Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DLEC1 Gene

protein-coding   GIFtS: 45
GCID: GC03P038080

Deleted In Lung And Esophageal Cancer 1

  See DLEC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Deleted In Lung And Esophageal Cancer 11 2     Deleted In Lung And Esophageal Cancer 1 Transcript Varient 22
DLC12 3 5     Deleted In Lung And Esophageal Cancer Protein 12
DLC-12 3     Deleted In Lung Cancer Protein 13
F562     

External Ids:    HGNC: 28991   Entrez Gene: 99402   Ensembl: ENSG000000082267   OMIM: 6040505   UniProtKB: Q9Y2383   

Export aliases for DLEC1 gene to outside databases

Previous GC identifers: GC03M038095 GC03P037352 GC03P037893 GC03P038041 GC03P038055 GC03P038023


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DLEC1 Gene:
This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that
is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that
contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene
may be involved in carcinogenesis of the lung, esophagus, and kidney. (provided by RefSeq, Jul 2008)

GeneCards Summary for DLEC1 Gene:
DLEC1 (deleted in lung and esophageal cancer 1) is a protein-coding gene. Diseases associated with DLEC1 include esophageal cancer, and brown-vialetto-van laere syndrome.

UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238
Function: May act as a tumor suppressor by inhibiting cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the DLEC1 gene promoter:
         RP58   AML1a   Pax-5   GATA-3   p53   RelA   NF-kappaB   AP-2gamma   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDLEC1 promoter sequence
   Search Chromatin IP Primers for DLEC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.3

DLEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DLEC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038080:  view genomic region     (about GC identifiers)

Start:
38,080,696 bp from pter      End:
38,165,516 bp from pter
Size:
84,821 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238 (See protein sequence)
Recommended Name: Deleted in lung and esophageal cancer protein 1  
Size: 1755 amino acids; 195684 Da
Sequence caution: Sequence=CAB70676.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAB70884.2;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q9NSW0 Q9NTG5
Alternative splicing: 3 isoforms:  Q9Y238-1   Q9Y238-2   Q9Y238-3   (Levels of this splice isoform are increased in cancer cell lines and primary cancers)

Explore the universe of human proteins at neXtProt for DLEC1: NX_Q9Y238

Explore proteomics data for DLEC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DLEC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_031361.2  NP_031363.2  

    ENSEMBL proteins: 
     ENSP00000308597   ENSP00000404261   ENSP00000315914   ENSP00000410427  

    DLEC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DLEC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DLEC1
    GenScript Custom Purified and Recombinant Proteins Services for DLEC1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DLEC1

     
    Search eBioscience for Proteins for DLEC1 

    DLEC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DLEC1
    OriGene Custom Antibody Services for DLEC1
    Abcam antibodies for DLEC1
    Cloud-Clone Corp. Antibodies for DLEC1
    Search ThermoFisher Antibodies for DLEC1
    LSBio Antibodies in human, mouse, rat for DLEC1

    DLEC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DLEC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DLEC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DLEC1
    Cloud-Clone Corp. CLIAs for DLEC1
    Search eBioscience for ELISAs for DLEC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus

    ProtoNet protein and cluster: Q9Y238


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLEC1_HUMAN, Q9Y238
    Function: May act as a tumor suppressor by inhibiting cell proliferation

         Genatlas biochemistry entry for DLEC1:
    gene deleted in lung cancer 1,esophaegus and kidney cancer cell lines,see TSG3C

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with DLEC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DLEC1:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Dlec1 (no phenotypes)

    Find genes that share phenotypes with DLEC1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLEC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLEC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DLEC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DLEC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DLEC1:
    hsa-mir-20a-5p (MIRT050541), hsa-let-7d-5p (MIRT032148), hsa-mir-186-5p (MIRT021186), hsa-mir-30c-5p (MIRT048014), hsa-mir-16-5p (MIRT031720), hsa-mir-877-3p (MIRT036947), hsa-let-7b-5p (MIRT005042)

    Block miRNA regulation of human, mouse, rat DLEC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DLEC1
    SwitchGear 3'UTR luciferase reporter plasmidDLEC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DLEC1
    Predesigned siRNA for gene silencing in human, mouse, rat DLEC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DLEC1

    Clone
    Products:
         
    OriGene clones in human, mouse for DLEC1 (see all 7)
    OriGene ORF clones in mouse, rat for DLEC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DLEC1 (NM_007335)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLEC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLEC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DLEC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DLEC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLEC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DLEC1_HUMAN, Q9Y238: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with DLEC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DLEC1
    Interactions:

        Search GeneGlobe Interaction Network for DLEC1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation TAS10213508

