Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DKK4 Gene

protein-coding   GIFtS: 56
GCID: GC08M042248

Dickkopf WNT Signaling Pathway Inhibitor 4

(Previous names: dickkopf (Xenopus laevis) homolog 4, dickkopf homolog 4...)
  See DKK4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dickkopf WNT Signaling Pathway Inhibitor 41 2     dickkopf-42
hDkk-42 3     Dickkopf-Related Protein 42
Dickkopf (Xenopus Laevis) Homolog 41     Dickkopf-43
Dickkopf Homolog 4 (Xenopus Laevis)1     Dkk-43
DKK-42     

External Ids:    HGNC: 28941   Entrez Gene: 271212   Ensembl: ENSG000001043717   OMIM: 6054175   UniProtKB: Q9UBT33   

Export aliases for DKK4 gene to outside databases

Previous GC identifers: GC08P041716 GC08M042257 GC08M041972 GC08M042350 GC08M040754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DKK4 Gene:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine
rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.
Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DKK4 Gene:
DKK4 (dickkopf WNT signaling pathway inhibitor 4) is a protein-coding gene. Diseases associated with DKK4 include idiopathic pulmonary fibrosis. An important paralog of this gene is DKK2.

UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
formation and bone disease, cancer and Alzheimer disease (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DKK4 gene promoter:
         Nkx3-1   AML1a   NRSF form 1   Nkx3-1 v1   RelA   NRSF form 2   NF-kappaB   Nkx3-1 v2   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDKK4 promoter sequence
   Search Chromatin IP Primers for DKK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DKK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2-p11.1   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.2-p11.1

DKK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M042248:  view genomic region     (about GC identifiers)

Start:
42,231,586 bp from pter      End:
42,234,750 bp from pter
Size:
3,165 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3 (See protein sequence)
Recommended Name: Dickkopf-related protein 4 precursor  
Size: 224 amino acids; 24876 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Secondary accessions: Q3KNX0 Q9Y4C3

Explore the universe of human proteins at neXtProt for DKK4: NX_Q9UBT3

Explore proteomics data for DKK4 at MOPED

Post-translational modifications: 

  • Appears to be not glycosylated1
  • Can be proteolytically processed by a furin-like protease1
  • Modification sites at neXtProt

  • See DKK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055235.1  
    ENSEMBL proteins: 
     ENSP00000220812  
    Reactome Protein details: Q9UBT3

    DKK4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DKK4 (Dkk-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DKK4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DKK4
    GenScript Custom Purified and Recombinant Proteins Services for DKK4
    Novus Biologicals DKK4 Protein
    Novus Biologicals DKK4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DKK4

     
    Search eBioscience for Proteins for DKK4 

    DKK4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DKK4 (Dkk-4)
    OriGene Antibodies for DKK4
    OriGene Custom Antibody Services for DKK4
    Novus Biologicals DKK4 Antibodies
    Abcam antibodies for DKK4
    Cloud-Clone Corp. Antibodies for DKK4
    ThermoFisher Antibody for DKK4
    LSBio Antibodies in human, mouse, rat for DKK4

    DKK4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DKK4
    R&D Systems ELISAs for DKK4 (Dkk-4)         (see all)
    GenScript Custom Assay Services for DKK4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DKK4
    Cloud-Clone Corp. CLIAs for DKK4
    Search eBioscience for ELISAs for DKK4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR006796 Dickkopf_N
     IPR023569 Prokineticin_domain

    Graphical View of Domain Structure for InterPro Entry Q9UBT3

    ProtoNet protein and cluster: Q9UBT3

    1 Blocks protein domain: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    Find genes that share domains with DKK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DKK4_HUMAN, Q9UBT3
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
    role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
    patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
    formation and bone disease, cancer and Alzheimer disease (By similarity)

         Summary: 

    During embryonic development, DKK4 as signaling molecule is secreted from the following cells:
                
    Hair: Primary Hair Placode Cells (Hair Follicle)

    It affects the following cells:       fully expand
    Dermis: Guard Dermal Papilla Cells (Dorsal Dermis), Dermal Fibroblasts (Ventral Dermis)      fully expand to see all 3 cells
    Epidermis: Basal Keratinocytes (Embryonic Epidermis)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with DKK4           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dkk4):
     normal 

    Find genes that share phenotypes with DKK4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DKK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DKK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DKK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DKK4

    miRNA
    Products:
        
    miRTarBase miRNAs that target DKK4:
    hsa-mir-335-5p (MIRT017610), hsa-mir-25-3p (MIRT050225)

