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Aliases for DLC1 Gene

Aliases for DLC1 Gene

  • DLC1 Rho GTPase Activating Protein 2 3 5
  • StAR-Related Lipid Transfer (START) Domain Containing 12 2 3
  • Rho-Type GTPase-Activating Protein 7 3 4
  • START Domain-Containing Protein 12 3 4
  • Deleted In Liver Cancer 1 Protein 3 4
  • ARHGAP7 3 4
  • STARD12 3 4
  • StAR-Related Lipid Transfer Protein 12 4
  • Deleted In Liver Cancer 1 Variant 2 3
  • Rho-GTPase-Activating Protein 7 3
  • Deleted In Liver Cancer 1 2
  • P122-RhoGAP 3
  • HP Protein 4
  • KIAA1723 4
  • DLC-1 4
  • HP 3

External Ids for DLC1 Gene

Previous GeneCards Identifiers for DLC1 Gene

  • GC08M012717
  • GC08M012901
  • GC08M012951
  • GC08M012985
  • GC08M011483
  • GC08M012940

Summaries for DLC1 Gene

Entrez Gene Summary for DLC1 Gene

  • This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

GeneCards Summary for DLC1 Gene

DLC1 (DLC1 Rho GTPase Activating Protein) is a Protein Coding gene. Diseases associated with DLC1 include Colorectal Cancer and Esophageal Cancer. Among its related pathways are Signaling by Rho GTPases and Regulation of RhoA activity. GO annotations related to this gene include GTPase activator activity and SH2 domain binding. An important paralog of this gene is ARHGAP11A.

UniProtKB/Swiss-Prot for DLC1 Gene

  • Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Gene Wiki entry for DLC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLC1 Gene

Genomics for DLC1 Gene

Regulatory Elements for DLC1 Gene

Enhancers for DLC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DLC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DLC1 Gene

Chromosome:
8
Start:
13,083,361 bp from pter
End:
13,604,610 bp from pter
Size:
521,250 bases
Orientation:
Minus strand

Genomic View for DLC1 Gene

Genes around DLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLC1 Gene

Proteins for DLC1 Gene

  • Protein details for DLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QB1-RHG07_HUMAN
    Recommended name:
    Rho GTPase-activating protein 7
    Protein Accession:
    Q96QB1
    Secondary Accessions:
    • B4DR10
    • B8PTI0
    • E9PDZ8
    • E9PF76
    • E9PGY9
    • O14868
    • O43199
    • Q7Z5R8
    • Q86UC6
    • Q9C0E0
    • Q9H7A2

    Protein attributes for DLC1 Gene

    Size:
    1528 amino acids
    Molecular mass:
    170591 Da
    Quaternary structure:
    • Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
    SequenceCaution:
    • Sequence=AAB81637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB21814.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DLC1 Gene

    Alternative splice isoforms for DLC1 Gene

neXtProt entry for DLC1 Gene

Proteomics data for DLC1 Gene at MOPED

Post-translational modifications for DLC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DLC1 Gene

Domains & Families for DLC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96QB1

UniProtKB/Swiss-Prot:

RHG07_HUMAN :
  • The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity.
Domain:
  • The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity.
  • The polybasic cluster is required for activation and mediates binding to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)) containing membranes.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 START domain.
genes like me logo Genes that share domains with DLC1: view

Function for DLC1 Gene

Molecular function for DLC1 Gene

GENATLAS Biochemistry:
gene deleted in liver cancer 1,ubiquitously expressed in normal tissues,homolog to rat RhoGAP (see TSG8D),not a target of 8pLOH in colorectal or ovarian tumors
UniProtKB/Swiss-Prot Function:
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Gene Ontology (GO) - Molecular Function for DLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP,TAS --
genes like me logo Genes that share ontologies with DLC1: view
genes like me logo Genes that share phenotypes with DLC1: view

Human Phenotype Ontology for DLC1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DLC1 Gene

MGI Knock Outs for DLC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DLC1

miRNA for DLC1 Gene

miRTarBase miRNAs that target DLC1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DLC1 Gene

Localization for DLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLC1 Gene

Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DLC1 Gene COMPARTMENTS Subcellular localization image for DLC1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for DLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030864 cortical actin cytoskeleton IDA 19158340
GO:0032587 ruffle membrane IDA 19158340
genes like me logo Genes that share ontologies with DLC1: view

Pathways & Interactions for DLC1 Gene

genes like me logo Genes that share pathways with DLC1: view

Pathways by source for DLC1 Gene

1 GeneTex pathway for DLC1 Gene
1 BioSystems pathway for DLC1 Gene
1 GeneGo (Thomson Reuters) pathway for DLC1 Gene

SIGNOR curated interactions for DLC1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure ISS --
GO:0006915 apoptotic process IDA 17292327
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17888903
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with DLC1: view

Drugs & Compounds for DLC1 Gene

No Compound Related Data Available

Transcripts for DLC1 Gene

Unigene Clusters for DLC1 Gene

Deleted in liver cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DLC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6: - - -
SP7:

