Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DKK3 Gene

Aliases for DKK3 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 3 2 3 5
  • Regulated In Glioma 2 3
  • Dickkopf-3 3 4
  • HDkk-3 3 4
  • Dkk-3 3 4
  • REIC 3 4
  • Dickkopf (Xenopus Laevis) Homolog 3 2
  • Dickkopf 3 Homolog (Xenopus Laevis) 2
  • Dickkopf-Related Protein 3 3
  • Dickkopf 3 Homolog 3
  • Dickkopf Homolog 3 3
  • RIG-Like 5-6 3
  • RIG-Like 7-1 3
  • RIG 3

External Ids for DKK3 Gene

Previous GeneCards Identifiers for DKK3 Gene

  • GC11M013255
  • GC11M012554
  • GC11M012023
  • GC11M011948
  • GC11M011941
  • GC11M011660

Summaries for DKK3 Gene

Entrez Gene Summary for DKK3 Gene

  • This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK3 Gene

DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation.

UniProtKB/Swiss-Prot for DKK3 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Gene Wiki entry for DKK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK3 Gene

Genomics for DKK3 Gene

Regulatory Elements for DKK3 Gene

Enhancers for DKK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F012016 0.9 Ensembl ENCODE 31.2 -7.9 -7867 1.6 PKNOX1 BHLHE40 ZFP64 MNT GABPA MEF2D IKZF1 PBX2 HMBOX1 DKK3 LOC105376554
GH11F012048 1.1 Ensembl ENCODE 22.3 -39.4 -39427 1.4 GATA3 CEBPB DKK3 MICAL2 ENSG00000254991 LOC105376554
GH11F012046 1.3 Ensembl ENCODE 18.1 -37.3 -37332 2.2 SOX13 HDGF CTCF CBX3 MAX RAD21 YY1 RFX5 ZNF143 SMC3 DKK3 ENSG00000254991 LOC105376554
GH11F012050 0.5 Ensembl ENCODE 15.4 -41.5 -41493 1.3 ATF3 HNF4G ZBTB33 ZIC2 RAD21 NR2F2 YY1 DKK3 MICAL2 ENSG00000254991 LOC105376554
GH11F012041 1.3 FANTOM5 Ensembl ENCODE 13.5 -33.8 -33790 4.0 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS DKK3 LOC105376554 ENSG00000254991
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DKK3 on UCSC Golden Path with GeneCards custom track

Promoters for DKK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000558579 869 1801 PKNOX1 SP3 NR2F1 FOSL1 JUND POLR2A NR2F6 FOS

Genomic Location for DKK3 Gene

Chromosome:
11
Start:
11,962,996 bp from pter
End:
12,009,769 bp from pter
Size:
46,774 bases
Orientation:
Minus strand

Genomic View for DKK3 Gene

Genes around DKK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK3 Gene

Proteins for DKK3 Gene

  • Protein details for DKK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBP4-DKK3_HUMAN
    Recommended name:
    Dickkopf-related protein 3
    Protein Accession:
    Q9UBP4
    Secondary Accessions:
    • A8K1I2
    • D3DQW1
    • Q9ULB7

    Protein attributes for DKK3 Gene

    Size:
    350 amino acids
    Molecular mass:
    38390 Da
    Quaternary structure:
    • Interacts with LRP5 and LRP6.

neXtProt entry for DKK3 Gene

Post-translational modifications for DKK3 Gene

Antibody Products

No data available for DME Specific Peptides for DKK3 Gene

Domains & Families for DKK3 Gene

Protein Domains for DKK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBP4

UniProtKB/Swiss-Prot:

DKK3_HUMAN :
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Belongs to the dickkopf family.
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Family:
  • Belongs to the dickkopf family.
genes like me logo Genes that share domains with DKK3: view

No data available for Gene Families for DKK3 Gene

Function for DKK3 Gene

Molecular function for DKK3 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
genes like me logo Genes that share phenotypes with DKK3: view

Animal Models for DKK3 Gene

MGI Knock Outs for DKK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for DKK3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DKK3 Gene

Localization for DKK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DKK3 Gene COMPARTMENTS Subcellular localization image for DKK3 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DKK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,TAS --
genes like me logo Genes that share ontologies with DKK3: view

Pathways & Interactions for DKK3 Gene

genes like me logo Genes that share pathways with DKK3: view

Pathways by source for DKK3 Gene

1 Sino Biological pathway for DKK3 Gene
1 GeneTex pathway for DKK3 Gene

Interacting Proteins for DKK3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314910%0d%0a9606.ENSP00000357292%0d%0a
Selected Interacting proteins: ENSP00000314910 Q9UBP4-DKK3_HUMAN for DKK3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DKK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0009653 anatomical structure morphogenesis TAS 10570958
GO:0016055 Wnt signaling pathway IEA --
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway NAS 24431302
GO:0030178 negative regulation of Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with DKK3: view

