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Aliases for DIP2C Gene

Aliases for DIP2C Gene

  • Disco Interacting Protein 2 Homolog C 2 3 5
  • KIAA0934 2 3 4
  • DIP2 Homolog C 3 4
  • DIP2 Disco-Interacting Protein 2 Homolog C (Drosophila) 2
  • DIP2 Disco-Interacting Protein 2 Homolog C 3
  • Disco-Interacting Protein 2 Homolog C 3

External Ids for DIP2C Gene

Previous HGNC Symbols for DIP2C Gene

  • KIAA0934

Previous GeneCards Identifiers for DIP2C Gene

  • GC10M000312

Summaries for DIP2C Gene

Entrez Gene Summary for DIP2C Gene

  • This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008]

GeneCards Summary for DIP2C Gene

DIP2C (Disco Interacting Protein 2 Homolog C) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2A.

Additional gene information for DIP2C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2C Gene

Genomics for DIP2C Gene

Regulatory Elements for DIP2C Gene

Enhancers for DIP2C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H001498 1.4 FANTOM5 ENCODE 24.2 -809.8 -809816 1.6 PKNOX1 GLI4 ATF7 FOS SP3 YY2 JUNB TSHZ1 ZNF488 ZNF662 DIP2C LARP4B ADARB2-AS1 ADARB2 WDR37 GC10P001430
GH10H000665 1.2 ENCODE dbSUPER 21.4 +23.6 23588 1.3 PKNOX1 FEZF1 ZNF2 ZNF302 KLF7 YY2 TSHZ1 ZNF488 ZNF610 ZSCAN16 DIP2C ENSG00000237297 ZMYND11 LOC101930421 LINC00200 LOC107984285 LOC105376339
GH10H000921 0.9 ENCODE 22 -232.3 -232271 1.3 PKNOX1 ZNF493 ZFP64 ZNF121 ZNF138 ZNF354C ZNF202 ZNF654 ZNF680 OVOL3 DIP2C ZMYND11 GTPBP4 LOC107984285 LOC101930421 GC10P000921 LOC101927762
GH10H000296 1.3 Ensembl ENCODE dbSUPER 13.1 +391.9 391922 2 ZNF146 JUN ZSCAN4 ZEB1 ZFHX2 GATA3 ZNF302 ZNF157 ZNF366 FOS LOC107984285 ZMYND11 DIP2C PIR61626 PIR51140
GH10H000649 1.4 Ensembl ENCODE dbSUPER 11.5 +39.2 39223 2.5 ELF3 TBP FOXA2 ARID4B RAD21 ZSCAN9 RARA YY1 SLC30A9 CREM LOC101930421 DIP2C PRR26 LOC105376339
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DIP2C on UCSC Golden Path with GeneCards custom track

Promoters for DIP2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023382 389 1801 FOXA2 ZNF76 SIN3A ZNF2 YY1 ZNF121 GLIS2 MXD4 ZEB2 ZNF398

Genomic Locations for DIP2C Gene

Genomic Locations for DIP2C Gene
415,500 bases
Minus strand

Genomic View for DIP2C Gene

Genes around DIP2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIP2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIP2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2C Gene

Proteins for DIP2C Gene

  • Protein details for DIP2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disco-interacting protein 2 homolog C
    Protein Accession:
    Secondary Accessions:
    • B4DPI5
    • Q5SS78

    Protein attributes for DIP2C Gene

    1556 amino acids
    Molecular mass:
    170767 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA76778.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DIP2C Gene


neXtProt entry for DIP2C Gene

Post-translational modifications for DIP2C Gene

  • Ubiquitination at posLast=257257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DIP2C Gene

Domains & Families for DIP2C Gene

Gene Families for DIP2C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DIP2C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DIP2 family.
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2C: view

Function for DIP2C Gene

Phenotypes From GWAS Catalog for DIP2C Gene

Gene Ontology (GO) - Molecular Function for DIP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with DIP2C: view

Phenotypes for DIP2C Gene

genes like me logo Genes that share phenotypes with DIP2C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIP2C Gene

Localization for DIP2C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DIP2C gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DIP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DIP2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DIP2C Gene

