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Aliases for DISP2 Gene

Aliases for DISP2 Gene

  • Dispatched RND Transporter Family Member 2 2 3 5
  • DISPB 3 4
  • Dispatched Homolog 2 (Drosophila) 2
  • Protein Dispatched Homolog 2 3
  • Dispatched Homolog 2 3
  • Dispatched B 3
  • LINC00594 3
  • HsT16908 3
  • KIAA1742 4

External Ids for DISP2 Gene

Previous GeneCards Identifiers for DISP2 Gene

  • GC15P038366
  • GC15P038437
  • GC15P040650
  • GC15P017493

Summaries for DISP2 Gene

Entrez Gene Summary for DISP2 Gene

  • The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched. [provided by RefSeq, Jul 2008]

GeneCards Summary for DISP2 Gene

DISP2 (Dispatched RND Transporter Family Member 2) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Signaling by GPCR. An important paralog of this gene is DISP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISP2 Gene

Genomics for DISP2 Gene

Regulatory Elements for DISP2 Gene

Enhancers for DISP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F040435 1.3 Ensembl ENCODE 34.9 +84.7 84658 7.8 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 GLIS2 FOS SP3 SP5 KNSTRN DISP2 IVD C15orf57 CHST14 RPL9P27 PHGR1 C15orf52 RNA5SP392 RPLP0P10
GH15F040366 1.3 Ensembl ENCODE 33 +13.3 13342 2.6 ATF1 CREB3L1 ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 ELK1 ZNF143 KNSTRN DISP2 IVD RAD51-AS1 ENSG00000259211 EIF2AK4 ENSG00000259368
GH15F040326 1.3 Ensembl ENCODE 32.2 -13.3 -13296 28.7 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 ZNF207 FOS KNSTRN DISP2 IVD ENSG00000259211 DNAJC17 BAHD1 ANKRD63 RPLP0P10 PLCB2 BMF
GH15F040430 1.1 Ensembl ENCODE 33.8 +76.1 76063 0.8 CBX3 PKNOX1 ZIC2 ZNF316 GATA3 ZNF366 GATA2 PATZ1 PRDM10 NFE2 KNSTRN DISP2 IVD BAHD1 PIR57787 GC15P040422
GH15F040379 1 Ensembl ENCODE 34.8 +25.7 25706 1.9 TAL1 JUN MAX RFX5 YY1 ZFHX2 RCOR1 FOS NFE2 NFE2L2 KNSTRN DISP2 ENSG00000259368
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DISP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DISP2 Gene

40,354,359 bp from pter
40,378,639 bp from pter
24,281 bases
Plus strand

Genomic View for DISP2 Gene

Genes around DISP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DISP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISP2 Gene

Proteins for DISP2 Gene

  • Protein details for DISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein dispatched homolog 2
    Protein Accession:
    Secondary Accessions:
    • Q6AHW3
    • Q9C0C1

    Protein attributes for DISP2 Gene

    1401 amino acids
    Molecular mass:
    152003 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB21833.2; Type=Erroneous termination; Positions=100; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for DISP2 Gene

Post-translational modifications for DISP2 Gene

  • Glycosylation at Asn 239, Asn 349, and Asn 465
  • Modification sites at PhosphoSitePlus

Other Protein References for DISP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DISP2

No data available for DME Specific Peptides for DISP2 Gene

Domains & Families for DISP2 Gene

Protein Domains for DISP2 Gene


Suggested Antigen Peptide Sequences for DISP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SSD (sterol-sensing) domain.
  • Belongs to the dispatched family.
  • Contains 1 SSD (sterol-sensing) domain.
  • Belongs to the dispatched family.
genes like me logo Genes that share domains with DISP2: view

No data available for Gene Families for DISP2 Gene

Function for DISP2 Gene

Gene Ontology (GO) - Molecular Function for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DISP2: view
genes like me logo Genes that share phenotypes with DISP2: view

Animal Model Products

miRNA for DISP2 Gene

miRTarBase miRNAs that target DISP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DISP2 Gene

Localization for DISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISP2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DISP2 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DISP2: view

Pathways & Interactions for DISP2 Gene

genes like me logo Genes that share pathways with DISP2: view

Pathways by source for DISP2 Gene

Interacting Proteins for DISP2 Gene

Gene Ontology (GO) - Biological Process for DISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway NAS 16258256
genes like me logo Genes that share ontologies with DISP2: view

No data available for SIGNOR curated interactions for DISP2 Gene

Transcripts for DISP2 Gene

mRNA/cDNA for DISP2 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DISP2 Gene

Dispatched homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DISP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: -

Relevant External Links for DISP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DISP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DISP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.6) and Brain - Cerebellum (x9.6).

Protein differential expression in normal tissues from HIPED for DISP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (43.9) and Frontal cortex (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DISP2 Gene

Protein tissue co-expression partners for DISP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DISP2 Gene:


SOURCE GeneReport for Unigene cluster for DISP2 Gene:

genes like me logo Genes that share expression patterns with DISP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DISP2 Gene

Orthologs for DISP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DISP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DISP2 34 35
  • 99.49 (n)
(Canis familiaris)
Mammalia DISP2 34 35
  • 89.14 (n)
(Bos Taurus)
Mammalia DISP2 34 35
  • 88.74 (n)
(Rattus norvegicus)
Mammalia Disp2 34
  • 79.6 (n)
(Mus musculus)
Mammalia Disp2 34 16 35
  • 79.4 (n)
(Monodelphis domestica)
Mammalia DISP2 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 15 (a)
(Gallus gallus)
Aves DISP2 34 35
  • 61.24 (n)
(Anolis carolinensis)
Reptilia DISP2 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia disp2 34
  • 58.42 (n)
(Danio rerio)
Actinopterygii disp2 34 35
  • 53.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta disp 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea che-14 35
  • 20 (a)
ptd-2 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for DISP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DISP2 Gene

Gene Tree for DISP2 (if available)
Gene Tree for DISP2 (if available)

Paralogs for DISP2 Gene

Paralogs for DISP2 Gene

(1) SIMAP similar genes for DISP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DISP2: view

Variants for DISP2 Gene

Sequence variations from dbSNP and Humsavar for DISP2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1007177 -- 40,359,637(-) GGACA(C/T)GGCTG intron-variant
rs11070266 -- 40,352,575(+) CACCC(A/C)CTTCC intron-variant, upstream-variant-2KB
rs11070267 -- 40,361,618(+) CATGA(A/G)GGTCA intron-variant
rs11070268 -- 40,373,229(+) GAGGC(A/G)TACAA intron-variant
rs111238108 -- 40,369,047(+) CCACA(C/T)TGCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DISP2 Gene

Variant ID Type Subtype PubMed ID
esv34145 CNV loss 18971310
nsv1160287 CNV duplication 26073780
nsv472977 CNV novel sequence insertion 20440878
nsv510660 CNV deletion 20534489
nsv820173 CNV gain 19587683

Variation tolerance for DISP2 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DISP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DISP2 Gene

Disorders for DISP2 Gene

Relevant External Links for DISP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DISP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DISP2 Gene

Publications for DISP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. (PMID: 10619433) Burke R. … Basler K. (Cell 1999) 2 3 64
  3. Pancreatic islet and progenitor cell surface markers with cell sorting potential. (PMID: 21947380) Hald J. … Madsen O.D. (Diabetologia 2012) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for DISP2 Gene

Sources for DISP2 Gene

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