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Aliases for DLEU7 Gene

Aliases for DLEU7 Gene

  • Deleted In Lymphocytic Leukemia, 7 2 3 5
  • Deleted In Lymphocytic Leukemia 7 4
  • LEU7 4

External Ids for DLEU7 Gene

Previous GeneCards Identifiers for DLEU7 Gene

  • GC13M049195
  • GC13M049084
  • GC13M050184
  • GC13M051288
  • GC13M032075

Summaries for DLEU7 Gene

GeneCards Summary for DLEU7 Gene

DLEU7 (Deleted In Lymphocytic Leukemia, 7) is a Protein Coding gene.

Additional gene information for DLEU7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLEU7 Gene

Genomics for DLEU7 Gene

Regulatory Elements for DLEU7 Gene

Enhancers for DLEU7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H050908 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -69.2 -69175 10 HDGF FOXA2 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 RNASEH2B RNASEH2B-AS1 DLEU7-AS1 DLEU7 KCNRG INTS6 GC13M050919
GH13H050890 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -49.1 -49096 4.9 MAX BATF POLR2A EED RCOR1 RUNX3 IKZF2 CREM MAZ ZNF687 RNASEH2B-AS1 RNASEH2B DLEU7 DLEU7-AS1 KCNRG GC13P050857
GH13H050592 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +249.3 249291 4.4 ELF3 PKNOX1 TBL1XR1 RB1 INSM2 FEZF1 THRB ATF7 RUNX3 IKZF2 DLEU7 EBPL RNASEH2B GC13P050590 GC13P050648
GH13H050675 1 Ensembl ENCODE 14.8 +165.9 165909 4.6 PKNOX1 ATF1 ZFP64 BACH1 EBF1 CEBPG FOSL1 ZFHX2 GATA3 POLR2A DLEU7 EBPL GC13P050653 GC13P050713
GH13H050207 1.5 FANTOM5 Ensembl ENCODE 9.6 +634.9 634919 2.2 PKNOX1 ARNT GLI4 GLIS2 ATF7 SMARCA4 GLIS1 NBN HMBOX1 SP7 SETDB2 RPL34P26 RNASEH2B TRIM13 DLEU7 EBPL GC13P050221 GC13P050185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DLEU7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DLEU7 Gene

Genomic Locations for DLEU7 Gene
chr13:50,695,550-50,843,939
(GRCh38/hg38)
Size:
148,390 bases
Orientation:
Minus strand
chr13:51,285,144-51,418,075
(GRCh37/hg19)

Genomic View for DLEU7 Gene

Genes around DLEU7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEU7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEU7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEU7 Gene

Proteins for DLEU7 Gene

  • Protein details for DLEU7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UYE1-LEU7_HUMAN
    Recommended name:
    Leukemia-associated protein 7
    Protein Accession:
    Q6UYE1
    Secondary Accessions:
    • Q2M2E4
    • Q6ZT82

    Protein attributes for DLEU7 Gene

    Size:
    221 amino acids
    Molecular mass:
    23924 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLEU7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLEU7 Gene

Post-translational modifications for DLEU7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLEU7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLEU7 Gene

Domains & Families for DLEU7 Gene

Gene Families for DLEU7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DLEU7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DLEU7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLEU7: view

No data available for UniProtKB/Swiss-Prot for DLEU7 Gene

Function for DLEU7 Gene

Phenotypes From GWAS Catalog for DLEU7 Gene

genes like me logo Genes that share phenotypes with DLEU7: view

Animal Models for DLEU7 Gene

MGI Knock Outs for DLEU7:

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DLEU7 Gene

Localization for DLEU7 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DLEU7 Gene

Pathways & Interactions for DLEU7 Gene

SuperPathways for DLEU7 Gene

No Data Available

Interacting Proteins for DLEU7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000420976%0d%0a9606.ENSP00000269886%0d%0a
Selected Interacting proteins: ENSP00000420976 for DLEU7 Gene via STRING