Pathways & Interactions for DIP2C Gene

SuperPathways for DIP2C Gene

No Data Available

Interacting Proteins for DIP2C Gene

Gene Ontology (GO) - Biological Process for DIP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DIP2C: view

No data available for Pathways by source and SIGNOR curated interactions for DIP2C Gene

Drugs & Compounds for DIP2C Gene

No Compound Related Data Available

Transcripts for DIP2C Gene

Unigene Clusters for DIP2C Gene

DIP2 disco-interacting protein 2 homolog C (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2C Gene

No ASD Table

Relevant External Links for DIP2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIP2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DIP2C Gene

Protein differential expression in normal tissues from HIPED for DIP2C Gene

This gene is overexpressed in Spinal cord (50.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIP2C Gene

NURSA nuclear receptor signaling pathways regulating expression of DIP2C Gene:


SOURCE GeneReport for Unigene cluster for DIP2C Gene:


Evidence on tissue expression from TISSUES for DIP2C Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Liver(4.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with DIP2C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DIP2C Gene

Orthologs for DIP2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIP2C 33 34
  • 97.6 (n)
(Monodelphis domestica)
Mammalia DIP2C 34
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia DIP2C 34
  • 96 (a)
(Canis familiaris)
Mammalia DIP2C 34
  • 95 (a)
LOC610591 33
  • 87.38 (n)
(Bos Taurus)
Mammalia DIP2C 33 34
  • 88.22 (n)
(Rattus norvegicus)
Mammalia Dip2c 33
  • 87.19 (n)
(Mus musculus)
Mammalia Dip2c 33 16 34
  • 87.17 (n)
(Gallus gallus)
Aves DIP2C 33 34
  • 80.96 (n)
(Anolis carolinensis)
Reptilia DIP2C 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2c 33
  • 79.6 (n)
(Danio rerio)
Actinopterygii dip2c 33 34
  • 79.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta DIP2 33 34
  • 57.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011333 33
  • 32.14 (n)
(Caenorhabditis elegans)
Secernentea F28B3.1 33 34
  • 54.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 34
  • 54 (a)
Species where no ortholog for DIP2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2C Gene

Gene Tree for DIP2C (if available)
Gene Tree for DIP2C (if available)

Paralogs for DIP2C Gene

Paralogs for DIP2C Gene

(4) SIMAP similar genes for DIP2C Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DIP2C: view

Variants for DIP2C Gene

Sequence variations from dbSNP and Humsavar for DIP2C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs771008735 A colorectal cancer sample 384,039(+) CGCGC(C/T)GTCCG reference, missense
VAR_035905 A breast cancer sample
VAR_035907 A breast cancer sample
rs1000010531 -- 616,108(+) CCCAG(G/T)TCATC intron-variant
rs1000011425 -- 428,198(+) AACCA(C/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2C Gene

