Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DKK2 Gene

protein-coding   GIFtS: 62
GCID: GC04M107842

dickkopf 2 homolog (Xenopus laevis)

(Previous name: dickkopf (Xenopus laevis) homolog 2 )
 Explore 9 diseases affiliated with
DKK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DKK2    

Aliases
for DKK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dickkopf 2 Homolog (Xenopus Laevis)1 2     Dickkopf Related Protein-22
HDkk-21     Dickkopf-23
Dickkopf (Xenopus Laevis) Homolog 21     Dickkopf-Related Protein 22
DKK-22     Dickkopf-23
Dickkopf Homolog 22     Dkk-23

External Ids:    HGNC: 28921   Entrez Gene: 271232   Ensembl: ENSG000001550117   OMIM: 6054155   UniProtKB: Q9UBU23   

Export aliases for DKK2 gene to outside databases

Previous GC identifers: GC04M108253 GC04M108301 GC04M108200 GC04M108062 GC04M103577


Summaries
for DKK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DKK2:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich
regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act
as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence
of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor
related protein 6 (LRP6). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in
vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,
limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone
disease, cancer and Alzheimer disease (By similarity)

Gene Wiki entry for DKK2


Genomic Views
for DKK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DKK2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   RORalpha2   GATA-2   C/EBPalpha   FOXC1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DKK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DKK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

DKK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M107842:  view genomic region     (about GC identifiers)

Start:
 107,842,959 bp from pter      End:
 108,204,963 bp from pter
Size:
 362,005 bases      Orientation:
 minus strand

Proteins
for DKK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2 (See protein sequence)
Recommended Name: Dickkopf-related protein 2 precursor  
Size: 259 amino acids; 28447 Da
Subunit: Interacts with LRP5 and LRP6 (By similarity)
Subcellular location: Secreted
Secondary accessions: A0AVE9 B2R6S7 Q9UIU3

Explore the universe of human proteins at neXtProt for DKK2: NX_Q9UBU2

Post-translational modifications:

  • May be proteolytically processed by a furin-like protease1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBU2

    • DKK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055236.1  
    ENSEMBL proteins: 
     ENSP00000285311   ENSP00000421255   ENSP00000423797  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DKK2 (Dkk-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: DKK2
    OriGene Custom Protein Services for DKK2 
    GenScript Custom Purified and Recombinant Proteins Services for DKK2
    Novus Biologicals DKK2 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for DKK2
    Uscn Proteins for DKK2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA11742004


    DKK2 for ontologies           About GeneDecksing



    DKK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DKK2
    R&D Systems Antibodies for DKK2 (Dkk-2)
    Cell Signaling Technology (CST) Antibodies for DKK2 
    OriGene Antibodies: DKK2
    OriGene Custom Antibody Services for DKK2 
    GenScript Custom Superior Antibodies Services for DKK2
    Novus Biologicals DKK2 Antibodies
    Abcam antibodies for DKK2 
    Uscn Antibodies for DKK2
    ThermoFisher Antibody for DKK2

    Assay Products for DKK2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DKK2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DKK2

    Protein Domains /
    Families
    for DKK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DKK2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006796 Dickkopf_N

    Graphical View of Domain Structure for InterPro Entry Q9UBU2

    ProtoNet protein and cluster: Q9UBU2

    1 Blocks protein family: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    Function
    for DKK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in
    vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,
    limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone
    disease, cancer and Alzheimer disease (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DKK2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DKK2
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate DKK2 (see all 41):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-218 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmid: DKK2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DKK2 (see all 7)
    OriGene shRNA RFP: DKK2
    OriGene siRNA: DKK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DKK2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DKK2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DKK2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DKK2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DKK2 (NM_014421)
    Sino Biological Human cDNA Clone for DKK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DKK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DKK2
    LifeMap BioReagents: cell line associated with DKK2: PureStem Progenitor E68

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK2

    Animal Models:
         Mouse knock-outs for DKK2: Dkk2tm1Lex Dkk2tm1Lmgd Dkk2tm1Dwu
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dkk2):
     cellular  growth/size  hematopoietic system  immune system  skeleton 
     vision/eye 

