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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DLEU1 Gene

RNA gene   GIFtS: 40
GCID: GC13P050656

Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding)

(Previous names: deleted in lymphocytic leukemia, 1)
(Previous symbols: DLB1, BCMS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 10

Aliases
Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding)1 2     Non-Protein Coding RNA 211
LEU12 3 5     DLEU22
BCMS1 2     LEU22
DLB11 2     LINC000212
XTP62 3     NCRNA000212
B-Cell Neoplasia-Associated Gene With Multiple Splicing1     Deleted In Lymphocytic Leukemia 13
Deleted In Lymphocytic Leukemia, 11     HBV X-Transactivated Gene 6 Protein3
Long Intergenic Non-Protein Coding RNA 211     HBV XAg-Transactivated Protein 63

External Ids:    HGNC: 137471   Entrez Gene: 103012   Ensembl: ENSG000001761247   OMIM: 6057655   UniProtKB: O432613   
ORGUL members:    fRNAdb10:FR162557 FR063253 FR314868 FR023517 FR001451      
H-InvDB12:HIT000247600 HIT000247610 HIT000247591 HIT000247585    
NCBI13:AJ412058 AJ412019 AJ411992 AJ412000 AJ412056 see all 55    
NONCODE14:n373557 n373560 n382042 n386051 n386054 see all 31      
RNAdb15:LIT1875 LIT1936 LIT1973 LIT1965 LIT1884 see all 58    

Export aliases for DLEU1 gene to outside databases

Previous GC identifers: GC13P048656 GC13P044643 GC13P049592 GC13P048454 GC13P049554 GC13P031451


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DLEU1 Gene: 
DLEU1 (deleted in lymphocytic leukemia 1 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with DLEU1 include sezary's disease, and b-cell chronic lymphocytic leukemia.

UniProtKB/Swiss-Prot: LEU1_HUMAN, O43261
Function: May act as a tumor suppressor

Gene Wiki entry for DLEU1 Gene

fRNAdb sequence ontologies for DLEU1 - the ORGUL cluster for this gene includes several descriptions:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for DLEU1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DLEU1 gene promoter:
         AML1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DLEU1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLEU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.3

DLEU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLEU1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P050656:  view genomic region     (about GC identifiers)

Start:
50,656,307 bp from pter      End:
51,297,372 bp from pter
Size:
641,066 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DLEU1

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LEU1_HUMAN, O43261 (See protein sequence)
Recommended Name: Leukemia-associated protein 1  
Size: 78 amino acids; 8962 Da
Sequence caution: Sequence=CAA75515.1; Type=Frameshift; Positions=73;
Secondary accessions: Q547G6 Q8TE10 Q96QY5

Explore the universe of human proteins at neXtProt for DLEU1: NX_O43261

DLEU1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

ENSEMBL proteins: 
 ENSP00000367422  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: O43261


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LEU1_HUMAN, O43261
Function: May act as a tumor suppressor

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
DLEU1 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DLEU1

5/28 Interacting proteins for DLEU1 (O432611, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
KAT5Q929931, 2, 3EBI-710057,EBI-399080 MINT-63124 I2D: score=3 
ABCF3Q9NUQ82, 3MINT-63125 I2D: score=3 
CCDC90BQ9GZT62, 3MINT-63127 I2D: score=3 
COPS6Q7L5N12, 3MINT-63121 I2D: score=3 
EEF1GP266412, 3MINT-63116 I2D: score=3 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DLEU1 (LEU1)

Search CenterWatch for drugs/clinical trials and news about DLEU1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
5/38 fRNAdb Secondary structures (see all 38):


REFSEQ mRNAs for DLEU1 gene: 
NM_005887.1  

Unigene Clusters for DLEU1:

Deleted in lymphocytic leukemia 1 (non-protein coding)
Hs.591229  [show with all ESTs], Hs.712880  [show with all ESTs]
Unigene Representative Sequences: AK095311, AJ412031
18/35 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
ENST00000478860 ENST00000378180(uc001vec.3) ENST00000469754(uc001ved.3)
ENST00000486895(uc010adl.1) ENST00000461527(uc001vee.1) ENST00000463474(uc010adn.1)
ENST00000476738(uc010adm.1) ENST00000468168(uc001vef.1) ENST00000491341(uc010ado.1)
ENST00000468522(uc010adp.1) ENST00000491615(uc001veg.1 uc001vei.1)
ENST00000490577 ENST00000467721(uc010tgn.1) ENST00000484529(uc001vek.1)
ENST00000475913(uc001vel.1) ENST00000485007(uc001vem.1) ENST00000473075(uc001ven.1)
ENST00000483444
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AJ412026.1 AJ412027.1 AJ412028.1 AJ412030.1 AJ412031.1 AJ412032.1 AJ412033.1 AJ412034.1 
AJ412035.1 AJ412036.1 AJ412037.1 AJ412041.1 AJ412042.1 AJ412043.1 AJ412044.1 AJ412045.1 
AJ412046.1 AJ412049.1 AJ412050.1 AJ412051.1 AJ412052.1 AJ412053.1 AJ412055.1 AJ412056.1 
AJ412057.1 AJ412058.1 AJ412059.1 AJ412063.1 

21 DOTS entries:

DT.92325323  DT.100888852  DT.455546  DT.120775026  DT.120774920  DT.95283746  DT.95283752  DT.120774773 
DT.120774943  DT.75109265  DT.91714567  DT.95143444  DT.95283742  DT.95283743  DT.95283745  DT.95283748 
DT.95283759  DT.40119497  DT.75146171  DT.95283744  DT.70104168 

24/145 AceView cDNA sequences (see all 145):

BU660035 AJ412053 AF490255 BM725594 AA418735 AW089770 AJ412056 BQ575432 
BU071717 AJ412040 AW136497 CR605740 AJ412051 BC020692 AA479324 CR450325 
AJ412048 BU787701 AA478587 AA258715 BM678069 BX106695 AK095311 CB156083 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for DLEU1:RNAdb

DLEU1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAAAGCCCA
DLEU1 Expression
About this image


Genevestigator expression for DLEU1

SOURCE GeneReport for Unigene clusters: Hs.591229 Hs.712880
    SABiosciences Custom PCR Arrays for DLEU1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLEU1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for DLEU1 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia DLEU16
deleted in lymphocytic leukemia 1 (non-protein cod...
99(a)
1 ↔ 1
13(49807119-49830676)


ENSEMBL Gene Tree for DLEU1 (if available)
TreeFam Gene Tree for DLEU1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 1 variation for DLEU1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv832608CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605765OMIM information: 605766    
5 diseases for DLEU1:    About MalaCards
sezary's disease    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia    leukemia
multiple sclerosis


DLEU1 for disorders           About GeneDecksing

Genetic Association Database (GAD): DLEU1
Human Genome Epidemiology (HuGE) Navigator: DLEU1 (2 documents)

Export disorders for DLEU1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DLEU1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DLEU1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PubMed id 9395242)1, 2, 3, 9 Liu Y.... Oscier D. (1997)
  2. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PubMed id 11161783)1, 2, 9 Kapanadze B....Sangfelt O. (2000)
  3. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (2009)
  4. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. (PubMed id 11406609)1, 3 Wolf S....Lichter P. (2001)
  5. Epigenetic upregulation of lncRNAs at 13q14.3 in leuke mia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. (PubMed id 23593011)1 Garding A....Mertens D. (2013)
  6. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (2011)
  7. Chronic lymphocytic leukemia and 13q14: miRs and more . (PubMed id 19347735)1 Mertens D....Stilgenbauer S. (2009)
  8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
  9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10301 HGNC: 13747 AceView: DLEU1 Ensembl:ENSG00000176124 euGenes: HUgn10301
ECgene: DLEU1 H-InvDB: DLEU1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DLEU1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DLEU1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DLEU1 gene:
Search GeneIP for patents involving DLEU1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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