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Aliases for DIP2C Gene

Aliases for DIP2C Gene

  • Disco Interacting Protein 2 Homolog C 2 3 5
  • KIAA0934 2 3 4
  • DIP2 Homolog C 3 4
  • DIP2 Disco-Interacting Protein 2 Homolog C (Drosophila) 2
  • DIP2 Disco-Interacting Protein 2 Homolog C 3

External Ids for DIP2C Gene

Previous HGNC Symbols for DIP2C Gene

  • KIAA0934

Previous GeneCards Identifiers for DIP2C Gene

  • GC10M000312

Summaries for DIP2C Gene

Entrez Gene Summary for DIP2C Gene

  • This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]

GeneCards Summary for DIP2C Gene

DIP2C (Disco Interacting Protein 2 Homolog C) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2C Gene

Genomics for DIP2C Gene

Regulatory Elements for DIP2C Gene

Promoters for DIP2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIP2C on UCSC Golden Path with GeneCards custom track

Genomic Location for DIP2C Gene

274,190 bp from pter
689,689 bp from pter
415,500 bases
Minus strand

Genomic View for DIP2C Gene

Genes around DIP2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIP2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIP2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2C Gene

Proteins for DIP2C Gene

  • Protein details for DIP2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disco-interacting protein 2 homolog C
    Protein Accession:
    Secondary Accessions:
    • B4DPI5
    • Q5SS78

    Protein attributes for DIP2C Gene

    1556 amino acids
    Molecular mass:
    170767 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA76778.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DIP2C Gene


neXtProt entry for DIP2C Gene

Proteomics data for DIP2C Gene at MOPED

Post-translational modifications for DIP2C Gene

  • Ubiquitination at Lys 257
  • Modification sites at PhosphoSitePlus

Other Protein References for DIP2C Gene

No data available for DME Specific Peptides for DIP2C Gene

Domains & Families for DIP2C Gene

Protein Domains for DIP2C Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2C: view

No data available for Gene Families for DIP2C Gene

Function for DIP2C Gene

Gene Ontology (GO) - Molecular Function for DIP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with DIP2C: view

Phenotypes for DIP2C Gene

genes like me logo Genes that share phenotypes with DIP2C: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIP2C Gene

Localization for DIP2C Gene

Subcellular locations from

Jensen Localization Image for DIP2C Gene COMPARTMENTS Subcellular localization image for DIP2C gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DIP2C Gene

Pathways & Interactions for DIP2C Gene

SuperPathways for DIP2C Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DIP2C: view

No data available for Pathways by source and SIGNOR curated interactions for DIP2C Gene

Drugs & Compounds for DIP2C Gene

No Compound Related Data Available

Transcripts for DIP2C Gene

Unigene Clusters for DIP2C Gene

DIP2 disco-interacting protein 2 homolog C (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2C Gene

No ASD Table

Relevant External Links for DIP2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIP2C Gene

mRNA expression in normal human tissues for DIP2C Gene

Protein differential expression in normal tissues from HIPED for DIP2C Gene

This gene is overexpressed in Spinal cord (50.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIP2C Gene

SOURCE GeneReport for Unigene cluster for DIP2C Gene Hs.432397

genes like me logo Genes that share expression patterns with DIP2C: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DIP2C Gene

