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DIRC2 Gene

protein-coding   GIFtS: 47
GCID: GC03P122513

Disrupted In Renal Carcinoma 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Disrupted In Renal Carcinoma 21 2
Disrupted In Renal Cancer Protein 21 2 3
Renal Cell Carcinoma 41 2
RCC42 5
Disrupted In Renal Carcinoma Protein 22

External Ids:    HGNC: 166281   Entrez Gene: 849252   Ensembl: ENSG000001384637   OMIM: 6027735   UniProtKB: Q96SL13   

Export aliases for DIRC2 gene to outside databases

Previous GC identifers: GC03P119232 GC03P122462 GC03P123794 GC03P123835 GC03P123836 GC03P123996 GC03P119887


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DIRC2 Gene:
This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of
this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively
spliced transcript variants have been described, but their biological validity has not yet been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DIRC2 Gene:
DIRC2 (disrupted in renal carcinoma 2) is a protein-coding gene. Diseases associated with DIRC2 include renal cell carcinoma 4, and renal cell carcinoma. An important paralog of this gene is MFSD7.

UniProtKB/Swiss-Prot: DIRC2_HUMAN, Q96SL1
Function: Electrogenic metabolite transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DIRC2 gene promoter:
         p53   E4BP4   POU3F2   c-Ets-1   Evi-1   AREB6   HEN1   CHOP-10   FAC1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDIRC2 promoter sequence
   Search Chromatin IP Primers for DIRC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DIRC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21.1

DIRC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIRC2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P122513:  view genomic region     (about GC identifiers)

Start:
122,513,642 bp from pter      End:
122,599,986 bp from pter
Size:
86,345 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DIRC2_HUMAN, Q96SL1 (See protein sequence)
Recommended Name: Disrupted in renal carcinoma protein 2  
Size: 478 amino acids; 52088 Da
Secondary accessions: A8K561 Q8NBX9
Alternative splicing: 2 isoforms:  Q96SL1-1   Q96SL1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DIRC2: NX_Q96SL1

Explore proteomics data for DIRC2 at MOPED

Post-translational modifications: 

  • Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated N-terminal and a
    non-glycosylated C-terminal fragment1
  • Glycosylation2 at Asn209

  • See DIRC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116228.1  
    ENSEMBL proteins: 
     ENSP00000261038   ENSP00000418554  

    DIRC2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DIRC2

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    LSBio Antibodies in human, mouse, rat for DIRC2

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    Cloud-Clone Corp. CLIAs for DIRC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Disrupted in renal carcinoma 2
    SLC49 family of FLVCR-related haem transporters

    1 InterPro protein domain:
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q96SL1

    ProtoNet protein and cluster: Q96SL1

    UniProtKB/Swiss-Prot: DIRC2_HUMAN, Q96SL1
    Similarity: Belongs to the major facilitator superfamily


    DIRC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DIRC2_HUMAN, Q96SL1
    Function: Electrogenic metabolite transporter

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DIRC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DIRC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DIRC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DIRC2:
    hsa-mir-320a (MIRT044387)

    Block miRNA regulation of human, mouse, rat DIRC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DIRC2 (see all 50):
    hsa-miR-26a-2* hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-372 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidDIRC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DIRC2
    Predesigned siRNA for gene silencing in human, mouse, rat DIRC2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DIRC2 (NM_032839)
    Sino Biological Human cDNA Clone for DIRC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIRC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIRC2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DIRC2_HUMAN, Q96SL1: Lysosome membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral component of membrane IEA--

    DIRC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DIRC2
    Interactions:

        Search GeneGlobe Interaction Network for DIRC2

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    DIRC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DIRC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DIRC2 gene: 
    NM_032839.2  

    Unigene Cluster for DIRC2:

    Disrupted in renal carcinoma 2
    Hs.477346  [show with all ESTs]
    Unigene Representative Sequence: NM_032839
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261038(uc003efw.4 uc010hrl.3 uc010hrm.3) ENST00000477647

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DIRC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DIRC2 (see all 50):
    hsa-miR-26a-2* hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-372 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidDIRC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DIRC2
    Predesigned siRNA for gene silencing in human, mouse, rat DIRC2
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    OriGene ORF clones in mouse, rat for DIRC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DIRC2 (NM_032839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIRC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIRC2
    Primer
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    OriGene qPCR primer pairs and template standards for DIRC2
    OriGene qSTAR qPCR primer pairs in human, mouse for DIRC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DIRC2
      QuantiTect SYBR Green Assays in human, mouse, rat DIRC2
      QuantiFast Probe-based Assays in human, mouse, rat DIRC2

    Additional mRNA sequence: 

    AK027690.1 AK075158.1 AK291176.1 BC022204.1 BC033738.1 BC039821.1 

    5 DOTS entries:

    DT.113781  DT.211595  DT.100784942  DT.91727901  DT.100784943 

    Selected AceView cDNA sequences (see all 120):

