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DKK1 Gene

protein-coding GIFtS: 60

GC10P054074

dickkopf homolog 1 (Xenopus laevis)
(Previous name: dickkopf (Xenopus laevis) homolog 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
dickkopf homolog 1 (Xenopus laevis)¹ ²		dickkopf related protein-1²
SK¹ ² ³		dickkopf-1 like²
DKK-1¹ ²		dickkopf-related protein 1²
hDkk-1² ³		Dkk-1³
dickkopf (Xenopus laevis) homolog 1¹		Dickkopf-1³

External Ids:	HGNC: 2891¹	Entrez Gene: 22943²	Ensembl: ENSG00000107984⁷	UniProtKB: O94907³

Search outside databases for aliases for DKK1 gene

Previous GC identifers: GC10P052921 GC10P053966 GC10P053418 GC10P053744

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DKK1:

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich

regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels

of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in

patients with multiple myeloma. (provided by RefSeq)

UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907

Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary

complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in

vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,

limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone

disease, cancer and Alzheimer's disease

Gene Wiki entry for DKK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DKK1 gene upstream (promoter) region

:
AP-1 HNF-4alpha2 COUP-TF1 c-Jun c-Fos Sox9 p53 GATA-1 POU2F1 Meis-1

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for DKK1:

MePH28378-1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2 Ensembl cytogenetic band: 10q21.1 HGNC cytogenetic band: 10q11.2

DKK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P054074: view genomic region (about GC identifiers)

Start:	54,074,041 bp from pter
End:	54,077,802 bp from pter
Size:	3,762 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.10 NT_030059.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907 (See protein sequence)

Recommended Name: Dickkopf-related protein 1 precursor

Size: 266 amino acids; 28672 Da

Subunit: Interacts with LRP5 and LRP6 (By similarity)

Subcellular location: Secreted

Secondary accessions: B2RC19

REFSEQ proteins: NP_036374.1

ENSEMBL proteins:

ENSP00000363081

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for DKK1
	R&D Systems Recombinant & Natural Proteins for DKK1 (Dkk-1)
	Enzo Life Sciences proteins for DKK1
	HuPro® and/or Recombinant Proteins from Abnova for DKK1
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Proteins for DKK1
	Novus Biologicals Lysate for DKK1
	Sino Biological Recombinant Protein for DKK1

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IDA	16263759

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DKK1 for ontologies About GeneDecksing

Antibodies for DKK1:

	Millipore Mono- and Polyclonal Antibodies for the study of DKK1
	Sigma-Aldrich Antibodies for DKK1
	R&D Systems Antibodies for DKK1 (Dkk-1)
	Cell Signaling Technology (CST) Antibodies for DKK1
	Monoclonal and Polyclonal Antibodies from Abnova (DKK1)
	Origene Antibodies: DKK1
	Novus Biologicals Antibodies for DKK1
	Browse antibodies at Epitomics

Assays for DKK1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	R&D Systems ELISAs for DKK1 (Dkk-1)
	Enzo Life Sciences assays for DKK1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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DKK1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006796 Dickkopf_N

Graphical View of Domain Structure for InterPro Entry O94907

ProtoNet protein and cluster: O94907

1 Blocks protein family: IPB006796 Dickkopf

UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907

Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)

Similarity: Belongs to the dickkopf family

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DKK1)
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): DKK1 Origene shRNA RFP (see all 2): DKK1 Origene basic RS shRNA (see all 2): DKK1
		Applied Biosystems Silencer® siRNAs for DKK1
		Sigma-Aldrich siRNA Panels and siRNA for DKK1 Sigma-Aldrich shRNA for DKK1 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: DKK1 Origene Myc/DDK tagged cDNA clones in CMV expression vector: DKK1 Origene untagged cDNA clones in CMV expression vector: DKK1
		Sino Biological Human cDNA Clone for DKK1

UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907

Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary

complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in

vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning,

limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone

disease, cancer and Alzheimer's disease

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	10383463
GO:0005515	protein binding	IPI	17353931 19060904
GO:0008083	growth factor activity	TAS	10383463
GO:0050750	low-density lipoprotein receptor binding	IDA	16263759

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DKK1 for ontologies About GeneDecksing

Animal Models: 9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dkk1):

craniofacial	embryogenesis	lethality-prenatal/perinatal	limbs/digits/tail	nervous system
respiratory system	skeleton	taste/olfaction	vision/eye

DKK1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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DKK1 for pathways About GeneDecksing

2 Millipore Pathways for DKK1

	Selected targets of Oct-3/4
	Selected targets of p53

4 Sigma-Aldrich "Your Favorite Gene" Pathways for DKK1 (Your Favorite Gene powered by Ingenuity)

	Factors Promoting Cardiogenesis in Vertebrates
	Wnt/?-catenin Signaling
	Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
	Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