    Block miRNA regulation of human, mouse, rat DKK4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DKK4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DKK4
    Predesigned siRNA for gene silencing in human, mouse, rat DKK4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DKK4

    Clone
    Products:
         
    OriGene clones in human, mouse for DKK4 (see all 5)
    OriGene ORF clones in mouse, rat for DKK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DKK4 (NM_014420)
    Sino Biological Human cDNA Clone for DKK4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DKK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DKK4
    Browse ESI BIO Cell Lines and PureStem Progenitors for DKK4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DKK4_HUMAN, Q9UBT3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with DKK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DKK4 About    
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    3WNT Signaling
    WNT Signaling
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    5Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)


    Find genes that share SuperPaths with DKK4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DKK4
        Reelin Pathway (Cajal-Retzius cells)
    WNT Signaling

    1 BioSystems Pathway for DKK4
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    2 Sino Biological Pathways for DKK4
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2 Reactome Pathways for DKK4
        negative regulation of TCF-dependent signaling by WNT ligand antagonists
    TCF dependent signaling in response to WNT


    1 Kegg Pathway  (Kegg details for DKK4):
        Wnt signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DKK4
    Interactions:

        Search GeneGlobe Interaction Network for DKK4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DKK4 (ENSP000002208124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    LEF1ENSP000002651654STRING: ENSP00000265165
    LRP5ENSP000002943044STRING: ENSP00000294304
    LRP6ENSP000002613494STRING: ENSP00000261349
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway NAS10570958

    Find genes that share ontologies with DKK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DKK4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DKK4 gene: 
    NM_014420.2  

    Unigene Cluster for DKK4:

    Dickkopf homolog 4 (Xenopus laevis)
    Hs.159311  [show with all ESTs]
    Unigene Representative Sequence: AK311714
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000220812(uc003xpb.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DKK4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DKK4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DKK4
    Predesigned siRNA for gene silencing in human, mouse, rat DKK4
    Clone
    Products:
         
    OriGene clones in human, mouse for DKK4 (see all 5)
    OriGene ORF clones in mouse, rat for DKK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DKK4 (NM_014420)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DKK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DKK4
    OriGene qSTAR qPCR primer pairs in human, mouse for DKK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DKK4
      QuantiTect SYBR Green Assays in human, mouse, rat DKK4
      QuantiFast Probe-based Assays in human, mouse, rat DKK4

    Additional mRNA sequence: 

    AB017788.1 AF177397.1 AK301609.1 AK311714.1 BC107046.2 BC107047.2 

    3 DOTS entries:

    DT.40253117  DT.91800003  DT.40287286 

    11 AceView cDNA sequences:

    BX105775 BM783647 AA565546 BM764492 BM766165 NM_014420 BE075829 AF177397 
    AB017788 AW577816 AW602863 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DKK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGATTAAG
    DKK4 Expression
    About this image


    DKK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
             Retina
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             hIPS2
    DKK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DKK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159311

    UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
    Tissue specificity: Expressed in cerebellum, T-cells, esophagus and lung

        Custom PCR Arrays for DKK4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DKK4
    OriGene qSTAR qPCR primer pairs in human, mouse for DKK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DKK4
    QuantiTect SYBR Green Assays in human, mouse, rat DKK4
    QuantiFast Probe-based Assays in human, mouse, rat DKK4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for DKK4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dkk41 , 5 dickkopf homolog 4 (Xenopus laevis)1, 5 75.72(n)1
    76.02(a)1
      8 (11.42 cM)5
    2341301  NM_145592.21  NP_663567.11 
     226240435 


    ENSEMBL Gene Tree for DKK4 (if available)
    TreeFam Gene Tree for DKK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DKK4 gene
    DKK22  DKK12  
    2 SIMAP similar genes for DKK4 using alignment to 1 protein entry:     DKK4_HUMAN:
    DKK2    DKK1

