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Aliases for DLEC1 Gene

Aliases for DLEC1 Gene

  • Deleted In Lung And Esophageal Cancer 1 2 3
  • DLC1 3 4 6
  • Cilia And Flagella Associated Protein 81 2 3
  • DLC-1 3 4
  • Deleted In Lung And Esophageal Cancer 1 Transcript Varient 2 3
  • Deleted In Lung And Esophageal Cancer Protein 1 3
  • Deleted In Lung Cancer Protein 1 4
  • CFAP81 3
  • F56 3

External Ids for DLEC1 Gene

Summaries for DLEC1 Gene

Entrez Gene Summary for DLEC1 Gene

  • This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney. [provided by RefSeq, Jul 2008]

GeneCards Summary for DLEC1 Gene

DLEC1 (Deleted In Lung And Esophageal Cancer 1) is a Protein Coding gene. Diseases associated with DLEC1 include lung cancer and esophageal cancer. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of CDC42 activity.

UniProtKB/Swiss-Prot for DLEC1 Gene

  • May act as a tumor suppressor by inhibiting cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLEC1 Gene

Genomics for DLEC1 Gene

Genomic Location for DLEC1 Gene

Start:
38,039,006 bp from pter
End:
38,124,025 bp from pter
Size:
85,020 bases
Orientation:
Plus strand

Genomic View for DLEC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEC1 Gene

Regulatory Elements for DLEC1 Gene

Proteins for DLEC1 Gene

  • Protein details for DLEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y238-DLEC1_HUMAN
    Recommended name:
    Deleted in lung and esophageal cancer protein 1
    Protein Accession:
    Q9Y238
    Secondary Accessions:
    • Q9NSW0
    • Q9NTG5

    Protein attributes for DLEC1 Gene

    Size:
    1755 amino acids
    Molecular mass:
    195684 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70676.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB70884.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DLEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLEC1 Gene

Proteomics data for DLEC1 Gene at MOPED

Post-translational modifications for DLEC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLEC1 Gene

No data available for DME Specific Peptides for DLEC1 Gene

Domains for DLEC1 Gene

Protein Domains for DLEC1 Gene

ProtoNet:
genes like me logo Genes that share domains with DLEC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DLEC1 Gene

Function for DLEC1 Gene

Molecular function for DLEC1 Gene

GENATLAS Biochemistry: gene deleted in lung cancer 1,esophaegus and kidney cancer cell lines,see TSG3C
UniProtKB/Swiss-Prot Function: May act as a tumor suppressor by inhibiting cell proliferation.

Gene Ontology (GO) - Molecular Function for DLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DLEC1: view

Phenotypes for DLEC1 Gene

genes like me logo Genes that share phenotypes with DLEC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DLEC1 Gene

Localization for DLEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLEC1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLEC1 Gene COMPARTMENTS Subcellular localization image for DLEC1 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DLEC1: view

Pathways for DLEC1 Gene

genes like me logo Genes that share pathways with DLEC1: view

Pathways by source for DLEC1 Gene

Interacting Proteins for DLEC1 Gene

Gene Ontology (GO) - Biological Process for DLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 10213508
genes like me logo Genes that share ontologies with DLEC1: view

Compounds for DLEC1 Gene

(1) Novoseek inferred chemical compound relationships for DLEC1 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 60.5 1
genes like me logo Genes that share compounds with DLEC1: view

Transcripts for DLEC1 Gene

Unigene Clusters for DLEC1 Gene

Deleted in lung and esophageal cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLEC1 Gene

No ASD Table

Relevant External Links for DLEC1 Gene

GeneLoc Exon Structure for
DLEC1
ECgene alternative splicing isoforms for
DLEC1

Expression for DLEC1 Gene

mRNA expression in normal human tissues for DLEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLEC1 Gene

This gene is overexpressed in Testis (9.1), Pituitary (8.8), Fallopian Tube (7.9), and Cervix - Endocervix (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DLEC1 Gene

SOURCE GeneReport for Unigene cluster for DLEC1 Gene Hs.714499

mRNA Expression by UniProt/SwissProt for DLEC1 Gene

Q9Y238-DLEC1_HUMAN
Tissue specificity: Expressed in all tissues examined. Expression is highest in prostate and testis.
genes like me logo Genes that share expressions with DLEC1: view

