V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

DLEC1 Gene

protein-coding   GIFtS: 49

GC03P038055
deleted in lung and esophageal cancer 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DLC-1 3
DLC1 1, 2, 3, 5
F56 2
Descriptions
Deleted in lung cancer protein 1 3
deleted in lung and esophageal cancer 1 2
deleted in lung cancer 1 2
External Ids
HGNC: 28991
Entrez Gene: 99402
UniProtKB: Q9Y2383
Ensembl: ENSG000000082267
Search outside databases for aliases for DLEC1 gene

Previous GC identifers: GC03M038095 GC03P037352 GC03P037893 GC03P038041

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DLEC1:
This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3
chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced
transcripts have been observed that contain disrupted coding regions and likely encode
nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of
the lung, esophagus, and kidney. [provided by RefSeq]

UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238
Function: May act as a tumor suppressor by inhibiting cell proliferation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DLEC1 gene  

Entrez Gene cytogenetic band: 3p22-p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.3

DLEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038055:     (about GC identifiers)

Start:
38,055,700 bp from pter
End:
38,139,233 bp from pter
Size:
83,534 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238 (See protein sequence)
Recommended Name: Deleted in lung and esophageal cancer protein 1  
Size: 1755 amino acids; 195783 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=CAB70676.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q9NSW0 Q9NTG5
Alternative splicing: 3 isoforms:  Q9Y238-1   Q9Y238-2   Q9Y238-3   (At least six differentially spliced products may exist)

REFSEQ proteins (2 alternative transcripts): 
NP_031361.2  NP_031363.2  


ENSEMBL proteins: 
ENSP00000308597 ENSP00000315914 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (DLC-1)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IDA10213508
About this table

Antibodies for DLEC1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for DLEC1
Browse R&D Systems for Antibodies
Antibodies from Abcam (DLC-1), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for DLEC1

Assays for DLEC1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9Y238

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DLEC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_007335

              Applied Biosystems Silencer® siRNAs for DLEC1

              Sigma-Aldrich siRNA for DLEC1  
                     Sigma-Aldrich shRNA Panels and shRNA for DLEC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_007335
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_007335
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_007335 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_007337

UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238
Function: May act as a tumor suppressor by inhibiting cell proliferation

Genatlas biochemistry entry for DLEC1:
gene deleted in lung cancer 1,esophaegus and kidney cancer cell lines,see TSG3C

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003674 molecular_function ND--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008285 negative regulation of cell proliferation TAS10213508
GO:0045786 negative regulation of cell cycle IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DLEC1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DLEC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_007335

              Sigma-Aldrich siRNA for DLEC1  
                     Sigma-Aldrich shRNA Panels and shRNA for DLEC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_007335  NM_007337  

REFSEQ mRNAs for DLEC1 gene (2 alternative transcripts): 

NM_007335.2   NM_007337.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_007335  NM_007337  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_007335
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_007335
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_007335 

Additional cDNA sequence: 

AB020522.1 AB425198.1 AK302803.1 AL137282.1 AL137706.1 AY789462.1 AY789463.1 AY789464.1 
BC127645.1 BC129824.1 BC129825.1 BC171799.1 

14 DOTS entries:

DT.455613  DT.75133679  DT.100669833  DT.92450061  DT.95212056  DT.100022012  DT.120879253  DT.120879229 
DT.100022011  DT.100879782  DT.120879248  DT.95254365  DT.120879231  DT.120879302 

24/42 AceView cDNA sequences (see all 42 ):

NM_005106 NM_007335 NM_007336 CB243860 AI910883 BI035862 AL137706 NM_007337 
AL137282 CA313934 AB020522 CA312917 CA314930 NM_007338 BV183448 AL039638 
BV198780 AI955519 BV183447 BU686360 BM996393 BU680752 AA905764 AW002814 

highest scoring ESTs for DLEC1:

AB020522 AA905764 BU680752 BU782583 BU783570 CA313934 CB243647 AA995144 AI803828 AI874185 

Unigene Cluster for DLEC1:

Deleted in lung and esophageal cancer 1
Hs.714499  [show with all ESTs]
Unigene Representative Sequence: NM_007335


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000308059  ENST00000346219  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DLEC1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for DLEC1

1 / 2 / 3

7 probe-sets matching DLEC1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
35918_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB020522 1.00 1.00 1.00 1

215085_x_at2, 3 U133-A 1 1.00 1.00 -- -- AL137706 0.40 1.00 0.76 1

207896_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_007337 0.60 1.00 0.82 1

