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DLC1 Gene

protein-coding GIFtS: 65

GC08M012985

deleted in liver cancer 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARHGAP7 ^¹, ², ³
DLC-1 ^¹
Dlc-1 ^³
FLJ21120 ^²
HP ^¹, ²
KIAA1723 ^³
OTTHUMP00000116050 ^²
STARD12 ^¹, ², ³
StARD12 ^³
p122-RhoGAP ^¹, ²

Descriptions
Deleted in liver cancer 1 protein ^³
HP protein ^³
Rho-GTPase-activating protein 7 ^²
Rho-type GTPase-activating protein 7 ^³
START domain containing protein 12 ^²
START domain-containing protein 12 ^³
StAR-related lipid transfer (START) domain containing 12 ^²
StAR-related lipid transfer protein 12 ^², ³
deleted in liver cancer 1 ^²
deleted in liver cancer 1 variant 2 ^²

External Ids
HGNC: 2897¹
Entrez Gene: 10395²
UniProtKB: Q96QB1³
Ensembl: ENSG00000164741⁷

Search outside databases for aliases for DLC1 gene

Previous GC identifers: GC08M012717 GC08M012901 GC08M012951

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DLC1:

This gene is deleted in the primary tumor of hepatocellular carcinoma. It maps to 8p22-p21.3, a

region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor

suppressor gene for human liver cancer, as well as for prostate, lung, colorectal, and breast

cancers. Alternative splicing at this locus results in several transcript variants encoding

different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: RHG07_HUMAN, Q96QB1

Function: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in

vivo and induces morphological changes and detachment through cytoskeletal reorganization (By

similarity)

Gene Wiki entry for DLC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DLC1 gene

Entrez Gene cytogenetic band: 8p22 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22

DLC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M012985: (about GC identifiers)

Start:	12,985,243 bp from pter
End:	13,416,766 bp from pter
Size:	431,524 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_030737.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RHG07_HUMAN, Q96QB1 (See protein sequence)

Recommended Name: Rho GTPase-activating protein 7

Size: 1091 amino acids; 122827 Da

Subcellular location: Cytoplasm (Potential)

Sequence caution: Sequence=BAB21814.1; Type=Miscellaneous discrepancy; Note=Chimera. Sequence from

position 1 to 13 is due to a chimera;

PDB structure from and Proteopedia :

2DKY (3D)

2GYT (3D)

Secondary accessions: O14868 O43199 Q9C0E0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_006085.2 NP_079043.2 NP_872584.1

ENSEMBL proteins:

ENSP00000321034 ENSP00000351797 ENSP00000276297

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DLC1)
	Human Recombinant Proteins from Abnova (DLC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	17888903
GO:0005737	cytoplasm	IDA	16951145 17888903
GO:0005901	caveola	IPI	16951145
GO:0005925	focal adhesion	IDA	16951145 17190795

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Antibodies for DLC1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DLC1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DLC1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DLC1)
	Novus Biologicals Antibodies for DLC1

Assays for DLC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96QB1

ProtoNet protein and cluster: Q96QB1

4 Blocks protein families:

IPB000198 RhoGAP domain

IPB001660 Sterile alpha motif SAM

IPB002913 Lipid-binding START

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: RHG07_HUMAN, Q96QB1

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

Similarity: Contains 1 START domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DLC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_182643

Applied Biosystems Silencer® siRNAs for DLC1

Sigma-Aldrich siRNA for DLC1

Sigma-Aldrich shRNA for DLC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DLC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006094
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006094
untagged cDNA clones in CMV expression vector (see all 4): NM_006094

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_182643

UniProtKB/Swiss-Prot: RHG07_HUMAN, Q96QB1

Function: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in

vivo and induces morphological changes and detachment through cytoskeletal reorganization (By

gene deleted in liver cancer 1,ubiquitously expressed in normal tissues,homolog to rat RhoGAP (see

TSG8D),not a target of 8pLOH in colorectal or ovarian tumors

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dlc1):

	cellular	craniofacial	embryogenesis	lethality-prenatal/perinatal
nervous system	normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--
GO:0005515	protein binding	IPI	16951145
GO:0030675	NOT Rac GTPase activator activity	IDA	17932950
GO:0042169	SH2 domain binding	IPI	17190795

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for DLC1 (Your Favorite Gene powered by Ingenuity)

Leukocyte Extravasation Signaling

GeneDecks DLC1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DLC1

5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001843	neural tube closure	ISS	--
GO:0003007	heart morphogenesis	ISS	--
GO:0006917	induction of apoptosis	IDA	17292327 17888903
GO:0006919	activation of caspase activity	IDA	17888903
GO:0007165	signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DLC1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DLC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_182643

Sigma-Aldrich siRNA for DLC1

Sigma-Aldrich shRNA for DLC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006094 NM_024767 NM_182643

REFSEQ mRNAs for DLC1 gene (3 alternative transcripts):

NM_006094.3 NM_024767.2 NM_182643.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006094 NM_024767 NM_182643

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_006094
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_006094
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_006094

Additional cDNA sequence:

