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Aliases for DIS3L Gene

Aliases for DIS3L Gene

  • DIS3 Like Exosome 3'-5' Exoribonuclease 2
  • DIS3 Like Exosome 3-5 Exoribonuclease 2 3 5
  • DIS3L1 3 4
  • DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2
  • DIS3 Mitotic Control Homolog-Like 3
  • DIS3-Like Exonuclease 1 3
  • EC 3.1.13.- 4
  • EC 3.1.13 58
  • KIAA1955 4

External Ids for DIS3L Gene

Previous GeneCards Identifiers for DIS3L Gene

  • GC15P064373
  • GC15P066585
  • GC15P043422

Summaries for DIS3L Gene

Entrez Gene Summary for DIS3L Gene

  • The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

GeneCards Summary for DIS3L Gene

DIS3L (DIS3 Like Exosome 3'-5' Exoribonuclease) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and 3-5-exoribonuclease activity. An important paralog of this gene is DIS3.

UniProtKB/Swiss-Prot for DIS3L Gene

  • Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Gene Wiki entry for DIS3L Gene

Additional gene information for DIS3L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIS3L Gene

Genomics for DIS3L Gene

Regulatory Elements for DIS3L Gene

Enhancers for DIS3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H066829 1.4 Ensembl ENCODE dbSUPER 25.3 +539.9 539901 6 ZNF473 ZSCAN4 RAD21 ZBTB40 ZNF302 SCRT2 RCOR1 KLF7 EGR2 MCM3 DIS3L SKOR1 TIPIN SNORD16 ZWILCH SNAPC5 MAP2K1 LOC105370869 LETM1P1
GH15H065609 1.2 ENCODE 24.7 -681.8 -681805 3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 INTS14 PARP16 ENSG00000260773 SNORD16 PDCD7 RPL35AP32 ENSG00000264937 ENSG00000259635 SLC24A1 TIPIN
GH15H066400 1.3 Ensembl ENCODE dbSUPER 18.9 +110.4 110445 6 HDGF BMI1 ETS1 ZNF366 SCRT2 ETV6 RUNX3 IKZF2 SMARCA5 YY2 TIPIN DIS3L SNAPC5 RPL4 SNORD18C SNORD18B SNORD18A SNORD16 ZWILCH GC15M066415
GH15H066502 1.4 ENCODE dbSUPER 17.2 +211.0 211001 4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B INTS14 TIPIN ENSG00000260773 SNAPC5 SNORD16 DIS3L RPL35AP32 ZWILCH RPL4 HACD3
GH15H067100 2 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +812.9 812862 11 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DIS3L SMAD3 GC15P068910 GC15P068195
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DIS3L on UCSC Golden Path with GeneCards custom track

Promoters for DIS3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078160 483 1401 SIN3A FEZF1 DMAP1 GLI4 ZNF2 YY1 ZNF121 GLIS2 CBX5 ELK1

Genomic Location for DIS3L Gene

Chromosome:
15
Start:
66,293,217 bp from pter
End:
66,333,898 bp from pter
Size:
40,682 bases
Orientation:
Plus strand

Genomic View for DIS3L Gene

Genes around DIS3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIS3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIS3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIS3L Gene

Proteins for DIS3L Gene

  • Protein details for DIS3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF46-DI3L1_HUMAN
    Recommended name:
    DIS3-like exonuclease 1
    Protein Accession:
    Q8TF46
    Secondary Accessions:
    • Q8N1N8
    • Q8WTU9
    • Q96CM7

    Protein attributes for DIS3L Gene

    Size:
    1054 amino acids
    Molecular mass:
    120787 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
    SequenceCaution:
    • Sequence=BAB85541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DIS3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DIS3L Gene

Selected DME Specific Peptides for DIS3L Gene

Q8TF46:
  • HPPPHQEFFSELRECAKAKGFFIDTRSNK
  • AECMILANHWVAKKIWE
  • LFANEFQQ
  • PKQPLEVHETVAECMI
  • QTKGRSLYTLLEEIRDLALLDVS
  • LFDHVTVRI
  • GVHIADV
  • GRTIIRS
  • PTGRVVGI
  • YTHFTSPIRRY
  • QSRRERE
  • VQHQRGRRQY
  • VNKHRAQ
  • RATTYYLADRR
  • GCEDVDDTLSVR
  • DIVVHRLL
  • FHHYGLA
  • QKQSTELFQCM
  • HLVFSIDPKGCEDVDD
  • ELFQCMYF
  • DRMPIVMVTEDEEAIQ
  • VREHYLR
  • RFGIKGA
  • KARNRSIHGDVVVVE
  • MATQAMSNA
  • LEAGIKSGRY
  • SEWKPGSLQR
  • NKDLEELCRHIN

Post-translational modifications for DIS3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DIS3L Gene

Gene Families for DIS3L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DIS3L Gene

Suggested Antigen Peptide Sequences for DIS3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF46

UniProtKB/Swiss-Prot:

DI3L1_HUMAN :
  • Belongs to the RNR ribonuclease family.
Family:
  • Belongs to the RNR ribonuclease family.
genes like me logo Genes that share domains with DIS3L: view

Function for DIS3L Gene

Molecular function for DIS3L Gene

UniProtKB/Swiss-Prot Function:
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

Enzyme Numbers (IUBMB) for DIS3L Gene

Phenotypes From GWAS Catalog for DIS3L Gene

Gene Ontology (GO) - Molecular Function for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IMP 20531386
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0005515 protein binding IPI 20531386
genes like me logo Genes that share ontologies with DIS3L: view

Phenotypes for DIS3L Gene

genes like me logo Genes that share phenotypes with DIS3L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DIS3L

CRISPR Products

miRNA for DIS3L Gene

miRTarBase miRNAs that target DIS3L

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DIS3L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIS3L Gene

Localization for DIS3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIS3L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DIS3L gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000177 cytoplasmic exosome (RNase complex) IDA 20531386
GO:0000178 exosome (RNase complex) IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DIS3L: view

Pathways & Interactions for DIS3L Gene

SuperPathways for DIS3L Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with DIS3L: view

Pathways by source for DIS3L Gene

1 KEGG pathway for DIS3L Gene

Gene Ontology (GO) - Biological Process for DIS3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0016075 rRNA catabolic process IEA,IMP 20368444
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with DIS3L: view

No data available for SIGNOR curated interactions for DIS3L Gene

Drugs & Compounds for DIS3L Gene

No Compound Related Data Available

Transcripts for DIS3L Gene

Unigene Clusters for DIS3L Gene

DIS3 mitotic control homolog (S. cerevisiae)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DIS3L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DIS3L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
SP1: - -
SP2: -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - -
SP9:
SP10: -
SP11:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for DIS3L Gene

GeneLoc Exon Structure for
DIS3L
ECgene alternative splicing isoforms for
DIS3L

Expression for DIS3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DIS3L Gene

Protein differential expression in normal tissues from HIPED for DIS3L Gene

This gene is overexpressed in Heart (22.7), Peripheral blood mononuclear cells (12.0), and Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIS3L Gene



Protein tissue co-expression partners for DIS3L Gene

NURSA nuclear receptor signaling pathways regulating expression of DIS3L Gene:

DIS3L

SOURCE GeneReport for Unigene cluster for DIS3L Gene:

Hs.446251

Evidence on tissue expression from TISSUES for DIS3L Gene

  • Nervous system(4.3)
  • Kidney(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with DIS3L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DIS3L Gene

Orthologs for DIS3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIS3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIS3L 33 34
  • 99.46 (n)
oppossum
(Monodelphis domestica)
Mammalia DIS3L 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DIS3L 33 34
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia DIS3L 33 34
  • 88.66 (n)
mouse
(Mus musculus)
Mammalia Dis3l 33 16 34
  • 86.6 (n)
rat
(Rattus norvegicus)
Mammalia Dis3l 33
  • 85.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DIS3L 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIS3L 33 34
  • 75.14 (n)
lizard
(Anolis carolinensis)
Reptilia DIS3L 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dis3l 33
  • 67.01 (n)
Str.941 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3437 33
zebrafish
(Danio rerio)
Actinopterygii dis3l 33 34
  • 62.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIS3 34
  • 32 (a)
OneToMany
Species where no ortholog for DIS3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DIS3L Gene

ENSEMBL:
Gene Tree for DIS3L (if available)
TreeFam:
Gene Tree for DIS3L (if available)

Paralogs for DIS3L Gene

Paralogs for DIS3L Gene

(2) SIMAP similar genes for DIS3L Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with DIS3L: view

Variants for DIS3L Gene

Sequence variations from dbSNP and Humsavar for DIS3L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs193920782 Uncertain significance 66,333,236(+) AAAGG(A/G)AAGGA reference, missense
rs1000019122 -- 66,323,947(+) GGGAG(G/T)TTTTT intron-variant
rs1000098313 -- 66,321,444(+) GGGCA(C/T)TCAGC intron-variant
rs1000223584 -- 66,330,285(+) GAGCG(A/C)AACTC intron-variant, utr-variant-3-prime
rs1000285248 -- 66,296,061(+) TAAAT(G/T)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIS3L Gene

Variant ID Type Subtype PubMed ID
nsv1047176 CNV gain 25217958
nsv1047588 CNV loss 25217958
nsv1055090 CNV gain 25217958
nsv1122978 CNV deletion 24896259
nsv1134462 CNV deletion 24896259
nsv569793 CNV gain 21841781
nsv833045 CNV gain 17160897

Variation tolerance for DIS3L Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIS3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIS3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIS3L Gene

Disorders for DIS3L Gene

Relevant External Links for DIS3L

Genetic Association Database (GAD)
DIS3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIS3L

No disorders were found for DIS3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIS3L Gene

Publications for DIS3L Gene

  1. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PMID: 20531386) Tomecki R … Jensen TH (The EMBO journal 2010) 2 3 4 60
  2. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for DIS3L Gene

Sources for DIS3L Gene

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