ExUns: 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DLC1 Gene

GeneLoc Exon Structure for
DLC1
ECgene alternative splicing isoforms for
DLC1

Expression for DLC1 Gene

mRNA expression in normal human tissues for DLC1 Gene

Protein differential expression in normal tissues from HIPED for DLC1 Gene

This gene is overexpressed in Heart (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DLC1 Gene



SOURCE GeneReport for Unigene cluster for DLC1 Gene Hs.134296

mRNA Expression by UniProt/SwissProt for DLC1 Gene

Q96QB1-RHG07_HUMAN
Tissue specificity: Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.
genes like me logo Genes that share expression patterns with DLC1: view

Protein tissue co-expression partners for DLC1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for DLC1 Gene

Orthologs for DLC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DLC1 35
  • 89.13 (n)
  • 93.79 (a)
DLC1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLC1 35
  • 89.87 (n)
  • 94.53 (a)
DLC1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dlc1 35
  • 83.9 (n)
  • 84.84 (a)
Dlc1 16
Dlc1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DLC1 35
  • 98.88 (n)
  • 98.6 (a)
DLC1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dlc1 35
  • 86.19 (n)
  • 92.77 (a)
oppossum
(Monodelphis domestica)
Mammalia DLC1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DLC1 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLC1 35
  • 74.75 (n)
  • 76.16 (a)
DLC1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLC1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dlc1 35
  • 70.72 (n)
  • 75.41 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC567965 35
  • 62.82 (n)
  • 65.24 (a)
DLC1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP88C 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea gei-1 37
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4228 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for DLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DLC1 Gene

ENSEMBL:
Gene Tree for DLC1 (if available)
TreeFam:
Gene Tree for DLC1 (if available)

Paralogs for DLC1 Gene

(3) SIMAP similar genes for DLC1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DLC1: view

Variants for DLC1 Gene

Sequence variations from dbSNP and Humsavar for DLC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1044092 - 13,100,202(-) GCTCA(A/G)CTGCG reference, missense
rs532841 - 13,099,966(+) CTCCA(C/T)CACGT reference, missense
VAR_014231 -
rs149295187 - 13,098,572(+) AGTCG(A/C/G)TGCCT reference, missense
VAR_014233 -

Structural Variations from Database of Genomic Variants (DGV) for DLC1 Gene

Variant ID Type Subtype PubMed ID
nsv890389 CNV Loss 21882294
esv271876 CNV Insertion 20981092
nsv6084 CNV Insertion 18451855
esv2669734 CNV Deletion 23128226
esv275220 CNV Gain+Loss 21479260
nsv890390 CNV Loss 21882294
nsv8290 CNV Gain 18304495
nsv521822 CNV Loss 19592680
nsv890391 CNV Loss 21882294
esv2651648 CNV Deletion 19546169
esv1980179 CNV Deletion 18987734
esv2736632 CNV Deletion 23290073
nsv890392 CNV Loss 21882294
nsv516894 CNV Gain 19592680
esv2676326 CNV Deletion 23128226
nsv516452 CNV Loss 19592680
nsv890393 CNV Loss 21882294
esv2752209 CNV Loss 17911159
nsv890394 CNV Gain 21882294
nsv465470 CNV Loss 19166990
nsv470184 CNV Loss 18288195
nsv465471 CNV Loss 19166990
nsv6085 CNV Insertion 18451855
esv2736633 CNV Deletion 23290073
nsv397643 CNV Loss 16902084
nsv397741 CNV Loss 16902084
esv2667120 CNV Deletion 23128226
esv2736634 CNV Deletion 23290073
nsv465473 CNV Loss 19166990
nsv890395 CNV Gain 21882294
nsv517019 CNV Gain+Loss 19592680

Variation tolerance for DLC1 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DLC1 Gene

Human Gene Mutation Database (HGMD)
DLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLC1 Gene

Disorders for DLC1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DLC1 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
esophageal cancer
  • esophageal cancer, somatic
lung cancer
  • lung cancer, protection against
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search DLC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DLC1

Genetic Association Database (GAD)
DLC1
Human Genome Epidemiology (HuGE) Navigator
DLC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DLC1
genes like me logo Genes that share disorders with DLC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DLC1 Gene

Publications for DLC1 Gene

  1. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. (PMID: 9605766) Yuan B.Z. … Popescu N.C. (Cancer Res. 1998) 2 3 4 23 67
  2. Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics. (PMID: 20198346) Zhou X. … Popescu N.C. (Int. J. Oncol. 2010) 3 23
  3. DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. (PMID: 17932950) Healy K.D. … Der C.J. (Mol. Carcinog. 2008) 3 23
  4. DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. (PMID: 17292327) Kim T.Y. … Bang Y.J. (Biochem. Biophys. Res. Commun. 2007) 3 23
  5. Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas. (PMID: 17965626) Ying J. … Tao Q. (Epigenetics 2007) 3 23

Products for DLC1 Gene

Sources for DLC1 Gene

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