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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DIXDC1 Gene

protein-coding   GIFtS: 56
GCID: GC11P111797

DIX Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DIX Domain Containing 11 2     Coiled-coil-DIX13
Coiled-Coil Protein DIX12 3     KIAA17353
CCD12 3     DIX Domain-Containing Protein 13
dixin2     

External Ids:    HGNC: 236951   Entrez Gene: 854582   Ensembl: ENSG000001507647   OMIM: 6104935   UniProtKB: Q155Q33   

Export aliases for DIXDC1 gene to outside databases

Previous GC identifers: GC11P111385 GC11P111353 GC11P111807 GC11P107731


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DIXDC1 Gene:
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is
found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript
variants encoding different isoforms. (provided by RefSeq, Jun 2013)

GeneCards Summary for DIXDC1 Gene: 
DIXDC1 (DIX domain containing 1) is a protein-coding gene. Diseases associated with DIXDC1 include neuroblastoma, and schizophrenia. GO annotations related to this gene include actin binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is DVL1.

UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3
Function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK
activation by AXIN1 and DVL2

Gene Wiki entry for DIXDC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DIXDC1 gene promoter:
         AREB6   ER-alpha   RFX1   NF-1   Sp1   HFH-1   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DIXDC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DIXDC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIXDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

DIXDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIXDC1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111797:  view genomic region     (about GC identifiers)

Start:
111,797,868 bp from pter      End:
111,893,308 bp from pter
Size:
95,441 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3 (See protein sequence)
Recommended Name: Dixin  
Size: 683 amino acids; 77478 Da
Subunit: Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac.
Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1.
Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin
Subcellular location: Cytoplasm, cytosol. Note=Colocalizes with gamma-tubulin at the centrosome, both during
interphase and mitosis
Subcellular location: Isoform 1: Cell junction, focal adhesion. Note=Associated with actin stress fiber at the
filament ends
Subcellular location: Isoform 2: Cytoplasm
Sequence caution: Sequence=AAH35509.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH64479.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB21826.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB71039.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
1 PDB 3D structure from and Proteopedia for DIXDC1:
3PZ7 (3D)    
Secondary accessions: A1A5D8 Q6P2J8 Q6PIK4 Q8IVY4 Q96N69 Q9C0C8
Alternative splicing: 3 isoforms:  Q155Q3-1   Q155Q3-2   Q155Q3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DIXDC1: NX_Q155Q3

Explore proteomics data for DIXDC1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine and serine residues
  • UniProtKB: Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by
    inhibiting its ubiquitination and subsequent degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q155Q3

  • DIXDC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DIXDC1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001033043.1  NP_001265471.1  NP_219493.1  

    ENSEMBL proteins: 
     ENSP00000434130   ENSP00000432959   ENSP00000394352   ENSP00000314068  

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    Cloud-Clone Corp. Proteins for DIXDC1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA19375513
    GO:0005925focal adhesion IEA--
    GO:0005938cell cortex IBA--

    DIXDC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001158 DIX
     IPR001715 CH-domain
     IPR015506 Dsh/Dvl-rel

    Graphical View of Domain Structure for InterPro Entry Q155Q3

    ProtoNet protein and cluster: Q155Q3

    UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3
    Domain: The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation
    through MAP3K4
    Domain: The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through
    MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling
    Similarity: Belongs to the DIXDC1 family
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DIX domain


    DIXDC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DIXC1_HUMAN, Q155Q3
    Function: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK
    activation by AXIN1 and DVL2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI--
    GO:0019904protein domain specific binding ----
    GO:0031435mitogen-activated protein kinase kinase kinase binding IBA--
         
    DIXDC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DIXDC1:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Dixdc1 (no phenotypes)

