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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DKKL1 Gene

protein-coding GIFtS: 48
GCID: GC19P049871

dickkopf-like 1

(Previous name: dickkopf-like 1 (soggy) )

Search for DKKL1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dickkopf-Like 1¹ ²		SGY² ⁵
CT34¹ ² ³		Dickkopf-Like 1 (Soggy)¹
SGY-1¹ ² ³		Dickkopf-Like Protein 1²
SGY1² ³ ⁵		Soggy¹
Cancer/Testis Antigen 34² ³		Soggy-1¹
Protein Soggy-1² ³

External Ids:	HGNC: 16528¹	Entrez Gene: 27120²	Ensembl: ENSG00000104901⁷	OMIM: 605418⁵	UniProtKB: Q9UK85³

Export aliases for DKKL1 gene to outside databases

Previous GC identifers: GC19P054559 GC19P046243

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DKKL1:

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved

cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3

protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

(provided by RefSeq, Oct 2010)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DKKL1 gene promoter:
TBP HSF1 (long) MyoD MZF-1 CREB FAC1 deltaCREB HSF1short
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DKKL1 promoter sequence

Search SABiosciences Chromatin IP Primers for DKKL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKKL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3

DKKL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKKL1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P049871: view genomic region (about GC identifiers)

Start:	49,867,042 bp from pter	End:	49,878,373 bp from pter
Size:	11,332 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DKKL1_HUMAN, Q9UK85 (See protein sequence)

Recommended Name: Dickkopf-like protein 1 precursor

Size: 242 amino acids; 27007 Da

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for DKKL1: NX_Q9UK85

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UK85

DKKL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001184230.1 NP_001184231.1 NP_055234.1

ENSEMBL proteins:

ENSP00000221498

Human Recombinant Protein Products for DKKL1:

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	10570958

DKKL1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9UK85

UniProtKB/Swiss-Prot: DKKL1_HUMAN, Q9UK85

Similarity: To the N-terminal section of DKK-3

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	10570958
GO:0005515	protein binding	--	--

DKKL1 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dkkl1):

endocrine/exocrine gland

reproductive system

skeleton

DKKL1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Dkkl1^tm1.1Mldp for DKKL1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DKKL1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKKL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DKKL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for DKKL1 (Q9UK85³ ENSP00000221498⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519³, ENSP00000361423⁴	I2D: score=1 STRING: ENSP00000361423
CRK	P46108³, ENSP00000300574⁴	I2D: score=1 STRING: ENSP00000300574
FYN	P06241³, ENSP00000357656⁴	I2D: score=1 STRING: ENSP00000357656
SCFD1	Q8WVM8³, ENSP00000390783⁴	I2D: score=1 STRING: ENSP00000390783
C11orf71	ENSP00000325508⁴	STRING: ENSP00000325508

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	10570958
GO:0009653	anatomical structure morphogenesis	TAS	10570958
GO:0045600	positive regulation of fat cell differentiation	IEA	--

DKKL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DKKL1
Search CenterWatch for drugs/clinical trials and news about DKKL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for DKKL1 gene (3 alternative transcripts):

NM_001197301.1 NM_001197302.1 NM_014419.3

Unigene Cluster for DKKL1:

Dickkopf-like 1

Hs.515855 [show with all ESTs]

Unigene Representative Sequence: AY358922

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000221498(uc021uxk.1 uc002pnk.3 uc021uxl.1)

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		hsa-miR-587
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Additional cDNA sequence:

AF177398.1 AY358922.1 BC030581.2

5 DOTS entries:

DT.208577 DT.100746257 DT.100034189 DT.95366122 DT.95366125

4 AceView cDNA sequences:

NM_014419 AY358922 BC030581 AF177398

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DKKL1 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d
SP1:			-		-		-		-								-
SP2:									-								-
SP3:																	-
SP4:
SP5:															-		-

ECgene alternative splicing isoforms for DKKL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DKKL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTTCCGGG

About this image

DKKL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

ES-J1 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Long-time differentiated EBs (Derivation of embryo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DKKL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DKKL1

