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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DKK3 Gene

protein-coding   GIFtS: 59
GCID: GC11M011984

dickkopf 3 homolog (Xenopus laevis)

(Previous name: dickkopf (Xenopus laevis) homolog 3 )
 Explore 33 diseases affiliated with
DKK3 via
MalaCards
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 Human Malady Compendium 
Biological research products
for DKK3    

Aliases
for DKK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dickkopf 3 Homolog (Xenopus Laevis)1 2     Dickkopf-Related Protein 32
REIC1 2 3     Dkk-33
RIG1 2     Regulated In Glioma2
HDkk-31     RIG-Like 5-62
Dickkopf (Xenopus Laevis) Homolog 31     RIG-Like 7-12
Dickkopf Homolog 32     Dickkopf-33
Dickkopf-33     Dkk-33

External Ids:    HGNC: 28931   Entrez Gene: 271222   Ensembl: ENSG000000501657   OMIM: 6054165   UniProtKB: Q9UBP43   

Export aliases for DKK3 gene to outside databases

Previous GC identifers: GC11M013255 GC11M012554 GC11M012023 GC11M011948 GC11M011941 GC11M011660


Summaries
for DKK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DKK3:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich
regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The
expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene.
Alternative splicing results in multiple transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in
vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,
limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone
disease, cancer and Alzheimer disease (By similarity)

Gene Wiki entry for DKK3


Genomic Views
for DKK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DKK3 gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DKK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DKK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

DKK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M011984:  view genomic region     (about GC identifiers)

Start:
 11,984,543 bp from pter      End:
 12,031,316 bp from pter
Size:
 46,774 bases      Orientation:
 minus strand

Proteins
for DKK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4 (See protein sequence)
Recommended Name: Dickkopf-related protein 3 precursor  
Size: 350 amino acids; 38390 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Subcellular location: Secreted
Secondary accessions: A8K1I2 D3DQW1 Q9ULB7

Explore the universe of human proteins at neXtProt for DKK3: NX_Q9UBP4

Post-translational modifications:

  • N- and O-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBP4

    • DKK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001018067.1  NP_037385.2  NP_056965.3  

    ENSEMBL proteins: 
     ENSP00000379762   ENSP00000314910   ENSP00000433112   ENSP00000435269   ENSP00000436645  
     ENSP00000431604   ENSP00000398365  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: DKK3
    OriGene Protein Over-expression Lysate (see all 4): DKK3
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    Novus Biologicals DKK3 Protein
    Novus Biologicals DKK3 Lysates
    Sino Biological Recombinant Protein for DKK3
    ProSpec Recombinant Protein for DKK3
    Uscn Proteins for DKK3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS10570958


    DKK3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DKK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DKK3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006796 Dickkopf_N

    Graphical View of Domain Structure for InterPro Entry Q9UBP4

    ProtoNet protein and cluster: Q9UBP4

    1 Blocks protein family: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    Function
    for DKK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in
    vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,
    limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone
    disease, cancer and Alzheimer disease (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DKK3
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate DKK3 (see all 38):
    hsa-miR-300 hsa-let-7d hsa-miR-4272 hsa-miR-25 hsa-miR-3921 hsa-let-7g hsa-miR-3622b-3p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmid: DKK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK3 

    Cell Line
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    Search LifeMap BioReagents cell lines for DKK3

    In Situ Assay
    Products:       
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    1 GenomeRNAi human phenotype for DKK3:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Dkk3tm1Cni for DKK3
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dkk3):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system 

    DKK3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DKK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DKK3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for DKK3 (Q9UBP42, 3 ENSP000003149104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=2 STRING: ENSP00000357292
    WNK1Q9H4A33I2D: score=2 
    OPCMLQ149823I2D: score=1 
    IRAK1ENSP000003589974STRING: ENSP00000358997
    --Q777G92MINT-6770041
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0009653anatomical structure morphogenesis TAS10570958
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway ----
    GO:0030325adrenal gland development IEP12844346


