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Aliases for DLEC1 Gene

Aliases for DLEC1 Gene

  • Deleted In Lung And Esophageal Cancer 1 2 3 5
  • Cilia And Flagella Associated Protein 81 2 3
  • DLC-1 3 4
  • DLC1 3 4
  • Deleted In Lung And Esophageal Cancer Protein 1 3
  • Deleted In Lung Cancer Protein 1 4
  • CFAP81 3
  • F56 3

External Ids for DLEC1 Gene

Previous GeneCards Identifiers for DLEC1 Gene

  • GC03M038095
  • GC03P037352
  • GC03P037893
  • GC03P038041
  • GC03P038055
  • GC03P038023

Summaries for DLEC1 Gene

Entrez Gene Summary for DLEC1 Gene

  • The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]

GeneCards Summary for DLEC1 Gene

DLEC1 (Deleted In Lung And Esophageal Cancer 1) is a Protein Coding gene. Diseases associated with DLEC1 include Esophageal Cancer and Lung Cancer.

UniProtKB/Swiss-Prot for DLEC1 Gene

  • May act as a tumor suppressor by inhibiting cell proliferation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLEC1 Gene

Genomics for DLEC1 Gene

Regulatory Elements for DLEC1 Gene

Enhancers for DLEC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G038037 1 ENCODE dbSUPER 8.8 +0.6 635 3.0 HDAC1 CTCF MXI1 SUZ12 ETV1 MAX SIN3A BMI1 RBBP5 ZBTB40 DLEC1 PLCD1 PPP2R2DP1
GH03G038163 2 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +128.6 128594 8.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 OXSR1 ACAA1 MYD88 C3orf35 GORASP1 SLC22A13 ACVR2B-AS1 VILL PLCD1 DLEC1
GH03G038268 0.4 Ensembl 4.3 +230.0 229996 0.8 SPI1 RNU6-235P XYLB MYD88 ACAA1 VILL DLEC1 GC03M038270 SLC22A13
GH03G038028 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -8.4 -8406 4.3 BCOR SUZ12 AGO1 MAX ZMYM3 ZNF48 EGR1 POLR2A RCOR1 FOS PLCD1 DLEC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DLEC1 on UCSC Golden Path with GeneCards custom track

Promoters for DLEC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150964 695 201 HDAC1 MXI1 SUZ12 ETV1 SIN3A BMI1 RBBP5 ZBTB40 POLR2A EZH2

Genomic Location for DLEC1 Gene

Chromosome:
3
Start:
38,038,605 bp from pter
End:
38,124,025 bp from pter
Size:
85,421 bases
Orientation:
Plus strand

Genomic View for DLEC1 Gene

Genes around DLEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEC1 Gene

Proteins for DLEC1 Gene

  • Protein details for DLEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y238-DLEC1_HUMAN
    Recommended name:
    Deleted in lung and esophageal cancer protein 1
    Protein Accession:
    Q9Y238
    Secondary Accessions:
    • Q9NSW0
    • Q9NTG5

    Protein attributes for DLEC1 Gene

    Size:
    1755 amino acids
    Molecular mass:
    195684 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70676.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB70884.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DLEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLEC1 Gene

Post-translational modifications for DLEC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DLEC1 Gene

Domains & Families for DLEC1 Gene

Protein Domains for DLEC1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DLEC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DLEC1 Gene

Function for DLEC1 Gene

Molecular function for DLEC1 Gene

GENATLAS Biochemistry:
gene deleted in lung cancer 1,esophaegus and kidney cancer cell lines,see TSG3C
UniProtKB/Swiss-Prot Function:
May act as a tumor suppressor by inhibiting cell proliferation.

Gene Ontology (GO) - Molecular Function for DLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DLEC1: view
genes like me logo Genes that share phenotypes with DLEC1: view

Human Phenotype Ontology for DLEC1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DLEC1 Gene

MGI Knock Outs for DLEC1:

Animal Model Products

CRISPR Products

miRNA for DLEC1 Gene

miRTarBase miRNAs that target DLEC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DLEC1 Gene

Localization for DLEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLEC1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLEC1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 10213508
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DLEC1: view

Pathways & Interactions for DLEC1 Gene

SuperPathways for DLEC1 Gene

No Data Available

Interacting Proteins for DLEC1 Gene

Selected Interacting proteins: Q9Y238-DLEC1_HUMAN for DLEC1 Gene via IID

Gene Ontology (GO) - Biological Process for DLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA,TAS --
genes like me logo Genes that share ontologies with DLEC1: view

No data available for Pathways by source and SIGNOR curated interactions for DLEC1 Gene

Drugs & Compounds for DLEC1 Gene

(1) Additional Compounds for DLEC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLEC1: view

Transcripts for DLEC1 Gene

Unigene Clusters for DLEC1 Gene

Deleted in lung and esophageal cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLEC1 Gene

No ASD Table

Relevant External Links for DLEC1 Gene

GeneLoc Exon Structure for
DLEC1
ECgene alternative splicing isoforms for
DLEC1

Expression for DLEC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLEC1 Gene

This gene is overexpressed in Testis (x9.1), Pituitary (x8.8), Fallopian Tube (x7.9), and Cervix - Endocervix (x4.6).

