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Aliases for DIRAS2 Gene

Aliases for DIRAS2 Gene

  • DIRAS Family GTP Binding RAS Like 2 2 3
  • DIRAS Family, GTP-Binding RAS-Like 2 2 3 5
  • Distinct Subgroup Of The Ras Family Member 2 3 4
  • Di-Ras2 3

External Ids for DIRAS2 Gene

Previous GeneCards Identifiers for DIRAS2 Gene

  • GC09M085101
  • GC09M086672
  • GC09M088716
  • GC09M088717
  • GC09M090451
  • GC09M092411
  • GC09M093373
  • GC09M063052
  • GC09M093374
  • GC09M093379
  • GC09M093391
  • GC09M093405

Summaries for DIRAS2 Gene

Entrez Gene Summary for DIRAS2 Gene

  • DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

GeneCards Summary for DIRAS2 Gene

DIRAS2 (DIRAS Family GTP Binding RAS Like 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for DIRAS2 Gene

  • Displays low GTPase activity and exist predominantly in the GTP-bound form.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIRAS2 Gene

Genomics for DIRAS2 Gene

Regulatory Elements for DIRAS2 Gene

Enhancers for DIRAS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIRAS2 on UCSC Golden Path with GeneCards custom track

Promoters for DIRAS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIRAS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DIRAS2 Gene

90,609,832 bp from pter
90,643,105 bp from pter
33,274 bases
Minus strand

Genomic View for DIRAS2 Gene

Genes around DIRAS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIRAS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIRAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIRAS2 Gene

Proteins for DIRAS2 Gene

  • Protein details for DIRAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Di-Ras2
    Protein Accession:
    Secondary Accessions:
    • B3KVM2

    Protein attributes for DIRAS2 Gene

    199 amino acids
    Molecular mass:
    22485 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DIRAS2 Gene

neXtProt entry for DIRAS2 Gene

Proteomics data for DIRAS2 Gene at MOPED

Post-translational modifications for DIRAS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIRAS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DIRAS2 Gene

Domains & Families for DIRAS2 Gene

Gene Families for DIRAS2 Gene

Suggested Antigen Peptide Sequences for DIRAS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Di-Ras family.
  • Belongs to the small GTPase superfamily. Di-Ras family.
genes like me logo Genes that share domains with DIRAS2: view

Function for DIRAS2 Gene

Molecular function for DIRAS2 Gene

UniProtKB/Swiss-Prot Function:
Displays low GTPase activity and exist predominantly in the GTP-bound form.

Phenotypes for DIRAS2 Gene

genes like me logo Genes that share phenotypes with DIRAS2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIRAS2 Gene

Localization for DIRAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIRAS2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for DIRAS2 Gene COMPARTMENTS Subcellular localization image for DIRAS2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 12194967
genes like me logo Genes that share ontologies with DIRAS2: view

Pathways & Interactions for DIRAS2 Gene

SuperPathways for DIRAS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with DIRAS2: view

No data available for Pathways by source and SIGNOR curated interactions for DIRAS2 Gene

Drugs & Compounds for DIRAS2 Gene

(1) Drugs for DIRAS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DIRAS2: view

Transcripts for DIRAS2 Gene

mRNA/cDNA for DIRAS2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DIRAS2 Gene

DIRAS family, GTP-binding RAS-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIRAS2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: -
SP3: - - -
SP4: - -

Relevant External Links for DIRAS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIRAS2 Gene

mRNA expression in normal human tissues for DIRAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DIRAS2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.1), Brain - Cerebellum (x8.6), Brain - Frontal Cortex (BA9) (x8.1), Brain - Anterior cingulate cortex (BA24) (x6.0), and Brain - Cortex (x5.3).

Protein differential expression in normal tissues from HIPED for DIRAS2 Gene

This gene is overexpressed in Frontal cortex (28.4), Bone marrow stromal cell (20.1), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DIRAS2 Gene

SOURCE GeneReport for Unigene cluster for DIRAS2 Gene Hs.165636

mRNA Expression by UniProt/SwissProt for DIRAS2 Gene

Tissue specificity: Highly expressed in brain.
genes like me logo Genes that share expression patterns with DIRAS2: view

Protein tissue co-expression partners for DIRAS2 Gene

- Elite partner

Primer Products

Orthologs for DIRAS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIRAS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DIRAS2 35
  • 90.45 (n)
  • 96.98 (a)
  • 97 (a)
(Canis familiaris)
Mammalia DIRAS2 35
  • 91.29 (n)
  • 97.49 (a)
  • 97 (a)
(Mus musculus)
Mammalia Diras2 35
  • 91.29 (n)
  • 98.99 (a)
Diras2 16
Diras2 36
  • 99 (a)
(Pan troglodytes)
Mammalia DIRAS2 35
  • 99.16 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Diras2 35
  • 90.79 (n)
  • 98.99 (a)
(Monodelphis domestica)
Mammalia DIRAS2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
(Gallus gallus)
Aves DIRAS2 35
  • 80.57 (n)
  • 93.47 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia DIRAS2 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia diras2 35
  • 77.39 (n)
  • 92.96 (a)
(Danio rerio)
Actinopterygii LOC560940 35
  • 81.07 (n)
  • 89.45 (a)
  • 89 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005302 35
  • 69.66 (n)
  • 76.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8500 35
  • 70.83 (n)
  • 77.6 (a)
CG8500 36
  • 65 (a)
(Caenorhabditis elegans)
Secernentea drn-1 36
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5351 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
Species with no ortholog for DIRAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIRAS2 Gene

Gene Tree for DIRAS2 (if available)
Gene Tree for DIRAS2 (if available)

Paralogs for DIRAS2 Gene

Paralogs for DIRAS2 Gene

genes like me logo Genes that share paralogs with DIRAS2: view

Variants for DIRAS2 Gene

Sequence variations from dbSNP and Humsavar for DIRAS2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs689667 -- 90,618,351(+) aatga(C/T)gctga intron-variant
rs689959 -- 90,619,464(+) caaaa(A/C)aaact intron-variant
rs689970 -- 90,619,563(+) tagga(A/G)cattt intron-variant
rs690010 -- 90,619,962(+) tatgg(A/T)tccat intron-variant
rs690111 -- 90,615,008(+) AAAAC(G/T)GAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIRAS2 Gene

Variant ID Type Subtype PubMed ID
nsv893565 CNV Gain 21882294
nsv893566 CNV Gain 21882294

Variation tolerance for DIRAS2 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DIRAS2 Gene

Disorders for DIRAS2 Gene

Relevant External Links for DIRAS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIRAS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIRAS2 Gene

Publications for DIRAS2 Gene

  1. Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties. (PMID: 12194967) Kontani K. … Katada T. (J. Biol. Chem. 2002) 2 3 4 67
  2. DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders. (PMID: 21750579) Reif A. … Lesch K.P. (Neuropsychopharmacology 2011) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for DIRAS2 Gene

Sources for DIRAS2 Gene