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DKFZP434L187 Gene

RNA gene   GIFtS: 19
GCID: GC15P030488

Uncharacterized LOC26082


  Search for DKFZP434L187
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 2

Aliases
Uncharacterized LOC260822

External Ids:    Entrez Gene: 260822   Ensembl: ENSG000002259307   
ORGUL members:         

Export aliases for DKFZP434L187 gene to outside databases

Previous GC identifers: GC15P026343 GC15M025417 GC15P028067 GC15U900230 GC15P028193 GC15P028275


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DKFZP434L187 Gene:
DKFZP434L187 is an RNA gene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  NT_187660.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DKFZP434L187 gene promoter:
         Pax-2   Pax-2a   Meis-1b   GATA-2   MZF-1   E2F-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DKFZP434L187


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.2   Ensembl cytogenetic band:  15q13.2   

DKFZP434L187 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DKFZP434L187 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P030488:  view genomic region     (about GC identifiers)

Start:
30,488,239 bp from pter      End:
30,506,743 bp from pter
Size:
18,505 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for DKFZP434L187:
 Increased G1 DNA content  Increased cell size 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DKFZP434L187
Interactions:

    Search GeneGlobe Interaction Network for DKFZP434L187

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for DKFZP434L187



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Unigene Cluster for DKFZP434L187:

Uncharacterized LOC26082
Hs.652128  [show with all ESTs]
Unigene Representative Sequence: NR_026771
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000562624(lincRNA)(uc010uax.2 uc001zds.2) ENST00000455163(lincRNA)
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Additional mRNA sequence: 

AK125576.1 AL117445.1 BC033224.1 BC130408.1 BC130410.1 DQ786280.1 NR_026771.1 

6 DOTS entries:

DT.121033441  DT.91873678  DT.101978234  DT.95086623  DT.121068796  DT.121033554 

21 AceView cDNA sequences:

F08364 BU625749 F04588 AL117445 AA127508 BC033224 BI114068 CA416646 
BI832005 AI241498 AK125576 AA127389 BV197846 BX283347 BV206520 AI368029 
BU162242 BI115143 AA889613 N83152 R99360 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for DKFZP434L187:none

DKFZP434L187 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGTTGGAAA
DKFZP434L187 Expression
About this image

DKFZP434L187 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DKFZP434L187 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.652128
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for DKFZP434L187 (if available)
TreeFam Gene Tree for DKFZP434L187 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DKFZP434L187 (see all 80)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs18099511,2
A--30486712(-) ACCCAA/GTCCTT 1 -- us2k12Minor allele frequency- G:0.25NA 4
rs23382281,2
--30486768(-) CCCACC/TGTGTT 1 -- us2k10--------
rs1865375921,2
--30486779(+) TCCCTA/GGAGAA 1 -- us2k10--------
rs773296381,2
--30486800(+) TGCTTC/TACCCA 1 -- us2k11Minor allele frequency- T:0.50NA 2
rs798547161,2
C,F--30487850(+) GGGGAC/TGGGGG 1 -- us2k12Minor allele frequency- T:0.00NA CSA 3
rs1831901761,2
--30487898(+) CAGCCC/TTTTCC 1 -- us2k10--------
rs1867638631,2
--30487994(+) GTCGGC/TTACAA 1 -- us2k10--------
rs1912766971,2
--30488428(+) TTCTCC/GCGCAA 1 -- int10--------
rs1826860251,2
C--30488572(+) AGGTGG/TGAGCC 1 -- int10--------
rs1883053371,2
--30488899(+) GGGGAG/TAAGAG 1 -- int10--------

HapMap Linkage Disequilibrium report for DKFZP434L187 (30488239 - 30506743 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for DKFZP434L187 (see all 30):    About this table    
Variant IDTypeSubtypePubMed ID
esv2421738CNV Duplication20811451
nsv509563CNV Insertion20534489
nsv100CNV Insertion15895083
nsv1475CNV Insertion18451855
nsv102CNV Insertion15895083
dgv2296n71CNV Loss21882294
dgv2297n71CNV Loss21882294
nsv471679CNV Loss15918152
nsv428300CNV Loss18775914
dgv2298n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for DKFZP434L187 gene integrated from 10 sources:
(articles sorted by number of sources associating them with DKFZP434L187)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26082 AceView: DKFZP434L187 Ensembl:ENSG00000225930 euGenes: HUgn26082

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DKFZP434L187 gene:
Search GeneIP for patents involving DKFZP434L187

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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