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Aliases for DISP1 Gene

Aliases for DISP1 Gene

  • Dispatched RND Transporter Family Member 1 2 3 5
  • DISPA 3 4
  • Dispatched Homolog 1 (Drosophila) 2
  • Protein Dispatched Homolog 1 3
  • Dispatched A 3

External Ids for DISP1 Gene

Previous GeneCards Identifiers for DISP1 Gene

  • GC01P220158
  • GC01P219490
  • GC01P221112
  • GC01P222989
  • GC01P193775
  • GC01P222820

Summaries for DISP1 Gene

Entrez Gene Summary for DISP1 Gene

  • The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]

GeneCards Summary for DISP1 Gene

DISP1 (Dispatched RND Transporter Family Member 1) is a Protein Coding gene. Diseases associated with DISP1 include Alobar Holoprosencephaly and Single Median Maxillary Central Incisor. Among its related pathways are Hedgehog Pathway. GO annotations related to this gene include hedgehog receptor activity and peptide transporter activity. An important paralog of this gene is DISP2.

UniProtKB/Swiss-Prot for DISP1 Gene

  • Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISP1 Gene

Genomics for DISP1 Gene

Regulatory Elements for DISP1 Gene

Enhancers for DISP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G223018 1.4 Ensembl ENCODE dbSUPER 17.4 +206.8 206815 6.4 PKNOX1 KLF17 FEZF1 GLIS2 SCRT2 KLF7 MCM3 TSHZ1 ZNF488 ZEB2 DISP1 ENSG00000272750 LOC102724017 TLR5 CAPN2 NDUFB1P2 LOC102724046
GH01G222928 1.1 Ensembl ENCODE 16.8 +113.8 113827 0.7 CTCF LEF1 PKNOX1 CBX3 TAF1 MAX RBBP5 CHD7 RAD21 YY1 DISP1 LOC102724017 GC01M222927 ENSG00000278610
GH01G222915 0.9 Ensembl ENCODE 17.3 +100.8 100841 0.3 CTCF MAFG CEBPB OVOL3 ZNF704 ZNF791 ZNF747 ZNF169 TCF7 NFE2 CICP13 ENSG00000272750 DISP1 LOC102724017 GC01M222927 ENSG00000278610
GH01G222891 0.9 Ensembl ENCODE 15.7 +77.7 77721 1.4 JUN NR2F1 NR2F2 YY1 JUND SCRT2 HNF4A NR2F6 FOS HOMEZ LOC102724017 DISP1 GC01M222927 ENSG00000278610
GH01G222974 1.1 FANTOM5 ENCODE 12.7 +160.2 160158 0.2 SIN3A FEZF1 GATA2 ZNF366 ZSCAN5C SCRT2 FOS ZNF391 ZNF362 OVOL3 DISP1 LOC102724017 ENSG00000272750 NDUFB1P2 LOC102724046
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DISP1 on UCSC Golden Path with GeneCards custom track

Promoters for DISP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000020673 786 1401 ARID4B SIN3A GLI4 ZNF2 ZNF48 YY1 ELK1 FOS SP3 ZHX2

Genomic Location for DISP1 Gene

Chromosome:
1
Start:
222,814,514 bp from pter
End:
223,005,995 bp from pter
Size:
191,482 bases
Orientation:
Plus strand

Genomic View for DISP1 Gene

Genes around DISP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DISP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DISP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISP1 Gene

Proteins for DISP1 Gene

  • Protein details for DISP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F81-DISP1_HUMAN
    Recommended name:
    Protein dispatched homolog 1
    Protein Accession:
    Q96F81
    Secondary Accessions:
    • Q8N7C2
    • Q96I92
    • Q9H698
    • Q9H8H9
    • Q9UFA2

    Protein attributes for DISP1 Gene

    Size:
    1524 amino acids
    Molecular mass:
    170934 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH07734.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14637.1; Type=Frameshift; Positions=1391, 1393, 1413; Evidence={ECO:0000305}; Sequence=BAB15365.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DISP1 Gene

Post-translational modifications for DISP1 Gene

  • Glycosylation at isoforms=59 and Asn582
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DISP1 Gene

Domains & Families for DISP1 Gene

Protein Domains for DISP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DISP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F81

UniProtKB/Swiss-Prot:

DISP1_HUMAN :
  • Belongs to the dispatched family.
Family:
  • Belongs to the dispatched family.
genes like me logo Genes that share domains with DISP1: view

No data available for Gene Families for DISP1 Gene

Function for DISP1 Gene

Molecular function for DISP1 Gene

UniProtKB/Swiss-Prot Function:
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).

