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Aliases for DKK4 Gene

Aliases for DKK4 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 4 2 3
  • Dickkopf-4 3 4
  • HDkk-4 3 4
  • DKK-4 3 4
  • Dickkopf (Xenopus Laevis) Homolog 4 2
  • Dickkopf Homolog 4 (Xenopus Laevis) 2
  • Dickkopf-Related Protein 4 3

External Ids for DKK4 Gene

Summaries for DKK4 Gene

Entrez Gene Summary for DKK4 Gene

  • This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK4 Gene

DKK4 (Dickkopf WNT Signaling Pathway Inhibitor 4) is a Protein Coding gene. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Wnt signaling pathway (KEGG). An important paralog of this gene is DKK1.

UniProtKB/Swiss-Prot for DKK4 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK4 Gene

Genomics for DKK4 Gene

Genomic Location for DKK4 Gene

Start:
42,374,068 bp from pter
End:
42,377,232 bp from pter
Size:
3,165 bases
Orientation:
Minus strand

Genomic View for DKK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DKK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK4 Gene

Regulatory Elements for DKK4 Gene

Proteins for DKK4 Gene

  • Protein details for DKK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBT3-DKK4_HUMAN
    Recommended name:
    Dickkopf-related protein 4
    Protein Accession:
    Q9UBT3
    Secondary Accessions:
    • Q3KNX0
    • Q9Y4C3

    Protein attributes for DKK4 Gene

    Size:
    224 amino acids
    Molecular mass:
    24876 Da
    Quaternary structure:
    • Interacts with LRP5 and LRP6.

neXtProt entry for DKK4 Gene

Proteomics data for DKK4 Gene at MOPED

Post-translational modifications for DKK4 Gene

Other Protein References for DKK4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DKK4 Gene

Domains for DKK4 Gene

Protein Domains for DKK4 Gene

UniProtKB/Swiss-Prot:

DKK4_HUMAN
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.:
    • Q9UBT3
Family:
  • Belongs to the dickkopf family.:
    • Q9UBT3
genes like me logo Genes that share domains with DKK4: view

No data available for Gene Families for DKK4 Gene

Function for DKK4 Gene

Molecular function for DKK4 Gene

UniProtKB/Swiss-Prot Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

LifeMap Function Summary for DKK4 Gene

During embryonic development, DKK4 as signaling molecule is secreted from the following cells

Gene Ontology (GO) - Molecular Function for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DKK4: view

Phenotypes for DKK4 Gene

MGI mutant phenotypes for DKK4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with DKK4: view

miRNA for DKK4 Gene

miRTarBase miRNAs that target DKK4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DKK4 Gene

Localization for DKK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DKK4 Gene COMPARTMENTS Subcellular localization image for DKK4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DKK4: view

Pathways for DKK4 Gene

genes like me logo Genes that share pathways with DKK4: view

Pathways by source for DKK4 Gene

2 Sino Biological pathways for DKK4 Gene
2 Qiagen pathways for DKK4 Gene
1 KEGG pathway for DKK4 Gene

Interacting Proteins for DKK4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000220812%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000265165%0d%0a9606.ENSP00000261349%0d%0a
Selected Interacting proteins: ENSP00000220812 for DKK4 Gene via STRING

Gene Ontology (GO) - Biological Process for DKK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway NAS 10570958
genes like me logo Genes that share ontologies with DKK4: view

Transcripts for DKK4 Gene

mRNA/cDNA for DKK4 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DKK4 Gene

Dickkopf homolog 4 (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DKK4 Gene

No ASD Table

Relevant External Links for DKK4 Gene

GeneLoc Exon Structure for
DKK4
ECgene alternative splicing isoforms for
DKK4

Expression for DKK4 Gene

mRNA expression in normal human tissues for DKK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DKK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.8), Esophagus - Mucosa (5.9), Brain - Cerebellum (5.6), and Vagina (5.5).

SOURCE GeneReport for Unigene cluster for DKK4 Gene Hs.159311

mRNA Expression by UniProt/SwissProt for DKK4 Gene

Q9UBT3-DKK4_HUMAN
Tissue specificity: Expressed in cerebellum, T-cells, esophagus and lung
genes like me logo Genes that share expressions with DKK4: view

Orthologs for DKK4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DKK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKK4 36
  • 99.55 (n)
  • 99.11 (a)
DKK4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DKK4 37
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DKK4 36
  • 84.25 (n)
  • 80.73 (a)
DKK4 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dkk4 36
  • 75.72 (n)
  • 76.02 (a)
Dkk4 16
Dkk4 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DKK4 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dkk4 36
  • 75.11 (n)
  • 76.47 (a)
Species with no ortholog for DKK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DKK4 Gene

ENSEMBL:
Gene Tree for DKK4 (if available)
TreeFam:
Gene Tree for DKK4 (if available)

Paralogs for DKK4 Gene

Paralogs for DKK4 Gene

Selected SIMAP similar genes for DKK4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DKK4: view

Variants for DKK4 Gene

Sequence variations from dbSNP and Humsavar for DKK4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2073663 -- 42,374,642(-) AGCAT(A/G)TGCTG intron-variant
rs2073664 -- 42,374,268(-) CCAGT(C/T)CTTTT reference, synonymous-codon
rs2073665 -- 42,374,971(-) TAGTG(C/T)GTCTG intron-variant
rs3763511 -- 42,378,340(-) AGATT(C/T)ATGTC upstream-variant-2KB
rs4442132 -- 42,373,798(-) TCCCA(G/T)CACTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DKK4 Gene

Variant ID Type Subtype PubMed ID
nsv831301 CNV Loss 17160897

Relevant External Links for DKK4 Gene

HapMap Linkage Disequilibrium report
DKK4
Human Gene Mutation Database (HGMD)
DKK4

Disorders for DKK4 Gene

Relevant External Links for DKK4

Genetic Association Database (GAD)
DKK4
Human Genome Epidemiology (HuGE) Navigator
DKK4
genes like me logo Genes that share disorders with DKK4: view

No data available for UniProtKB/Swiss-Prot for DKK4 Gene

Publications for DKK4 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4 23
  2. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H. … Dahiya R. (Cancer 2009) 3 23 49
  3. Assignment of the human dickkopf (Xenopus) homolog 4 (DKK4) to chromosome 8p11.2-->p11.1 by fluorescence in situ hybridization. (PMID: 11701963) Yoshida S. … Tate G. (Cytogenet. Cell Genet. 2001) 2 3
  4. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. (PMID: 18408752) PendA!s-Franco N. … GonzA!lez-Sancho J.M. (Oncogene 2008) 3 23
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 49

Products for DKK4 Gene

Sources for DKK4 Gene

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