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Aliases for DKK2 Gene

Aliases for DKK2 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 2 2 3 5
  • Dickkopf-2 3 4
  • HDkk-2 3 4
  • DKK-2 3 4
  • Dickkopf (Xenopus Laevis) Homolog 2 2
  • Dickkopf 2 Homolog (Xenopus Laevis) 2
  • Dickkopf-Related Protein 2 3
  • Dickkopf 2 Homolog 3
  • Dickkopf Homolog 2 3

External Ids for DKK2 Gene

Previous GeneCards Identifiers for DKK2 Gene

  • GC04M108253
  • GC04M108301
  • GC04M108200
  • GC04M108062
  • GC04M107842
  • GC04M103577

Summaries for DKK2 Gene

Entrez Gene Summary for DKK2 Gene

  • This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK2 Gene

DKK2 (Dickkopf WNT Signaling Pathway Inhibitor 2) is a Protein Coding gene. Diseases associated with DKK2 include Apocrine Sweat Gland Neoplasm. Among its related pathways are Signaling by Wnt and HIV Life Cycle. GO annotations related to this gene include RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is DKK1.

UniProtKB/Swiss-Prot for DKK2 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Gene Wiki entry for DKK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK2 Gene

Genomics for DKK2 Gene

Regulatory Elements for DKK2 Gene

Enhancers for DKK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G107033 1.3 FANTOM5 Ensembl ENCODE 19.3 +249.5 249505 1.1 CTCF PKNOX1 ZNF654 MXI1 SIN3A REST RAD21 ZNF664 ZNF366 PATZ1 DKK2 GC04P106971 VN1R22P
GH04G107027 0.4 FANTOM5 30.6 +256.3 256330 0.5 SCRT2 DKK2 GC04P106971 VN1R22P
GH04G107213 0.6 ENCODE 10.5 +70.2 70238 0.2 CTCF JUND POLR2A SMARCA4 SIN3A RAD21 DKK2 RAC1P5 LOC102725220
GH04G107028 0.4 FANTOM5 5.2 +255.5 255455 0.1 ATF2 DKK2 GC04P106971 VN1R22P
GH04G107279 0.9 Ensembl ENCODE 0.7 +3.9 3865 0.5 FOXA2 JUN FOXA1 JUND GATA3 CTBP1 FOSL2 FOS EZH2 DKK2 LOC102725220
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DKK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DKK2 Gene

Chromosome:
4
Start:
106,921,802 bp from pter
End:
107,283,806 bp from pter
Size:
362,005 bases
Orientation:
Minus strand

Genomic View for DKK2 Gene

Genes around DKK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK2 Gene

Proteins for DKK2 Gene

  • Protein details for DKK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU2-DKK2_HUMAN
    Recommended name:
    Dickkopf-related protein 2
    Protein Accession:
    Q9UBU2
    Secondary Accessions:
    • A0AVE9
    • B2R6S7
    • Q9UIU3

    Protein attributes for DKK2 Gene

    Size:
    259 amino acids
    Molecular mass:
    28447 Da
    Quaternary structure:
    • Interacts with LRP5 and LRP6.

neXtProt entry for DKK2 Gene

Post-translational modifications for DKK2 Gene

Other Protein References for DKK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DKK2 (DKK2)
  • Abcam antibodies for DKK2

No data available for DME Specific Peptides for DKK2 Gene

Domains & Families for DKK2 Gene

Protein Domains for DKK2 Gene

Suggested Antigen Peptide Sequences for DKK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBU2

UniProtKB/Swiss-Prot:

DKK2_HUMAN :
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Belongs to the dickkopf family.
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Family:
  • Belongs to the dickkopf family.
genes like me logo Genes that share domains with DKK2: view

No data available for Gene Families for DKK2 Gene

Function for DKK2 Gene

Molecular function for DKK2 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Gene Ontology (GO) - Molecular Function for DKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0039706 co-receptor binding IEA --
genes like me logo Genes that share ontologies with DKK2: view
genes like me logo Genes that share phenotypes with DKK2: view

Animal Models for DKK2 Gene

MGI Knock Outs for DKK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for DKK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DKK2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DKK2 Gene

Localization for DKK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DKK2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for DKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 11742004
genes like me logo Genes that share ontologies with DKK2: view

Pathways & Interactions for DKK2 Gene

genes like me logo Genes that share pathways with DKK2: view

Pathways by source for DKK2 Gene

1 Sino Biological pathway for DKK2 Gene
1 GeneTex pathway for DKK2 Gene
1 Cell Signaling Technology pathway for DKK2 Gene
1 BioSystems pathway for DKK2 Gene

