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Aliases for DIXDC1 Gene

Aliases for DIXDC1 Gene

  • DIX Domain Containing 1 2 3
  • Coiled-Coil Protein DIX1 3 4
  • CCD1 3 4
  • DIX Domain-Containing Protein 1 4
  • Coiled-Coil-DIX1 4
  • KIAA1735 4
  • Dixin 3

External Ids for DIXDC1 Gene

Summaries for DIXDC1 Gene

Entrez Gene Summary for DIXDC1 Gene

  • The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for DIXDC1 Gene

DIXDC1 (DIX Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include actin binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is DVL2.

UniProtKB/Swiss-Prot for DIXDC1 Gene

  • Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.

Gene Wiki entry for DIXDC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIXDC1 Gene

Genomics for DIXDC1 Gene

Genomic Location for DIXDC1 Gene

111,927,144 bp from pter
112,022,650 bp from pter
95,507 bases
Plus strand

Genomic View for DIXDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIXDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIXDC1 Gene

Regulatory Elements for DIXDC1 Gene

Proteins for DIXDC1 Gene

  • Protein details for DIXDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1A5D8
    • E9PRV4
    • Q6P2J8
    • Q6PIK4
    • Q86SR7
    • Q8IVY4
    • Q96N69
    • Q9C0C8

    Protein attributes for DIXDC1 Gene

    683 amino acids
    Molecular mass:
    77478 Da
    Quaternary structure:
    • Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin.
    • Sequence=AAH35509.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH64479.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB21826.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71039.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DIXDC1 Gene

    Alternative splice isoforms for DIXDC1 Gene


neXtProt entry for DIXDC1 Gene

Proteomics data for DIXDC1 Gene at MOPED

Post-translational modifications for DIXDC1 Gene

  • Phosphorylated on tyrosine and serine residues.
  • Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIXDC1 Gene

No data available for DME Specific Peptides for DIXDC1 Gene

Domains for DIXDC1 Gene

Protein Domains for DIXDC1 Gene


  • The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.:
    • Q155Q3
  • The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling.:
    • Q155Q3
  • Contains 1 CH (calponin-homology) domain.:
    • Q155Q3
  • Contains 1 DIX domain.:
    • Q155Q3
  • Belongs to the DIXDC1 family.:
    • Q155Q3
genes like me logo Genes that share domains with DIXDC1: view

No data available for Gene Families for DIXDC1 Gene

Function for DIXDC1 Gene

Molecular function for DIXDC1 Gene

UniProtKB/Swiss-Prot Function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.

Gene Ontology (GO) - Molecular Function for DIXDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 20823832
GO:0019904 protein domain specific binding IEA --
GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA --
GO:0043015 gamma-tubulin binding IDA 19375513
genes like me logo Genes that share ontologies with DIXDC1: view

Phenotypes for DIXDC1 Gene

GenomeRNAi human phenotypes for DIXDC1:
genes like me logo Genes that share phenotypes with DIXDC1: view

miRNA for DIXDC1 Gene

miRTarBase miRNAs that target DIXDC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DIXDC1 Gene

Localization for DIXDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIXDC1 Gene

Cytoplasm, cytosol. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis.
Isoform 1: Cell junction, focal adhesion. Note=Associated with actin stress fiber at the filament ends.
Isoform 2: Cytoplasm.

Subcellular locations from

Jensen Localization Image for DIXDC1 Gene COMPARTMENTS Subcellular localization image for DIXDC1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DIXDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IDA 19375513
GO:0005925 focal adhesion IEA --
GO:0005938 cell cortex --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with DIXDC1: view

Pathways for DIXDC1 Gene

SuperPathways for DIXDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIXDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0021695 cerebellar cortex development IEA --
GO:0021795 cerebral cortex cell migration --
GO:0021799 cerebral cortex radially oriented cell migration IEA --
genes like me logo Genes that share ontologies with DIXDC1: view

No data available for Pathways by source for DIXDC1 Gene

Transcripts for DIXDC1 Gene

Unigene Clusters for DIXDC1 Gene

DIX domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIXDC1 Gene

No ASD Table

Relevant External Links for DIXDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIXDC1 Gene

mRNA expression in normal human tissues for DIXDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIXDC1 Gene

