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Aliases for DKK4 Gene

Aliases for DKK4 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 4 2 3 5
  • Dickkopf-4 3 4
  • HDkk-4 3 4
  • DKK-4 3 4
  • Dickkopf (Xenopus Laevis) Homolog 4 2
  • Dickkopf Homolog 4 (Xenopus Laevis) 2

External Ids for DKK4 Gene

Previous GeneCards Identifiers for DKK4 Gene

  • GC08P041716
  • GC08M042257
  • GC08M041972
  • GC08M042248
  • GC08M040754

Summaries for DKK4 Gene

Entrez Gene Summary for DKK4 Gene

  • This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK4 Gene

DKK4 (Dickkopf WNT Signaling Pathway Inhibitor 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. An important paralog of this gene is DKK1.

UniProtKB/Swiss-Prot for DKK4 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK4 Gene

Genomics for DKK4 Gene

Regulatory Elements for DKK4 Gene

Genomic Location for DKK4 Gene

Chromosome:
8
Start:
42,373,194 bp from pter
End:
42,391,754 bp from pter
Size:
18,561 bases
Orientation:
Minus strand

Genomic View for DKK4 Gene

Genes around DKK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK4 Gene

Proteins for DKK4 Gene

  • Protein details for DKK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBT3-DKK4_HUMAN
    Recommended name:
    Dickkopf-related protein 4
    Protein Accession:
    Q9UBT3
    Secondary Accessions:
    • Q3KNX0
    • Q9Y4C3

    Protein attributes for DKK4 Gene

    Size:
    224 amino acids
    Molecular mass:
    24876 Da
    Quaternary structure:
    • Interacts with LRP5 and LRP6.

neXtProt entry for DKK4 Gene

Proteomics data for DKK4 Gene at MOPED

Post-translational modifications for DKK4 Gene

Other Protein References for DKK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DKK4 Gene

Domains & Families for DKK4 Gene

Protein Domains for DKK4 Gene

Suggested Antigen Peptide Sequences for DKK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBT3

UniProtKB/Swiss-Prot:

DKK4_HUMAN :
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Belongs to the dickkopf family.
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Family:
  • Belongs to the dickkopf family.
genes like me logo Genes that share domains with DKK4: view

No data available for Gene Families for DKK4 Gene

Function for DKK4 Gene

Molecular function for DKK4 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

LifeMap Function Summary for DKK4 Gene

During embryonic development, DKK4 as signaling molecule is secreted from the following cells

Phenotypes for DKK4 Gene

MGI mutant phenotypes for DKK4:
inferred from 1 alleles
GenomeRNAi human phenotypes for DKK4:
genes like me logo Genes that share phenotypes with DKK4: view

Animal Model Products

miRNA for DKK4 Gene

miRTarBase miRNAs that target DKK4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DKK4 Gene

Localization for DKK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DKK4 Gene COMPARTMENTS Subcellular localization image for DKK4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DKK4: view

Pathways & Interactions for DKK4 Gene

genes like me logo Genes that share pathways with DKK4: view

Pathways by source for DKK4 Gene

Interacting Proteins for DKK4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000220812%0d%0a9606.ENSP00000265165%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000261349%0d%0a
Selected Interacting proteins: ENSP00000220812 for DKK4 Gene via STRING

Gene Ontology (GO) - Biological Process for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0061170 negative regulation of hair follicle placode formation IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway NAS 24431302
genes like me logo Genes that share ontologies with DKK4: view

No data available for SIGNOR curated interactions for DKK4 Gene

Drugs & Compounds for DKK4 Gene

(1) Drugs for DKK4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KY 02111 Pharma WNT signaling inhibitor 0

(1) ApexBio Compounds for DKK4 Gene

Compound Action Cas Number
KY 02111 WNT signaling inhibitor 1118807-13-8
genes like me logo Genes that share compounds with DKK4: view

Transcripts for DKK4 Gene

mRNA/cDNA for DKK4 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKK4 Gene

Dickkopf homolog 4 (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DKK4 Gene

No ASD Table

Relevant External Links for DKK4 Gene

GeneLoc Exon Structure for
DKK4
ECgene alternative splicing isoforms for
DKK4

Expression for DKK4 Gene

mRNA expression in normal human tissues for DKK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DKK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.8), Esophagus - Mucosa (x5.9), Brain - Cerebellum (x5.6), and Vagina (x5.5).

SOURCE GeneReport for Unigene cluster for DKK4 Gene Hs.159311

mRNA Expression by UniProt/SwissProt for DKK4 Gene

Q9UBT3-DKK4_HUMAN
Tissue specificity: Expressed in cerebellum, T-cells, esophagus and lung.
genes like me logo Genes that share expression patterns with DKK4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DKK4 Gene

Orthologs for DKK4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKK4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DKK4 35
  • 84.25 (n)
  • 80.73 (a)
DKK4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dkk4 35
  • 75.72 (n)
  • 76.02 (a)
Dkk4 16
Dkk4 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DKK4 35
  • 99.55 (n)
  • 99.11 (a)
DKK4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dkk4 35
  • 75.11 (n)
  • 76.47 (a)
cow
(Bos Taurus)
Mammalia DKK4 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DKK4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
Species with no ortholog for DKK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKK4 Gene

ENSEMBL:
Gene Tree for DKK4 (if available)
TreeFam:
Gene Tree for DKK4 (if available)

Paralogs for DKK4 Gene

Paralogs for DKK4 Gene

(2) SIMAP similar genes for DKK4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DKK4: view

Variants for DKK4 Gene

Sequence variations from dbSNP and Humsavar for DKK4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2073663 -- 42,374,642(-) AGCAT(A/G)TGCTG intron-variant
rs2073664 -- 42,374,268(-) CCAGT(C/T)CTTTT reference, synonymous-codon
rs2073665 -- 42,374,971(-) TAGTG(C/T)GTCTG intron-variant
rs3763511 -- 42,378,340(-) AGATT(C/T)ATGTC intron-variant, upstream-variant-2KB
rs10101492 -- 42,379,285(+) GGTGT(G/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DKK4 Gene

Variant ID Type Subtype PubMed ID
nsv831301 CNV Loss 17160897

Variation tolerance for DKK4 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DKK4 Gene

HapMap Linkage Disequilibrium report
DKK4
Human Gene Mutation Database (HGMD)
DKK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKK4 Gene

Disorders for DKK4 Gene

Relevant External Links for DKK4

Genetic Association Database (GAD)
DKK4
Human Genome Epidemiology (HuGE) Navigator
DKK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DKK4

No disorders were found for DKK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DKK4 Gene

Publications for DKK4 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4 23 67
  2. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H. … Dahiya R. (Cancer 2009) 3 23
  3. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. (PMID: 18408752) PendA!s-Franco N. … GonzA!lez-Sancho J.M. (Oncogene 2008) 3 23
  4. Assignment of the human dickkopf (Xenopus) homolog 4 (DKK4) to chromosome 8p11.2-->p11.1 by fluorescence in situ hybridization. (PMID: 11701963) Yoshida S. … Tate G. (Cytogenet. Cell Genet. 2001) 2 3
  5. [MODERN METHODS OF PROGNOSTICATION OF THE RECURRENCES OCCURRENCE AFTER SURGICAL TREATMENT OF THE MAMMARY GLAND BENIGN TUMORS]. (PMID: 26419038) Usenko O.Y. … Romak R.P. (Klin Khir 2015) 3

Products for DKK4 Gene

Sources for DKK4 Gene

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