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DIS3L Gene

protein-coding   GIFtS: 59
GCID: GC15P066585

DIS3 Like Exosome 3'-5' Exoribonuclease

(Previous name: DIS3 mitotic control homolog (S. cerevisiae)-like)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DIS3 Like Exosome 3'-5' Exoribonuclease1 2     DIS3 Mitotic Control Homolog-Like2
DIS3L12 3 5     DIS3-Like Exonuclease 12
KIAA19553 5     EC 3.1.13.-3
DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like1     EC 3.1.138

External Ids:    HGNC: 286981   Entrez Gene: 1157522   Ensembl: ENSG000001669387   OMIM: 6141835   UniProtKB: Q8TF463   

Export aliases for DIS3L gene to outside databases

Previous GC identifers: GC15P064373 GC15P043422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DIS3L Gene:
DIS3L (DIS3 like exosome 3'-5' exoribonuclease) is a protein-coding gene. GO annotations related to this gene include 3'-5'-exoribonuclease activity and RNA binding. An important paralog of this gene is DIS3.

UniProtKB/Swiss-Prot: DI3L1_HUMAN, Q8TF46
Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5'
exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In
the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently
unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance
pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA

Gene Wiki entry for DIS3L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DIS3L gene promoter:
         S8   Sox5   HFH-1   Lmo2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DIS3L promoter sequence
   Search Chromatin IP Primers for DIS3L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DIS3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

DIS3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIS3L gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P066585:  view genomic region     (about GC identifiers)

Start:
66,585,555 bp from pter      End:
66,626,236 bp from pter
Size:
40,682 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DI3L1_HUMAN, Q8TF46 (See protein sequence)
Recommended Name: DIS3-like exonuclease 1  
Size: 1054 amino acids; 120787 Da
Cofactor: Magnesium
Subunit: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is
believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA
exosome complex forms
Sequence caution: Sequence=BAB85541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8N1N8 Q8WTU9 Q96CM7
Alternative splicing: 4 isoforms:  Q8TF46-1   Q8TF46-2   Q8TF46-3   Q8TF46-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DIS3L: NX_Q8TF46

Explore proteomics data for DIS3L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DIS3L (Q8TF46) (see all 28)
     VNKHRAQ  VREHYLR  RFGIKGA  GVHIADV 


    See DIS3L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137160.1  NP_588616.1  

    ENSEMBL proteins: 
     ENSP00000321583   ENSP00000435792   ENSP00000433504   ENSP00000321711   ENSP00000432125  
     ENSP00000436583   ENSP00000436573   ENSP00000432407   ENSP00000388980  

    DIS3L Human Recombinant Protein Products:

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    Novus Biologicals DIS3L Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DIS3L

     
    Search eBioscience for Proteins for DIS3L 

     
    antibodies-online proteins for DIS3L (2 products) 

     
    Search antibodies-online for peptides for DIS3L

    DIS3L Antibody Products:

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    antibodies-online antibodies for DIS3L (21 products) 

    DIS3L Assay Products:

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    Cloud-Clone Corp. ELISAs for DIS3L
    Cloud-Clone Corp. CLIAs for DIS3L
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    antibodies-online kits for DIS3L (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022966 RNase_II/R_CS
     IPR012340 NA-bd_OB-fold

    Graphical View of Domain Structure for InterPro Entry Q8TF46

    ProtoNet protein and cluster: Q8TF46

    1 Blocks protein domain: IPB001900 Ribonuclease II

    UniProtKB/Swiss-Prot: DI3L1_HUMAN, Q8TF46
    Similarity: Belongs to the RNR ribonuclease family


    Find genes that share domains with DIS3L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DI3L1_HUMAN, Q8TF46
    Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5'
    exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In
    the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently
    unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance
    pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA

         Enzyme Numbers (IUBMB): EC 3.1.13.-1 EC 3.1.132

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IMP--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0019899enzyme binding IPI--
         
