DIS3 Gene
protein-coding GIFtS: 62
GCID: GC13M073329
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|
DIS3 mitotic control homolog (S. cerevisiae)(Previous name: KIAA1008 )
(Previous symbol: KIAA1008)
| |
Aliases
for DIS3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DIS3 Mitotic Control Homolog (S. Cerevisiae)1 2 | | RP11-342J4.32 | | KIAA10081 2 3 5 | | BA555G22.11 | | RRP441 2 3 | | Exosome Complex Exonuclease RRP442 | | EXOSC111 2 | | Exosome Component 112 | | Dis3p1 | | Mitotic Control Protein Dis3 Homolog2 | | Protein DIS3 Homolog2 3 | | EC 3.1.13.-3 | | Ribosomal RNA-Processing Protein 442 3 | | EC 3.1.26.-3 | | 2810028N01Rik2 | | EC 3.1.138 |
Export aliases for DIS3 gene to outside databasesPrevious GC identifers: GC13M071296 GC13M067324 GC13M072266 GC13M071127 GC13M054026 |
Summaries
for DIS3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity andparticipates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complexis involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNAprocessing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstreamtranscripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to thecytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNAexosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containingAU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translationof aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease andendonuclease activities
Gene Wiki entry for DIS3
|
Genomic Views
for DIS3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DIS3 gene promoter:
AhR Pax-5 GATA-3 p53 Brachyury C/EBPalpha Arnt GATA-2 N-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for DIS3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIS3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q22.1 Ensembl cytogenetic band: 13q22.1 HGNC cytogenetic band: 13q21.32DIS3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M073329: view genomic region
(about GC identifiers)
Start:
|
73,329,540 bp from pter |
End:
|
73,356,344 bp from pter |
Size:
|
26,805 bases |
Orientation:
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minus strand |
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Proteins
for DIS3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1 (See
protein sequence)Recommended Name: Exosome complex exonuclease RRP44 Size: 958 amino acids; 109003 Da
Cofactor: Magnesium and manganese
Subunit: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believedto associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosomecomplex forms
Subcellular location: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in thenucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded fromnucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3
Miscellaneous: The association of DIS3 with the RNA exosome complex appears to be weak explaining its absence in somecomplex purifications
Sequence caution: Sequence=BAA76852.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NI21 B2RBL2 Q5W0P7 Q5W0P8 Q658Z7 Q7Z481 Q8WWI2 Q9UG36Alternative splicing: 2 isoforms: Q9Y2L1-1 Q9Y2L1-2 Explore the universe of human proteins at neXtProt for DIS3: NX_Q9Y2L1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2L1
4/8 DME Specific Peptides for DIS3 (Q9Y2L1) (see all 8)
DIS3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001121698.1 NP_055768.3
ENSEMBL proteins: ENSP00000366997 ENSP00000367011 ENSP00000436350 ENSP00000440058 Reactome Protein details: Q9Y2L1
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DIS3 for ontologies About GeneDecksing
DIS3 Antibody Products:
Assay Products for DIS3: |
Protein
Domains /
Families
for DIS3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DIS3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2L1ProtoNet protein and cluster: Q9Y2L1 2 Blocks protein families: IPB001900 Ribonuclease II IPB006596 Nucleotide binding protein
UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1Similarity: Belongs to the RNR ribonuclease familySimilarity: Contains 1 PINc domain |
Function
for DIS3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1Function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity andparticipates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complexis involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNAprocessing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstreamtranscripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to thecytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNAexosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containingAU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translationof aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease andendonuclease activitiesEnzyme Numbers (IUBMB): EC 3.1.13.-1 EC 3.1.132 EC 3.1.26.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIS3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIS3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DIS3 (NM_014953) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DIS3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIS3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
DIS3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DIS3:
|
Pathways & Interactions
for DIS3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Destabilization of mRNA by Tristetraprolin (TTP) | | | 2 | Deadenylation-dependent mRNA decay | | | 3 | Metabolism of mRNA | | | 4 | ATP/ITP metabolism | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DIS3
1  GeneGo (Thomson Reuters) Pathway for DIS3
5/9 
Reactome Pathways for DIS3 (see all 9)
1 
Kegg Pathway (Kegg details for DIS3):
DIS3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DIS3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/125 Interacting proteins for DIS3 (Q9Y2L11, 2, 3 ENSP000003669974) via UniProtKB, MINT, STRING, and/or I2D (see all 125)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