Protein differential expression in normal tissues from HIPED for DLEC1 Gene

This gene is overexpressed in Spleen (62.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DLEC1 Gene



Protein tissue co-expression partners for DLEC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DLEC1 Gene:

DLEC1

SOURCE GeneReport for Unigene cluster for DLEC1 Gene:

Hs.714499

mRNA Expression by UniProt/SwissProt for DLEC1 Gene:

Q9Y238-DLEC1_HUMAN
Tissue specificity: Expressed in all tissues examined. Expression is highest in prostate and testis.

Evidence on tissue expression from TISSUES for DLEC1 Gene

  • Lung(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DLEC1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • head
  • larynx
  • neck
  • vocal cord
Thorax:
  • esophagus
  • lung
Abdomen:
  • stomach
General:
  • skin
genes like me logo Genes that share expression patterns with DLEC1: view

Primer Products

Orthologs for DLEC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DLEC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLEC1 34 35
  • 98.54 (n)
dog
(Canis familiaris)
Mammalia DLEC1 34 35
  • 83.87 (n)
cow
(Bos Taurus)
Mammalia DLEC1 34 35
  • 83.19 (n)
mouse
(Mus musculus)
Mammalia Dlec1 34 16 35
  • 77.72 (n)
rat
(Rattus norvegicus)
Mammalia Dlec1 34
  • 77.59 (n)
oppossum
(Monodelphis domestica)
Mammalia DLEC1 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves DLEC1 34 35
  • 58.31 (n)
lizard
(Anolis carolinensis)
Reptilia DLEC1 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlec1 34
  • 55.68 (n)
zebrafish
(Danio rerio)
Actinopterygii dlec1 34 35
  • 51.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for DLEC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLEC1 Gene

ENSEMBL:
Gene Tree for DLEC1 (if available)
TreeFam:
Gene Tree for DLEC1 (if available)

Paralogs for DLEC1 Gene

Pseudogenes.org Pseudogenes for DLEC1 Gene

genes like me logo Genes that share paralogs with DLEC1: view

No data available for Paralogs for DLEC1 Gene

Variants for DLEC1 Gene

Sequence variations from dbSNP and Humsavar for DLEC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035908 A breast cancer sample
rs1000022673 -- 38,089,918(+) TCAGG(A/T)CTGTA intron-variant
rs1000027069 -- 38,098,528(+) CACCG(C/T)CCCTT intron-variant
rs1000058219 -- 38,098,810(+) CTTTA(A/C)CTGAT intron-variant
rs1000148225 -- 38,059,069(+) ATTAT(C/T)ACCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLEC1 Gene

Variant ID Type Subtype PubMed ID
esv1008921 CNV deletion 20482838
esv1683994 CNV deletion 17803354
esv2665102 CNV deletion 23128226
esv2669825 CNV deletion 23128226
esv2725160 CNV deletion 23290073
esv2759140 CNV loss 17122850
esv3383943 CNV duplication 20981092
esv3561755 CNV deletion 23714750
nsv1073217 CNV deletion 25765185
nsv1142356 CNV tandem duplication 24896259
nsv237307 CNV deletion 16902084
nsv428416 CNV loss 18775914
nsv508911 CNV insertion 20534489
nsv590101 CNV loss 21841781
nsv819131 CNV loss 19587683
nsv820288 CNV insertion 19587683

Variation tolerance for DLEC1 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.64; 91.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLEC1 Gene

Human Gene Mutation Database (HGMD)
DLEC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEC1 Gene

Disorders for DLEC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DLEC1 Gene - From: OMIM, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search DLEC1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DLEC1_HUMAN
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:10213508}. Note=The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription may be implicated in the development of esophageal cancer.
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer.
  • Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR).

Relevant External Links for DLEC1

Genetic Association Database (GAD)
DLEC1
Human Genome Epidemiology (HuGE) Navigator
DLEC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLEC1
genes like me logo Genes that share disorders with DLEC1: view

No data available for Genatlas for DLEC1 Gene

Publications for DLEC1 Gene

  1. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. (PMID: 10213508) Daigo Y. … Nakamura Y. (Cancer Res. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C. … Brennan P. (Cancer Res. 2009) 3 46 64
  4. Expression level and methylation status of three tumor suppressor genes, DLEC1, ITGA9 and MLH1, in non-small cell lung cancer. (PMID: 27287342) Pastuszak-Lewandoska D. … BrzeziaA8ska-Lasota E. (Med. Oncol. 2016) 3 64
  5. DLEC1 is not silenced solely by promoter methylation in head and neck squamous cell carcinoma. (PMID: 25746324) Seven D. … Buyru N. (Gene 2015) 3 64

Products for DLEC1 Gene

Sources for DLEC1 Gene

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