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DKK3 Gene

protein-coding GIFtS: 59

GC11M011941

dickkopf homolog 3 (Xenopus laevis)
(Previous name: dickkopf (Xenopus laevis) homolog 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Dickkopf-3 ^³
Dkk-3 ^³
REIC ^¹, ², ³
RIG ^²
hDkk-3 ^³

Descriptions
RIG-like 5-6 ^²
RIG-like 7-1 ^²
dickkopf (Xenopus laevis) homolog 3 ^¹
dickkopf 3 ^²
dickkopf homolog 3 ^²
dickkopf homolog 3 (Xenopus laevis) ^²
regulated in glioma ^²

External Ids
HGNC: 2893¹
Entrez Gene: 27122²
UniProtKB: Q9UBP4³
Ensembl: ENSG00000050165⁷

Search outside databases for aliases for DKK3 gene

Previous GC identifers: GC11M013255 GC11M012554 GC11M012023 GC11M011948

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DKK3:

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains

two cysteine rich regions and is involved in embryonic development through its interactions with

the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell

lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple

transcript variants encoding the same protein. [provided by RefSeq]

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4

Function: Inhibitor of Wnt signaling pathway (Potential)

Gene Wiki entry for DKK3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DKK3 gene

Entrez Gene cytogenetic band: 11p15.2 Ensembl cytogenetic band: 11p15.3 HGNC cytogenetic band: 11p15.3

DKK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M011941: (about GC identifiers)

Start:	11,941,119 bp from pter
End:	11,987,493 bp from pter
Size:	46,375 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4 (See protein sequence)

Recommended Name: Dickkopf-related protein 3 precursor

Size: 350 amino acids; 38291 Da

Subcellular location: Secreted

Secondary accessions: Q9ULB7

Post-translational modifications:

N-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001018067.1 NP_037385.2 NP_056965.3

ENSEMBL proteins:

ENSP00000314730 ENSP00000314910 ENSP00000379762

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for DKK3 (Dkk-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (350 aa isoform DKK3)
	Human Recombinant Proteins from Abnova (DKK3)

OriGene Purified Recombinant Human Protein: DKK3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	10570958

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Antibodies for DKK3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DKK3
	R&D Systems Antibodies for DKK3 (Dkk-3)
	Antibodies from Abcam (350 aa isoform DKK3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for DKK3

Assays for DKK3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for DKK3 (Dkk-3) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UBP4

ProtoNet protein and cluster: Q9UBP4

1 Blocks protein family: IPB006796 Dickkopf

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4

Similarity: Belongs to the dickkopf family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DKK3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DKK3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_013253

Applied Biosystems Silencer® siRNAs for DKK3

Sigma-Aldrich siRNA for DKK3

Sigma-Aldrich shRNA for DKK3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DKK3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001018057
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001018057
untagged cDNA clones in CMV expression vector (see all 4): NM_001018057

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001018057

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4

Function: Inhibitor of Wnt signaling pathway (Potential)

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dkk3):

behavior/neurological

hematopoietic system

immune system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for DKK3 (Your Favorite Gene powered by Ingenuity)

Wnt/&beta

GeneDecks DKK3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DKK3

5/13 Interacting proteins for DKK3 (ENSP00000314910³ Q9UBP4²) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LRP6	ENSP00000261349³	STRING (score=.961)
WNT6	ENSP00000233948³	STRING (score=.944)
WNT2B	ENSP00000358698³	STRING (score=.911)
FZD8	ENSP00000363826³	STRING (score=.862)
SFRP1	ENSP00000220772³	STRING (score=.849)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0009653	anatomical structure morphogenesis	TAS	10570958
GO:0030178	negative regulation of Wnt receptor signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DKK3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DKK3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DKK3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_013253

Sigma-Aldrich siRNA for DKK3

Sigma-Aldrich shRNA for DKK3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001018057 NM_013253 NM_015881

REFSEQ mRNAs for DKK3 gene (3 alternative transcripts):

NM_001018057.1 NM_013253.4 NM_015881.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001018057 NM_013253 NM_015881

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001018057
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001018057
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001018057

Additional cDNA sequence:

