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Aliases for DIRAS1 Gene

Aliases for DIRAS1 Gene

  • DIRAS Family GTPase 1 2 3 5
  • Distinct Subgroup Of The Ras Family Member 1 3 4
  • DIRAS Family, GTP-Binding RAS-Like 1 2 3
  • Ras-Related Inhibitor Of Cell Growth 3 4
  • Small GTP-Binding Tumor Suppressor 1 3 4
  • GBTS1 3 4
  • RIG 3 4
  • GTP-Binding Protein Di-Ras1 3
  • Di-Ras1 3

External Ids for DIRAS1 Gene

Previous GeneCards Identifiers for DIRAS1 Gene

  • GC19M002783
  • GC19M002654
  • GC19M002665
  • GC19M002484

Summaries for DIRAS1 Gene

Entrez Gene Summary for DIRAS1 Gene

  • DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

GeneCards Summary for DIRAS1 Gene

DIRAS1 (DIRAS Family GTPase 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and mitogen-activated protein kinase binding. An important paralog of this gene is DIRAS2.

UniProtKB/Swiss-Prot for DIRAS1 Gene

  • Displays low GTPase activity and exists predominantly in the GTP-bound form.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIRAS1 Gene

Genomics for DIRAS1 Gene

Regulatory Elements for DIRAS1 Gene

Enhancers for DIRAS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002726 0.5 Ensembl 19.8 -5.9 -5926 1.9 BCOR ZNF263 HLF ZMYM3 CEBPB ZNF623 ZNF7 SCRT2 MAFK SP7 DIRAS1 SLC39A3 ZNF554 ENSG00000261342 GC19P002723
GH19F002693 1.2 FANTOM5 Ensembl ENCODE 18.4 +26.3 26251 3.3 SRF ZNF146 ZNF266 ZNF514 NR2F2 ZFHX2 ZNF366 ZNF512 EED PRDM1 DIRAS1 CACTIN GNG7 ZNF77 SLC39A3 CACTIN-AS1 ZNF556 LINGO3 ENSG00000276097 PIR43863
GH19F002697 0.5 ENCODE 18.2 +22.1 22071 2.8 TBL1XR1 ASH2L ZBTB40 EED ETV6 ZNF600 CREM L3MBTL2 BHLHE40 JUNB DIRAS1 SLC39A3 GNG7 ENSG00000276097 PIR43863
GH19F002615 1.6 FANTOM5 Ensembl ENCODE 13.5 +93.8 93793 24.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 GADD45B SF3A2 GNG7 DIRAS1 LOC100288123 CACTIN-AS1 RNU6-993P SLC39A3 C19orf35 LOC101928631
GH19F002719 1 FANTOM5 ENCODE 12.9 +1.2 1181 0.9 TEAD4 BCL11B ZNF7 ZNF335 HIC1 ZFHX2 GLIS2 PATZ1 NFYB KLF8 DIRAS1 JSRP1 AES GNG7 TLE6 GC19P002709
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DIRAS1 on UCSC Golden Path with GeneCards custom track

Promoters for DIRAS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000341888 418 2001 KLF17 ZEB1 KAT2B ZNF335 GLIS2 KLF7 EGR2 SP3 REST GLIS1

Genomic Location for DIRAS1 Gene

Chromosome:
19
Start:
2,714,567 bp from pter
End:
2,721,418 bp from pter
Size:
6,852 bases
Orientation:
Minus strand

Genomic View for DIRAS1 Gene

Genes around DIRAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIRAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIRAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIRAS1 Gene

Proteins for DIRAS1 Gene

  • Protein details for DIRAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95057-DIRA1_HUMAN
    Recommended name:
    GTP-binding protein Di-Ras1
    Protein Accession:
    O95057

    Protein attributes for DIRAS1 Gene

    Size:
    198 amino acids
    Molecular mass:
    22329 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DIRAS1 Gene

neXtProt entry for DIRAS1 Gene

Post-translational modifications for DIRAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIRAS1 Gene

No data available for DME Specific Peptides for DIRAS1 Gene

Domains & Families for DIRAS1 Gene

Gene Families for DIRAS1 Gene

Suggested Antigen Peptide Sequences for DIRAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95057

UniProtKB/Swiss-Prot:

DIRA1_HUMAN :
  • Belongs to the small GTPase superfamily. Di-Ras family.
Family:
  • Belongs to the small GTPase superfamily. Di-Ras family.
genes like me logo Genes that share domains with DIRAS1: view

Function for DIRAS1 Gene

Molecular function for DIRAS1 Gene

UniProtKB/Swiss-Prot Function:
Displays low GTPase activity and exists predominantly in the GTP-bound form.