    Find genes that share paralogs with DKK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DKK4 (see all 134)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478453811,2
    --42231092(+) TCACCC/TGGGCT 1 -- ds50010--------
    rs1839981311,2
    --42231105(+) AGTGCA/CATGGT 1 -- ds50010--------
    rs101062031,2
    C,A,H--42231159(+) ATTCTC/TCTGCC 1 -- ds50014Minor allele frequency- T:0.14WA NA CSA 7
    rs1503815961,2
    --42231223(+) TTTTTA/GTATTT 1 -- ds50010--------
    rs784941111,2
    C--42231246(+) AGGGTA/TTTACA 1 -- ds50010--------
    rs1380086471,2
    --42231318(+) GTGCTA/GGGATT 1 -- ds50010--------
    rs1114318081,2
    C--42231341(+) CACCAC/TGCCTG 1 -- ds50012Minor allele frequency- T:0.33CSA 3
    rs1886409071,2
    --42231429(+) TTTCTA/GGAAAA 1 -- ds50010--------
    rs1927622541,2
    C--42231503(+) TCAGGC/TTATTT 1 -- ds50010--------
    rs3725543051,2
    C--42231570(+) ATGTCC/TAAGAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DKK4 (42231586 - 42234750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DKK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831301CNV Loss17160897

    Human Gene Mutation Database (HGMD): DKK4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DKK4
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605417    OMIM disorders: --

    1 disease for DKK4:    
    About MalaCards
    idiopathic pulmonary fibrosis


    Find genes that share disorders with DKK4           About GenesLikeMe

    Genetic Association Database (GAD): DKK4
    Human Genome Epidemiology (HuGE) Navigator: DKK4 (7 documents)

    Export disorders for DKK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DKK4 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DKK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3, 9 Krupnik V.E.... McCarthy S.A. (Gene 1999)
    2. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 4, 9 Hirata H....Dahiya R. (Cancer 2009)
    3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4. (PubMed id 17553464)1, 4 Proitsi P....Lovestone S. (Biol. Psychiatry 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. Assignment of the human dickkopf (Xenopus) homolog 4 (DKK4) to chromosome 8p11.2--&gt;p11.1 by fluorescence in situ hybridization. (PubMed id 11701963)1, 3 Yoshida S....Tate G. (Cytogenet. Cell Genet. 2001)
    9. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. (PubMed id 18408752)1, 9 PendA!s-Franco N....GonzA!lez-Sancho J.M. (Oncogene 2008)
    10. Genome-wide copy number variation study in anorectal malformations. (PubMed id 23108157)1 Wong E.H....Garcia-Barcelo M.M. (Hum. Mol. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27121 HGNC: 2894 AceView: DKK4 Ensembl:ENSG00000104371 euGenes: HUgn27121
    ECgene: DKK4 Kegg: 27121 H-InvDB: DKK4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DKK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DKK4 gene:
    Search GeneIP for patents involving DKK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for DKK4 (Dkk-4)   Browse Cell Culture Products  
     ELISAs for DKK4 (Dkk-4)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for DKK4 (Dkk-4)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for DKK4 (Dkk-4)  
     OriGene Antibodies for DKK4   OriGene RNAi products in human, mouse, rat for DKK4  
     OriGene qPCR primer pairs and template standards for DKK4   OriGene Protein Over-expression Lysate for DKK4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DKK4  
     OriGene qSTAR qPCR primer pairs in human, mouse for DKK4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DKK4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DKK4   OriGene Custom Protein Services for DKK4  

     
     
     Block miRNA regulation of human, mouse, rat DKK4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DKK4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DKK4 Predesigned siRNA for gene silencing in human, mouse, rat DKK4
     QuantiFast Probe-based Assays in human, mouse, rat DKK4 QuantiTect SYBR Green Assays in human, mouse, rat DKK4
     Custom PCR Arrays for DKK4 Search Chromatin IP Primers for DKK4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DKK4  Search GeneGlobe Interaction Network for DKK4
     Regulatory tfbs in DKK4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DKK4 GenScript cDNA clones with any tag delivered in your preferred vector for DKK4
     GenScript Custom Assay Services for DKK4 GenScript Custom overexpressing Cell Line Services for DKK4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DKK4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DKK4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DKK4 antibodies
     DKK4 proteins
     DKK4 lysates
     Antibodies for DKK4
     See all of Abcam's Antibodies, Kits and Proteins for DKK4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DKK4
     Antibodies for DKK4
     ELISAs for DKK4
     CLIAs for DKK4



     Browse ESI BIO Cell Lines and PureStem Progenitors for DKK4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DKK4
     SwitchGear Promoter luciferase reporter plasmids for DKK4
     ThermoFisher Antibody for DKK4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DKK4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DKK4
     LSBio Antibodies in human, mouse, rat for DKK4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DKK4
      Search eBioscience for proteins for DKK4
      Search eBioscience for elisas for DKK4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DKK4 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4