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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DLEU1 Gene

RNA gene GIFtS: 40
GCID: GC13P050656

deleted in lymphocytic leukemia 1 (non-protein coding)

(Previous names: deleted in lymphocytic leukemia, 1 )
(Previous symbols: DLB1, BCMS)

Explore 4 diseases affiliated with
DLEU1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 10

Aliases
Deleted In Lymphocytic Leukemia 1 (Non-Protein Coding)¹ ²		Deleted In Lymphocytic Leukemia, 1¹
LEU1¹ ² ³ ⁵		DLEU2²
XTP6¹ ² ³		LEU2²
BCMS¹ ²		Deleted In Lymphocytic Leukemia 1³
DLB1¹ ²		HBV X-Transactivated Gene 6 Protein³
LINC00021¹ ²		HBV XAg-Transactivated Protein 6³
NCRNA00021¹ ²

External Ids:	HGNC: 13747¹	Entrez Gene: 10301²	Ensembl: ENSG00000176124⁷	OMIM: 605765⁵	UniProtKB: O43261³

ORGUL members:	fRNAdb¹⁰:FR398061 FR373789 FR394898 FR023517 FR204240
	H-InvDB:HIT000247600 HIT000247585 HIT000247610
	NCBI:AJ412013 AJ412030 AJ411996 AJ412000 AJ412031	see all 38
	NONCODE:n334873 n373556 n373558 n386051 n386050	see all 25
	RNAdb:LIT1946 LIT1922 LIT1969 LIT1965 LIT1917	see all 40

Export aliases for DLEU1 gene to outside databases

Previous GC identifers: GC13P048656 GC13P044643 GC13P049592 GC13P048454 GC13P049554 GC13P031451

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LEU1_HUMAN, O43261

Function: May act as a tumor suppressor

Gene Wiki entry for DLEU1

fRNAdb sequence ontologies for DLEU1 - the ORGUL cluster for this gene includes several descriptions:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for DLEU1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DLEU1 gene promoter:
AML1a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for DLEU1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DLEU1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.3

DLEU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLEU1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P050656: view genomic region (about GC identifiers)

Start:	50,656,307 bp from pter	End:	51,298,199 bp from pter
Size:	641,893 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DLEU1

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LEU1_HUMAN, O43261 (See protein sequence)

Recommended Name: Leukemia-associated protein 1

Size: 78 amino acids; 8962 Da

Sequence caution: Sequence=CAA75515.1; Type=Frameshift; Positions=73;

Secondary accessions: Q547G6 Q8TE10 Q96QY5

Explore the universe of human proteins at neXtProt for DLEU1: NX_O43261

DLEU1 Protein expression data from MOPED and PaxDb: About this image

ENSEMBL proteins:

ENSP00000367422

Human Recombinant Protein Products for DLEU1:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: O43261

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LEU1_HUMAN, O43261

Function: May act as a tumor suppressor

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

DLEU1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DLEU1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLEU1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DLEU1

5/28 Interacting proteins for DLEU1 (O43261^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KAT5	Q92993¹^,²^,³	EBI-710057,EBI-399080 MINT-63124 I2D: score=3
ABCF3	Q9NUQ8²^,³	MINT-63125 I2D: score=3
CCDC90B	Q9GZT6²^,³	MINT-63127 I2D: score=3
COPS6	Q7L5N1²^,³	MINT-63121 I2D: score=3
EEF1G	P26641²^,³	MINT-63116 I2D: score=3

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DLEU1
Search CenterWatch for drugs/clinical trials and news about DLEU1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

5/22 fRNAdb Secondary structures (see all 22):

REFSEQ mRNAs for DLEU1 gene:

NM_005887.1

Unigene Clusters for DLEU1:

Deleted in lymphocytic leukemia 1 (non-protein coding)

Hs.591229 [show with all ESTs], Hs.712880 [show with all ESTs]

Unigene Representative Sequences: AK095311, AJ412031

18/35 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):

