Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DKK3 Gene

protein-coding   GIFtS: 61
GCID: GC11M011984

Dickkopf WNT Signaling Pathway Inhibitor 3

(Previous names: dickkopf (Xenopus laevis) homolog 3, dickkopf 3 homolog...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dickkopf WNT Signaling Pathway Inhibitor 31 2     Dickkopf Homolog 32
Regulated In Glioma1 2     dickkopf-32
REIC2 3     Dickkopf-Related Protein 32
hDkk-32 3     dkk-32
Dickkopf (Xenopus Laevis) Homolog 31     RIG-Like 5-62
Dickkopf 3 Homolog (Xenopus Laevis)1     RIG-Like 7-12
RIG2     Dickkopf-33
Dickkopf 3 Homolog2     Dkk-33

External Ids:    HGNC: 28931   Entrez Gene: 271222   Ensembl: ENSG000000501657   OMIM: 6054165   UniProtKB: Q9UBP43   

Export aliases for DKK3 gene to outside databases

Previous GC identifers: GC11M013255 GC11M012554 GC11M012023 GC11M011948 GC11M011941 GC11M011660


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DKK3 Gene:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine
rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.
The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor
suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DKK3 Gene:
DKK3 (dickkopf WNT signaling pathway inhibitor 3) is a protein-coding gene. Diseases associated with DKK3 include renal clear cell carcinoma, and cervical squamous cell carcinoma.

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
formation and bone disease, cancer and Alzheimer disease (By similarity)

Gene Wiki entry for DKK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DKK3 gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DKK3 promoter sequence
   Search Chromatin IP Primers for DKK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DKK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

DKK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M011984:  view genomic region     (about GC identifiers)

Start:
11,984,543 bp from pter      End:
12,031,316 bp from pter
Size:
46,774 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4 (See protein sequence)
Recommended Name: Dickkopf-related protein 3 precursor  
Size: 350 amino acids; 38390 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Secondary accessions: A8K1I2 D3DQW1 Q9ULB7

Explore the universe of human proteins at neXtProt for DKK3: NX_Q9UBP4

Explore proteomics data for DKK3 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • Glycosylation2 at Thr26, Thr28, Asn96, Asn106, Asn121, Asn204
  • Modification sites at PhosphoSitePlus

  • See DKK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001018067.1  NP_037385.2  NP_056965.3  

    ENSEMBL proteins: 
     ENSP00000379762   ENSP00000314910   ENSP00000433112   ENSP00000435269   ENSP00000436645  
     ENSP00000431604   ENSP00000398365  

    DKK3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DKK3 (Dkk-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for DKK3
    OriGene Protein Over-expression Lysate for DKK3
    OriGene MassSpec for DKK3
    OriGene Custom Protein Services for DKK3
    GenScript Custom Purified and Recombinant Proteins Services for DKK3
    Novus Biologicals DKK3 Proteins
    Novus Biologicals DKK3 Lysates
    Sino Biological Recombinant Protein for DKK3
    Sino Biological Cell Lysate for DKK3
    ProSpec Recombinant Protein for DKK3
    Cloud-Clone Corp. Proteins for DKK3

    DKK3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DKK3 (Dkk-3)
    OriGene Antibodies for DKK3
    OriGene Custom Antibody Services for DKK3
    Novus Biologicals DKK3 Antibodies
    Abcam antibodies for DKK3
    Cloud-Clone Corp. Antibodies for DKK3
    ThermoFisher Antibody for DKK3
    LSBio Antibodies in human, mouse, rat for DKK3

    DKK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DKK3
    R&D Systems ELISAs for DKK3 (Dkk-3)
    GenScript Custom Assay Services for DKK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DKK3
    Cloud-Clone Corp. CLIAs for DKK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR006796 Dickkopf_N

    Graphical View of Domain Structure for InterPro Entry Q9UBP4

    ProtoNet protein and cluster: Q9UBP4

    1 Blocks protein domain: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    DKK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DKK3_HUMAN, Q9UBP4
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
    role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
    patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
    formation and bone disease, cancer and Alzheimer disease (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for DKK3:

