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Aliases for DISC2 Gene

Subcategory (RNA class) for DISC2 Gene

non-coding RNA

Quality Score for this RNA gene is

2

Aliases for DISC2 Gene

  • Disrupted In Schizophrenia 2 (Non-Protein Coding) 2 3
  • DISC1 Antisense RNA 1 2 3
  • Non-Protein Coding RNA 15 2
  • DISC1 Opposite Strand 3
  • NCRNA00015 3
  • DISC1-AS1 3
  • DISC1OS 3

External Ids for DISC2 Gene

Previous GeneCards Identifiers for DISC2 Gene

  • GC01U990288
  • GC01M230016
  • GC01M231950

Summaries for DISC2 Gene

Entrez Gene Summary for DISC2 Gene

  • DISC2 is thought to specify a noncoding RNA molecule antisense to DISC1 (MIM 605210). Both genes were found to be disrupted by a translocation in a large schizophrenia (MIM 181500) kindred.[supplied by OMIM, Jul 2002]

GeneCards Summary for DISC2 Gene

DISC2 (Disrupted In Schizophrenia 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with DISC2 include Schizophrenia.

Gene Wiki entry for DISC2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DISC2 Gene

Genomics for DISC2 Gene

Regulatory Elements for DISC2 Gene

Enhancers for DISC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G231826 1.1 Ensembl ENCODE 0.4 -9.7 -9653 2.8 FOXA2 NFIB SIN3A RFX5 GATA2 SCRT2 FOS EGR2 CEBPB PPARG DISC1 DISC2 LOC105373170
GH01G231837 0.7 ENCODE 0.4 -18.2 -18223 0.2 ELF3 SAP130 MLX ARID4B DMAP1 ZNF644 TEAD3 NCOR1 GATAD2A SOX5 LOC105373170 DISC2
GH01G231836 0.7 ENCODE 0.4 -17.8 -17774 0.4 NFIA MTA2 NFYC DMAP1 KAT8 NFIC PRDM6 NCOR1 ZSCAN5C SP7 DISC1 LOC105373170 DISC2
GH01G231844 0.8 Ensembl ENCODE 0.3 -26.7 -26655 0.9 CTCF GATA3 GATA2 FOS PRDM2 ZNF785 LOC105373170 DISC2
GH01G231842 0.8 ENCODE 0.3 -23.6 -23573 0.2 ELF3 THRB ZNF48 RARA FOS CREM THAP11 SP5 PPARG KAT8 LOC105373170 DISC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DISC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DISC2 Gene

Chromosome:
1
Start:
231,814,626 bp from pter
End:
231,818,517 bp from pter
Size:
3,892 bases
Orientation:
Minus strand

Genomic View for DISC2 Gene

Genes around DISC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DISC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DISC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DISC2 Gene

Proteins for DISC2 Gene

Post-translational modifications for DISC2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DISC2 Gene

Domains & Families for DISC2 Gene

Gene Families for DISC2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DISC2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DISC2 Gene

Function for DISC2 Gene

Human Phenotype Ontology for DISC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DISC2 Gene

Localization for DISC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DISC2 Gene

Pathways & Interactions for DISC2 Gene

SuperPathways for DISC2 Gene

No Data Available

Interacting Proteins for DISC2 Gene

Gene Ontology (GO) - Biological Process for DISC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DISC2 Gene

Transcripts for DISC2 Gene

mRNA/cDNA for DISC2 Gene

(1) Additional mRNA sequences :

Unigene Clusters for DISC2 Gene

Disrupted in schizophrenia 2 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DISC2 Gene

No ASD Table

Relevant External Links for DISC2 Gene

GeneLoc Exon Structure for
DISC2
ECgene alternative splicing isoforms for
DISC2

Expression for DISC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DISC2 Gene:

DISC2

SOURCE GeneReport for Unigene cluster for DISC2 Gene:

Hs.720568

Phenotype-based relationships between genes and organs from Gene ORGANizer for DISC2 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • head
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for DISC2 Gene

Orthologs for DISC2 Gene

No data available for Orthologs and Evolution for DISC2 Gene

Paralogs for DISC2 Gene

No data available for Paralogs for DISC2 Gene

Variants for DISC2 Gene

Sequence variations from dbSNP and Humsavar for DISC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6675281 untested 231,818,355(+) AAGAC(C/T)TCACC intron-variant, nc-transcript-variant, reference, synonymous-codon, missense, utr-variant-3-prime
rs1000253923 -- 231,814,957(+) TAATA(A/G)TAATA intron-variant, nc-transcript-variant
rs1000874564 -- 231,820,005(+) TCACA(A/G)TGATG intron-variant, upstream-variant-2KB
rs1002207014 -- 231,814,192(+) AGGAA(G/T)TGTTC intron-variant, nc-transcript-variant, downstream-variant-500B
rs1002540690 -- 231,815,923(+) ACTGT(A/G)ACCAT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DISC2 Gene

Variant ID Type Subtype PubMed ID
esv2762173 CNV loss 21179565

Relevant External Links for DISC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DISC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DISC2 Gene

Disorders for DISC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DISC2 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search DISC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DISC2

Genetic Association Database (GAD)
DISC2
Human Genome Epidemiology (HuGE) Navigator
DISC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DISC2
genes like me logo Genes that share disorders with DISC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DISC2 Gene

Publications for DISC2 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 46 64
  2. DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. (PMID: 15478311) Millar J.K. … Thomson P.A. (Ann. Med. 2004) 2 3 64
  3. Disruption of two novel genes by a schizophrenia-linked translocation. (PMID: 10814723) Millar J.K. … Porteous D.J. (Hum. Mol. Genet. 2000) 2 3 64
  4. lncRNAdb: a reference database for long noncoding RNAs. (PMID: 21112873) Amaral P.P. … Mattick J.S. (Nucleic Acids Res. 2011) 3 64
  5. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. (PMID: 20694011) Ferreira R.C. … HammarstrAPm L. (Nat. Genet. 2010) 46 64

Products for DISC2 Gene

Sources for DISC2 Gene

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