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Aliases for DKK1 Gene

Aliases for DKK1 Gene

  • Dickkopf WNT Signaling Pathway Inhibitor 1 2 3
  • HDkk-1 3 4
  • DKK-1 3 4
  • SK 3 4
  • Dickkopf (Xenopus Laevis) Homolog 1 2
  • Dickkopf 1 Homolog (Xenopus Laevis) 2
  • Dickkopf Related Protein-1 3
  • Dickkopf-Like Protein 1 3
  • Dickkopf 1 Homolog 3
  • Dickkopf-1 Like 3
  • Dickkopf-1 4

External Ids for DKK1 Gene

Previous GeneCards Identifiers for DKK1 Gene

  • GC10P052921
  • GC10P053966
  • GC10P053418
  • GC10P053744
  • GC10P054074
  • GC10P048051

Summaries for DKK1 Gene

Entrez Gene Summary for DKK1 Gene

  • This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

GeneCards Summary for DKK1 Gene

DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include idiopathic juvenile osteoporosis and leprechaunism. Among its related pathways are Signaling by GPCR and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include signal transducer activity and low-density lipoprotein particle receptor binding. An important paralog of this gene is DKK4.

UniProtKB/Swiss-Prot for DKK1 Gene

  • Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gene Wiki entry for DKK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DKK1 Gene

Genomics for DKK1 Gene

Regulatory Elements for DKK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DKK1 Gene

Chromosome:
10
Start:
52,314,281 bp from pter
End:
52,318,042 bp from pter
Size:
3,762 bases
Orientation:
Plus strand

Genomic View for DKK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DKK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DKK1 Gene

Proteins for DKK1 Gene

  • Protein details for DKK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94907-DKK1_HUMAN
    Recommended name:
    Dickkopf-related protein 1
    Protein Accession:
    O94907
    Secondary Accessions:
    • B2RC19

    Protein attributes for DKK1 Gene

    Size:
    266 amino acids
    Molecular mass:
    28672 Da
    Quaternary structure:
    • Interacts with LRP6. Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling.

    Three dimensional structures from OCA and Proteopedia for DKK1 Gene

neXtProt entry for DKK1 Gene

Proteomics data for DKK1 Gene at MOPED

Post-translational modifications for DKK1 Gene

  • Glycosylation at Ser 61, Thr 155, Ser 163, Thr 181, and Asn 256
  • Modification sites at PhosphoSitePlus

Other Protein References for DKK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DKK1 (DKK1)

Protein Products

No data available for DME Specific Peptides for DKK1 Gene

Domains & Families for DKK1 Gene

Protein Domains for DKK1 Gene

Suggested Antigen Peptide Sequences for DKK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94907

UniProtKB/Swiss-Prot:

DKK1_HUMAN :
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Belongs to the dickkopf family.
Domain:
  • The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Family:
  • Belongs to the dickkopf family.
genes like me logo Genes that share domains with DKK1: view

No data available for Gene Families for DKK1 Gene

Function for DKK1 Gene

Molecular function for DKK1 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Gene Ontology (GO) - Molecular Function for DKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 10383463
GO:0005515 protein binding IPI 11448771
GO:0008083 growth factor activity TAS 10383463
GO:0039706 co-receptor binding IPI 11433302
GO:0048019 receptor antagonist activity IDA 20723538
genes like me logo Genes that share ontologies with DKK1: view
genes like me logo Genes that share phenotypes with DKK1: view

Animal Models for DKK1 Gene

MGI Knock Outs for DKK1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DKK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DKK1 Gene

Localization for DKK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DKK1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DKK1 Gene COMPARTMENTS Subcellular localization image for DKK1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 4
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 11448771
GO:0005886 plasma membrane IDA 16263759
GO:0031901 early endosome membrane TAS --
genes like me logo Genes that share ontologies with DKK1: view

Pathways & Interactions for DKK1 Gene

genes like me logo Genes that share pathways with DKK1: view

PCR Array Products

SIGNOR curated interactions for DKK1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for DKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0000904 cell morphogenesis involved in differentiation IEA --
GO:0001706 endoderm formation IEA --
GO:0001707 mesoderm formation IEA --
GO:0001942 hair follicle development IEA --
genes like me logo Genes that share ontologies with DKK1: view

Drugs & Compounds for DKK1 Gene

(3) Drugs for DKK1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma 206
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 776

(1) Additional Compounds for DKK1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
genes like me logo Genes that share compounds with DKK1: view

