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Aliases for DIRC3 Gene

Subcategory (RNA class) for DIRC3 Gene


Quality Score for this RNA gene is


Aliases for DIRC3 Gene

  • Disrupted In Renal Carcinoma 3 2 3

External Ids for DIRC3 Gene

ORGUL Members for DIRC3 Gene

Previous GeneCards Identifiers for DIRC3 Gene

  • GC00U912756
  • GC02U900716
  • GC02M218174
  • GC02M218276
  • GC02M210003

Summaries for DIRC3 Gene

GeneCards Summary for DIRC3 Gene

DIRC3 (Disrupted In Renal Carcinoma 3) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DIRC3 include thyroid carcinoma, papillary.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIRC3 Gene

Genomics for DIRC3 Gene

Regulatory Elements for DIRC3 Gene

Genomic Location for DIRC3 Gene

217,284,019 bp from pter
217,756,593 bp from pter
472,575 bases
Minus strand

Genomic View for DIRC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIRC3 Gene

Proteins for DIRC3 Gene

  • Protein details for DIRC3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein DIRC3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DIRC3 Gene

    131 amino acids
    Molecular mass:
    14375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DIRC3 Gene

Proteomics data for DIRC3 Gene at MOPED

Post-translational modifications for DIRC3 Gene

No Post-translational modifications

Other Protein References for DIRC3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for DIRC3 Gene

Domains for DIRC3 Gene

Protein Domains for DIRC3 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DIRC3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DIRC3 Gene

Function for DIRC3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DIRC3 Gene

Localization for DIRC3 Gene

Subcellular locations from

Jensen Localization Image for DIRC3 Gene COMPARTMENTS Subcellular localization image for DIRC3 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DIRC3 Gene

Pathways for DIRC3 Gene

SuperPathways for DIRC3 Gene

No Data Available

Interacting Proteins for DIRC3 Gene

Gene Ontology (GO) - Biological Process for DIRC3 Gene


No data available for Pathways by source for DIRC3 Gene

Transcripts for DIRC3 Gene

mRNA/cDNA for DIRC3 Gene

(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DIRC3 Gene

Disrupted in renal carcinoma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIRC3 Gene

No ASD Table

Relevant External Links for DIRC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIRC3 Gene

mRNA expression in normal human tissues for DIRC3 Gene

SOURCE GeneReport for Unigene cluster for DIRC3 Gene Hs.572788

genes like me logo Genes that share expressions with DIRC3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for DIRC3 Gene

Orthologs for DIRC3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DIRC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIRC3 36
  • 98 (a)
Species with no ortholog for DIRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DIRC3 Gene

Gene Tree for DIRC3 (if available)
Gene Tree for DIRC3 (if available)

Paralogs for DIRC3 Gene

No data available for Paralogs for DIRC3 Gene

Variants for DIRC3 Gene

Sequence variations from dbSNP and Humsavar for DIRC3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2152 -- 217,757,393(-) aagcc(C/T)gtaca upstream-variant-2KB
rs12927 -- 217,284,160(-) TGAAT(A/G)AACAA nc-transcript-variant
rs714862 -- 217,374,703(-) CAAAC(C/T)AATAA intron-variant
rs718685 -- 217,521,361(-) TCATG(A/T)TGGCC intron-variant
rs718686 -- 217,521,229(-) AAAAT(C/T)TACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIRC3 Gene

Variant ID Type Subtype PubMed ID
nsv834539 CNV Gain 17160897
esv270694 CNV Insertion 20981092
esv274558 CNV Insertion 20981092
esv1580867 CNV Insertion 17803354
esv274296 CNV Insertion 20981092
nsv460101 CNV Loss 19166990
esv2721466 CNV Deletion 23290073
nsv508129 CNV Loss 20534489
esv2668873 CNV Deletion 23128226
esv2661099 CNV Deletion 23128226
esv269834 CNV Insertion 20981092
esv273846 CNV Insertion 20981092
esv2450238 CNV Deletion 19546169
esv2721467 CNV Deletion 23290073
esv2721468 CNV Deletion 23290073
nsv523924 CNV Loss 19592680
esv2721469 CNV Deletion 23290073
nsv834540 CNV Gain 17160897
nsv527935 CNV Loss 19592680
esv1156929 CNV Insertion 17803354
esv2721470 CNV Deletion 23290073
esv993506 CNV Deletion 20482838

Relevant External Links for DIRC3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIRC3 Gene

Disorders for DIRC3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DIRC3 Gene in MalaCards »

(1) Disease for DIRC3 Gene

Relevant External Links for DIRC3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with DIRC3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DIRC3 Gene

Publications for DIRC3 Gene

  1. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 48
  2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 48
  3. Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21). (PMID: 12939738) Bodmer D. … Geurts van Kessel A. (Genes Chromosomes Cancer 2003) 2 3
  4. Discovery of common variants associated with low TSH levels and thyroid cancer risk. (PMID: 22267200) Gudmundsson J. … Stefansson K. (Nat. Genet. 2012) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for DIRC3 Gene

Sources for DIRC3 Gene

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