Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DKKL1 Gene

Aliases for DKKL1 Gene

  • Dickkopf Like Acrosomal Protein 1 2 3 5
  • Cancer/Testis Antigen 34 2 3 4
  • Dickkopf-Like 1 2 3
  • Protein Soggy-1 3 4
  • Soggy 2 3
  • SGY-1 3 4
  • CT34 3 4
  • SGY1 3 4
  • Testicular Secretory Protein Li 15 3
  • Dickkopf-Like Protein 1 3
  • Soggy-1 3
  • SGY 3

External Ids for DKKL1 Gene

Previous GeneCards Identifiers for DKKL1 Gene

  • GC19P054559
  • GC19P049871
  • GC19P046243

Summaries for DKKL1 Gene

Entrez Gene Summary for DKKL1 Gene

  • The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for DKKL1 Gene

DKKL1 (Dickkopf Like Acrosomal Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signal transducer activity.

UniProtKB/Swiss-Prot for DKKL1 Gene

  • Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility.

Additional gene information for DKKL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKKL1 Gene

Genomics for DKKL1 Gene

GeneHancer (GH) Regulatory Elements for DKKL1 Gene

Promoters and enhancers for DKKL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I049359 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 592 +1.8 1836 4.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A YY1 ZNF766 ZNF143 KLF13 DKKL1 TEAD2 CCDC155 LOC400710
GH19I049332 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.9 -25.1 -25136 5 HDAC1 HDGF YBX1 IRF4 EGR1 ZNF143 ETV6 ATF7 BCLAF1 IKZF2 CD37 DKKL1 CCDC155 ALDH16A1 BCL2L12 FLT3LG IRF3 SNRNP70 ENSG00000197813
GH19I049387 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 35.7 +27.7 27681 0.7 BCOR MEIS2 RB1 NFRKB YY1 E2F1 E2F8 POLR2A EGR1 ADNP CCDC155 LOC101928295 DKKL1
GH19I048958 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.9 -396.5 -396466 10.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 FTL ENSG00000267898 GC19P048966 GC19P048967 NUP62 PTOV1-AS2 IRF3 PRR12 SNORD35A SNORD35B
GH19I049390 Enhancer 1.2 Ensembl ENCODE 34.3 +30.8 30833 1.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZNF280A E2F8 ARID2 CCDC155 DKKL1 BCL2L12 POLD1 NUP62 MED25 GC19P049399 PIR32242
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DKKL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DKKL1 gene promoter:

Genomic Locations for DKKL1 Gene

Genomic Locations for DKKL1 Gene
chr19:49,360,495-49,375,119
(GRCh38/hg38)
Size:
14,625 bases
Orientation:
Plus strand
chr19:49,865,040-49,878,373
(GRCh37/hg19)

Genomic View for DKKL1 Gene

Genes around DKKL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKKL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKKL1 Gene

Proteins for DKKL1 Gene

  • Protein details for DKKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK85-DKKL1_HUMAN
    Recommended name:
    Dickkopf-like protein 1
    Protein Accession:
    Q9UK85

    Protein attributes for DKKL1 Gene

    Size:
    242 amino acids
    Molecular mass:
    27007 Da
    Quaternary structure:
    • Interacts with SLXL1; Co-localize in seminiferous tubules. Interacts with SLY.

neXtProt entry for DKKL1 Gene

Post-translational modifications for DKKL1 Gene

  • N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.
  • Glycosylation at Asn97 and posLast=112112

No data available for DME Specific Peptides for DKKL1 Gene

Domains & Families for DKKL1 Gene

Gene Families for DKKL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for DKKL1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DKKL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK85

UniProtKB/Swiss-Prot:

DKKL1_HUMAN :
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
Domain:
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
genes like me logo Genes that share domains with DKKL1: view

Function for DKKL1 Gene

Molecular function for DKKL1 Gene

UniProtKB/Swiss-Prot Function:
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
UniProtKB/Swiss-Prot Induction:
Abnormal expression in testes of patients with male infertility.

