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DIRAS3 Gene

protein-coding   GIFtS: 47
GCID: GC01M068511

DIRAS Family, GTP-Binding RAS-Like 3

(Previous names: ras homolog gene family, member I)
(Previous symbol: ARHI)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DIRAS Family, GTP-Binding RAS-Like 31 2     Rho-Related GTP-Binding Protein RhoI2 3
ARHI1 2 3 5     NOEY22 3
Ras Homolog Gene Family, Member I1 2     GTP-Binding Protein Di-Ras32
Distinct Subgroup Of The Ras Family Member 32 3     RHOI3

External Ids:    HGNC: 6871   Entrez Gene: 90772   Ensembl: ENSG000001625957   OMIM: 6051935   UniProtKB: O956613   

Export aliases for DIRAS3 gene to outside databases

Previous GC identifers: GC01M068224 GC01M068284 GC01M066622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DIRAS3 Gene:
This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but
not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele,
which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose
function is abrogated in ovarian and breast cancers. (provided by RefSeq, Oct 2010)

GeneCards Summary for DIRAS3 Gene:
DIRAS3 (DIRAS family, GTP-binding RAS-like 3) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DIRAS3 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DIRAS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DIRAS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31

DIRAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIRAS3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M068511:  view genomic region     (about GC identifiers)

Start:
68,511,645 bp from pter      End:
68,517,314 bp from pter
Size:
5,670 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DIRA3_HUMAN, O95661 (See protein sequence)
Recommended Name: GTP-binding protein Di-Ras3 precursor  
Size: 229 amino acids; 25861 Da
Secondary accessions: B3KMP3

Explore the universe of human proteins at neXtProt for DIRAS3: NX_O95661

Explore proteomics data for DIRAS3 at MOPED


See DIRAS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004666.1  
ENSEMBL proteins: 
 ENSP00000360020   ENSP00000378627  

DIRAS3 Human Recombinant Protein Products:

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Novus Biologicals DIRAS3 Lysate
Sino Biological Recombinant Protein for DIRAS3
Sino Biological Cell Lysate for DIRAS3
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Browse Proteins at Cloud-Clone Corp.

 
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antibodies-online proteins for DIRAS3 (4 products) 

 
Search antibodies-online for peptides for DIRAS3

DIRAS3 Antibody Products:

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Abcam antibodies for DIRAS3
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ThermoFisher Antibody for DIRAS3
antibodies-online antibodies for DIRAS3 (27 products) 

DIRAS3 Assay Products:

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Search eBioscience for ELISAs for DIRAS3 
antibodies-online kits for DIRAS3 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR027417 P-loop_NTPase
 IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry O95661

ProtoNet protein and cluster: O95661

UniProtKB/Swiss-Prot: DIRA3_HUMAN, O95661
Similarity: Belongs to the small GTPase superfamily. Di-Ras family


Find genes that share domains with DIRAS3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity TAS9874798
GO:0005515protein binding IPI--
GO:0005525GTP binding IEA--
     
Find genes that share ontologies with DIRAS3           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DIRAS3

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat DIRAS3 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate DIRAS3:
hsa-miR-579
SwitchGear 3'UTR luciferase reporter plasmidDIRAS3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DIRAS3
Predesigned siRNA for gene silencing in human, mouse, rat DIRAS3

Gene Editing
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DNA2.0 Custom Protein Engineering Service for DIRAS3

Clone
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OriGene clones in human, mouse for DIRAS3 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DIRAS3 (NM_004675)
Sino Biological Human cDNA Clone for DIRAS3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIRAS3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIRAS3

Cell Line
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GenScript Custom overexpressing Cell Line Services for DIRAS3
Browse ESI BIO Cell Lines and PureStem Progenitors for DIRAS3 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRAS3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DIRA3_HUMAN, O95661: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
cytosol2
mitochondrion2
extracellular1
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005886plasma membrane IEA--
GO:0016020membrane ----