Gene Ontology (GO) - Biological Process for DKK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway NAS 24431302
GO:0090263 positive regulation of canonical Wnt signaling pathway NAS 24431302
genes like me logo Genes that share ontologies with DKK2: view

No data available for SIGNOR curated interactions for DKK2 Gene

Drugs & Compounds for DKK2 Gene

(1) Drugs for DKK2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KY 02111 Pharma WNT signaling inhibitor 0

(1) ApexBio Compounds for DKK2 Gene

Compound Action Cas Number
KY 02111 WNT signaling inhibitor 1118807-13-8
genes like me logo Genes that share compounds with DKK2: view

Transcripts for DKK2 Gene

Unigene Clusters for DKK2 Gene

Dickkopf 2 homolog (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DKK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for DKK2 Gene

GeneLoc Exon Structure for
DKK2
ECgene alternative splicing isoforms for
DKK2

Expression for DKK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DKK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DKK2 Gene

This gene is overexpressed in Nerve - Tibial (x4.9) and Lung (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DKK2 Gene



NURSA nuclear receptor signaling pathways regulating expression of DKK2 Gene:

DKK2

SOURCE GeneReport for Unigene cluster for DKK2 Gene:

Hs.211869

mRNA Expression by UniProt/SwissProt for DKK2 Gene:

Q9UBU2-DKK2_HUMAN
Tissue specificity: Expressed in heart, brain, skeletal muscle and lung.

Evidence on tissue expression from TISSUES for DKK2 Gene

  • Lung(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DKK2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DKK2 Gene

Orthologs for DKK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DKK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKK2 34 35
  • 98.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DKK2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DKK2 34 35
  • 91.89 (n)
cow
(Bos Taurus)
Mammalia DKK2 34 35
  • 91.38 (n)
mouse
(Mus musculus)
Mammalia Dkk2 34 16 35
  • 89.58 (n)
rat
(Rattus norvegicus)
Mammalia Dkk2 34
  • 89.32 (n)
oppossum
(Monodelphis domestica)
Mammalia DKK2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DKK2 34 35
  • 76.21 (n)
lizard
(Anolis carolinensis)
Reptilia DKK2 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dkk2 34
  • 71.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia dkk2-A 34
zebrafish
(Danio rerio)
Actinopterygii dkk2 34 35
  • 67.91 (n)
Species where no ortholog for DKK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DKK2 Gene

ENSEMBL:
Gene Tree for DKK2 (if available)
TreeFam:
Gene Tree for DKK2 (if available)

Paralogs for DKK2 Gene

Paralogs for DKK2 Gene

(2) SIMAP similar genes for DKK2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DKK2: view

Variants for DKK2 Gene

Sequence variations from dbSNP and Humsavar for DKK2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000041025 -- 106,988,087(+) TCTCA(A/G)TCTCC intron-variant
rs1000065913 -- 106,981,056(+) GCTGA(C/T)AATTT intron-variant
rs1000075555 -- 106,978,010(+) AGGTC(C/T)GCTGG intron-variant
rs1000108013 -- 107,020,109(+) CAGGC(C/T)ATCAA intron-variant
rs1000120413 -- 106,941,303(+) AGAAG(G/T)ACTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DKK2 Gene

Variant ID Type Subtype PubMed ID
esv2728109 CNV deletion 23290073
esv2752020 CNV gain 17911159
esv3601699 CNV loss 21293372
nsv1149213 CNV duplication 26484159
nsv1149823 CNV duplication 26484159
nsv4453 CNV insertion 18451855

Variation tolerance for DKK2 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.79; 86.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DKK2 Gene

Human Gene Mutation Database (HGMD)
DKK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DKK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKK2 Gene

Disorders for DKK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DKK2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
apocrine sweat gland neoplasm
  • apocrine tumor
- elite association - COSMIC cancer census association via MalaCards
Search DKK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DKK2

Genetic Association Database (GAD)
DKK2
Human Genome Epidemiology (HuGE) Navigator
DKK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DKK2
genes like me logo Genes that share disorders with DKK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DKK2 Gene

Publications for DKK2 Gene

  1. Functional and structural diversity of the human Dickkopf gene family. (PMID: 10570958) Krupnik V.E. … McCarthy S.A. (Gene 1999) 2 3 4 64
  2. The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces. (PMID: 20004015) Olivares-Navarrete R. … Schwartz Z. (Biomaterials 2010) 3 22 64
  3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for DKK2 Gene

  • Cloud-Clone Corp. Antibodies for DKK2
  • Cloud-Clone Corp. Proteins for DKK2
  • Cloud-Clone Corp Assay Kits for DKK2

Sources for DKK2 Gene

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