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DIS3 Gene

protein-coding   GIFtS: 61
GCID: GC13M073329

DIS3 Exosome Endoribonuclease And 3'-5' Exoribonuclease

(Previous names: KIAA1008, DIS3 mitotic control homolog (S. cerevisiae))
(Previous symbol: KIAA1008)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DIS3 Exosome Endoribonuclease And 3'-5' Exoribonuclease1 2     DIS3 Mitotic Control Homolog2
KIAA10081 2 3 5     dis3p2
Exosome Component 111 2     Exosome Complex Exonuclease RRP442
Ribosomal RNA-Processing Protein 442 3     Mitotic Control Protein Dis3 Homolog2
RRP442 3     EC 3.1.13.-3
DIS3 Mitotic Control Homolog (S. Cerevisiae)1     EC 3.1.26.-3
2810028N01Rik2     Protein DIS3 Homolog3
EXOSC112     EC 3.1.138

External Ids:    HGNC: 206041   Entrez Gene: 228942   Ensembl: ENSG000000835207   OMIM: 6075335   UniProtKB: Q9Y2L13   

Export aliases for DIS3 gene to outside databases

Previous GC identifers: GC13M071296 GC13M067324 GC13M072266 GC13M071127 GC13M054026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DIS3 Gene:
DIS3 (DIS3 exosome endoribonuclease and 3'-5' exoribonuclease) is a protein-coding gene. Diseases associated with DIS3 include nodular malignant melanoma, and pneumonia. GO annotations related to this gene include RNA binding and endonuclease activity. An important paralog of this gene is DIS3L.

UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1
Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities

Gene Wiki entry for DIS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DIS3 gene promoter:
         AhR   Pax-5   GATA-3   p53   Brachyury   C/EBPalpha   Arnt   GATA-2   N-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDIS3 promoter sequence
   Search Chromatin IP Primers for DIS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DIS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.1   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q21.32

DIS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIS3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M073329:  view genomic region     (about GC identifiers)

Start:
73,329,540 bp from pter      End:
73,356,344 bp from pter
Size:
26,805 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1 (See protein sequence)
Recommended Name: Exosome complex exonuclease RRP44  
Size: 958 amino acids; 109003 Da
Cofactor: Magnesium or manganese
Subunit: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is
believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA
exosome complex forms
Miscellaneous: The association of DIS3 with the RNA exosome complex appears to be weak explaining its absence in
some complex purifications
Sequence caution: Sequence=BAA76852.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NI21 B2RBL2 Q5W0P7 Q5W0P8 Q658Z7 Q7Z481 Q8WWI2 Q9UG36
Alternative splicing: 2 isoforms:  Q9Y2L1-1   Q9Y2L1-2   

Explore the universe of human proteins at neXtProt for DIS3: NX_Q9Y2L1

Explore proteomics data for DIS3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys118, Lys199, Lys236, Lys242, Lys462, Lys815, Lys922
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DIS3 (Q9Y2L1) (see all 8)
     VREHYLR  FHHYGLA  GVHIADV  NKEKAIE 


    See DIS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121698.1  NP_055768.3  

    ENSEMBL proteins: 
     ENSP00000366997   ENSP00000367011   ENSP00000436350   ENSP00000440058  
    Reactome Protein details: Q9Y2L1

    DIS3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals DIS3 Protein
    Novus Biologicals DIS3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DIS3

    DIS3 Antibody Products:

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    Novus Biologicals DIS3 Antibodies
    Abcam antibodies for DIS3
    Cloud-Clone Corp. Antibodies for DIS3
    ThermoFisher Antibodies for DIS3
    LSBio Antibodies in human, mouse, rat for DIS3

    DIS3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DIS3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DIS3
    Cloud-Clone Corp. CLIAs for DIS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR022966 RNase_II/R_CS
     IPR012340 NA-bd_OB-fold
     IPR002716 PIN_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2L1

    ProtoNet protein and cluster: Q9Y2L1

    2 Blocks protein domains:
    IPB001900 Ribonuclease II
    IPB006596 Nucleotide binding protein


    UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1
    Similarity: Belongs to the RNR ribonuclease family
    Similarity: Contains 1 PINc domain


    DIS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRP44_HUMAN, Q9Y2L1
    Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and
    participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome
    complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination
    of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and
    promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding
    their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig
    variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA
    substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically
    degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and
    in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of
    histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities

         Enzyme Numbers (IUBMB): EC 3.1.13.-1 EC 3.1.132 EC 3.1.26.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IMP--
    GO:0003723RNA binding IEA--
    GO:0004519endonuclease activity IMP--
    GO:0005085guanyl-nucleotide exchange factor activity IDA9562621
    GO:0005515protein binding IPI15231747
         
    DIS3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DIS3:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Dis3 (no phenotypes)

    DIS3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DIS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DIS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DIS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DIS3

    miRNA
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    miRTarBase miRNAs that target DIS3:
    hsa-mir-26b-5p (MIRT028852), hsa-mir-124-3p (MIRT022253), hsa-mir-30c-5p (MIRT047998)

    Block miRNA regulation of human, mouse, rat DIS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DIS3 (see all 45):
    hsa-miR-548j hsa-miR-136 hsa-miR-4272 hsa-miR-200a hsa-miR-374a* hsa-miR-141 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidDIS3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DIS3
    Predesigned siRNA for gene silencing in human, mouse, rat DIS3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DIS3

    Clone
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    OriGene clones in human, mouse for DIS3 (see all 12)
    OriGene ORF clones in mouse, rat for DIS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DIS3 (NM_014953)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIS3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DIS3
    Browse ESI BIO Cell Lines and PureStem Progenitors for DIS3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RRP44_HUMAN, Q9Y2L1: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in
    the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from
    nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000176nuclear exosome (RNase complex) IDA--
    GO:0000178exosome (RNase complex) TAS9562621
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA--
    GO:0005730NOT nucleolus IDA--

    DIS3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DIS3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 3 to 5' Exoribonuclease0.00
    RNA degradation0.48
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Destabilization of mRNA by KSRP0.00
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.00
    Destabilization of mRNA by Tristetraprolin (TTP)0.00
    3PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    4Unfolded Protein Response
    Unfolded Protein Response0.61
    5Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DIS3
        ATP/ITP metabolism

    5 Reactome Pathways for DIS3
        Tristetraprolin (TTP) destabilizes mRNA
    Butyrate Response Factor 1 (BRF1) destabilizes mRNA
    KSRP destabilizes mRNA
    mRNA decay by 3' to 5' exoribonuclease
    ATF4 activates genes


    1 Kegg Pathway  (Kegg details for DIS3):
        RNA degradation


    DIS3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DIS3
    Interactions:

        GeneGlobe Interaction Network for DIS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DIS3 (Q9Y2L11, 2, 3 ENSP000003669974) via UniProtKB, MINT, STRING, and/or I2D (see all 289)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006364rRNA processing TAS9562621
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    DIS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DIS3 (RRP44)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DIS3 gene (2 alternative transcripts): 
    NM_001128226.2  NM_014953.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377767(uc001viy.4 uc001vix.4) ENST00000377780 ENST00000469339
    ENST00000490646 ENST00000475871 ENST00000545453(uc001viz.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DIS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DIS3 (see all 45):
    hsa-miR-548j hsa-miR-136 hsa-miR-4272 hsa-miR-200a hsa-miR-374a* hsa-miR-141 hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidDIS3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DIS3
    Predesigned siRNA for gene silencing in human, mouse, rat DIS3
    Clone
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    OriGene clones in human, mouse for DIS3 (see all 12)
    OriGene ORF clones in mouse, rat for DIS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DIS3 (NM_014953)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIS3
    Primer
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    OriGene qPCR primer pairs and template standards for DIS3
    OriGene qSTAR qPCR primer pairs in human, mouse for DIS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DIS3
      QuantiTect SYBR Green Assays in human, mouse, rat DIS3
      QuantiFast Probe-based Assays in human, mouse, rat DIS3

    Selected AceView cDNA sequences (see all 161):

    AA741205 AA768378 AA213647 AA258547 BC056143 AL832266 BX641208 BQ228050 
    AA300793 BQ932056 AW239246 D20392 BU430346 AI242310 BF767864 AA807584 
    AA236385 AW043622 AV728241 AA262938 BC012468 U79246 BM972526 BM760919 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DIS3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                                                              -     -           -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       
    SP5:                                                                    -                                                                                       

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for DIS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DIS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTTAATG
    DIS3 Expression
    About this image

    DIS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DIS3 Protein Expression

    UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1
    Tissue specificity: Widely expressed

