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Aliases for DISP2 Gene

Aliases for DISP2 Gene

  • Dispatched Homolog 2 (Drosophila) 2 3
  • DISPB 3 4 6
  • KIAA1742 4 6
  • Protein Dispatched Homolog 2 3
  • Dispatched B 3
  • HsT16908 3

External Ids for DISP2 Gene

Summaries for DISP2 Gene

Entrez Gene Summary for DISP2 Gene

  • The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched. [provided by RefSeq, Jul 2008]

GeneCards Summary for DISP2 Gene

DISP2 (Dispatched Homolog 2 (Drosophila)) is a Protein Coding gene. Among its related pathways are Hedgehog Signaling Pathway. An important paralog of this gene is PTCHD2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISP2 Gene

Genomics for DISP2 Gene

Genomic Location for DISP2 Gene

Start:
40,358,233 bp from pter
End:
40,371,056 bp from pter
Size:
12,824 bases
Orientation:
Plus strand

Genomic View for DISP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISP2 Gene

Regulatory Elements for DISP2 Gene

Proteins for DISP2 Gene

  • Protein details for DISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7MBM2-DISP2_HUMAN
    Recommended name:
    Protein dispatched homolog 2
    Protein Accession:
    A7MBM2
    Secondary Accessions:
    • Q6AHW3
    • Q9C0C1

    Protein attributes for DISP2 Gene

    Size:
    1401 amino acids
    Molecular mass:
    152003 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21833.2; Type=Erroneous termination; Positions=100; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for DISP2 Gene

Proteomics data for DISP2 Gene at MOPED

Post-translational modifications for DISP2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn239, Asn349, and Asn465

Other Protein References for DISP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DISP2 Gene

Domains for DISP2 Gene

Protein Domains for DISP2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DISP2_HUMAN
Domain:
  • Contains 1 SSD (sterol-sensing) domain.:
    • A7MBM2
Family:
  • Belongs to the dispatched family.:
    • A7MBM2
genes like me logo Genes that share domains with DISP2: view

No data available for Gene Families for DISP2 Gene

Function for DISP2 Gene

Gene Ontology (GO) - Molecular Function for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DISP2: view

Phenotypes for DISP2 Gene

GenomeRNAi human phenotypes for DISP2:
genes like me logo Genes that share phenotypes with DISP2: view

miRNA for DISP2 Gene

miRTarBase miRNAs that target DISP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DISP2 Gene

Localization for DISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DISP2 Gene COMPARTMENTS Subcellular localization image for DISP2 gene
Compartment Confidence
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DISP2: view

Pathways for DISP2 Gene

SuperPathways for DISP2 Gene

Superpath Contained pathways
1 Hedgehog Signaling Pathway
genes like me logo Genes that share pathways with DISP2: view

Pathways by source for DISP2 Gene

1 Tocris pathway for DISP2 Gene

Interacting Proteins for DISP2 Gene

Gene Ontology (GO) - Biological Process for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway NAS 16258256
genes like me logo Genes that share ontologies with DISP2: view

Transcripts for DISP2 Gene

mRNA/cDNA for DISP2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DISP2 Gene

Dispatched homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DISP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: -
SP2:
SP3:

Relevant External Links for DISP2 Gene

GeneLoc Exon Structure for
DISP2
ECgene alternative splicing isoforms for
DISP2

Expression for DISP2 Gene

mRNA expression in normal human tissues for DISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DISP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (9.6) and Brain - Cerebellum (9.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DISP2 Gene

SOURCE GeneReport for Unigene cluster for DISP2 Gene Hs.355645

genes like me logo Genes that share expressions with DISP2: view

Orthologs for DISP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DISP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DISP2 36
  • 99.49 (n)
  • 99.41 (a)
DISP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DISP2 36
  • 88.74 (n)
  • 88.83 (a)
DISP2 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DISP2 36
  • 89.14 (n)
  • 89.14 (a)
DISP2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Disp2 36
  • 79.4 (n)
  • 76.4 (a)
Disp2 16
Disp2 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DISP2 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 15 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Disp2 36
  • 79.6 (n)
  • 77.29 (a)
chicken
(Gallus gallus)
Aves DISP2 36
  • 61.24 (n)
  • 57.91 (a)
DISP2 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DISP2 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia disp2 36
  • 58.42 (n)
  • 56.26 (a)
zebrafish
(Danio rerio)
Actinopterygii disp2 36
  • 53.93 (n)
  • 49.96 (a)
disp2 37
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta disp 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-14 37
  • 20 (a)
ManyToMany
ptd-2 37
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for DISP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DISP2 Gene

ENSEMBL:
Gene Tree for DISP2 (if available)
TreeFam:
Gene Tree for DISP2 (if available)

Paralogs for DISP2 Gene

Paralogs for DISP2 Gene

Selected SIMAP similar genes for DISP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DISP2: view

Variants for DISP2 Gene

Sequence variations from dbSNP and Humsavar for DISP2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13314 -- 40,370,807(+) TTCCC(C/T)CTCTT utr-variant-3-prime
rs1007177 -- 40,359,637(-) GGACA(C/T)GGCTG intron-variant
rs1898882 - 40,363,672(-) GGGAG(C/G)AGCTT missense, reference
rs1898883 - 40,363,644(-) AGGGG(C/G)CACAG reference, missense
rs1992272 -- 40,366,769(-) ACTCC(A/G)TGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DISP2 Gene

Variant ID Type Subtype PubMed ID
esv34145 CNV Loss 18971310
nsv510660 CNV Loss 20534489
nsv820173 CNV Gain 19587683

Relevant External Links for DISP2 Gene

HapMap Linkage Disequilibrium report
DISP2

Disorders for DISP2 Gene

No disorders were found for DISP2 Gene.

No data available for UniProtKB/Swiss-Prot for DISP2 Gene

Publications for DISP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. (PMID: 10619433) Burke R. … Basler K. (Cell 1999) 2 3
  3. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. (PMID: 12372301) Ma Y. … Beachy P.A. (Cell 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for DISP2 Gene

Sources for DISP2 Gene

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