AB033421.1 AB034203.1 AB057591.1 AF052161.1 AF177396.1 AF400439.1 AK092979.1 AK098756.1

AK225156.1 AK289897.1 AK295441.1 AK295539.1 AY358378.1 AY587550.1 BC007660.2 CR607734.1

U32331.1

22 DOTS entries:

DT.418939 DT.100816741 DT.91767127 DT.40299804 DT.100816739 DT.95156379 DT.97765245 DT.120734819

DT.410173 DT.120734800 DT.120734838 DT.95156382 DT.91767118 DT.120734840 DT.100816735 DT.100819188

DT.102824245 DT.120734797 DT.120734859 DT.121627162 DT.101968117 DT.92466268

24/451 AceView cDNA sequences (see all 451 ):

BQ690088 BF724383 AA668448 BQ687864 BM511891 BM704826 BQ689566 BU157606

AA844276 AK092979 BU190780 CF131317 BU157365 CD624670 BQ897122 AA652462

NM_013253 BU163369 BM693391 BQ719036 BU185935 AI199529 BU683488 AA226842

highest scoring ESTs for DKK3:

AB057591 AY358378 BE910066 BG701274 BG702538 BI550000 BI553362 BI596318 BQ670374 BQ876718

Unigene Cluster for DKK3:

Dickkopf homolog 3 (Xenopus laevis)

Hs.292156 [show with all ESTs]

Unigene Representative Sequence: NM_015881

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DKK3 (see all 17 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·
SP1:							-		-		-		-		-		-														-		-		-				-		-		-		-
SP2:															-		-														-		-		-				-		-		-		-
SP3:													-		-		-														-		-		-				-		-		-		-
SP4:																															-		-		-				-		-		-		-
SP5:																																											-		-

ExUns:	13b	·	13c	^	14a	·	14b	·	14c	·	14d	·	14e	^	15a	·	15b	^	16
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DKK3

3 Ensembl transcripts including schematic representations:

ENST00000326914 ENST00000326932 ENST00000396505

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DKK3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DKK3

¹ / ² / ³

8 probe-sets matching DKK3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
214247_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU148057	0.60	0.75	0.68	1
221126_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006394	0.20	1.00	0.72	1
202196_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_013253	0.60	1.00	0.82	1
221127_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006394	0.20	1.00	0.72	1
214247_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221126_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202196_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221127_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTTCTTTGA

SOURCE GeneReport for Unigene cluster: Hs.292156
UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
Tissue specificity: Highest expression in heart, brain, and spinal cord

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DKK3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DKK3¹	--	dickkopf homolog 3 (Xenopus laevis)	88.04(n) 85.14(a)	476857 XM_534060.2 XP_534060.2
chimpanzee (Pan troglodytes)	DKK3¹	--	dickkopf homolog 3 (Xenopus laevis)	99.05(n) 98.29(a)	451030 XM_001171252.1 XP_001171252.1
cow (Bos taurus)	DKK3¹	--	dickkopf homolog 3 (Xenopus laevis)	88.83(n) 87.97(a)	506627 XM_583102.3 XP_583102.3
rat (Rattus norvegicus)	Dkk3¹	--	dickkopf homolog 3 (Xenopus laevis)	82.79(n) 78.7(a)	171548 NM_138519.1 NP_612528.1
mouse (Mus musculus)	Dkk3^{1, 5}	7⁵	dickkopf homolog 3 (Xenopus laevis)^{1, 5}	83.96(n)¹ 83(a)¹	50781¹ NM_015814.2¹ NP_056629.1¹ AA692959⁵ AF177400⁵ (see all 18)

About this table Species with no ortholog for DKK3

ENSEMBL Gene Tree for DKK3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/347 NCBI SNPs in DKK3 are shown (see all 347 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 189)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8169^1,2	A,C,F,H	11941430(+)	`GCATAT/ATACAA`	3	--	ut3¹		13		MN EU EA WA	1442
	rs3206824^1,2	A,C,F,H	11942637(-)	`CGCTGG/AGGGAG`	3	G/R	mis¹		12		MN EU EA WA NA	1162
	rs3896391^1,2	A,F	11988235(+)	`CCACAT/ATACTG`	3	--	ng3¹		4		NA EA	362
--	rs11022111^1,2	A,C	11987670(+)	`CCTGCC/GCCCGC`	3	--	ng3¹		0	--	--	--	--
--	rs12576599^1,2	A	11988837(+)	`aagaaA/Ggaaag`	2	--	ng3¹ trp³		0	--	--	--	--
--	rs11544816^1,2	H	11986559(-)	`AATGAG/TATGTT`	3	E/D	mis¹		4		EU EA WA	404
	rs12798005^1,2	H	11942689(+)	`TGGCGC/TACCTC`	3	V/V	syn¹ ese³		4		EU EA WA	420
	rs988666^1,2	A,C,F,H,O	11967072(+)	`CAGAGT/CTGGGG`	3	--	int¹		12		MN EU EA WA NA	1154
	rs1038909^1,2	A,C,F,H,O	11966903(+)	`CTCCAA/CGATGC`	3	--	int¹		12		EU EA WA NA	1054
	rs1472190^1,2	A,C,F,H,O	11945415(+)	`CAGAAC/TGCTGG`	3	--	int¹		11		NA EU EA WA	2236