        Custom PCR Arrays for DIS3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DIS3
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    QuantiTect SYBR Green Assays in human, mouse, rat DIS3
    QuantiFast Probe-based Assays in human, mouse, rat DIS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DIS3 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dis31 , 5 DIS3 mitotic control homolog (S. cerevisiae)1, 5 86.62(n)1
    91.46(a)1
      14 (49.25 cM)5
    726621  NM_028315.21  NP_082591.21 
     990766345 
    chicken
    (Gallus gallus)
    Aves DIS31 DIS3 mitotic control homolog (S. cerevisiae) 76.86(n)
    82.17(a)
      418821  XM_417016.3  XP_417016.3 
    lizard
    (Anolis carolinensis)
    Reptilia DIS36
    DIS3 mitotic control homolog (S. cerevisiae)
    75(a)
    1 ↔ 1
    3(88594053-88622530)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.326492 Xenopus laevis transcribed sequence with weak similarity more 77.78(n)    CA792887.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dis31 DIS3 mitotic control homolog (S. cerevisiae) 68.11(n)
    74.42(a)
      100003553  XM_001336814.5  XP_001336850.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dis31 , 3 3'-5' exoribonuclease3
    Dis31
    55(a)
    (best of 2)3
    55.92(n)1
    56.88(a)1
      429001  NM_001275981.11  NP_001262910.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C04G2.63
    dis-31
    S.pombe mitotic control protein like3
    dis-31
    45(a)
    (best of 2)3
    53.51(n)1
    47.26(a)1
      IV(10097383-10106546)3
    1778751  NM_069434.41  NP_501835.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIS3(YOL021C)4
    DIS31
    Exosome core complex catalytic subunit; possesses both more4
    DIS31
    53.57(n)1
    46.87(a)1
      15(285426-282421)4
    8541381, 4  NP_014621.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27631 EMB2763 54.08(n)
    50.61(a)
      816257  NM_001202612.1  NP_001189541.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01292001 Os03g0129200 54.13(n)
    50.58(a)
      4331494  NM_001055381.1  NP_001048846.1 


    ENSEMBL Gene Tree for DIS3 (if available)
    TreeFam Gene Tree for DIS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DIS3 gene
    DIS3L2  DIS3L22  
    2 SIMAP similar genes for DIS3 using alignment to 4 protein entries:     RRP44_HUMAN (see all proteins):
    DIS3L    FLJ00327

    DIS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DIS3 (see all 577)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1843907891,2
    --73330856(+) TAAGCA/GTCTGG 2 -- ut310--------
    rs1884971371,2
    --73330903(+) CCTGTA/GAAAAA 2 -- ut310--------
    rs65627281,2
    C,F,A,H--73330942(+) ATTGTA/GTAAGT 2 -- ut31 ese317Minor allele frequency- G:0.01NS EA NA WA CSA 796
    rs1485344341,2
    --73330944(+) TGTGTA/GAGTGT 2 -- ut310--------
    rs1405877751,2
    C--73331026(+) GGGTA-/TTTC  
            
    TTCGT
    2 -- ut310--------
    rs1931016871,2
    --73331082(+) TTAAAC/TGGAGA 2 -- ut310--------
    rs73291561,2
    C,F,H--73331166(+) gcacTA/GGAAAC 2 -- ut31 ese34Minor allele frequency- G:0.00NS EA 420
    rs1427910381,2
    C--73331202(+) ACTTAC/GGGGAA 2 -- ut310--------
    rs1476772451,2
    C--73331242(+) ACTCAA/GTTGGG 2 -- ut310--------
    rs775642541,2
    C--73331256(+) TATCCC/GTGAAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DIS3 (73329540 - 73356344 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DIS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2626867CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DIS3
    DNA2.0 Custom Variant and Variant Library Synthesis for DIS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607533    OMIM disorders: --

    4 diseases for DIS3:    About MalaCards
    nodular malignant melanoma    pneumonia    melanoma    malaria


    DIS3 for disorders           About GeneDecksing


    Export disorders for DIS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DIS3 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with DIS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. (PubMed id 11935316)1, 2, 3 Rozenblum E....Kallioniemi O.-P. (Hum. Genet. 2002)
    2. Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. (PubMed id 9562621)1, 2, 3 Shiomi T....Nishimoto T. (J. Biochem. 1998)
    3. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H.... Pruijn G.J. (EMBO J. 2010)
    4. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PubMed id 20531386)1, 2 Tomecki R.... Jensen T.H. (EMBO J. 2010)
    5. RNA exosome depletion reveals transcription upstream of active human promoters. (PubMed id 19056938)1, 2 Preker P.... Jensen T.H. (Science 2008)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22894 HGNC: 20604 AceView: KIAA1008 Ensembl:ENSG00000083520 euGenes: HUgn22894
    ECgene: DIS3 Kegg: 22894 H-InvDB: DIS3

    (According to HUGE)
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    HUGE: KIAA1008

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DIS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DIS3 gene:
    Search GeneIP for patents involving DIS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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