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Aliases for DIRAS3 Gene

Aliases for DIRAS3 Gene

  • DIRAS Family GTP Binding RAS Like 3 2 3
  • DIRAS Family, GTP-Binding RAS-Like 3 2 3 5
  • Distinct Subgroup Of The Ras Family Member 3 3 4
  • Rho-Related GTP-Binding Protein RhoI 3 4
  • Ras Homolog Gene Family, Member I 2 3
  • NOEY2 3 4
  • ARHI 3 4
  • RHOI 4

External Ids for DIRAS3 Gene

Previous HGNC Symbols for DIRAS3 Gene

  • ARHI

Previous GeneCards Identifiers for DIRAS3 Gene

  • GC01M068224
  • GC01M068284
  • GC01M068511
  • GC01M066622

Summaries for DIRAS3 Gene

Entrez Gene Summary for DIRAS3 Gene

  • This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

GeneCards Summary for DIRAS3 Gene

DIRAS3 (DIRAS Family GTP Binding RAS Like 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIRAS3 Gene

Genomics for DIRAS3 Gene

Regulatory Elements for DIRAS3 Gene

Enhancers for DIRAS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIRAS3 on UCSC Golden Path with GeneCards custom track

Promoters for DIRAS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIRAS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DIRAS3 Gene

68,045,962 bp from pter
68,051,733 bp from pter
5,772 bases
Minus strand

Genomic View for DIRAS3 Gene

Genes around DIRAS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIRAS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIRAS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIRAS3 Gene

Proteins for DIRAS3 Gene

  • Protein details for DIRAS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Di-Ras3
    Protein Accession:
    Secondary Accessions:
    • B3KMP3

    Protein attributes for DIRAS3 Gene

    229 amino acids
    Molecular mass:
    25861 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DIRAS3 Gene

Proteomics data for DIRAS3 Gene at MOPED

Post-translational modifications for DIRAS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIRAS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DIRAS3 Gene

Domains & Families for DIRAS3 Gene

Gene Families for DIRAS3 Gene

Protein Domains for DIRAS3 Gene

Suggested Antigen Peptide Sequences for DIRAS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Di-Ras family.
  • Belongs to the small GTPase superfamily. Di-Ras family.
genes like me logo Genes that share domains with DIRAS3: view

Function for DIRAS3 Gene

Gene Ontology (GO) - Molecular Function for DIRAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21643014
genes like me logo Genes that share ontologies with DIRAS3: view
genes like me logo Genes that share phenotypes with DIRAS3: view

Animal Model Products

CRISPR Products

miRNA for DIRAS3 Gene

miRTarBase miRNAs that target DIRAS3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIRAS3 Gene

Localization for DIRAS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIRAS3 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for DIRAS3 Gene COMPARTMENTS Subcellular localization image for DIRAS3 gene
Compartment Confidence
plasma membrane 3
cytosol 2
mitochondrion 2
extracellular 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DIRAS3 Gene

Pathways & Interactions for DIRAS3 Gene

genes like me logo Genes that share pathways with DIRAS3: view

Gene Ontology (GO) - Biological Process for DIRAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9874798
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with DIRAS3: view

No data available for SIGNOR curated interactions for DIRAS3 Gene

Drugs & Compounds for DIRAS3 Gene

No Compound Related Data Available

Transcripts for DIRAS3 Gene

mRNA/cDNA for DIRAS3 Gene

Unigene Clusters for DIRAS3 Gene

DIRAS family, GTP-binding RAS-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIRAS3 Gene

No ASD Table

Relevant External Links for DIRAS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIRAS3 Gene

mRNA expression in normal human tissues for DIRAS3 Gene

mRNA differential expression in normal tissues according to GTEx for DIRAS3 Gene

This gene is overexpressed in Brain - Hypothalamus (x15.3), Brain - Nucleus accumbens (basal ganglia) (x6.1), and Pituitary (x5.6).

SOURCE GeneReport for Unigene cluster for DIRAS3 Gene Hs.194695

mRNA Expression by UniProt/SwissProt for DIRAS3 Gene

Tissue specificity: Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.
genes like me logo Genes that share expression patterns with DIRAS3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DIRAS3 Gene

Orthologs for DIRAS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIRAS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DIRAS3 35
  • 76.75 (n)
  • 60.53 (a)
  • 60 (a)
(Pan troglodytes)
Mammalia DIRAS3 35
  • 99.85 (n)
  • 100 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
(Gallus gallus)
Aves RAP2B 36
  • 27 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
(Danio rerio)
Actinopterygii si:dkey-27j5.5 36
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8500 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea drn-1 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for DIRAS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DIRAS3 Gene

Gene Tree for DIRAS3 (if available)
Gene Tree for DIRAS3 (if available)

Paralogs for DIRAS3 Gene

Paralogs for DIRAS3 Gene

(17) SIMAP similar genes for DIRAS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DIRAS3: view

Variants for DIRAS3 Gene

Variation tolerance for DIRAS3 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DIRAS3 Gene

Disorders for DIRAS3 Gene

Relevant External Links for DIRAS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIRAS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIRAS3 Gene

Publications for DIRAS3 Gene

  1. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. (PMID: 9874798) Yu Y.H. … Bast R.C. Jr. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins. (PMID: 19435463) Huang S. … Yu Y. (Biosci. Rep. 2010) 3 23
  3. Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss. (PMID: 18302158) Riemenschneider M.J. … Reifenberger G. (Int. J. Cancer 2008) 3 23
  4. EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer. (PMID: 25077680) Fu Y. … Shen K. (Cell Biochem. Biophys. 2015) 3
  5. Structural perspective of ARHI mediated inhibition of STAT3 signaling: an insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinI^. (PMID: 25499977) Muthu K. … Ramadas K. (Cell. Signal. 2015) 3

Products for DIRAS3 Gene

Sources for DIRAS3 Gene