    DKK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DKK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    2Reelin Pathway (Cajal-Retzius cells)
    		Reelin Pathway (Cajal-Retzius cells)1.00
    3Presenilin action in Notch and Wnt signaling
    		Presenilin action in Notch and Wnt signaling1.00
    4WNT Signaling
    		WNT Signaling1.00
    5Wnt Signaling Pathway
    		Wnt signaling pathway0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DKK2
        Reelin Pathway (Cajal-Retzius cells)
    WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for DKK2
        Wnt / Hedgehog / Notch

    1 BioSystems Pathway for DKK2 
        Presenilin action in Notch and Wnt signaling


    1         Kegg Pathway  (Kegg details for DKK2):
        Wnt signaling pathway


    DKK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DKK2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DKK2 (Q9UBU23 ENSP000002853114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP6O755813, ENSP000002613494I2D: score=1 STRING: ENSP00000261349
    DKK1ENSP000003630814STRING: ENSP00000363081
    KREMEN2ENSP000003044224STRING: ENSP00000304422
    LRP5ENSP000002943044STRING: ENSP00000294304
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway ----
    GO:0090090negative regulation of canonical Wnt receptor signaling pathway IDA11742004
    GO:0090263positive regulation of canonical Wnt receptor signaling pathway IDA12857724


    DKK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DKK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DKK2
    Search CenterWatch for drugs/clinical trials and news about DKK2 

    Transcripts
    for DKK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DKK2 gene: 
    NM_014421.2  

    Unigene Cluster for DKK2:

    Dickkopf 2 homolog (Xenopus laevis)
    Hs.211869  [show with all ESTs]
    Unigene Representative Sequence: AF177395
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285311(uc003hyi.3 uc003hyj.1) ENST00000513208(uc010ilw.1)
    ENST00000510534 ENST00000510463

    miRNA
    Products:             		 OriGene 3'-UTR Clone: DKK2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DKK2
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate DKK2 (see all 41):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-128 hsa-miR-766 hsa-miR-218 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmid: DKK2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DKK2 (see all 7)
    OriGene shRNA RFP: DKK2
    OriGene siRNA: DKK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DKK2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DKK2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DKK2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DKK2 (NM_014421)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DKK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DKK2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DKK2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DKK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DKK2

    Additional cDNA sequence: 

    AB033208.1 AF177395.1 AK309466.1 AK312695.1 AY358414.1 BC075077.2 BC075078.2 BC126328.1 
    BC126330.1 

    2 DOTS entries:

    DT.407612  DT.92418105 

    24/29 AceView cDNA sequences (see all 29):

    BX646253 AW316551 AI184289 AI863392 BQ959276 BC075078 AI093106 BC075077 
    AB033941 AF177395 AA720544 AY358414 NM_014421 AA481794 AI333962 BU902436 
    AB033208 BQ023032 AA300480 BQ011814 W55979 AW022313 AA648103 AI370632 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DKK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for DKK2

    Expression
    for DKK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DKK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGATTTGCTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DKK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    BoneMandibular ProcessBone
    BoneZeugopod Epiphyseal EndBone
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See DKK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DKK2

    SOURCE GeneReport for Unigene cluster: Hs.211869

    UniProtKB/Swiss-Prot: DKK2_HUMAN, Q9UBU2
    Tissue specificity: Expressed in heart, brain, skeletal muscle and lung

        SABiosciences Expression via Pathway-Focused PCR Array including DKK2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DKK2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DKK2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DKK2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DKK2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK2

    Orthologs
    for DKK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DKK2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DKK21 dickkopf homolog 2 (Xenopus laevis) 76.56(n)
    80.86(a)    		   422531  XM_420494.3  XP_420494.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DKK26
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343384.1(763367-766571)
    African clawed frog
    (Xenopus laevis)    		 Amphibia dkk2-A2 dickkopf homolog 2 77.03(n)    AJ300197.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dkk21 dickkopf homolog 2 (Xenopus laevis) 65.82(n)
    63.4(a)    		   792404  NM_001111209.1  NP_001104679.1 


