CNV Loss 15286789
esv273727 CNV Insertion 20981092
esv269387 CNV Insertion 20981092
esv2544867 CNV Deletion 19546169
esv2281631 CNV Deletion 18987734
esv2744845 CNV Deletion 23290073
esv987708 CNV Deletion 20482838
esv2673933 CNV Deletion 23128226
dgv75n21 CNV Loss 19592680
esv2744846 CNV Deletion 23290073
esv269724 CNV Insertion 20981092
esv2744847 CNV Deletion 23290073
nsv898042 CNV Loss 21882294
dgv1245n71 CNV Loss 21882294
esv2665612 CNV Deletion 23128226
esv2657415 CNV Deletion 23128226
nsv898045 CNV Loss 21882294
esv2622674 CNV Deletion 19546169
nsv898046 CNV Loss 21882294
dgv1246n71 CNV Loss 21882294
essv7704 CNV CNV 17122850
esv678 CNV CNV 17122850
nsv8850 CNV Loss 18304495
nsv898049 CNV Loss 21882294
nsv518780 CNV Loss 19592680
esv2471612 CNV Deletion 19546169
esv2202413 CNV Deletion 18987734
esv2657074 CNV Deletion 23128226
nsv416 CNV Insertion 18451855
dgv229e199 CNV Deletion 23128226
esv2421768 CNV Deletion 20811451
esv32962 CNV Loss 17666407
nsv515581 CNV Loss 19592680
esv2675105 CNV Deletion 23128226
esv2617997 CNV Deletion 19546169

Variation tolerance for DLG2 Gene

Residual Variation Intolerance Score: 2.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLG2 Gene

Human Gene Mutation Database (HGMD)
DLG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLG2 Gene

Disorders for DLG2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DLG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal oncocytoma
  • oncocytoma of kidney
bilateral retinoblastoma
chronic pain
  • pain - chronic
- elite association - COSMIC cancer census association via MalaCards
Search DLG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLG2

Genetic Association Database (GAD)
DLG2
Human Genome Epidemiology (HuGE) Navigator
DLG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLG2
genes like me logo Genes that share disorders with DLG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLG2 Gene

Publications for DLG2 Gene

  1. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (PMID: 8755482) Kim E. … Sheng M. (Neuron 1996) 2 3 4 67
  2. An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. (PMID: 15304517) Leyland M.L. … Dart C. (J. Biol. Chem. 2004) 3 23
  3. Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. (PMID: 12070168) Cai C. … KeinAonen K. (J. Biol. Chem. 2002) 3 23
  4. Fine-scale physical map of the 11q21 region surrounding the human DLG2 locus, the gene encoding Chapsyn-110. (PMID: 9806853) Stathakis D.G. … Bryant P.J. (Genomics 1998) 2 3
  5. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. (PMID: 9786987) Brenman J.E. … Bredt D.S. (J. Neurosci. 1998) 3 23

Products for DLG2 Gene

Sources for DLG2 Gene

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