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Aliases for DKKL1 Gene

Aliases for DKKL1 Gene

  • Dickkopf Like Acrosomal Protein 1 2 3 5
  • Cancer/Testis Antigen 34 2 3 4
  • Dickkopf-Like 1 2 3
  • Protein Soggy-1 3 4
  • Soggy 2 3
  • SGY-1 3 4
  • CT34 3 4
  • SGY1 3 4
  • Testicular Secretory Protein Li 15 3
  • Dickkopf-Like Protein 1 3
  • Soggy-1 3
  • SGY 3

External Ids for DKKL1 Gene

Previous GeneCards Identifiers for DKKL1 Gene

  • GC19P054559
  • GC19P049871
  • GC19P046243

Summaries for DKKL1 Gene

Entrez Gene Summary for DKKL1 Gene

  • The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for DKKL1 Gene

DKKL1 (Dickkopf Like Acrosomal Protein 1) is a Protein Coding gene. Diseases associated with DKKL1 include Rectal Neoplasm. GO annotations related to this gene include signal transducer activity.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKKL1 Gene

Genomics for DKKL1 Gene

Regulatory Elements for DKKL1 Gene

Enhancers for DKKL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049332 1.6 FANTOM5 ENCODE dbSUPER 39.9 -25.1 -25136 5.0 HDGF AGO1 WRNIP1 YBX1 ELK1 ZNF143 NCOA1 REST TBX21 SMARCB1 DKKL1 CCDC155 CD37 ALDH16A1 BCL2L12 FLT3LG IRF3 SNRNP70 ENSG00000197813
GH19G049359 1.4 ENCODE dbSUPER 41.9 +1.8 1837 4.8 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 DKKL1 CCDC155 NUP62 GRWD1 AKT1S1 SNORD35A PRR12 KDELR1 PIH1D1 PTOV1-AS2
GH19G049390 1.2 Ensembl ENCODE 34.3 +30.8 30834 1.7 HDGF PKNOX1 ARNT ARID4B YBX1 ZNF2 ZNF143 DEK SP3 JUNB CCDC155 DKKL1 BCL2L12 GC19P049399 PIR32242
GH19G048780 1.6 Ensembl ENCODE dbSUPER 22.3 -578.8 -578785 2.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B ZNF766 ZNF143 FOS PRR12 PIH1D1 GRWD1 SNORD35A DKKL1 KDELR1 SNORD35B CYTH2 ENSG00000268093 RPS11
GH19G048413 1.3 Ensembl ENCODE 24.8 -945.4 -945432 2.7 HDGF ATF1 PKNOX1 CREB3L1 ARNT ZFP64 GLI4 YY1 TCF12 ZNF121 DKKL1 EHD2 GRWD1 BICRA ENSG00000268746 RPL18 KDELR1 NOP53-AS1 RASIP1 CYTH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DKKL1 on UCSC Golden Path with GeneCards custom track

Promoters for DKKL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110881 1505 2001 HDGF ARID4B SIN3A ZNF48 YY1 GLIS2 SP3 SP5 YY2 NFYC

Genomic Location for DKKL1 Gene

Chromosome:
19
Start:
49,360,495 bp from pter
End:
49,375,119 bp from pter
Size:
14,625 bases
Orientation:
Plus strand

Genomic View for DKKL1 Gene

Genes around DKKL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKKL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKKL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKKL1 Gene

Proteins for DKKL1 Gene

  • Protein details for DKKL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK85-DKKL1_HUMAN
    Recommended name:
    Dickkopf-like protein 1
    Protein Accession:
    Q9UK85

    Protein attributes for DKKL1 Gene

    Size:
    242 amino acids
    Molecular mass:
    27007 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DKKL1 Gene

Post-translational modifications for DKKL1 Gene

No data available for DME Specific Peptides for DKKL1 Gene

Domains & Families for DKKL1 Gene

Protein Domains for DKKL1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DKKL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK85

UniProtKB/Swiss-Prot:

DKKL1_HUMAN :
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
Domain:
  • Contains a N-terminal domain similar to that of the N-terminal section of DKK3.
genes like me logo Genes that share domains with DKKL1: view

