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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DKK1 Gene

protein-coding   GIFtS: 64
GCID: GC10P054074

Dickkopf WNT Signaling Pathway Inhibitor 1

(Previous names: dickkopf (Xenopus laevis) homolog 1, dickkopf 1 homolog...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dickkopf WNT Signaling Pathway Inhibitor 11 2     Dickkopf Related Protein-12
SK2 3     Dickkopf-1 Like2
hDkk-12 3     Dickkopf-Like Protein 12
Dickkopf (Xenopus Laevis) Homolog 11     Dickkopf-Related Protein 12
Dickkopf 1 Homolog (Xenopus Laevis)1     Dickkopf-13
DKK-12     Dkk-13
Dickkopf 1 Homolog2     

External Ids:    HGNC: 28911   Entrez Gene: 229432   Ensembl: ENSG000001079847   OMIM: 6051895   UniProtKB: O949073   

Export aliases for DKK1 gene to outside databases

Previous GC identifers: GC10P052921 GC10P053966 GC10P053418 GC10P053744 GC10P048051


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DKK1 Gene:
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine
rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway.
Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic
bone lesions in patients with multiple myeloma. (provided by RefSeq, Jul 2008)

GeneCards Summary for DKK1 Gene: 
DKK1 (dickkopf WNT signaling pathway inhibitor 1) is a protein-coding gene. Diseases associated with DKK1 include myeloma, and multiple myeloma, and among its related super-pathways are Wnt Signaling Pathway and Non-Canonical Wnt Pathway. GO annotations related to this gene include low-density lipoprotein particle receptor binding and signal transducer activity. An important paralog of this gene is DKK4.

UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
formation and bone disease, cancer and Alzheimer disease

Gene Wiki entry for DKK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DKK1 gene promoter:
         GATA-6   AP-1   NCX/Ncx   ATF-2   Nkx2-5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDKK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DKK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DKK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q21.1   HGNC cytogenetic band: 10q11.2

DKK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKK1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P054074:  view genomic region     (about GC identifiers)

Start:
54,074,041 bp from pter      End:
54,077,802 bp from pter
Size:
3,762 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907 (See protein sequence)
Recommended Name: Dickkopf-related protein 1 precursor  
Size: 266 amino acids; 28672 Da
Subunit: Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions
3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for DKK1:
3S2K (3D)        3S8V (3D)    
Secondary accessions: B2RC19

Explore the universe of human proteins at neXtProt for DKK1: NX_O94907

Explore proteomics data for DKK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94907

  • DKK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DKK1 Protein Expression
    REFSEQ proteins: NP_036374.1  
    ENSEMBL proteins: 
     ENSP00000363081  

    Human Recombinant Protein Products for DKK1: 
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    Novus Biologicals DKK1 Proteins
    Novus Biologicals DKK1 Lysates
    Sino Biological Recombinant Protein for DKK1
    Sino Biological Cell Lysate for DKK1 
    ProSpec Recombinant Protein for DKK1
    Cloud-Clone Corp. Proteins for DKK1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA11448771
    GO:0005886plasma membrane IDA16263759

    DKK1 for ontologies           About GeneDecksing



    DKK1 Antibody Products: 
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    Assay Products for DKK1: 
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    Enzo Life Sciences assays for DKK1
    Cloud-Clone Corp. ELISAs for DKK1 
    Cloud-Clone Corp. CLIAs for DKK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006796 Dickkopf_N

    Graphical View of Domain Structure for InterPro Entry O94907

    ProtoNet protein and cluster: O94907

    1 Blocks protein domain: IPB006796 Dickkopf

    UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907
    Domain: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)
    Similarity: Belongs to the dickkopf family


    DKK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DKK1_HUMAN, O94907
    Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary
    complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important
    role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial
    patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone
    formation and bone disease, cancer and Alzheimer disease

         Summary:

    During embryonic development, DKK1 as signaling molecule is secreted from the following cells: Prechordal Plate Cells in Prechordal Plate It affects the following cells: Cardiomyocyte Progenitor Cells in Myocardium, Intraembryonic Neural Ectoderm Cells in Neural Plate (see all 3).