Variant ID Type Subtype PubMed ID
nsv1119774 CNV deletion 24896259
nsv1119775 CNV deletion 24896259
nsv1120209 CNV tandem duplication 24896259
nsv1120210 CNV tandem duplication 24896259
nsv1121799 CNV deletion 24896259
nsv1121800 CNV deletion 24896259
nsv1121801 CNV deletion 24896259
nsv1124608 CNV duplication 24896259
nsv1126238 CNV deletion 24896259
nsv1128633 CNV duplication 24896259
nsv1129142 CNV insertion 24896259
nsv1129484 CNV tandem duplication 24896259
nsv1129485 CNV tandem duplication 24896259
nsv1132327 CNV duplication 24896259
nsv1140113 CNV insertion 24896259
nsv1140441 CNV tandem duplication 24896259
nsv1142085 CNV tandem duplication 24896259
nsv1143486 CNV deletion 24896259
nsv1145420 CNV deletion 24896259
nsv1145870 CNV deletion 26484159
nsv1146199 CNV duplication 26484159
nsv1146678 CNV insertion 26484159
nsv1148829 CNV insertion 26484159
nsv1152052 CNV duplication 26484159
nsv24219 CNV deletion 16902084
nsv25193 CNV deletion 16902084
nsv25268 CNV deletion 16902084
nsv466693 CNV gain 19166990
nsv466695 CNV gain 19166990
nsv466696 CNV gain 19166990
nsv1119411 CNV insertion 24896259
nsv1115384 CNV duplication 24896259
nsv1113238 CNV deletion 24896259
nsv1113237 CNV deletion 24896259
nsv1112570 CNV deletion 24896259
nsv1111021 CNV tandem duplication 24896259
nsv1077315 CNV duplication 25765185
nsv1077314 CNV duplication 25765185
nsv1069438 CNV deletion 25765185
nsv1069437 CNV deletion 25765185
nsv1069436 CNV deletion 25765185
nsv1069435 CNV deletion 25765185
nsv1069002 CNV deletion 25765185
nsv1068655 CNV deletion 25765185
nsv1068654 CNV deletion 25765185
nsv1068260 CNV deletion 25765185
nsv1068259 CNV deletion 25765185
nsv1068258 CNV deletion 25765185
nsv1044267 CNV gain 25217958
nsv1035990 CNV loss 25217958
esv998813 CNV insertion 20482838
esv997336 CNV deletion 20482838
esv990983 CNV deletion 20482838
esv9223 CNV loss 19470904
esv7892 CNV loss 19470904
esv4124 CNV loss 18987735
esv3891734 CNV gain 25118596
esv3622081 CNV gain 21293372
esv3622080 CNV loss 21293372
esv3622079 CNV loss 21293372
esv3622078 CNV loss 21293372
esv3576016 CNV gain 25503493
esv3545701 CNV deletion 23714750
esv3545695 CNV deletion 23714750
esv3545694 CNV deletion 23714750
esv3545686 CNV deletion 23714750
esv3416 CNV loss 18987735
esv3335198 CNV insertion 20981092
esv3305983 CNV mobile element insertion 20981092
esv3265495 CNV deletion 24192839
esv29656 CNV gain 19812545
esv29290 CNV gain+loss 19812545
esv28717 CNV gain 19812545
esv28009 CNV loss 19812545
esv2728773 CNV deletion 23290073
esv2728762 CNV deletion 23290073
esv2728751 CNV deletion 23290073
esv2728740 CNV deletion 23290073
esv2728729 CNV deletion 23290073
esv2728718 CNV deletion 23290073
esv2728707 CNV deletion 23290073
esv2728696 CNV deletion 23290073
esv2728673 CNV deletion 23290073
esv2728651 CNV deletion 23290073
esv2728640 CNV deletion 23290073
esv2728629 CNV deletion 23290073
esv2728618 CNV deletion 23290073
esv2728607 CNV deletion 23290073
esv2728596 CNV deletion 23290073
esv2728585 CNV deletion 23290073
esv2728573 CNV deletion 23290073
esv2728562 CNV deletion 23290073
esv2728551 CNV deletion 23290073
esv2728540 CNV deletion 23290073
esv2728529 CNV deletion 23290073
esv2728518 CNV deletion 23290073
esv2728507 CNV deletion 23290073
esv2728496 CNV deletion 23290073
esv2728485 CNV deletion 23290073
esv2728474 CNV deletion 23290073
esv2728462 CNV deletion 23290073
esv2728451 CNV deletion 23290073
esv2728440 CNV deletion 23290073
esv2728429 CNV deletion 23290073
esv2728418 CNV deletion 23290073
esv2728407 CNV deletion 23290073
esv2728396 CNV deletion 23290073
esv2728385 CNV deletion 23290073
esv2728363 CNV deletion 23290073
esv2728350 CNV deletion 23290073
esv2728339 CNV deletion 23290073
esv2678056 CNV deletion 23128226
esv2675490 CNV deletion 23128226
esv2667724 CNV deletion 23128226
