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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DKK4 Gene

protein-coding   GIFtS: 55
GCID: GC08M042248

Dickkopf WNT Signaling Pathway Inhibitor 4

(Previous names: dickkopf (Xenopus laevis) homolog 4, dickkopf homolog 4...)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dickkopf WNT Signaling Pathway Inhibitor 41 2     dickkopf-42
hDkk-42 3     Dickkopf-Related Protein 42
Dickkopf (Xenopus Laevis) Homolog 41     Dickkopf-43
Dickkopf Homolog 4 (Xenopus Laevis)1     Dkk-43
DKK-42     

External Ids:    HGNC: 28941   Entrez Gene: 271212   Ensembl: ENSG000001043717   OMIM: 6054175   UniProtKB: Q9UBT33   

Export aliases for DKK4 gene to outside databases

Previous GC identifers: GC08P041716 GC08M042257 GC08M041972 GC08M042350 GC08M040754


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DKK4 Gene:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine
rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.
Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DKK4 Gene: 
DKK4 (dickkopf WNT signaling pathway inhibitor 4) is a protein-coding gene. Diseases associated with DKK4 include idiopathic pulmonary fibrosis, and pulmonary fibrosis, and among its related super-pathways are Non-Canonical Wnt Pathway and Wnt Signaling Pathway. GO annotations related to this gene include molecular_function. An important paralog of this gene is DKK2.

UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
formation and bone disease, cancer and Alzheimer disease (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DKK4 gene promoter:
         Nkx3-1   AML1a   NRSF form 1   Nkx3-1 v1   RelA   NRSF form 2   NF-kappaB   Nkx3-1 v2   AREB6   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDKK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DKK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2-p11.1   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.2-p11.1

DKK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M042248:  view genomic region     (about GC identifiers)

Start:
42,231,586 bp from pter      End:
42,234,750 bp from pter
Size:
3,165 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3 (See protein sequence)
Recommended Name: Dickkopf-related protein 4 precursor  
Size: 224 amino acids; 24876 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Subcellular location: Secreted
Secondary accessions: Q3KNX0 Q9Y4C3

Explore the universe of human proteins at neXtProt for DKK4: NX_Q9UBT3

Explore proteomics data for DKK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Appears to be not glycosylated
  • UniProtKB: Can be proteolytically processed by a furin-like protease
  • View neXtProt modification sites for NX_Q9UBT3

  • DKK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DKK4 Protein Expression
    REFSEQ proteins: NP_055235.1  
    ENSEMBL proteins: 
     ENSP00000220812  

    Human Recombinant Protein Products for DKK4: 
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    Novus Biologicals DKK4 Protein
    Novus Biologicals DKK4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DKK4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    DKK4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for DKK4 
    Cloud-Clone Corp. CLIAs for DKK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006796 Dickkopf_N
     IPR023569 Prokineticin_domain

    Graphical View of Domain Structure for InterPro Entry Q9UBT3

    ProtoNet protein and cluster: Q9UBT3

    1 Blocks protein domain: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    DKK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DKK4_HUMAN, Q9UBT3
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
    role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
    patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
    formation and bone disease, cancer and Alzheimer disease (By similarity)

         Summary:

    During embryonic development, DKK4 as signaling molecule is secreted from the following cells: Primary Hair Placode Cells in Hair Follicle It affects the following cells: Basal Keratinocytes in Embryonic Epidermis, Dermal Fibroblasts in Dorsal Dermis (see all 4).

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    DKK4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DKK4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DKK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DKK4 
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    miRNA
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DKK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    3Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    4Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)
    5WNT Signaling
    WNT Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DKK4
        Reelin Pathway (Cajal-Retzius cells)
    WNT Signaling

    1 BioSystems Pathway for DKK4
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    2 Sino Biological Pathways for DKK4 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


    1         Kegg Pathway  (Kegg details for DKK4):
        Wnt signaling pathway


    DKK4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DKK4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DKK4 (ENSP000002208124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    LEF1ENSP000002651654STRING: ENSP00000265165
    LRP5ENSP000002943044STRING: ENSP00000294304
    LRP6ENSP000002613494STRING: ENSP00000261349
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway NAS10570958

    DKK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DKK4

    Search CenterWatch for drugs/clinical trials and news about DKK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DKK4 gene: 
    NM_014420.2  

    Unigene Cluster for DKK4:

    Dickkopf homolog 4 (Xenopus laevis)
    Hs.159311  [show with all ESTs]
    Unigene Representative Sequence: AK311714
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000220812(uc003xpb.3)

    miRNA
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    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK4
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                         Customized lentivirus expression plasmids for stable overexpression of DKK4 
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    OriGene qPCR primer pairs and template standards for DKK4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DKK4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DKK4

    Additional mRNA sequence: 

    AB017788.1 AF177397.1 AK301609.1 AK311714.1 BC107046.2 BC107047.2 

    3 DOTS entries:

    DT.40253117  DT.91800003  DT.40287286 

    11 AceView cDNA sequences:

    BM783647 BX105775 AA565546 BM764492 BM766165 BE075829 AF177397 AB017788 
    NM_014420 AW577816 AW602863 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DKK4 expression in normal human tissues (normalized intensities)      DKK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGATTAAG
    DKK4 Expression
    About this image


    DKK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Primary Hair Placode Cells Hair Follicle
             mouse/organ system/integumental system   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e16.5   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles

    See DKK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DKK4

    SOURCE GeneReport for Unigene cluster: Hs.159311

    UniProtKB/Swiss-Prot: DKK4_HUMAN, Q9UBT3
    Tissue specificity: Expressed in cerebellum, T-cells, esophagus and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for DKK4 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dkk41 , 5 dickkopf homolog 4 (Xenopus laevis)1, 5 75.72(n)1
    76.02(a)1
      8 (11.42 cM)5
    2341301  NM_145592.21  NP_663567.11 
     226240435 


    ENSEMBL Gene Tree for DKK4 (if available)
    TreeFam Gene Tree for DKK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DKK4 gene
    DKK22  DKK12  
    2 SIMAP similar genes for DKK4 using alignment to 1 protein entry:     DKK4_HUMAN:
    DKK2    DKK1

    DKK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/134 SNPs in DKK4 are shown (see all 134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478453811,2
    --42231092(+) TCACCC/TGGGCT 1 -- ds50010--------
    rs1839981311,2
    --42231105(+) AGTGCA/CATGGT 1 -- ds50010--------
    rs101062031,2
    C,A,H--42231159(+) ATTCTC/TCTGCC 1 -- ds50014Minor allele frequency- T:0.14WA NA CSA 7
    rs1503815961,2
    --42231223(+) TTTTTA/GTATTT 1 -- ds50010--------
    rs784941111,2
    C--42231246(+) AGGGTA/TTTACA 1 -- ds50010--------
    rs1380086471,2
    --42231318(+) GTGCTA/GGGATT 1 -- ds50010--------
    rs1114318081,2
    C--42231341(+) CACCAC/TGCCTG 1 -- ds50012Minor allele frequency- T:0.33CSA 3
    rs1886409071,2
    --42231429(+) TTTCTA/GGAAAA 1 -- ds50010--------
    rs1927622541,2
    C--42231503(+) TCAGGC/TTATTT 1 -- ds50010--------
    rs3725543051,2
    C--42231570(+) ATGTCC/TAAGAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DKK4 (42231586 - 42234750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DKK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831301CNV Loss17160897


    Human Gene Mutation Database (HGMD): DKK4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DKK4
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605417    OMIM disorders: --

    8 diseases for DKK4:    About MalaCards
    idiopathic pulmonary fibrosis    pulmonary fibrosis    schizophrenia    colon cancer
    alzheimer's disease    colorectal cancer    hepatocellular carcinoma    thyroiditis


    DKK4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): DKK4
    Human Genome Epidemiology (HuGE) Navigator: DKK4 (7 documents)

    Export disorders for DKK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DKK4 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with DKK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3, 9 Krupnik V.E.... McCarthy S.A. (1999)
    2. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 4, 9 Hirata H....Dahiya R. (2009)
    3. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    5. Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4. (PubMed id 17553464)1, 4 Proitsi P....Lovestone S. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. Assignment of the human dickkopf (Xenopus) homolog 4 (DKK4) to chromosome 8p11.2-->p11.1 by fluorescence in situ hybridization. (PubMed id 11701963)1, 3 Yoshida S....Tate G. (2001)
    9. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. (PubMed id 18408752)1, 9 Pendas-Franco N....Gonzalez-Sancho J.M. (2008)
    10. Genome-wide copy number variation study in anorectal m alformations. (PubMed id 23108157)1 Wong E.H....Garcia-Barcelo M.M. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27121 HGNC: 2894 AceView: DKK4 Ensembl:ENSG00000104371 euGenes: HUgn27121
    ECgene: DKK4 Kegg: 27121 H-InvDB: DKK4

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DKK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for DKK4 gene:
    Search GeneIP for patents involving DKK4

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