SOURCE GeneReport for Unigene cluster: Hs.515855

SABiosciences Custom PCR Arrays for DKKL1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for DKKL1 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dkkl1^{1 , 5}	dickkopf-like 1^{1, 5}	74.34(n)¹ 65.04(a)¹		7 (29.19 cM)⁵ 50722¹ NM_015789.3¹ NP_056604.2¹ 45207525⁵

ENSEMBL Gene Tree for DKKL1 (if available)
TreeFam Gene Tree for DKKL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DKKL1 gene

DKKL1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DKKL1
PGOHUM00000247640

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79220639^1,2	F	--	49867735(+)	`GTGGGA/TGTTGC`	3	--	int¹		1		WA	118
rs2303757^1,2	C,F,H	--	49867899(+)	`TACCCT/GGGTGA`	5	/R /L	mis¹ ut5¹ ese³		7		NS EA NA	516
rs116223719^1,2	C,F	--	49867912(+)	`CCCTCC/TGCTGC`	5	S	ut5¹ syn¹		2		WA NA	4654
rs919364^1,2	C,F,O,A,H	--	49867913(+)	`CCTCCG/ACTGCA`	5	/T /A	mis¹ ut5¹ ese³		31		NA EA MN NS WA CSA EU	9225
rs141910577^1,2	C	--	49867984(+)	`CTACTC/TCAAGG`	5	L	syn¹ ut5¹		1		EU	1323
rs199831575^1,2		--	49867997(+)	`TCAGCC/TGACTT`	5	R *	stg¹ ut5¹		0	--	--	--	--
rs147276980^1,2	C	--	49868034(+)	`GATGGA/GGGAAG`	3	--	int¹		0	--	--	--	--
rs140685187^1,2	C	--	49868036(+)	`TGGGGG/AAAGAA`	3	--	int¹		1		EU	1323
rs190836480^1,2		--	49868085(+)	`GTTCAA/GGGCCA`	3	--	int¹		0	--	--	--	--
rs143002502^1,2		--	49868307(+)	`AATCCA/CAGCTG`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DKKL1 (49867042 - 49878373 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DKKL1
2 CNVs: 5110 32261

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DKKL1 for disorders About MalaCards

DKKL1 for disorders About GeneDecksing

OMIM gene information: 605418 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: DKKL1 (1 document)

Export disorders for DKKL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DKKL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DKKL1)

Utopia: connect your pdf to the dynamic
world of online information

Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)^{1, 2, 3} Krupnik V.E.... McCarthy S.A. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Developmental expression and function of DKKL1/Dkkl1 i n humans and mice. (PubMed id 22817830)¹ Yan Q....Cai Z. (2012)
Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)¹ ....Compston A. (2011)
The multi-copy mouse gene Sycp3-like Y-linked (Sly) e ncodes an abundant spermatid protein that interacts with a histone acetyltransf erase and an acrosomal protein. (PubMed id 19176879)¹ Reynard L.N....Burgoyne P.S. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)¹ Wu C....Li S.S. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)¹ Olsen J.V....Mann M. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 27120	HGNC: 16528	AceView: DKKL1	Ensembl:ENSG00000104901	euGenes: HUgn27120
ECgene: DKKL1	H-InvDB: DKKL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DKKL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DKKL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DKKL1 gene:
Search GeneIP for patents involving DKKL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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	Browse OriGene Antibodies		OriGene shRNA RFP for DKKL1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DKKL1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKKL1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DKKL1

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DKKL1 gene at Home site.

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DKKL1 Gene

dickkopf-like 1

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DKKL1 Gene

dickkopf-like 1

Aliasesfor DKKL1 gene

Summariesfor DKKL1 gene

Genomic Viewsfor DKKL1 gene

Proteinsfor DKKL1 gene

Protein Domains /Familiesfor DKKL1 gene

Functionfor DKKL1 gene

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Expression for DKKL1 gene

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External Searches for DKKL1 gene

Genome Databases showing DKKL1 gene

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Specialized Databases showing DKKL1 gene

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Aliases
for DKKL1 gene

Summaries
for DKKL1 gene

Genomic Views
for DKKL1 gene

Proteins
for DKKL1 gene

Protein Domains /
Families
for DKKL1 gene

Function
for DKKL1 gene

Pathways & Interactions
for DKKL1 gene

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for DKKL1 gene

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for DKKL1 gene

Expression
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Orthologs
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Publications
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Intellectual Property
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