esv2666164 CNV deletion 23128226
esv2665059 CNV deletion 23128226
esv2664614 CNV deletion 23128226
esv2663036 CNV deletion 23128226
esv2660097 CNV deletion 23128226
esv2659464 CNV deletion 23128226
esv2650676 CNV insertion 19546169
esv2638964 CNV deletion 19546169
esv26085 CNV gain 19812545
esv2594246 CNV deletion 19546169
esv2572990 CNV deletion 19546169
esv25478 CNV gain+loss 19812545
esv2537541 CNV insertion 19546169
esv2500904 CNV deletion 19546169
esv24994 CNV loss 19812545
esv2467819 CNV insertion 19546169
esv2341391 CNV deletion 18987734
esv2328251 CNV deletion 18987734
esv22803 CNV loss 19812545
esv2276553 CNV deletion 18987734
esv2242829 CNV deletion 18987734
esv21741 CNV gain 19812545
esv2037768 CNV deletion 18987734
esv2016393 CNV deletion 18987734
esv1922448 CNV deletion 18987734
esv1755649 CNV deletion 17803354
esv1678258 CNV insertion 17803354
esv1664973 CNV insertion 17803354
esv1558074 CNV deletion 17803354
esv1547088 CNV insertion 17803354
esv1514144 CNV insertion 17803354
esv1450884 CNV insertion 17803354
esv1439616 CNV insertion 17803354
esv1403517 CNV deletion 17803354
esv1374087 CNV deletion 17803354
esv1366852 CNV deletion 17803354
esv1344682 CNV insertion 17803354
esv1320039 CNV deletion 17803354
esv1255045 CNV deletion 17803354
esv1191119 CNV insertion 17803354
esv1139005 CNV insertion 17803354
esv1111279 CNV insertion 17803354
esv1103672 CNV deletion 17803354
esv1024446 CNV insertion 17803354
dgv924n54 CNV gain 21841781
dgv69e201 CNV deletion 23290073
dgv68e201 CNV deletion 23290073
dgv653n100 CNV gain 25217958
dgv652n100 CNV gain 25217958
dgv651n100 CNV gain 25217958
dgv341e59 CNV duplication 20981092
dgv340e59 CNV duplication 20981092
dgv339e59 CNV duplication 20981092
dgv332n106 CNV duplication 24896259
dgv331n106 CNV deletion 24896259
dgv330n106 CNV deletion 24896259
dgv329n106 CNV deletion 24896259
dgv26e215 CNV deletion 23714750
dgv11n6 CNV deletion 16902084
dgv118n67 CNV gain 20364138
nsv975789 CNV duplication 23825009
nsv957667 CNV deletion 24416366
nsv951226 CNV deletion 24416366
nsv951225 CNV deletion 24416366
nsv951224 CNV deletion 24416366
nsv951223 CNV deletion 24416366
nsv951222 CNV deletion 24416366
nsv951221 CNV deletion 24416366
nsv831765 CNV loss 17160897
nsv820645 CNV deletion 20802225
nsv819504 CNV gain 19587683
nsv818740 CNV gain 17921354
nsv549765 CNV gain 21841781
nsv549764 CNV loss 21841781
nsv549763 CNV gain 21841781
nsv549762 CNV loss 21841781
nsv549759 CNV loss 21841781
nsv549758 CNV loss 21841781
nsv549757 CNV loss 21841781
nsv549756 CNV gain 21841781
nsv549755 CNV loss 21841781
nsv549754 CNV loss 21841781
nsv549753 CNV gain 21841781
nsv549752 CNV loss 21841781
nsv549751 CNV gain 21841781
nsv549750 CNV gain 21841781
nsv5487 CNV insertion 18451855
nsv528733 CNV gain 19592680
nsv527312 CNV loss 19592680
nsv524243 CNV loss 19592680
nsv520943 CNV loss 19592680
nsv519746 CNV loss 19592680
nsv512134 CNV loss 21212237
nsv511462 CNV loss 21212237
nsv509339 CNV insertion 20534489
nsv477039 CNV novel sequence insertion 20440878

Variation tolerance for DIP2C Gene

Residual Variation Intolerance Score: 0.157% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.72; 32.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIP2C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2C Gene

Disorders for DIP2C Gene

Relevant External Links for DIP2C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIP2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIP2C Gene

Publications for DIP2C Gene

  1. Genome-wide association study of Alzheimer's disease with psychotic symptoms. (PMID: 22005930) Hollingworth P … Williams J (Molecular psychiatry 2012) 3 45 60
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for DIP2C Gene

Sources for DIP2C Gene

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