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Aliases for DKK1 Gene

Aliases for DKK1 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 1 2 3 5
  • DKK-1 3 4
  • SK 3 4
  • Dickkopf (Xenopus Laevis) Homolog 1 2
  • Dickkopf 1 Homolog (Xenopus Laevis) 2
  • Dickkopf-Related Protein 1 3
  • Dickkopf-Like Protein 1 3
  • Dickkopf 1 Homolog 3
  • Dickkopf-1 Like 3
  • Dickkopf-1 4
  • HDkk-1 4

External Ids for DKK1 Gene

Previous GeneCards Identifiers for DKK1 Gene

  • GC10P052921
  • GC10P053966
  • GC10P053418
  • GC10P053744
  • GC10P054074
  • GC10P048051

Summaries for DKK1 Gene

Entrez Gene Summary for DKK1 Gene

  • This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]

CIViC summary for DKK1 Gene

GeneCards Summary for DKK1 Gene

DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Chiari Malformation Type I and Osteoporosis, Juvenile. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include signal transducer activity and low-density lipoprotein particle receptor binding. An important paralog of this gene is DKK2.

UniProtKB/Swiss-Prot for DKK1 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

Gene Wiki entry for DKK1 Gene

Additional gene information for DKK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK1 Gene

Genomics for DKK1 Gene

GeneHancer (GH) Regulatory Elements for DKK1 Gene

Promoters and enhancers for DKK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I052312 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.9 +2.8 2777 9.1 FOXA2 SIN3A FEZF1 ZNF2 ZNF143 FOS SP3 SP5 ZC3H11A REST DKK1 LOC105378305 MBL2 PRKG1-AS1 GC10P052330
GH10I052334 Enhancer 0.8 ENCODE dbSUPER 16.5 +21.0 21022 2.6 ELF3 SOX5 TEAD1 JUN HLF NFIL3 JUND FOSL2 HOMEZ DKK1 PRKG1-AS1 GC10P052330 GC10M052395
GH10I052485 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +173.3 173266 3.8 CTCF ZNF654 JUN USF2 CEBPB EP300 RAD21 RFX5 JUND GATA3 LINC01468 DKK1 GC10P052631
GH10I052482 Enhancer 0.4 UCNEbase 11.9 +167.9 167884 0.2 DKK1 PRKG1-AS1 LINC01468 GC10P052631
GH10I052439 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.2 +129.0 128979 7.3 FOXA2 NFIB SIN3A ZBTB40 RCOR1 ATF7 FOS USF2 CEBPB REST LINC01468 DKK1 THAP12P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DKK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DKK1 gene promoter:

Genomic Locations for DKK1 Gene

Genomic Locations for DKK1 Gene
chr10:52,314,281-52,318,042
(GRCh38/hg38)
Size:
3,762 bases
Orientation:
Plus strand
chr10:54,074,041-54,077,802
(GRCh37/hg19)

Genomic View for DKK1 Gene

Genes around DKK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DKK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DKK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK1 Gene

Proteins for DKK1 Gene

  • Protein details for DKK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94907-DKK1_HUMAN
    Recommended name:
    Dickkopf-related protein 1
    Protein Accession:
    O94907
    Secondary Accessions:
    • B2RC19

    Protein attributes for DKK1 Gene

    Size:
    266 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Interacts with LRP6 (PubMed:11448771, PubMed:17804805, PubMed:20093360, PubMed:22000856). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (PubMed:19746449). Forms a ternary complex with LRP6 and KREM1 (PubMed:27524201). Interacts with KREM1 (PubMed:17804805).

    Three dimensional structures from OCA and Proteopedia for DKK1 Gene

neXtProt entry for DKK1 Gene

Post-translational modifications for DKK1 Gene

  • Glycosylation at Ser61, Thr155, posLast=163163, posLast=181181, and Asn256

Other Protein References for DKK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DKK1 Gene

Domains & Families for DKK1 Gene

Gene Families for DKK1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DKK1 Gene

Suggested Antigen Peptide Sequences for DKK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94907

UniProtKB/Swiss-Prot:

DKK1_HUMAN :
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Belongs to the dickkopf family.
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Family:
  • Belongs to the dickkopf family.
genes like me logo Genes that share domains with DKK1: view

Function for DKK1 Gene

Molecular function for DKK1 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

Phenotypes From GWAS Catalog for DKK1 Gene

Gene Ontology (GO) - Molecular Function for DKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10383463
GO:0005515 protein binding IPI 11448771
GO:0008083 growth factor activity TAS 10383463
GO:0039706 co-receptor binding TAS 22988876
GO:0048019 receptor antagonist activity IDA 20723538
genes like me logo Genes that share ontologies with DKK1: view
genes like me logo Genes that share phenotypes with DKK1: view

Human Phenotype Ontology for DKK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DKK1 Gene

