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Aliases for DKK3 Gene

Aliases for DKK3 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 3 2 3
  • Regulated In Glioma 2 3
  • Dickkopf-3 3 4
  • HDkk-3 3 4
  • Dkk-3 3 4
  • REIC 3 4
  • Dickkopf (Xenopus Laevis) Homolog 3 2
  • Dickkopf 3 Homolog (Xenopus Laevis) 2
  • Dickkopf-Related Protein 3 3
  • Dickkopf 3 Homolog 3
  • Dickkopf Homolog 3 3
  • RIG-Like 5-6 3
  • RIG-Like 7-1 3
  • RIG 3

External Ids for DKK3 Gene

Summaries for DKK3 Gene

Entrez Gene Summary for DKK3 Gene

  • This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK3 Gene

DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3) is a Protein Coding gene. Among its related pathways are Non-Canonical Wnt Pathway and Non-Canonical Wnt Pathway.

UniProtKB/Swiss-Prot for DKK3 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Gene Wiki entry for DKK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK3 Gene

Genomics for DKK3 Gene

Genomic Location for DKK3 Gene

Start:
11,962,996 bp from pter
End:
12,009,826 bp from pter
Size:
46,831 bases
Orientation:
Minus strand

Genomic View for DKK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DKK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK3 Gene

Regulatory Elements for DKK3 Gene

Transcription factor binding sites by QIAGEN in the DKK3 gene promoter:

Proteins for DKK3 Gene

  • Protein details for DKK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBP4-DKK3_HUMAN
    Recommended name:
    Dickkopf-related protein 3
    Protein Accession:
    Q9UBP4
    Secondary Accessions:
    • A8K1I2
    • D3DQW1
    • Q9ULB7

    Protein attributes for DKK3 Gene

    Size:
    350 amino acids
    Molecular mass:
    38390 Da
    Quaternary structure:
    • Interacts with LRP5 and LRP6.

neXtProt entry for DKK3 Gene

Proteomics data for DKK3 Gene at MOPED

Post-translational modifications for DKK3 Gene

  • N- and O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr26, Thr28, Asn96, Asn106, Asn121, and Asn204

Other Protein References for DKK3 Gene

No data available for DME Specific Peptides for DKK3 Gene

Domains for DKK3 Gene

Protein Domains for DKK3 Gene

UniProtKB/Swiss-Prot:

DKK3_HUMAN
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.:
    • Q9UBP4
Family:
  • Belongs to the dickkopf family.:
    • Q9UBP4
genes like me logo Genes that share domains with DKK3: view

No data available for Gene Families for DKK3 Gene

Function for DKK3 Gene

Molecular function for DKK3 Gene

UniProtKB/Swiss-Prot Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
genes like me logo Genes that share phenotypes with DKK3: view

Animal Models for DKK3 Gene

MGI Knock Outs for DKK3:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for DKK3 Gene

Localization for DKK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DKK3 Gene COMPARTMENTS Subcellular localization image for DKK3 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DKK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space TAS 10570958
genes like me logo Genes that share ontologies with DKK3: view

Pathways for DKK3 Gene

genes like me logo Genes that share pathways with DKK3: view

Pathways by source for DKK3 Gene

2 Sino Biological pathways for DKK3 Gene

Interacting Proteins for DKK3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314910%0d%0a9606.ENSP00000357292%0d%0a
Selected Interacting proteins: Q9UBP4-DKK3_HUMAN ENSP00000314910 for DKK3 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for DKK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development --
GO:0009653 anatomical structure morphogenesis TAS 10570958
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway --
GO:0030325 adrenal gland development IEP 12844346
genes like me logo Genes that share ontologies with DKK3: view

Transcripts for DKK3 Gene

Unigene Clusters for DKK3 Gene

Dickkopf 3 homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DKK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - - -
SP9: -
SP10: - - - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - -
SP14:
SP15:
SP16: - - - - - - - - - - - - - - -
SP17: - - -

