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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DKK4 Gene

protein-coding   GIFtS: 52
GCID: GC08M042248

dickkopf homolog 4 (Xenopus laevis)

(Previous name: dickkopf (Xenopus laevis) homolog 4 )
 Explore 7 diseases affiliated with
DKK4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DKK4    

Aliases
for DKK4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dickkopf Homolog 4 (Xenopus Laevis)1 2     Dickkopf-43
HDkk-41     Dickkopf-Related Protein 42
Dickkopf (Xenopus Laevis) Homolog 41     Dickkopf-43
DKK-42     Dkk-43

External Ids:    HGNC: 28941   Entrez Gene: 271212   Ensembl: ENSG000001043717   OMIM: 6054175   UniProtKB: Q9UBT33   

Export aliases for DKK4 gene to outside databases

Previous GC identifers: GC08P041716 GC08M042257 GC08M041972 GC08M042350 GC08M040754


Summaries
for DKK4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DKK4:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich
regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of
this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in
vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,
limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone
disease, cancer and Alzheimer disease (By similarity)




Genomic Views
for DKK4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DKK4 gene promoter:
         Nkx3-1   AML1a   NRSF form 1   Nkx3-1 v1   RelA   NRSF form 2   NF-kappaB   Nkx3-1 v2   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DKK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DKK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2-p11.1   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.2-p11.1

DKK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M042248:  view genomic region     (about GC identifiers)

Start:
 42,231,586 bp from pter      End:
 42,234,750 bp from pter
Size:
 3,165 bases      Orientation:
 minus strand

Proteins
for DKK4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3 (See protein sequence)
Recommended Name: Dickkopf-related protein 4 precursor  
Size: 224 amino acids; 24876 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Subcellular location: Secreted
Secondary accessions: Q3KNX0 Q9Y4C3

Explore the universe of human proteins at neXtProt for DKK4: NX_Q9UBT3

Post-translational modifications:

  • Appears to be not glycosylated1
  • Can be proteolytically processed by a furin-like protease1
  • View neXtProt modification sites for NX_Q9UBT3

    • DKK4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055235.1  
    ENSEMBL proteins: 
     ENSP00000220812  

    Human Recombinant Protein Products: 
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    Novus Biologicals DKK4 Protein
    Novus Biologicals DKK4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DKK4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--


    DKK4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DKK4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DKK4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006796 Dickkopf_N
     IPR023569 Prokineticin_domain

    Graphical View of Domain Structure for InterPro Entry Q9UBT3

    ProtoNet protein and cluster: Q9UBT3

    1 Blocks protein family: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    Function
    for DKK4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in
    vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,
    limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone
    disease, cancer and Alzheimer disease (By similarity)

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK4 

    Cell Line
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    Search LifeMap BioReagents cell lines for DKK4

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DKK4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--


    DKK4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for DKK4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Reelin Pathway (Cajal-Retzius cells)
    		Reelin Pathway (Cajal-Retzius cells)1.00
    2Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00
    3WNT Signaling
    		WNT Signaling1.00
    4Wnt Signaling Pathway
    		Wnt signaling pathway0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DKK4
        Reelin Pathway (Cajal-Retzius cells)
    WNT Signaling

    1 BioSystems Pathway for DKK4 
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1         Kegg Pathway  (Kegg details for DKK4):
        Wnt signaling pathway


    DKK4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DKK4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DKK4 (ENSP000002208124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    LEF1ENSP000002651654STRING: ENSP00000265165
    LRP5ENSP000002943044STRING: ENSP00000294304
    LRP6ENSP000002613494STRING: ENSP00000261349
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway NAS10570958


    DKK4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DKK4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DKK4
    Search CenterWatch for drugs/clinical trials and news about DKK4 

    Transcripts
    for DKK4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DKK4 gene: 
    NM_014420.2  

    Unigene Cluster for DKK4:

    Dickkopf homolog 4 (Xenopus laevis)
    Hs.159311  [show with all ESTs]
    Unigene Representative Sequence: AK311714
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000220812(uc003xpb.3)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DKK4 (see all 7)
    OriGene shRNA RFP: DKK4
    OriGene siRNA: DKK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DKK4
    Clone
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    GenScript: all cDNA clones in your preferred vector: DKK4 (NM_014420)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DKK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK4 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DKK4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DKK4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DKK4

    Additional cDNA sequence: 