    AA371469 Z39752 R49386 AW592488 BF593262 Z43693 N29859 BU075645 
    AA031273 NM_032839 BM787946 AA234945 BP352670 BX106061 CD743084 AA234944 
    BM804078 AK027690 AA031274 BC039821 AK075158 BC033738 AI129738 BQ380052 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DIRC2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                      
    SP2:                                            -         


    ECgene alternative splicing isoforms for DIRC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DIRC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACACTACAT
    DIRC2 Expression
    About this image

    DIRC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DIRC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477346

    UniProtKB/Swiss-Prot: DIRC2_HUMAN, Q96SL1
    Tissue specificity: Ubiquitous. Expressed in proximal tubular cells of the kidney

        Custom PCR Arrays for DIRC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DIRC2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dirc21 , 5 disrupted in renal carcinoma 2 (human)1, 5 87.7(n)1
    94.55(a)1
      16 (25.43 cM)5
    2241321  NM_153550.31  NP_705778.11 
     356940625 
    chicken
    (Gallus gallus)
    Aves DIRC21 disrupted in renal carcinoma 2 79.31(n)
    87.19(a)
      424246  XM_422095.4  XP_422095.4 
    lizard
    (Anolis carolinensis)
    Reptilia DIRC26
    disrupted in renal carcinoma 2
    80(a)
    1 ↔ 1
    1(83300284-83398104)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135462 Xenopus laevis transcribed sequence with moderate similarity more 76.23(n)    BJ033200.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.127862 Transcribed sequence with weak similarity to protein more 73.8(n)    CK142593.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C27A7.66
    Protein C27A7.6, isoform c (C27A7.6) mRNA, complet...
    19(a)
    many ↔ many
    V(12124848-12130788) WBGene00007757


    ENSEMBL Gene Tree for DIRC2 (if available)
    TreeFam Gene Tree for DIRC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DIRC2 gene
    MFSD72  FLVCR12  FLVCR22  

    DIRC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DIRC2 (see all 1510)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008378071,2
    C--119889390(+) CTGCT-/AAAAAA 1 -- int10--------
    rs58523151,2
    C--119897734(+) GAGAG-/AGAGAG 1 -- int1 trp31Minor allele frequency- A:0.50CSA 2
    rs359056001,2
    C--119897736(+) AGAGG-/AAGAGA 1 -- int10--------
    rs1460806661,2
    C--119900284(+) TTAGG-/TCAT  
            
    TCATT
    1 -- int10--------
    rs2015552471,2
    --119929550(+) ACTAC-/AAGGCT 1 -- int10--------
    rs114497121,2
    C--119935512(+) ACCCCT/-ATAAG 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs671279661,2
    C--119935514(+) CCCCA-/TTAAGT 1 -- int10--------
    rs724370081,2
    C--119937104(+) GAAGA-/ATATATA 1 -- int10--------
    rs58523161,2
    C--119961459(+) CCCCCC/-AGTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs106371451,2
    C--119962240(+) GTGTG-/CT    
       T
    /TTC
    TTATT
    2 -- cds10--------

    HapMap Linkage Disequilibrium report for DIRC2 (122513642 - 122599986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DIRC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2590652CNV Deletion19546169
    nsv877392CNV Loss21882294
    nsv877391CNV Gain21882294
    nsv829706CNV Gain17160897
    nsv517377CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): DIRC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DIRC2
    DNA2.0 Custom Variant and Variant Library Synthesis for DIRC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602773   
    OMIM disorders: 144700  
    UniProtKB/Swiss-Prot: DIRC2_HUMAN, Q96SL1
  • Note=A chromosomal aberration involving DIRC2 has been found in a family with renal carcinoma.
    Translocation t(2;3)(q35;q21)

  • 8 diseases for DIRC2:    About MalaCards
    renal cell carcinoma 4    renal cell carcinoma    familial renal cell carcinoma    seminal vesicle tumor
    kidney cancer    hemangioblastoma    multiple myeloma    myeloma

    2 diseases from the University of Copenhagen DISEASES database for DIRC2:
    Renal cell carcinoma     Seminal vesicle tumor

    DIRC2 for disorders           About GeneDecksing


    Export disorders for DIRC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DIRC2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DIRC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21). (PubMed id 11912179)1, 2, 3 Bodmer D....van Kessel A.G. (Hum. Mol. Genet. 2002)
    2. Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L. (PubMed id 21692750)1, 2 Savalas L.R....Schroder B. (Biochem. J. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. Molecular cytogenetic analysis of clustered sporadic and familial renal cell carcinoma-associated 3q13 approximately q22 breakpoints. (PubMed id 12237231)1 Bodmer D....van Kessel A.G. (Cancer Genet. Cytogenet. 2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84925 HGNC: 16628 AceView: DIRC2 Ensembl:ENSG00000138463 euGenes: HUgn84925
    ECgene: DIRC2 H-InvDB: DIRC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DIRC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DIRC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DIRC2 gene:
    Search GeneIP for patents involving DIRC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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