Services
Jump to Section...
Aliases for DLEC1
Databases for DLEC1
Disorders for DLEC1
Domains/Families for DLEC1
Drugs/Compounds for DLEC1
Expression for DLEC1
Function for DLEC1
Location for DLEC1
Medical News for DLEC1
Orthologs for DLEC1
Paralogs for DLEC1
Pathways/Interactions for DLEC1
Proteins for DLEC1
Publications for DLEC1
SNPs for DLEC1
Search Box for DLEC1
Services for DLEC1
Summaries for DLEC1
Technologies for DLEC1
Transcripts for DLEC1
TOP
BOTTOM
Aliases & Descriptions for DLEC1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Aliases DLC-1 3 DLC1 1 , 2 , 3 , 5 F56 2
Descriptions Deleted in lung cancer protein 1 3 deleted in lung and esophageal cancer 1 2 deleted in lung cancer 1 2
Search outside databases for aliases for DLEC1 genePrevious GC identifers: GC03M038095 GC03P037352 GC03P037893 GC03P038041
Summaries for DLEC1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
EntrezGene summary for DLEC1 : This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3chromosomal segment that is commonly deleted in various carcinomas. Several alternatively splicedtranscripts have been observed that contain disrupted coding regions and likely encodenonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis ofthe lung, esophagus, and kidney. [provided by RefSeq] UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238 Function : May act as a tumor suppressor by inhibiting cell proliferation
Genomic Location for DLEC1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DLEC1 gene Entrez Gene cytogenetic band: 3p22-p21.3 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p21.3 DLEC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P038055:
(about GC identifiers )
Start:
38,055,700 bp from pter
End:
38,139,233 bp from pter
Size:
83,534 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000003.10 NT_022517.17 Proteins for DLEC1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238 (See
protein sequence )Recommended Name: Deleted in lung and esophageal cancer protein 1 Size : 1755 amino acids; 195783 Da
Subcellular location : Cytoplasm
Sequence caution : Sequence=CAB70676.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions : Q9NSW0 Q9NTG5Alternative splicing : 3 isoforms : Q9Y238-1 Q9Y238-2 Q9Y238-3 (At least six differentially spliced products may exist)
REFSEQ proteins (2 alternative transcripts):
NP_031361.2 NP_031363.2 ENSEMBL proteins: ENSP00000308597 ENSP00000315914 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for DLEC1: Assays for DLEC1:
Protein
Domains/ Families for DLEC1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
ProtoNet protein and cluster: Q9Y238
Gene Function for DLEC1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_007335 Applied Biosystems Silencer ® siRNAs for DLEC1 Sigma-Aldrich siRNA for DLEC1 Sigma-Aldrich shRNA Panels and shRNA for DLEC1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_007335                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_007335                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_007335  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007337 UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238 Function : May act as a tumor suppressor by inhibiting cell proliferation
Genatlas biochemistry entry for DLEC1 :gene deleted in lung cancer 1,esophaegus and kidney cancer cell lines,see TSG3C 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
About this table
Pathways & Interactions for DLEC1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008285 negative regulation of cell proliferation
TAS 10213508 GO:0045786 negative regulation of cell cycle
IEA --
About this table
Drugs & Compounds for DLEC1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Browse Tocris compounds for DLEC1
Transcripts for DLEC1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_007335 Sigma-Aldrich siRNA for DLEC1 Sigma-Aldrich shRNA Panels and shRNA for DLEC1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_007335 NM_007337
REFSEQ mRNAs for DLEC1 gene (2 alternative transcripts): NM_007335.2 NM_007337.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007335 NM_007337
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_007335                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_007335                                  untagged cDNA clones in CMV expression vector (see all 5 ): NM_007335  
Additional cDNA sequence: AB020522.1 AB425198.1 AK302803.1 AL137282.1 AL137706.1 AY789462.1 AY789463.1 AY789464.1 BC127645.1 BC129824.1 BC129825.1 BC171799.1
14 DOTS entries : DT.455613 DT.75133679 DT.100669833 DT.92450061 DT.95212056 DT.100022012 DT.120879253 DT.120879229 DT.100022011 DT.100879782 DT.120879248 DT.95254365 DT.120879231 DT.120879302
24/42 AceView cDNA sequences (see all 42
):NM_005106 NM_007335 NM_007336 CB243860 AI910883 BI035862 AL137706 NM_007337 AL137282 CA313934 AB020522 CA312917 CA314930 NM_007338 BV183448 AL039638 BV198780 AI955519 BV183447 BU686360 BM996393 BU680752 AA905764 AW002814
highest scoring ESTs for DLEC1 :AB020522 AA905764 BU680752 BU782583 BU783570 CA313934 CB243647 AA995144 AI803828 AI874185
Unigene Cluster for DLEC1: Deleted in lung and esophageal cancer 1 Hs.714499 [show with all ESTs ] Unigene Representative Sequence: NM_007335 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000308059
ENST00000346219
Expression for DLEC1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
DLEC1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DLEC1 1 / 2 / 3
7 probe-sets matching DLEC1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CACTTTTACTSOURCE GeneReport for Unigene cluster: Hs.714499 Expression variation in blood from EXPOLDB for DLEC1
UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238 Tissue specificity : Expressed in all tissues examined. Expression is highest in prostate and testis
Orthologs for DLEC1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Orthologs for DLEC1 gene from 3 species
About this table Species with no ortholog for DLEC1 ENSEMBL Gene Tree for DLEC1 Paralogs for DLEC1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
SNPs/Variants for DLEC1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
HapMap Linkage Disequilibrium images for DLEC1 (up to first 250kb)
Disorders & Mutations for DLEC1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
OMIM: 604050 disorders : 211980 133239 UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238
Defects in DLEC1 may be a cause of primary lung cancer [MIM:211980]. In 33% of lung,esophageal and renal cancer cell lines and primary cancers, there is a lack of functionaltranscripts and an increase in alternatively spliced non-functional transcripts; the gene itselfis not altered Defects in DLEC1 may be a cause of esophageal cancer [MIM:133239] Defects in DLEC1 may be a cause of renal cancer Defects in DLEC1 may be a cause of breast cancer
5 Novoseek disease relationships for DLEC1 gene
About this table Human Genome Epidemiology Navigator: DLEC1 (1 document)
Medical News for DLEC1 (Possibly Related Articles in
Doctor's Guide )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Publications for DLEC1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
10/20 PubMed articles for DLEC1 gene (see all 20
):
Search for DLEC1
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genome Databases showing DLEC1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Other Databases showing DLEC1
(According to HUGE )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Specialized Databases showing DLEC1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
-- Services for DLEC1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Products for DLEC1:
Search Tocris compounds for DLEC1
Jump to Section...
Aliases for DLEC1
Databases for DLEC1
Disorders for DLEC1
Domains/Families for DLEC1
Drugs/Compounds for DLEC1
Expression for DLEC1
Function for DLEC1
Location for DLEC1
Medical News for DLEC1
Orthologs for DLEC1
Paralogs for DLEC1
Pathways/Interactions for DLEC1
Proteins for DLEC1
Publications for DLEC1
SNPs for DLEC1
Search Box for DLEC1
Services for DLEC1
Summaries for DLEC1
Technologies for DLEC1
Transcripts for DLEC1
TOP
BOTTOM
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009