    Find genes that share ontologies with DIS3L           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DIS3L:
     Wnt reporter downregulated 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DIS3L

    miRNA
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    miRTarBase miRNAs that target DIS3L:
    hsa-mir-192-5p (MIRT026419), hsa-mir-18a-3p (MIRT040874), hsa-mir-215-5p (MIRT024295), hsa-mir-671-3p (MIRT037770)

    Block miRNA regulation of human, mouse, rat DIS3L using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat DIS3L

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    GenScript: all cDNA clones in your preferred vector (see all 2): DIS3L (NM_001143688)
    Sino Biological Human cDNA Clone for DIS3L
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIS3L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIS3L

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DI3L1_HUMAN, Q8TF46: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    plasma membrane4
    cytosol3
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000177cytoplasmic exosome (RNase complex) IDA--
    GO:0005737cytoplasm ----
    GO:0005813centrosome ----
    GO:0005886plasma membrane ----

    Find genes that share ontologies with DIS3L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DIS3L About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48


    Find genes that share SuperPaths with DIS3L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for DIS3L):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DIS3L
    Interactions:

        Search GeneGlobe Interaction Network for DIS3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DIS3L (Q8TF461, 2, 3 ENSP000003217114) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC2Q138681, 2, ENSP000003614334EBI-3895807,EBI-301735 MINT-7993644 MINT-7993893 MINT-7988341 MINT-7993837 MINT-7988296 STRING: ENSP00000361433
    EXOSC3Q9NQT52, 3, ENSP000003230464MINT-7993644 MINT-7993837 MINT-7988296 MINT-7988352 I2D: score=1 STRING: ENSP00000323046
    EXOSC8Q96B262, ENSP000003743544MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 STRING: ENSP00000374354
    EXOSC4Q9NPD32, ENSP000003154764MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 STRING: ENSP00000315476
    EXOSC1Q9Y3B22, ENSP000003599394MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 STRING: ENSP00000359939
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016075rRNA catabolic process IMP--
    GO:0090503RNA phosphodiester bond hydrolysis, exonucleolytic IMP--

    Find genes that share ontologies with DIS3L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DIS3L (DI3L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DIS3L gene (2 alternative transcripts): 
    NM_001143688.1  NM_133375.3  

    Unigene Cluster for DIS3L:

    DIS3 mitotic control homolog (S. cerevisiae)-like
    Hs.446251  [show with all ESTs]
    Unigene Representative Sequence: NM_001143688
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319194(uc010ujl.1 uc002app.3 uc010bho.3) ENST00000525134
    ENST00000524795 ENST00000565281 ENST00000319212(uc010ujm.2) ENST00000564909(uc002apq.2)
    ENST00000525109 ENST00000532580 ENST00000532293 ENST00000530615 ENST00000530537
    ENST00000562314 ENST00000564945 ENST00000568874 ENST00000441424
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DIS3L
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    Primer
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    OriGene qPCR primer pairs and template standards for DIS3L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DIS3L
      QuantiTect SYBR Green Assays in human, mouse, rat DIS3L
      QuantiFast Probe-based Assays in human, mouse, rat DIS3L

    Additional mRNA sequence: 

    AB075835.1 AK095407.1 AK123202.1 AK295392.1 BC014124.2 BC022089.2 

    12 DOTS entries:

    DT.97842322  DT.92419777  DT.100779083  DT.121067801  DT.121067836  DT.101968464  DT.121067845  DT.40207844 
    DT.95267271  DT.75147816  DT.95134264  DT.95246224 

    Selected AceView cDNA sequences (see all 104):

    BQ948533 BU179361 AK095407 BG028689 BP337679 BC022089 AW675272 BX091524 
    CA396619 BM667083 BM480303 BF968274 AA665192 BP340216 BU173770 AI460036 
    AV703252 BC014124 AI352615 AI184226 BP360644 NM_133375 CB132382 BE674881 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DIS3L (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
    SP1:                          -                 -                                                                                                               
    SP2:                          -                                                                                                                                 
    SP3:              -     -     -                 -                                                                                                               
    SP4:                                                                                                                                      -                     
    SP5:                                            -                 -                                                                                             

    ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for DIS3L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DIS3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCGTAAG
    DIS3L Expression
    About this image

    DIS3L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DIS3L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446251
        Custom PCR Arrays for DIS3L
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DIS3L gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dis3l1 , 5 DIS3 mitotic control homolog (S. cerevisiae)-like1, 5 86.6(n)1
    91.9(a)1
      9 (34.62 cM)5
    2135501  NM_001001295.21  NP_001001295.21 
     643067575 
    chicken
    (Gallus gallus)
    Aves DIS3L1 DIS3 mitotic control homolog (S. cerevisiae)-like 75.14(n)
    79.67(a)
      100857630  XM_003641827.2  XP_003641875.2 
    lizard
    (Anolis carolinensis)
    Reptilia DIS3L6
    DIS3 mitotic control homolog (S. cerevisiae)-like
    66(a)
    1 ↔ 1
    GL343671.1(11583-33200)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34372 Xenopus laevis transcribed sequence with weak similarity more 75.22(n)    BX852048.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dis3l1 DIS3 mitotic control homolog (S. cerevisiae)-like 62.74(n)
    65.02(a)
      560362  NM_001110458.1  NP_001103928.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIS36
    Exosome core complex catalytic subunit; possesses ...
    32(a)
    1 → many
    XV(282421-285426) YOL021C


    ENSEMBL Gene Tree for DIS3L (if available)
    TreeFam Gene Tree for DIS3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DIS3L gene
    DIS32  DIS3L22  
    2 SIMAP similar genes for DIS3L using alignment to 8 protein entries:     DI3L1_HUMAN (see all proteins):
    FLJ00327    DIS3

    Find genes that share paralogs with DIS3L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DIS3L (see all 972)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405327901,2
    --66583645(+) TACAAG/TTATAG 1 -- us2k10--------
    rs1134902141,2
    C--66583694(+) AGGCA-/AACC  
            
    AACCA
    1 -- us2k11Minor allele frequency- AACC:0.50CSA 2
    rs665535641,2
    C,F--66583920(+) ATTTGA/TCCCAA 2 -- us2k16Minor allele frequency- T:0.29WA NA CSA 246
    rs1871824951,2
    --66583974(+) ATGGGC/TATATT 2 -- us2k10--------
    rs600435601,2
    C--66583995(+) CCCCC-/CCATAAC 2 -- us2k11Minor allele frequency- CC:0.00NA 2
    rs1503932361,2
    C--66584026(+) ATCAGA/CAATAA 2 -- us2k10--------
    rs1498512901,2
    C--66584069(+) ACTGT-/GGTCA 
            
    GGTCA
    2 -- us2k10--------
    rs1900219591,2
    --66584299(+) GAGATC/TGTGGC 2 -- us2k10--------
    rs2008501481,2
    C--66584382(+) ATCAC-/GGAAGT 2 -- us2k10--------
    rs71688911,2
    C,F,A,H--66584393(+) CTGATG/ATTTCC 2 -- us2k110Minor allele frequency- A:0.03NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for DIS3L (66585555 - 66626236 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DIS3L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833045CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DIS3L
    DNA2.0 Custom Variant and Variant Library Synthesis for DIS3L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614183    OMIM disorders: --


    Find genes that share disorders with DIS3L           About GenesLikeMe

    Genetic Association Database (GAD): DIS3L

    Export disorders for DIS3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DIS3L gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DIS3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PubMed id 20531386)1, 2, 3 Tomecki R.... Jensen T.H. (EMBO J. 2010)
    2. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H.... Pruijn G.J. (EMBO J. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 115752 HGNC: 28698 AceView: MGC4562 Ensembl:ENSG00000166938 euGenes: HUgn115752
    ECgene: DIS3L Kegg: 115752 H-InvDB: DIS3L

    (According to HUGE)
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    HUGE: KIAA1955

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DIS3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DIS3L gene:
    Search GeneIP for patents involving DIS3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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