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Aliases for DLEU1 Gene

Subcategory (RNA class) for DLEU1 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for DLEU1 Gene

  • Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding) 2 3 5
  • B-Cell Neoplasia-Associated Gene With Multiple Splicing 2 3
  • Long Intergenic Non-Protein Coding RNA 21 2 3
  • LEU1 3 4
  • XTP6 3 4
  • HBV X-Transactivated Gene 6 Protein 4
  • Deleted In Lymphocytic Leukemia, 1 2
  • Deleted In Lymphocytic Leukemia 1 4
  • HBV XAg-Transactivated Protein 6 4
  • Leukemia-Associated Protein 2 3
  • Non-Protein Coding RNA 21 2
  • NCRNA00021 3
  • LINC00021 3
  • BCMS1 3
  • DLEU2 3
  • Leu2 3
  • BCMS 3
  • DLB1 3

External Ids for DLEU1 Gene

Previous HGNC Symbols for DLEU1 Gene

  • DLB1
  • BCMS

Previous GeneCards Identifiers for DLEU1 Gene

  • GC13P048656
  • GC13P044643
  • GC13P049592
  • GC13P048454
  • GC13P049554
  • GC13P050656
  • GC13P031451

Summaries for DLEU1 Gene

GeneCards Summary for DLEU1 Gene

DLEU1 (Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

UniProtKB/Swiss-Prot for DLEU1 Gene

  • May act as a tumor suppressor.

Gene Wiki entry for DLEU1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLEU1 Gene

Genomics for DLEU1 Gene

Regulatory Elements for DLEU1 Gene

Transcription factor binding sites by QIAGEN in the DLEU1 gene promoter:

Genomic Location for DLEU1 Gene

50,082,169 bp from pter
50,723,236 bp from pter
641,068 bases
Plus strand

Genomic View for DLEU1 Gene

Genes around DLEU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEU1 Gene

Proteins for DLEU1 Gene

  • Protein details for DLEU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukemia-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q547G6
    • Q8TE10
    • Q96QY5

    Protein attributes for DLEU1 Gene

    78 amino acids
    Molecular mass:
    8962 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA75515.1; Type=Frameshift; Positions=73; Evidence={ECO:0000305};

neXtProt entry for DLEU1 Gene

Proteomics data for DLEU1 Gene at MOPED

Post-translational modifications for DLEU1 Gene

No Post-translational modifications

Other Protein References for DLEU1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for DLEU1 Gene

Domains & Families for DLEU1 Gene

Gene Families for DLEU1 Gene

Protein Domains for DLEU1 Gene


Suggested Antigen Peptide Sequences for DLEU1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLEU1: view

No data available for UniProtKB/Swiss-Prot for DLEU1 Gene

Function for DLEU1 Gene

Molecular function for DLEU1 Gene

UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor.

Phenotypes for DLEU1 Gene

GenomeRNAi human phenotypes for DLEU1:
genes like me logo Genes that share phenotypes with DLEU1: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DLEU1 Gene

Localization for DLEU1 Gene

Subcellular locations from

Jensen Localization Image for DLEU1 Gene COMPARTMENTS Subcellular localization image for DLEU1 gene
Compartment Confidence
extracellular 3
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DLEU1 Gene

Pathways & Interactions for DLEU1 Gene

SuperPathways for DLEU1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DLEU1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DLEU1 Gene

Drugs & Compounds for DLEU1 Gene

No Compound Related Data Available

Transcripts for DLEU1 Gene

Unigene Clusters for DLEU1 Gene

Deleted in lymphocytic leukemia 1 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU1 Gene

No ASD Table

Relevant External Links for DLEU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLEU1 Gene

mRNA expression in normal human tissues for DLEU1 Gene

SOURCE GeneReport for Unigene cluster for DLEU1 Gene Hs.591229

genes like me logo Genes that share expression patterns with DLEU1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DLEU1 Gene

Orthologs for DLEU1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DLEU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DLEU1 36
  • 99 (a)
Species with no ortholog for DLEU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DLEU1 Gene

Gene Tree for DLEU1 (if available)
Gene Tree for DLEU1 (if available)

Paralogs for DLEU1 Gene

No data available for Paralogs for DLEU1 Gene

Variants for DLEU1 Gene

Sequence variations from dbSNP and Humsavar for DLEU1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs118480 -- 50,401,056(-) catgg(C/G)ctaag intron-variant
rs123378 -- 50,514,673(-) CCTTT(A/C/T)CTGAT intron-variant
rs149340 -- 50,486,908(-) CTTCT(A/C)GCTTT intron-variant
rs149845 -- 50,378,654(-) ACTAG(A/G)GCCAC intron-variant
rs149846 -- 50,392,777(-) GCATA(C/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLEU1 Gene

Variant ID Type Subtype PubMed ID
nsv832608 CNV Gain 17160897

Variation tolerance for DLEU1 Gene

Gene Damage Index Score: 5.09; 69.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLEU1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEU1 Gene

Disorders for DLEU1 Gene

Relevant External Links for DLEU1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DLEU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLEU1 Gene

Publications for DLEU1 Gene

  1. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PMID: 9395242) Liu Y. … Oscier D. (Oncogene 1997) 2 3 4 23 67
  2. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. (PMID: 11406609) Wolf S. … Lichter P. (Hum. Mol. Genet. 2001) 2 3
  3. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PMID: 11161783) Kapanadze B. … Sangfelt O. (Genomics 2000) 3 23
  4. Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. (PMID: 23593011) Garding A. … Mertens D. (PLoS Genet. 2013) 3
  5. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M. … Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012) 3

Products for DLEU1 Gene

Sources for DLEU1 Gene

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