Orthologs for DLEC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DLEC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLEC1 36
  • 98.54 (n)
  • 98.22 (a)
DLEC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DLEC1 36
  • 83.19 (n)
  • 78.29 (a)
DLEC1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLEC1 36
  • 83.87 (n)
  • 78.92 (a)
DLEC1 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlec1 36
  • 77.72 (n)
  • 72.85 (a)
Dlec1 16
Dlec1 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DLEC1 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 47 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dlec1 36
  • 77.59 (n)
  • 72.09 (a)
chicken
(Gallus gallus)
Aves DLEC1 36
  • 58.31 (n)
  • 49.02 (a)
DLEC1 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLEC1 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlec1 36
  • 55.68 (n)
  • 46.19 (a)
zebrafish
(Danio rerio)
Actinopterygii dlec1 36
  • 51.21 (n)
  • 41.85 (a)
dlec1 37
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToOne
Species with no ortholog for DLEC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLEC1 Gene

ENSEMBL:
Gene Tree for DLEC1 (if available)
TreeFam:
Gene Tree for DLEC1 (if available)

Paralogs for DLEC1 Gene

Pseudogenes.org Pseudogenes for DLEC1 Gene

genes like me logo Genes that share paralogs with DLEC1: view

No data available for Paralogs for DLEC1 Gene

Variants for DLEC1 Gene

Sequence variations from dbSNP and Humsavar for DLEC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs156266 -- 38,120,831(+) CCAGA(C/G)TGTGG intron-variant
rs189938 -- 38,116,073(+) AAAGC(G/T)GACAT intron-variant
rs199420 -- 38,122,171(+) ATCGC(C/G)TTGCA reference, synonymous-codon, intron-variant
rs202169 -- 38,098,920(+) TACTT(C/T)CCCTC intron-variant
rs202170 -- 38,099,346(+) GTCTA(A/G)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLEC1 Gene

Variant ID Type Subtype PubMed ID
dgv1447e1 CNV Complex 17122850
dgv1448e1 CNV Complex 17122850
nsv428416 CNV Loss 18775914
nsv508911 CNV Insertion 20534489
nsv819131 CNV Loss 19587683
nsv820288 CNV Insertion 19587683
esv2665102 CNV Deletion 23128226
esv2669825 CNV Deletion 23128226
nsv237307 CNV Loss 16902084
esv1008921 CNV Deletion 20482838
esv1683994 CNV Deletion 17803354
esv2725160 CNV Deletion 23290073

Relevant External Links for DLEC1 Gene

HapMap Linkage Disequilibrium report
DLEC1

Disorders for DLEC1 Gene

(2) OMIM Diseases for DLEC1 Gene (604050)

UniProtKB/Swiss-Prot

DLEC1_HUMAN
  • Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR).
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer.
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:10213508}. Note=The gene represented in this entry may be involved in disease pathogenesis. DLEC1 silencing due to promoter methylation and aberrant transcription may be implicated in the development of esophageal cancer.

(5) Novoseek inferred disease relationships for DLEC1 Gene

Disease -log(P) Hits PubMed IDs
prostate carcinoma 44.7 6
breast carcinoma 34 1
tumors 26.9 18
prostate cancer 16.9 2
cancer 6.93 6

Relevant External Links for DLEC1

Genetic Association Database (GAD)
DLEC1
Human Genome Epidemiology (HuGE) Navigator
DLEC1
genes like me logo Genes that share disorders with DLEC1: view

Publications for DLEC1 Gene

  1. Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. (PMID: 10213508) Daigo Y. … Nakamura Y. (Cancer Res. 1999) 2 3 4
  2. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C. … Brennan P. (Cancer Res. 2009) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Evidence of a tumour suppressor function for DLEC1 in human breast cancer. (PMID: 20530412) Al Sarakbi W. … Mokbel K. (Anticancer Res. 2010) 3
  5. Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer. (PMID: 20630829) Zhang Y. … Chen L. (Clin Lung Cancer 2010) 3

Products for DLEC1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DLEC1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DLEC1
    • Block miRNA regulation of DLEC1 using miScript Target Protectors

    Sources for DLEC1 Gene

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