About this table

HapMap Linkage Disequilibrium images for DKK3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605416

5 Novoseek disease relationships for DKK3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	40.60	4	18219095 (2), 18826564 (1)
cancer lung	36.95	6	18048388 (4), 10652205 (1)
gastric cancer	31.86	10	19051296 (7)
tumors	22.49	13	11814687 (3), 17549386 (1), 17949785 (1), 18219095 (1) (see all 9)
breast cancer	16.74	6	18826564 (4)

About this table

Human Gene Mutation Database: DKK3
Human Genome Epidemiology Navigator: DKK3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/46 PubMed articles for DKK3 gene (see all 46 ):

Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)^{2, 3, 4} Krupnik V.E.... McCarthy S.A. (1999)
Reduced expression of the REIC/Dkk-3 gene by promoter- hypermethylation in human tumor cells. (PubMed id 11814687)^{1, 3, 4} Kobayashi K.... Shimizu K. (2002)
A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. (PubMed id 10652205)^{1, 3, 4} Tsuji T.... Namba M. (2000)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours. (PubMed id 18826564)^{1, 3} Veeck J....Dahl E. (2008)
Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer. (PubMed id 19051296)^{1, 3} Yu J....Sung J.J. (2009)
Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. (PubMed id 18048388)^{1, 3} Yue W....Zhang L. (2008)
Dysregulation of Dkk-3 expression in benign and malignant prostatic tissue. (PubMed id 18247400)^{1, 3} Zenzmaier C....Berger P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 27122	HGNC: 2893	AceView: DKK3	Ensembl:ENSG00000050165	euGenes: HUgn27122
ECgene: DKK3	H-InvDB: DKK3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DKK3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DKK3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DKK3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DKK3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DKK3		Antibodies for DKK3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DKK3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DKK3)
	Search for Antibodies
	Chimera RNAi (DKK3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (350 aa isoform DKK3)
	Antibodies (350 aa isoform DKK3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for DKK3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DKK3

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DKK3 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for DKK3

Summaries
for DKK3

Genomic Location
for DKK3

Proteins
for DKK3

Protein Domains/
Families
for DKK3

Gene Function
for DKK3

Pathways & Interactions
for DKK3

Drugs & Compounds
for DKK3

Transcripts
for DKK3

Expression
for DKK3

Orthologs
for DKK3

Paralogs
for DKK3

SNPs/Variants
for DKK3

Disorders & Mutations
for DKK3

Medical News
for DKK3

Publications
for DKK3

Search for DKK3

Genome Databases showing DKK3

Other Databases showing DKK3

Specialized Databases showing DKK3

Licensable Technologies
for DKK3

Services
for DKK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DKK3 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor DKK3

Summariesfor DKK3

Genomic Locationfor DKK3

Proteinsfor DKK3

Protein Domains/Familiesfor DKK3

Gene Functionfor DKK3

Pathways & Interactionsfor DKK3

Drugs & Compoundsfor DKK3

Transcriptsfor DKK3

Expression for DKK3

Orthologsfor DKK3

Paralogsfor DKK3

SNPs/Variantsfor DKK3

Disorders & Mutationsfor DKK3

Medical Newsfor DKK3

Publicationsfor DKK3

Search for DKK3

Genome Databases showing DKK3

Other Databases showing DKK3

Specialized Databases showing DKK3

Licensable Technologiesfor DKK3

Servicesfor DKK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DKK3

Summaries
for DKK3

Genomic Location
for DKK3

Proteins
for DKK3

Protein Domains/
Families
for DKK3

Gene Function
for DKK3

Pathways & Interactions
for DKK3

Drugs & Compounds
for DKK3

Transcripts
for DKK3

Expression
for DKK3

Orthologs
for DKK3

Paralogs
for DKK3

SNPs/Variants
for DKK3

Disorders & Mutations
for DKK3

Medical News
for DKK3

Publications
for DKK3

Licensable Technologies
for DKK3

Services
for DKK3