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Aliases for DLEU7 Gene

Aliases for DLEU7 Gene

  • Deleted In Lymphocytic Leukemia, 7 2 3 5
  • Deleted In Lymphocytic Leukemia 7 4
  • LEU7 4

External Ids for DLEU7 Gene

Previous GeneCards Identifiers for DLEU7 Gene

  • GC13M049195
  • GC13M049084
  • GC13M050184
  • GC13M051288
  • GC13M032075

Summaries for DLEU7 Gene

GeneCards Summary for DLEU7 Gene

DLEU7 (Deleted In Lymphocytic Leukemia, 7) is a Protein Coding gene. Diseases associated with DLEU7 include Hepatocellular Fibrolamellar Carcinoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLEU7 Gene

Genomics for DLEU7 Gene

Regulatory Elements for DLEU7 Gene

Enhancers for DLEU7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DLEU7 on UCSC Golden Path with GeneCards custom track

Promoters for DLEU7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLEU7 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLEU7 Gene

50,695,550 bp from pter
50,843,939 bp from pter
148,390 bases
Minus strand

Genomic View for DLEU7 Gene

Genes around DLEU7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEU7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEU7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEU7 Gene

Proteins for DLEU7 Gene

  • Protein details for DLEU7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukemia-associated protein 7
    Protein Accession:
    Secondary Accessions:
    • Q2M2E4
    • Q6ZT82

    Protein attributes for DLEU7 Gene

    221 amino acids
    Molecular mass:
    23924 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DLEU7 Gene


neXtProt entry for DLEU7 Gene

Post-translational modifications for DLEU7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLEU7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DLEU7 Gene

Domains & Families for DLEU7 Gene

Protein Domains for DLEU7 Gene


Suggested Antigen Peptide Sequences for DLEU7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLEU7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DLEU7 Gene

Function for DLEU7 Gene

genes like me logo Genes that share phenotypes with DLEU7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DLEU7 Gene

Localization for DLEU7 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DLEU7 Gene

Pathways & Interactions for DLEU7 Gene

SuperPathways for DLEU7 Gene

No Data Available

Interacting Proteins for DLEU7 Gene

Gene Ontology (GO) - Biological Process for DLEU7 Gene


No data available for Pathways by source and SIGNOR curated interactions for DLEU7 Gene

Drugs & Compounds for DLEU7 Gene

No Compound Related Data Available

Transcripts for DLEU7 Gene

mRNA/cDNA for DLEU7 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DLEU7 Gene

Deleted in lymphocytic leukemia, 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU7 Gene

No ASD Table

Relevant External Links for DLEU7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLEU7 Gene

mRNA expression in normal human tissues for DLEU7 Gene

mRNA differential expression in normal tissues according to GTEx for DLEU7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cortex (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLEU7 Gene

NURSA nuclear receptor signaling pathways regulating expression of DLEU7 Gene:


SOURCE GeneReport for Unigene cluster for DLEU7 Gene:


mRNA Expression by UniProt/SwissProt for DLEU7 Gene:

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DLEU7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for DLEU7 Gene

Orthologs for DLEU7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DLEU7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DLEU7 34
  • 81.86 (n)
  • 71.23 (a)
(Mus musculus)
Mammalia Dleu7 34
  • 83.33 (n)
  • 83.82 (a)
Dleu7 16
Dleu7 35
  • 58 (a)
(Pan troglodytes)
Mammalia DLEU7 34
  • 100 (n)
  • 100 (a)
DLEU7 35
  • 71 (a)
(Rattus norvegicus)
Mammalia Dleu7 34
  • 83.58 (n)
  • 85.29 (a)
(Monodelphis domestica)
Mammalia DLEU7 35
  • 36 (a)
(Gallus gallus)
Aves DLEU7 34
  • 50.8 (n)
  • 39.31 (a)
DLEU7 35
  • 27 (a)
(Danio rerio)
Actinopterygii DLEU7 35
  • 17 (a)
Species where no ortholog for DLEU7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLEU7 Gene

Gene Tree for DLEU7 (if available)
Gene Tree for DLEU7 (if available)

Paralogs for DLEU7 Gene

No data available for Paralogs for DLEU7 Gene

Variants for DLEU7 Gene

Sequence variations from dbSNP and Humsavar for DLEU7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_031280 -
rs111932 -- 50,760,002(-) TGGAA(C/G)CAGGT intron-variant
rs111933 -- 50,759,929(-) GAAGG(A/G)AGGGT intron-variant
rs476444 -- 50,753,294(-) tggcg(C/T)gggac intron-variant
rs487601 -- 50,758,660(-) CCTCT(G/T)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLEU7 Gene

Variant ID Type Subtype PubMed ID
esv2593545 CNV deletion 19546169
esv3335461 CNV insertion 20981092
esv3580637 CNV loss 25503493
nsv1037350 CNV loss 25217958
nsv437786 CNV loss 16327808
nsv561618 CNV loss 21841781
nsv561643 CNV loss 21841781

Variation tolerance for DLEU7 Gene

Gene Damage Index Score: 5.48; 71.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLEU7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEU7 Gene

Disorders for DLEU7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DLEU7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hepatocellular fibrolamellar carcinoma
  • fibrolamellar hepatocellular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search DLEU7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLEU7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DLEU7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLEU7 Gene

Publications for DLEU7 Gene

  1. Characterization of a novel B-CLL candidate gene -- DLEU7 -- located in the 13q14 tumor suppressor locus. (PMID: 14706829) Hammarsund M. … Grander D. (FEBS Lett. 2004) 2 3 4 65
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 65
  3. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PMID: 19266077) Sovio U. … Jarvelin M.R. (PLoS Genet. 2009) 3 46 65
  4. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N. … Deloukas P. (PLoS Genet. 2009) 3 46 65
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 65

Products for DLEU7 Gene

Sources for DLEU7 Gene