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Aliases for DLEC1 Gene

Aliases for DLEC1 Gene

  • Deleted In Lung And Esophageal Cancer 1 2 3 5
  • Cilia And Flagella Associated Protein 81 2 3
  • DLC-1 3 4
  • DLC1 3 4
  • Deleted In Lung Cancer Protein 1 4
  • CFAP81 3
  • F56 3

External Ids for DLEC1 Gene

Previous GeneCards Identifiers for DLEC1 Gene

  • GC03M038095
  • GC03P037352
  • GC03P037893
  • GC03P038041
  • GC03P038055
  • GC03P038023

Summaries for DLEC1 Gene

Entrez Gene Summary for DLEC1 Gene

  • The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]

GeneCards Summary for DLEC1 Gene

DLEC1 (Deleted In Lung And Esophageal Cancer 1) is a Protein Coding gene. Diseases associated with DLEC1 include esophageal cancer and lung cancer.

UniProtKB/Swiss-Prot for DLEC1 Gene

  • May act as a tumor suppressor by inhibiting cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLEC1 Gene

Genomics for DLEC1 Gene

Regulatory Elements for DLEC1 Gene

Enhancers for DLEC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DLEC1 on UCSC Golden Path with GeneCards custom track

Promoters for DLEC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DLEC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLEC1 Gene

Chromosome:
3
Start:
38,038,605 bp from pter
End:
38,124,025 bp from pter
Size:
85,421 bases
Orientation:
Plus strand

Genomic View for DLEC1 Gene

Genes around DLEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEC1 Gene

Proteins for DLEC1 Gene

  • Protein details for DLEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y238-DLEC1_HUMAN
    Recommended name:
    Deleted in lung and esophageal cancer protein 1
    Protein Accession:
    Q9Y238
    Secondary Accessions:
    • Q9NSW0
    • Q9NTG5

    Protein attributes for DLEC1 Gene

    Size:
    1755 amino acids
    Molecular mass:
    195684 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70676.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB70884.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DLEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLEC1 Gene

Proteomics data for DLEC1 Gene at MOPED

Post-translational modifications for DLEC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLEC1 Gene

No data available for DME Specific Peptides for DLEC1 Gene

Domains & Families for DLEC1 Gene

Protein Domains for DLEC1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLEC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DLEC1 Gene

Function for DLEC1 Gene

Molecular function for DLEC1 Gene

GENATLAS Biochemistry:
gene deleted in lung cancer 1,esophaegus and kidney cancer cell lines,see TSG3C
UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor by inhibiting cell proliferation.
genes like me logo Genes that share phenotypes with DLEC1: view

Human Phenotype Ontology for DLEC1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DLEC1 Gene

MGI Knock Outs for DLEC1:

Animal Model Products

miRNA for DLEC1 Gene

miRTarBase miRNAs that target DLEC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DLEC1 Gene

Localization for DLEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLEC1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLEC1 Gene COMPARTMENTS Subcellular localization image for DLEC1 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DLEC1 Gene

Pathways & Interactions for DLEC1 Gene

SuperPathways for DLEC1 Gene

No Data Available

Interacting Proteins for DLEC1 Gene

Gene Ontology (GO) - Biological Process for DLEC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DLEC1 Gene

Drugs & Compounds for DLEC1 Gene

(1) Additional Compounds for DLEC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLEC1: view

Transcripts for DLEC1 Gene

Unigene Clusters for DLEC1 Gene

Deleted in lung and esophageal cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLEC1 Gene

No ASD Table

Relevant External Links for DLEC1 Gene

GeneLoc Exon Structure for
DLEC1
ECgene alternative splicing isoforms for
DLEC1

Expression for DLEC1 Gene

mRNA expression in normal human tissues for DLEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLEC1 Gene

This gene is overexpressed in Testis (x9.1), Pituitary (x8.8), Fallopian Tube (x7.9), and Cervix - Endocervix (x4.6).