SOURCE GeneReport for Unigene cluster for DIXDC1 Gene Hs.655626

mRNA Expression by UniProt/SwissProt for DIXDC1 Gene

Tissue specificity: Ubiquitously expressed with higher expression in cardiac and skeletal muscles.
genes like me logo Genes that share expressions with DIXDC1: view

Orthologs for DIXDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIXDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIXDC1 36
  • 99.51 (n)
  • 99.27 (a)
  • 99 (a)
(Bos Taurus)
Mammalia DIXDC1 36
  • 91.36 (n)
  • 93.27 (a)
  • 91 (a)
(Canis familiaris)
Mammalia DIXDC1 36
  • 93.17 (n)
  • 95.31 (a)
  • 91 (a)
(Mus musculus)
Mammalia Dixdc1 36
  • 88.68 (n)
  • 91.51 (a)
Dixdc1 16
Dixdc1 37
  • 88 (a)
(Monodelphis domestica)
Mammalia DIXDC1 37
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 58 (a)
-- 37
  • 71 (a)
(Rattus norvegicus)
Mammalia Dixdc1 36
  • 88.75 (n)
  • 92.16 (a)
(Gallus gallus)
Aves DIXDC1 36
  • 77.32 (n)
  • 80.79 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia DIXDC1 37
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dixdc1 36
  • 68.88 (n)
  • 68.88 (a)
(Danio rerio)
Actinopterygii dixdc1a 37
  • 58 (a)
dixdc1b 36
  • 64.23 (n)
  • 63.58 (a)
dixdc1b 37
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta dsh 37
  • 11 (a)
(Caenorhabditis elegans)
Secernentea dsh-1 37
  • 10 (a)
dsh-2 37
  • 9 (a)
mig-5 37
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
CSA.5831 37
  • 32 (a)
Species with no ortholog for DIXDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIXDC1 Gene

Gene Tree for DIXDC1 (if available)
Gene Tree for DIXDC1 (if available)

Paralogs for DIXDC1 Gene

Paralogs for DIXDC1 Gene

Selected SIMAP similar genes for DIXDC1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DIXDC1: view

Variants for DIXDC1 Gene

Sequence variations from dbSNP and Humsavar for DIXDC1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs476581 -- 112,018,930(-) CCACA(A/G)TGAAA intron-variant
rs476694 -- 112,000,788(-) gtaaa(A/C/G/T)tggta intron-variant
rs479658 -- 111,985,688(-) CAGGT(G/T)AATGT intron-variant
rs489417 -- 111,990,466(-) GTATA(C/T)TACCA intron-variant
rs491535 -- 111,949,758(+) AGATA(C/G)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIXDC1 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV Deletion 23290073
esv2662119 CNV Deletion 23128226

Relevant External Links for DIXDC1 Gene

HapMap Linkage Disequilibrium report

Disorders for DIXDC1 Gene

(1) Novoseek inferred disease relationships for DIXDC1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 8.08 1
genes like me logo Genes that share disorders with DIXDC1: view

No data available for UniProtKB/Swiss-Prot for DIXDC1 Gene

Publications for DIXDC1 Gene

  1. KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain. (PMID: 12792787) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  2. DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. (PMID: 16814745) Wang X. … Liu W. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293 cells. (PMID: 19375513) Wu Y. … Fan M. (Cell Biol. Int. 2009) 3 4 23
  4. Wnt signaling stabilizes the DIXDC1 protein through decreased ubiquitin-dependent degradation. (PMID: 20085589) Wang L. … Zheng L. (Cancer Sci. 2010) 3 4 23
  5. A novel monoclonal antibody specific to DIXDC1 protein. (PMID: 19519246) Liu T. … Zhu H. (Hybridoma (Larchmt) 2009) 3 23

Products for DIXDC1 Gene

  • antibodies-online proteins for DIXDC1
  • antibodies-online antibodies for DIXDC1
  • antibodies-online kits for DIXDC1

Sources for DIXDC1 Gene

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