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Aliases for DIP2B Gene

Aliases for DIP2B Gene

  • Disco Interacting Protein 2 Homolog B 2 3 5
  • DIP2 Disco-Interacting Protein 2 Homolog B (Drosophila) 2
  • DIP2 Homolog B 4
  • KIAA1463 4

External Ids for DIP2B Gene

Previous GeneCards Identifiers for DIP2B Gene

  • GC12U900523
  • GC12P049187
  • GC12P050898
  • GC12P047931

Summaries for DIP2B Gene

Entrez Gene Summary for DIP2B Gene

  • This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]

GeneCards Summary for DIP2B Gene

DIP2B (Disco Interacting Protein 2 Homolog B) is a Protein Coding gene. Diseases associated with DIP2B include Mental Retardation, Fra12a Type and X-Linked Hereditary Ataxia. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2C.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2B Gene

Genomics for DIP2B Gene

Regulatory Elements for DIP2B Gene

Enhancers for DIP2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F050536 1.5 FANTOM5 Ensembl ENCODE 11.5 +33.1 33108 2.6 PKNOX1 ATF1 ARID4B SIN3A YY1 FOS NFYC MXD4 PPARG KAT8 ATF1 CERS5 RNU6-769P DIP2B LIMA1 SLC11A2 GC12P050634
GH12F050541 1.1 FANTOM5 Ensembl ENCODE 10.7 +37.4 37431 2.7 HDAC1 CBX3 PKNOX1 TBL1XR1 RAD21 YY1 RARA ZNF766 GATA2 FOS ATF1 CERS5 RNU6-769P DIP2B GC12P050634
GH12F050530 0.9 Ensembl ENCODE 10.5 +28.1 28099 4.6 HDGF MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS RPL35AP28 CERS5 ENSG00000257253 RNU6-769P FAM186A DIP2B LOC283332 LIMA1 AQP6 GC12P050634
GH12F050547 0.9 Ensembl ENCODE 10.4 +44.6 44589 3.7 ELF3 HDAC1 PKNOX1 ARID4B ZSCAN9 RAD21 YY1 RARA ZNF121 ELK1 LIMA1 CERS5 RNU6-769P ATF1 DIP2B GC12P050634
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DIP2B on UCSC Golden Path with GeneCards custom track

Promoters for DIP2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000430334 616 3200 ARNT CREB3L1 ARID4B SIN3A YY1 CBX5 ZNF143 KLF13 DEK ZNF263

Genomic Location for DIP2B Gene

50,504,985 bp from pter
50,748,667 bp from pter
243,683 bases
Plus strand

Genomic View for DIP2B Gene

Genes around DIP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2B Gene

Proteins for DIP2B Gene

  • Protein details for DIP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disco-interacting protein 2 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q6B011
    • Q8N1L5
    • Q8NB38

    Protein attributes for DIP2B Gene

    1576 amino acids
    Molecular mass:
    171492 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH75027.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC05025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW58149.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DIP2B Gene

Post-translational modifications for DIP2B Gene

  • Ubiquitination at Lys 47, Lys 65, Lys 276, Lys 480, Lys 714, Lys 1300, and Lys 1367
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DIP2B Gene

Domains & Families for DIP2B Gene

Protein Domains for DIP2B Gene

Suggested Antigen Peptide Sequences for DIP2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2B: view

No data available for Gene Families for DIP2B Gene

Function for DIP2B Gene

Gene Ontology (GO) - Molecular Function for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with DIP2B: view
genes like me logo Genes that share phenotypes with DIP2B: view

Human Phenotype Ontology for DIP2B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DIP2B Gene

MGI Knock Outs for DIP2B:

Animal Model Products

miRNA for DIP2B Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DIP2B Gene

Localization for DIP2B Gene

Subcellular locations from

Jensen Localization Image for DIP2B Gene COMPARTMENTS Subcellular localization image for DIP2B gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15531550
GO:0005737 cytoplasm IDA 15531550
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DIP2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DIP2B Gene

Pathways & Interactions for DIP2B Gene

SuperPathways for DIP2B Gene

No Data Available

Interacting Proteins for DIP2B Gene

Gene Ontology (GO) - Biological Process for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DIP2B: view

No data available for Pathways by source and SIGNOR curated interactions for DIP2B Gene

Transcripts for DIP2B Gene

mRNA/cDNA for DIP2B Gene

(15) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DIP2B Gene

DIP2 disco-interacting protein 2 homolog B (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP2: -