    DKK1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Cardiac mesoderm embryoid bodies from Heart, Floating clusters from (see all).

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS10383463
    GO:0005515protein binding IPI11448771
    GO:0008083growth factor activity TAS10383463
    GO:0048019receptor antagonist activity IDA--
    GO:0050750low-density lipoprotein particle receptor binding IDA16263759
         
    DKK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DKK1:
     Increased G1 DNA content 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dkk1):
     cellular  craniofacial  embryogenesis  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system  renal/urinary system  respiratory system  skeleton 
     taste/olfaction  vision/eye 

    DKK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dkk1tm1Lmgd for DKK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DKK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DKK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DKK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DKK1 

    miRNA
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    miRTarBase miRNAs that target DKK1:
    hsa-mir-31 (MIRT005874), hsa-mir-29a (MIRT003609)

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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate DKK1 (see all 36):
    hsa-miR-520e hsa-miR-302d hsa-miR-519a hsa-miR-372 hsa-miR-508-5p hsa-miR-186 hsa-miR-302b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidDKK1 3' UTR sequence
    Inhib. RNA
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of DKK1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DKK1 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53
    3Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    4Wnt signaling network
    Wnt signaling network
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DKK1
        Selected targets of Oct-3/4
    Selected targets of p53

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DKK1
        Factors Promoting Cardiogenesis in Vertebrates
    Reelin Pathway (Cajal-Retzius cells)
    WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for DKK1
        Wnt / Hedgehog / Notch

    5/7 BioSystems Pathways for DKK1 (see all 7)
        Cardiac Progenitor Differentiation
    Wnt Signaling Pathway NetPath
    Presenilin action in Notch and Wnt signaling
    Direct p53 effectors
    Wnt signaling network

    2 Sino Biological Pathways for DKK1 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway


    1         Kegg Pathway  (Kegg details for DKK1):
        Wnt signaling pathway


    DKK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DKK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for DKK1 (O949071, 2, 3 ENSP000003630814) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 2, 3, ENSP000002303214EBI-742864,EBI-724076 MINT-66302 I2D: score=5 STRING: ENSP00000230321
    SMAD9O151982, 3, ENSP000003691544MINT-62104 I2D: score=3 STRING: ENSP00000369154
    CORO1AP311463, ENSP000002191504I2D: score=2 STRING: ENSP00000219150
    KREMEN1Q96MU83, ENSP000003312424I2D: score=1 STRING: ENSP00000331242
    LRP6O755813, ENSP000002613494I2D: score=2 STRING: ENSP00000261349
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000904cell morphogenesis involved in differentiation IEA--
    GO:0001706endoderm formation IEA--
    GO:0001707mesoderm formation IEA--
    GO:0001942hair follicle development IEA--

    DKK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DKK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DKK1

    4 Novoseek inferred chemical compound relationships for DKK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thalidomide 39.6 4 19067746 (2), 17255354 (1), 17283219 (1)
    glycogen 37.5 4 17079847 (1), 15229249 (1), 15965110 (1), 17437412 (1)
    lithium 16.5 3 15592505 (1), 17437412 (1)
    progesterone 3.57 24 16449346 (6), 19737954 (5), 12021176 (1), 17245340 (1)

    Search CenterWatch for drugs/clinical trials and news about DKK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DKK1 gene: 
    NM_012242.2  

    Unigene Cluster for DKK1:

    Dickkopf 1 homolog (Xenopus laevis)
    Hs.40499  [show with all ESTs]
    Unigene Representative Sequence: NM_012242
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373970(uc001jjr.3) ENST00000467359 ENST00000494277 ENST00000476752


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    hsa-miR-520e hsa-miR-302d hsa-miR-519a hsa-miR-372 hsa-miR-508-5p hsa-miR-186 hsa-miR-302b hsa-miR-509-3-5p
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    Additional mRNA sequence: 

    AF127563.1 AF177394.1 AK314902.1 AY359005.1 BC001539.2 

    6 DOTS entries:

    DT.215189  DT.97845178  DT.121258630  DT.95249156  DT.100705681  DT.91766563 

    24/215 AceView cDNA sequences (see all 215):