     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dkk3):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system 

    DKK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dkk3tm1Cni for DKK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DKK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DKK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DKK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DKK3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DKK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DKK3 (see all 38):
    hsa-miR-300 hsa-let-7d hsa-miR-4272 hsa-miR-25 hsa-miR-3921 hsa-let-7g hsa-miR-3622b-3p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDKK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DKK3
    Predesigned siRNA for gene silencing in human, mouse, rat DKK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DKK3

    Clone
    Products:
         
    OriGene clones in human, mouse for DKK3 (see all 17)
    OriGene ORF clones in mouse, rat for DKK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DKK3 (NM_015881)
    Sino Biological Human cDNA Clone for DKK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DKK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DKK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for DKK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DKK3_HUMAN, Q9UBP4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    plasma membrane3
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS10570958

    DKK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DKK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53


    2 Sino Biological Pathways for DKK3
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including DKK3: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DKK3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for DKK3 (Q9UBP42, 3 ENSP000003149104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR53, ENSP000003572924I2D: score=2 STRING: ENSP00000357292
    WNK1Q9H4A33I2D: score=2 
    OPCMLQ149823I2D: score=1 
    --Q777G92MINT-6770041
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development ----
    GO:0009653anatomical structure morphogenesis TAS10570958
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway ----
    GO:0030325adrenal gland development IEP12844346

    DKK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DKK3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DKK3 gene (3 alternative transcripts): 
    NM_001018057.1  NM_013253.4  NM_015881.5  

    Unigene Cluster for DKK3:

    Dickkopf 3 homolog (Xenopus laevis)
    Hs.292156  [show with all ESTs]
    Unigene Representative Sequence: NM_015881
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527132 ENST00000396505(uc001mjv.3) ENST00000326932(uc010rcf.2 uc001mju.3 uc001mjw.3)
    ENST00000525493(uc010rcg.1) ENST00000528188 ENST00000532372 ENST00000525927
    ENST00000532873 ENST00000533813 ENST00000534511 ENST00000529338 ENST00000526218
    ENST00000531309 ENST00000530694 ENST00000534479 ENST00000533900 ENST00000450094


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DKK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DKK3 (see all 38):
    hsa-miR-300 hsa-let-7d hsa-miR-4272 hsa-miR-25 hsa-miR-3921 hsa-let-7g hsa-miR-3622b-3p hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDKK3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DKK3
    Predesigned siRNA for gene silencing in human, mouse, rat DKK3
    Clone
    Products:
         
    OriGene clones in human, mouse for DKK3 (see all 17)
    OriGene ORF clones in mouse, rat for DKK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DKK3 (NM_015881)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DKK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DKK3
    OriGene qSTAR qPCR primer pairs in human, mouse for DKK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DKK3
      QuantiTect SYBR Green Assays in human, mouse, rat DKK3
      QuantiFast Probe-based Assays in human, mouse, rat DKK3

    Additional mRNA sequence: 

    AB033421.1 AB034203.1 AB057591.1 AF052161.1 AF177396.1 AK092979.1 AK098756.1 AK225156.1 
    AK289897.1 AK295441.1 AK295539.1 AY358378.1 AY587550.1 BC007660.2 U32331.1 

    21 DOTS entries:

    DT.418939  DT.100816741  DT.91767127  DT.40299804  DT.100816739  DT.95156379  DT.97765245  DT.120734819 
    DT.120734800  DT.120734838  DT.91767118  DT.95156382  DT.120734840  DT.100816735  DT.102824245  DT.120734797 
    DT.120734859  DT.410173  DT.101968117  DT.121627162  DT.92466268 

    Selected AceView cDNA sequences (see all 451):

    CD624670 BQ688328 AI954144 BQ690443 BQ723550 AY358378 CK905695 BU191108 
    BQ722575 BU149760 AI620833 NM_015881 BU169116 BQ888956 CD679322 CF132660 
    BQ685185 CB306212 BQ638484 AI055889 BQ690088 AA704905 BQ689483 BQ889489 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DKK3 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a ·
    SP1:                    -     -     -     -     -     -                                         -     -     -           -     -     -     -                     
    SP2:                                            -     -                                         -     -     -           -     -     -     -                     
    SP3:                                      -     -     -                                         -     -     -           -     -     -     -                     
    SP4:                                                                                            -     -     -           -     -     -     -                     
    SP5:                                                                                                                                -     -                     

    ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DKK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DKK3 expression in normal human tissues (normalized intensities)      DKK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTTTGA
    DKK3 Expression
    About this image


    DKK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
             Lens
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    DKK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DKK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292156

    UniProtKB/Swiss-Prot: DKK3_HUMAN, Q9UBP4
    Tissue specificity: Highest expression in heart, brain, and spinal cord

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DKK3: 
              Leukemia in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DKK3
    OriGene qSTAR qPCR primer pairs in human, mouse for DKK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DKK3
    QuantiTect SYBR Green Assays in human, mouse, rat DKK3
    QuantiFast Probe-based Assays in human, mouse, rat DKK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DKK3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dkk31 , 5 dickkopf homolog 3 (Xenopus laevis)1, 5 84.81(n)1
    83.54(a)1
      7 (58.74 cM)5
    507811  NM_015814.21  NP_056629.11 
     1121160195 
    chicken
    (Gallus gallus)
    Aves DKK31 dickkopf homolog 3 (Xenopus laevis) 66.56(n)
    61.26(a)
      396023  NM_205125.1  NP_990456.1 
    lizard
    (Anolis carolinensis)
    Reptilia DKK36
    dickkopf WNT signaling pathway inhibitor 3
    48(a)
    1 ↔ 1
    GL343237.1(547308-588788)
    zebrafish
    (Danio rerio)
    Actinopterygii dkk31 dickkopf homolog 3 (Xenopus laevis) 54.01(n)
    48.57(a)
      100038765  NM_001089545.1  NP_001083014.1 


    ENSEMBL Gene Tree for DKK3 (if available)
    TreeFam Gene Tree for DKK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DKK3 (see all 1090)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717201441,2
    C--11909410(+) GTTTA-/CTTTTA
            
    GAGGG
    3 -- ut310--------
    rs1434242581,2
    C--11956379(+) GTAATA/TATTTA 1 -- us2k10--------
    rs125765991,2
    A,H--11956443(+) aagaaA/Ggaaag 1 -- us2k1 trp30--------
    rs1438687401,2
    C--11956447(+) AGGAA-/AGAAAG
    AGAGAAAG
    AGAAA
    1 -- us2k10--------
    rs124202411,2
    C,F,H--11956454(+) AAAGAG/AAGAAA 1 -- us2k1 trp31Minor allele frequency- A:0.50NA 4
    rs595922821,2
    C,F--11956887(+) TCCCAT/CTGTGT 1 -- us2k13Minor allele frequency- C:0.21WA CSA 122
    rs1867814241,2
    --11984132(+) TCACTA/GTAACC 3 -- ds50010--------
    rs1912538101,2
    --11984143(+) TGGACA/GTACTG 3 -- ds50010--------
    rs1436805781,2
    --11984203(+) CTCCAC/TTTGTT 3 -- ds50010--------
    rs1850819571,2
    --11984301(+) CGCAGC/GTGACT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for DKK3 (11984543 - 12031316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DKK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526144CNV Loss19592680
    nsv524257CNV Loss19592680
    nsv832067CNV Gain17160897
    nsv515847CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): DKK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DKK3
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605416    OMIM disorders: --

    Selected diseases for DKK3 (see all 36):    About MalaCards
    renal clear cell carcinoma    cervical squamous cell carcinoma    hepatoblastoma    retinal degeneration
    oral cancer    malignant glioma    pancreatic ductal adenocarcinoma    squamous cell carcinoma
    intrahepatic cholangiocarcinoma    lung adenocarcinoma    cholangiocarcinoma    oral squamous cell carcinoma
    esophageal squamous cell carcinoma    bronchiolitis    retinitis    osteosarcoma
    neuroblastoma    cervical cancer    cervicitis    esophagitis

