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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DIS3L Gene

protein-coding   GIFtS: 56
GCID: GC15P066585

DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like1 2
DIS3L12 3
DIS3-Like Exonuclease 12
EC 3.1.13.-3
KIAA19553
EC 3.1.138

External Ids:    HGNC: 286981   Entrez Gene: 1157522   Ensembl: ENSG000001669387   OMIM: 6141835   UniProtKB: Q8TF463   

Export aliases for DIS3L gene to outside databases

Previous GC identifers: GC15P064373 GC15P043422


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DIS3L Gene: 
DIS3L (DIS3 mitotic control homolog (S. cerevisiae)-like) is a protein-coding gene. Diseases associated with DIS3L include pneumonia, and gastric cancer. GO annotations related to this gene include 3'-5'-exoribonuclease activity and RNA binding. An important paralog of this gene is DIS3.

UniProtKB/Swiss-Prot: DI3L1_HUMAN, Q8TF46
Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5'
exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In
the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently
unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance
pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA

Gene Wiki entry for DIS3L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DIS3L gene promoter:
         S8   Sox5   HFH-1   Lmo2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DIS3L promoter sequence
   Search SABiosciences Chromatin IP Primers for DIS3L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIS3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

DIS3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIS3L gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P066585:  view genomic region     (about GC identifiers)

Start:
66,585,555 bp from pter      End:
66,626,236 bp from pter
Size:
40,682 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DI3L1_HUMAN, Q8TF46 (See protein sequence)
Recommended Name: DIS3-like exonuclease 1  
Size: 1054 amino acids; 120787 Da
Cofactor: Magnesium
Subunit: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is
believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA
exosome complex forms
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAB85541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8N1N8 Q8WTU9 Q96CM7
Alternative splicing: 4 isoforms:  Q8TF46-1   Q8TF46-2   Q8TF46-3   Q8TF46-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DIS3L: NX_Q8TF46

Explore proteomics data for DIS3L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TF46

  • 4/28 DME Specific Peptides for DIS3L (Q8TF46) (see all 28)
     VNKHRAQ  VREHYLR  RFGIKGA  GVHIADV 

    DIS3L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DIS3L Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137160.1  NP_588616.1  

    ENSEMBL proteins: 
     ENSP00000321583   ENSP00000435792   ENSP00000433504   ENSP00000321711   ENSP00000432125  
     ENSP00000436583   ENSP00000436573   ENSP00000432407   ENSP00000388980  

    Human Recombinant Protein Products for DIS3L: 
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    Novus Biologicals DIS3L Protein
    Novus Biologicals DIS3L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DIS3L 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000177cytoplasmic exosome (RNase complex) IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005886plasma membrane IDA--

    DIS3L for ontologies           About GeneDecksing



    DIS3L Antibody Products: 
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    ThermoFisher Antibodies for DIS3L
    LSBio Antibodies in human, mouse, rat for DIS3L 

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    Cloud-Clone Corp. ELISAs for DIS3L 
    Cloud-Clone Corp. CLIAs for DIS3L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR022966 RNase_II/R_CS
     IPR001900 RNase_II/R

    Graphical View of Domain Structure for InterPro Entry Q8TF46

    ProtoNet protein and cluster: Q8TF46

    1 Blocks protein domain: IPB001900 Ribonuclease II

    UniProtKB/Swiss-Prot: DI3L1_HUMAN, Q8TF46
    Similarity: Belongs to the RNR ribonuclease family


    DIS3L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DI3L1_HUMAN, Q8TF46
    Function: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5'
    exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In
    the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently
    unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance
    pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA

         Enzyme Numbers (IUBMB): EC 3.1.13.-1 EC 3.1.132

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IMP--
    GO:0003723RNA binding IEA--
    GO:0004540ribonuclease activity ----
    GO:0005515protein binding IPI--
    GO:0019899enzyme binding IPI--
         
    DIS3L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DIS3L:
     Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DIS3L 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DIS3L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DIS3L 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DIS3L 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidDIS3L 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DIS3L

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DIS3L (NM_001143688)
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                         Customized lentivirus expression plasmids for stable overexpression of DIS3L 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DIS3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/33 Interacting proteins for DIS3L (Q8TF461, 2, 3 ENSP000003217114) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC2Q138681, 2, ENSP000003614334EBI-3895807,EBI-301735 MINT-7993644 MINT-7993893 MINT-7988341 MINT-7993837 MINT-7988296 STRING: ENSP00000361433
    EXOSC3Q9NQT52, 3, ENSP000003230464MINT-7993644 MINT-7993837 MINT-7988296 MINT-7988352 I2D: score=1 STRING: ENSP00000323046
    EXOSC8Q96B262, ENSP000003743544MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 STRING: ENSP00000374354
    EXOSC4Q9NPD32, ENSP000003154764MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 STRING: ENSP00000315476
    EXOSC1Q9Y3B22, ENSP000003599394MINT-7993644 MINT-7993893 MINT-7993837 MINT-7988296 STRING: ENSP00000359939
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016075rRNA catabolic process IMP--

    DIS3L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DIS3L (DI3L1)

    Search CenterWatch for drugs/clinical trials and news about DIS3L / DI3L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DIS3L gene (2 alternative transcripts): 
    NM_001143688.1  NM_133375.3  

    Unigene Cluster for DIS3L:

    DIS3 mitotic control homolog (S. cerevisiae)-like
    Hs.446251  [show with all ESTs]
    Unigene Representative Sequence: NM_001143688
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319194(uc010ujl.1 uc002app.3 uc010bho.3) ENST00000525134
    ENST00000524795 ENST00000565281 ENST00000319212(uc010ujm.2) ENST00000564909(uc002apq.2)
    ENST00000525109 ENST00000532580 ENST00000532293 ENST00000530615 ENST00000530537
    ENST00000562314 ENST00000564945 ENST00000568874 ENST00000441424
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DIS3L
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DIS3L
    SwitchGear 3'UTR luciferase reporter plasmidDIS3L 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for DIS3L
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    GenScript: all cDNA clones in your preferred vector (see all 2): DIS3L (NM_001143688)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIS3L
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIS3L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIS3L

    Additional mRNA sequence: 

    AB075835.1 AK095407.1 AK123202.1 AK295392.1 BC014124.2 BC022089.2 

    12 DOTS entries:

    DT.97842322  DT.92419777  DT.100779083  DT.121067801  DT.121067836  DT.101968464  DT.121067845  DT.40207844 
    DT.95267271  DT.75147816  DT.95134264  DT.95246224 

    24/104 AceView cDNA sequences (see all 104):

    CB132382 CA396619 BP360644 BM480303 AW675272 AV703252 BQ948533 AI352615 
    BU179361 BP340216 BP337679 NM_133375 BM667083 BG028689 AA665192 AI460036 
    AI184226 BF968274 BC022089 BC014124 AK095407 BU173770 BX091524 BU951747 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DIS3L (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^
    SP1:                          -                 -                                                                                                               
    SP2:                          -                                                                                                                                 
    SP3:              -     -     -                 -                                                                                                               
    SP4:                                                                                                                                      -                     
    SP5:                                            -                 -                                                                                             

    ExUns: 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for DIS3L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DIS3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCGTAAG
    DIS3L Expression
    About this image


    See DIS3L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DIS3L

    SOURCE GeneReport for Unigene cluster: Hs.446251
        SABiosciences Custom PCR Arrays for DIS3L
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIS3L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DIS3L gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dis3l1 , 5 DIS3 mitotic control homolog (S. cerevisiae)-like1, 5 86.6(n)1
    91.9(a)1
      9 (34.62 cM)5
    2135501  NM_001001295.21  NP_001001295.21 
     643067575 
    chicken
    (Gallus gallus)
    Aves LOC1008576301 DIS3-like exonuclease 1-like 75.3(n)
    79.56(a)
      100857630  XM_003641827.1  XP_003641875.1 
    lizard
    (Anolis carolinensis)
    Reptilia DIS3L6
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343671.1(11583-33200)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34372 Xenopus laevis transcribed sequence with weak similarity more 75.22(n)    BX852048.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dis3l1 DIS3 mitotic control homolog (S. cerevisiae)-like 62.77(n)
    65.02(a)
      560362  NM_001110458.1  NP_001103928.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIS36
    Exosome core complex catalytic subunit; possesses ...
    28(a)
    1 → many
    XV(282421-285426)


    ENSEMBL Gene Tree for DIS3L (if available)
    TreeFam Gene Tree for DIS3L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DIS3L gene
    DIS32  DIS3L22  
    2 SIMAP similar genes for DIS3L using alignment to 8 protein entries:     DI3L1_HUMAN (see all proteins):
    FLJ00327    DIS3

    DIS3L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/972 SNPs in DIS3L are shown (see all 972)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405327901,2
    --66583645(+) TACAAG/TTATAG 1 -- us2k10--------
    rs1134902141,2
    C--66583694(+) AGGCA-/AACC  
            
    AACCA
    1 -- us2k11Minor allele frequency- AACC:0.50CSA 2
    rs665535641,2
    C,F--66583920(+) ATTTGA/TCCCAA 2 -- us2k16Minor allele frequency- T:0.29WA NA CSA 246
    rs1871824951,2
    --66583974(+) ATGGGC/TATATT 2 -- us2k10--------
    rs600435601,2
    C--66583995(+) CCCCC-/CCATAAC 2 -- us2k11Minor allele frequency- CC:0.00NA 2
    rs1503932361,2
    C--66584026(+) ATCAGA/CAATAA 2 -- us2k10--------
    rs1498512901,2
    C--66584069(+) ACTGT-/GGTCA 
            
    GGTCA
    2 -- us2k10--------
    rs1900219591,2
    --66584299(+) GAGATC/TGTGGC 2 -- us2k10--------
    rs2008501481,2
    C--66584382(+) ATCAC-/GGAAGT 2 -- us2k10--------
    rs71688911,2
    C,F,A,H--66584393(+) CTGATG/ATTTCC 2 -- us2k110Minor allele frequency- A:0.03NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for DIS3L (66585555 - 66626236 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DIS3L:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833045CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614183    OMIM disorders: --

    2 diseases for DIS3L:    About MalaCards
    pneumonia    gastric cancer


    DIS3L for disorders           About GeneDecksing

    Genetic Association Database (GAD): DIS3L

    Export disorders for DIS3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DIS3L gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with DIS3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PubMed id 20531386)1, 2, 3 Tomecki R....Jensen T.H. (2010)
    2. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115752 HGNC: 28698 AceView: MGC4562 Ensembl:ENSG00000166938 euGenes: HUgn115752
    ECgene: DIS3L H-InvDB: DIS3L

    (According to HUGE)
    About This Section
    HUGE: KIAA1955

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DIS3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DIS3L gene:
    Search GeneIP for patents involving DIS3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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