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DLEU1 Gene

RNA gene   GIFtS: 40
GCID: GC13P050656

Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding)

(Previous names: deleted in lymphocytic leukemia, 1)
(Previous symbols: DLB1, BCMS)
  See DLEU1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 5.4

Aliases
Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding)1 2     Non-Protein Coding RNA 211
LEU12 3 5     DLEU22
BCMS1 2     LEU22
DLB11 2     LINC000212
XTP62 3     NCRNA000212
B-Cell Neoplasia-Associated Gene With Multiple Splicing1     Deleted In Lymphocytic Leukemia 13
Deleted In Lymphocytic Leukemia, 11     HBV X-Transactivated Gene 6 Protein3
Long Intergenic Non-Protein Coding RNA 211     HBV XAg-Transactivated Protein 63

External Ids:    HGNC: 137471   Entrez Gene: 103012   Ensembl: ENSG000001761247   OMIM: 6057655   UniProtKB: O432613   
ORGUL members:    fRNAdb10:FR286397 FR354097 FR080696 FR162557 FR078270      
H-InvDB12:HIT000247600 HIT000247610 HIT000247591 HIT000247585    
NCBI13:AJ412001 AJ412015 AJ412007 AJ412058 AJ412019 see all 85    
NONCODE14:n344808 n373557 n373560 n382039 n382042 see all 31    
RNAdb15:LIT1964 LIT1944 LIT1955 LIT1875 RNZ9983 see all 104    

Export aliases for DLEU1 gene to outside databases

Previous GC identifers: GC13P048656 GC13P044643 GC13P049592 GC13P048454 GC13P049554 GC13P031451


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DLEU1 Gene:
DLEU1 (deleted in lymphocytic leukemia 1 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with DLEU1 include b-cell chronic lymphocytic leukemia, and chronic lymphocytic leukemia.

UniProtKB/Swiss-Prot: LEU1_HUMAN, O43261
Function: May act as a tumor suppressor

Gene Wiki entry for DLEU1 Gene

fRNAdb sequence ontologies for DLEU1 - the ORGUL cluster for this gene includes several descriptions:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for DLEU1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the DLEU1 gene promoter:
         AML1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DLEU1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLEU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.3

DLEU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLEU1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P050656:  view genomic region     (about GC identifiers)

Start:
50,656,307 bp from pter      End:
51,297,372 bp from pter
Size:
641,066 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DLEU1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: LEU1_HUMAN, O43261 (See protein sequence)
Recommended Name: Leukemia-associated protein 1  
Size: 78 amino acids; 8962 Da
Sequence caution: Sequence=CAA75515.1; Type=Frameshift; Positions=73;
Secondary accessions: Q547G6 Q8TE10 Q96QY5

Explore the universe of human proteins at neXtProt for DLEU1: NX_O43261


ENSEMBL proteins: 
 ENSP00000367422  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: O43261


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LEU1_HUMAN, O43261
Function: May act as a tumor suppressor

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with DLEU1           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol1
endoplasmic reticulum1
mitochondrion1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DLEU1
Interactions:

    Search GeneGlobe Interaction Network for DLEU1

Selected Interacting proteins for DLEU1 (O432611, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
KAT5Q929931, 2, 3EBI-710057,EBI-399080 MINT-63124 I2D: score=3 
ABCF3Q9NUQ82, 3MINT-63125 I2D: score=3 
CCDC90BQ9GZT62, 3MINT-63127 I2D: score=3 
COPS6Q7L5N12, 3MINT-63121 I2D: score=3 
EEF1GP266412, 3MINT-63116 I2D: score=3 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DLEU1 (LEU1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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5/77 fRNAdb Secondary structures (see all 77):


REFSEQ mRNAs for DLEU1 gene: 
NM_005887.1  

Unigene Cluster for DLEU1:

Deleted in lymphocytic leukemia 1 (non-protein coding)
Hs.591229  [show with all ESTs]
Unigene Representative Sequence: AK095311
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
ENST00000478860 ENST00000378180(uc001vec.3) ENST00000469754(uc001ved.3)
ENST00000486895(uc010adl.1) ENST00000461527(uc001vee.1) ENST00000463474(uc010adn.1)
ENST00000476738(uc010adm.1) ENST00000468168(uc001vef.1) ENST00000491341(uc010ado.1)
ENST00000468522(uc010adp.1) ENST00000491615(uc001veg.1 uc001vei.1)
ENST00000490577 ENST00000467721(uc010tgn.1) ENST00000484529(uc001vek.1)
ENST00000475913(uc001vel.1) ENST00000485007(uc001vem.1) ENST00000473075(uc001ven.1)
ENST00000483444
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Additional mRNA sequence: 

AF490255.1 AJ412023.1 AJ412024.1 AJ412025.1 AJ412038.1 AJ412039.1 AJ412054.1 AJ412061.1 
AJ412062.1 AK095311.1 AK312167.1 BC020692.1 CR450325.1 NR_002605.1 Y15227.1 

9 DOTS entries:

DT.92325323  DT.100888852  DT.455546  DT.120775026  DT.120774920  DT.95143444  DT.95283742  DT.95283743 
DT.70104168 

Selected AceView cDNA sequences (see all 145):

BM725594 AW089770 BE504299 AJ412046 AL558390 BM678069 AA425755 BU071717 
CB156083 AK095311 BU660035 BQ575432 BX106695 AF490255 AJ412063 CR600970 
AJ412053 AA478587 AJ412056 AJ412042 AA258715 AJ412040 AW136497 CR605740 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for DLEU1:RNAdb

DLEU1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAAAGCCCA
DLEU1 Expression
About this image

DLEU1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.591229
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for DLEU1 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia DLEU16
deleted in lymphocytic leukemia 1 (non-protein cod...
99(a)
1 ↔ 1
13(49807119-49830676)


ENSEMBL Gene Tree for DLEU1 (if available)
TreeFam Gene Tree for DLEU1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 1 variation for DLEU1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832608CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605765OMIM information: 605766 610879 603076 607784 605184 607270    
3 diseases for DLEU1:    
About MalaCards
b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia    leukemia


Find genes that share disorders with DLEU1           About GenesLikeMe

Genetic Association Database (GAD): DLEU1
Human Genome Epidemiology (HuGE) Navigator: DLEU1 (2 documents)

Export disorders for DLEU1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DLEU1 gene, integrated from 10 sources (see all 18):
(articles sorted by number of sources associating them with DLEU1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PubMed id 9395242)1, 2, 3, 9 Liu Y.... Oscier D. (Oncogene 1997)
  2. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PubMed id 11161783)1, 2, 9 Kapanadze B....Sangfelt O. (Genomics 2000)
  3. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (Croat. Med. J. 2009)
  4. B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. (PubMed id 11406609)1, 3 Wolf S....Lichter P. (Hum. Mol. Genet. 2001)
  5. Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. (PubMed id 23593011)1 Garding A....Mertens D. (PLoS Genet. 2013)
  6. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (Nature 2011)
  7. Chronic lymphocytic leukemia and 13q14: miRs and more. (PubMed id 19347735)1 Mertens D....Stilgenbauer S. (amp 2009)
  8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (Nature 2004)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10301 HGNC: 13747 AceView: DLEU1 Ensembl:ENSG00000176124 euGenes: HUgn10301
ECgene: DLEU1 H-InvDB: DLEU1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DLEU1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DLEU1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DLEU1 gene:
Search GeneIP for patents involving DLEU1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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