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Aliases for DIP2B Gene

Aliases for DIP2B Gene

  • Disco Interacting Protein 2 Homolog B 2 3 5
  • DIP2 Disco-Interacting Protein 2 Homolog B (Drosophila) 2
  • DIP2 Homolog B 4
  • KIAA1463 4

External Ids for DIP2B Gene

Previous GeneCards Identifiers for DIP2B Gene

  • GC12U900523
  • GC12P049187
  • GC12P050898
  • GC12P047931

Summaries for DIP2B Gene

Entrez Gene Summary for DIP2B Gene

  • This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]

GeneCards Summary for DIP2B Gene

DIP2B (Disco Interacting Protein 2 Homolog B) is a Protein Coding gene. Diseases associated with DIP2B include Mental Retardation, Fra12a Type and X-Linked Hereditary Ataxia. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2B Gene

Genomics for DIP2B Gene

Regulatory Elements for DIP2B Gene

Enhancers for DIP2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIP2B on UCSC Golden Path with GeneCards custom track

Promoters for DIP2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIP2B on UCSC Golden Path with GeneCards custom track

Genomic Location for DIP2B Gene

50,504,985 bp from pter
50,748,667 bp from pter
243,683 bases
Plus strand

Genomic View for DIP2B Gene

Genes around DIP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2B Gene

Proteins for DIP2B Gene

  • Protein details for DIP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disco-interacting protein 2 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q6B011
    • Q8N1L5
    • Q8NB38

    Protein attributes for DIP2B Gene

    1576 amino acids
    Molecular mass:
    171492 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH75027.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC05025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW58149.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DIP2B Gene

Proteomics data for DIP2B Gene at MOPED

Post-translational modifications for DIP2B Gene

  • Ubiquitination at Lys 47, Lys 65, Lys 276, Lys 480, Lys 714, Lys 1300, and Lys 1367
  • Modification sites at PhosphoSitePlus

Other Protein References for DIP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DIP2B Gene

Domains & Families for DIP2B Gene

Protein Domains for DIP2B Gene

Suggested Antigen Peptide Sequences for DIP2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2B: view

No data available for Gene Families for DIP2B Gene

Function for DIP2B Gene

Gene Ontology (GO) - Molecular Function for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with DIP2B: view
genes like me logo Genes that share phenotypes with DIP2B: view

Human Phenotype Ontology for DIP2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DIP2B Gene

MGI Knock Outs for DIP2B:

Animal Model Products

miRNA for DIP2B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DIP2B Gene

Localization for DIP2B Gene

Subcellular locations from

Jensen Localization Image for DIP2B Gene COMPARTMENTS Subcellular localization image for DIP2B gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DIP2B Gene

Pathways & Interactions for DIP2B Gene

SuperPathways for DIP2B Gene

No Data Available

Interacting Proteins for DIP2B Gene

Gene Ontology (GO) - Biological Process for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DIP2B: view

No data available for Pathways by source and SIGNOR curated interactions for DIP2B Gene

Drugs & Compounds for DIP2B Gene

No Compound Related Data Available

Transcripts for DIP2B Gene

mRNA/cDNA for DIP2B Gene

(9) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DIP2B Gene

DIP2 disco-interacting protein 2 homolog B (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP2: -

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b

Relevant External Links for DIP2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIP2B Gene

mRNA expression in normal human tissues for DIP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DIP2B Gene

This gene is overexpressed in Cervix (19.4), Breast (10.0), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIP2B Gene

SOURCE GeneReport for Unigene cluster for DIP2B Gene Hs.505516

mRNA Expression by UniProt/SwissProt for DIP2B Gene

Tissue specificity: Moderately expressed in adult brain, placenta, skeletal muscle, heart, kidney, pancreas, lung, spleen and colon. Expression was weaker in adult liver, kidney, spleen, and ovary, and in fetal brain and liver. In the brain, it is expressed in the cerebral cortex; the frontal, parietal, occipital and temporal lobes; the paracentral gyrus; the pons; the corpus callosum and the hippocampus. Highest expression levels in the brain were found in the cerebral cortex and the frontal and parietal lobes.
genes like me logo Genes that share expression patterns with DIP2B: view

Protein tissue co-expression partners for DIP2B Gene

Primer Products

No data available for mRNA differential expression in normal tissues for DIP2B Gene

Orthologs for DIP2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DIP2B 35
  • 92.04 (n)
  • 98.92 (a)
DIP2B 36
  • 99 (a)
(Canis familiaris)
Mammalia DIP2B 35
  • 93.42 (n)
  • 98.98 (a)
DIP2B 36
  • 99 (a)
(Mus musculus)
Mammalia Dip2b 35
  • 89.11 (n)
  • 98.09 (a)
Dip2b 16
Dip2b 36
  • 98 (a)
(Pan troglodytes)
Mammalia DIP2B 35
  • 99.58 (n)
  • 99.68 (a)
DIP2B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dip2b 35
  • 88.39 (n)
  • 97.8 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
-- 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
-- 36
  • 91 (a)
-- 36
  • 61 (a)
(Gallus gallus)
Aves DIP2B 35
  • 82.71 (n)
  • 93.72 (a)
DIP2B 36
  • 93 (a)
(Anolis carolinensis)
Reptilia DIP2B 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2b 35
  • 77.13 (n)
  • 88.68 (a)
(Danio rerio)
Actinopterygii dip2ba 35
  • 72.04 (n)
  • 82.01 (a)
DIP2B (2 of 2) 36
  • 78 (a)
dip2ba 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta DIP2 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea F28B3.1 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 20 (a)
CMR2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 36
  • 52 (a)
Species with no ortholog for DIP2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2B Gene

Gene Tree for DIP2B (if available)
Gene Tree for DIP2B (if available)

Paralogs for DIP2B Gene

Paralogs for DIP2B Gene

(3) SIMAP similar genes for DIP2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DIP2B: view

Variants for DIP2B Gene

Sequence variations from dbSNP and Humsavar for DIP2B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11169525 - 50,704,188(+) CATTC(A/G)TCCGA reference, missense
rs1967576 -- 50,624,333(-) AGAAA(G/T)AAAGT intron-variant
rs1975351 -- 50,741,384(+) TGTCC(A/C/G)AGCCA intron-variant
rs1996750 -- 50,633,514(+) TGGCT(C/T)ATGCC intron-variant
rs2012313 -- 50,670,431(-) ctcaa(A/C)aacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2B Gene

Variant ID Type Subtype PubMed ID
esv1512829 CNV Deletion 17803354
esv27734 CNV Loss 19812545
esv3400 CNV Deletion 18987735
dgv289n67 CNV Loss 20364138
esv2745873 CNV Deletion 23290073
esv2678706 CNV Deletion 23128226
esv9262 CNV Loss 19470904

Variation tolerance for DIP2B Gene

Residual Variation Intolerance Score: 1.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIP2B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2B Gene

Disorders for DIP2B Gene

MalaCards: The human disease database

(3) MalaCards diseases for DIP2B Gene - From: OMIM, ClinVar, and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DIP2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIP2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DIP2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIP2B Gene

Publications for DIP2B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. (PMID: 24737748) Whiffin N. … Dunlop M.G. (Hum. Mol. Genet. 2014) 3
  5. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. (PMID: 23969696) Sabater-Lleal M. … O'Donnell C.J. (Circulation 2013) 3

Products for DIP2B Gene

Sources for DIP2B Gene