    Find genes that share ontologies with DLEC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DLEC1

    1 Novoseek inferred chemical compound relationship for DLEC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 60.5 1 16489177 (1)



    Find genes that share compounds with DLEC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DLEC1 gene (4 alternative transcripts): 
    NM_007335.2  NM_007337.2  NM_007336.1  NM_007338.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440294(uc010hgw.1 uc003chq.1) ENST00000308059(uc003cho.1)
    ENST00000447130 ENST00000469151 ENST00000477260 ENST00000478428(uc003chs.1)
    ENST00000346219(uc003chp.1) ENST00000452631(uc010hgv.1 uc003chr.1 uc010hgx.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DLEC1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DLEC1
    SwitchGear 3'UTR luciferase reporter plasmidDLEC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DLEC1
    Predesigned siRNA for gene silencing in human, mouse, rat DLEC1
    Clone
    Products:
         
    OriGene clones in human, mouse for DLEC1 (see all 7)
    OriGene ORF clones in mouse, rat for DLEC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DLEC1 (NM_007335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DLEC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLEC1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DLEC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLEC1
      QuantiTect SYBR Green Assays in human, mouse, rat DLEC1
      QuantiFast Probe-based Assays in human, mouse, rat DLEC1

    Selected AceView cDNA sequences (see all 42):

    BI035862 NM_007335 NM_007337 NM_007336 CB243860 CA313934 AI910883 AL137282 
    NM_005106 AL137706 AB020522 AL039638 CA312917 BV183447 BV183448 BU680752 
    BU686360 AI955519 CA314930 BM996393 NM_007338 BV198780 BU783570 CB243647 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DLEC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTTTACT
    DLEC1 Expression
    About this image


    DLEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    DLEC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DLEC1 Protein Expression

    UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238
    Tissue specificity: Expressed in all tissues examined. Expression is highest in prostate and testis

        Custom PCR Arrays for DLEC1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DLEC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLEC1
    QuantiTect SYBR Green Assays in human, mouse, rat DLEC1
    QuantiFast Probe-based Assays in human, mouse, rat DLEC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLEC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DLEC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dlec11 , 5 deleted in lung and esophageal cancer 11, 5 77.72(n)1
    72.85(a)1
      9 (71.32 cM)5
    3202561  NM_177117.31  NP_796091.21 
     1191024785 
    chicken
    (Gallus gallus)
    Aves DLEC11 deleted in lung and esophageal cancer 1 58.31(n)
    49.02(a)
      420418  XM_003640674.2  XP_003640722.2 
    lizard
    (Anolis carolinensis)
    Reptilia DLEC16
    deleted in lung and esophageal cancer 1
    46(a)
    1 ↔ 1
    6(1026174-1063396)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dlec11 deleted in lung and esophageal cancer 1 55.68(n)
    46.19(a)
      100488518  XM_002938006.2  XP_002938052.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dlec11 deleted in lung and esophageal cancer 1 51.21(n)
    41.85(a)
      555583  XM_678134.4  XP_683226.4 


    ENSEMBL Gene Tree for DLEC1 (if available)
    TreeFam Gene Tree for DLEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DLEC1 gene

    Find genes that share paralogs with DLEC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DLEC1
    PGOHUM00000237590


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DLEC1 (see all 2285)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359084
    A breast cancer sample4--see VAR_0359082 P R mis40--------
    rs1491907171,2
    Cuntested138033468(+) ACACCG/AATACA 4 /N /D mis11Minor allele frequency- A:0.00EU 1323
    rs1895877021,2
    --38010913(+) CAAGCA/GGAACT 2 -- us2k10--------
    rs758198621,2
    F--38011103(+) CTCCTC/TCCCCC 2 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1499743691,2
    --38011106(+) CTCCCC/GCCACC 2 -- us2k10--------
    rs1456464881,2
    C--38011218(+) TCCCAC/TGTGCC 2 -- us2k10--------
    rs1489099881,2
    --38011331(+) CAGGGC/TAGGCG 2 -- us2k10--------
    rs1464988681,2
    --38011562(+) AAATGA/TCAACA 2 -- us2k10--------
    rs1166431811,2
    C,F--38011905(+) ATGCCC/TCAGCT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs127153031,2
    C,F--38011936(+) ctactG/Tccctc 2 -- us2k12Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for DLEC1 (38080696 - 38165516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DLEC1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1683994CNV Deletion17803354
    esv2725160CNV Deletion23290073
    esv1008921CNV Deletion20482838
    esv2665102CNV Deletion23128226
    esv2669825CNV Deletion23128226
    nsv508911CNV Insertion20534489
    nsv820288CNV Insertion19587683
    nsv428416CNV Loss18775914
    nsv237307CNV Loss16902084
    nsv819131CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DLEC1
    DNA2.0 Custom Variant and Variant Library Synthesis for DLEC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604050   
    OMIM disorders: 211980  133239  
    UniProtKB/Swiss-Prot: DLEC1_HUMAN, Q9Y238
  • Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the
    development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR)
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The disease is caused by mutations affecting the gene represented in this
    entry. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development
    of lung cancer
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are
    esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease
    because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease is
    caused by mutations affecting the gene represented in this entry. DLEC1 silencing due to promoter methylation and
    aberrant transcription are implicated in the development of esophageal cancer