Orthologs for DIP2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DIP2C 35
  • 88.22 (n)
  • 98.52 (a)
DIP2C 36
  • 98 (a)
(Canis familiaris)
Mammalia LOC610591 35
  • 87.38 (n)
  • 98.18 (a)
DIP2C 36
  • 95 (a)
(Mus musculus)
Mammalia Dip2c 35
  • 87.17 (n)
  • 99.29 (a)
Dip2c 16
Dip2c 36
  • 99 (a)
(Pan troglodytes)
Mammalia DIP2C 35
  • 97.6 (n)
  • 97.75 (a)
DIP2C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dip2c 35
  • 87.19 (n)
  • 99.29 (a)
(Monodelphis domestica)
Mammalia DIP2C 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia DIP2C 36
  • 96 (a)
(Gallus gallus)
Aves DIP2C 35
  • 80.96 (n)
  • 98.27 (a)
DIP2C 36
  • 98 (a)
(Anolis carolinensis)
Reptilia DIP2C 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2c 35
  • 79.6 (n)
  • 97.21 (a)
(Danio rerio)
Actinopterygii dip2c 35
  • 79.26 (n)
  • 92.39 (a)
dip2c 36
  • 92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011333 35
  • 32.14 (n)
  • 15.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta DIP2 35
  • 57.91 (n)
  • 63.8 (a)
DIP2 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F28B3.1 35
  • 54.8 (n)
  • 55.33 (a)
F28B3.1 36
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 36
  • 54 (a)
Species with no ortholog for DIP2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2C Gene

Gene Tree for DIP2C (if available)
Gene Tree for DIP2C (if available)

Paralogs for DIP2C Gene

Paralogs for DIP2C Gene

(4) SIMAP similar genes for DIP2C Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DIP2C: view

Variants for DIP2C Gene

Sequence variations from dbSNP and Humsavar for DIP2C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_035905 A breast cancer sample
VAR_035906 A colorectal cancer sample
VAR_035907 A breast cancer sample
rs752511 -- 598,578(+) CTCAC(A/G)CCACC intron-variant
rs816568 -- 633,255(+) CTCTG(A/C/T)ACCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2C Gene