    DIXDC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dixdc1tm1(KOMP)Vlcg for DIXDC1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DIXDC1 
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    hsa-miR-582-3p hsa-miR-100* hsa-miR-607 hsa-miR-15a hsa-miR-200a hsa-miR-1260b hsa-miR-3653 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidDIXDC1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIXDC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DIXDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for DIXDC1 (Q155Q31, 2, 3 ENSP000003943524) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2O146412, 3, ENSP000000053404MINT-8081452 MINT-8080344 I2D: score=1 STRING: ENSP00000005340
    NDEL1Q9GZM83, ENSP000003339824I2D: score=2 STRING: ENSP00000333982
    MAP3K4Q9Y6R43, ENSP000003759864I2D: score=1 STRING: ENSP00000375986
    AXIN1O151693, ENSP000002623204I2D: score=2 STRING: ENSP00000262320
    PLK1P533502, ENSP000003000934MINT-8081452 STRING: ENSP00000300093
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle ----
    GO:0007275multicellular organismal development ----
    GO:0021695cerebellar cortex development IBA--
    GO:0021795cerebral cortex cell migration ----
    GO:0021799cerebral cortex radially oriented cell migration ----

    DIXDC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DIXDC1 (DIXC1)

    Search CenterWatch for drugs/clinical trials and news about DIXDC1 / DIXC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DIXDC1 gene (3 alternative transcripts): 
    NM_001037954.3  NM_001278542.1  NM_033425.4  

    Unigene Cluster for DIXDC1:

    DIX domain containing 1
    Hs.655626  [show with all ESTs]
    Unigene Representative Sequence: NM_001037954
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529225(uc001pmj.3 uc001pmk.3) ENST00000389821(uc001pml.3 uc001pmn.3 uc010rwq.2)
    ENST00000528399 ENST00000531396 ENST00000524385 ENST00000530411 ENST00000524609
    ENST00000526500 ENST00000530645 ENST00000526418 ENST00000440460 ENST00000315253(uc001pmm.3)

    miRNA
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    hsa-miR-582-3p hsa-miR-100* hsa-miR-607 hsa-miR-15a hsa-miR-200a hsa-miR-1260b hsa-miR-3653 hsa-miR-3142
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    Additional mRNA sequence: 

    AB051522.1 AB074187.1 AF070621.1 AK055469.1 AK055899.1 AK074277.1 AK289807.1 AK294954.1 
    BC033034.2 BC035509.2 BC041626.1 BC048294.1 BC064479.1 BC128600.1 DQ642016.1 NR_075084.1 

    8 DOTS entries:

    DT.421644  DT.102827990  DT.95159088  DT.95198090  DT.40215322  DT.99973653  DT.40120295  DT.429854 

    24/108 AceView cDNA sequences (see all 108):

    CA425529 Z42616 CA428842 AF070621 BU149380 BM986812 AI589582 BC048294 
    BQ933587 AA234594 H15487 AA455092 BM674938 CA428835 BU735863 CA428843 
    BQ955625 CD519516 BC041626 BX506478 AL044001 BI914728 BM717744 BU631947 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DIXDC1 expression in normal human tissues (normalized intensities)      DIXDC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGAACAG
    DIXDC1 Expression
    About this image


    DIXDC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Thoracic Proximal Rib
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Thoracic Proximal Rib
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Primitive Streak Cells Primitive Streak
             Primitive Streak
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Head Mesenchyme (Muscoskeletal System)
             Head Mesenchyme

    See DIXDC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DIXDC1

    SOURCE GeneReport for Unigene cluster: Hs.655626

    UniProtKB/Swiss-Prot: DIXC1_HUMAN, Q155Q3
    Tissue specificity: Ubiquitously expressed with higher expression in cardiac and skeletal muscles

        SABiosciences Expression via Pathway-Focused PCR Array including DIXDC1: 
              WNT Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DIXDC1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dixdc11 , 5 DIX domain containing 11, 5 88.68(n)1
    91.51(a)1
      9 (27.75 cM)5
    3309381  NM_178118.21  NP_835219.11 
     506627525 
    chicken
    (Gallus gallus)
    Aves DIXDC11 DIX domain containing 1 77.32(n)
    80.79(a)
      419798  XM_417934.3  XP_417934.3 
    lizard
    (Anolis carolinensis)
    Reptilia DIXDC16
    Uncharacterized protein
    71(a)
    1 ↔ 1
    AAWZ02035514(4456-15482)
    zebrafish
    (Danio rerio)
    Actinopterygii dixdc1b1 DIX domain containing 1b 64.18(n)
    63.88(a)
      794716  XM_001919788.3  XP_001919823.2 