ExUns: 13b · 13c ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - -
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - -
SP17:

Relevant External Links for DKK3 Gene

GeneLoc Exon Structure for
DKK3
ECgene alternative splicing isoforms for
DKK3

Expression for DKK3 Gene

mRNA expression in normal human tissues for DKK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DKK3 Gene

This gene is overexpressed in Heart - Atrial Appendage (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DKK3 Gene

SOURCE GeneReport for Unigene cluster for DKK3 Gene Hs.292156

mRNA Expression by UniProt/SwissProt for DKK3 Gene

Q9UBP4-DKK3_HUMAN
Tissue specificity: Highest expression in heart, brain, and spinal cord.
genes like me logo Genes that share expressions with DKK3: view

Orthologs for DKK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DKK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKK3 36
  • 99.05 (n)
  • 98.29 (a)
DKK3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DKK3 36
  • 88.83 (n)
  • 87.97 (a)
DKK3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DKK3 36
  • 88.09 (n)
  • 85.3 (a)
DKK3 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dkk3 36
  • 84.81 (n)
  • 83.54 (a)
Dkk3 16
Dkk3 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DKK3 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DKK3 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dkk3 36
  • 83.18 (n)
  • 80.13 (a)
chicken
(Gallus gallus)
Aves DKK3 36
  • 66.56 (n)
  • 61.26 (a)
DKK3 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DKK3 37
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13938 36
zebrafish
(Danio rerio)
Actinopterygii dkk3 36
  • 54.01 (n)
  • 48.57 (a)
dkk3a 37
  • 37 (a)
OneToMany
dkk3b 37
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.181 37
  • 18 (a)
OneToOne
Species with no ortholog for DKK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DKK3 Gene

ENSEMBL:
Gene Tree for DKK3 (if available)
TreeFam:
Gene Tree for DKK3 (if available)

Paralogs for DKK3 Gene

No data available for Paralogs for DKK3 Gene

Variants for DKK3 Gene

Sequence variations from dbSNP and Humsavar for DKK3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8169 -- 11,963,307(+) GCATA(A/T)TACAA utr-variant-3-prime
rs751580 -- 12,004,403(-) AGACC(C/T)AATTC intron-variant
rs903014 -- 11,999,177(+) CATCT(C/T)TCATG intron-variant
rs911640 -- 12,003,748(+) TTTTT(A/T)AAAAA intron-variant
rs952932 -- 11,994,981(-) GTGGT(A/G)GCTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DKK3 Gene

Variant ID Type Subtype PubMed ID
nsv832067 CNV Gain 17160897
nsv524257 CNV Loss 19592680
nsv526144 CNV Loss 19592680
nsv515847 CNV Gain+Loss 19592680

Relevant External Links for DKK3 Gene

HapMap Linkage Disequilibrium report
DKK3
Human Gene Mutation Database (HGMD)
DKK3

Disorders for DKK3 Gene

(1) University of Copenhagen DISEASES for DKK3 Gene

(5) Novoseek inferred disease relationships for DKK3 Gene

Disease -log(P) Hits PubMed IDs
cancer 41 5
gastric cancer 34.4 8
tumors 31.8 16
cancer lung 31.1 5
breast cancer 17.3 8

Relevant External Links for DKK3

Genetic Association Database (GAD)
DKK3
Human Genome Epidemiology (HuGE) Navigator
DKK3
genes like me logo Genes that share disorders with DKK3: view

No data available for UniProtKB/Swiss-Prot for DKK3 Gene

Publications for DKK3 Gene

  1. A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. (PMID: 10652205) Tsuji T. … Namba M. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Reduced expression of the REIC/Dkk-3 gene by promoter- hypermethylation in human tumor cells. (PMID: 11814687) Kobayashi K. … Shimizu K. (Gene 2002) 3 4 23
  3. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H. … Dahiya R. (Cancer 2009) 3 23 49
  4. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for DKK3 Gene

  • Addgene plasmids for DKK3

Sources for DKK3 Gene

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