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Aliases for DKKL1 Gene

Aliases for DKKL1 Gene

  • Dickkopf Like Acrosomal Protein 1 2 3
  • Cancer/Testis Antigen 34 2 3 4
  • Dickkopf-Like 1 2 3 5
  • Protein Soggy-1 3 4
  • Soggy 2 3
  • SGY-1 3 4
  • CT34 3 4
  • SGY1 3 4
  • Testicular Secretory Protein Li 15 3
  • Soggy-1 3
  • SGY 3

External Ids for DKKL1 Gene

Previous GeneCards Identifiers for DKKL1 Gene

  • GC19P054559
  • GC19P049871
  • GC19P046243

Summaries for DKKL1 Gene

Entrez Gene Summary for DKKL1 Gene

  • The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for DKKL1 Gene

DKKL1 (Dickkopf Like Acrosomal Protein 1) is a Protein Coding gene. Among its related pathways are Non-Canonical Wnt Pathway. GO annotations related to this gene include signal transducer activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKKL1 Gene

Genomics for DKKL1 Gene

Regulatory Elements for DKKL1 Gene

Enhancers for DKKL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DKKL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DKKL1 Gene

49,360,495 bp from pter
49,375,119 bp from pter
14,625 bases
Plus strand

Genomic View for DKKL1 Gene

Genes around DKKL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKKL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKKL1 Gene

Proteins for DKKL1 Gene

  • Protein details for DKKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dickkopf-like protein 1
    Protein Accession:

    Protein attributes for DKKL1 Gene

    242 amino acids
    Molecular mass:
    27007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DKKL1 Gene

Proteomics data for DKKL1 Gene at MOPED

Post-translational modifications for DKKL1 Gene

Antibody Products

  • R&D Systems Antibodies for DKKL1 (Soggy-1/DkkL1)

No data available for DME Specific Peptides for DKKL1 Gene

Domains & Families for DKKL1 Gene

Protein Domains for DKKL1 Gene


Suggested Antigen Peptide Sequences for DKKL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
genes like me logo Genes that share domains with DKKL1: view

No data available for Gene Families for DKKL1 Gene

Function for DKKL1 Gene

Gene Ontology (GO) - Molecular Function for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10570958
genes like me logo Genes that share ontologies with DKKL1: view
genes like me logo Genes that share phenotypes with DKKL1: view

Animal Models for DKKL1 Gene

MGI Knock Outs for DKKL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DKKL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DKKL1 Gene

Localization for DKKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKKL1 Gene


Subcellular locations from

Jensen Localization Image for DKKL1 Gene COMPARTMENTS Subcellular localization image for DKKL1 gene
Compartment Confidence
extracellular 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for DKKL1 Gene

Pathways & Interactions for DKKL1 Gene

genes like me logo Genes that share pathways with DKKL1: view

Pathways by source for DKKL1 Gene

2 Sino Biological pathways for DKKL1 Gene

Gene Ontology (GO) - Biological Process for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009653 anatomical structure morphogenesis TAS 10570958
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with DKKL1: view

No data available for SIGNOR curated interactions for DKKL1 Gene

Drugs & Compounds for DKKL1 Gene

No Compound Related Data Available

Transcripts for DKKL1 Gene

mRNA/cDNA for DKKL1 Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKKL1 Gene

Dickkopf-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DKKL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - -
SP3: -
SP5: - -

Relevant External Links for DKKL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DKKL1 Gene

mRNA expression in normal human tissues for DKKL1 Gene

mRNA differential expression in normal tissues according to GTEx for DKKL1 Gene

This gene is overexpressed in Testis (x51.1).

Protein differential expression in normal tissues from HIPED for DKKL1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DKKL1 Gene

SOURCE GeneReport for Unigene cluster for DKKL1 Gene Hs.515855

genes like me logo Genes that share expression patterns with DKKL1: view

Protein tissue co-expression partners for DKKL1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DKKL1 Gene

Orthologs for DKKL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKKL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DKKL1 35
  • 83.91 (n)
  • 76.09 (a)
DKKL1 36
  • 76 (a)
(Canis familiaris)
Mammalia DKKL1 35
  • 86.36 (n)
  • 80 (a)
DKKL1 36
  • 79 (a)
(Mus musculus)
Mammalia Dkkl1 35
  • 75.08 (n)
  • 65.42 (a)
Dkkl1 16
Dkkl1 36
  • 63 (a)
(Pan troglodytes)
Mammalia DKKL1 35
  • 99.45 (n)
  • 98.76 (a)
DKKL1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dkkl1 35
  • 75.19 (n)
  • 66.51 (a)
Species with no ortholog for DKKL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKKL1 Gene

Gene Tree for DKKL1 (if available)
Gene Tree for DKKL1 (if available)

Paralogs for DKKL1 Gene Pseudogenes for DKKL1 Gene

genes like me logo Genes that share paralogs with DKKL1: view

No data available for Paralogs for DKKL1 Gene

Variants for DKKL1 Gene

Sequence variations from dbSNP and Humsavar for DKKL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2303759 - 49,365,794(+) ACAGA(G/T)GACCG intron-variant, reference, missense
VAR_021968 -
rs919364 - 49,364,656(+) CCTCC(A/G)CTGCA reference, missense, utr-variant-5-prime
rs2303757 - 49,364,642(+) TACCC(C/G/T)GGTGA reference, missense, utr-variant-5-prime
rs35693137 - 49,365,635(+) GCCAC(A/C)TCCAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DKKL1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
nsv912261 CNV Loss 21882294

Variation tolerance for DKKL1 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.64; 98.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DKKL1 Gene

Disorders for DKKL1 Gene

Relevant External Links for DKKL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DKKL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DKKL1 Gene

Publications for DKKL1 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4 67
  2. DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis. (PMID: 15892050) Kohn M.J. … DePamphilis M.L. (Mol. Reprod. Dev. 2005) 2 3
  3. Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes. (PMID: 24190897) Hsieh J.C. … Haussler M.R. (J. Endocrinol. 2014) 3
  4. Dickkopf-3 alters the morphological response to retinoic acid during neuronal differentiation of human embryonal carcinoma cells. (PMID: 24909558) Alfonso R.J. … Kypta R. (Dev Neurobiol 2014) 3
  5. Developmental expression and function of DKKL1/Dkkl1 in humans and mice. (PMID: 22817830) Yan Q. … Cai Z. (Reprod. Biol. Endocrinol. 2012) 3

Products for DKKL1 Gene

Sources for DKKL1 Gene