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Aliases for DISP1 Gene

Aliases for DISP1 Gene

  • Dispatched RND Transporter Family Member 1 2 3 5
  • DISPA 3 4
  • Dispatched Homolog 1 (Drosophila) 2
  • Protein Dispatched Homolog 1 3
  • Dispatched A 3

External Ids for DISP1 Gene

Previous GeneCards Identifiers for DISP1 Gene

  • GC01P220158
  • GC01P219490
  • GC01P221112
  • GC01P222989
  • GC01P193775
  • GC01P222820

Summaries for DISP1 Gene

Entrez Gene Summary for DISP1 Gene

  • The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]

GeneCards Summary for DISP1 Gene

DISP1 (Dispatched RND Transporter Family Member 1) is a Protein Coding gene. Diseases associated with DISP1 include Microform Holoprosencephaly and Septopreoptic Holoprosencephaly. Among its related pathways are Hedgehog Pathway. Gene Ontology (GO) annotations related to this gene include hedgehog receptor activity and peptide transporter activity. An important paralog of this gene is DISP2.

UniProtKB/Swiss-Prot for DISP1 Gene

  • Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404).

Additional gene information for DISP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISP1 Gene

Genomics for DISP1 Gene

GeneHancer (GH) Regulatory Elements for DISP1 Gene

Promoters and enhancers for DISP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I222813 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 552.8 +0.3 261 2.5 ARID4B SIN3A GLI4 ZNF2 IRF4 ZNF48 YY1 FOS RUNX3 KLF13 LOC102724017 DISP1 ENSG00000278610 CICP13 ENSG00000272750 HHIPL2
GH01I222928 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 575.1 +113.8 113826 0.7 LEF1 PKNOX1 TAF1 BACH1 MAX SIN3A RAD21 YY1 HIC1 ZNF335 DISP1 LOC102724017 CICP13 CAPN2 TAF1A GC01M222927 ENSG00000278610
GH01I222710 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 -102.0 -102022 3.9 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 BROX AIDA CICP13 ENSG00000272750 TAF1A CAPN2 DISP1 MIA3 FAM177B GC01M222708
GH01I223018 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.4 +206.8 206814 6.4 PKNOX1 KLF17 FEZF1 ZNF335 GLIS2 SCRT2 KLF7 ZNF398 TSHZ1 ZEB2 DISP1 ENSG00000272750 LOC102724017 TLR5 CAPN2 NDUFB1P2 LOC102724046
GH01I223704 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +892.5 892539 5.5 HDGF PKNOX1 FOXA2 ARNT NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105373281 CICP5 CAPN2 WDR26 LOC100287497 NVL CNIH4 CAPN8 FBXO28 AIDA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DISP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DISP1 gene promoter:

Genomic Locations for DISP1 Gene

Genomic Locations for DISP1 Gene
191,482 bases
Plus strand

Genomic View for DISP1 Gene

Genes around DISP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DISP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DISP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISP1 Gene

Proteins for DISP1 Gene

  • Protein details for DISP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein dispatched homolog 1
    Protein Accession:
    Secondary Accessions:
    • Q8N7C2
    • Q96I92
    • Q9H698
    • Q9H8H9
    • Q9UFA2

    Protein attributes for DISP1 Gene

    1524 amino acids
    Molecular mass:
    170934 Da
    Quaternary structure:
    • Interacts with SHH via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (PubMed:22902404).
    • Sequence=AAH07734.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14637.1; Type=Frameshift; Positions=1391, 1393, 1413; Evidence={ECO:0000305}; Sequence=BAB15365.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DISP1 Gene

Post-translational modifications for DISP1 Gene

  • Glycosylation at Asn59 and Asn582

No data available for DME Specific Peptides for DISP1 Gene

Domains & Families for DISP1 Gene

Gene Families for DISP1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DISP1 Gene


Suggested Antigen Peptide Sequences for DISP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dispatched family.
  • Belongs to the dispatched family.
genes like me logo Genes that share domains with DISP1: view

Function for DISP1 Gene

Molecular function for DISP1 Gene

UniProtKB/Swiss-Prot Function:
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404).