    DKK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DKK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DKK3
    Search CenterWatch for drugs/clinical trials and news about DKK3 

    Transcripts
    for DKK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DKK3 gene (3 alternative transcripts): 
    NM_001018057.1  NM_013253.4  NM_015881.5  

    Unigene Clusters for DKK3:

    Dickkopf 3 homolog (Xenopus laevis)
    Hs.292156  [show with all ESTs], Hs.731954  [show with all ESTs]
    Unigene Representative Sequences: NM_015881, BG422803
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527132 ENST00000396505(uc001mjv.3) ENST00000326932(uc010rcf.2 uc001mju.3 uc001mjw.3)
    ENST00000525493(uc010rcg.1) ENST00000528188 ENST00000532372 ENST00000525927
    ENST00000532873 ENST00000533813 ENST00000534511 ENST00000529338 ENST00000526218
    ENST00000531309 ENST00000530694 ENST00000534479 ENST00000533900 ENST00000450094


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DKK3
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate DKK3 (see all 38):
    hsa-miR-300 hsa-let-7d hsa-miR-4272 hsa-miR-25 hsa-miR-3921 hsa-let-7g hsa-miR-3622b-3p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmid: DKK3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DKK3 (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DKK3

    Additional cDNA sequence: AF400439.1 

    24 DOTS entries:

    DT.418939  DT.100816741  DT.91767127  DT.40299804  DT.100816739  DT.95156379  DT.97765245  DT.120734819 
    DT.120734800  DT.100819188  DT.120734838  DT.91767118  DT.95156382  DT.120734840  DT.100816735  DT.102824245 
    DT.120734797  DT.120734859  DT.410173  DT.101968117  DT.121627162  DT.92442592  DT.92466268  DT.97779608 

    24/451 AceView cDNA sequences (see all 451):

    BQ894810 T30923 BU162929 BQ687171 Z38477 BU163369 BU190780 BU185743 
    BQ897122 BQ897670 BQ890463 BU157365 BM704826 BQ687539 AW517066 AI249754 
    BQ687864 BQ897953 NM_013253 CA390508 CF132660 BQ690088 BM819152 H99266 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DKK3 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a ·
    SP1:                    -     -     -     -     -     -                                         -     -     -           -     -     -     -                     
    SP2:                                            -     -                                         -     -     -           -     -     -     -                     
    SP3:                                      -     -     -                                         -     -     -           -     -     -     -                     
    SP4:                                                                                            -     -     -           -     -     -     -                     
    SP5:                                                                                                                                -     -                     

    ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DKK3

    Expression
    for DKK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DKK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTCTTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DKK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor CellsRetinal Pigmented Epithelium
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See DKK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DKK3

    SOURCE GeneReport for Unigene clusters: Hs.292156 Hs.731954

    UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
    Tissue specificity: Highest expression in heart, brain, and spinal cord

        SABiosciences Expression via Pathway-Focused PCR Arrays including DKK3: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK3

    Orthologs
    for DKK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DKK3 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dkk31 , 5 dickkopf homolog 3 (Xenopus laevis)1, 5 83.96(n)1
    83(a)1    		   7 (58.74 cM)5
    507811  NM_015814.21  NP_056629.11 
     1121160195 
    chicken
    (Gallus gallus)    		 Aves DKK31 dickkopf homolog 3 (Xenopus laevis) 66.56(n)
    61.26(a)    		   396023  NM_205125.1  NP_990456.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DKK36
    		 --
    		 52(a)
    		 1 ↔ 1
    		 GL343237.1(547308-584821)
    zebrafish
    (Danio rerio)    		 Actinopterygii dkk31 dickkopf homolog 3 (Xenopus laevis) 54.29(n)
    48.57(a)    		   100038765  NM_001089545.1  NP_001083014.1 


    ENSEMBL Gene Tree for DKK3 (if available)
    TreeFam Gene Tree for DKK3 (if available) 