  • 3 diseases for DLEC1:    
    About MalaCards
    esophageal cancer    brown-vialetto-van laere syndrome    lung cancer


    Find genes that share disorders with DLEC1           About GenesLikeMe

    5 Novoseek inferred disease relationships for DLEC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate carcinoma 44.7 22 16533763 (6)
    breast carcinoma 34 2 12645648 (1)
    tumors 26.9 27 17932950 (4), 17521951 (3), 15674352 (2), 12645648 (2) (see all 9)
    prostate cancer 16.9 4 16533763 (1), 12645648 (1)
    cancer 6.93 12 17521951 (3), 12645648 (1), 19667410 (1), 17418982 (1)

    Genetic Association Database (GAD): DLEC1
    Human Genome Epidemiology (HuGE) Navigator: DLEC1 (2 documents)

    Export disorders for DLEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DLEC1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with DLEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. (PubMed id 10213508)1, 2, 3 Daigo Y....Nakamura Y. (Cancer Res. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    4. Downregulation of DLEC1 in sinonasal inverted papilloma and squamous cell carcinoma. (PubMed id 22569009)1 Chang P.H....Tsai C.N. (amp 2012)
    5. Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas. (PubMed id 23050586)1 Wang Z....Tao Q. (J Transl Med 2012)
    6. Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, is associated with more advanced tumor stage. (PubMed id 20639048)1 Zhang Q....Jin J. (J. Urol. 2010)
    7. Transcriptional repression of DLEC1 associates with the depth of tumor invasion in oral squamous cell carcinoma. (PubMed id 20952247)1 Chan W.H....Tsai C.N. (Oral Oncol. 2010)
    8. Epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in gastric and colorectal adenocarcinoma. (PubMed id 21443130)1 Zhang Y....Chen L. (Hepatogastroenterology 2010)
    9. Evidence of a tumour suppressor function for DLEC1 in human breast cancer. (PubMed id 20530412)1 Al Sarakbi W....Mokbel K. (Anticancer Res. 2010)
    10. Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer. (PubMed id 20630829)1 Zhang Y....Chen L. (Clin Lung Cancer 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9940 HGNC: 2899 AceView: DLEC1 Ensembl:ENSG00000008226 euGenes: HUgn9940
    ECgene: DLEC1 H-InvDB: DLEC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DLEC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DLEC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DLEC1 gene:
    Search GeneIP for patents involving DLEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DLEC1   OriGene RNAi products in human, mouse, rat for DLEC1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DLEC1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DLEC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DLEC1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DLEC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DLEC1   OriGene Custom Protein Services for DLEC1  

     
     
     Block miRNA regulation of human, mouse, rat DLEC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DLEC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DLEC1 Predesigned siRNA for gene silencing in human, mouse, rat DLEC1
     QuantiFast Probe-based Assays in human, mouse, rat DLEC1 QuantiTect SYBR Green Assays in human, mouse, rat DLEC1
     Custom PCR Arrays for DLEC1 Search Chromatin IP Primers for DLEC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DLEC1  Search GeneGlobe Interaction Network for DLEC1
     Regulatory tfbs in DLEC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DLEC1 GenScript cDNA clones with any tag delivered in your preferred vector for DLEC1
     GenScript Custom Assay Services for DLEC1 GenScript Custom overexpressing Cell Line Services for DLEC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DLEC1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for DLEC1
     See all of Abcam's Antibodies, Kits and Proteins for DLEC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DLEC1
     Antibodies for DLEC1
     ELISAs for DLEC1
     CLIAs for DLEC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DLEC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DLEC1
     SwitchGear 3'UTR luciferase reporter plasmids for DLEC1
     SwitchGear Promoter luciferase reporter plasmids for DLEC1
     Search ThermoFisher Antibodies for DLEC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DLEC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DLEC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DLEC1
     LSBio Antibodies in human, mouse, rat for DLEC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DLEC1
      Search eBioscience for proteins for DLEC1
      Search eBioscience for elisas for DLEC1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DLEC1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4