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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DIRAS3 Gene

protein-coding   GIFtS: 48
GCID: GC01M068511

DIRAS Family, GTP-Binding RAS-Like 3

(Previous names: ras homolog gene family, member I)
(Previous symbol: ARHI)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DIRAS Family, GTP-Binding RAS-Like 31 2     Rho-Related GTP-Binding Protein RhoI2 3
ARHI1 2 3 5     NOEY22 3
Ras Homolog Gene Family, Member I1 2     GTP-Binding Protein Di-Ras32
Distinct Subgroup Of The Ras Family Member 32 3     RHOI3

External Ids:    HGNC: 6871   Entrez Gene: 90772   Ensembl: ENSG000001625957   OMIM: 6051935   UniProtKB: O956613   

Export aliases for DIRAS3 gene to outside databases

Previous GC identifers: GC01M068224 GC01M068284 GC01M066622


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DIRAS3 Gene:
This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but
not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele,
which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose
function is abrogated in ovarian and breast cancers. (provided by RefSeq, Oct 2010)

GeneCards Summary for DIRAS3 Gene: 
DIRAS3 (DIRAS family, GTP-binding RAS-like 3) is a protein-coding gene. Diseases associated with DIRAS3 include breast cancer, and ovarian cancer. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DIRAS3 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DIRAS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIRAS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31

DIRAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIRAS3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M068511:  view genomic region     (about GC identifiers)

Start:
68,511,645 bp from pter      End:
68,517,314 bp from pter
Size:
5,670 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DIRA3_HUMAN, O95661 (See protein sequence)
Recommended Name: GTP-binding protein Di-Ras3 precursor  
Size: 229 amino acids; 25861 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
Secondary accessions: B3KMP3

Explore the universe of human proteins at neXtProt for DIRAS3: NX_O95661

Explore proteomics data for DIRAS3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95661

  • DIRAS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DIRAS3 Protein Expression
    REFSEQ proteins: NP_004666.1  
    ENSEMBL proteins: 
     ENSP00000360020   ENSP00000378627  

    Human Recombinant Protein Products for DIRAS3: 
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    Novus Biologicals DIRAS3 Proteins
    Novus Biologicals DIRAS3 Lysate
    Sino Biological Recombinant Protein for DIRAS3
    Sino Biological Cell Lysate for DIRAS3 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    DIRAS3 for ontologies           About GeneDecksing



    DIRAS3 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry O95661

    ProtoNet protein and cluster: O95661

    UniProtKB/Swiss-Prot: DIRA3_HUMAN, O95661
    Similarity: Belongs to the small GTPase superfamily. Di-Ras family


    DIRAS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
         
    DIRAS3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DIRAS3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DIRAS3 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate DIRAS3:
    hsa-miR-579
    SwitchGear 3'UTR luciferase reporter plasmidDIRAS3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRAS3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DIRAS3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DIRAS3 (O956611 ENSP000003600204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT3P407631, ENSP000002646574EBI-6139214,EBI-518675 STRING: ENSP00000264657
    PRAMEF3ENSP000003653434STRING: ENSP00000365343
    --ENSP000003288084STRING: ENSP00000328808
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS9874798
    GO:0006184GTP catabolic process ----
    GO:0006349regulation of gene expression by genetic imprinting TAS9874798
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--

    DIRAS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DIRAS3 (DIRA3)

    Search CenterWatch for drugs/clinical trials and news about DIRAS3 / DIRA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DIRAS3 gene: 
    NM_004675.2  

    Unigene Cluster for DIRAS3:

    DIRAS family, GTP-binding RAS-like 3
    Hs.194695  [show with all ESTs]
    Unigene Representative Sequence: AK096393
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370981(uc001ded.3) ENST00000395201
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DIRAS3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DIRAS3:
    hsa-miR-579
    SwitchGear 3'UTR luciferase reporter plasmidDIRAS3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIRAS3
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    Sirion Biotech Customized lentivirus for stable overexpression of DIRAS3 
                         Customized lentivirus expression plasmids for stable overexpression of DIRAS3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIRAS3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIRAS3

    Additional mRNA sequence: 

    AK021882.1 AK096393.1 BC005362.1 CR541870.1 CR541892.1 U96750.1 

    3 DOTS entries:

    DT.105317  DT.100746681  DT.91749219 

    24/31 AceView cDNA sequences (see all 31):

    AA878446 NM_004675 U96750 BX114681 BM544956 BI599064 BG541618 BI668300 
    BG707443 BI603847 BC005362 CD513232 AL037802 AI692753 CD237061 AK096393 
    T17198 AL037822 BF967643 BF967422 AI215023 AV754822 BG708862 BI668243 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DIRAS3 expression in normal human tissues (normalized intensities)      DIRAS3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAAAAAAA
    DIRAS3 Expression
    About this image