3 GeneAssist Pathways for DKK1

	WNT Signaling
	Reelin Pathway (Cajal-Retzius cells)
	Factors Promoting Cardiogenesis in Vertebrates

1 Kegg Pathway (Kegg details for DKK1):

hsa04310 Wnt signaling pathway

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DKK1

5/14 Interacting proteins for DKK1 (ENSP00000363081³ O94907^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MDFI	Q99750¹^,²	EBI-742864,EBI-724076 MINT-66302 EBI-742864,EBI-724076 MINT-66302
CORO1A	P31146¹	EBI-742864,EBI-1046676
SMAD9	O15198²	MINT-62104
CTNNB1	ENSP00000344456³	STRING: ENSP00000344456
DKK2	ENSP00000285311³	STRING: ENSP00000285311

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5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000904	cell morphogenesis involved in differentiation	--	--
GO:0003259	cardioblast anterior-lateral migration	--	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007492	endoderm development	--	--
GO:0030178	negative regulation of Wnt receptor signaling pathway	IEA	--

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DKK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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DKK1 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for DKK1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DKK1
10/42 Novoseek chemical compound relationships for DKK1 gene (see all 42 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thalidomide	5.18	7	17283219 (4), 19067746 (2), 17255354 (1)
bortezomib	4.58	5	17107351 (3), 19067746 (2)
lenalidomide	4.06	3	19067746 (2), 17255354 (1)
nemonapride	1.97	1	14985049 (1)
sphingosine	1.90	3	18420384 (1), 18341573 (1), 14522923 (1)
ru486	1.77	3	16449346 (3)
5-aza-2'deoxycytidine	1.67	2	19847810 (1), 16491118 (1)
bcl2	1.65	2	19895917 (1), 19217321 (1)
progesterone	1.64	14	16449346 (7), 19737954 (5), 17245340 (1), 12021176 (1)
zoledronic acid	1.57	2	19670154 (2)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DKK1)
		Applied Biosystems Silencer® siRNAs: NM_012242
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): DKK1 Origene shRNA RFP (see all 2): DKK1 Origene basic RS shRNA (see all 2): DKK1
		Sigma-Aldrich siRNA Panels and siRNA for DKK1 Sigma-Aldrich shRNA for DKK1 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		10 SABiosciences microRNAs that regulate DKK1:
		hsa-miR-217 hsa-miR-520e hsa-miR-302a hsa-miR-496 hsa-miR-373 hsa-miR-372 hsa-miR-93 hsa-miR-302c hsa-miR-520d-3p hsa-miR-302b

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_012242

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: DKK1
Origene Myc/DDK tagged cDNA clones in CMV expression vector: DKK1
Origene untagged cDNA clones in CMV expression vector: DKK1

Primers:		Origene genome-wide validated SYBR primer pairs: DKK1
		SABiosciences RT2 qPCR Primer Assay for DKK1: PPH01752A

REFSEQ mRNAs for DKK1 gene:

NM_012242.2

Additional cDNA sequence:

AF127563.1 AF177394.1 AK314902.1 AY359005.1 BC001539.2 CR591322.1 CR591735.1 CR594190.1

CR594616.1 CR595444.1 CR600818.1 CR601383.1 CR603030.1 CR603553.1 CR604811.1 CR605923.1

CR610857.1 CR625465.1

6 DOTS entries:

DT.215189 DT.97845178 DT.95249156 DT.100705681 DT.121258630 DT.91766563

24/215 AceView cDNA sequences (see all 215 ):

BE138776 AA253446 CR601383 CR594616 CR605923 BM832800 CR625465 BM781822

CA489233 AI440184 CR603030 AI095783 AI952513 BM745250 BX102027 CB216128

AI954044 BC001539 BM759916 BG178745 BU752259 BM545035 BU170594 BE908837

highest scoring ESTs for DKK1:

AA031969 AA032060 AA035345 AA035443 AA035583 AA042806 AA088618 AA115249 AA115337 AA137219

Unigene Cluster for DKK1:

Dickkopf homolog 1 (Xenopus laevis)

Hs.40499 [show with all ESTs]

Unigene Representative Sequence: CR594190

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000467359 ENST00000373970 ENST00000494277 ENST00000476752

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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DKK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DKK1

¹ / ² / ³

3 probe-sets matching DKK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35977_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB020315	0.20	1.00	0.72	1
204602_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012242	0.60	1.00	0.82	1
204602_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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DKK1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: AAAATACTAG