Variant ID Type Subtype PubMed ID
dgv582n71 CNV Gain 21882294
nsv466693 CNV Gain 19166990
dgv583n71 CNV Loss 21882294
esv2666164 CNV Deletion 23128226
nsv519746 CNV Loss 19592680
nsv894701 CNV Gain 21882294
esv998813 CNV Insertion 20482838
esv29290 CNV Gain+Loss 19812545
esv1678258 CNV Insertion 17803354
esv2594246 CNV Deletion 19546169
esv1320039 CNV Deletion 17803354
esv1024446 CNV Insertion 17803354
esv7892 CNV Loss 19470904
esv28717 CNV Gain 19812545
esv1103672 CNV Deletion 17803354
esv1514144 CNV Insertion 17803354
esv1755649 CNV Deletion 17803354
esv1558074 CNV Deletion 17803354
dgv584n71 CNV Gain 21882294
dgv585n71 CNV Gain 21882294
esv990983 CNV Deletion 20482838
esv2675490 CNV Deletion 23128226
esv1403517 CNV Deletion 17803354
esv9223 CNV Loss 19470904
dgv11n6 CNV Loss 16902084
esv2659464 CNV Deletion 23128226
esv2638964 CNV Deletion 19546169
esv1344682 CNV Insertion 17803354
esv997336 CNV Deletion 20482838
esv25478 CNV Gain+Loss 19812545
esv2016393 CNV Deletion 18987734
nsv512134 CNV Loss 21212237
esv2500904 CNV Deletion 19546169
esv2037768 CNV Deletion 18987734
esv29656 CNV Gain 19812545
nsv820645 CNV Deletion 20802225
esv2341391 CNV Deletion 18987734
esv3416 CNV Deletion 18987735
nsv831765 CNV Loss 17160897
nsv25193 CNV Loss 16902084
nsv524243 CNV Loss 19592680
esv28009 CNV Loss 19812545
esv2242829 CNV Deletion 18987734
esv4124 CNV Deletion 18987735
esv2663036 CNV Deletion 23128226
esv2572990 CNV Deletion 19546169
esv2665059 CNV Deletion 23128226
esv2728339 CNV Deletion 23290073
esv2328251 CNV Deletion 18987734
esv2728350 CNV Deletion 23290073
esv2728363 CNV Deletion 23290073
esv22803 CNV Loss 19812545
dgv80e201 CNV Deletion 23290073
esv2728385 CNV Deletion 23290073
esv2728396 CNV Deletion 23290073
esv1139005 CNV Insertion 17803354
esv1664973 CNV Insertion 17803354
esv2728407 CNV Deletion 23290073
esv2678056 CNV Deletion 23128226
nsv894706 CNV Loss 21882294
esv2728418 CNV Deletion 23290073
esv2728429 CNV Deletion 23290073
esv2728440 CNV Deletion 23290073
nsv5487 CNV Insertion 18451855
nsv509339 CNV Insertion 20534489
nsv894707 CNV Loss 21882294
nsv894708 CNV Loss 21882294
esv270260 CNV Insertion 20981092
nsv819504 CNV Gain 19587683
esv2728451 CNV Deletion 23290073
esv1547088 CNV Insertion 17803354
esv2728462 CNV Deletion 23290073
esv2728474 CNV Deletion 23290073
esv1439616 CNV Insertion 17803354
nsv894709 CNV Gain 21882294
esv2660097 CNV Deletion 23128226
nsv528733 CNV Gain 19592680
esv2728485 CNV Deletion 23290073
esv2728496 CNV Deletion 23290073
nsv25268 CNV Loss 16902084
esv2728507 CNV Deletion 23290073
esv2728518 CNV Deletion 23290073
dgv586n71 CNV Loss 21882294
esv2664614 CNV Deletion 23128226
nsv894712 CNV Gain 21882294
nsv466695 CNV Gain 19166990
esv2467819 CNV Insertion 19546169
esv1450884 CNV Insertion 17803354
nsv527312 CNV Loss 19592680
nsv520943 CNV Loss 19592680
nsv894713 CNV Gain 21882294
nsv894714 CNV Loss 21882294
esv2728529 CNV Deletion 23290073
esv2728540 CNV Deletion 23290073
nsv466696 CNV Gain 19166990
esv2728551 CNV Deletion 23290073
nsv818740 CNV Gain 17921354
esv1111279 CNV Insertion 17803354
esv2650676 CNV Insertion 19546169
esv2728562 CNV Deletion 23290073
esv1922448 CNV Deletion 18987734
esv2728573 CNV Deletion 23290073
dgv118n67 CNV Gain 20364138
esv2728585 CNV Deletion 23290073
esv2728596 CNV Deletion 23290073
esv2728607 CNV Deletion 23290073
esv1191119 CNV Insertion 17803354
esv2667724 CNV Deletion 23128226
esv1374087 CNV Deletion 17803354
esv2728618 CNV Deletion 23290073
esv2537541 CNV Insertion 19546169
esv21741 CNV Gain 19812545
esv2728629 CNV Deletion 23290073
esv1255045 CNV Deletion 17803354
nsv24219 CNV Loss 16902084
esv2728640 CNV Deletion 23290073
esv2728651 CNV Deletion 23290073
nsv511462 CNV Loss 21212237
dgv81e201 CNV Deletion 23290073
esv2276553 CNV Deletion 18987734
esv2728673 CNV Deletion 23290073
esv2728696 CNV Deletion 23290073
esv26085 CNV Gain 19812545
esv2728707 CNV Deletion 23290073
esv2728718 CNV Deletion 23290073
esv2728729 CNV Deletion 23290073
esv1366852 CNV Deletion 17803354
esv2728740 CNV Deletion 23290073
esv2728751 CNV Deletion 23290073
esv2728762 CNV Deletion 23290073
esv2728773 CNV Deletion 23290073
esv24994 CNV Loss 19812545

Variation tolerance for DIP2C Gene

Residual Variation Intolerance Score: 0.157% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIP2C Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2C Gene

Disorders for DIP2C Gene

Relevant External Links for DIP2C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIP2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIP2C Gene

Publications for DIP2C Gene

  1. Genome-wide association study of Alzheimer's disease with psychotic symptoms. (PMID: 22005930) Hollingworth P. … Williams J. (Mol. Psychiatry 2012) 3 48 67
  2. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  3. A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls. (PMID: 23703922) Li W.D. … Arlen Price R. (Obesity (Silver Spring) 2013) 3
  4. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3

Products for DIP2C Gene

Sources for DIP2C Gene

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