Symbol External ID(s) Details
SH3GL1

Gene Ontology (GO) - Biological Process for DLEU7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DLEU7 Gene

Drugs & Compounds for DLEU7 Gene

No Compound Related Data Available

Transcripts for DLEU7 Gene

mRNA/cDNA for DLEU7 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DLEU7 Gene

Deleted in lymphocytic leukemia, 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU7 Gene

No ASD Table

Relevant External Links for DLEU7 Gene

GeneLoc Exon Structure for
DLEU7
ECgene alternative splicing isoforms for
DLEU7

Expression for DLEU7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLEU7 Gene

mRNA differential expression in normal tissues according to GTEx for DLEU7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cortex (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLEU7 Gene



NURSA nuclear receptor signaling pathways regulating expression of DLEU7 Gene:

DLEU7

SOURCE GeneReport for Unigene cluster for DLEU7 Gene:

Hs.710878

mRNA Expression by UniProt/SwissProt for DLEU7 Gene:

Q6UYE1-LEU7_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DLEU7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DLEU7 Gene

Orthologs for DLEU7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DLEU7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLEU7 33 34
  • 100 (n)
rat
(Rattus norvegicus)
Mammalia Dleu7 33
  • 83.58 (n)
mouse
(Mus musculus)
Mammalia Dleu7 33 16 34
  • 83.33 (n)
cow
(Bos Taurus)
Mammalia DLEU7 33
  • 81.86 (n)
oppossum
(Monodelphis domestica)
Mammalia DLEU7 34
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLEU7 33 34
  • 50.8 (n)
zebrafish
(Danio rerio)
Actinopterygii DLEU7 34
  • 17 (a)
OneToOne
Species where no ortholog for DLEU7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLEU7 Gene

ENSEMBL:
Gene Tree for DLEU7 (if available)
TreeFam:
Gene Tree for DLEU7 (if available)

Paralogs for DLEU7 Gene

No data available for Paralogs for DLEU7 Gene

Variants for DLEU7 Gene

Sequence variations from dbSNP and Humsavar for DLEU7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000017927 -- 50,800,841(+) GGACT(C/T)TTCTG intron-variant
rs1000023871 -- 50,784,235(+) TATTA(A/G)AGAAG intron-variant
rs1000074150 -- 50,821,492(+) ATTAA(A/G)ATATC intron-variant, nc-transcript-variant
rs1000103001 -- 50,820,935(+) TAATA(A/C)GTTTT intron-variant, nc-transcript-variant
rs1000145862 -- 50,821,740(+) AAAAA(-/AAC)AAAAA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DLEU7 Gene

Variant ID Type Subtype PubMed ID
nsv561643 CNV loss 21841781
nsv561618 CNV loss 21841781
nsv437786 CNV loss 16327808
nsv1037350 CNV loss 25217958
esv3580637 CNV loss 25503493
esv3335461 CNV insertion 20981092
esv2593545 CNV deletion 19546169

Variation tolerance for DLEU7 Gene

Gene Damage Index Score: 5.48; 71.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLEU7 Gene

Human Gene Mutation Database (HGMD)
DLEU7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLEU7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEU7 Gene

Disorders for DLEU7 Gene

Relevant External Links for DLEU7

Genetic Association Database (GAD)
DLEU7
Human Genome Epidemiology (HuGE) Navigator
DLEU7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLEU7

No disorders were found for DLEU7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLEU7 Gene

Publications for DLEU7 Gene

  1. Characterization of a novel B-CLL candidate gene--DLEU7--located in the 13q14 tumor suppressor locus. (PMID: 14706829) Hammarsund M … Grandér D (FEBS letters 2004) 2 3 4 60
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 45 60
  3. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PMID: 19266077) Sovio U … Jarvelin MR (PLoS genetics 2009) 3 45 60
  4. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N … Deloukas P (PLoS genetics 2009) 3 45 60
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 45 60

Products for DLEU7 Gene

Sources for DLEU7 Gene

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