MGI Knock Outs for DKK1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DKK1 Gene

Localization for DKK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DKK1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 4
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 11448771
GO:0005886 plasma membrane IDA 16263759
GO:0031901 early endosome membrane TAS --
genes like me logo Genes that share ontologies with DKK1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DKK1 Gene

Pathways & Interactions for DKK1 Gene

genes like me logo Genes that share pathways with DKK1: view

SIGNOR curated interactions for DKK1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for DKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0000904 cell morphogenesis involved in differentiation IEA --
GO:0001706 endoderm formation IEA --
GO:0001707 mesoderm formation IEA --
GO:0001942 hair follicle development IEA --
genes like me logo Genes that share ontologies with DKK1: view

Drugs & Compounds for DKK1 Gene

(3) Drugs for DKK1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for DKK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DKK1: view

Transcripts for DKK1 Gene

Unigene Clusters for DKK1 Gene

Dickkopf 1 homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DKK1 Gene

No ASD Table

Relevant External Links for DKK1 Gene

GeneLoc Exon Structure for
DKK1
ECgene alternative splicing isoforms for
DKK1

Expression for DKK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DKK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of DKK1 Gene:

DKK1

SOURCE GeneReport for Unigene cluster for DKK1 Gene:

Hs.40499

mRNA Expression by UniProt/SwissProt for DKK1 Gene:

O94907-DKK1_HUMAN
Tissue specificity: Placenta.

Evidence on tissue expression from TISSUES for DKK1 Gene

  • Nervous system(4.4)
  • Bone(2.8)
  • Intestine(2.6)
  • Lung(2.6)
  • Skin(2.1)
  • Bone marrow(2)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DKK1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • skeleton
Organs:
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with DKK1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DKK1 Gene

Orthologs for DKK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DKK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DKK1 33 34
  • 98.62 (n)
cow
(Bos Taurus)
Mammalia DKK1 33 34
  • 89.14 (n)
dog
(Canis familiaris)
Mammalia DKK1 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912050 33
  • 83.58 (n)
mouse
(Mus musculus)
Mammalia Dkk1 33 16 34
  • 83.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DKK1 34
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DKK1 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves DKK-1 34
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DKK1 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dkk1 33
  • 61.96 (n)
Str.15023 33
African clawed frog
(Xenopus laevis)
Amphibia dkk1-A 33
zebrafish
(Danio rerio)
Actinopterygii dkk1b 33 34
  • 56.37 (n)
dkk1a 34
  • 43 (a)
OneToMany
dkk1 33
Species where no ortholog for DKK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DKK1 Gene

ENSEMBL:
Gene Tree for DKK1 (if available)
TreeFam:
Gene Tree for DKK1 (if available)

Paralogs for DKK1 Gene

Paralogs for DKK1 Gene

(2) SIMAP similar genes for DKK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DKK1: view

Variants for DKK1 Gene

Sequence variations from dbSNP and Humsavar for DKK1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1001501247 -- 52,313,995(+) C/T upstream_transcript_variant
rs1001773362 -- 52,313,148(+) C/A upstream_transcript_variant
rs1001960589 -- 52,313,440(+) A/T upstream_transcript_variant
rs1003174787 -- 52,315,316(+) TT/T intron_variant
rs1003721441 -- 52,315,578(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DKK1 Gene

Variant ID Type Subtype PubMed ID
nsv1045692 CNV gain 25217958

Variation tolerance for DKK1 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DKK1 Gene

Human Gene Mutation Database (HGMD)
DKK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DKK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKK1 Gene

Disorders for DKK1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for DKK1 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chiari malformation type i
  • cm1
osteoporosis, juvenile
  • idiopathic juvenile osteoporosis; ijo
chiari malformation
  • arnold chiari malformation
glucocorticoid-induced osteoporosis
  • steroid-induced osteoporosis
kummell's disease
  • kummell disease
- elite association - COSMIC cancer census association via MalaCards
Search DKK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DKK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DKK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DKK1 Gene

Publications for DKK1 Gene

  1. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PMID: 20093360) Bourhis E … Hannoush RN (The Journal of biological chemistry 2010) 3 4 22 58
  2. A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V). (PMID: 19746449) Murrills RJ … Bodine PV (Journal of cellular biochemistry 2009) 3 4 22 58
  3. Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population. (PMID: 19898734) Mencej-Bedrac S … Marc J (Calcified tissue international 2009) 3 22 44 58
  4. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. (PMID: 11448771) Semënov MV … He X (Current biology : CB 2001) 3 4 22 58
  5. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. (PMID: 10383463) Fedi P … Aaronson SA (The Journal of biological chemistry 1999) 3 4 22 58

Products for DKK1 Gene

  • Addgene plasmids for DKK1

Sources for DKK1 Gene

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