Aliases for DIS3 Gene
- DIS3 Exosome Endoribonuclease And 3'-5' Exoribonuclease 2
- KIAA1008 2 3 4 6
- DIS3 Exosome Endoribonuclease And 3-5 Exoribonuclease 2 3
- Ribosomal RNA-Processing Protein 44 3 4
- Exosome Component 11 2 3
- RRP44 3 4
- DIS3 Mitotic Control Homolog (S. Cerevisiae) 2
- Mitotic Control Protein Dis3 Homolog 3
- Exosome Complex Exonuclease RRP44 3
External Ids for DIS3 Gene
Previous Symbols for DIS3 Gene
GeneCards Summary for DIS3 Gene
DIS3 (DIS3 Exosome Endoribonuclease And 3'-5' Exoribonuclease) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include RNA binding and endonuclease activity. An important paralog of this gene is DIS3L.
UniProtKB/Swiss-Prot for DIS3 Gene
Putative catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3-5 exonuclease and endonuclease activities.