Protein differential expression in normal tissues from HIPED for DLEC1 Gene

This gene is overexpressed in Spleen (62.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLEC1 Gene



SOURCE GeneReport for Unigene cluster for DLEC1 Gene Hs.714499

mRNA Expression by UniProt/SwissProt for DLEC1 Gene

Q9Y238-DLEC1_HUMAN
Tissue specificity: Expressed in all tissues examined. Expression is highest in prostate and testis.
genes like me logo Genes that share expression patterns with DLEC1: view

Protein tissue co-expression partners for DLEC1 Gene

Primer Products

In Situ Assay Products

Orthologs for DLEC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DLEC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLEC1 35
  • 83.19 (n)
  • 78.29 (a)
DLEC1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLEC1 35
  • 83.87 (n)
  • 78.92 (a)
DLEC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlec1 35
  • 77.72 (n)
  • 72.85 (a)
Dlec1 16
Dlec1 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLEC1 35
  • 98.54 (n)
  • 98.22 (a)
DLEC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlec1 35
  • 77.59 (n)
  • 72.09 (a)
oppossum
(Monodelphis domestica)
Mammalia DLEC1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves DLEC1 35
  • 58.31 (n)
  • 49.02 (a)
DLEC1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLEC1 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlec1 35
  • 55.68 (n)
  • 46.19 (a)
zebrafish
(Danio rerio)
Actinopterygii dlec1 35
  • 51.21 (n)
  • 41.85 (a)
dlec1 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for DLEC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLEC1 Gene

ENSEMBL:
Gene Tree for DLEC1 (if available)
TreeFam:
Gene Tree for DLEC1 (if available)

Paralogs for DLEC1 Gene

Pseudogenes.org Pseudogenes for DLEC1 Gene

genes like me logo Genes that share paralogs with DLEC1: view

No data available for Paralogs for DLEC1 Gene

Variants for DLEC1 Gene

Sequence variations from dbSNP and Humsavar for DLEC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035908 A breast cancer sample
rs7625806 - 38,039,461(+) TCAGC(G/T)GCTTC nc-transcript-variant, reference, missense
rs34012183 - 38,059,754(+) TGTCT(C/T)CAGAT nc-transcript-variant, reference, missense
VAR_056862 -
VAR_056863 -

Structural Variations from Database of Genomic Variants (DGV) for DLEC1 Gene

Variant ID Type Subtype PubMed ID
dgv1447e1 CNV Complex 17122850
dgv1448e1 CNV Complex 17122850
nsv428416 CNV Loss 18775914
nsv508911 CNV Insertion 20534489
nsv819131 CNV Loss 19587683
nsv820288 CNV Insertion 19587683
esv2665102 CNV Deletion 23128226
esv2669825 CNV Deletion 23128226
nsv237307 CNV Loss 16902084
esv1008921 CNV Deletion 20482838
esv1683994 CNV Deletion 17803354
esv2725160 CNV Deletion 23290073

Variation tolerance for DLEC1 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.64; 91.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLEC1 Gene

HapMap Linkage Disequilibrium report
DLEC1
Human Gene Mutation Database (HGMD)
DLEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEC1 Gene

Disorders for DLEC1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DLEC1 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
lung cancer
  • lung cancer, protection against
inverted papilloma
  • inverted papilloma, squamous cell
- elite association - COSMIC cancer census association via MalaCards
Search DLEC1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DLEC1_HUMAN
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:10213508}. Note=The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription may be implicated in the development of esophageal cancer.
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer.
  • Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR).

Relevant External Links for DLEC1

Genetic Association Database (GAD)
DLEC1
Human Genome Epidemiology (HuGE) Navigator
DLEC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLEC1
genes like me logo Genes that share disorders with DLEC1: view

No data available for Genatlas for DLEC1 Gene

Publications for DLEC1 Gene

  1. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. (PMID: 10213508) Daigo Y. … Nakamura Y. (Cancer Res. 1999) 2 3 4 67
  2. DLEC1, a 3p tumor suppressor, represses NF-I_B signaling and is methylated in prostate cancer. (PMID: 25648635) Zhang L. … Jin J. (J. Mol. Med. 2015) 3
  3. DLEC1 is not silenced solely by promoter methylation in head and neck squamous cell carcinoma. (PMID: 25746324) Seven D. … Buyru N. (Gene 2015) 3
  4. Methylation of DLEC1 promoter is a predictor for recurrence in Chinese patients with gastric cancer. (PMID: 25574068) Ye X. … Sun G. (Dis. Markers 2014) 3
  5. Downregulation of DLEC1 in sinonasal inverted papilloma and squamous cell carcinoma. (PMID: 22569009) Chang P.H. … Tsai C.N. (J Otolaryngol Head Neck Surg 2012) 3

Products for DLEC1 Gene

Sources for DLEC1 Gene

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