206798_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005106 0.40 1.00 0.76 1

215085_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

207896_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

206798_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  DLEC1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CACTTTTACT

SOURCE GeneReport for Unigene cluster: Hs.714499

Expression variation in blood from EXPOLDB for DLEC1

UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238
Tissue specificity: Expressed in all tissues examined. Expression is highest in prostate and testis

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for DLEC1 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
cow
(Bos taurus)
DLEC11   -- deleted in lung and esophageal cancer 1 83.27(n)
78.4(a)
618746  XM_871071.2  XP_876164.2 
mouse
(Mus musculus)
Dlec11, 5 95
deleted in lung and esophageal cancer 11, 5 77.55(n)1
72.48(a)1
3202561  XM_486268.31  XP_486268.21 
 AA4735625  AK0458485  (see all 9)
zebrafish
(Danio rerio)
LOC5555831   -- similar to deleted in lung and esophageal cancer 1 51.33(n)
42.16(a)
555583  XM_678134.2  XP_683226.2 
About this table        Species with no ortholog for DLEC1

ENSEMBL Gene Tree for DLEC1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/548 NCBI SNPs in DLEC1 are shown (see all 548 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 148)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs98401721,2
A,C,F,H38128176(+) GTCCCA/GACATG 2 N/D mis18Minor allele frequency- G:0.01EU EA WA 840
rs98100851,2
C,F,H38130850(+) CCTGCT/CGCCGG 2 P/L mis1 ese38Minor allele frequency- C:0.01EU EA WA 832
rs2022101,2
C,H38133721(+) TTCCAG/CGGAAG 2 R/G mis1 ese3 trp38Minor allele frequency- C:0.00EA NA MN EU WA 656
--
rs4184951,2
C,H38078793(+) GTTAGA/CCCACA 2 D/A mis1 ese35Minor allele frequency- C:0.00MN EU EA WA 600
rs340121831,2
C,F38076249(+) TGTCTC/TCAGAT 2 S/F mis15Minor allele frequency- T:0.02NA EU EA WA 494
rs20737131,2
C,H38131524(+) CCCTTC/TGCCTG 2 R/C mis1 ese34Minor allele frequency- T:0.00EU EA WA 418
rs360129221,2
C,F38124947(+) CCCAAA/TCATGG 2 K/N mis15Minor allele frequency- T:0.03NA EU EA WA 498
rs4518631,2
H38076326(+) CAGTGC/GCGTTT 2 P/A mis1 ese35Minor allele frequency- G:0.00MN EU EA WA 584
rs25179631,2
H38101780(+) TCCCAG/CGAAAA 2 R/G mis1 ese34Minor allele frequency- C:0.00EU EA WA 400
rs4191641,2
C38079087(+) AGTCAA/TCCAAG 2 Q/H mis15Minor allele frequency- T:0.05MN EU EA WA 600
About this table

HapMap Linkage Disequilibrium images for DLEC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604050   disorders: 211980  133239  

UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238

  • Defects in DLEC1 may be a cause of primary lung cancer [MIM:211980]. In 33% of lung,
    esophageal and renal cancer cell lines and primary cancers, there is a lack of functional
    transcripts and an increase in alternatively spliced non-functional transcripts; the gene itself
    is not altered
  • Defects in DLEC1 may be a cause of esophageal cancer [MIM:133239]
  • Defects in DLEC1 may be a cause of renal cancer
  • Defects in DLEC1 may be a cause of breast cancer
  • 5 Novoseek disease relationships for DLEC1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 46.53 22 16533763 (6)
    breast carcinoma 36.09 2 12645648 (1)
    tumors 25.85 25 17932950 (4), 17521951 (3), 15674352 (2), 12645648 (2) (see all 8)
    prostate cancer 19.88 4 16533763 (1), 12645648 (1)
    cancer 0.34 11 17521951 (3), 12645648 (1), 17418982 (1)
    About this table

    Human Genome Epidemiology Navigator: DLEC1 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/20 PubMed articles for DLEC1 gene (see all 20 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9940 HGNC: 2899 AceView: DLEC1 Ensembl:ENSG00000008226 euGenes: HUgn9940
    ECgene: DLEC1 H-InvDB: DLEC1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for DLEC1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for DLEC1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DLEC1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for DLEC1 Antibodies for DLEC1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for DLEC1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (DLC-1)
     Antibodies (DLC-1)
     Search OriGene for DLEC1
     Search Tocris compounds for DLEC1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for DLEC1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    DLEC1 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com