Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DIXDC1 Gene

Aliases for DIXDC1 Gene

  • DIX Domain Containing 1 2 3 5
  • Coiled-Coil Protein DIX1 3 4
  • CCD1 3 4
  • DIX Domain-Containing Protein 1 4
  • Coiled-Coil-DIX1 4
  • KIAA1735 4
  • Dixin 3

External Ids for DIXDC1 Gene

Previous GeneCards Identifiers for DIXDC1 Gene

  • GC11P111385
  • GC11P111353
  • GC11P111807
  • GC11P107731
  • GC11P111797

Summaries for DIXDC1 Gene

Entrez Gene Summary for DIXDC1 Gene

  • The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

GeneCards Summary for DIXDC1 Gene

DIXDC1 (DIX Domain Containing 1) is a Protein Coding gene. Among its related pathways are Adhesion and Wnt / Hedgehog / Notch. GO annotations related to this gene include actin binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is MIR6808.

UniProtKB/Swiss-Prot for DIXDC1 Gene

  • Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.

Gene Wiki entry for DIXDC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIXDC1 Gene

Genomics for DIXDC1 Gene

Regulatory Elements for DIXDC1 Gene

Enhancers for DIXDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F111949 0.5 Ensembl ENCODE 12.4 +22.5 22470 0.8 ARID1B ZFHX2 IKZF1 DPF2 ZNF584 NR2F6 NR2F2 EGR2 RNA5SP351 DIXDC1 CRYAB C11orf52 HSPB2 HSPB2-C11orf52 ENSG00000255292 SDHD TIMM8B PPP2R1B
GH11F111981 0.9 Ensembl ENCODE 11.8 +55.8 55758 2.9 HDAC1 WRNIP1 ARID4B RAD21 YY1 CREM REST POLR2H MAFF SMARCA4 RNA5SP351 DIXDC1 CRYAB C11orf52 HSPB2 HSPB2-C11orf52 PPP2R1B ENSG00000255334 ENSG00000255286
GH11F112023 1.1 ENCODE 11 +98.0 97983 2.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PPP2R1B C11orf57 PIH1D2 DIXDC1 RPS6P16 CRYAB C11orf52 DLAT GC11M112030
GH11F111870 0.5 ENCODE 10.8 -55.8 -55822 2.2 HDGF ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 PPP2R1B DIXDC1 HSPB2 HSPB2-C11orf52 C11orf52 CRYAB C11orf57 PIH1D2 ALG9 GC11P111865
GH11F111877 0.2 ENCODE 10.7 -49.3 -49293 0.1 BCOR SCRT1 CEBPB ZIC2 MEF2D SMARCA4 POLR2A SCRT2 ZBTB33 KDM1A C11orf52 CRYAB DIXDC1 C11orf57 PIH1D2 HSPB2 HSPB2-C11orf52 PPP2R1B ENSG00000255292 C11orf1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DIXDC1 on UCSC Golden Path with GeneCards custom track

Promoters for DIXDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190223 56 1201 HDGF ZFP64 SIN3A ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 CBX5 ZNF143

Genomic Location for DIXDC1 Gene

Chromosome:
11
Start:
111,927,144 bp from pter
End:
112,022,650 bp from pter
Size:
95,507 bases
Orientation:
Plus strand

Genomic View for DIXDC1 Gene

Genes around DIXDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIXDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIXDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIXDC1 Gene

Proteins for DIXDC1 Gene

  • Protein details for DIXDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q155Q3-DIXC1_HUMAN
    Recommended name:
    Dixin
    Protein Accession:
    Q155Q3
    Secondary Accessions:
    • A1A5D8
    • E9PRV4
    • Q6P2J8
    • Q6PIK4
    • Q86SR7
    • Q8IVY4
    • Q96N69
    • Q9C0C8

    Protein attributes for DIXDC1 Gene

    Size:
    683 amino acids
    Molecular mass:
    77478 Da
    Quaternary structure:
    • Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin.
    SequenceCaution:
    • Sequence=AAH35509.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH64479.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB21826.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB71039.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DIXDC1 Gene

    Alternative splice isoforms for DIXDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DIXDC1 Gene

Post-translational modifications for DIXDC1 Gene

  • Phosphorylated on tyrosine and serine residues.
  • Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DIXDC1 Gene

Domains & Families for DIXDC1 Gene

Gene Families for DIXDC1 Gene

Protein Domains for DIXDC1 Gene

Suggested Antigen Peptide Sequences for DIXDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q155Q3

UniProtKB/Swiss-Prot:

DIXC1_HUMAN :
  • The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.
  • Belongs to the DIXDC1 family.
Domain:
  • The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.
  • The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 DIX domain.
Family:
  • Belongs to the DIXDC1 family.
genes like me logo Genes that share domains with DIXDC1: view

Function for DIXDC1 Gene

Molecular function for DIXDC1 Gene

UniProtKB/Swiss-Prot Function:
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.