AB051510.1 AF026219.1 AF035119.1 AK023128.1 AK024773.1 AK025544.1 AK025733.1 AK225098.1

AK289734.1 AK291682.1 AK299049.1 AL117604.1 BC049842.1 BC054511.1 BC095415.1 DQ092382.1

DQ092383.1 EU159199.1 EU159200.1

19 DOTS entries:

DT.92430630 DT.120650456 DT.100785019 DT.100785020 DT.65284749 DT.100785021 DT.100785015 DT.100691378

DT.120650387 DT.120650450 DT.120650484 DT.120650423 DT.120650427 DT.120650453 DT.120650503 DT.92430627

DT.121366457 DT.95278357 DT.99971511

24/312 AceView cDNA sequences (see all 312 ):

AI493763 T36042 BC049842 CA444625 BU754387 BU788981 AA485481 BQ709121

BQ003744 BX474620 BU626636 AA485324 AI569298 AI139143 AU119481 AI350839

Z40259 AA664020 AA669172 BM702719 AI537946 BF724250 NM_182643 AI334360

highest scoring ESTs for DLC1:

AA418047 AA418218 AA446780 AB051510 AF035119 AI334360 AI829459 AK024773 AL708548 BC049842

Unigene Cluster for DLC1:

Deleted in liver cancer 1

Hs.134296 [show with all ESTs]

Unigene Representative Sequence: NM_182643

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DLC1 (see all 7 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12	^	13a	·	13b	·	13c	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^
SP1:																																			-
SP2:
SP3:
SP4:																			-
SP5:																	-

ExUns:	21
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DLC1

3 Ensembl transcripts including schematic representations:

ENST00000316609 ENST00000358919 ENST00000276297

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DLC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DLC1

¹ / ² / ³

15 probe-sets matching DLC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37951_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.79	AF035119	0.80	1.00	0.91	1
71123_at²^{, 3}	U95-D	1	1.00	1.00	0.69	0.86	AI829459	0.80	1.00	0.91	1
64873_at²^{, 3}	U95-C	1	1.00	1.00	0.76	1.30	AI334360	0.80	1.00	0.91	1
46303_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.48	AA524250	0.60	1.00	0.82	1
49889_at²^{, 3}	U95-C	1	0.94	1.00	0.45	0.65	AA418047	0.80	1.00	0.91	1
220512_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024767	0.60	1.00	0.82	1
210762_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF026219	0.60	1.00	0.82	1
224822_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA524250	0.60	1.00	0.82	1
242631_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF476660	0.60	1.00	0.82	1
220511_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024767	0.60	1.00	0.82	1
220512_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210762_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224822_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242631_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220511_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DLC1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGCTGGAGA

SOURCE GeneReport for Unigene cluster: Hs.134296
Expression variation in blood from EXPOLDB for DLC1
UniProtKB/Swiss-Prot: RHG07_HUMAN, Q96QB1
Tissue specificity: Highest level of expression in the spleen, with rather lower levels in
prostate, testis, ovary, small intestine and colon, but none in the thymus

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DLC1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DLC1¹	--	deleted in liver cancer 1	85.14(n) 89.4(a)	475607 XM_532822.2 XP_532822.2
chimpanzee (Pan troglodytes)	DLC1¹	--	deleted in liver cancer 1	99.17(n) 98.81(a)	464001 XM_001139365.1 XP_001139365.1
mouse (Mus musculus)	Dlc1^{1, 5}	8 (21.00 cM)⁵	deleted in liver cancer 1^{1, 5}	86.55(n)¹ 92.95(a)¹	50768¹ NM_015802.2¹ NP_056617.2¹ AA895275⁵ AF178078⁵ (see all 27)
chicken (Gallus gallus)	DLC1¹	--	deleted in liver cancer 1	74.72(n) 76.16(a)	422740 XM_420693.2 XP_420693.2
zebrafish (Danio rerio)	LOC567965¹	--	similar to deleted in liver cancer 1	64.2(n) 66.86(a)	567965 XM_001921739.1 XP_001921774.1

About this table Species with no ortholog for DLC1

ENSEMBL Gene Tree for DLC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DLC1 gene

STARD13² STARD8² RP13-102H20.1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/3487 NCBI SNPs in DLC1 are shown (see all 3487 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1248)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1383942^1,2	A,C,F,H,O	13401958(+)	`TCATCA/GTAGTT`	2	--	ut5¹		15	NS MN NA EU EA WA	1032
	rs532841^1,2	A,C,F,H	13001846(+)	`CTCCAC/TCACGT`	2	V/M	mis¹		18	EA NA MN EU WA	2850
	rs486596^1,2	C,F,H,O	12986881(+)	`AGGCTG/AGAGGG`	2	--	ut3¹ ese³		8	MN NA EU EA WA	742
	rs3816747^1,2	A,C,F,H	13401173(+)	`AAGGAA/GTATCC`	2	T/I	mis¹ ese³		12	EU EA WA	1256
	rs6531026^1,2	A,C,F,H	13035996(+)	`ctcagA/Ttgatt`	2	--	int¹ ng3¹		4	EU EA WA	416
--	rs11203495^1,2	A,C,F,H	13401190(+)	`TCATTG/TTGTAC`	2	Q/H	mis¹		7	EU EA WA	696
	rs1044011^1,2	A,C,F,H	12986080(-)	`AGATTG/TTATGT`	2	--	ut3¹		16	MN NA EU EA WA	1536
	rs10888175^1,2	A,C,F,H	12987436(+)	`GCAATC/TTGAAT`	2	--	ut3¹		4	EU EA WA	410
	rs2062070^1,2	C,F,H	13417309(+)	`TAGTTT/CGTGTT`	2	--	ng3¹		4	EU EA WA	418
	rs3816748^1,2	C,F,H	13401711(+)	`TGAAAG/CATGAC`	2	V/L	mis¹		12	NA EU EA WA	1020