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b

Relevant External Links for DIP2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIP2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DIP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DIP2B Gene

This gene is overexpressed in Cervix (19.4), Breast (10.0), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIP2B Gene

Protein tissue co-expression partners for DIP2B Gene

NURSA nuclear receptor signaling pathways regulating expression of DIP2B Gene:


SOURCE GeneReport for Unigene cluster for DIP2B Gene:


mRNA Expression by UniProt/SwissProt for DIP2B Gene:

Tissue specificity: Moderately expressed in adult brain, placenta, skeletal muscle, heart, kidney, pancreas, lung, spleen and colon. Expression was weaker in adult liver, kidney, spleen, and ovary, and in fetal brain and liver. In the brain, it is expressed in the cerebral cortex; the frontal, parietal, occipital and temporal lobes; the paracentral gyrus; the pons; the corpus callosum and the hippocampus. Highest expression levels in the brain were found in the cerebral cortex and the frontal and parietal lobes.
genes like me logo Genes that share expression patterns with DIP2B: view

Primer Products

No data available for mRNA differential expression in normal tissues for DIP2B Gene

Orthologs for DIP2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIP2B 34 35
  • 99.58 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
-- 35
  • 97 (a)
(Canis familiaris)
Mammalia DIP2B 34 35
  • 93.42 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
-- 35
  • 91 (a)
-- 35
  • 61 (a)
(Bos Taurus)
Mammalia DIP2B 34 35
  • 92.04 (n)
(Mus musculus)
Mammalia Dip2b 34 16 35
  • 89.11 (n)
(Rattus norvegicus)
Mammalia Dip2b 34
  • 88.39 (n)
(Gallus gallus)
Aves DIP2B 34 35
  • 82.71 (n)
(Anolis carolinensis)
Reptilia DIP2B 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2b 34
  • 77.13 (n)
(Danio rerio)
Actinopterygii DIP2B (2 of 2) 35
  • 78 (a)
dip2ba 34 35
  • 72.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta DIP2 35
  • 50 (a)
(Caenorhabditis elegans)
Secernentea F28B3.1 35
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 20 (a)
CMR2 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 35
  • 52 (a)
Species where no ortholog for DIP2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2B Gene

Gene Tree for DIP2B (if available)
Gene Tree for DIP2B (if available)

Paralogs for DIP2B Gene

Paralogs for DIP2B Gene

(3) SIMAP similar genes for DIP2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DIP2B: view

Variants for DIP2B Gene

Sequence variations from dbSNP and Humsavar for DIP2B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1003033 -- 50,665,777(+) ACTGA(A/G)AAAAA intron-variant
rs10431486 -- 50,547,242(+) TAAAA(C/T)AGTGA intron-variant
rs10431532 -- 50,545,470(+) tcttg(A/G)gctca intron-variant
rs10431533 -- 50,547,157(+) CCTTT(A/T)TATAG intron-variant
rs10431534 -- 50,547,308(+) ATACT(C/T)Agtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2B Gene

Variant ID Type Subtype PubMed ID
dgv2619n54 CNV loss 21841781
dgv2620n54 CNV loss 21841781
dgv2621n54 CNV loss 21841781
dgv289n67 CNV loss 20364138
esv1512829 CNV deletion 17803354
esv2678706 CNV deletion 23128226
esv2745873 CNV deletion 23290073
esv27734 CNV loss 19812545
esv3400 CNV loss 18987735
esv3549195 CNV deletion 23714750
esv3629484 CNV loss 21293372
esv9262 CNV loss 19470904
nsv1068680 CNV deletion 25765185
nsv1069664 CNV deletion 25765185
nsv1113481 CNV deletion 24896259
nsv476740 CNV novel sequence insertion 20440878
nsv558842 CNV loss 21841781
nsv558850 CNV loss 21841781

Variation tolerance for DIP2B Gene

Residual Variation Intolerance Score: 1.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIP2B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2B Gene

Disorders for DIP2B Gene

MalaCards: The human disease database

(3) MalaCards diseases for DIP2B Gene - From: OMIM, ClinVar, and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DIP2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIP2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DIP2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIP2B Gene

Publications for DIP2B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. (PMID: 20972440) Houlston R.S. … Tomlinson I.P. (Nat. Genet. 2010) 3 46 64
  3. CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. (PMID: 17236128) Winnepenninckx B. … Kooy R.F. (Am. J. Hum. Genet. 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for DIP2B Gene

Sources for DIP2B Gene

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