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Aliases for DIS3L Gene

Aliases for DIS3L Gene

  • DIS3 Like Exosome 3'-5' Exoribonuclease 2
  • DIS3L1 3 4 6
  • DIS3 Like Exosome 3-5 Exoribonuclease 2 3
  • KIAA1955 4 6
  • DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2
  • DIS3 Mitotic Control Homolog-Like 3
  • DIS3-Like Exonuclease 1 3
  • EC 3.1.13.- 4
  • EC 3.1.13 63

External Ids for DIS3L Gene

Summaries for DIS3L Gene

GeneCards Summary for DIS3L Gene

DIS3L (DIS3 Like Exosome 3'-5' Exoribonuclease) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and 3-5-exoribonuclease activity. An important paralog of this gene is DIS3L2.

UniProtKB/Swiss-Prot for DIS3L Gene

  • Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Gene Wiki entry for DIS3L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIS3L Gene

Genomics for DIS3L Gene

Genomic Location for DIS3L Gene

Start:
66,293,217 bp from pter
End:
66,333,898 bp from pter
Size:
40,682 bases
Orientation:
Plus strand

Genomic View for DIS3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIS3L Gene

Regulatory Elements for DIS3L Gene

Proteins for DIS3L Gene

  • Protein details for DIS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF46-DI3L1_HUMAN
    Recommended name:
    DIS3-like exonuclease 1
    Protein Accession:
    Q8TF46
    Secondary Accessions:
    • Q8N1N8
    • Q8WTU9
    • Q96CM7

    Protein attributes for DIS3L Gene

    Size:
    1054 amino acids
    Molecular mass:
    120787 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms
    SequenceCaution:
    • Sequence=BAB85541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DIS3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DIS3L Gene

Proteomics data for DIS3L Gene at MOPED

Post-translational modifications for DIS3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for DIS3L Gene

Protein Domains for DIS3L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DIS3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF46

UniProtKB/Swiss-Prot:

DI3L1_HUMAN
Family:
  • Belongs to the RNR ribonuclease family.:
    • Q8TF46
genes like me logo Genes that share domains with DIS3L: view

No data available for Gene Families for DIS3L Gene

Function for DIS3L Gene

Molecular function for DIS3L Gene

UniProtKB/Swiss-Prot Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Enzyme Numbers (IUBMB) for DIS3L Gene

Gene Ontology (GO) - Molecular Function for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IMP 20531386
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 20531386
GO:0019899 enzyme binding IPI 20531386
genes like me logo Genes that share ontologies with DIS3L: view

Phenotypes for DIS3L Gene

GenomeRNAi human phenotypes for DIS3L:
genes like me logo Genes that share phenotypes with DIS3L: view

miRNA for DIS3L Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DIS3L Gene

Localization for DIS3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIS3L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIS3L Gene COMPARTMENTS Subcellular localization image for DIS3L gene
Compartment Confidence
cytoskeleton 4
plasma membrane 4
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) IBA --
GO:0000177 cytoplasmic exosome (RNase complex) IDA 20531386
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with DIS3L: view

Pathways for DIS3L Gene

SuperPathways for DIS3L Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with DIS3L: view

Pathways by source for DIS3L Gene

1 KEGG pathway for DIS3L Gene

Gene Ontology (GO) - Biological Process for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0006402 mRNA catabolic process IBA --
GO:0016075 rRNA catabolic process IMP 20368444
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IMP 20531386
genes like me logo Genes that share ontologies with DIS3L: view

Transcripts for DIS3L Gene

Unigene Clusters for DIS3L Gene

DIS3 mitotic control homolog (S. cerevisiae)-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIS3L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - -
SP2: -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - -
SP9:
SP10: -
SP11:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for DIS3L Gene

GeneLoc Exon Structure for
DIS3L
ECgene alternative splicing isoforms for
DIS3L

Expression for DIS3L Gene

mRNA expression in normal human tissues for DIS3L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIS3L Gene

SOURCE GeneReport for Unigene cluster for DIS3L Gene Hs.446251

genes like me logo Genes that share expressions with DIS3L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DIS3L Gene

Orthologs for DIS3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIS3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIS3L 35
  • 99.46 (n)
  • 99.72 (a)
DIS3L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DIS3L 35
  • 88.66 (n)
  • 91.96 (a)
DIS3L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DIS3L 35
  • 89.73 (n)
  • 92.87 (a)
DIS3L 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dis3l 35
  • 86.6 (n)
  • 91.9 (a)
Dis3l 16
Dis3l 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DIS3L 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DIS3L 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dis3l 35
  • 85.96 (n)
  • 91.56 (a)
chicken
(Gallus gallus)
Aves DIS3L 35
  • 75.14 (n)
  • 79.67 (a)
DIS3L 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DIS3L 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3437 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dis3l 35
  • 67.01 (n)
  • 70.46 (a)
Str.941 35
zebrafish
(Danio rerio)
Actinopterygii dis3l 35
  • 62.74 (n)
  • 65.02 (a)
dis3l 36
  • 63 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIS3 36
  • 32 (a)
OneToMany
Species with no ortholog for DIS3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DIS3L Gene

ENSEMBL:
Gene Tree for DIS3L (if available)
TreeFam:
Gene Tree for DIS3L (if available)

Paralogs for DIS3L Gene

Paralogs for DIS3L Gene

Selected SIMAP similar genes for DIS3L Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with DIS3L: view

Variants for DIS3L Gene

Sequence variations from dbSNP and Humsavar for DIS3L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs750295 -- 66,320,480(-) AATAC(G/T)GGGTT intron-variant
rs750296 -- 66,320,387(-) AGATG(A/G)TATGA intron-variant
rs755475 -- 66,319,794(+) CACCT(G/T)CTTCT intron-variant
rs873165 -- 66,315,852(+) cccca(C/T)tgcct intron-variant
rs873166 -- 66,315,910(+) caGGG(G/T)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIS3L Gene

Variant ID Type Subtype PubMed ID
nsv833045 CNV Gain 17160897

Relevant External Links for DIS3L Gene

HapMap Linkage Disequilibrium report
DIS3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIS3L Gene

Disorders for DIS3L Gene

Relevant External Links for DIS3L

Genetic Association Database (GAD)
DIS3L
genes like me logo Genes that share disorders with DIS3L: view

No data available for UniProtKB/Swiss-Prot for DIS3L Gene

Publications for DIS3L Gene

  1. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PMID: 20531386) Tomecki R. … Jensen T.H. (EMBO J. 2010) 2 3 4
  2. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals R.H. … Pruijn G.J. (EMBO J. 2010) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DIS3L Gene

Sources for DIS3L Gene

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