DIRAS1 Gene
protein-coding GIFtS: 46
GCID: GC19M002665
|
|
DIRAS family, GTP-binding RAS-like 1
| |
Aliases
for DIRAS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DIRAS Family, GTP-Binding RAS-Like 11 2 | | Ras-Related Inhibitor Of Cell Growth2 3 | | GBTS11 2 3 | | Small GTP-Binding Tumor Suppressor 12 3 | | RIG1 2 3 | | GTP-Binding Protein Di-Ras12 | | Di-Ras11 2 | | Rig3 | | Distinct Subgroup Of The Ras Family Member 12 3 | | |
Export aliases for DIRAS1 gene to outside databasesPrevious GC identifers: GC19M002783 GC19M002654 GC19M002484 |
Summaries
for DIRAS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DIRAS1:
DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomericGTPases.(supplied by OMIM, Apr 2004)
UniProtKB/Swiss-Prot: DIRA1_HUMAN, O95057Function: Displays low GTPase activity and exist predominantly in the GTP-bound form
|
Genomic Views
for DIRAS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DIRAS1 gene promoter:
E2F-4 E2F-3a NF-1 NF-1/L E2F-5 Pax-5 E2F-2 E2F E2F-1 COMP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DIRAS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIRAS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3DIRAS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M002665: view genomic region
(about GC identifiers)
Start:
|
2,714,565 bp from pter |
End:
|
2,721,416 bp from pter |
Size:
|
6,852 bases |
Orientation:
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minus strand |
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Proteins
for DIRAS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DIRA1_HUMAN, O95057 (See
protein sequence)Recommended Name: GTP-binding protein Di-Ras1 precursor Size: 198 amino acids; 22329 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
1 PDB 3D structure from  and Proteopedia  for DIRAS1:2GF0 (3D)
Explore the universe of human proteins at neXtProt for DIRAS1: NX_O95057
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95057
DIRAS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660156.1
ENSEMBL proteins: ENSP00000325836 ENSP00000468417 ENSP00000466733
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- |
DIRAS1 for ontologies About GeneDecksing
DIRAS1 Antibody Products:
Assay Products for DIRAS1: |
Protein
Domains /
Families
for DIRAS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DIRAS1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95057ProtoNet protein and cluster: O95057 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003577 Ras small GTPase
UniProtKB/Swiss-Prot: DIRA1_HUMAN, O95057Similarity: Belongs to the small GTPase superfamily. Di-Ras family |
Function
for DIRAS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DIRA1_HUMAN, O95057Function: Displays low GTPase activity and exist predominantly in the GTP-bound form
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIRAS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIRAS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: DIRAS1 (NM_145173) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DIRAS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIRAS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRAS1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
DIRAS1 for ontologies About GeneDecksing
|
Pathways & Interactions
for DIRAS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DIRAS1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
DIRAS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DIRAS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DIRAS1
1 HMDB Compound for DIRAS1 About this table
Search CenterWatch for drugs/clinical trials and news about DIRAS1 / DIRA1
|
Transcripts
for DIRAS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DIRAS1 gene: NM_145173.3 Unigene Cluster for DIRAS1: DIRAS family, GTP-binding RAS-like 1 Hs.172753 [show with all ESTs]Unigene Representative Sequence: NM_1451733 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000323469(uc002lwf.3) ENST00000585334 ENST00000588128
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIRAS1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIRAS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DIRAS1 (NM_145173) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DIRAS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIRAS1 |
Additional cDNA sequence: AB076888.1 AK124445.1 AK124672.1 AL833958.1 AY056037.1 AY059641.1 AY180973.1 BC017484.1 BC030660.1 1 DOTS entry: DT.449105 24/116 AceView cDNA sequences (see all 116): AI290779 AK124445 BM693797 CR614848 F11239 BC017484 BM705635 BG577052 BU623894 CR749709 CD675176 BM699757 BX952049 AY059641 BM698156 AY056037 BX645307 BQ961686 BQ424038 BQ876832 BM663937 BQ437350 BQ433241 BE718167
GeneLoc Exon Structure
|
Expression
for DIRAS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DIRAS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGTGCCCC
About this image
See DIRAS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DIRAS1
SOURCE GeneReport for Unigene cluster: Hs.172753
UniProtKB/Swiss-Prot: DIRA1_HUMAN, O95057Tissue specificity: Highly expressed in heart and brain
SABiosciences Custom PCR Arrays for DIRAS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIRAS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DIRAS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIRAS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIRAS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRAS1 |
Orthologs
for DIRAS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DIRAS1 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008589971 |
GTP-binding protein Di-Ras2-like |
90.07(n)
90.4(a) |
|
100858997 XM_003642875.1 XP_003642923.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DIRAS16 |
-- |
90(a) |
1 ↔ 1 |
AAWZ02038790(1731-2327) |
zebrafish
(Danio rerio) |
Actinopterygii |
BC044147.12 |
-- |
80.65(n) |
|
327577 BC044147.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG85006 |
-- |
62(a) |
1 → many |
3R(5610408-5615059) |
worm
(Caenorhabditis elegans) |
Secernentea |
drn-16 |
Di-Ras/Rig/Noey2 Ras-like protein homolog family m... |
49(a) |
possible ortholog |
II(5270349-5271807) |
ENSEMBL Gene Tree for DIRAS1 (if available)
TreeFam Gene Tree for DIRAS1 (if available) |
Paralogs
for DIRAS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DIRAS1 gene
- RAP2C2 RASL10B2 RAP1B2 RASD22 RAP2A2 RAP1A2 RAP2B2 RASD12
- DIRAS22 RASL10A2 DIRAS32
18/65 SIMAP similar genes for DIRAS1 using alignment to 2 protein entries: DIRA1_HUMAN (see all proteins)
(see all similar genes):DIRAS2 DIRAS3 RAP2A RAP1B RAP1A DKFZp547A0616
RAP2B RAP2C RRAS RHEB HRAS RIT2
c-bas/has NRAS KRAS RAB15 RASD1 RASD2
DIRAS1 for paralogs About GeneDecksing
|
Genomic Variants
for DIRAS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DIRAS1 (2714565 - 2721416 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DIRAS1
1 CNV: 58866 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIRAS1 |
|
Disorders
/ Diseases
for DIRAS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 DIRAS1 for disorders About MalaCards
DIRAS1 for disorders About GeneDecksing
OMIM gene information: 607862
OMIM disorders: --
Export disorders for DIRAS1 gene to outside databases
|
Publications
for DIRAS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DIRAS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DIRAS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Rig is a novel Ras-related protein and potential neural tumor suppressor. (PubMed id 12107278)1, 2, 3 Ellis C.A....Clark G.J. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties. (PubMed id 12194967)1, 2 Kontani K.... Katada T. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DIRAS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DIRAS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DIRAS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DIRAS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DIRAS1 gene:
Search GeneIP for patents involving DIRAS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DIRAS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DIRAS1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DIRAS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIRAS1 | | | OriGene Protein Over-expression Lysate for DIRAS1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DIRAS1 | | OriGene 3'-UTR Clone for DIRAS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIRAS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIRAS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DIRAS1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DIRAS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIRAS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIRAS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DIRAS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIRAS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIRAS1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DIRAS1 |
| |  |  |  |  | | | | | | Recombinant Protein for DIRAS1 |
|
 |
 |
 |
 | | | DIRAS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIRAS1 |
|  |  |  | | | | ThermoFisher Antibody for DIRAS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIRAS1 |
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