Find genes that share ontologies with DIRAS3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DIRAS3 (see all 33)
    Fc-GammaR Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Tec Kinases Signaling
Crosstalk Between CARM1 and ESRs



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DIRAS3
Interactions:

    Search GeneGlobe Interaction Network for DIRAS3

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for DIRAS3 (O956611 ENSP000003600204) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
STAT3P407631, ENSP000002646574EBI-6139214,EBI-518675 STRING: ENSP00000264657
PRAMEF3ENSP000003653434STRING: ENSP00000365343
RAC1ENSP000003484614STRING: ENSP00000348461
RAC2ENSP000002490714STRING: ENSP00000249071
RAC3ENSP000003042834STRING: ENSP00000304283
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS9874798
GO:0006184GTP catabolic process ----
GO:0006349regulation of gene expression by genetic imprinting TAS9874798
GO:0007165signal transduction ----
GO:0007264small GTPase mediated signal transduction IEA--

Find genes that share ontologies with DIRAS3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DIRAS3 (DIRA3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DIRAS3 gene: 
NM_004675.2  

Unigene Cluster for DIRAS3:

DIRAS family, GTP-binding RAS-like 3
Hs.194695  [show with all ESTs]
Unigene Representative Sequence: AK096393
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370981(uc001ded.3) ENST00000395201
miRNA
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Block miRNA regulation of human, mouse, rat DIRAS3 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate DIRAS3:
hsa-miR-579
SwitchGear 3'UTR luciferase reporter plasmidDIRAS3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DIRAS3
Predesigned siRNA for gene silencing in human, mouse, rat DIRAS3
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GenScript: all cDNA clones in your preferred vector: DIRAS3 (NM_004675)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIRAS3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIRAS3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DIRAS3
OriGene qSTAR qPCR primer pairs in human, mouse for DIRAS3
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DIRAS3
  QuantiTect SYBR Green Assays in human, mouse, rat DIRAS3
  QuantiFast Probe-based Assays in human, mouse, rat DIRAS3

Additional mRNA sequence: 

AK021882.1 AK096393.1 BC005362.1 CR541870.1 CR541892.1 U96750.1 

3 DOTS entries:

DT.105317  DT.100746681  DT.91749219 

Selected AceView cDNA sequences (see all 31):

BX114681 AA878446 NM_004675 U96750 CD237061 BM544956 BI599064 BI668300 
BG707443 AL037802 BI603847 BG541618 T17198 AK096393 CD513232 BC005362 
AI692753 BF967422 AV754822 BF967643 BG708862 AL037822 AI215023 BI668243 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DIRAS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGAAAAAAA
DIRAS3 Expression
About this image


DIRAS3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Ovary (Reproductive System)
         Oviduct
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Fibroblasts
         Detroit 551
 
 Epidermis (Integumentary System)
         Detroit 551
 
 Brain (Nervous System)
         Hypothalamus
DIRAS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DIRAS3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.194695

UniProtKB/Swiss-Prot: DIRA3_HUMAN, O95661
Tissue specificity: Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers

    Custom PCR Arrays for DIRAS3
Primer
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QuantiFast Probe-based Assays in human, mouse, rat DIRAS3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRAS3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DIRAS3 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
Uncharacterized protein
27(a)
many ↔ many
6(120283792-120284451)
chicken
(Gallus gallus)
Aves RAP2B6
Gallus gallus RAP2B, member of RAS oncogene family...
27(a)
many ↔ many
18(4042902-4043528)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
51(a)
many ↔ many
GL343328.1(274449-275045)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-27j5.56
si:dkey-27j5.5
15(a)
many ↔ many
1(57737785-57740425) ENSDARG00000026383
fruit fly
(Drosophila melanogaster)
Insecta CG85006
--
39(a)
1 → many
3R(5610408-5615059)
worm
(Caenorhabditis elegans)
Secernentea drn-16
Protein DRN-1 (drn-1) mRNA, complete cds
41(a)
1 → many
II(5270366-5271824) WBGene00016911