Gene Ontology (GO) - Molecular Function for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015197 peptide transporter activity ISS,IEA --
genes like me logo Genes that share ontologies with DISP1: view
genes like me logo Genes that share phenotypes with DISP1: view

Animal Models for DISP1 Gene

MGI Knock Outs for DISP1:

Animal Model Products

CRISPR Products

miRNA for DISP1 Gene

miRTarBase miRNAs that target DISP1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DISP1 Gene

Localization for DISP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DISP1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DISP1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane ISS --
genes like me logo Genes that share ontologies with DISP1: view

Pathways & Interactions for DISP1 Gene

SuperPathways for DISP1 Gene

SuperPathway Contained pathways
1 Hedgehog Pathway
genes like me logo Genes that share pathways with DISP1: view

Pathways by source for DISP1 Gene

1 Tocris pathway for DISP1 Gene

SIGNOR curated interactions for DISP1 Gene

Activates:

Gene Ontology (GO) - Biological Process for DISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway NAS,IEA 16258256
GO:0007225 patched ligand maturation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with DISP1: view

Drugs & Compounds for DISP1 Gene

No Compound Related Data Available

Transcripts for DISP1 Gene

Unigene Clusters for DISP1 Gene

Dispatched homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DISP1 Gene

No ASD Table

Relevant External Links for DISP1 Gene

GeneLoc Exon Structure for
DISP1
ECgene alternative splicing isoforms for
DISP1

Expression for DISP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DISP1 Gene

Protein differential expression in normal tissues from HIPED for DISP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DISP1 Gene



Protein tissue co-expression partners for DISP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DISP1 Gene:

DISP1

SOURCE GeneReport for Unigene cluster for DISP1 Gene:

Hs.528817

Evidence on tissue expression from TISSUES for DISP1 Gene

  • Kidney(4.2)
  • Intestine(4.1)
  • Muscle(4.1)
  • Nervous system(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DISP1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Organs:
Head and neck:
  • brain
  • eye
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
General:
  • skin
genes like me logo Genes that share expression patterns with DISP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DISP1 Gene

Orthologs for DISP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DISP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DISP1 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia DISP1 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DISP1 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Disp1 34 16 35
  • 82.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Disp1 34
  • 81.72 (n)
dog
(Canis familiaris)
Mammalia DISP1 34 35
  • 74.8 (n)
chicken
(Gallus gallus)
Aves DISP1 34 35
  • 77.41 (n)
lizard
(Anolis carolinensis)
Reptilia DISP1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia disp1 34
  • 75.99 (n)
zebrafish
(Danio rerio)
Actinopterygii disp1 34 35
  • 68.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004140 34
  • 51.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta disp 34 35
  • 48.66 (n)
worm
(Caenorhabditis elegans)
Secernentea ptd-2 34 35
  • 41.94 (n)
che-14 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for DISP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DISP1 Gene

ENSEMBL:
Gene Tree for DISP1 (if available)
TreeFam:
Gene Tree for DISP1 (if available)

Paralogs for DISP1 Gene

Paralogs for DISP1 Gene

(1) SIMAP similar genes for DISP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DISP1: view

Variants for DISP1 Gene

Sequence variations from dbSNP and Humsavar for DISP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs749035153 Likely pathogenic 223,004,295(+) GGTTG(A/G/T)TTTGT reference, missense
rs750541511 Uncertain significance 223,005,389(+) CACGC(A/C)CATCC reference, missense
rs760562145 Uncertain significance 223,003,054(+) ACTTC(A/G)AATTT reference, missense
rs864309626 Uncertain significance 223,005,590(+) CAGAA(A/G)CACTG reference, missense
rs876661336 Uncertain significance 223,002,484(+) TGAAC(A/G)ATAGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DISP1 Gene

Variant ID Type Subtype PubMed ID
esv1553806 CNV insertion 17803354
esv2723328 CNV deletion 23290073
esv3547277 CNV deletion 23714750
esv3578452 CNV loss 25503493
esv3578453 CNV loss 25503493
esv3588951 CNV loss 21293372
esv5267 CNV loss 18987735
esv991453 CNV insertion 20482838
esv998735 CNV deletion 20482838
nsv1160101 CNV deletion 26073780
nsv442589 CNV loss 18776908

Variation tolerance for DISP1 Gene

Residual Variation Intolerance Score: 6.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.48; 95.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DISP1 Gene

Human Gene Mutation Database (HGMD)
DISP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DISP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DISP1 Gene

Disorders for DISP1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for DISP1 Gene - From: Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search DISP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DISP1

Genetic Association Database (GAD)
DISP1
Human Genome Epidemiology (HuGE) Navigator
DISP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DISP1
genes like me logo Genes that share disorders with DISP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DISP1 Gene

Publications for DISP1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. (PMID: 10619433) Burke R. … Basler K. (Cell 1999) 2 3 64
  4. Whole-genome association analysis of treatment response in obsessive-compulsive disorder. (PMID: 25824302) Qin H. … Shugart Y.Y. (Mol. Psychiatry 2015) 3 64
  5. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. (PMID: 26631746) Zhang C. … Kaelin W.G. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 64

Products for DISP1 Gene

Sources for DISP1 Gene

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