DLG1 Gene
protein-coding GIFtS: 64
GCID: GC03M196769
|
|
discs, large homolog 1 (Drosophila)(Previous names: discs, large (Drosophila) homolog 1 )
| |
Aliases
for DLG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Discs, Large Homolog 1 (Drosophila)1 2 | | Synapse-Associated Protein 972 3 | | SAP-971 2 3 | | Discs, Large (Drosophila) Homolog 11 | | SAP971 2 3 | | Disks Large Homolog 12 | | DLGH11 2 | | Presynaptic Protein SAP972 | | DJ1061C18.1.11 | | HDlg1 | | Hdlg1 | | |
Export aliases for DLG1 gene to outside databasesPrevious GC identifers: GC03M192736 GC03M197118 GC03M198177 GC03M198097 GC03M198259 GC03M194068 |
Summaries
for DLG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DLG1:
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have arole in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, butthe full-length nature of some of the variants is not known. (provided by RefSeq, Feb 2011)
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Function: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels,receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherensjunction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates theexcitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator ofKv1.5 channel
Gene Wiki entry for DLG1
|
Genomic Views
for DLG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_029928.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DLG1 gene promoter:
Tal-1beta E47 NF-AT NF-AT4 NF-AT2 Hand1 NF-AT3 ITF-2 NF-kappaB1 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DLG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q29 Ensembl cytogenetic band: 3q29 HGNC cytogenetic band: 3q29DLG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M196769: view genomic region
(about GC identifiers)
Start:
|
196,769,431 bp from pter |
End:
|
197,026,171 bp from pter |
Size:
|
256,741 bases |
Orientation:
|
minus strand |
|
Proteins
for DLG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959 (See
protein sequence)Recommended Name: Disks large homolog 1 Size: 904 amino acids; 100455 Da
Subunit: Homotetramer (Probable). Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3,DLGAP4 and MAP1A. May interact with HTR2A (By similarity). Interacts with LRFN1 (By similarity). Interacts through itsPDZ domains with GRIN2A, KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, KCND2, KCND3, GRIA1, GPR124 and GPR125. Interacts withKCNF1. Interacts with CAMK2 (By similarity). Interacts with cytoskeleton-associated proteins EPB41 and EZR. Found in acomplex with KCNA5 and CAV3. Found in a complex with APC and CTNNB1. Interacts with CDH1 through binding to PIK3R1.Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12. Interacts through its guanylatekinase-like domain with KIF13B. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Mayinteract with TJAP1. Interacts with TOPK and the HTLV-1 viral Tax and HPV-18 E6 papillomavirus (HPV) oncoproteins.Interacts with PTEN (By similarity). Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2, LRFN4 andSFPQ
Subcellular location: Membrane; Peripheral membrane protein (By similarity). Basolateral cell membrane (By similarity).Endoplasmic reticulum membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynapticdensity (By similarity). Cell junction, synapse. Cell membrane, sarcolemma. Note=Colocalizes with EPB41 at regions ofintercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes.Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity)
6/8 PDB 3D structures from  and Proteopedia  for DLG1 (see all 8):1PDR (3D)
2OQS (3D)
2X7Z (3D)
3LRA (3D)
3RL7 (3D)
3RL8 (3D)
Secondary accessions: A5YKK7 B4DGU1 B4DGZ8 B7ZMM0 B9EIQ5 D3DXB8 D3DXB9 E7EWL7 E9PG21 Q12958Alternative splicing: 9 isoforms: Q12959-1 Q12959-2 Q12959-3 Q12959-4 Q12959-5 Q12959-6 Q12959-7 Q12959-8 Q12959-9 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DLG1: NX_Q12959
Post-translational modifications:
Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A. Isoform 2 is phosphorylated onSer-698. Isoform 3 is phosphorylated on Ser-665 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12959
DLG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001091894.1 NP_001191315.1 NP_001191316.1 NP_001191317.1 NP_004078.2
ENSEMBL proteins: ENSP00000345731 ENSP00000407531 ENSP00000398939 ENSP00000413238 ENSP00000391732 ENSP00000396658 ENSP00000376187 ENSP00000411278 ENSP00000396768 ENSP00000376186 ENSP00000398702 ENSP00000412579 ENSP00000396474 ENSP00000376185 ENSP00000414189 ENSP00000393771 ENSP00000390403 ENSP00000400169 ENSP00000350303 ENSP00000321087 Reactome Protein details: Q12959
Human Recombinant Protein Products:
Gene Ontology (GO): 5/27 cellular component terms (GO ID links to tree view) (see all 27): About this table
DLG1 for ontologies About GeneDecksing
DLG1 Antibody Products:
Assay Products for DLG1: |
Protein
Domains /
Families
for DLG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DLG1 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q12959ProtoNet protein and cluster: Q12959 3 Blocks protein families: IPB001452 SH3 domain signature IPB001478 PDZ/DHR/GLGF domain IPB008144 Guanylate kinase
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Domain: The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 bindingsite mediating association to membranes in polarized and non-polarized cellsDomain: The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27domain that binds CASK and DLG2Domain: The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable ofbinding several SH3 domains and also moderates the level of protein oligomerizationSimilarity: Belongs to the MAGUK familySimilarity: Contains 1 guanylate kinase-like domainSimilarity: Contains 1 L27 domainSimilarity: Contains 3 PDZ (DHR) domainsSimilarity: Contains 1 SH3 domain |
