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Aliases for DKKL1 Gene

Aliases for DKKL1 Gene

  • Dickkopf-Like 1 2 3
  • Cancer/Testis Antigen 34 2 3 4
  • SGY1 3 4 6
  • Protein Soggy-1 3 4
  • Soggy 2 3
  • SGY-1 3 4
  • CT34 3 4
  • SGY 3 6
  • Dickkopf-Like Protein 1 3
  • Dickkopf-Like 1 (Soggy) 2
  • Soggy-1 3

External Ids for DKKL1 Gene

Previous GeneCards Identifiers for DKKL1 Gene

  • GC19P054559
  • GC19P049871
  • GC19P046243

Summaries for DKKL1 Gene

Entrez Gene Summary for DKKL1 Gene

  • The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for DKKL1 Gene

DKKL1 (Dickkopf-Like 1) is a Protein Coding gene. Among its related pathways are Non-Canonical Wnt Pathway and Non-Canonical Wnt Pathway. GO annotations related to this gene include signal transducer activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKKL1 Gene

Genomics for DKKL1 Gene

Regulatory Elements for DKKL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DKKL1 Gene

Start:
49,360,503 bp from pter
End:
49,375,116 bp from pter
Size:
14,614 bases
Orientation:
Plus strand

Genomic View for DKKL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DKKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKKL1 Gene

Proteins for DKKL1 Gene

  • Protein details for DKKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK85-DKKL1_HUMAN
    Recommended name:
    Dickkopf-like protein 1
    Protein Accession:
    Q9UK85
    Secondary Accessions:

    Protein attributes for DKKL1 Gene

    Size:
    242 amino acids
    Molecular mass:
    27007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DKKL1 Gene

Proteomics data for DKKL1 Gene at MOPED

Post-translational modifications for DKKL1 Gene

Antibody Products

  • R&D Systems Antibodies for DKKL1 (Soggy-1/DkkL1)

No data available for DME Specific Peptides for DKKL1 Gene

Domains for DKKL1 Gene

Protein Domains for DKKL1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DKKL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK85

UniProtKB/Swiss-Prot:

DKKL1_HUMAN :
  • Q9UK85
Domain:
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3
genes like me logo Genes that share domains with DKKL1: view

No data available for Gene Families for DKKL1 Gene

Function for DKKL1 Gene

Gene Ontology (GO) - Molecular Function for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10570958
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DKKL1: view
genes like me logo Genes that share phenotypes with DKKL1: view

Animal Models for DKKL1 Gene

MGI Knock Outs for DKKL1:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DKKL1 Gene

Localization for DKKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKKL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DKKL1 Gene COMPARTMENTS Subcellular localization image for DKKL1 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 10570958
genes like me logo Genes that share ontologies with DKKL1: view

Pathways for DKKL1 Gene

genes like me logo Genes that share pathways with DKKL1: view

Pathways by source for DKKL1 Gene

2 Sino Biological pathways for DKKL1 Gene

Gene Ontology (GO) - Biological Process for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007165 signal transduction TAS 10570958
GO:0009653 anatomical structure morphogenesis TAS 10570958
GO:0045600 positive regulation of fat cell differentiation IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with DKKL1: view

Transcripts for DKKL1 Gene

mRNA/cDNA for DKKL1 Gene

(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(11) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKKL1 Gene

Dickkopf-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DKKL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKKL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - -

Relevant External Links for DKKL1 Gene

GeneLoc Exon Structure for
DKKL1
ECgene alternative splicing isoforms for
DKKL1

Expression for DKKL1 Gene

mRNA expression in normal human tissues for DKKL1 Gene

mRNA differential expression in normal tissues according to GTEx for DKKL1 Gene

This gene is overexpressed in Testis (51.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DKKL1 Gene

SOURCE GeneReport for Unigene cluster for DKKL1 Gene Hs.515855

genes like me logo Genes that share expressions with DKKL1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DKKL1 Gene

Orthologs for DKKL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKKL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKKL1 35
  • 99.45 (n)
  • 98.76 (a)
DKKL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DKKL1 35
  • 83.91 (n)
  • 76.09 (a)
DKKL1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DKKL1 35
  • 86.36 (n)
  • 80 (a)
DKKL1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dkkl1 35
  • 75.08 (n)
  • 65.42 (a)
Dkkl1 16
Dkkl1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dkkl1 35
  • 75.19 (n)
  • 66.51 (a)
Species with no ortholog for DKKL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKKL1 Gene

ENSEMBL:
Gene Tree for DKKL1 (if available)
TreeFam:
Gene Tree for DKKL1 (if available)

Paralogs for DKKL1 Gene

Pseudogenes.org Pseudogenes for DKKL1 Gene

genes like me logo Genes that share paralogs with DKKL1: view

No data available for Paralogs for DKKL1 Gene

Variants for DKKL1 Gene

Sequence variations from dbSNP and Humsavar for DKKL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs919364 - 49,364,656(+) CCTCC(A/G)CTGCA missense, reference, utr-variant-5-prime
rs2303757 - 49,364,642(+) TACCC(G/T)GGTGA missense, reference, utr-variant-5-prime
rs2303758 -- 49,365,702(+) ATCCC(G/T)CCATC intron-variant
rs2303759 - 49,365,794(+) ACAGA(G/T)GACCG intron-variant, missense, reference
rs2335533 -- 49,366,610(+) TTTCA(A/G)TCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DKKL1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
nsv912261 CNV Loss 21882294

Relevant External Links for DKKL1 Gene

HapMap Linkage Disequilibrium report
DKKL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKKL1 Gene

Disorders for DKKL1 Gene

Relevant External Links for DKKL1

Genetic Association Database (GAD)
DKKL1
Human Genome Epidemiology (HuGE) Navigator
DKKL1
genes like me logo Genes that share disorders with DKKL1: view

No data available for UniProtKB/Swiss-Prot for DKKL1 Gene

Publications for DKKL1 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 48
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for DKKL1 Gene

Sources for DKKL1 Gene

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