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Aliases for DIRAS1 Gene

Aliases for DIRAS1 Gene

  • DIRAS Family GTP Binding RAS Like 1 2 3
  • DIRAS Family, GTP-Binding RAS-Like 1 2 3 5
  • Distinct Subgroup Of The Ras Family Member 1 3 4
  • Ras-Related Inhibitor Of Cell Growth 3 4
  • Small GTP-Binding Tumor Suppressor 1 3 4
  • GBTS1 3 4
  • RIG 3 4
  • Di-Ras1 3

External Ids for DIRAS1 Gene

Previous GeneCards Identifiers for DIRAS1 Gene

  • GC19M002783
  • GC19M002654
  • GC19M002665
  • GC19M002484

Summaries for DIRAS1 Gene

Entrez Gene Summary for DIRAS1 Gene

  • DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

GeneCards Summary for DIRAS1 Gene

DIRAS1 (DIRAS Family GTP Binding RAS Like 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and mitogen-activated protein kinase binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for DIRAS1 Gene

  • Displays low GTPase activity and exist predominantly in the GTP-bound form.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIRAS1 Gene

Genomics for DIRAS1 Gene

Regulatory Elements for DIRAS1 Gene

Enhancers for DIRAS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIRAS1 on UCSC Golden Path with GeneCards custom track

Promoters for DIRAS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIRAS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DIRAS1 Gene

2,714,567 bp from pter
2,721,418 bp from pter
6,852 bases
Minus strand

Genomic View for DIRAS1 Gene

Genes around DIRAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIRAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIRAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIRAS1 Gene

Proteins for DIRAS1 Gene

  • Protein details for DIRAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Di-Ras1
    Protein Accession:

    Protein attributes for DIRAS1 Gene

    198 amino acids
    Molecular mass:
    22329 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DIRAS1 Gene

neXtProt entry for DIRAS1 Gene

Proteomics data for DIRAS1 Gene at MOPED

Post-translational modifications for DIRAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIRAS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DIRAS1 Gene

Domains & Families for DIRAS1 Gene

Gene Families for DIRAS1 Gene

Suggested Antigen Peptide Sequences for DIRAS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Di-Ras family.
  • Belongs to the small GTPase superfamily. Di-Ras family.
genes like me logo Genes that share domains with DIRAS1: view

Function for DIRAS1 Gene

Molecular function for DIRAS1 Gene

UniProtKB/Swiss-Prot Function:
Displays low GTPase activity and exist predominantly in the GTP-bound form.
genes like me logo Genes that share phenotypes with DIRAS1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIRAS1 Gene

Localization for DIRAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIRAS1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for DIRAS1 Gene COMPARTMENTS Subcellular localization image for DIRAS1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 12194967
genes like me logo Genes that share ontologies with DIRAS1: view

Pathways & Interactions for DIRAS1 Gene

SuperPathways for DIRAS1 Gene

No Data Available

Interacting Proteins for DIRAS1 Gene

Gene Ontology (GO) - Biological Process for DIRAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with DIRAS1: view

No data available for Pathways by source and SIGNOR curated interactions for DIRAS1 Gene

Drugs & Compounds for DIRAS1 Gene

(1) Drugs for DIRAS1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DIRAS1: view

Transcripts for DIRAS1 Gene

Unigene Clusters for DIRAS1 Gene

DIRAS family, GTP-binding RAS-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIRAS1 Gene

No ASD Table

Relevant External Links for DIRAS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIRAS1 Gene

mRNA expression in normal human tissues for DIRAS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DIRAS1 Gene

This gene is overexpressed in Heart - Atrial Appendage (x6.8), Heart - Left Ventricle (x6.5), Brain - Frontal Cortex (BA9) (x5.1), Brain - Cortex (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for DIRAS1 Gene

This gene is overexpressed in Spinal cord (17.7), Brain (14.9), Frontal cortex (13.6), Retina (11.1), and Fetal Brain (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIRAS1 Gene