Function
for DLG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Function: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels,receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherensjunction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates theexcitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator ofKv1.5 channel Genatlas biochemistry entry for DLG1:Drosophila tumor suppressor gene,discs large (Dlg) homolog 1,involved in coupling the cytoskeleton to the cell membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLG1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLG1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 5): DLG1 (NM_004087) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DLG1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG1 |
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table
DLG1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DLG1:
Animal Models:
Mouse knock-outs for DLG1: Dlg1tm1.2Agri Dlg1tm1Taki Dlg1tm1Jhm
15/19 MGI mutant phenotypes (inferred from 8 alleles ) (MGI details for Dlg1) (see all 19):
DLG1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DLG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transmission across Chemical Synapses | | | 2 | Axon guidance | | | 3 | G beta:gamma signalling through PLC beta | | | 4 | Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | | | 5 | NrCAM interactions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for DLG1
3  BioSystems Pathways for DLG1
5/12 
Reactome Pathways for DLG1 (see all 12)
1 
Kegg Pathway (Kegg details for DLG1):
DLG1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DLG1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/144 Interacting proteins for DLG1 (Q129591, 2, 3 ENSP000003457314) via UniProtKB, MINT, STRING, and/or I2D (see all 144)About this table
Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001657 | ureteric bud development |
-- | -- | | GO:0001658 | branching involved in ureteric bud morphogenesis |
IEA | -- | | GO:0001771 | immunological synapse formation |
IEA | -- | | GO:0001935 | endothelial cell proliferation |
IDA | 14699157 | | GO:0002088 | lens development in camera-type eye |
IEA | -- |
DLG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DLG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DLG1 for compounds About GeneDecksing
 Browse Tocris compounds for DLG1
10/14 Novoseek chemical compound relationships for DLG1 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| guanylate |
85.6 |
41 |
9523702 (3), 8938729 (2), 9286858 (2), 11723125 (1) (see all 29) |
| nmda |
53.5 |
13 |
15929985 (2), 16957582 (1), 18233995 (1), 17156128 (1) (see all 10) |
| glutamate |
52.3 |
19 |
18665322 (3), 15044483 (2), 10939335 (1), 15657400 (1) (see all 13) |
| threonine |
33.9 |
5 |
10779557 (1), 14699157 (1), 9326658 (1), 10646847 (1) |
| valine |
22.4 |
1 |
9326658 (1) |
| kainate |
19.7 |
4 |
11279111 (3), 18665322 (1) |
| alanine |
18.5 |
2 |
17069616 (1), 16466689 (1) |
| phosphatidylinositol |
17.5 |
1 |
17314165 (1) |
| potassium |
14.9 |
8 |
15277200 (2), 11709425 (1), 9341123 (1), 18004877 (1) (see all 6) |
| leucine |
8.47 |
1 |
9326658 (1) |
Search CenterWatch for drugs/clinical trials and news about DLG1
|
Transcripts
for DLG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DLG1 gene (5 alternative transcripts): NM_001098424.1 NM_001204386.1 NM_001204387.1 NM_001204388.1 NM_004087.2 Unigene Cluster for DLG1: Discs, large homolog 1 (Drosophila) Hs.292549 [show with all ESTs]Unigene Representative Sequence: NM_00408718/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29): ENST00000346964(uc003fxo.4 uc003fxn.4 uc010ial.3) ENST00000469371
ENST00000419354 ENST00000452595(uc010ian.2) ENST00000422288 ENST00000448528
ENST00000443183 ENST00000392382 ENST00000450955 ENST00000475394 ENST00000470629
ENST00000419227(uc011buf.1) ENST00000392381(uc003fxp.2) ENST00000471733(uc010iam.1)
ENST00000493937 ENST00000447466 ENST00000477312 ENST00000453607
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLG1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLG1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): DLG1 (NM_004087) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DLG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG1 |
Additional cDNA sequence: AB209536.2 AK293967.1 AK294772.1 AK294855.1 AK310596.1 AK310893.1 AK311129.1 AL831922.1 BC015560.2 BC028486.1 BC037916.1 BC042118.1 BC140841.1 BC144651.1 EF553524.1 U13896.1 U13897.1 20 DOTS entries: DT.100770590 DT.455821 DT.86846298 DT.95376452 DT.100687155 DT.40251208 DT.120905530 DT.306676 DT.75134794 DT.100025509 DT.40216836 DT.92046140 DT.92434289 DT.40204665 DT.40293013 DT.65288186 DT.91862824 DT.91984033 DT.92051255 DT.92434290 24/228 AceView cDNA sequences (see all 228): AI815004 AA252116 BM681931 AA885039 AI144496 BX480920 AI864248 BX645639 AA436612 AA287392 BF445872 AA252522 N41990 BF589352 NM_004087 AI934918 AA825909 BM728664 BQ433661 N30267 AW296142 BM477099 AI358233 BQ014300
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DLG1 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DLG1
|
Expression
for DLG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DLG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DLG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DLG1
SOURCE GeneReport for Unigene cluster: Hs.292549
UniProtKB/Swiss-Prot: DLG1_HUMAN, Q12959Tissue specificity: Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts,cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expressionprofiles
