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Aliases for DIP2B Gene

Aliases for DIP2B Gene

  • DIP2 Disco-Interacting Protein 2 Homolog B (Drosophila) 2 3
  • KIAA1463 4 6
  • DIP2 Homolog B 4

External Ids for DIP2B Gene

Previous GeneCards Identifiers for DIP2B Gene

  • GC12U900523
  • GC12P049187
  • GC12P050898
  • GC12P047931

Summaries for DIP2B Gene

Entrez Gene Summary for DIP2B Gene

  • This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]

GeneCards Summary for DIP2B Gene

DIP2B (DIP2 Disco-Interacting Protein 2 Homolog B (Drosophila)) is a Protein Coding gene. Diseases associated with DIP2B include mental retardation, fra12a type. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2B Gene

Genomics for DIP2B Gene

Regulatory Elements for DIP2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DIP2B Gene

Start:
50,504,985 bp from pter
End:
50,748,667 bp from pter
Size:
243,683 bases
Orientation:
Plus strand

Genomic View for DIP2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2B Gene

Proteins for DIP2B Gene

  • Protein details for DIP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P265-DIP2B_HUMAN
    Recommended name:
    Disco-interacting protein 2 homolog B
    Protein Accession:
    Q9P265
    Secondary Accessions:
    • Q6B011
    • Q8N1L5
    • Q8NB38

    Protein attributes for DIP2B Gene

    Size:
    1576 amino acids
    Molecular mass:
    171492 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH75027.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC05025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW58149.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DIP2B Gene

Proteomics data for DIP2B Gene at MOPED

Post-translational modifications for DIP2B Gene

  • Ubiquitination at Lys47, Lys65, Lys276, Lys480, Lys714, Lys1300, and Lys1367
  • Modification sites at PhosphoSitePlus

Other Protein References for DIP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DIP2B Gene

Domains for DIP2B Gene

Protein Domains for DIP2B Gene

Suggested Antigen Peptide Sequences for DIP2B Gene

Graphical View of Domain Structure for InterPro Entry

Q9P265

UniProtKB/Swiss-Prot:

DIP2B_HUMAN :
  • Q9P265
Domain:
  • Contains 1 DMAP-interaction domain.
Family:
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2B: view

No data available for Gene Families for DIP2B Gene

Function for DIP2B Gene

Gene Ontology (GO) - Molecular Function for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with DIP2B: view
genes like me logo Genes that share phenotypes with DIP2B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DIP2B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DIP2B Gene

Localization for DIP2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIP2B Gene COMPARTMENTS Subcellular localization image for DIP2B gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15531550
GO:0005737 cytoplasm IDA 15531550
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DIP2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DIP2B Gene

Pathways for DIP2B Gene

SuperPathways for DIP2B Gene

No Data Available

Interacting Proteins for DIP2B Gene

Gene Ontology (GO) - Biological Process for DIP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DIP2B: view

No data available for Pathways by source for DIP2B Gene

Transcripts for DIP2B Gene

mRNA/cDNA for DIP2B Gene

(9) Additional mRNA sequences :
(9) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DIP2B Gene

DIP2 disco-interacting protein 2 homolog B (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DIP2B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2: -

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b
SP1:
SP2:

Relevant External Links for DIP2B Gene

GeneLoc Exon Structure for
DIP2B
ECgene alternative splicing isoforms for
DIP2B

Expression for DIP2B Gene

mRNA expression in normal human tissues for DIP2B Gene

Protein differential expression in normal tissues for DIP2B Gene

This gene is overexpressed in Cervix (19.4), Breast (10.0), and Frontal cortex (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIP2B Gene

SOURCE GeneReport for Unigene cluster for DIP2B Gene Hs.505516

mRNA Expression by UniProt/SwissProt for DIP2B Gene

Q9P265-DIP2B_HUMAN
Tissue specificity: Moderately expressed in adult brain, placenta, skeletal muscle, heart, kidney, pancreas, lung, spleen and colon. Expression was weaker in adult liver, kidney, spleen, and ovary, and in fetal brain and liver. In the brain, it is expressed in the cerebral cortex; the frontal, parietal, occipital and temporal lobes; the paracentral gyrus; the pons; the corpus callosum and the hippocampus. Highest expression levels in the brain were found in the cerebral cortex and the frontal and parietal lobes.
genes like me logo Genes that share expressions with DIP2B: view

Expression partners for DIP2B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DIP2B Gene

Orthologs for DIP2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DIP2B 35
  • 92.04 (n)
  • 98.92 (a)
DIP2B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DIP2B 35
  • 93.42 (n)
  • 98.98 (a)
DIP2B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dip2b 35
  • 89.11 (n)
  • 98.09 (a)
Dip2b 16
Dip2b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DIP2B 35
  • 99.58 (n)
  • 99.68 (a)
DIP2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dip2b 35
  • 88.39 (n)
  • 97.8 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves DIP2B 35
  • 82.71 (n)
  • 93.72 (a)
DIP2B 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DIP2B 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2b 35
  • 77.13 (n)
  • 88.68 (a)
zebrafish
(Danio rerio)
Actinopterygii dip2ba 35
  • 72.04 (n)
  • 82.01 (a)
DIP2B (2 of 2) 36
  • 78 (a)
OneToMany
dip2ba 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta DIP2 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28B3.1 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 20 (a)
OneToMany
-- 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 36
  • 52 (a)
OneToMany
Species with no ortholog for DIP2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2B Gene

ENSEMBL:
Gene Tree for DIP2B (if available)
TreeFam:
Gene Tree for DIP2B (if available)

Paralogs for DIP2B Gene

Paralogs for DIP2B Gene

Selected SIMAP similar genes for DIP2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DIP2B: view

Variants for DIP2B Gene

Sequence variations from dbSNP and Humsavar for DIP2B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs726192 -- 50,746,935(-) TGGAC(A/G)GTGCA utr-variant-3-prime
rs876078 -- 50,636,052(+) GGAGA(G/T)ATGAC intron-variant
rs876079 -- 50,636,926(-) AAAAG(A/G)GGCCA intron-variant
rs876080 -- 50,636,981(-) CTCAC(C/T)GCCTA intron-variant
rs939631 -- 50,706,156(-) TTACT(A/G)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2B Gene

Variant ID Type Subtype PubMed ID
esv1512829 CNV Deletion 17803354
esv27734 CNV Loss 19812545
esv3400 CNV Deletion 18987735
dgv289n67 CNV Loss 20364138
esv2745873 CNV Deletion 23290073
esv2678706 CNV Deletion 23128226
esv9262 CNV Loss 19470904

Relevant External Links for DIP2B Gene

HapMap Linkage Disequilibrium report
DIP2B
Human Gene Mutation Database (HGMD)
DIP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2B Gene

Disorders for DIP2B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DIP2B Gene in MalaCards »

(1) Diseases for DIP2B Gene including...

(1) OMIM Diseases for DIP2B Gene (611379)

Relevant External Links for DIP2B

Genetic Association Database (GAD)
DIP2B
Human Genome Epidemiology (HuGE) Navigator
DIP2B
genes like me logo Genes that share disorders with DIP2B: view

No data available for UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DIP2B Gene

Publications for DIP2B Gene

  1. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33. (PMID: 20972440) Houlston R.S. … Tomlinson I.P. (Nat. Genet. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. (PMID: 17236128) Winnepenninckx B. … Kooy R.F. (Am. J. Hum. Genet. 2007) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for DIP2B Gene

Sources for DIP2B Gene

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