SOURCE GeneReport for Unigene cluster for DIRAS1 Gene Hs.172753

mRNA Expression by UniProt/SwissProt for DIRAS1 Gene

Tissue specificity: Highly expressed in heart and brain.
genes like me logo Genes that share expression patterns with DIRAS1: view

Protein tissue co-expression partners for DIRAS1 Gene

- Elite partner

Primer Products

Orthologs for DIRAS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIRAS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DIRAS1 35
  • 92.59 (n)
  • 97.98 (a)
  • 98 (a)
(Canis familiaris)
Mammalia DIRAS1 35
  • 94.44 (n)
  • 97.47 (a)
  • 97 (a)
(Mus musculus)
Mammalia Diras1 35
  • 90.07 (n)
  • 93.94 (a)
Diras1 16
Diras1 36
  • 94 (a)
(Pan troglodytes)
Mammalia DIRAS1 35
  • 99.49 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Diras1 35
  • 89.9 (n)
  • 93.94 (a)
(Monodelphis domestica)
Mammalia DIRAS1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia DIRAS1 36
  • 58 (a)
(Gallus gallus)
Aves LOC100858997 35
  • 90.07 (n)
  • 90.4 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia DIRAS1 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia diras1 35
  • 74.58 (n)
  • 89.39 (a)
(Danio rerio)
Actinopterygii -- 35
diras1b 35
  • 78.28 (n)
  • 82.83 (a)
diras1a 36
  • 81 (a)
diras1b 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8500 36
  • 62 (a)
(Caenorhabditis elegans)
Secernentea drn-1 35
  • 56.03 (n)
  • 54.31 (a)
drn-1 36
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for DIRAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIRAS1 Gene

Gene Tree for DIRAS1 (if available)
Gene Tree for DIRAS1 (if available)

Paralogs for DIRAS1 Gene

Paralogs for DIRAS1 Gene

genes like me logo Genes that share paralogs with DIRAS1: view

Variants for DIRAS1 Gene

Sequence variations from dbSNP and Humsavar for DIRAS1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256720 -- 2,720,283(+) CAGCC(C/T)TTGCC intron-variant, upstream-variant-2KB
rs7343093 -- 2,717,882(+) TGTGC(A/G)GAGAG intron-variant
rs28435794 -- 2,715,558(+) CTGGC(A/C/G)AATGC utr-variant-3-prime
rs72980739 -- 2,715,092(+) CGCAC(A/G/T)TGTGC utr-variant-3-prime
rs72980740 -- 2,715,288(+) AGGGC(A/G)TGCGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DIRAS1 Gene

Variant ID Type Subtype PubMed ID
nsv509714 CNV Insertion 20534489
nsv910675 CNV Loss 21882294
nsv470109 CNV Loss 18288195
nsv910676 CNV Loss 21882294
dgv3641n71 CNV Loss 21882294
nsv910678 CNV Loss 21882294
nsv910680 CNV Loss 21882294
nsv828397 CNV Gain 20364138
nsv910681 CNV Loss 21882294
dgv3642n71 CNV Loss 21882294
dgv3643n71 CNV Loss 21882294
esv2229192 CNV Deletion 18987734
nsv828399 CNV Gain 20364138
nsv819697 CNV Loss 19587683
nsv910689 CNV Loss 21882294

Variation tolerance for DIRAS1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DIRAS1 Gene

Disorders for DIRAS1 Gene

Relevant External Links for DIRAS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIRAS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIRAS1 Gene

Publications for DIRAS1 Gene

  1. Rig is a novel Ras-related protein and potential neural tumor suppressor. (PMID: 12107278) Ellis C.A. … Clark G.J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. (PMID: 23436800) Zhu Y.H. … Guan X.Y. (Cancer Res. 2013) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for DIRAS1 Gene

Sources for DIRAS1 Gene