No data available for SIGNOR curated interactions for DKK3 Gene

Transcripts for DKK3 Gene

Unigene Clusters for DKK3 Gene

Dickkopf 3 homolog (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - - -
SP9: -
SP10: - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - -
SP14:
SP15:
SP16: - - - - - - - - - - - - - - -
SP17: - - -

ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - -
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - -
SP17:

Relevant External Links for DKK3 Gene

GeneLoc Exon Structure for
DKK3
ECgene alternative splicing isoforms for
DKK3

Expression for DKK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DKK3 Gene

mRNA differential expression in normal tissues according to GTEx for DKK3 Gene

This gene is overexpressed in Heart - Atrial Appendage (x8.6).

Protein differential expression in normal tissues from HIPED for DKK3 Gene

This gene is overexpressed in Vitreous humor (34.5), Cerebrospinal fluid (16.6), and Amniocyte (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DKK3 Gene



NURSA nuclear receptor signaling pathways regulating expression of DKK3 Gene:

DKK3

SOURCE GeneReport for Unigene cluster for DKK3 Gene:

Hs.292156

mRNA Expression by UniProt/SwissProt for DKK3 Gene:

Q9UBP4-DKK3_HUMAN
Tissue specificity: Highest expression in heart, brain, and spinal cord.
genes like me logo Genes that share expression patterns with DKK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for DKK3 Gene

Orthologs for DKK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DKK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKK3 34 35
  • 99.05 (n)
cow
(Bos Taurus)
Mammalia DKK3 34 35
  • 88.83 (n)
dog
(Canis familiaris)
Mammalia DKK3 34 35
  • 88.09 (n)
mouse
(Mus musculus)
Mammalia Dkk3 34 16 35
  • 84.81 (n)
rat
(Rattus norvegicus)
Mammalia Dkk3 34
  • 83.18 (n)
oppossum
(Monodelphis domestica)
Mammalia DKK3 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DKK3 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves DKK3 34 35
  • 66.56 (n)
lizard
(Anolis carolinensis)
Reptilia DKK3 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dkk3 34
  • 54.01 (n)
dkk3b 35
  • 42 (a)
OneToMany
dkk3a 35
  • 37 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13938 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.181 35
  • 18 (a)
OneToOne
Species where no ortholog for DKK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DKK3 Gene

ENSEMBL:
Gene Tree for DKK3 (if available)
TreeFam:
Gene Tree for DKK3 (if available)

Paralogs for DKK3 Gene

No data available for Paralogs for DKK3 Gene

Variants for DKK3 Gene

Sequence variations from dbSNP and Humsavar for DKK3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1012600 -- 11,992,922(-) ATCTT(C/T)GTTTT intron-variant
rs10160790 -- 11,986,116(+) CCGGG(G/T)ACCCC intron-variant
rs1038908 -- 11,987,868(+) AAACA(C/T)ATTTA intron-variant
rs1038909 -- 11,988,780(+) CTCCA(A/C/T)GATGC intron-variant
rs1043179 -- 11,963,236(-) TTGCC(A/C)CCATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DKK3 Gene

Variant ID Type Subtype PubMed ID
esv3625384 CNV gain 21293372
esv3625386 CNV gain 21293372
nsv483000 CNV loss 15286789
nsv515847 CNV gain+loss 19592680
nsv524257 CNV loss 19592680
nsv526144 CNV loss 19592680
nsv553544 CNV gain 21841781
nsv832067 CNV gain 17160897

Variation tolerance for DKK3 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DKK3 Gene

Human Gene Mutation Database (HGMD)
DKK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DKK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKK3 Gene

Disorders for DKK3 Gene

Relevant External Links for DKK3

Genetic Association Database (GAD)
DKK3
Human Genome Epidemiology (HuGE) Navigator
DKK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DKK3

No disorders were found for DKK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DKK3 Gene

Publications for DKK3 Gene

  1. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H. … Dahiya R. (Cancer 2009) 3 22 46 64
  2. Reduced expression of the REIC/Dkk-3 gene by promoter- hypermethylation in human tumor cells. (PMID: 11814687) Kobayashi K. … Shimizu K. (Gene 2002) 3 4 22 64
  3. A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. (PMID: 10652205) Tsuji T. … Namba M. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
  4. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for DKK3 Gene

Sources for DKK3 Gene

Content
Loading form....