    AB017788.1 AF177397.1 AK301609.1 AK311714.1 BC107046.2 BC107047.2 

    3 DOTS entries:

    DT.40253117  DT.91800003  DT.40287286 

    11 AceView cDNA sequences:

    BM783647 AA565546 BM766165 BX105775 BM764492 NM_014420 AB017788 BE075829 
    AF177397 AW577816 AW602863 

    GeneLoc Exon Structure


    Expression
    for DKK4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DKK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCGATTAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DKK4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesendoderm-like cells (A scalable, suspensi...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DKK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DKK4

    SOURCE GeneReport for Unigene cluster: Hs.159311

    UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
    Tissue specificity: Expressed in cerebellum, T-cells, esophagus and lung

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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DKK4

    Orthologs
    for DKK4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for DKK4 (if available)
    TreeFam Gene Tree for DKK4 (if available) 

    Paralogs
    for DKK4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DKK4 gene
    DKK22  DKK12  
    2 SIMAP similar genes for DKK4 using alignment to 1 protein entry:     DKK4_HUMAN:
    DKK2    DKK1

    DKK4 for paralogs           About GeneDecksing



    Genomic Variants
    for DKK4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/112 NCBI SNPs in DKK4 are shown (see all 112)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1478453811,2
    		--42231092(+) TCACCC/TGGGCT 1 -- ds50010--------
    rs1839981311,2
    		--42231105(+) AGTGCA/CATGGT 1 -- ds50010--------
    rs101062031,2
    		C,A,H,--42231159(+) ATTCTC/TCTGCC 1 -- ds50014Minor allele frequency- T:0.14WA NA CSA 7
    rs1503815961,2
    		--42231223(+) TTTTTA/GTATTT 1 -- ds50010--------
    rs784941111,2
    		C--42231246(+) AGGGTA/TTTACA 1 -- ds50010--------
    rs1380086471,2
    		--42231318(+) GTGCTA/GGGATT 1 -- ds50010--------
    rs1886409071,2
    		--42231429(+) TTTCTA/GGAAAA 1 -- ds50010--------
    rs1927622541,2
    		--42231503(+) TCAGGC/TTATTT 1 -- ds50010--------
    rs2020615841,2
    		--42231652(+) TTAATC/TGAGCA 2 Q R mis10--------
    rs2012919611,2
    		--42231665(+) CTGCCA/GATTGC 2 R W mis10--------

    HapMap Linkage Disequilibrium report for DKK4 (42231586 - 42234750 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DKK4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DKK4
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK4

    Disorders / Diseases
    for DKK4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DKK4 for disorders           About GeneDecksing

    OMIM gene information: 605417    OMIM disorders: --

    7 diseases for DKK4:    About MalaCards
    idiopathic pulmonary fibrosis    pulmonary fibrosis    fibrosis    alzheimer's disease
    colon cancer    schizophrenia    colorectal cancer

    Human Genome Epidemiology (HuGE) Navigator: DKK4 (7 documents)

    Export disorders for DKK4 gene to outside databases

    Publications
    for DKK4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DKK4 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with DKK4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3, 9 Krupnik V.E.... McCarthy S.A. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    4. Assignment of the human dickkopf (Xenopus) homolog 4 (DKK4) to chromosome 8p11.2-->p11.1 by fluorescence in situ hybridization. (PubMed id 11701963)1, 3 Yoshida S....Tate G. (2001)
    5. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. (PubMed id 18408752)1, 9 Pendas-Franco N....Gonzalez-Sancho J.M. (2008)
    6. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 9 Hirata H....Dahiya R. (2009)
    7. Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4. (PubMed id 22740476)1 Lim J.W....Simpson R.J. (2012)
    8. TFAP2E-DKK4 and chemoresistance in colorectal cancer. (PubMed id 22216841)1 Ebert M.P....Schmid R.M. (2012)
    9. Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells. (PubMed id 21994129)1 Liao C.H....Lin K.H. (2012)
    10. Dickkopf 4 (DKK4) acts on Wnt/b-catenin pathway by inf luencing b-catenin in hepatocellular carcinoma. (PubMed id 22249261)1 Fatima S....Luk J.M. (2012)

    External Searches for DKK4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DKK4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27121 HGNC: 2894 AceView: DKK4 Ensembl:ENSG00000104371 euGenes: HUgn27121
    ECgene: DKK4 Kegg: 27121 H-InvDB: DKK4

    Other Databases showing DKK4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DKK4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DKK4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DKK4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DKK4 gene:
    Search GeneIP for patents involving DKK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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