ENSEMBL Gene Tree for DIRAS3 (if available)
TreeFam Gene Tree for DIRAS3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DIRAS3 gene
RAP2C2  RASL10B2  DIRAS12  RAP1B2  RASD22  RIT22  RAP2A2  RIT12  
RAP1A2  RAP2B2  RASD12  DIRAS22  RASL10A2  
17 SIMAP similar genes for DIRAS3 using alignment to 1 protein entry:     DIRA3_HUMAN:
DIRAS1    DIRAS2    DKFZp547A0616    RAP2A    RAP2B    RAP1A
RAP2C    RAP1B    RASD2    RALB    RHEBL1    RIT1
RRAS    NRAS    RIT2    MRAS    RRAS2

Find genes that share paralogs with DIRAS3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DIRAS3 (see all 191)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2002709931,2
C--68582965(+) CCCAAA/TTTAAA 1 -- ds50010--------
rs2003395001,2
C--68582968(+) AATTT-/AAAAAA 1 -- ds50010--------
rs575253601,2
C,F--68583091(+) TCATTC/TCTCCC 1 -- ds50017Minor allele frequency- T:0.20WA NA CSA 247
rs1152514501,2
C,F--68583183(+) CACCCG/ACTTCC 1 -- ds50011Minor allele frequency- A:0.06WA 118
rs608226161,2
C,F--68583273(+) ACAGCT/CCTGTA 1 -- ds50017Minor allele frequency- C:0.20WA NA CSA 247
rs740813401,2
C--68583316(+) ATATTG/AGATAA 1 -- ds50012Minor allele frequency- A:0.11WA 120
rs1113555161,2
C,F--68583387(+) GTTTAC/AATTTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
rs1858514291,2
--68583422(+) TCTGGC/TGAGAC 1 -- ds50010--------
rs1398128031,2
--68583635(+) GTCACA/GCAGCA 1 -- ut310--------
rs1453368291,2
--68583636(+) TCACGA/CAGCAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for DIRAS3 (68511645 - 68517314 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DIRAS3: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DIRAS3
DNA2.0 Custom Variant and Variant Library Synthesis for DIRAS3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605193    OMIM disorders: --


Find genes that share disorders with DIRAS3           About GenesLikeMe

Genetic Association Database (GAD): DIRAS3
Human Genome Epidemiology (HuGE) Navigator: DIRAS3 (1 document)

Export disorders for DIRAS3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DIRAS3 gene, integrated from 10 sources (see all 36):
(articles sorted by number of sources associating them with DIRAS3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. (PubMed id 9874798)1, 2, 3, 9 Yu Y.H.... Bast R.C. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1999)
  2. NOEY2 mutations in primary breast cancers and breast hyperplasia. (PubMed id 19482475)1, 4 Yang J....Li T. (Breast 2009)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI. (PubMed id 11418188)1, 2 Luo R.Z.... Yu Y. (Biochim. Biophys. Acta 2001)
  7. ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins. (PubMed id 19435463)1, 9 Huang S....Yu Y. (Biosci. Rep. 2010)
  8. Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss. (PubMed id 18302158)1, 9 Riemenschneider M.J....Reifenberger G. (Int. J. Cancer 2008)
  9. Effect of ARHI on lung cancer cell proliferation, apoptosis and invasion in vitro. (PubMed id 23247805)1 Wu X....Fu X. (Mol. Biol. Rep. 2013)
  10. STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer. (PubMed id 23604529)1 Li J....Huang K. (Oncol. Rep. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9077 HGNC: 687 AceView: ARHI Ensembl:ENSG00000162595 euGenes: HUgn9077
ECgene: DIRAS3 H-InvDB: DIRAS3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DIRAS3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DIRAS3 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/NOEY2

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DIRAS3 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 EMD Millipore genomic analysis products

  
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 antibodies-online proteins for DIRAS3 (4 products)
       
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