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Aliases for DISP3 Gene

Aliases for DISP3 Gene

  • Dispatched RND Transporter Family Member 3 2 3
  • Patched Domain Containing 2 2 3 5
  • PTCHD2 3 4 5
  • Patched Domain-Containing Protein 2 3 4
  • Dispatched Homolog 3 (Drosophila) 2
  • Dispatched Homolog 3 3
  • Dispatched 3 3
  • KIAA1337 4

External Ids for DISP3 Gene

Previous HGNC Symbols for DISP3 Gene

  • PTCHD2

Summaries for DISP3 Gene

GeneCards Summary for DISP3 Gene

DISP3 (Dispatched RND Transporter Family Member 3) is a Protein Coding gene. An important paralog of this gene is DISP2.

UniProtKB/Swiss-Prot for DISP3 Gene

  • Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISP3 Gene

Genomics for DISP3 Gene

Regulatory Elements for DISP3 Gene

Enhancers for DISP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DISP3 on UCSC Golden Path with GeneCards custom track

Promoters for DISP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DISP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DISP3 Gene

Chromosome:
1
Start:
11,479,166 bp from pter
End:
11,537,584 bp from pter
Size:
58,419 bases
Orientation:
Plus strand

Genomic View for DISP3 Gene

Genes around DISP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DISP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DISP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISP3 Gene

Proteins for DISP3 Gene

  • Protein details for DISP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K9-DISP3_HUMAN
    Recommended name:
    Protein dispatched homolog 3
    Protein Accession:
    Q9P2K9
    Secondary Accessions:
    • Q5VTU9
    • Q9UJD6

    Protein attributes for DISP3 Gene

    Size:
    1392 amino acids
    Molecular mass:
    153048 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB55303.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70606.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22474.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DISP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DISP3 Gene

Proteomics data for DISP3 Gene at MOPED

Post-translational modifications for DISP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DISP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DISP3 Gene

Domains & Families for DISP3 Gene

Protein Domains for DISP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DISP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2K9

UniProtKB/Swiss-Prot:

DISP3_HUMAN :
  • The SSD (sterol-sensing) domain is necessary for the increase in cellular cholesterol uptake.
  • Belongs to the patched family.
Domain:
  • The SSD (sterol-sensing) domain is necessary for the increase in cellular cholesterol uptake.
  • Contains 1 SSD (sterol-sensing) domain.
Family:
  • Belongs to the patched family.
genes like me logo Genes that share domains with DISP3: view

No data available for Gene Families for DISP3 Gene

Function for DISP3 Gene

Molecular function for DISP3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by thyroid hormone T3 (PubMed:19179482).

Gene Ontology (GO) - Molecular Function for DISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008158 hedgehog receptor activity IEA --
genes like me logo Genes that share ontologies with DISP3: view

Phenotypes for DISP3 Gene

genes like me logo Genes that share phenotypes with DISP3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DISP3 Gene

Localization for DISP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISP3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Predominantly localized to cholesterol-enriched domains within the membrane (PubMed:19179482). Localizes to cytoplasmic punctate vesicular structures (By similarity). {ECO:0000250 UniProtKB:B9U3F2, ECO:0000269 PubMed:19179482}.

Gene Ontology (GO) - Cellular Components for DISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DISP3: view

No data available for Subcellular locations from COMPARTMENTS for DISP3 Gene

Pathways & Interactions for DISP3 Gene

SuperPathways for DISP3 Gene

No Data Available

Interacting Proteins for DISP3 Gene

Gene Ontology (GO) - Biological Process for DISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032368 regulation of lipid transport NAS 15645143
GO:0042632 cholesterol homeostasis ISS 19179482
GO:0045665 negative regulation of neuron differentiation IDA 25281927
genes like me logo Genes that share ontologies with DISP3: view

No data available for Pathways by source and SIGNOR curated interactions for DISP3 Gene

Drugs & Compounds for DISP3 Gene

No Compound Related Data Available

Transcripts for DISP3 Gene

mRNA/cDNA for DISP3 Gene

(9) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DISP3 Gene

No ASD Table

Relevant External Links for DISP3 Gene

GeneLoc Exon Structure for
DISP3
ECgene alternative splicing isoforms for
DISP3

Expression for DISP3 Gene

mRNA Expression by UniProt/SwissProt for DISP3 Gene

Q9P2K9-DISP3_HUMAN
Tissue specificity: Expressed in brain and testis (PubMed:15645143).

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DISP3 Gene

Orthologs for DISP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DISP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PTCHD2 35
  • 88.57 (n)
  • 91.37 (a)
PTCHD2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PTCHD2 35
  • 89.11 (n)
  • 91.09 (a)
PTCHD2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ptchd2 35
  • 86.34 (n)
  • 91.69 (a)
Ptchd2 16
Ptchd2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PTCHD2 35
  • 98.26 (n)
  • 98.31 (a)
PTCHD2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ptchd2 35
  • 86.5 (n)
  • 91.49 (a)
oppossum
(Monodelphis domestica)
Mammalia PTCHD2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PTCHD2 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PTCHD2 35
  • 76.9 (n)
  • 82.36 (a)
DISP3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PTCHD2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491297 35
  • 65.62 (n)
  • 73.48 (a)
zebrafish
(Danio rerio)
Actinopterygii ptchd2 35
  • 60.34 (n)
  • 58.03 (a)
PTCHD2 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta disp 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-14 36
  • 12 (a)
ManyToMany
ptd-2 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
OneToMany
Species with no ortholog for DISP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DISP3 Gene

ENSEMBL:
Gene Tree for DISP3 (if available)
TreeFam:
Gene Tree for DISP3 (if available)

Paralogs for DISP3 Gene

Paralogs for DISP3 Gene

genes like me logo Genes that share paralogs with DISP3: view

Variants for DISP3 Gene

Sequence variations from dbSNP and Humsavar for DISP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_036796 -
rs2817580 - 11,501,536(+) TCGGT(A/G)GCCCA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs2072994 - 11,519,413(-) GGGAG(C/T)GGCAA nc-transcript-variant, reference, missense
rs2072993 - 11,519,447(-) TGGGG(C/G)CCTGG nc-transcript-variant, reference, missense
rs12096312 - 11,529,600(+) CGGGC(A/G)CGTAT nc-transcript-variant, reference, missense

Variation tolerance for DISP3 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.96; 89.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DISP3 Gene

HapMap Linkage Disequilibrium report
DISP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DISP3 Gene

Disorders for DISP3 Gene

Relevant External Links for DISP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DISP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DISP3

No disorders were found for DISP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DISP3 Gene

Publications for DISP3 Gene

  1. DISP3 promotes proliferation and delays differentiation of neural progenitor cells. (PMID: 25281927) ZA-kovA! M. … BartA^nA9k P. (FEBS Lett. 2014) 2 3 4 67
  2. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. (PMID: 15738394) Peart M.J. … Johnstone R.W. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3
  3. Identification and characterization of DISP3 gene in silico. (PMID: 15645143) Katoh Y. … Katoh M. (Int. J. Oncol. 2005) 3 23
  4. Novel gene identified in an exome-wide association study of tanning dependence. (PMID: 25041255) Cartmel B. … Bale A.E. (Exp. Dermatol. 2014) 3
  5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3

Products for DISP3 Gene

Sources for DISP3 Gene

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