Phenotypes From GWAS Catalog for DKKL1 Gene

Gene Ontology (GO) - Molecular Function for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10570958
genes like me logo Genes that share ontologies with DKKL1: view
genes like me logo Genes that share phenotypes with DKKL1: view

Animal Models for DKKL1 Gene

MGI Knock Outs for DKKL1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DKKL1 Gene

Localization for DKKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKKL1 Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localized specifically to the crescent shaped acrosome at the apex of the sperm head. {ECO:0000250 UniProtKB:Q9QZL9}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DKKL1 gene
Compartment Confidence
extracellular 5
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 10570958
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with DKKL1: view

Pathways & Interactions for DKKL1 Gene

SuperPathways for DKKL1 Gene

No Data Available

Interacting Proteins for DKKL1 Gene

Gene Ontology (GO) - Biological Process for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007341 penetration of zona pellucida IEA,ISS --
GO:0009653 anatomical structure morphogenesis TAS 10570958
GO:0043065 positive regulation of apoptotic process IEA,ISS --
GO:0045600 positive regulation of fat cell differentiation IEA --
genes like me logo Genes that share ontologies with DKKL1: view

No data available for Pathways by source and SIGNOR curated interactions for DKKL1 Gene

Drugs & Compounds for DKKL1 Gene

No Compound Related Data Available

Transcripts for DKKL1 Gene

mRNA/cDNA for DKKL1 Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKKL1 Gene

Dickkopf-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKKL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - -

Relevant External Links for DKKL1 Gene

GeneLoc Exon Structure for
DKKL1
ECgene alternative splicing isoforms for
DKKL1

Expression for DKKL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DKKL1 Gene

mRNA differential expression in normal tissues according to GTEx for DKKL1 Gene

This gene is overexpressed in Testis (x51.1).

Protein differential expression in normal tissues from HIPED for DKKL1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DKKL1 Gene



Protein tissue co-expression partners for DKKL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DKKL1 Gene:

DKKL1

SOURCE GeneReport for Unigene cluster for DKKL1 Gene:

Hs.515855

mRNA Expression by UniProt/SwissProt for DKKL1 Gene:

Q9UK85-DKKL1_HUMAN
Tissue specificity: More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.
genes like me logo Genes that share expression patterns with DKKL1: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DKKL1 Gene

Orthologs for DKKL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKKL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKKL1 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia DKKL1 33 34
  • 86.36 (n)
cow
(Bos Taurus)
Mammalia DKKL1 33 34
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Dkkl1 33
  • 75.19 (n)
mouse
(Mus musculus)
Mammalia Dkkl1 33 16 34
  • 75.08 (n)
Species where no ortholog for DKKL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKKL1 Gene

ENSEMBL:
Gene Tree for DKKL1 (if available)
TreeFam:
Gene Tree for DKKL1 (if available)

Paralogs for DKKL1 Gene

Pseudogenes.org Pseudogenes for DKKL1 Gene

genes like me logo Genes that share paralogs with DKKL1: view

No data available for Paralogs for DKKL1 Gene

Variants for DKKL1 Gene

Sequence variations from dbSNP and Humsavar for DKKL1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000005557 -- 49,371,375(+) T/G intron_variant
rs1000176810 -- 49,371,707(+) T/A intron_variant
rs1000268053 -- 49,365,334(+) G/A intron_variant
rs1000498711 -- 49,359,692(+) G/A upstream_transcript_variant
rs1000551422 -- 49,375,355(+) T/A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DKKL1 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
esv3644622 CNV loss 21293372
nsv9739 CNV gain+loss 18304495

Variation tolerance for DKKL1 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.64; 98.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DKKL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DKKL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKKL1 Gene

Disorders for DKKL1 Gene

Additional Disease Information for DKKL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DKKL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DKKL1 Gene

Publications for DKKL1 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik VE … McCarthy SA (Gene 1999) 2 3 4 58
  2. Developmental expression and function of DKKL1/Dkkl1 in humans and mice. (PMID: 22817830) Yan Q … Cai Z (Reproductive biology and endocrinology : RB&E 2012) 3 4 58
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  4. DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis. (PMID: 15892050) Kohn MJ … DePamphilis ML (Molecular reproduction and development 2005) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DKKL1 Gene

Sources for DKKL1 Gene

Content
Loading form....