SOURCE GeneReport for Unigene cluster: Hs.40499

Expression variation in blood from EXPOLDB for DKK1

UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907

Tissue specificity: Placenta

Primers:		Origene genome-wide validated SYBR primer pairs: DKK1
		SABiosciences RT2 qPCR Primer Assay for DKK1: PPH01752A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for DKK1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	DKK1¹	--	dickkopf homolog 1 (Xenopus laevis)	98.62(n) 99.25(a)	450465 XM_001163253.1 XP_001163253.1
cow (Bos taurus)	DKK1¹	--	dickkopf homolog 1 (Xenopus laevis)	89.14(n) 90.53(a)	504445 XM_580572.3 XP_580572.2
rat (Rattus norvegicus)	Dkk1¹	--	dickkopf homolog 1 (Xenopus laevis)	83.58(n) 82.71(a)	293897 XM_219804.4 XP_219804.3
mouse (Mus musculus)	Dkk1^{1, 5}	19⁵	dickkopf homolog 1 (Xenopus laevis)^{1, 5}	83.33(n)¹ 83.08(a)¹	13380¹ NM_010051.3¹ NP_034181.2¹ AF030433⁵ AK141693⁵ (see all 7)
chicken (Gallus gallus)	DKK1¹	--	dickkopf homolog 1 (Xenopus laevis)	59.24(n) 58.85(a)	374156 XM_421563.2 XP_421563.2

About this table Species with no ortholog for DKK1

ENSEMBL Gene Tree for DKK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DKK1 gene

DKK4² DKK2²

DKK1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/22 NCBI SNPs in DKK1 are shown (see all 22 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--				--
	rs11001553^1,2	C,F,A	48050743(+)	`ATATCC/TACACA`	1	--	ng5¹		2		NA EA	160
--	rs11001548^1,2	C,F	48050402(+)	`TGACAC/TTTATA`	1	--	ng5¹		2		NA EA	160
--	rs72789115^1,2	C	48050170(+)	`CCTTCT/GCCCAG`	1	--	ng5¹		1		NA	72
--	rs75672193^1,2	F	54077116(+)	`TTTTTG/TAAATA`	1	--	ut3¹		2		EA WA	138
--	rs11001556^1,2	C	48051136(+)	`CATTTC/TCCTCT`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs75869144^1,2	F	48050188(+)	`TAGGAT/CTTTTT`	1	--	ng5¹		1		WA	50
--	rs75932495^1,2	F	48049920(+)	`CAGGCG/AGATTT`	1	--	ng5¹		1		NA	72
--	rs75166013^1,2	F	48049919(+)	`GCAGGC/GGGATT`	1	--	ng5¹		1		NA	72
--	rs1969548^1,2	--	48055409(+)	`TTTGCA/GGTATC`	1	--	ng3¹		0	--	--	--	--
--	rs79572857^1,2	--	48050370(-)	`GAGTTG/TGGAAA`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for DKK1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DKK1: --

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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DKK1 for disorders About GeneDecksing

OMIM: 605189

10/121 Novoseek disease relationships for DKK1 gene (see all 121 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
multiple myeloma	17.92	31	17255354 (6), 16646053 (6), 19067746 (5), 14695408 (4) (see all 11)
bone metastases	12.72	15	17876334 (7), 18561248 (3), 18546262 (3), 18453541 (1) (see all 5)
placental choriocarcinoma	9.61	4	17026960 (4)
tumorigenicity	8.98	9	18157634 (3), 17141200 (3), 14555616 (2), 19247449 (1)
mgus	6.41	3	16646053 (2), 19067746 (1)
osteosarcoma	5.62	10	17987039 (7), 15965110 (2), 12740383 (1)
pachydermoperiostosis	5.42	3	20042673 (3)
escc	4.93	6	19408050 (6)
medulloblastoma	4.80	6	17329407 (5), 12649343 (1)
ankylosing spondylitis	4.71	8	20039407 (8)

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Human Genome Epidemiology Navigator: DKK1 (8 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/177 PubMed articles for DKK1 gene (see all 177 ):

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. (PubMed id 10383463)^{1, 3, 4} Fedi P.... Aaronson S.A. (1999)
The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. (PubMed id 10965128)^{1, 3, 4} Roessler E.... Muenke M. (2000)
Functional and structural diversity of the human Dickkopf gene family. (PubMed id 10570958)^{1, 3, 4} Krupnik V.E.... McCarthy S.A. (1999)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. (PubMed id 17987039)^{1, 3} Lee N....Gregory C.A. (2007)
Dickkopf-1 mediated tumor suppression in human breast carcinoma cells. (PubMed id 18157634)^{1, 3} Mikheev A.M....Zarbl H. (2008)
Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis. (PubMed id 18561248)^{1, 3} Hall C.L....Keller E.T. (2008)
Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. (PubMed id 19303159)^{1, 3} Yu B....Qin W. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22943	HGNC: 2891	AceView: DKK1	Ensembl:ENSG00000107984	euGenes: HUgn22943
ECgene: DKK1	Kegg: 22943	H-InvDB: DKK1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for DKK1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DKK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for DKK1 gene:

Search GeneIP for patents involving DKK1

GeneCards and IP:

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GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

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Category			ACSF3 acyl-CoA synthetase family member 3
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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DKK1 Gene

protein-coding GIFtS: 60

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