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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DKK3 Gene

protein-coding   GIFtS: 61
GCID: GC11M011984

Dickkopf WNT Signaling Pathway Inhibitor 3

(Previous names: dickkopf (Xenopus laevis) homolog 3, dickkopf 3 homolog...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dickkopf WNT Signaling Pathway Inhibitor 31 2     Dickkopf Homolog 32
Regulated In Glioma1 2     dickkopf-32
REIC2 3     Dickkopf-Related Protein 32
hDkk-32 3     dkk-32
Dickkopf (Xenopus Laevis) Homolog 31     RIG-Like 5-62
Dickkopf 3 Homolog (Xenopus Laevis)1     RIG-Like 7-12
RIG2     Dickkopf-33
Dickkopf 3 Homolog2     Dkk-33

External Ids:    HGNC: 28931   Entrez Gene: 271222   Ensembl: ENSG000000501657   OMIM: 6054165   UniProtKB: Q9UBP43   

Export aliases for DKK3 gene to outside databases

Previous GC identifers: GC11M013255 GC11M012554 GC11M012023 GC11M011948 GC11M011941 GC11M011660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DKK3 Gene:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine
rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.
The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor
suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DKK3 Gene: 
DKK3 (dickkopf WNT signaling pathway inhibitor 3) is a protein-coding gene. Diseases associated with DKK3 include renal clear cell carcinoma, and hepatoblastoma, and among its related super-pathways are Non-Canonical Wnt Pathway.

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
formation and bone disease, cancer and Alzheimer disease (By similarity)

Gene Wiki entry for DKK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DKK3 gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DKK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DKK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

DKK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M011984:  view genomic region     (about GC identifiers)

Start:
11,984,543 bp from pter      End:
12,031,316 bp from pter
Size:
46,774 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4 (See protein sequence)
Recommended Name: Dickkopf-related protein 3 precursor  
Size: 350 amino acids; 38390 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Subcellular location: Secreted
Secondary accessions: A8K1I2 D3DQW1 Q9ULB7

Explore the universe of human proteins at neXtProt for DKK3: NX_Q9UBP4

Explore proteomics data for DKK3 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBP4

  • DKK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DKK3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001018067.1  NP_037385.2  NP_056965.3  

    ENSEMBL proteins: 
     ENSP00000379762   ENSP00000314910   ENSP00000433112   ENSP00000435269   ENSP00000436645  
     ENSP00000431604   ENSP00000398365  

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    Novus Biologicals DKK3 Proteins
    Novus Biologicals DKK3 Lysates
    Sino Biological Recombinant Protein for DKK3
    Sino Biological Cell Lysate for DKK3 
    ProSpec Recombinant Protein for DKK3
    Cloud-Clone Corp. Proteins for DKK3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS10570958

    DKK3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006796 Dickkopf_N

    Graphical View of Domain Structure for InterPro Entry Q9UBP4

    ProtoNet protein and cluster: Q9UBP4

    1 Blocks protein domain: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    DKK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DKK3_HUMAN, Q9UBP4
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
    role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
    patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
    formation and bone disease, cancer and Alzheimer disease (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for DKK3:

     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dkk3):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system 

    DKK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dkk3tm1Cni for DKK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DKK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DKK3

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DKK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Canonical Wnt Pathway
    Canonical Wnt Pathway0.53
    Non-Canonical Wnt Pathway0.53


    2 Sino Biological Pathways for DKK3 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DKK3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for DKK3 (Q9UBP42, 3 ENSP000003149104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=2 STRING: ENSP00000357292
    WNK1Q9H4A33I2D: score=2 
    OPCMLQ149823I2D: score=1 
    IRAK1ENSP000003589974STRING: ENSP00000358997
    --Q777G92MINT-6770041
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0009653anatomical structure morphogenesis TAS10570958
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway ----
    GO:0030325adrenal gland development IEP12844346

    DKK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DKK3

    Search CenterWatch for drugs/clinical trials and news about DKK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DKK3 gene (3 alternative transcripts): 
    NM_001018057.1  NM_013253.4  NM_015881.5  

    Unigene Clusters for DKK3:

    Dickkopf 3 homolog (Xenopus laevis)
    Hs.292156  [show with all ESTs], Hs.731954  [show with all ESTs]
    Unigene Representative Sequences: NM_015881, BG422803
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527132 ENST00000396505(uc001mjv.3) ENST00000326932(uc010rcf.2 uc001mju.3 uc001mjw.3)
    ENST00000525493(uc010rcg.1) ENST00000528188 ENST00000532372 ENST00000525927
    ENST00000532873 ENST00000533813 ENST00000534511 ENST00000529338 ENST00000526218
    ENST00000531309 ENST00000530694 ENST00000534479 ENST00000533900 ENST00000450094


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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate DKK3 (see all 38):
    hsa-miR-300 hsa-let-7d hsa-miR-4272 hsa-miR-25 hsa-miR-3921 hsa-let-7g hsa-miR-3622b-3p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDKK3 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK3
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    Additional mRNA sequence: AF400439.1 

    24 DOTS entries:

    DT.418939  DT.100816741  DT.91767127  DT.40299804  DT.100816739  DT.95156379  DT.97765245  DT.120734819 
    DT.120734800  DT.100819188  DT.120734838  DT.91767118  DT.95156382  DT.120734840  DT.100816735  DT.102824245 
    DT.120734797  DT.120734859  DT.410173  DT.101968117  DT.121627162  DT.92442592  DT.92466268  DT.97779608 

    24/451 AceView cDNA sequences (see all 451):

