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DIXDC1 Gene

protein-coding   GIFtS: 56
GCID: GC11P111797

DIX Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DIX Domain Containing 11 2     Coiled-coil-DIX13
Coiled-Coil Protein DIX12 3     KIAA17353
CCD12 3     DIX Domain-Containing Protein 13
dixin2     

External Ids:    HGNC: 236951   Entrez Gene: 854582   Ensembl: ENSG000001507647   OMIM: 6104935   UniProtKB: Q155Q33   

Export aliases for DIXDC1 gene to outside databases

Previous GC identifers: GC11P111385 GC11P111353 GC11P111807 GC11P107731


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DIXDC1 Gene:
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is
found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript
variants encoding different isoforms. (provided by RefSeq, Jun 2013)

GeneCards Summary for DIXDC1 Gene:
DIXDC1 (DIX domain containing 1) is a protein-coding gene. GO annotations related to this gene include actin binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is DVL1.

UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3
Function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK
activation by AXIN1 and DVL2

Gene Wiki entry for DIXDC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DIXDC1 gene promoter:
         AREB6   ER-alpha   RFX1   NF-1   Sp1   HFH-1   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DIXDC1 promoter sequence
   Search Chromatin IP Primers for DIXDC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DIXDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

DIXDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIXDC1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111797:  view genomic region     (about GC identifiers)

Start:
111,797,868 bp from pter      End:
111,893,308 bp from pter
Size:
95,441 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3 (See protein sequence)
Recommended Name: Dixin  
Size: 683 amino acids; 77478 Da
Subunit: Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac.
Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1.
Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin
Sequence caution: Sequence=AAH35509.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH64479.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB21826.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB71039.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
1 PDB 3D structure from and Proteopedia for DIXDC1:
3PZ7 (3D)    
Secondary accessions: A1A5D8 Q6P2J8 Q6PIK4 Q8IVY4 Q96N69 Q9C0C8
Alternative splicing: 3 isoforms:  Q155Q3-1   Q155Q3-2   Q155Q3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DIXDC1: NX_Q155Q3

Explore proteomics data for DIXDC1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine and serine residues1
  • Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by
    inhibiting its ubiquitination and subsequent degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DIXDC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001033043.1  NP_001265471.1  NP_219493.1  

    ENSEMBL proteins: 
     ENSP00000434130   ENSP00000432959   ENSP00000394352   ENSP00000314068  

    DIXDC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DIXDC1

     
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    antibodies-online proteins for DIXDC1 (4 products) 

     
    Search antibodies-online for peptides for DIXDC1

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    antibodies-online antibodies for DIXDC1 (17 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001158 DIX
     IPR001715 CH-domain
     IPR015506 Dsh/Dvl-rel

    Graphical View of Domain Structure for InterPro Entry Q155Q3

    ProtoNet protein and cluster: Q155Q3

    UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3
    Domain: The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation
    through MAP3K4
    Domain: The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through
    MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling
    Similarity: Belongs to the DIXDC1 family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DIX domain


    Find genes that share domains with DIXDC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DIXC1_HUMAN, Q155Q3
    Function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK
    activation by AXIN1 and DVL2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding ----
    GO:0031435mitogen-activated protein kinase kinase kinase binding IBA--
         
    Find genes that share ontologies with DIXDC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DIXDC1:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Dixdc1 (no phenotypes)

    Find genes that share phenotypes with DIXDC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dixdc1tm1(KOMP)Vlcg for DIXDC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DIXDC1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DIXDC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DIXDC1

    miRNA
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    miRTarBase miRNAs that target DIXDC1:
    hsa-mir-16-5p (MIRT051092), hsa-mir-615-3p (MIRT016151)

    Block miRNA regulation of human, mouse, rat DIXDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DIXDC1 (see all 96):
    hsa-miR-582-3p hsa-miR-100* hsa-miR-607 hsa-miR-15a hsa-miR-200a hsa-miR-1260b hsa-miR-3653 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidDIXDC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DIXDC1

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    Sino Biological Human cDNA Clone for DIXDC1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DIXC1_HUMAN, Q155Q3: Cytoplasm, cytosol. Note=Colocalizes with gamma-tubulin at the centrosome, both during
    interphase and mitosis
    DIXC1_HUMAN, Q155Q3: Isoform 1: Cell junction, focal adhesion. Note=Associated with actin stress fiber at the
    filament ends
    DIXC1_HUMAN, Q155Q3: Isoform 2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA19375513
    GO:0005925focal adhesion IEA--
    GO:0005938cell cortex IBA--

