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DKK2 Gene

protein-coding   GIFtS: 64
GCID: GC04M107842

Dickkopf WNT Signaling Pathway Inhibitor 2

(Previous names: dickkopf (Xenopus laevis) homolog 2, dickkopf 2 homolog...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dickkopf WNT Signaling Pathway Inhibitor 21 2     Dickkopf Homolog 22
hDkk-22 3     Dickkopf Related Protein-22
Dickkopf (Xenopus Laevis) Homolog 21     dickkopf-22
Dickkopf 2 Homolog (Xenopus Laevis)1     Dickkopf-Related Protein 22
DKK-22     Dickkopf-23
Dickkopf 2 Homolog2     Dkk-23

External Ids:    HGNC: 28921   Entrez Gene: 271232   Ensembl: ENSG000001550117   OMIM: 6054155   UniProtKB: Q9UBU23   

Export aliases for DKK2 gene to outside databases

Previous GC identifers: GC04M108253 GC04M108301 GC04M108200 GC04M108062 GC04M103577


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DKK2 Gene:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine
rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It
can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and
the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt
co-receptor LDL-receptor related protein 6 (LRP6). (provided by RefSeq, Jul 2008)

GeneCards Summary for DKK2 Gene:
DKK2 (dickkopf WNT signaling pathway inhibitor 2) is a protein-coding gene. An important paralog of this gene is DKK4.

UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
formation and bone disease, cancer and Alzheimer disease (By similarity)

Gene Wiki entry for DKK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DKK2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   RORalpha2   GATA-2   C/EBPalpha   FOXC1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DKK2 promoter sequence
   Search Chromatin IP Primers for DKK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DKK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

DKK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M107842:  view genomic region     (about GC identifiers)

Start:
107,842,959 bp from pter      End:
108,204,963 bp from pter
Size:
362,005 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2 (See protein sequence)
Recommended Name: Dickkopf-related protein 2 precursor  
Size: 259 amino acids; 28447 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Secondary accessions: A0AVE9 B2R6S7 Q9UIU3

Explore the universe of human proteins at neXtProt for DKK2: NX_Q9UBU2

Explore proteomics data for DKK2 at MOPED

Post-translational modifications: 

  • May be proteolytically processed by a furin-like protease1
  • Glycosylation2 at Asn52

  • See DKK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055236.1  
    ENSEMBL proteins: 
     ENSP00000285311   ENSP00000421255   ENSP00000423797  
    Reactome Protein details: Q9UBU2

    DKK2 Human Recombinant Protein Products:

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    antibodies-online proteins for DKK2 (7 products) 

     
    antibodies-online peptides for DKK2

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    antibodies-online kits for DKK2 (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006796 Dickkopf_N

    Graphical View of Domain Structure for InterPro Entry Q9UBU2

    ProtoNet protein and cluster: Q9UBU2

    1 Blocks protein domain: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    Find genes that share domains with DKK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DKK2_HUMAN, Q9UBU2
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
    role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
    patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
    formation and bone disease, cancer and Alzheimer disease (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ----
    GO:0008270zinc ion binding ----
         
    Find genes that share ontologies with DKK2           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dkk2):
     cellular  growth/size/body  hematopoietic system  immune system  skeleton 
     vision/eye 

    Find genes that share phenotypes with DKK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DKK2: Dkk2tm1Lmgd Dkk2tm1Dwu

       genOway: Develop your customized and physiologically relevant rodent model for DKK2

    miRNA
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    miRTarBase miRNAs that target DKK2:
    hsa-mir-335-5p (MIRT018639), hsa-mir-218-5p (MIRT007048), hsa-mir-221-3p (MIRT003362)

    Block miRNA regulation of human, mouse, rat DKK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DKK2 (see all 41):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-218 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidDKK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DKK2

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    Addgene plasmids for DKK2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DKK2_HUMAN, Q9UBU2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA11742004
    GO:0005634nucleus ----

    Find genes that share ontologies with DKK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DKK2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    3WNT Signaling
    WNT Signaling
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)


    Find genes that share SuperPaths with DKK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DKK2
        Reelin Pathway (Cajal-Retzius cells)
    WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for DKK2
        Wnt / Hedgehog / Notch

    1 BioSystems Pathway for DKK2
        Presenilin action in Notch and Wnt signaling

    2 Sino Biological Pathways for DKK2
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2 Reactome Pathways for DKK2
        negative regulation of TCF-dependent signaling by WNT ligand antagonists
    TCF dependent signaling in response to WNT


    1 Kegg Pathway  (Kegg details for DKK2):
        Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including DKK2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DKK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for DKK2 (Q9UBU23 ENSP000002853114) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP6O755813, ENSP000002613494I2D: score=1 STRING: ENSP00000261349
    DKK1ENSP000003630814STRING: ENSP00000363081
    KREMEN2ENSP000003044224STRING: ENSP00000304422
    LRP5ENSP000002943044STRING: ENSP00000294304
    SFRP1ENSP000002207724STRING: ENSP00000220772
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway ----
    GO:0090090negative regulation of canonical Wnt signaling pathway IDA11742004

    Find genes that share ontologies with DKK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DKK2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DKK2 gene: 
    NM_014421.2  

    Unigene Cluster for DKK2:

