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DKKL1 Gene

protein-coding   GIFtS: 51
GCID: GC19P049871

Dickkopf-Like 1

(Previous name: dickkopf-like 1 (soggy))
  Search for DKKL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dickkopf-Like 11 2     SGY-12 3
Cancer/Testis Antigen 341 2 3     SGY2 5
SGY12 3 5     Dickkopf-Like 1 (Soggy)1
soggy1 2     Dickkopf-Like Protein 12
Protein Soggy-12 3     soggy-12
CT342 3     

External Ids:    HGNC: 165281   Entrez Gene: 271202   Ensembl: ENSG000001049017   OMIM: 6054185   UniProtKB: Q9UK853   

Export aliases for DKKL1 gene to outside databases

Previous GC identifers: GC19P054559 GC19P046243


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DKKL1 Gene:
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two
conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the
dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found
for this gene. (provided by RefSeq, Oct 2010)

GeneCards Summary for DKKL1 Gene:
DKKL1 (dickkopf-like 1) is a protein-coding gene. GO annotations related to this gene include signal transducer activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DKKL1 gene promoter:
         TBP   HSF1 (long)   MyoD   MZF-1   CREB   FAC1   deltaCREB   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDKKL1 promoter sequence
   Search Chromatin IP Primers for DKKL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DKKL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

DKKL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKKL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049871:  view genomic region     (about GC identifiers)

Start:
49,865,040 bp from pter      End:
49,878,373 bp from pter
Size:
13,334 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DKKL1_HUMAN, Q9UK85 (See protein sequence)
Recommended Name: Dickkopf-like protein 1 precursor  
Size: 242 amino acids; 27007 Da

Explore the universe of human proteins at neXtProt for DKKL1: NX_Q9UK85

Explore proteomics data for DKKL1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn97, Asn112
  • Modification sites at PhosphoSitePlus

  • See DKKL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001184230.1  NP_001184231.1  NP_055234.1  

    ENSEMBL proteins: 
     ENSP00000469865   ENSP00000472866   ENSP00000221498   ENSP00000470676   ENSP00000472056  
     ENSP00000471812  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9UK85

    UniProtKB/Swiss-Prot: DKKL1_HUMAN, Q9UK85
    Domain: Contains a N-terminal domain similar to that of the N-terminal section of DKK3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS10570958
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DKKL1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dkkl1):
     endocrine/exocrine gland  reproductive system  skeleton 

    Find genes that share phenotypes with DKKL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dkkl1tm1.1Mldp for DKKL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DKKL1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DKKL1_HUMAN, Q9UK85: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS10570958

    Find genes that share ontologies with DKKL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DKKL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53


    2 Sino Biological Pathways for DKKL1
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DKKL1
    Interactions:

        Search GeneGlobe Interaction Network for DKKL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for DKKL1 (Q9UK853 ENSP000002214984) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    SCFD1Q8WVM83, ENSP000003907834I2D: score=1 STRING: ENSP00000390783
    C11orf71ENSP000003255084STRING: ENSP00000325508
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10570958
    GO:0009653anatomical structure morphogenesis TAS10570958
    GO:0045600positive regulation of fat cell differentiation IEA--

    Find genes that share ontologies with DKKL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DKKL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DKKL1 gene (3 alternative transcripts): 
    NM_001197301.1  NM_001197302.1  NM_014419.3  

    Unigene Cluster for DKKL1:

    Dickkopf-like 1
    Hs.515855  [show with all ESTs]
    Unigene Representative Sequence: AY358922
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594268 ENST00000597873 ENST00000221498(uc021uxk.1 uc002pnk.3 uc021uxl.1)
    ENST00000596402 ENST00000597546 ENST00000598682
    miRNA
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    hsa-miR-587
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      QuantiFast Probe-based Assays in human, mouse, rat DKKL1

    Additional mRNA sequence: 

    AF177398.1 AY358922.1 BC030581.2 

    5 DOTS entries:

    DT.208577  DT.100746257  DT.100034189  DT.95366122  DT.95366125 

    4 AceView cDNA sequences:

    NM_014419 AY358922 AF177398 BC030581 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DKKL1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
    SP1:        -     -     -     -                       -                           
    SP2:                          -                       -                           
    SP3:                                                  -                           
    SP4:                                                                              
    SP5:                                            -     -                           


    ECgene alternative splicing isoforms for DKKL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DKKL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCCGGG
    DKKL1 Expression
    About this image


    DKKL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
             Long-time differentiated EBs
             testis ; cells in seminiferous ducts   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             ES-J1
    DKKL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DKKL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515855
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for DKKL1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dkkl11 , 5 dickkopf-like 11, 5 75.08(n)1
    65.42(a)1
      7 (29.19 cM)5
    507221  NM_015789.31  NP_056604.21 
     452075255 


    ENSEMBL Gene Tree for DKKL1 (if available)
    TreeFam Gene Tree for DKKL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DKKL1 gene

    Find genes that share paralogs with DKKL1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DKKL1
    PGOHUM00000247640


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DKKL1 (see all 332)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000284661,2
    --46241613(+) CGGGG-/AGGGGG 2 -- us2k10--------
    rs1145201841,2
    C--46241620(+) GGGGGA/GACAGG 2 -- us2k10--------
    rs2010878241,2
    --46241620(+) GGGGG-/AACAGG 2 -- us2k10--------
    rs1388812241,2
    C--46241651(+) GGCCC-/AGAG  
            
    AGAGA
    2 -- us2k10--------
    rs1180005881,2
    C--46241684(+) GAGGGG/TGACAG 2 -- us2k10--------
    rs1502918201,2
    --46241694(+) GAGACA/CCAGAG 2 -- us2k10--------
    rs2020608361,2
    --46241800(+) GGGGA-/CCACAG 2 -- us2k10--------
    rs1113438161,2
    F--46241803(+) GGACAC/GAGACT 2 -- us2k12Minor allele frequency- G:0.12CSA WA 120
    rs1154095001,2
    F--46241806(+) CACAGA/GCTCAG 2 -- us2k11Minor allele frequency- G:0.10WA 118
    rs1464123181,2
    --46241808(+) CAGACC/TCAGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DKKL1 (49865040 - 49878373 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DKKL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv52n68CNV Loss17160897
    nsv912261CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605418    OMIM disorders: --


    Find genes that share disorders with DKKL1           About GenesLikeMe

    Genetic Association Database (GAD): DKKL1
    Human Genome Epidemiology (HuGE) Navigator: DKKL1 (1 document)

    Export disorders for DKKL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DKKL1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with DKKL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3 Krupnik V.E.... McCarthy S.A. (Gene 1999)
    2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes. (PubMed id 24190897)1 Hsieh J.C....Haussler M.R. (J. Endocrinol. 2014)
    6. Protein interactions of the transcription factor Hoxa1. (PubMed id 23088713)1 Lambert B....Rezsohazy R. (BMC Dev. Biol. 2012)
    7. Developmental expression and function of DKKL1/Dkkl1 in humans and mice. (PubMed id 22817830)1 Yan Q....Cai Z. (amp 2012)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. (PubMed id 19176879)1 Reynard L.N....Burgoyne P.S. (Biol. Reprod. 2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27120 HGNC: 16528 AceView: DKKL1 Ensembl:ENSG00000104901 euGenes: HUgn27120
    ECgene: DKKL1 H-InvDB: DKKL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DKKL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DKKL1 gene:
    Search GeneIP for patents involving DKKL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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