    BU196968 BU157606 Z38477 BU163369 BM931088 BQ897122 BI335757 BQ888730 
    BG059953 CF132660 BQ688234 BQ687539 BQ686534 AI422538 BM511891 BQ897519 
    CB045352 BQ689791 BQ897670 BQ691090 AA425947 CF131528 BF724383 BQ719036 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DKK3 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a ·
    SP1:                    -     -     -     -     -     -                                         -     -     -           -     -     -     -                     
    SP2:                                            -     -                                         -     -     -           -     -     -     -                     
    SP3:                                      -     -     -                                         -     -     -           -     -     -     -                     
    SP4:                                                                                            -     -     -           -     -     -     -                     
    SP5:                                                                                                                                -     -                     

    ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DKK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DKK3 expression in normal human tissues (normalized intensities)      DKK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTTTGA
    DKK3 Expression
    About this image


    DKK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
             Retina
             sensory organ/eye/cornea   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/atrium   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See DKK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DKK3

    SOURCE GeneReport for Unigene clusters: Hs.292156 Hs.731954

    UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
    Tissue specificity: Highest expression in heart, brain, and spinal cord

        SABiosciences Expression via Pathway-Focused PCR Arrays including DKK3: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DKK3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dkk31 , 5 dickkopf homolog 3 (Xenopus laevis)1, 5 83.96(n)1
    83(a)1
      7 (58.74 cM)5
    507811  NM_015814.21  NP_056629.11 
     1121160195 
    chicken
    (Gallus gallus)
    Aves DKK31 dickkopf homolog 3 (Xenopus laevis) 66.56(n)
    61.26(a)
      396023  NM_205125.1  NP_990456.1 
    lizard
    (Anolis carolinensis)
    Reptilia DKK36
    Uncharacterized protein
    48(a)
    1 ↔ 1
    GL343237.1(547308-588788)
    zebrafish
    (Danio rerio)
    Actinopterygii dkk31 dickkopf homolog 3 (Xenopus laevis) 54.29(n)
    48.57(a)
      100038765  NM_001089545.1  NP_001083014.1 


    ENSEMBL Gene Tree for DKK3 (if available)
    TreeFam Gene Tree for DKK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1090 SNPs in DKK3 are shown (see all 1090)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717201441,2
    C--11909410(+) GTTTA-/CTTTTA
            
    GAGGG
    3 -- ut310--------
    rs1434242581,2
    C--11956379(+) GTAATA/TATTTA 1 -- us2k10--------
    rs125765991,2
    A,H--11956443(+) aagaaA/Ggaaag 1 -- us2k1 trp30--------
    rs1438687401,2
    C--11956447(+) AGGAA-/AGAAAG
    AGAGAAAG
    AGAAA
    1 -- us2k10--------
    rs124202411,2
    C,F,H--11956454(+) AAAGAG/AAGAAA 1 -- us2k1 trp31Minor allele frequency- A:0.50NA 4
    rs595922821,2
    C,F--11956887(+) TCCCAT/CTGTGT 1 -- us2k13Minor allele frequency- C:0.21WA CSA 122
    rs1867814241,2
    --11984132(+) TCACTA/GTAACC 3 -- ds50010--------
    rs1912538101,2
    --11984143(+) TGGACA/GTACTG 3 -- ds50010--------
    rs1436805781,2
    --11984203(+) CTCCAC/TTTGTT 3 -- ds50010--------
    rs1850819571,2
    --11984301(+) CGCAGC/GTGACT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for DKK3 (11984543 - 12031316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DKK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526144CNV Loss19592680
    nsv524257CNV Loss19592680
    nsv832067CNV Gain17160897
    nsv515847CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): DKK3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DKK3
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605416    OMIM disorders: --

    20/34 diseases for DKK3 (see all 34):    About MalaCards
    renal clear cell carcinoma    hepatoblastoma    retinal degeneration    oral cancer
    malignant glioma    lung adenocarcinoma    intrahepatic cholangiocarcinoma    esophageal squamous cell carcinoma
    gastric cancer    cholangiocarcinoma    retinitis    osteosarcoma
    oral squamous cell carcinoma    cervical cancer    neuroblastoma    squamous cell carcinoma
    ovarian cancer    esophagitis    glioblastoma    cervicitis

    1 disease from the University of Copenhagen DISEASES database for DKK3:
    Cancer

    DKK3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for DKK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 41 6 18219095 (2), 20473620 (1), 19570204 (1), 18826564 (1)
    gastric cancer 34.4 11 19051296 (7), 20473620 (1)
    tumors 31.8 21 20473620 (3), 11814687 (3), 19570204 (2), 17549386 (1) (see all 11)
    cancer lung 31.1 6 18048388 (4), 10652205 (1)
    breast cancer 17.3 11 19570204 (4), 18826564 (4)

    Genetic Association Database (GAD): DKK3
    Human Genome Epidemiology (HuGE) Navigator: DKK3 (6 documents)

    Export disorders for DKK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DKK3 gene, integrated from 9 sources (see all 100):
    (articles sorted by number of sources associating them with DKK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3 Krupnik V.E.... McCarthy S.A. (1999)
    2. Reduced expression of the REIC/Dkk-3 gene by promoter- hypermethylation in human tumor cells. (PubMed id 11814687)1, 2, 9 Kobayashi K.... Shimizu K. (2002)
    3. A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. (PubMed id 10652205)1, 2, 9 Tsuji T.... Namba M. (2000)
    4. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 4, 9 Hirata H....Dahiya R. (2009)
    5. Genetic variation of DKK3 may modify renal disease se verity in ADPKD. (PubMed id 20616171)1, 4 Liu M....Pei Y. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27122 HGNC: 2893 AceView: DKK3 Ensembl:ENSG00000050165 euGenes: HUgn27122
    ECgene: DKK3 H-InvDB: DKK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DKK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DKK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DKK3 gene:
    Search GeneIP for patents involving DKK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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