    AI440184 CA488204 CR591322 CR605923 BE221148 AA253464 BU170594 CA487295 
    AA032060 BM832800 CR610857 CR603553 BM561751 BX102027 CR603030 AI954044 
    AI952513 AA253446 CR601383 AI273972 AA693679 BC001539 BE908837 AI095783 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DKK1 expression in normal human tissues (normalized intensities)      DKK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATACTAG
    DKK1 Expression
    About this image


    DKK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Kidney (Urinary System)    fully expand to see all 17 entries
             Distal Renal Vesicle Cells Renal Vesicle
             Proximal Tubule
             visceral organ/mesonephros of male/mesonephric tubule of male   
     
     Bone (Muscoskeletal System)    fully expand to see all 11 entries
             Progress Zone Cells Limb Bud
             Thoracic Rib
             Human fetal bone marrow-derived mesenchymal stromal cells
             HyStem+BMP4-induced MEL2 cells
             skeleton/cranium/viscerocranium   
     
     Dermis (Integumentary System)    fully expand to see all 8 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
             Human Hair Outer Root Sheath Cells (HHORSC)   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Progress Zone Cells Limb Bud
             Autopod
             limb/hindlimb/hind-paw   
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             Human umbilical vein endothelial cells (HUVEC)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
             mouse/organ system/cardiovascular system/arterial system   

    See DKK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DKK1

    SOURCE GeneReport for Unigene cluster: Hs.40499

    UniProtKB/Swiss-Prot: DKK1_HUMAN, O94907
    Tissue specificity: Placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including DKK1 (see all 6): 
              Notch Signaling Targets in human mouse rat
              Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DKK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DKK1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dkk11 , 5 dickkopf homolog 1 (Xenopus laevis)1, 5 83.33(n)1
    83.08(a)1
      19 (25.16 cM)5
    133801  NM_010051.31  NP_034181.21 
     305458635 
    chicken
    (Gallus gallus)
    Aves DKK-16
    Dkk-1; Uncharacterized protein
    51(a)
    1 ↔ 1
    6(9764380-9766014)
    lizard
    (Anolis carolinensis)
    Reptilia DKK16
    dickkopf 1 homolog (Xenopus laevis)
    58(a)
    1 ↔ 1
    GL343268.1(272971-279064)
    African clawed frog
    (Xenopus laevis)
    Amphibia dkk1-A2 dickkopf homolog 1 73.35(n)    AF030434.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dkk12 dickkopf 1 77.34(n)   30197  AF116852.1 


    ENSEMBL Gene Tree for DKK1 (if available)
    TreeFam Gene Tree for DKK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DKK1 gene
    DKK42  DKK22  
    2 SIMAP similar genes for DKK1 using alignment to 2 protein entries:     DKK1_HUMAN (see all proteins):
    DKK2    DKK4

    DKK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/48 SNPs in DKK1 are shown (see all 48)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018844961,2
    C--54076059(+) GGAATA/GTGTGT 2 I M mis11Minor allele frequency- G:0.00EU 1321
    rs1433889121,2
    C,F--54076118(+) TGAAAA/G/TCTTTG 3 N S I mis12NA EU 5870
    rs768103751,2
    C--54076213(+) AGACTA/CATTCT 1 -- int10--------
    rs1446648311,2
    --54076259(+) GAAACG/TATGCA 1 -- int10--------
    rs1479003551,2
    C--54076266(+) TGCAGC/GTTTAA 1 -- int10--------
    rs15691981,2
    C,F,O,A,H--54076271(+) GTTTAA/GCAGTA 1 -- int128Minor allele frequency- G:0.38MN NS EA NA WA CSA EU 4275
    rs1920246681,2
    C--54076274(+) TAACAC/GTAACT 1 -- int10--------
    rs1839518491,2
    C,F--54076310(+) CCTTCA/G/TTAGGA 1 -- int11EU 1323
    rs1161110981,2
    C--54076311(+) CTTCGT/CAGGAC 1 -- int12Minor allele frequency- C:0.00WA EU 1441
    rs2005889371,2
    --54076438(+) CATAGA/GAGAAA 2 R syn10--------