SABiosciences Custom PCR Arrays for DLG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DLG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLG1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG1 |
Orthologs
for DLG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DLG1 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DLG11 |
discs, large homolog 1 (Drosophila) |
85.1(n)
93.84(a) |
|
424890 XM_422701.3 XP_422701.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DLG16 |
-- |
88(a) |
1 ↔ 1 |
AAWZ02036894(2336-4464) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.73682 |
Xenopus laevis transcribed sequence with moderate similarity more |
81.81(n) |
|
CA792773.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
dlg12 |
discs, large (Drosophila) homolog 1 |
75.96(n) |
|
114446 BC048066.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dlg11 , 3 |
establishment and/or maintenance of polarity
of more3
discs large 11 |
60(a)3
53.95(n)1
56.31(a)1 |
|
320831 NM_206683.31 NP_996406.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
dlg-11 , 3 |
guanylate kinase3
Protein DLG-11 |
45(a)3
51.35(n)1
48.6(a)1 |
|
X(5514745-5519401)3
1808191 NM_001029260.11 NP_001024431.11 |
ENSEMBL Gene Tree for DLG1 (if available)
TreeFam Gene Tree for DLG1 (if available) |
Paralogs
for DLG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DLG1 gene
- MPP62 MPP72 DLG32 MPP52 DLG22 MPP22 MPP42 DLG42
- CASK2 MPP12 MPP32
13 SIMAP similar genes for DLG1 using alignment to 13 protein entries: DLG1_HUMAN (see all proteins):DKFZp761P0818 DLG4 DLG2 DLG3 SYNJ2BP TJP2
LIN7C GUK1 DKFZp666F1010 TAX1BP3 CASK PDZD11
DKFZp666D023
DLG1 for paralogs About GeneDecksing
|
Genomic Variants
for DLG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DLG1 (196769431 - 197019431 bp, first 250kb of DLG1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for DLG1
11 CNVs: 36126 9465 29732 3473 31141 0043 59130 98594 68562 98593 53339
2 Inversions: 37243 0568 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLG1 |
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Disorders
/ Diseases
for DLG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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|
DLG1 for disorders About GeneDecksing
OMIM gene information: 601014
OMIM disorders: --
20/21  diseases for DLG1 (see all 21): About MalaCardshuman t-cell leukemia virus type 1 familial adenomatous polyposis fibrous histiocytoma adenomatous polyposis coli
malignant fibrous histiocytoma cervical intraepithelial neoplasia avian influenza histiocytoma
polyposis poliomyelitis cervical cancer t-cell leukemia
alzheimer's disease cervicitis influenza schizophrenia
leukemia carcinoma cerebritis retinitis
1 disease from the University of Copenhagen DISEASES database for DLG1:Cervical cancer 7 Novoseek disease relationships for DLG1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: DLG1 (7 documents)
Export disorders for DLG1 gene to outside databases
|
Publications
for DLG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DLG1 gene, integrated from 9 sources (see all 238):
(articles sorted by number of sources associating them with DLG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. (PubMed id 7937897)1, 2, 3 Lue R.A.... Chishti A.H. (1994)
- Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. (PubMed id 19213956)1, 2, 9 El-Haou S.... Hatem S.N. (2009)
- Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. (PubMed id 15021905)1, 2, 9 Yamamoto Y.... Takai Y. (2004)
- Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. (PubMed id 14699157)1, 2, 9 Laprise P.... Rivard N. (2004)
- Protein 4.1-mediated membrane targeting of human discs large in epithelial cells. (PubMed id 12807908)1, 2, 9 Hanada T.... Chishti A.H. (2003)
- The distribution and function of alternatively spliced insertions in hDlg. (PubMed id 11723125)1, 2, 9 McLaughlin M.... Viel A. (2002)
- Characterization of PDZ-binding kinase, a mitotic kinase. (PubMed id 10779557)1, 2, 9 Gaudet S.... Lue R.A. (2000)
- Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain. (PubMed id 8922391)1, 2, 9 Lue R.A.... Branton D. (1996)
- GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. (PubMed id 10859302)1, 2, 9 Hanada T.... Chishti A.H. (2000)
- The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. (PubMed id 10656683)1, 2, 9 Ishidate T.... Akiyama T. (2000)
|
External Searches for DLG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing DLG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DLG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DLG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DLG1 gene:
Search GeneIP for patents involving DLG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DLG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for DLG1 | | OriGene shRNA RFP for DLG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DLG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DLG1 | | | OriGene Protein Over-expression Lysate for DLG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DLG1 | | OriGene 3'-UTR Clone for DLG1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DLG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DLG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DLG1 | | OriGene Custom Protein Services for DLG1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DLG1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLG1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLG1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DLG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DLG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DLG1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLG1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLG1 |
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