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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DISC2 Gene

RNA gene   GIFtS: 21
GCID: GC01M231950

disrupted in schizophrenia 2 (non-protein coding)
 Explore 1 disease affiliated with
DISC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DISC2    

Aliases
for DISC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 4

Aliases
Disrupted In Schizophrenia 2 (Non-Protein Coding)1 2
DISC1-AS11 2
DISC1OS1 2
NCRNA000151 2

External Ids:    HGNC: 28891   Entrez Gene: 271842   OMIM: 6062715   
ORGUL members:    fRNAdb10:FR030924 FR060184 FR074857      
NCBI:AF222987 AF222981 AF222981    
NONCODE:u1057 u1055 n405466 n342969    
RNAdb:LIT1751    

Export aliases for DISC2 gene to outside databases

Previous GC identifers: GC01U990288 GC01M230016


Summaries
for DISC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DISC2:
DISC2 is thought to specify a noncoding RNA molecule antisense to DISC1 (MIM 605210). Both genes were found to be
disrupted by a translocation in a large schizophrenia (MIM 181500) kindred.(supplied by OMIM, Jul 2002)

Gene Wiki entry for DISC2

fRNAdb sequence ontology for DISC2:
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.

Genomic Views
for DISC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DISC2 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pbx1a   CUTL1   E2F-2   Nkx6-1   E2F-1   E2F   HFH-1   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DISC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.1   HGNC cytogenetic band: 1q42.1

DISC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DISC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M231950:  view genomic region     (about GC identifiers)

Start:
 231,950,372 bp from pter      End:
 231,954,263 bp from pter
Size:
 3,892 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • FR0074857
  • FR0030924
  • FR0060184
  • n342969
  • n405466
231945690 231953274 231960858 chr1

Proteins
for DISC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for DISC2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for DISC2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
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Pathways & Interactions
for DISC2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DISC2

Drugs & Compounds
for DISC2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for DISC2
Search CenterWatch for drugs/clinical trials and news about DISC2 

Transcripts
for DISC2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for DISC2:

Disrupted in schizophrenia 2 (non-protein coding)
Hs.720568  [show with all ESTs]
Unigene Representative Sequence: NR_002227

miRNA
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Inhib. RNA
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Primer
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Additional cDNA sequence: NR_002227.2 
GeneLoc Exon Structure


Expression
for DISC2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for DISC2:RNAdb

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

SOURCE GeneReport for Unigene cluster: Hs.720568
    SABiosciences Custom PCR Arrays for DISC2

Primer
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In Situ
Assay Products: 
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Orthologs
for DISC2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

Paralogs
for DISC2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for DISC2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/119 NCBI SNPs in DISC2 are shown (see all 119)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 1 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs803374851,2
--202437459(+) GTTGTC/TGAGGT 15 -- int12Minor allele frequency- T:0.07CSA WA 120
rs781499171,2
--202439145(+) TGCCTG/TTTAAG 15 -- int10--------
rs1159340971,2
C,F,--202439369(+) CTTGCC/TTACTC 15 -- int11Minor allele frequency- T:0.02WA 118
rs744311971,2
F,--202439821(+) TCCCTC/TTTTCA 15 -- int11Minor allele frequency- T:0.03EA 120
rs27593431,2
H--202440270(-) TCTAAG/AAGTGA 15 -- int14Minor allele frequency- A:0.00NS EA 418
rs1157855391,2
C,F,--202440276(+) TTAGAC/TGTTTT 15 -- int11Minor allele frequency- T:0.03WA 118
rs761940091,2
C,F,--202440277(+) NNNNCG/ATTTTA 15 -- int11Minor allele frequency- A:0.02NA 120
rs754824191,2
C,F,--202440313(+) AGAACC/ATCATA 15 -- int13Minor allele frequency- A:0.07WA 122
rs27388781,2
H--202440453(+) GTTTTT/GGAAAA 15 -- int14Minor allele frequency- G:0.00NS EA 414
rs27388791,2
H--202440481(+) GCTCTT/GGCACA 15 -- int14Minor allele frequency- G:0.00NS EA 418

HapMap Linkage Disequilibrium report for DISC2 (231950372 - 231954263 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for DISC2: --

SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for DISC2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
DISC2 for disorders           About GeneDecksing

OMIM gene information: 606271 605210    
OMIM disorders: 181500  
1 disease for DISC2:    About MalaCards
schizophrenia

Human Genome Epidemiology (HuGE) Navigator: DISC2 (4 documents)

Export disorders for DISC2 gene to outside databases

Publications
for DISC2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DISC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DISC2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. (PubMed id 15478311)1, 3 Millar J.K....Thomson P.A. (2004)
  2. Disruption of two novel genes by a schizophrenia-linked translocation. (PubMed id 10814723)1, 3 Millar J.K....Porteous D.J. (2000)
  3. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
  4. The DISC locus in psychiatric illness. (PubMed id 17912248)1 Chubb J.E....Millar J.K. (2008)
  5. Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia. (PubMed id 18164685)1 Song W....Sommer S.S. (2008)
  6. (PubMed id 15608158)10 
  7. (PubMed id 15608161)10 

External Searches for DISC2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing DISC2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 27184 HGNC: 2889 euGenes: HUgn27184 ECgene: DISC2 H-InvDB: DISC2

Other Databases showing DISC2 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing DISC2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DISC2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DISC2 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for DISC2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DISC2 gene:
Search GeneIP for patents involving DISC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for DISC2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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