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HapMap Linkage Disequilibrium images for DLC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604258

4 Novoseek disease relationships for DLC1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	58.11	19	16204057 (5), 17292327 (3), 12792785 (2), 14647417 (2) (see all 8)
tumors	34.80	39	17029774 (5), 12792785 (5), 16204057 (4), 17016643 (4) (see all 12)
cancer	31.76	16	16204057 (2), 17979893 (2), 17297465 (1), 17016643 (1) (see all 9)
breast cancer	19.19	2	17016643 (1)

About this table

Genetic Association Database: DLC1
Human Genome Epidemiology Navigator: DLC1 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/53 PubMed articles for DLC1 gene (see all 53 ):

Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. (PubMed id 9605766)^{1, 2, 3, 4} Yuan B.Z....Popescu N.C. (1998)
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{2, 3, 4} Nagase T....Ohara O. (2000)
Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study. (PubMed id 12873722)^{3, 6} Zheng S.L....Xu J. (2003)
Sequence variants of DLC1 in colorectal and ovarian tumours. (PubMed id 10649492)^{3, 4} Wilson P.J.... Chenevix-Trench G. (2000)
Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. (PubMed id 12813468)^{1, 3} Kim T.Y....Bang Y.J. (2003)
Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. (PubMed id 14633684)^{1, 3} Wong C.M....Ng I.O. (2003)
Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. (PubMed id 14647417)^{1, 3} Zhou X....Popescu N.C. (2004)
Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas. (PubMed id 17965626)^{1, 3} Ying J....Tao Q. (2007)
DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. (PubMed id 17292327)^{1, 3} Kim T.Y....Bang Y.J. (2007)
DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. (PubMed id 12792785)^{1, 3} Park S.W....Popescu N.C. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10395	HGNC: 2897	AceView: DLC1	Ensembl:ENSG00000164741	euGenes: HUgn10395
ECgene: DLC1	H-InvDB: DLC1

(According to HUGE)
About This Section

HUGE: KIAA1723

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DLC1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DLC1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DLC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DLC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DLC1		Antibodies for DLC1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DLC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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DLC1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for DLC1

Summaries
for DLC1

Genomic Location
for DLC1

Proteins
for DLC1

Protein Domains/
Families
for DLC1

Gene Function
for DLC1

Pathways & Interactions
for DLC1

Drugs & Compounds
for DLC1

Transcripts
for DLC1

Expression
for DLC1

Orthologs
for DLC1

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for DLC1

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for DLC1

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for DLC1

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for DLC1

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for DLC1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DLC1 (Gene Symbol)
ARHGAP7
DLC-1
Dlc-1
FLJ21120
HP
KIAA1723
OTTHUMP00000116050
STARD12
StARD12
p122-RhoGAP
Deleted in liver cancer 1 protein
HP protein
Rho-GTPase-activating protein 7
Rho-type GTPase-activating protein 7
START domain containing protein 12
START domain-containing protein 12
StAR-related lipid transfer (START) domain containing 12
StAR-related lipid transfer protein 12
deleted in liver cancer 1
deleted in liver cancer 1 variant 2

DLC1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor DLC1

Summariesfor DLC1

Genomic Locationfor DLC1

Proteinsfor DLC1

Protein Domains/Familiesfor DLC1

Gene Functionfor DLC1

Pathways & Interactionsfor DLC1

Drugs & Compoundsfor DLC1

Transcriptsfor DLC1

Expression for DLC1

Orthologsfor DLC1

Paralogsfor DLC1

SNPs/Variantsfor DLC1

Disorders & Mutationsfor DLC1

Medical Newsfor DLC1

Publicationsfor DLC1

Search for DLC1

Genome Databases showing DLC1

Other Databases showing DLC1

Specialized Databases showing DLC1

Licensable Technologiesfor DLC1

Servicesfor DLC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DLC1

Summaries
for DLC1

Genomic Location
for DLC1

Proteins
for DLC1

Protein Domains/
Families
for DLC1

Gene Function
for DLC1

Pathways & Interactions
for DLC1

Drugs & Compounds
for DLC1

Transcripts
for DLC1

Expression
for DLC1

Orthologs
for DLC1

Paralogs
for DLC1

SNPs/Variants
for DLC1

Disorders & Mutations
for DLC1

Medical News
for DLC1

Publications
for DLC1

Licensable Technologies
for DLC1

Services
for DLC1