    DIRAS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Fibroblast
             Detroit 551
             Human periodontal ligament Fibroblasts (HPLF)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human corneal endothelial cells
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Smooth Muscle (Extraembryonic Tissues)    fully expand to see all 2 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Ovary (Reproductive System)
             Human Ovarian Fibroblasts (HOF)   

    See DIRAS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DIRAS3

    SOURCE GeneReport for Unigene cluster: Hs.194695

    UniProtKB/Swiss-Prot: DIRA3_HUMAN, O95661
    Tissue specificity: Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers

        SABiosciences Custom PCR Arrays for DIRAS3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRAS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DIRAS3 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85006
    --
    39(a)
    1 → many
    3R(5610408-5615059)
    worm
    (Caenorhabditis elegans)
    Secernentea drn-16
    Protein DRN-1
    41(a)
    1 → many
    II(5270366-5271824)
            Species with no ortholog for DIRAS3

    ENSEMBL Gene Tree for DIRAS3 (if available)
    TreeFam Gene Tree for DIRAS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DIRAS3 gene
    RAP2C2  DIRAS12  RAP1B2  RALA2  RIT22  RAP2A2  RIT12  RALB2  
    RAP1A2  RAP2B2  NRAS2  DIRAS22  KRAS2  HRAS2  
    17 SIMAP similar genes for DIRAS3 using alignment to 1 protein entry:     DIRA3_HUMAN:
    DIRAS1    DIRAS2    DKFZp547A0616    RAP2A    RAP2B    RAP1A
    RAP2C    RAP1B    RASD2    RALB    RHEBL1    RIT1
    RRAS    NRAS    RIT2    MRAS    RRAS2

    DIRAS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/191 SNPs in DIRAS3 are shown (see all 191)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002709931,2
    C--68582965(+) CCCAAA/TTTAAA 1 -- ds50010--------
    rs2003395001,2
    C--68582968(+) AATTT-/AAAAAA 1 -- ds50010--------
    rs575253601,2
    C,F--68583091(+) TCATTC/TCTCCC 1 -- ds50017Minor allele frequency- T:0.20WA NA CSA 247
    rs1152514501,2
    C,F--68583183(+) CACCCG/ACTTCC 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs608226161,2
    C,F--68583273(+) ACAGCT/CCTGTA 1 -- ds50017Minor allele frequency- C:0.20WA NA CSA 247
    rs740813401,2
    C--68583316(+) ATATTG/AGATAA 1 -- ds50012Minor allele frequency- A:0.11WA 120
    rs1113555161,2
    C,F--68583387(+) GTTTAC/AATTTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1858514291,2
    --68583422(+) TCTGGC/TGAGAC 1 -- ds50010--------
    rs1398128031,2
    --68583635(+) GTCACA/GCAGCA 1 -- ut310--------
    rs1453368291,2
    --68583636(+) TCACGA/CAGCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DIRAS3 (68511645 - 68517314 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DIRAS3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DIRAS3
    DNA2.0 Custom Variant and Variant Library Synthesis for DIRAS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605193    OMIM disorders: --

    8 diseases for DIRAS3:    About MalaCards
    breast cancer    ovarian cancer    pancreatic cancer    hepatocellular carcinoma
    pancreatitis    gastric cancer    prostate cancer    prostatitis


    DIRAS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DIRAS3
    Human Genome Epidemiology (HuGE) Navigator: DIRAS3 (1 document)

    Export disorders for DIRAS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DIRAS3 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with DIRAS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. (PubMed id 9874798)1, 2, 3, 9 Yu Y.H.... Bast R.C. Jr. (1999)
    2. NOEY2 mutations in primary breast cancers and breast hyperplasia. (PubMed id 19482475)1, 4 Yang J....Li T. (2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI. (PubMed id 11418188)1, 2 Luo R.Z.... Yu Y. (2001)
    7. ARHI (DIRAS3), an imprinted tumour suppressor gene, b inds to importins and blocks nuclear import of cargo proteins. (PubMed id 19435463)1, 9 Huang S....Yu Y. (2010)
    8. Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss. (PubMed id 18302158)1, 9 Riemenschneider M.J....Reifenberger G. (2008)
    9. Expression of JMJD2A in infiltrating duct carcinoma wa s markedly higher than fibroadenoma, and associated with expression of ARHI, p53 and ER in infiltrating duct carcinoma. (PubMed id 23678541)1 Li B.X....Zhao Z.Q. (2013)
    10. The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration. (PubMed id 23157514)1 Klingauf M....Kroschewski R. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9077 HGNC: 687 AceView: ARHI Ensembl:ENSG00000162595 euGenes: HUgn9077
    ECgene: DIRAS3 H-InvDB: DIRAS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DIRAS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DIRAS3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/NOEY2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DIRAS3 gene:
    Search GeneIP for patents involving DIRAS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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