Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DKKL1 Gene

Aliases for DKKL1 Gene

  • Dickkopf Like Acrosomal Protein 1 2 3 5
  • Cancer/Testis Antigen 34 2 3 4
  • Dickkopf-Like 1 2 3
  • Protein Soggy-1 3 4
  • Soggy 2 3
  • SGY-1 3 4
  • CT34 3 4
  • SGY1 3 4
  • Testicular Secretory Protein Li 15 3
  • Dickkopf-Like Protein 1 3
  • Soggy-1 3
  • SGY 3

External Ids for DKKL1 Gene

Previous GeneCards Identifiers for DKKL1 Gene

  • GC19P054559
  • GC19P049871
  • GC19P046243

Summaries for DKKL1 Gene

Entrez Gene Summary for DKKL1 Gene

  • The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for DKKL1 Gene

DKKL1 (Dickkopf Like Acrosomal Protein 1) is a Protein Coding gene. Diseases associated with DKKL1 include Rectal Neoplasm. GO annotations related to this gene include signal transducer activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKKL1 Gene

Genomics for DKKL1 Gene

Regulatory Elements for DKKL1 Gene

Enhancers for DKKL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F049332 1.3 FANTOM5 ENCODE 39.8 -25.1 -25136 5.0 HDGF TBP HDAC1 TBL1XR1 WRNIP1 YBX1 ZBTB40 ELK1 ZNF143 ETV6 DKKL1 CCDC155 CD37 ALDH16A1 BCL2L12 FLT3LG IRF3 SNRNP70 ENSG00000197813
GH19F049359 1.1 ENCODE 41.9 +1.8 1837 4.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 DKKL1 CCDC155 GRWD1 AKT1S1 NUP62 LOC400710 TEAD2
GH19F049390 1.2 Ensembl ENCODE 34.2 +31.0 30957 1.9 HDGF PKNOX1 ARNT ARID4B YBX1 ZNF2 ZNF143 DEK SP3 JUNB CCDC155 DKKL1 BCL2L12 GC19P049399 PIR32242
GH19F049387 0.8 ENCODE 35.7 +27.7 27681 0.7 BCOR POLR2A ADNP TRIM24 E2F6 SMARCA5 ZNF740 L3MBTL2 RNF2 ZBTB2 CCDC155 DKKL1 LOC101928295
GH19F049301 1.1 Ensembl ENCODE 24.7 -59.0 -58995 1.0 HDAC1 ATF1 PKNOX1 CREB3L1 ZNF2 RAD21 ZNF121 ZNF143 CREM ZNF654 DKKL1 CCDC155 MIR4324 PIR36926
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DKKL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DKKL1 Gene

Chromosome:
19
Start:
49,360,495 bp from pter
End:
49,375,119 bp from pter
Size:
14,625 bases
Orientation:
Plus strand

Genomic View for DKKL1 Gene

Genes around DKKL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKKL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKKL1 Gene

Proteins for DKKL1 Gene

  • Protein details for DKKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK85-DKKL1_HUMAN
    Recommended name:
    Dickkopf-like protein 1
    Protein Accession:
    Q9UK85

    Protein attributes for DKKL1 Gene

    Size:
    242 amino acids
    Molecular mass:
    27007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DKKL1 Gene

Post-translational modifications for DKKL1 Gene

Antibody Products

  • R&D Systems Antibodies for DKKL1 (Soggy-1/DkkL1)

No data available for DME Specific Peptides for DKKL1 Gene

Domains & Families for DKKL1 Gene

Protein Domains for DKKL1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DKKL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK85

UniProtKB/Swiss-Prot:

DKKL1_HUMAN :
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
Domain:
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
genes like me logo Genes that share domains with DKKL1: view

No data available for Gene Families for DKKL1 Gene

Function for DKKL1 Gene

Gene Ontology (GO) - Molecular Function for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10570958
genes like me logo Genes that share ontologies with DKKL1: view
genes like me logo Genes that share phenotypes with DKKL1: view

Animal Models for DKKL1 Gene

MGI Knock Outs for DKKL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DKKL1

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DKKL1 Gene

Localization for DKKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKKL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DKKL1 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 10570958
genes like me logo Genes that share ontologies with DKKL1: view

Pathways & Interactions for DKKL1 Gene

SuperPathways for DKKL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0009653 anatomical structure morphogenesis TAS 10570958
GO:0045600 positive regulation of fat cell differentiation IEA --
genes like me logo Genes that share ontologies with DKKL1: view

No data available for Pathways by source and SIGNOR curated interactions for DKKL1 Gene

Transcripts for DKKL1 Gene

mRNA/cDNA for DKKL1 Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKKL1 Gene

Dickkopf-like 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKKL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - -

Relevant External Links for DKKL1 Gene

GeneLoc Exon Structure for
DKKL1
ECgene alternative splicing isoforms for
DKKL1

Expression for DKKL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DKKL1 Gene

mRNA differential expression in normal tissues according to GTEx for DKKL1 Gene

This gene is overexpressed in Testis (x51.1).

Protein differential expression in normal tissues from HIPED for DKKL1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DKKL1 Gene



Protein tissue co-expression partners for DKKL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DKKL1 Gene:

DKKL1

SOURCE GeneReport for Unigene cluster for DKKL1 Gene:

Hs.515855
genes like me logo Genes that share expression patterns with DKKL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DKKL1 Gene

Orthologs for DKKL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKKL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKKL1 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia DKKL1 34 35
  • 86.36 (n)
cow
(Bos Taurus)
Mammalia DKKL1 34 35
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Dkkl1 34
  • 75.19 (n)
mouse
(Mus musculus)
Mammalia Dkkl1 34 16 35
  • 75.08 (n)
Species where no ortholog for DKKL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKKL1 Gene

ENSEMBL:
Gene Tree for DKKL1 (if available)
TreeFam:
Gene Tree for DKKL1 (if available)

Paralogs for DKKL1 Gene

Pseudogenes.org Pseudogenes for DKKL1 Gene

genes like me logo Genes that share paralogs with DKKL1: view

No data available for Paralogs for DKKL1 Gene

Variants for DKKL1 Gene

Sequence variations from dbSNP and Humsavar for DKKL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10405465 -- 49,366,041(+) TCCTG(C/T)CTCAA intron-variant
rs1054770 -- 49,374,858(+) AGGGC(A/G)GCCAC intron-variant, reference, missense
rs10561364 -- 49,369,330(+) TTTTG(-/TTT)GTTTT intron-variant, nc-transcript-variant
rs10648468 -- 49,367,424(+) TTTTT(-/TT)GGAGA intron-variant
rs10700964 -- 49,366,724(+) TTTTT(-/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DKKL1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV gain+loss 18304495
esv3644622 CNV loss 21293372
dgv52n68 CNV loss 17160897

Variation tolerance for DKKL1 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.64; 98.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DKKL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DKKL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKKL1 Gene

Disorders for DKKL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DKKL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rectal neoplasm
  • neoplasm of rectum
- elite association - COSMIC cancer census association via MalaCards
Search DKKL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DKKL1

Genetic Association Database (GAD)
DKKL1
Human Genome Epidemiology (HuGE) Navigator
DKKL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DKKL1
genes like me logo Genes that share disorders with DKKL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DKKL1 Gene

Publications for DKKL1 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4 64
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  3. DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis. (PMID: 15892050) Kohn M.J. … DePamphilis M.L. (Mol. Reprod. Dev. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for DKKL1 Gene

Sources for DKKL1 Gene

Content
Loading form....