Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DIP2A Gene

Aliases for DIP2A Gene

  • Disco Interacting Protein 2 Homolog A 2 3 5
  • DIP2 Homolog A 3 4
  • C21orf106 3 4
  • DIP2 3 4
  • DIP2 Disco-Interacting Protein 2 Homolog A (Drosophila) 2
  • DIP2 Disco-Interacting Protein 2 Homolog A 3
  • Chromosome 21 Open Reading Frame 106 2
  • Disco-Interacting Protein 2A 3
  • KIAA0184 4

External Ids for DIP2A Gene

Previous HGNC Symbols for DIP2A Gene

  • C21orf106

Previous GeneCards Identifiers for DIP2A Gene

  • GC21P046704
  • GC21P047878
  • GC21P033258

Summaries for DIP2A Gene

Entrez Gene Summary for DIP2A Gene

  • The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for DIP2A Gene

DIP2A (Disco Interacting Protein 2 Homolog A) is a Protein Coding gene. Diseases associated with DIP2A include reading disorder. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2C.

UniProtKB/Swiss-Prot for DIP2A Gene

  • May provide positional cues for axon pathfinding and patterning in the central nervous system.

Gene Wiki entry for DIP2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2A Gene

Genomics for DIP2A Gene

Regulatory Elements for DIP2A Gene

Enhancers for DIP2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIP2A on UCSC Golden Path with GeneCards custom track

Promoters for DIP2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIP2A on UCSC Golden Path with GeneCards custom track

Genomic Location for DIP2A Gene

Chromosome:
21
Start:
46,458,899 bp from pter
End:
46,584,263 bp from pter
Size:
125,365 bases
Orientation:
Plus strand

Genomic View for DIP2A Gene

Genes around DIP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2A Gene

Proteins for DIP2A Gene

  • Protein details for DIP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14689-DIP2A_HUMAN
    Recommended name:
    Disco-interacting protein 2 homolog A
    Protein Accession:
    Q14689
    Secondary Accessions:
    • A6P4T3
    • B4E0F0
    • E7EMA5
    • Q8IVA3
    • Q8N4S2
    • Q8TD89
    • Q96ML9

    Protein attributes for DIP2A Gene

    Size:
    1571 amino acids
    Molecular mass:
    170369 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DIP2A Gene

neXtProt entry for DIP2A Gene

Proteomics data for DIP2A Gene at MOPED

Post-translational modifications for DIP2A Gene

  • Ubiquitination at Lys 558
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DIP2A Gene

Domains & Families for DIP2A Gene

Protein Domains for DIP2A Gene

Suggested Antigen Peptide Sequences for DIP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14689

UniProtKB/Swiss-Prot:

DIP2A_HUMAN :
  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
Domain:
  • Contains 1 DMAP-interaction domain.
Family:
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2A: view

No data available for Gene Families for DIP2A Gene

Function for DIP2A Gene

Molecular function for DIP2A Gene

UniProtKB/Swiss-Prot Function:
May provide positional cues for axon pathfinding and patterning in the central nervous system.
genes like me logo Genes that share phenotypes with DIP2A: view

miRNA for DIP2A Gene

miRTarBase miRNAs that target DIP2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIP2A Gene

Localization for DIP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIP2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIP2A Gene COMPARTMENTS Subcellular localization image for DIP2A gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DIP2A Gene

Pathways & Interactions for DIP2A Gene

SuperPathways for DIP2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIP2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DIP2A Gene

Drugs & Compounds for DIP2A Gene

No Compound Related Data Available

Transcripts for DIP2A Gene

Unigene Clusters for DIP2A Gene

DIP2 disco-interacting protein 2 homolog A (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b ^ 36a ·
SP1: - - - - - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11: -

ExUns: 36b · 36c ^ 37 ^ 38 ^ 39a · 39b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DIP2A Gene

GeneLoc Exon Structure for
DIP2A
ECgene alternative splicing isoforms for
DIP2A

Expression for DIP2A Gene

mRNA expression in normal human tissues for DIP2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DIP2A Gene

This gene is overexpressed in Retina (9.7), Placenta (9.0), Peripheral blood mononuclear cells (8.8), Prostate (8.0), and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIP2A Gene



SOURCE GeneReport for Unigene cluster for DIP2A Gene Hs.189585

mRNA Expression by UniProt/SwissProt for DIP2A Gene

Q14689-DIP2A_HUMAN
Tissue specificity: Low expression in all tissues tested.
genes like me logo Genes that share expression patterns with DIP2A: view

Protein tissue co-expression partners for DIP2A Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DIP2A Gene

Orthologs for DIP2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DIP2A 35
  • 86.56 (n)
  • 91.36 (a)
DIP2A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DIP2A 35
  • 88.46 (n)
  • 94.07 (a)
mouse
(Mus musculus)
Mammalia Dip2a 35
  • 87 (n)
  • 93.41 (a)
Dip2a 16
Dip2a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DIP2A 35
  • 99.43 (n)
  • 99.75 (a)
DIP2A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dip2a 35
  • 86.7 (n)
  • 93.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DIP2A 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIP2A 35
  • 77.74 (n)
  • 89.33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2a 35
  • 74.34 (n)
  • 84.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8867 35
zebrafish
(Danio rerio)
Actinopterygii dip2a 35
  • 75.28 (n)
  • 83.89 (a)
dip2a 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DIP2 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28B3.1 36
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 36
  • 54 (a)
OneToMany
Species with no ortholog for DIP2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2A Gene

ENSEMBL:
Gene Tree for DIP2A (if available)
TreeFam:
Gene Tree for DIP2A (if available)

Paralogs for DIP2A Gene

Paralogs for DIP2A Gene

(4) SIMAP similar genes for DIP2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DIP2A: view

Variants for DIP2A Gene

Sequence variations from dbSNP and Humsavar for DIP2A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs7283507 - 46,498,749(+) GGAGA(C/G)CCACC intron-variant, reference, missense
rs16979312 - 46,529,104(+) TTGGA(A/G)TCGGA reference, missense
rs1107065 -- 46,554,669(+) ACCAC(A/G)CTGCC reference, synonymous-codon
rs2255397 -- 46,550,668(+) GGGAC(A/G)CTGCA reference, synonymous-codon
rs2255526 -- 46,551,626(+) CCCCC(A/G)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2A Gene

Variant ID Type Subtype PubMed ID
nsv470910 CNV Gain 18288195
nsv519904 CNV Loss 19592680
dgv4817n71 CNV Loss 21882294
nsv459312 CNV Gain 19166990
nsv3548 CNV Insertion 18451855
nsv914147 CNV Loss 21882294
nsv459313 CNV Loss 19166990
nsv914148 CNV Loss 21882294
nsv523038 CNV Loss 19592680
nsv526768 CNV Loss 19592680
nsv528947 CNV Gain 19592680
dgv1375e1 CNV Complex 17122850

Variation tolerance for DIP2A Gene

Residual Variation Intolerance Score: 2.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIP2A Gene

HapMap Linkage Disequilibrium report
DIP2A
Human Gene Mutation Database (HGMD)
DIP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2A Gene

Disorders for DIP2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for DIP2A Gene - From: DISEASES

Disorder Aliases PubMed IDs
reading disorder
  • specific reading disorder
- elite association - COSMIC cancer census association via MalaCards
Search DIP2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIP2A

Genetic Association Database (GAD)
DIP2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIP2A
genes like me logo Genes that share disorders with DIP2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIP2A Gene

Publications for DIP2A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for DIP2A Gene

Sources for DIP2A Gene

Content