Gene Ontology (GO) - Molecular Function for DIXDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 20823832
GO:0019904 protein domain specific binding IEA --
GO:0043015 gamma-tubulin binding IDA 19375513
genes like me logo Genes that share ontologies with DIXDC1: view
genes like me logo Genes that share phenotypes with DIXDC1: view

Animal Models for DIXDC1 Gene

MGI Knock Outs for DIXDC1:

Animal Model Products

miRNA for DIXDC1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DIXDC1 Gene

Localization for DIXDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIXDC1 Gene

Cytoplasm, cytosol. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis.
Isoform 1: Cell junction, focal adhesion. Note=Associated with actin stress fiber at the filament ends.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIXDC1 Gene COMPARTMENTS Subcellular localization image for DIXDC1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DIXDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA,IDA 19375513
GO:0005925 focal adhesion IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DIXDC1: view

Pathways & Interactions for DIXDC1 Gene

genes like me logo Genes that share pathways with DIXDC1: view

Pathways by source for DIXDC1 Gene

3 Cell Signaling Technology pathways for DIXDC1 Gene

Gene Ontology (GO) - Biological Process for DIXDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0021795 cerebral cortex cell migration IEA --
GO:0021799 cerebral cortex radially oriented cell migration IEA --
genes like me logo Genes that share ontologies with DIXDC1: view

No data available for SIGNOR curated interactions for DIXDC1 Gene

Transcripts for DIXDC1 Gene

Unigene Clusters for DIXDC1 Gene

DIX domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIXDC1 Gene

No ASD Table

Relevant External Links for DIXDC1 Gene

GeneLoc Exon Structure for
DIXDC1
ECgene alternative splicing isoforms for
DIXDC1

Expression for DIXDC1 Gene

mRNA expression in normal human tissues for DIXDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DIXDC1 Gene

This gene is overexpressed in Lung (44.1), Placenta (15.2), and Fetal gut (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIXDC1 Gene



Protein tissue co-expression partners for DIXDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DIXDC1 Gene:

DIXDC1

SOURCE GeneReport for Unigene cluster for DIXDC1 Gene:

Hs.655626

mRNA Expression by UniProt/SwissProt for DIXDC1 Gene:

Q155Q3-DIXC1_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in cardiac and skeletal muscles.
genes like me logo Genes that share expression patterns with DIXDC1: view

Primer Products

No data available for mRNA differential expression in normal tissues for DIXDC1 Gene

Orthologs for DIXDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIXDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIXDC1 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia DIXDC1 34 35
  • 93.17 (n)
cow
(Bos Taurus)
Mammalia DIXDC1 34 35
  • 91.36 (n)
rat
(Rattus norvegicus)
Mammalia Dixdc1 34
  • 88.75 (n)
mouse
(Mus musculus)
Mammalia Dixdc1 34 16 35
  • 88.68 (n)
oppossum
(Monodelphis domestica)
Mammalia DIXDC1 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves DIXDC1 34 35
  • 77.32 (n)
lizard
(Anolis carolinensis)
Reptilia DIXDC1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dixdc1 34
  • 68.88 (n)
zebrafish
(Danio rerio)
Actinopterygii dixdc1b 34 35
  • 64.23 (n)
dixdc1a 35
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dsh 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dsh-1 35
  • 10 (a)
ManyToMany
mig-5 35
  • 10 (a)
ManyToMany
dsh-2 35
  • 9 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
CSA.5831 35
  • 32 (a)
OneToMany
Species where no ortholog for DIXDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIXDC1 Gene

ENSEMBL:
Gene Tree for DIXDC1 (if available)
TreeFam:
Gene Tree for DIXDC1 (if available)

Paralogs for DIXDC1 Gene

Paralogs for DIXDC1 Gene

(1) SIMAP similar genes for DIXDC1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DIXDC1: view

Variants for DIXDC1 Gene

Sequence variations from dbSNP and Humsavar for DIXDC1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10082686 -- 111,939,299(+) CTTTG(A/G)TGCTT intron-variant
rs10431066 -- 111,978,749(+) GGAAC(A/G)TGTCA intron-variant
rs10635444 -- 111,941,837(+) CACAC(-/AC/ACAC/ACACAC)CCACG intron-variant
rs10789853 -- 111,927,254(+) TGGAG(G/T)CGGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10789854 -- 111,983,141(+) GGAGC(C/G)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIXDC1 Gene

Variant ID Type Subtype PubMed ID
esv2662119 CNV deletion 23128226
esv2745077 CNV deletion 23290073
esv3627746 CNV loss 21293372
esv3627747 CNV loss 21293372
esv3627749 CNV loss 21293372
nsv1127232 CNV deletion 24896259

Variation tolerance for DIXDC1 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIXDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIXDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIXDC1 Gene

Disorders for DIXDC1 Gene

Relevant External Links for DIXDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIXDC1

No disorders were found for DIXDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIXDC1 Gene

Publications for DIXDC1 Gene

  1. Wnt signaling stabilizes the DIXDC1 protein through decreased ubiquitin-dependent degradation. (PMID: 20085589) Wang L. … Zheng L. (Cancer Sci. 2010) 3 4 22 64
  2. DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293 cells. (PMID: 19375513) Wu Y. … Fan M. (Cell Biol. Int. 2009) 3 4 22 64
  3. DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. (PMID: 16814745) Wang X. … Liu W. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 64
  4. KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain. (PMID: 12792787) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 22 64
  5. Molecular basis of Wnt activation via the DIX-domain protein Ccd1. (PMID: 21189423) Liu Y.T. … Wu J.W. (J. Biol. Chem. 2011) 3 4 64

Products for DIXDC1 Gene

Sources for DIXDC1 Gene

Content
Loading form....