    Find genes that share ontologies with DIXDC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DIXDC1: 
              WNT Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DIXDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DIXDC1 (Q155Q31, 2, 3 ENSP000003943524) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2O146411, 2, 3, ENSP000000053404EBI-1104700,EBI-740850 MINT-8081452 MINT-8080344 I2D: score=1 STRING: ENSP00000005340
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    MAP3K4Q9Y6R43, ENSP000003759864I2D: score=1 STRING: ENSP00000375986
    PLK1P533502, ENSP000003000934MINT-8081452 STRING: ENSP00000300093
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle ----
    GO:0007275multicellular organismal development ----
    GO:0021695cerebellar cortex development IBA--
    GO:0021795cerebral cortex cell migration ----
    GO:0021799cerebral cortex radially oriented cell migration ----

    Find genes that share ontologies with DIXDC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DIXDC1 (DIXC1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DIXDC1 gene (3 alternative transcripts): 
    NM_001037954.3  NM_001278542.1  NM_033425.4  

    Unigene Cluster for DIXDC1:

    DIX domain containing 1
    Hs.655626  [show with all ESTs]
    Unigene Representative Sequence: NM_001037954
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529225(uc001pmj.3 uc001pmk.3) ENST00000389821(uc001pml.3 uc001pmn.3 uc010rwq.2)
    ENST00000528399 ENST00000531396 ENST00000524385 ENST00000530411 ENST00000524609
    ENST00000526500 ENST00000530645 ENST00000526418 ENST00000440460 ENST00000315253(uc001pmm.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat DIXDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DIXDC1 (see all 96):
    hsa-miR-582-3p hsa-miR-100* hsa-miR-607 hsa-miR-15a hsa-miR-200a hsa-miR-1260b hsa-miR-3653 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidDIXDC1 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DIXDC1 (NM_033425)
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      QuantiFast Probe-based Assays in human, mouse, rat DIXDC1

    Additional mRNA sequence: 

    AB051522.1 AB074187.1 AF070621.1 AK055469.1 AK055899.1 AK074277.1 AK289807.1 AK294954.1 
    BC033034.2 BC035509.2 BC041626.1 BC048294.1 BC064479.1 BC128600.1 DQ642016.1 NR_075084.1 

    8 DOTS entries:

    DT.421644  DT.102827990  DT.95159088  DT.95198090  DT.40215322  DT.99973653  DT.40120295  DT.429854 

    Selected AceView cDNA sequences (see all 108):

    CA425529 Z42616 CA428842 AF070621 BU149380 BM986812 AI589582 BC048294 
    BQ933587 AA234594 H15487 AA455092 BM674938 CA428835 BU735863 CA428843 
    BQ955625 CD519516 BC041626 BX506478 AL044001 BI914728 BM717744 BU631947 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DIXDC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGAACAG
    DIXDC1 Expression
    About this image


    DIXDC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Osteochondro Mesenchymal Cells Rib
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Osteochondro Mesenchymal Cells Rib
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Primitive Streak Cells Primitive Streak
             Primitive Streak
     
     Head Mesenchyme (Muscoskeletal System)
             Head Mesenchyme
     
     Somite (Muscoskeletal System)
             Thoracic Mesenchymal Sclerotome
    DIXDC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DIXDC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655626

    UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3
    Tissue specificity: Ubiquitously expressed with higher expression in cardiac and skeletal muscles

        Pathway & Disease-focused RT2 Profiler PCR Array including DIXDC1: 
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIXDC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DIXDC1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dixdc11 , 5 DIX domain containing 11, 5 88.68(n)1
    91.51(a)1
      9 (27.75 cM)5
    3309381  NM_178118.21  NP_835219.11 
     506627525 
    chicken
    (Gallus gallus)
    Aves DIXDC11 DIX domain containing 1 77.32(n)
    80.79(a)
      419798  XM_417934.4  XP_417934.3 
    lizard
    (Anolis carolinensis)
    Reptilia DIXDC16
    DIX domain containing 1
    72(a)
    1 ↔ 1
    AAWZ02035514(4456-15482)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dixdc11 DIX domain containing 1 68.88(n)
    68.88(a)
      100497786  XM_002932938.2  XP_002932984.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dixdc1b1 DIX domain containing 1b 64.23(n)
    63.58(a)
      794716  XM_001919788.4  XP_001919823.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta dsh6
    dishevelled
    11(a)
    1 → many
    X(11249914-11252757)
    worm
    (Caenorhabditis elegans)
    Secernentea dsh-26
    dsh-16
    (see all 3)
    Protein DSH-2 (dsh-2) mRNA, complete cds
    Protein DSH-1, isoform c (dsh-1) mRNA, complete cd...
    (see all 3)
    9(a)
    10(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(5078210-5081161) WBGene00001102
    II(5214441-5225373) WBGene00001101


