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Aliases for DISP1 Gene

Aliases for DISP1 Gene

  • Dispatched Homolog 1 (Drosophila) 2 3
  • DISPA 3 4 6
  • Protein Dispatched Homolog 1 3
  • Dispatched A 3

External Ids for DISP1 Gene

Previous GeneCards Identifiers for DISP1 Gene

  • GC01P220158
  • GC01P219490
  • GC01P221112
  • GC01P222989
  • GC01P193775

Summaries for DISP1 Gene

Entrez Gene Summary for DISP1 Gene

  • The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]

GeneCards Summary for DISP1 Gene

DISP1 (Dispatched Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with DISP1 include septopreoptic holoprosencephaly and midline interhemispheric variant of holoprosencephaly. Among its related pathways are Hedgehog Signaling Pathway. GO annotations related to this gene include hedgehog receptor activity and peptide transporter activity. An important paralog of this gene is DISP2.

UniProtKB/Swiss-Prot for DISP1 Gene

  • Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISP1 Gene

Genomics for DISP1 Gene

Regulatory Elements for DISP1 Gene

Genomic Location for DISP1 Gene

Start:
222,815,089 bp from pter
End:
223,005,995 bp from pter
Size:
190,907 bases
Orientation:
Plus strand

Genomic View for DISP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DISP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISP1 Gene

Proteins for DISP1 Gene

  • Protein details for DISP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F81-DISP1_HUMAN
    Recommended name:
    Protein dispatched homolog 1
    Protein Accession:
    Q96F81
    Secondary Accessions:
    • Q8N7C2
    • Q96I92
    • Q9H698
    • Q9H8H9
    • Q9UFA2

    Protein attributes for DISP1 Gene

    Size:
    1524 amino acids
    Molecular mass:
    170934 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH07734.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14637.1; Type=Frameshift; Positions=1391, 1393, 1413; Evidence={ECO:0000305}; Sequence=BAB15365.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DISP1 Gene

Proteomics data for DISP1 Gene at MOPED

Post-translational modifications for DISP1 Gene

  • Glycosylation at Asn59 and Asn582
  • Modification sites at PhosphoSitePlus

Other Protein References for DISP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DISP1 Gene

Domains for DISP1 Gene

Protein Domains for DISP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DISP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F81

UniProtKB/Swiss-Prot:

DISP1_HUMAN :
  • Q96F81
Domain:
  • Contains 1 SSD (sterol-sensing) domain.
Family:
  • Belongs to the dispatched family.
genes like me logo Genes that share domains with DISP1: view

No data available for Gene Families for DISP1 Gene

Function for DISP1 Gene

Molecular function for DISP1 Gene

UniProtKB/Swiss-Prot Function: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).

Gene Ontology (GO) - Molecular Function for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008158 hedgehog receptor activity IEA --
GO:0015197 peptide transporter activity ISS --
genes like me logo Genes that share ontologies with DISP1: view
genes like me logo Genes that share phenotypes with DISP1: view

Animal Models for DISP1 Gene

MGI Knock Outs for DISP1:

Animal Model Products

CRISPR Products

miRNA for DISP1 Gene

miRTarBase miRNAs that target DISP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DISP1 Gene

Localization for DISP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISP1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DISP1 Gene COMPARTMENTS Subcellular localization image for DISP1 gene
Compartment Confidence
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DISP1: view

Pathways for DISP1 Gene

SuperPathways for DISP1 Gene

Superpath Contained pathways
1 Hedgehog Signaling Pathway
genes like me logo Genes that share pathways with DISP1: view

Pathways by source for DISP1 Gene

1 Tocris pathway for DISP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for DISP1 Gene

Gene Ontology (GO) - Biological Process for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway NAS 16258256
GO:0007225 patched ligand maturation IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0007389 pattern specification process --
GO:0009880 embryonic pattern specification IEA --
genes like me logo Genes that share ontologies with DISP1: view

Transcripts for DISP1 Gene

Unigene Clusters for DISP1 Gene

Dispatched homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DISP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DISP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DISP1 Gene

No ASD Table

Relevant External Links for DISP1 Gene

GeneLoc Exon Structure for
DISP1
ECgene alternative splicing isoforms for
DISP1

Expression for DISP1 Gene

mRNA expression in normal human tissues for DISP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DISP1 Gene

SOURCE GeneReport for Unigene cluster for DISP1 Gene Hs.528817

genes like me logo Genes that share expressions with DISP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DISP1 Gene

Orthologs for DISP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DISP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DISP1 35
  • 99.39 (n)
  • 99.15 (a)
DISP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DISP1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DISP1 35
  • 74.8 (n)
  • 76.47 (a)
DISP1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Disp1 35
  • 82.37 (n)
  • 85.14 (a)
Disp1 16
Disp1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DISP1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Disp1 35
  • 81.72 (n)
  • 83.53 (a)
chicken
(Gallus gallus)
Aves DISP1 35
  • 77.41 (n)
  • 80.53 (a)
DISP1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DISP1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia disp1 35
  • 75.99 (n)
  • 83.89 (a)
zebrafish
(Danio rerio)
Actinopterygii disp1 35
  • 68.61 (n)
  • 74.26 (a)
disp1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004140 35
  • 51.25 (n)
  • 42.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta disp 35
  • 48.66 (n)
  • 37.59 (a)
disp 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-14 36
  • 21 (a)
ManyToMany
ptd-2 35
  • 41.94 (n)
  • 27.05 (a)
ptd-2 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for DISP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DISP1 Gene

ENSEMBL:
Gene Tree for DISP1 (if available)
TreeFam:
Gene Tree for DISP1 (if available)

Paralogs for DISP1 Gene

Paralogs for DISP1 Gene

Selected SIMAP similar genes for DISP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DISP1: view

Variants for DISP1 Gene

Sequence variations from dbSNP and Humsavar for DISP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs728006 -- 222,967,926(+) TCCTC(C/T)GGTCT intron-variant
rs946505 -- 222,979,352(-) CACTG(C/T)AGTCT intron-variant, upstream-variant-2KB
rs946506 -- 222,979,285(-) CAGGC(A/G)TGCGC intron-variant, upstream-variant-2KB
rs946507 -- 222,975,968(-) GCTGT(A/G)GTGTA intron-variant
rs946508 -- 222,971,479(-) CTACA(A/G)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DISP1 Gene

Variant ID Type Subtype PubMed ID
nsv873206 CNV Loss 21882294
nsv442589 CNV CNV 18776908
esv5267 CNV Deletion 18987735
esv998735 CNV Deletion 20482838
esv2723328 CNV Deletion 23290073
nsv873207 CNV Loss 21882294
esv991453 CNV Insertion 20482838
esv1553806 CNV Insertion 17803354

Relevant External Links for DISP1 Gene

HapMap Linkage Disequilibrium report
DISP1
Human Gene Mutation Database (HGMD)
DISP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DISP1 Gene

Disorders for DISP1 Gene

(2) University of Copenhagen DISEASES for DISP1 Gene

Relevant External Links for DISP1

Genetic Association Database (GAD)
DISP1
Human Genome Epidemiology (HuGE) Navigator
DISP1
genes like me logo Genes that share disorders with DISP1: view

No data available for UniProtKB/Swiss-Prot for DISP1 Gene

Publications for DISP1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. (PMID: 10619433) Burke R. … Basler K. (Cell 1999) 2 3
  4. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. (PMID: 12372301) Ma Y. … Beachy P.A. (Cell 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DISP1 Gene

Sources for DISP1 Gene

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