No data available for Gene Families for DKKL1 Gene

Function for DKKL1 Gene

Gene Ontology (GO) - Molecular Function for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10570958
genes like me logo Genes that share ontologies with DKKL1: view
genes like me logo Genes that share phenotypes with DKKL1: view

Animal Models for DKKL1 Gene

MGI Knock Outs for DKKL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DKKL1

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DKKL1 Gene

Localization for DKKL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKKL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DKKL1 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 10570958
genes like me logo Genes that share ontologies with DKKL1: view

Pathways & Interactions for DKKL1 Gene

SuperPathways for DKKL1 Gene

No Data Available

Interacting Proteins for DKKL1 Gene

Gene Ontology (GO) - Biological Process for DKKL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0009653 anatomical structure morphogenesis TAS 10570958
GO:0045600 positive regulation of fat cell differentiation IEA --
genes like me logo Genes that share ontologies with DKKL1: view

No data available for Pathways by source and SIGNOR curated interactions for DKKL1 Gene

Drugs & Compounds for DKKL1 Gene

No Compound Related Data Available

Transcripts for DKKL1 Gene

mRNA/cDNA for DKKL1 Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKKL1 Gene

Dickkopf-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKKL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - -

Relevant External Links for DKKL1 Gene

GeneLoc Exon Structure for
DKKL1
ECgene alternative splicing isoforms for
DKKL1

Expression for DKKL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DKKL1 Gene

mRNA differential expression in normal tissues according to GTEx for DKKL1 Gene

This gene is overexpressed in Testis (x51.1).

Protein differential expression in normal tissues from HIPED for DKKL1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DKKL1 Gene



Protein tissue co-expression partners for DKKL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DKKL1 Gene:

DKKL1

SOURCE GeneReport for Unigene cluster for DKKL1 Gene:

Hs.515855
genes like me logo Genes that share expression patterns with DKKL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DKKL1 Gene

Orthologs for DKKL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKKL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKKL1 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia DKKL1 34 35
  • 86.36 (n)
cow
(Bos Taurus)
Mammalia DKKL1 34 35
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Dkkl1 34
  • 75.19 (n)
mouse
(Mus musculus)
Mammalia Dkkl1 34 16 35
  • 75.08 (n)
Species where no ortholog for DKKL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKKL1 Gene

ENSEMBL:
Gene Tree for DKKL1 (if available)
TreeFam:
Gene Tree for DKKL1 (if available)

Paralogs for DKKL1 Gene

Pseudogenes.org Pseudogenes for DKKL1 Gene

genes like me logo Genes that share paralogs with DKKL1: view

No data available for Paralogs for DKKL1 Gene

Variants for DKKL1 Gene

Sequence variations from dbSNP and Humsavar for DKKL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000005557 -- 49,371,375(+) ATTTT(G/T)TAAAA intron-variant
rs1000176810 -- 49,371,707(+) GTGGT(A/T)TGCTG intron-variant
rs1000268053 -- 49,365,334(+) AGAGA(A/G)AATTC intron-variant
rs1000498711 -- 49,359,692(+) TGTGC(A/G)ACCAT intron-variant, upstream-variant-2KB
rs1000551422 -- 49,375,355(+) TTGCT(A/T)TTTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DKKL1 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
esv3644622 CNV loss 21293372
nsv9739 CNV gain+loss 18304495

Variation tolerance for DKKL1 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.64; 98.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DKKL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DKKL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKKL1 Gene

Disorders for DKKL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DKKL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rectal neoplasm
  • neoplasm of rectum
- elite association - COSMIC cancer census association via MalaCards
Search DKKL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DKKL1

Genetic Association Database (GAD)
DKKL1
Human Genome Epidemiology (HuGE) Navigator
DKKL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DKKL1
genes like me logo Genes that share disorders with DKKL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DKKL1 Gene

Publications for DKKL1 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4 64
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  3. DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis. (PMID: 15892050) Kohn M.J. … DePamphilis M.L. (Mol. Reprod. Dev. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for DKKL1 Gene

Sources for DKKL1 Gene

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