    Paralogs
    for DKK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DKK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/956 NCBI SNPs in DKK3 are shown (see all 956)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1867814241,2
    		--11984132(+) TCACTA/GTAACC 3 -- ds50010--------
    rs1912538101,2
    		--11984143(+) TGGACA/GTACTG 3 -- ds50010--------
    rs1436805781,2
    		--11984203(+) CTCCAC/TTTGTT 3 -- ds50010--------
    rs1850819571,2
    		--11984301(+) CGCAGC/GTGACT 3 -- ds50010--------
    rs1481071711,2
    		--11984827(+) GTGGCA/GTAGAG 3 -- ut310--------
    rs1419084631,2
    		--11984842(+) GTGTTC/TGCAGT 3 -- ut310--------
    rs81691,2
    		C,F,A,H,--11984854(+) GCATAT/ATACAA 3 -- ut3121Minor allele frequency- A:0.03MN NS EA NA 2230
    rs1506459221,2
    		--11984882(+) CTGCTC/TGGTTT 3 -- ut310--------
    rs1893734751,2
    		--11984898(+) TCTCCA/GCGTGG 3 -- ut310--------
    rs1931614221,2
    		--11984909(+) TTGATA/CATTGT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for DKK3 (11984543 - 12031316 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for DKK3
         2 CNVs: 48708 48709
         2 Indels: 48707 48710
    Human Gene Mutation Database (HGMD): DKK3

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    Disorders / Diseases
    for DKK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DKK3 for disorders           About GeneDecksing

    OMIM gene information: 605416    OMIM disorders: --

    20/33 diseases for DKK3 (see all 33):    About MalaCards
    renal clear cell carcinoma    esophageal squamous cell carcinoma    squamous cell carcinoma    intrahepatic cholangiocarcinoma
    epithelial ovarian cancer    malignant glioma    retinal degeneration    ovarian cancer
    gastric cancer    cholangiocarcinoma    hepatoblastoma    breast cancer
    oral cancer    aldosteronism    lung adenocarcinoma    hepatocellular carcinoma
    cervical cancer    alzheimer's disease    esophagitis    cervicitis

    1 disease from the University of Copenhagen DISEASES database for DKK3:
    Cancer

    5 Novoseek disease relationships for DKK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 41 6 18219095 (2), 20473620 (1), 19570204 (1), 18826564 (1)
    gastric cancer 34.4 11 19051296 (7), 20473620 (1)
    tumors 31.8 21 20473620 (3), 11814687 (3), 19570204 (2), 17549386 (1) (see all 11)
    cancer lung 31.1 6 18048388 (4), 10652205 (1)
    breast cancer 17.3 11 19570204 (4), 18826564 (4)

    Human Genome Epidemiology (HuGE) Navigator: DKK3 (6 documents)

    Export disorders for DKK3 gene to outside databases

    Publications
    for DKK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DKK3 gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with DKK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3 Krupnik V.E.... McCarthy S.A. (1999)
    2. Reduced expression of the REIC/Dkk-3 gene by promoter- hypermethylation in human tumor cells. (PubMed id 11814687)1, 2, 9 Kobayashi K.... Shimizu K. (2002)
    3. A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. (PubMed id 10652205)1, 2, 9 Tsuji T.... Namba M. (2000)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours. (PubMed id 18826564)1, 9 Veeck J....Dahl E. (2008)
    9. Prognostic relevance of Wnt-inhibitory factor-1 (WIF1 ) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. (PubMed id 19570204)1, 9 Veeck J....Dahl E. (2009)
    10. Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer. (PubMed id 19051296)1, 9 Yu J....Sung J.J. (2009)

    External Searches for DKK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    Genome Databases showing DKK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27122 HGNC: 2893 AceView: DKK3 Ensembl:ENSG00000050165 euGenes: HUgn27122
    ECgene: DKK3 H-InvDB: DKK3

    Other Databases showing DKK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DKK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DKK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DKK3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DKK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DKK3 gene:
    Search GeneIP for patents involving DKK3

    GeneCards and IP:
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