    HapMap Linkage Disequilibrium report for DKK1 (54074041 - 54077802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DKK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv895400CNV Gain21882294
    nsv895399CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DKK1
    DNA2.0 Custom Variant and Variant Library Synthesis for DKK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605189    OMIM disorders: --

    20/71 diseases for DKK1 (see all 71):    About MalaCards
    myeloma    multiple myeloma    placental choriocarcinoma    ewing's family of tumors
    hepatoblastoma    osteonecrosis    renal osteodystrophy    cutaneous malignant melanoma
    paget's disease of bone    ectopic pregnancy    familial adenomatous polyposis    bone density
    idiopathic pulmonary fibrosis    holoprosencephaly    temporal lobe epilepsy    choriocarcinoma
    medulloblastoma    neural tube defects    langerhans-cell histiocytosis    barrett's esophagus

    2 diseases from the University of Copenhagen DISEASES database for DKK1:
    Multiple myeloma     Osteoporosis

    DKK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/21 Novoseek inferred disease relationships for DKK1 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteolytic 69.1 19 18546262 (3), 19111823 (3), 17876334 (3), 16447163 (3) (see all 9)
    bone diseases 44.4 6 16646053 (2), 17255354 (1), 17107351 (1), 18294945 (1)
    myeloma 42.9 18 16646053 (5), 19067746 (4), 14695408 (2), 17107351 (1) (see all 6)
    osteoporosis 41.9 2 15110782 (2)
    familial adenomatous polyposis 36 2 16491118 (1), 15342948 (1)
    monoclonal gammopathy 33.7 4 17255354 (1), 16646053 (1), 18005268 (1)
    hepatoblastoma 30.8 1 15958610 (1)
    tumors 30.6 41 11840333 (3), 19247449 (2), 19746230 (2), 18157634 (2) (see all 21)
    prostate cancer 28 3 18453541 (1)
    osteosarcoma 24.9 8 17987039 (2), 15965110 (2), 12740383 (1)

    Genetic Association Database (GAD): DKK1
    Human Genome Epidemiology (HuGE) Navigator: DKK1 (13 documents)

    Export disorders for DKK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DKK1 gene, integrated from 9 sources (see all 291):
    (articles sorted by number of sources associating them with DKK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cell-based Dkk1 binding assay reveals roles for ext racellular domains of LRP5 in Dkk1 interaction and highlights differences betwe en wild-type and the high bone mass mutant LRP5(G171V). (PubMed id 19746449)1, 2, 9 Murrills R.J....Bodine P.V. (2009)
    2. Analysis of association of LRP5, LRP6, SOST, DKK1, an d CTNNB1 genes with bone mineral density in a Slovenian population. (PubMed id 19898734)1, 4, 9 Mencej-Bedrac S....Marc J. (2009)
    3. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. (PubMed id 11448771)1, 2, 9 Semenov M.V....He X. (2001)
    4. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling co mplex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PubMed id 20093360)1, 2, 9 Bourhis E....Hannoush R.N. (2010)
    5. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. (PubMed id 10383463)1, 2, 9 Fedi P.... Aaronson S.A. (1999)
    6. Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains. (PubMed id 21805521)1, 2 Haniu M....Lu H.S. (2011)
    7. Structural basis of Wnt signaling inhibition by Dickk opf binding to LRP5/6. (PubMed id 22000856)1, 2 Ahn V.E....Weis W.I. (2011)
    8. Analysis of copy number variation in 8,842 Korean ind ividuals reveals 39 genes associated with hepatic biomarkers AST and ALT. (PubMed id 20797317)1, 4 Kim H.Y....Kim H. (2010)
    9. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22943 HGNC: 2891 AceView: DKK1 Ensembl:ENSG00000107984 euGenes: HUgn22943
    ECgene: DKK1 Kegg: 22943 H-InvDB: DKK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DKK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DKK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DKK1 gene:
    Search GeneIP for patents involving DKK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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