    ENSEMBL Gene Tree for DIXDC1 (if available)
    TreeFam Gene Tree for DIXDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DIXDC1 gene
    DVL12  DVL22  DVL32  
    1 SIMAP similar gene for DIXDC1 using alignment to 5 protein entries:     DIXC1_HUMAN (see all proteins):
    ACTN1

    Find genes that share paralogs with DIXDC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DIXDC1 (see all 1694)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717007471,2
    C--107722700(+) TCTCA-/A/AAA 
            
    AAAAA
    1 -- int10--------
    rs113973761,2
    C--107782355(+) TTTTTT/-GAGAC 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1382661931,2
    C--107798549(+) GTCTC-/AAAAAA 2 -- int10--------
    rs593509971,2
    C--107798559(+) AAAAA-/AGGAGA 2 -- int10--------
    rs722556731,2
    C--107798778(+) AAAAT-/TATATAT 2 -- int10--------
    rs1429397801,2
    C--107798778(+) AAAAT-/TATATA
            
    TATAT
    2 -- int10--------
    rs1900761661,2
    --107808063(+) CGGGTC/TGGGGG 2 -- int10--------
    rs2019192391,2
    --107808066(+) GTCGG-/GGGG  
     TGGGGGT
    GGGGT
    2 -- int10--------
    rs2005731611,2
    --107808075(+) TGGGG-/GTGGGGT 2 -- int10--------
    rs1117509511,2
    C,F--111659305(+) AAGTTC/TACAAG 1 -- us2k12Minor allele frequency- T:0.21CSA WA 120

    HapMap Linkage Disequilibrium report for DIXDC1 (111797868 - 111893308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DIXDC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745077CNV Deletion23290073
    esv2662119CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DIXDC1
    DNA2.0 Custom Variant and Variant Library Synthesis for DIXDC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610493    OMIM disorders: --


    Find genes that share disorders with DIXDC1           About GenesLikeMe

    1 Novoseek inferred disease relationship for DIXDC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 8.08 1 12792787 (1)


    Export disorders for DIXDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DIXDC1 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DIXDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Wnt signaling stabilizes the DIXDC1 protein through decreased ubiquitin-dependent degradation. (PubMed id 20085589)1, 2, 9 Wang L.... Zheng L. (Cancer Sci. 2010)
    2. KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain. (PubMed id 12792787)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    3. DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293 cells. (PubMed id 19375513)1, 2, 9 Wu Y.... Fan M. (Cell Biol. Int. 2009)
    4. DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. (PubMed id 16814745)1, 2, 9 Wang X.... Liu W. (Biochem. Biophys. Res. Commun. 2006)
    5. Molecular basis of Wnt activation via the DIX-domain protein Ccd1. (PubMed id 21189423)1, 2 Liu Y.T.... Wu J.W. (J. Biol. Chem. 2011)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PubMed id 15262978)1, 2 Wong C.K.... Lin S.-C. (J. Biol. Chem. 2004)
    8. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation. (PubMed id 19572978)1, 9 Wang L....Zheng L. (Cancer Sci. 2009)
    10. DIXDC1 promotes retinoic acid-induced neuronal differentiation and inhibits gliogenesis in P19 cells. (PubMed id 18629627)1, 9 Jing X.T....Fan M. (Cell. Mol. Neurobiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85458 HGNC: 23695 AceView: DIXDC1 Ensembl:ENSG00000150764 euGenes: HUgn85458
    ECgene: DIXDC1 H-InvDB: DIXDC1

    (According to HUGE)
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    HUGE: KIAA1735

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DIXDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DIXDC1 gene:
    Search GeneIP for patents involving DIXDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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