Aliases for DKK1 Gene
External Ids for DKK1 Gene
Previous GeneCards Identifiers for DKK1 Gene
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
GeneCards Summary for DKK1 Gene
DKK1 (Dickkopf WNT Signaling Pathway Inhibitor 1) is a Protein Coding gene. Diseases associated with DKK1 include Multiple Myeloma and Idiopathic Juvenile Osteoporosis. Among its related pathways are BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation and phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex. GO annotations related to this gene include signal transducer activity and low-density lipoprotein particle receptor binding. An important paralog of this gene is DKK2.
UniProtKB/Swiss-Prot for DKK1 Gene
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).