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Aliases for DIRAS2 Gene

Aliases for DIRAS2 Gene

  • DIRAS Family, GTP-Binding RAS-Like 2 2 3
  • Distinct Subgroup Of The Ras Family Member 2 3 4
  • GTP-Binding Protein Di-Ras2 3
  • Di-Ras2 3

External Ids for DIRAS2 Gene

Summaries for DIRAS2 Gene

Entrez Gene Summary for DIRAS2 Gene

  • DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

GeneCards Summary for DIRAS2 Gene

DIRAS2 (DIRAS Family, GTP-Binding RAS-Like 2) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for DIRAS2 Gene

  • Displays low GTPase activity and exist predominantly in the GTP-bound form

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIRAS2 Gene

Genomics for DIRAS2 Gene

Genomic Location for DIRAS2 Gene

90,609,832 bp from pter
90,643,104 bp from pter
33,273 bases
Minus strand

Genomic View for DIRAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIRAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIRAS2 Gene

No data available for Regulatory Elements for DIRAS2 Gene

Proteins for DIRAS2 Gene

  • Protein details for DIRAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Di-Ras2
    Protein Accession:
    Secondary Accessions:
    • B3KVM2

    Protein attributes for DIRAS2 Gene

    199 amino acids
    Molecular mass:
    22485 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DIRAS2 Gene

neXtProt entry for DIRAS2 Gene

Proteomics data for DIRAS2 Gene at MOPED

Post-translational modifications for DIRAS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIRAS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DIRAS2 Gene

Domains for DIRAS2 Gene


  • Belongs to the small GTPase superfamily. Di-Ras family.:
    • Q96HU8
genes like me logo Genes that share domains with DIRAS2: view

No data available for Gene Families for DIRAS2 Gene

Function for DIRAS2 Gene

Molecular function for DIRAS2 Gene

UniProtKB/Swiss-Prot Function: Displays low GTPase activity and exist predominantly in the GTP-bound form

Gene Ontology (GO) - Molecular Function for DIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IDA 12194967
genes like me logo Genes that share ontologies with DIRAS2: view

Phenotypes for DIRAS2 Gene

GenomeRNAi human phenotypes for DIRAS2:
genes like me logo Genes that share phenotypes with DIRAS2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DIRAS2 Gene

Localization for DIRAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIRAS2 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for DIRAS2 Gene COMPARTMENTS Subcellular localization image for DIRAS2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IDA 12194967
GO:0016020 membrane --
genes like me logo Genes that share ontologies with DIRAS2: view

Pathways for DIRAS2 Gene

SuperPathways for DIRAS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIRAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
GO:0043406 NOT positive regulation of MAP kinase activity IDA 12194967
genes like me logo Genes that share ontologies with DIRAS2: view

No data available for Pathways by source for DIRAS2 Gene

Compounds for DIRAS2 Gene

(1) HMDB Compounds for DIRAS2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with DIRAS2: view

Transcripts for DIRAS2 Gene

mRNA/cDNA for DIRAS2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DIRAS2 Gene

DIRAS family, GTP-binding RAS-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIRAS2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: -
SP3: - - -
SP4: - -

Relevant External Links for DIRAS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIRAS2 Gene

mRNA expression in normal human tissues for DIRAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DIRAS2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (12.1), Brain - Cerebellum (8.6), Brain - Frontal Cortex (BA9) (8.1), Brain - Anterior cingulate cortex (BA24) (6.0), and Brain - Cortex (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DIRAS2 Gene

SOURCE GeneReport for Unigene cluster for DIRAS2 Gene Hs.165636

mRNA Expression by UniProt/SwissProt for DIRAS2 Gene

Tissue specificity: Highly expressed in brain.
genes like me logo Genes that share expressions with DIRAS2: view

Orthologs for DIRAS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIRAS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIRAS2 36
  • 99.16 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia DIRAS2 36
  • 90.45 (n)
  • 96.98 (a)
  • 97 (a)
(Canis familiaris)
Mammalia DIRAS2 36
  • 91.29 (n)
  • 97.49 (a)
  • 97 (a)
(Mus musculus)
Mammalia Diras2 36
  • 91.29 (n)
  • 98.99 (a)
Diras2 16
Diras2 37
  • 99 (a)
(Monodelphis domestica)
Mammalia DIRAS2 37
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 83 (a)
(Rattus norvegicus)
Mammalia Diras2 36
  • 90.79 (n)
  • 98.99 (a)
(Gallus gallus)
Aves DIRAS2 36
  • 80.57 (n)
  • 93.47 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia DIRAS2 37
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia diras2 36
  • 77.39 (n)
  • 92.96 (a)
(Danio rerio)
Actinopterygii DIRAS2 37
  • 89 (a)
LOC560940 36
  • 81.07 (n)
  • 89.45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005302 36
  • 69.66 (n)
  • 76.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8500 36
  • 70.83 (n)
  • 77.6 (a)
CG8500 37
  • 65 (a)
(Caenorhabditis elegans)
Secernentea drn-1 37
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5351 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 56 (a)
Species with no ortholog for DIRAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIRAS2 Gene

Gene Tree for DIRAS2 (if available)
Gene Tree for DIRAS2 (if available)

Paralogs for DIRAS2 Gene

Paralogs for DIRAS2 Gene

genes like me logo Genes that share paralogs with DIRAS2: view

Variants for DIRAS2 Gene

Sequence variations from dbSNP and Humsavar for DIRAS2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs471924 -- 90,639,530(-) TAGCC(C/T)GCAAG intron-variant
rs481897 -- 90,626,117(+) ggcag(A/G)ggttg intron-variant
rs496445 -- 90,630,521(-) atttt(C/T)ataaa intron-variant
rs497353 -- 90,630,608(+) cacac(A/G)atggt intron-variant
rs512067 -- 90,627,031(+) gtgct(A/G)tcttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIRAS2 Gene

Variant ID Type Subtype PubMed ID
nsv893565 CNV Gain 21882294
nsv893566 CNV Gain 21882294

Relevant External Links for DIRAS2 Gene

HapMap Linkage Disequilibrium report

Disorders for DIRAS2 Gene

Relevant External Links for DIRAS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DIRAS2: view

No data available for UniProtKB/Swiss-Prot for DIRAS2 Gene

Publications for DIRAS2 Gene

  1. Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties. (PMID: 12194967) Kontani K. … Katada T. (J. Biol. Chem. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 3 49

Products for DIRAS2 Gene

Sources for DIRAS2 Gene

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