Gene Ontology (GO) - Molecular Function for DIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 12194967
GO:0005525 GTP binding IEA,IDA 12194967
GO:0051019 NOT mitogen-activated protein kinase binding IPI 12194967
genes like me logo Genes that share ontologies with DIRAS1: view
genes like me logo Genes that share phenotypes with DIRAS1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIRAS1 Gene

Localization for DIRAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIRAS1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIRAS1 Gene COMPARTMENTS Subcellular localization image for DIRAS1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,IDA 12194967
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DIRAS1: view

Pathways & Interactions for DIRAS1 Gene

SuperPathways for DIRAS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043406 NOT positive regulation of MAP kinase activity IDA 12194967
genes like me logo Genes that share ontologies with DIRAS1: view

No data available for Pathways by source and SIGNOR curated interactions for DIRAS1 Gene

Drugs & Compounds for DIRAS1 Gene

(1) Drugs for DIRAS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DIRAS1: view

Transcripts for DIRAS1 Gene

mRNA/cDNA for DIRAS1 Gene

Unigene Clusters for DIRAS1 Gene

DIRAS family, GTP-binding RAS-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIRAS1 Gene

No ASD Table

Relevant External Links for DIRAS1 Gene

GeneLoc Exon Structure for
DIRAS1
ECgene alternative splicing isoforms for
DIRAS1

Expression for DIRAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DIRAS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DIRAS1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.8), Heart - Left Ventricle (x6.5), Brain - Frontal Cortex (BA9) (x5.1), Brain - Cortex (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for DIRAS1 Gene

This gene is overexpressed in Spinal cord (17.7), Brain (14.9), Frontal cortex (13.6), Retina (11.1), and Fetal Brain (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIRAS1 Gene



Protein tissue co-expression partners for DIRAS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DIRAS1 Gene:

DIRAS1

SOURCE GeneReport for Unigene cluster for DIRAS1 Gene:

Hs.172753

mRNA Expression by UniProt/SwissProt for DIRAS1 Gene:

O95057-DIRA1_HUMAN
Tissue specificity: Highly expressed in heart and brain.
genes like me logo Genes that share expression patterns with DIRAS1: view

Primer Products

Orthologs for DIRAS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIRAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIRAS1 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia DIRAS1 34 35
  • 94.44 (n)
cow
(Bos Taurus)
Mammalia DIRAS1 34 35
  • 92.59 (n)
oppossum
(Monodelphis domestica)
Mammalia DIRAS1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Diras1 34 16 35
  • 90.07 (n)
rat
(Rattus norvegicus)
Mammalia Diras1 34
  • 89.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DIRAS1 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858997 34
  • 90.07 (n)
DIRAS1 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DIRAS1 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia diras1 34
  • 74.58 (n)
zebrafish
(Danio rerio)
Actinopterygii diras1a 35
  • 81 (a)
OneToMany
diras1b 34 35
  • 78.28 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG8500 35
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea drn-1 34 35
  • 56.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for DIRAS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIRAS1 Gene

ENSEMBL:
Gene Tree for DIRAS1 (if available)
TreeFam:
Gene Tree for DIRAS1 (if available)

Paralogs for DIRAS1 Gene

Variants for DIRAS1 Gene

Sequence variations from dbSNP and Humsavar for DIRAS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10423839 -- 2,719,754(+) CTAAG(C/T)CTCCG intron-variant, upstream-variant-2KB
rs111211856 -- 2,714,295(+) TTCTC(A/C)ACCCT downstream-variant-500B
rs111254706 -- 2,722,884(+) GGCCC(A/G)GCCCC upstream-variant-2KB
rs111545601 -- 2,721,906(+) CACCC(A/C)TCCCA upstream-variant-2KB
rs111666172 -- 2,721,498(+) GCGCG(C/G)CGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DIRAS1 Gene

Variant ID Type Subtype PubMed ID
esv2229192 CNV deletion 18987734
esv3643435 CNV loss 21293372
esv3643436 CNV gain 21293372
nsv1144854 CNV deletion 24896259
nsv470109 CNV loss 18288195
nsv509714 CNV insertion 20534489
nsv578398 CNV gain 21841781
nsv819697 CNV loss 19587683
nsv828397 CNV gain 20364138
nsv828399 CNV gain 20364138

Variation tolerance for DIRAS1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIRAS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIRAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIRAS1 Gene

Disorders for DIRAS1 Gene

Relevant External Links for DIRAS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIRAS1

No disorders were found for DIRAS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIRAS1 Gene

Publications for DIRAS1 Gene

  1. Rig is a novel Ras-related protein and potential neural tumor suppressor. (PMID: 12107278) Ellis C.A. … Clark G.J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties. (PMID: 12194967) Kontani K. … Katada T. (J. Biol. Chem. 2002) 3 4 64
  5. The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. (PMID: 26814130) Bergom C. … Williams C.L. (J. Biol. Chem. 2016) 3 64

Products for DIRAS1 Gene

Sources for DIRAS1 Gene

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