Aliases for DLC1 Gene
- DLC1 Rho GTPase Activating Protein 2 3
- StAR-Related Lipid Transfer (START) Domain Containing 12 2 3
- Rho-Type GTPase-Activating Protein 7 3 4
- START Domain-Containing Protein 12 3 4
- Deleted In Liver Cancer 1 Protein 3 4
- ARHGAP7 3 4
- STARD12 3 4
- StAR-Related Lipid Transfer Protein 12 4
- Deleted In Liver Cancer 1 Variant 2 3
External Ids for DLC1 Gene
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
GeneCards Summary for DLC1 Gene
DLC1 (DLC1 Rho GTPase Activating Protein) is a Protein Coding gene. Diseases associated with DLC1 include colorectal cancer and lung cancer. Among its related pathways are Signaling by GPCR and G-protein signaling_Regulation of CDC42 activity. GO annotations related to this gene include SH2 domain binding. An important paralog of this gene is ARHGAP11A.
UniProtKB/Swiss-Prot for DLC1 Gene
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.