Transcripts for DKK1 Gene

mRNA/cDNA for DKK1 Gene

Unigene Clusters for DKK1 Gene

Dickkopf 1 homolog (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DKK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DKK1 Gene

No ASD Table

Relevant External Links for DKK1 Gene

GeneLoc Exon Structure for
DKK1
ECgene alternative splicing isoforms for
DKK1

Expression for DKK1 Gene

mRNA expression in normal human tissues for DKK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for DKK1 Gene Hs.40499

mRNA Expression by UniProt/SwissProt for DKK1 Gene

O94907-DKK1_HUMAN
Tissue specificity: Placenta
genes like me logo Genes that share expression patterns with DKK1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DKK1 Gene

Orthologs for DKK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DKK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DKK1 35
  • 89.14 (n)
  • 90.53 (a)
DKK1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dkk1 35
  • 83.33 (n)
  • 83.08 (a)
Dkk1 16
Dkk1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DKK1 35
  • 98.62 (n)
  • 99.25 (a)
DKK1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dkk1 35
  • 83.58 (n)
  • 82.71 (a)
dog
(Canis familiaris)
Mammalia DKK1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DKK1 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DKK1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves DKK-1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DKK1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dkk1 35
  • 61.96 (n)
  • 60.48 (a)
Str.15023 35
African clawed frog
(Xenopus laevis)
Amphibia dkk1-A 35
zebrafish
(Danio rerio)
Actinopterygii dkk1 35
dkk1b 35
  • 56.37 (n)
  • 55.3 (a)
dkk1a 36
  • 43 (a)
OneToMany
dkk1b 36
  • 47 (a)
OneToMany
Species with no ortholog for DKK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DKK1 Gene

ENSEMBL:
Gene Tree for DKK1 (if available)
TreeFam:
Gene Tree for DKK1 (if available)

Paralogs for DKK1 Gene

Paralogs for DKK1 Gene

(2) SIMAP similar genes for DKK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DKK1: view

Variants for DKK1 Gene

Sequence variations from dbSNP and Humsavar for DKK1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1569198 -- 52,316,511(+) GTTTA(A/G)CAGTA intron-variant
rs1969548 -- 52,317,807(+) TTTGC(A/G)GTATC downstream-variant-500B
rs1969549 -- 52,317,808(+) TTGCA(G/T)TATCT downstream-variant-500B
rs3031912 -- 52,317,805(+) AATTT(-/CA/GC)AGTAT downstream-variant-500B
rs3750741 -- 52,317,334(-) TAAAG(A/G)GAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DKK1 Gene

Variant ID Type Subtype PubMed ID
nsv895399 CNV Gain 21882294
nsv895400 CNV Gain 21882294

Variation tolerance for DKK1 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DKK1 Gene

HapMap Linkage Disequilibrium report
DKK1
Human Gene Mutation Database (HGMD)
DKK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DKK1 Gene

Disorders for DKK1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for DKK1 Gene - From: Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
idiopathic juvenile osteoporosis
  • juvenile osteoporosis
leprechaunism
  • donohue syndrome
glucocorticoid-induced osteoporosis
  • steroid-induced osteoporosis
myeloma
  • multiple myeloma
multiple myeloma
  • plasma cell myeloma
- elite association
Search DKK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DKK1

Genetic Association Database (GAD)
DKK1
Human Genome Epidemiology (HuGE) Navigator
DKK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DKK1
genes like me logo Genes that share disorders with DKK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DKK1 Gene

Publications for DKK1 Gene

  1. Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis. (PMID: 19895917) Ko J.Y. … Tseng S.L. (Bone 2010) 23 67
  2. LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse. (PMID: 20053636) Sakane H. … Kikuchi A. (J. Cell. Sci. 2010) 23 67
  3. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. (PMID: 20139903) Zhou X.L. … Ye L.H. (Acta Pharmacol. Sin. 2010) 23 67
  4. Mesenchymal stromal cells, colony-forming unit fibroblasts, from bone marrow of untreated advanced breast and lung cancer patients suppress fibroblast colony formation from healthy marrow. (PMID: 19388812) Hofer E.L. … Chasseing N.A. (Stem Cells Dev. 2010) 23 67
  5. MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3. (PMID: 19815336) Revet I. … Geerts D. (Cancer Lett. 2010) 23 67

Products for DKK1 Gene

Sources for DKK1 Gene

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