DIS3 for ontologies About GeneDecksing
|
Drugs & Compounds
for DIS3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DIS3
Search CenterWatch for drugs/clinical trials and news about DIS3 / RRP44
|
Transcripts
for DIS3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DIS3 gene (2 alternative transcripts): NM_001128226.1 NM_014953.3 Unigene Cluster for DIS3: DIS3 mitotic control homolog (S. cerevisiae) Hs.744104 [show with all ESTs]Unigene Representative Sequence: NM_0149536 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377767(uc001viy.4 uc001vix.4) ENST00000377780 ENST00000469339
ENST00000490646 ENST00000475871 ENST00000545453(uc001viz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIS3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIS3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DIS3 (NM_014953) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DIS3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIS3 |
Additional cDNA sequence: AB001743.1 AB023225.1 AF035310.1 AF330044.1 AK001346.1 AK025634.1 AK314715.1 AL080158.1 AL832266.1 BC012468.1 BC038101.1 BC056143.1 U79246.1 14 DOTS entries: DT.112004 DT.95123236 DT.112184 DT.91711187 DT.99938385 DT.120765121 DT.100776569 DT.444967 DT.120765176 DT.95233450 DT.120765017 DT.75139840 DT.100793167 DT.101975445 24/161 AceView cDNA sequences (see all 161): BQ228050 AL080158 AA258547 BQ932056 AA213647 AV728241 BU430346 BC056143 D20392 AA741205 BM453322 AW239246 U79246 BM972526 AA262938 BM760919 AA236385 BC012468 R15846 BP370472 AA807584 AI242310 BM463271 AW043622
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DIS3 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | | |
| SP4: | | | | | | | | | | | |
| SP5: | | | | | | | | | | |
ECgene alternative splicing isoforms for DIS3
|
Expression
for DIS3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DIS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTTAATG
About this image
See DIS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DIS3
SOURCE GeneReport for Unigene cluster: Hs.744104
UniProtKB/Swiss-Prot: RRP44_HUMAN, Q9Y2L1Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for DIS3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIS3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DIS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIS3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3 |
Orthologs
for DIS3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for DIS3 gene from 10/36 species (see all 36) About this table
ENSEMBL Gene Tree for DIS3 (if available)
TreeFam Gene Tree for DIS3 (if available) |
Paralogs
for DIS3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DIS3 gene
- DIS3L2 DIS3L22
3 SIMAP similar genes for DIS3 using alignment to 4 protein entries: RRP44_HUMAN (see all proteins):DIS3L FLJ00327 DIS3L2
DIS3 for paralogs About GeneDecksing
|
Genomic Variants
for DIS3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DIS3 (73329540 - 73356344 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DIS3
1 CNV: 101775 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIS3 |
|
Disorders
/ Diseases
for DIS3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DIS3 for disorders About GeneDecksing
OMIM gene information: 607533
OMIM disorders: --
5  diseases for DIS3: About MalaCardsnodular malignant melanoma pneumonia melanoma malaria
carcinoma
Export disorders for DIS3 gene to outside databases
|
Publications
for DIS3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DIS3 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with DIS3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. (PubMed id 11935316)1, 2, 3 Rozenblum E....Kallioniemi O.-P. (2002)
- Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3. (PubMed id 9562621)1, 2, 3 Shiomi T....Nishimoto T. (1998)
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PubMed id 20531389)1, 2 Staals R.H....Pruijn G.J. (2010)
- The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. (PubMed id 20531386)1, 2 Tomecki R....Jensen T.H. (2010)
- RNA exosome depletion reveals transcription upstream of active human promoters. (PubMed id 19056938)1, 2 Preker P.... Jensen T.H. (2008)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
|
External Searches for DIS3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DIS3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DIS3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DIS3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DIS3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DIS3 gene:
Search GeneIP for patents involving DIS3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DIS3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DIS3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DIS3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIS3 | | | OriGene Protein Over-expression Lysate for DIS3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DIS3 | | OriGene 3'-UTR Clone for DIS3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIS3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIS3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DIS3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DIS3 | | OriGene Custom Protein Services for DIS3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DIS3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIS3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIS3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DIS3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIS3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIS3 |
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| | | | Search Tocris compounds for DIS3 |
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 | | | DIS3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIS3 |
|  |  |  | | | | ThermoFisher Antibodies for DIS3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIS3 |
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