Phenotypes From GWAS Catalog for DISP1 Gene

Gene Ontology (GO) - Molecular Function for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015197 peptide transporter activity ISS,IEA --
genes like me logo Genes that share ontologies with DISP1: view
genes like me logo Genes that share phenotypes with DISP1: view

Animal Models for DISP1 Gene

MGI Knock Outs for DISP1:

Animal Model Products

miRNA for DISP1 Gene

miRTarBase miRNAs that target DISP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DISP1 Gene

Localization for DISP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISP1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DISP1 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane ISS --
genes like me logo Genes that share ontologies with DISP1: view

Pathways & Interactions for DISP1 Gene

SuperPathways for DISP1 Gene

SuperPathway Contained pathways
1 Hedgehog Pathway
genes like me logo Genes that share pathways with DISP1: view

Pathways by source for DISP1 Gene

1 Tocris pathway for DISP1 Gene

SIGNOR curated interactions for DISP1 Gene


Gene Ontology (GO) - Biological Process for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway IEA,NAS 16258256
GO:0007225 patched ligand maturation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with DISP1: view

Drugs & Compounds for DISP1 Gene

No Compound Related Data Available

Transcripts for DISP1 Gene

Unigene Clusters for DISP1 Gene

Dispatched homolog 1 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DISP1 Gene

No ASD Table

Relevant External Links for DISP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DISP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DISP1 Gene

Protein differential expression in normal tissues from HIPED for DISP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DISP1 Gene

Protein tissue co-expression partners for DISP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DISP1 Gene:


SOURCE GeneReport for Unigene cluster for DISP1 Gene:


Evidence on tissue expression from TISSUES for DISP1 Gene

  • Kidney(4.2)
  • Intestine(4.1)
  • Muscle(4.1)
  • Nervous system(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DISP1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Head and neck:
  • brain
  • eye
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
  • skin
genes like me logo Genes that share expression patterns with DISP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DISP1 Gene

Orthologs for DISP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DISP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DISP1 33 34
  • 99.39 (n)
(Bos Taurus)
Mammalia DISP1 34
  • 89 (a)
(Monodelphis domestica)
Mammalia DISP1 34
  • 86 (a)
(Mus musculus)
Mammalia Disp1 33 16 34
  • 82.37 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
-- 34
  • 78 (a)
(Rattus norvegicus)
Mammalia Disp1 33
  • 81.72 (n)
(Canis familiaris)
Mammalia DISP1 33 34
  • 74.8 (n)
(Gallus gallus)
Aves DISP1 33 34
  • 77.41 (n)
(Anolis carolinensis)
Reptilia DISP1 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia disp1 33
  • 75.99 (n)
(Danio rerio)
Actinopterygii disp1 33 34
  • 68.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004140 33
  • 51.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta disp 33 34
  • 48.66 (n)
(Caenorhabditis elegans)
Secernentea ptd-2 33 34
  • 41.94 (n)
che-14 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for DISP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DISP1 Gene

Gene Tree for DISP1 (if available)
Gene Tree for DISP1 (if available)

Paralogs for DISP1 Gene

Paralogs for DISP1 Gene

(1) SIMAP similar genes for DISP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DISP1: view

Variants for DISP1 Gene

Sequence variations from dbSNP and Humsavar for DISP1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1029577112 uncertain-significance, Holoprosencephaly sequence 222,991,599(+) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs749035153 likely-pathogenic, microform holoprosencephaly 223,004,295(+) G/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, stop_gained
rs760562145 uncertain-significance, Lobar holoprosencephaly 223,003,054(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs876661336 uncertain-significance, Lobar holoprosencephaly 223,002,484(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1064793099 uncertain-significance, not specified 223,005,403(+) CCC/CC coding_sequence_variant, frameshift, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DISP1 Gene

Variant ID Type Subtype PubMed ID
esv1553806 CNV insertion 17803354
esv2723328 CNV deletion 23290073
esv3547277 CNV deletion 23714750
esv3578452 CNV loss 25503493
esv3578453 CNV loss 25503493
esv3588951 CNV loss 21293372
esv5267 CNV loss 18987735
esv991453 CNV insertion 20482838
esv998735 CNV deletion 20482838
nsv1160101 CNV deletion 26073780
nsv442589 CNV loss 18776908

Variation tolerance for DISP1 Gene

Residual Variation Intolerance Score: 6.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.48; 95.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DISP1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DISP1 Gene

Disorders for DISP1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for DISP1 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DISP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DISP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DISP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DISP1 Gene

Publications for DISP1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. (PMID: 10619433) Burke R … Basler K (Cell 1999) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Whole-genome association analysis of treatment response in obsessive-compulsive disorder. (PMID: 25824302) Qin H … Shugart YY (Molecular psychiatry 2016) 3 58

Products for DISP1 Gene

Sources for DISP1 Gene

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