ENST00000491341(uc010ado.1) ENST00000468522(uc010adp.1) ENST00000491615(uc001veg.1 uc001vei.1)

ENST00000490577 ENST00000467721(uc010tgn.1) ENST00000463474(uc010adn.1)

ENST00000461527(uc001vee.1) ENST00000476738(uc010adm.1) ENST00000468168(uc001vef.1)

ENST00000378180(uc001vec.3) ENST00000469754(uc001ved.3) ENST00000478860

ENST00000486895(uc010adl.1) ENST00000484529(uc001vek.1) ENST00000485007(uc001vem.1)

ENST00000475913(uc001vel.1) ENST00000473075(uc001ven.1) ENST00000483444

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Additional cDNA sequence:

AJ412026.1 AJ412027.1 AJ412028.1 AJ412030.1 AJ412031.1 AJ412032.1 AJ412033.1 AJ412034.1

AJ412035.1 AJ412036.1 AJ412037.1 AJ412041.1 AJ412042.1 AJ412043.1 AJ412044.1 AJ412045.1

AJ412046.1 AJ412049.1 AJ412050.1 AJ412051.1 AJ412052.1 AJ412053.1 AJ412055.1 AJ412056.1

AJ412057.1 AJ412058.1 AJ412059.1 AJ412063.1

21 DOTS entries:

DT.92325323 DT.100888852 DT.455546 DT.120775026 DT.120774920 DT.95283746 DT.95283752 DT.120774773

DT.120774943 DT.75109265 DT.91714567 DT.95143444 DT.95283742 DT.95283743 DT.95283745 DT.95283748

DT.95283759 DT.40119497 DT.75146171 DT.95283744 DT.70104168

24/145 AceView cDNA sequences (see all 145):

AW089770 AJ412046 AA478587 CB156083 BU071717 AJ412056 AJ412040 BQ575432

AJ412042 BM725594 BE504299 AA418735 AL558390 AW136497 CR605740 AJ412051

BC020692 CR450325 AA479324 AJ412048 BU787701 AA425755 BU660035 AA258715

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for DLEU1:RNAdb

DLEU1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAGCCCA

About this image
See DLEU1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DLEU1

SOURCE GeneReport for Unigene clusters: Hs.591229 Hs.712880
SABiosciences Custom PCR Arrays for DLEU1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for DLEU1 (if available)
TreeFam Gene Tree for DLEU1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DLEU1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DLEU1 for disorders           About GeneDecksing

OMIM gene information: 605765OMIM information: 605766
4 diseases for DLEU1:    About MalaCards

lymphocytic leukemia leukemia sezary's disease chronic lymphocytic leukemia

Human Genome Epidemiology (HuGE) Navigator: DLEU1 (2 documents)

Export disorders for DLEU1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DLEU1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with DLEU1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PubMed id 9395242)^{1, 2, 3, 9} Liu Y.... Oscier D. (1997)
Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PubMed id 11161783)^{1, 2, 9} Kapanadze B....Sangfelt O. (2000)
B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. (PubMed id 11406609)^{1, 3} Wolf S....Lichter P. (2001)
Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)¹ ....Compston A. (2011)
Chronic lymphocytic leukemia and 13q14: miRs and more . (PubMed id 19347735)¹ Mertens D....Stilgenbauer S. (2009)
Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)¹ Polasek O....Rudan I. (2009)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)² Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10301	HGNC: 13747	AceView: DLEU1	Ensembl:ENSG00000176124	euGenes: HUgn10301
ECgene: DLEU1	H-InvDB: DLEU1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DLEU1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DLEU1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DLEU1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DLEU1 gene:
Search GeneIP for patents involving DLEU1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DLEU1

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DLEU1 gene at Home site.

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DLEU1 Gene

deleted in lymphocytic leukemia 1 (non-protein coding)

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DLEU1 Gene

deleted in lymphocytic leukemia 1 (non-protein coding)

Aliasesfor DLEU1 gene

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Proteinsfor DLEU1 gene

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for DLEU1 gene

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for DLEU1 gene

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for DLEU1 gene

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