    1 disease from the University of Copenhagen DISEASES database for DKK3:
    Cancer

    DKK3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for DKK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 41 6 18219095 (2), 20473620 (1), 19570204 (1), 18826564 (1)
    gastric cancer 34.4 11 19051296 (7), 20473620 (1)
    tumors 31.8 21 20473620 (3), 11814687 (3), 19570204 (2), 17549386 (1) (see all 11)
    cancer lung 31.1 6 18048388 (4), 10652205 (1)
    breast cancer 17.3 11 19570204 (4), 18826564 (4)

    Genetic Association Database (GAD): DKK3
    Human Genome Epidemiology (HuGE) Navigator: DKK3 (6 documents)

    Export disorders for DKK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DKK3 gene, integrated from 10 sources (see all 103):
    (articles sorted by number of sources associating them with DKK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3 Krupnik V.E.... McCarthy S.A. (Gene 1999)
    2. Reduced expression of the REIC/Dkk-3 gene by promoter- hypermethylation in human tumor cells. (PubMed id 11814687)1, 2, 9 Kobayashi K.... Shimizu K. (Gene 2002)
    3. A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. (PubMed id 10652205)1, 2, 9 Tsuji T.... Namba M. (Biochem. Biophys. Res. Commun. 2000)
    4. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 4, 9 Hirata H....Dahiya R. (Cancer 2009)
    5. Genetic variation of DKK3 may modify renal disease severity in ADPKD. (PubMed id 20616171)1, 4 Liu M....Pei Y. (J. Am. Soc. Nephrol. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27122 HGNC: 2893 AceView: DKK3 Ensembl:ENSG00000050165 euGenes: HUgn27122
    ECgene: DKK3 H-InvDB: DKK3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DKK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DKK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DKK3 gene:
    Search GeneIP for patents involving DKK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for DKK3 (Dkk-3)   Browse Cell Culture Products  
     ELISAs for DKK3 (Dkk-3)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for DKK3 (Dkk-3)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DKK3   OriGene RNAi products in human, mouse, rat for DKK3  
     OriGene qPCR primer pairs and template standards for DKK3   OriGene Protein Over-expression Lysate for DKK3  
     OriGene MassSpec something-or-other for DKK3   OriGene clones in human, mouse for DKK3  
     OriGene qSTAR qPCR primer pairs in human, mouse for DKK3   OriGene Purified Protein for DKK3  
     OriGene ORF clones in mouse, rat for DKK3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DKK3   OriGene Custom Protein Services for DKK3  

     
     
     Block miRNA regulation of human, mouse, rat DKK3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DKK3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DKK3 Predesigned siRNA for gene silencing in human, mouse, rat DKK3
     QuantiFast Probe-based Assays in human, mouse, rat DKK3 QuantiTect SYBR Green Assays in human, mouse, rat DKK3
     PCR Arrays including human, mouse, rat DKK3 Search Chromatin IP Primers for DKK3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DKK3  GeneGlobe Interaction Network for DKK3
     Regulatory tfbs in DKK3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DKK3 GenScript cDNA clones with any tag delivered in your preferred vector for DKK3
     GenScript Custom Assay Services for DKK3 GenScript Custom overexpressing Cell Line Services for DKK3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DKK3
     Proteins for DKK3
     Cell Lysates for DKK3
     cDNA Clones for DKK3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DKK3 antibodies
     DKK3 proteins
     DKK3 lysates
     Antibodies for DKK3
     See all of Abcam's Antibodies, Kits and Proteins for DKK3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DKK3
     Proteins for DKK3
     Antibodies for DKK3
     ELISAs for DKK3
     CLIAs for DKK3



     Browse ESI BIO Cell Lines and PureStem Progenitors for DKK3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK3
     SwitchGear 3'UTR luciferase reporter plasmids for DKK3
     SwitchGear Promoter luciferase reporter plasmids for DKK3
     ThermoFisher Antibody for DKK3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DKK3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DKK3
     LSBio Antibodies in human, mouse, rat for DKK3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DKK3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4