    ENSEMBL Gene Tree for DIXDC1 (if available)
    TreeFam Gene Tree for DIXDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DIXDC1 gene
    DVL12  DVL22  DVL32  
    1 SIMAP similar gene for DIXDC1 using alignment to 5 protein entries:     DIXC1_HUMAN (see all proteins):
    ACTN1

    DIXDC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1694 SNPs in DIXDC1 are shown (see all 1694)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717007471,2
    C--107722700(+) TCTCA-/A/AAA 
            
    AAAAA
    1 -- int10--------
    rs113973761,2
    C--107782355(+) TTTTTT/-GAGAC 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1382661931,2
    C--107798549(+) GTCTC-/AAAAAA 2 -- int10--------
    rs593509971,2
    C--107798559(+) AAAAA-/AGGAGA 2 -- int10--------
    rs722556731,2
    C--107798778(+) AAAAT-/TATATAT 2 -- int10--------
    rs1429397801,2
    C--107798778(+) AAAAT-/TATATA
            
    TATAT
    2 -- int10--------
    rs1900761661,2
    --107808063(+) CGGGTC/TGGGGG 2 -- int10--------
    rs2019192391,2
    --107808066(+) GTCGG-/GGGG  
     TGGGGGT
    GGGGT
    2 -- int10--------
    rs2005731611,2
    --107808075(+) TGGGG-/GTGGGGT 2 -- int10--------
    rs1117509511,2
    C,F--111659305(+) AAGTTC/TACAAG 1 -- us2k12Minor allele frequency- T:0.21CSA WA 120

    HapMap Linkage Disequilibrium report for DIXDC1 (111797868 - 111893308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DIXDC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745077CNV Deletion23290073
    esv2662119CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610493    OMIM disorders: --

    5 diseases for DIXDC1:    About MalaCards
    neuroblastoma    schizophrenia    colon cancer    cerebritis
    neuronitis


    DIXDC1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DIXDC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 8.08 1 12792787 (1)


    Export disorders for DIXDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DIXDC1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with DIXDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Wnt signaling stabilizes the DIXDC1 protein through d ecreased ubiquitin-dependent degradation. (PubMed id 20085589)1, 2, 9 Wang L....Zheng L. (2010)
    2. KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain. (PubMed id 12792787)1, 3, 9 Katoh M. and Katoh M. (2003)
    3. DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293 cells. (PubMed id 19375513)1, 2, 9 Wu Y....Fan M. (2009)
    4. DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. (PubMed id 16814745)1, 2, 9 Wang X.... Liu W. (2006)
    5. Molecular basis of Wnt activation via the DIX-domain protein Ccd1. (PubMed id 21189423)1, 2 Liu Y.T.... Wu J.W. (2011)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PubMed id 15262978)1, 2 Wong C.K.... Lin S.-C. (2004)
    8. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    9. DIXDC1 targets p21 and cyclin D1 via PI3K pathway act ivation to promote colon cancer cell proliferation. (PubMed id 19572978)1, 9 Wang L....Zheng L. (2009)
    10. DIXDC1 promotes retinoic acid-induced neuronal differentiation and inhibits gliogenesis in P19 cells. (PubMed id 18629627)1, 9 Jing X.T....Fan M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85458 HGNC: 23695 AceView: DIXDC1 Ensembl:ENSG00000150764 euGenes: HUgn85458
    ECgene: DIXDC1 H-InvDB: DIXDC1

    (According to HUGE)
    About This Section
    HUGE: KIAA1735

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DIXDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DIXDC1 gene:
    Search GeneIP for patents involving DIXDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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