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Aliases for DKK2 Gene

Aliases for DKK2 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 2 2 3
  • Dickkopf-2 3 4
  • HDkk-2 3 4
  • DKK-2 3 4
  • Dickkopf (Xenopus Laevis) Homolog 2 2
  • Dickkopf 2 Homolog (Xenopus Laevis) 2
  • Dickkopf Related Protein-2 3
  • Dickkopf-Related Protein 2 3
  • Dickkopf 2 Homolog 3
  • Dickkopf Homolog 2 3

External Ids for DKK2 Gene

Summaries for DKK2 Gene

Entrez Gene Summary for DKK2 Gene

  • This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK2 Gene

DKK2 (Dickkopf WNT Signaling Pathway Inhibitor 2) is a Protein Coding gene. Among its related pathways are Wnt / Hedgehog / Notch and Wnt signaling pathway (KEGG). An important paralog of this gene is DKK1.

UniProtKB/Swiss-Prot for DKK2 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Gene Wiki entry for DKK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK2 Gene

Genomics for DKK2 Gene

Genomic Location for DKK2 Gene

Start:
106,921,802 bp from pter
End:
107,283,806 bp from pter
Size:
362,005 bases
Orientation:
Minus strand

Genomic View for DKK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DKK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK2 Gene

Regulatory Elements for DKK2 Gene

Proteins for DKK2 Gene

  • Protein details for DKK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU2-DKK2_HUMAN
    Recommended name:
    Dickkopf-related protein 2
    Protein Accession:
    Q9UBU2
    Secondary Accessions:
    • A0AVE9
    • B2R6S7
    • Q9UIU3

    Protein attributes for DKK2 Gene

    Size:
    259 amino acids
    Molecular mass:
    28447 Da
    Quaternary structure:
    • Interacts with LRP5 and LRP6.

neXtProt entry for DKK2 Gene

Proteomics data for DKK2 Gene at MOPED

Post-translational modifications for DKK2 Gene

Other Protein References for DKK2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DKK2 Gene

Domains for DKK2 Gene

Protein Domains for DKK2 Gene

UniProtKB/Swiss-Prot:

DKK2_HUMAN
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.:
    • Q9UBU2
Family:
  • Belongs to the dickkopf family.:
    • Q9UBU2
genes like me logo Genes that share domains with DKK2: view

No data available for Gene Families for DKK2 Gene

Function for DKK2 Gene

Molecular function for DKK2 Gene

UniProtKB/Swiss-Prot Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Gene Ontology (GO) - Molecular Function for DKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity --
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with DKK2: view
genes like me logo Genes that share phenotypes with DKK2: view

Animal Models for DKK2 Gene

MGI Knock Outs for DKK2:

miRNA for DKK2 Gene

miRTarBase miRNAs that target DKK2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DKK2 Gene

Localization for DKK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DKK2 Gene COMPARTMENTS Subcellular localization image for DKK2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 11742004
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with DKK2: view

Pathways for DKK2 Gene

genes like me logo Genes that share pathways with DKK2: view

Pathways by source for DKK2 Gene

2 Sino Biological pathways for DKK2 Gene
2 Qiagen pathways for DKK2 Gene
1 Cell Signaling Technology pathway for DKK2 Gene
1 BioSystems pathway for DKK2 Gene
1 KEGG pathway for DKK2 Gene

Gene Ontology (GO) - Biological Process for DKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0007275 multicellular organismal development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway --
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 11742004
genes like me logo Genes that share ontologies with DKK2: view

Transcripts for DKK2 Gene

Unigene Clusters for DKK2 Gene

Dickkopf 2 homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DKK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for DKK2 Gene

GeneLoc Exon Structure for
DKK2
ECgene alternative splicing isoforms for
DKK2

Expression for DKK2 Gene

mRNA expression in normal human tissues for DKK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DKK2 Gene

This gene is overexpressed in Nerve - Tibial (4.9) and Lung (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DKK2 Gene

SOURCE GeneReport for Unigene cluster for DKK2 Gene Hs.211869

mRNA Expression by UniProt/SwissProt for DKK2 Gene

Q9UBU2-DKK2_HUMAN
Tissue specificity: Expressed in heart, brain, skeletal muscle and lung
genes like me logo Genes that share expressions with DKK2: view

Orthologs for DKK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DKK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKK2 36
  • 98.97 (n)
  • 98.46 (a)
DKK2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DKK2 36
  • 91.38 (n)
  • 95.75 (a)
DKK2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DKK2 36
  • 91.89 (n)
  • 95.75 (a)
DKK2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dkk2 36
  • 89.58 (n)
  • 95.37 (a)
Dkk2 16
Dkk2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DKK2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DKK2 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dkk2 36
  • 89.32 (n)
  • 95.75 (a)
chicken
(Gallus gallus)
Aves DKK2 36
  • 76.21 (n)
  • 81.62 (a)
DKK2 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DKK2 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dkk2-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dkk2 36
  • 71.16 (n)
  • 75.65 (a)
zebrafish
(Danio rerio)
Actinopterygii dkk2 36
  • 67.91 (n)
  • 66.36 (a)
dkk2 37
  • 57 (a)
OneToOne
Species with no ortholog for DKK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DKK2 Gene

ENSEMBL:
Gene Tree for DKK2 (if available)
TreeFam:
Gene Tree for DKK2 (if available)

Paralogs for DKK2 Gene

Paralogs for DKK2 Gene

Selected SIMAP similar genes for DKK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DKK2: view

Variants for DKK2 Gene

Sequence variations from dbSNP and Humsavar for DKK2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs368279 -- 106,958,256(+) AGTCA(A/C)TCTTT intron-variant
rs374550 -- 106,943,492(+) AGTTG(A/C)CTTTG intron-variant
rs374583 -- 106,943,529(+) ATTGA(A/G)GTCCT intron-variant
rs386203 -- 106,943,490(+) AGAGT(G/T)GCCTT intron-variant
rs386238 -- 106,943,526(+) AAAAT(G/T)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DKK2 Gene

Variant ID Type Subtype PubMed ID
esv2752020 CNV Gain 17911159
nsv4453 CNV Insertion 18451855
nsv879709 CNV Loss 21882294
esv2728109 CNV Deletion 23290073

Relevant External Links for DKK2 Gene

HapMap Linkage Disequilibrium report
DKK2
Human Gene Mutation Database (HGMD)
DKK2

Disorders for DKK2 Gene

Relevant External Links for DKK2

Genetic Association Database (GAD)
DKK2
Human Genome Epidemiology (HuGE) Navigator
DKK2
genes like me logo Genes that share disorders with DKK2: view

No data available for UniProtKB/Swiss-Prot for DKK2 Gene

Publications for DKK2 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. (PMID: 11137016) Wu W. … Niehrs C. (Curr. Biol. 2000) 3 23
  5. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. (PMID: 11742004) Li L. … Wu D. (J. Biol. Chem. 2002) 3 23

Products for DKK2 Gene

  • Addgene plasmids for DKK2

Sources for DKK2 Gene

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