    Dickkopf 2 homolog (Xenopus laevis)
    Hs.211869  [show with all ESTs]
    Unigene Representative Sequence: AF177395
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285311(uc003hyi.3 uc003hyj.1) ENST00000513208(uc010ilw.1)
    ENST00000510534 ENST00000510463
    miRNA
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    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-218 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidDKK2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DKK2
      QuantiFast Probe-based Assays in human, mouse, rat DKK2

    Additional mRNA sequence: 

    AB033208.1 AF177395.1 AK309466.1 AK312695.1 AY358414.1 BC075077.2 BC075078.2 BC126328.1 
    BC126330.1 

    2 DOTS entries:

    DT.407612  DT.92418105 

    Selected AceView cDNA sequences (see all 29):

    BC075078 AI863392 AI093106 BC075077 BQ959276 BX646253 AW316551 AI184289 
    AB033941 AY358414 AA720544 AB033208 BQ011814 AI333962 BU902436 AA481794 
    BQ023032 NM_014421 AA300480 AF177395 AW022313 W55979 AA648103 AI370632 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DKK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for DKK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DKK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTTGCTA
    DKK2 Expression
    About this image


    DKK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Periocular Mesenchymal Cells Periocular Mesenchyme
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Endothelium (Cardiovascular System)
             Periocular Mesenchymal Cells Periocular Mesenchyme
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Maxillary Process
             HyStem+BMP4-induced SK11 cells
    DKK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DKK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211869

    UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2
    Tissue specificity: Expressed in heart, brain, skeletal muscle and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including DKK2: 
              Polycomb & Trithorax Target Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DKK2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dkk21 , 5 dickkopf homolog 2 (Xenopus laevis)1, 5 89.58(n)1
    95.37(a)1
      3 (61.32 cM)5
    568111  NM_020265.41  NP_064661.21 
     1320852925 
    chicken
    (Gallus gallus)
    Aves DKK21 dickkopf 2 homolog (Xenopus laevis) 76.21(n)
    81.62(a)
      422531  XM_420494.4  XP_420494.1 
    lizard
    (Anolis carolinensis)
    Reptilia DKK26
    dickkopf WNT signaling pathway inhibitor 2
    69(a)
    1 ↔ 1
    GL343384.1(699686-770007)
    African clawed frog
    (Xenopus laevis)
    Amphibia dkk2-A2 dickkopf homolog 2 77.03(n)    AJ300197.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dkk21 dickkopf homolog 2 (Xenopus laevis) 67.91(n)
    66.36(a)
      792404  NM_001111209.1  NP_001104679.1 


    ENSEMBL Gene Tree for DKK2 (if available)
    TreeFam Gene Tree for DKK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DKK2 gene
    DKK42  DKK12  
    2 SIMAP similar genes for DKK2 using alignment to 4 protein entries:     DKK2_HUMAN (see all proteins):
    DKK1    DKK4

    Find genes that share paralogs with DKK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DKK2 (see all 2232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709470521,2
    C--103621098(+) AGATA-/GATT  
            
    GATTG
    1 -- int11Minor allele frequency- GATT:0.00NA 2
    rs353333011,2
    C--107729057(+) GTCTC-/AAAAAA 1 -- int10--------
    rs570770271,2
    C,F--107842512(+) GTATCG/ATGTAG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs790092461,2
    C,F--107842531(+) CATTGG/ATTCAT 1 -- ds50011Minor allele frequency- A:0.07NA 120
    rs1426857921,2
    --107842561(+) CTAAGA/CATAAT 1 -- ds50010--------
    rs1868748331,2
    --107842625(+) TTACCG/TGTCTT 1 -- ds50010--------
    rs284523071,2
    C,F--107842724(+) GCTGGA/CATATT 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs286815521,2
    C,F--107842733(+) TTTTGG/ATTTGG 1 -- ds50013Minor allele frequency- A:0.05NA CSA WA 122
    rs4020021,2
    C,F,H--107842734(+) TTTGGT/CTTGGA 1 -- ds50019Minor allele frequency- C:0.32NS EA NA WA 664
    rs1121675051,2
    C,F--107842917(+) GATTCC/TATGAA 1 -- ds50011Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for DKK2 (107842959 - 108092959 bp, first 250kb of DKK2)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DKK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728109CNV Deletion23290073
    nsv4453CNV Insertion18451855
    nsv879709CNV Loss21882294
    esv2752020CNV Gain17911159

    Human Gene Mutation Database (HGMD): DKK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DKK2
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605415    OMIM disorders: --


    Find genes that share disorders with DKK2           About GenesLikeMe

    Genetic Association Database (GAD): DKK2
    Human Genome Epidemiology (HuGE) Navigator: DKK2 (6 documents)

    Export disorders for DKK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DKK2 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with DKK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3 Krupnik V.E.... McCarthy S.A. (Gene 1999)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 4 Hirata H....Dahiya R. (Cancer 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces. (PubMed id 20004015)1, 9 Olivares-Navarrete R....Schwartz Z. (Biomaterials 2010)
    9. EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. (PubMed id 19247449)1, 9 Miyagawa Y....Kiyokawa N. (PLoS ONE 2009)
    10. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. (PubMed id 11742004)1, 9 Li L....Wu D. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27123 HGNC: 2892 AceView: DKK2 Ensembl:ENSG00000155011 euGenes: HUgn27123
    ECgene: DKK2 Kegg: 27123 H-InvDB: DKK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DKK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DKK2 gene:
    Search GeneIP for patents involving DKK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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