    ENSEMBL Gene Tree for DKK2 (if available)
    TreeFam Gene Tree for DKK2 (if available) 

    Paralogs
    for DKK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DKK2 gene
    DKK42  DKK12  
    2 SIMAP similar genes for DKK2 using alignment to 4 protein entries:     DKK2_HUMAN (see all proteins):
    DKK1    DKK4

    DKK2 for paralogs           About GeneDecksing



    Genomic Variants
    for DKK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DKK2
         1 CNV: 8450
    Human Gene Mutation Database (HGMD): DKK2
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DKK2
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK2

    Disorders / Diseases
    for DKK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DKK2 for disorders           About GeneDecksing

    OMIM gene information: 605415    OMIM disorders: --

    9 diseases for DKK2:    About MalaCards
    spiradenoma    ewing's family of tumors    alcohol dependence    lung adenocarcinoma
    alcoholism    alzheimer's disease    adenocarcinoma    neuroblastoma
    melanoma

    Human Genome Epidemiology (HuGE) Navigator: DKK2 (6 documents)

    Export disorders for DKK2 gene to outside databases

    Publications
    for DKK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DKK2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with DKK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)1, 2, 3 Krupnik V.E.... McCarthy S.A. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. The roles of Wnt signaling modulators Dickkopf-1 (Dkk 1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstru ctured titanium surfaces. (PubMed id 20004015)1, 9 Olivares-Navarrete R....Schwartz Z. (2010)
    5. EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. (PubMed id 19247449)1, 9 Miyagawa Y....Kiyokawa N. (2009)
    6. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. (PubMed id 11742004)1, 9 Li L....Wu D. (2002)
    7. Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. (PubMed id 11137016)1, 9 Wu W....Niehrs C. (2000)
    8. The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. (PubMed id 21540552)1 Min J.K....Kwon Y.G. (2011)
    9. Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts. (PubMed id 21312269)1 Chan T.F....Lajeunesse D. (2011)
    10. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)

    External Searches for DKK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DKK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27123 HGNC: 2892 AceView: DKK2 Ensembl:ENSG00000155011 euGenes: HUgn27123
    ECgene: DKK2 Kegg: 27123 H-InvDB: DKK2

    Other Databases showing DKK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DKK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DKK2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DKK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DKK2 gene:
    Search GeneIP for patents involving DKK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DKK2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of DKK2
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for DKK2 (Dkk-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for DKK2 (Dkk-2)  
     OriGene Antibodies for DKK2   OriGene shRNA RFP for DKK2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DKK2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DKK2  
     OriGene Protein Over-expression Lysate for DKK2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DKK2   OriGene 3'-UTR Clone for DKK2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DKK2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DKK2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DKK2   OriGene Custom Protein Services for DKK2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DKK2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DKK2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKK2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DKK2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DKK2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DKK2
     GenScript Custom Purified and Recombinant Proteins Services for DKK2 GenScript cDNA clones with any tag delivered in your preferred vector for DKK2
     GenScript Custom Assay Services for DKK2 GenScript Custom Superior Antibodies Services for DKK2
     GenScript Custom overexpressing Cell Line Services for DKK2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for DKK2 

     Regulatory tfbs in DKK2 promoter
     Search Chromatin IP Primers for DKK2
     RT2 qPCR Primer Assay in human, mouse, rat DKK2
     GNC Network for DKK2
     SABiosciences PCR Arrays including human, mouse, rat DKK2
     Search Tocris compounds for DKK2
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for DKK2
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DKK2 antibodies
     DKK2 lysates
     Antibodies for DKK2
     See all of Abcam's Antibodies, Kits and Proteins for DKK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DKK2




     DKK2 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Line associated with DKK2: PureStem Progenitor E68
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK2
     SwitchGear 3'UTR luciferase reporter plasmids for DKK2
     SwitchGear Promoter luciferase reporter plasmids for DKK2
     ThermoFisher Antibody for DKK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DKK2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DKK2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4