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Aliases for DIRC3 Gene

Subcategory (RNA class) for DIRC3 Gene


Quality Score for this RNA gene is


Aliases for DIRC3 Gene

  • Disrupted In Renal Carcinoma 3 2 3 5

External Ids for DIRC3 Gene

Previous GeneCards Identifiers for DIRC3 Gene

  • GC00U912756
  • GC02U900716
  • GC02M218174
  • GC02M218276
  • GC02M210003

Summaries for DIRC3 Gene

GeneCards Summary for DIRC3 Gene

DIRC3 (Disrupted In Renal Carcinoma 3) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with DIRC3 include Hereditary Clear Cell Renal Cell Carcinoma and Differentiated Thyroid Carcinoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIRC3 Gene

Genomics for DIRC3 Gene

Regulatory Elements for DIRC3 Gene

Enhancers for DIRC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIRC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DIRC3 Gene

217,284,019 bp from pter
217,756,593 bp from pter
472,575 bases
Minus strand

Genomic View for DIRC3 Gene

Genes around DIRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIRC3 Gene

Proteins for DIRC3 Gene

  • Protein details for DIRC3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein DIRC3
    Protein Accession:

    Protein attributes for DIRC3 Gene

    131 amino acids
    Molecular mass:
    14375 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DIRC3 Gene

Proteomics data for DIRC3 Gene at MOPED

Post-translational modifications for DIRC3 Gene

No Post-translational modifications

Other Protein References for DIRC3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for DIRC3 Gene

Domains & Families for DIRC3 Gene

Protein Domains for DIRC3 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DIRC3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DIRC3 Gene

Function for DIRC3 Gene

Phenotypes for DIRC3 Gene

GenomeRNAi human phenotypes for DIRC3:
genes like me logo Genes that share phenotypes with DIRC3: view

Human Phenotype Ontology for DIRC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DIRC3 Gene

Localization for DIRC3 Gene

Subcellular locations from

Jensen Localization Image for DIRC3 Gene COMPARTMENTS Subcellular localization image for DIRC3 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DIRC3 Gene

Pathways & Interactions for DIRC3 Gene

SuperPathways for DIRC3 Gene

No Data Available

Interacting Proteins for DIRC3 Gene

Gene Ontology (GO) - Biological Process for DIRC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for DIRC3 Gene

Drugs & Compounds for DIRC3 Gene

No Compound Related Data Available

Transcripts for DIRC3 Gene

mRNA/cDNA for DIRC3 Gene

(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DIRC3 Gene

Disrupted in renal carcinoma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIRC3 Gene

No ASD Table

Relevant External Links for DIRC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIRC3 Gene

mRNA expression in normal human tissues for DIRC3 Gene

SOURCE GeneReport for Unigene cluster for DIRC3 Gene Hs.572788

genes like me logo Genes that share expression patterns with DIRC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DIRC3 Gene

Orthologs for DIRC3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DIRC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIRC3 36
  • 98 (a)
Species with no ortholog for DIRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DIRC3 Gene

Gene Tree for DIRC3 (if available)
Gene Tree for DIRC3 (if available)

Paralogs for DIRC3 Gene

No data available for Paralogs for DIRC3 Gene

Variants for DIRC3 Gene

Sequence variations from dbSNP and Humsavar for DIRC3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs714862 -- 217,374,703(-) CAAAC(C/T)AATAA intron-variant
rs718685 -- 217,521,361(-) TCATG(A/T)TGGCC intron-variant
rs718686 -- 217,521,229(-) AAAAT(C/T)TACCA intron-variant
rs722082 -- 217,374,516(-) ATTTA(C/T)GAGTT intron-variant
rs727510 -- 217,711,125(+) ACCTA(A/G)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIRC3 Gene

Variant ID Type Subtype PubMed ID
nsv834539 CNV Gain 17160897
esv270694 CNV Insertion 20981092
esv274558 CNV Insertion 20981092
esv1580867 CNV Insertion 17803354
esv274296 CNV Insertion 20981092
nsv460101 CNV Loss 19166990
esv2721466 CNV Deletion 23290073
nsv508129 CNV Loss 20534489
esv2668873 CNV Deletion 23128226
esv2661099 CNV Deletion 23128226
esv269834 CNV Insertion 20981092
esv273846 CNV Insertion 20981092
esv2450238 CNV Deletion 19546169
esv2721467 CNV Deletion 23290073
esv2721468 CNV Deletion 23290073
nsv523924 CNV Loss 19592680
esv2721469 CNV Deletion 23290073
nsv834540 CNV Gain 17160897
nsv527935 CNV Loss 19592680
esv1156929 CNV Insertion 17803354
esv2721470 CNV Deletion 23290073
esv993506 CNV Deletion 20482838

Variation tolerance for DIRC3 Gene

Gene Damage Index Score: 6.30; 76.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIRC3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIRC3 Gene

Disorders for DIRC3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DIRC3 Gene - From: Orphanet

Disorder Aliases PubMed IDs
hereditary clear cell renal cell carcinoma
  • hereditary clear cell renal cell adenocarcinoma
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search DIRC3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIRC3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DIRC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIRC3 Gene

Publications for DIRC3 Gene

  1. Discovery of common variants associated with low TSH levels and thyroid cancer risk. (PMID: 22267200) Gudmundsson J. … Stefansson K. (Nat. Genet. 2012) 3 48 67
  2. Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21). (PMID: 12939738) Bodmer D. … Geurts van Kessel A. (Genes Chromosomes Cancer 2003) 2 3
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx J.J. … Ophoff R.A. (Mol. Psychiatry 2013) 3
  5. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3

Products for DIRC3 Gene

Sources for DIRC3 Gene