Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DIP2A Gene

Aliases for DIP2A Gene

  • DIP2 Disco-Interacting Protein 2 Homolog A (Drosophila) 2 3
  • DIP2 3 4 6
  • DIP2 Homolog A 3 4
  • C21orf106 3 4
  • KIAA0184 4 6
  • Disco-Interacting Protein 2 Homolog A 3
  • Chromosome 21 Open Reading Frame 106 2
  • Disco-Interacting Protein 2A 3

External Ids for DIP2A Gene

Previous HGNC Symbols for DIP2A Gene

  • C21orf106

Previous GeneCards Identifiers for DIP2A Gene

  • GC21P046704
  • GC21P047878
  • GC21P033258

Summaries for DIP2A Gene

Entrez Gene Summary for DIP2A Gene

  • The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for DIP2A Gene

DIP2A (DIP2 Disco-Interacting Protein 2 Homolog A (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2C.

UniProtKB/Swiss-Prot for DIP2A Gene

  • May provide positional cues for axon pathfinding and patterning in the central nervous system

Gene Wiki entry for DIP2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2A Gene

Genomics for DIP2A Gene

Regulatory Elements for DIP2A Gene

Genomic Location for DIP2A Gene

Start:
46,458,899 bp from pter
End:
46,570,013 bp from pter
Size:
111,115 bases
Orientation:
Plus strand

Genomic View for DIP2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2A Gene

Proteins for DIP2A Gene

  • Protein details for DIP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14689-DIP2A_HUMAN
    Recommended name:
    Disco-interacting protein 2 homolog A
    Protein Accession:
    Q14689
    Secondary Accessions:
    • A6P4T3
    • B4E0F0
    • E7EMA5
    • Q8IVA3
    • Q8N4S2
    • Q8TD89
    • Q96ML9

    Protein attributes for DIP2A Gene

    Size:
    1571 amino acids
    Molecular mass:
    170369 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DIP2A Gene

neXtProt entry for DIP2A Gene

Proteomics data for DIP2A Gene at MOPED

Post-translational modifications for DIP2A Gene

  • Ubiquitination at Lys558 and Lys1296
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DIP2A Gene

Domains for DIP2A Gene

Protein Domains for DIP2A Gene

Suggested Antigen Peptide Sequences for DIP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14689

UniProtKB/Swiss-Prot:

DIP2A_HUMAN :
  • Q14689
Domain:
  • Contains 1 DMAP-interaction domain.
Family:
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2A: view

No data available for Gene Families for DIP2A Gene

Function for DIP2A Gene

Molecular function for DIP2A Gene

UniProtKB/Swiss-Prot Function: May provide positional cues for axon pathfinding and patterning in the central nervous system

Gene Ontology (GO) - Molecular Function for DIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 20054002
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with DIP2A: view

Animal Model Products

CRISPR Products

miRNA for DIP2A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DIP2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DIP2A Gene

Localization for DIP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIP2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIP2A Gene COMPARTMENTS Subcellular localization image for DIP2A gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0009986 cell surface IDA 20054002
genes like me logo Genes that share ontologies with DIP2A: view

Pathways for DIP2A Gene

SuperPathways for DIP2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0008152 metabolic process IEA --
GO:0010629 negative regulation of gene expression IDA 20860622
GO:0042981 regulation of apoptotic process IMP 20054002
genes like me logo Genes that share ontologies with DIP2A: view

No data available for Pathways by source for DIP2A Gene

Transcripts for DIP2A Gene

Unigene Clusters for DIP2A Gene

DIP2 disco-interacting protein 2 homolog A (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DIP2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DIP2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b ^ 36a ·
SP1: - - - - - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11: -

ExUns: 36b · 36c ^ 37 ^ 38 ^ 39a · 39b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DIP2A Gene

GeneLoc Exon Structure for
DIP2A
ECgene alternative splicing isoforms for
DIP2A

Expression for DIP2A Gene

mRNA expression in normal human tissues for DIP2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIP2A Gene

SOURCE GeneReport for Unigene cluster for DIP2A Gene Hs.189585

mRNA Expression by UniProt/SwissProt for DIP2A Gene

Q14689-DIP2A_HUMAN
Tissue specificity: Low expression in all tissues tested
genes like me logo Genes that share expressions with DIP2A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DIP2A Gene

Orthologs for DIP2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIP2A 35
  • 99.43 (n)
  • 99.75 (a)
DIP2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DIP2A 35
  • 86.56 (n)
  • 91.36 (a)
DIP2A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DIP2A 35
  • 88.46 (n)
  • 94.07 (a)
mouse
(Mus musculus)
Mammalia Dip2a 35
  • 87 (n)
  • 93.41 (a)
Dip2a 16
Dip2a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DIP2A 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dip2a 35
  • 86.7 (n)
  • 93.02 (a)
chicken
(Gallus gallus)
Aves DIP2A 35
  • 77.74 (n)
  • 89.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8867 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2a 35
  • 74.34 (n)
  • 84.44 (a)
zebrafish
(Danio rerio)
Actinopterygii dip2a 35
  • 75.28 (n)
  • 83.89 (a)
dip2a 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DIP2 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28B3.1 36
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 36
  • 54 (a)
OneToMany
Species with no ortholog for DIP2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2A Gene

ENSEMBL:
Gene Tree for DIP2A (if available)
TreeFam:
Gene Tree for DIP2A (if available)

Paralogs for DIP2A Gene

Paralogs for DIP2A Gene

Selected SIMAP similar genes for DIP2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DIP2A: view

Variants for DIP2A Gene

Sequence variations from dbSNP and Humsavar for DIP2A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs718496 -- 46,484,672(-) AAAAC(G/T)GGAAA intron-variant
rs721131 -- 46,537,854(+) ACAGT(C/T)GGCAG intron-variant
rs725969 -- 46,544,756(-) AGCCC(A/G)GGACA intron-variant
rs725970 -- 46,544,730(-) GAGCC(G/T)GACAG intron-variant
rs743349 -- 46,563,176(+) TCTGG(C/T)GGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2A Gene

Variant ID Type Subtype PubMed ID
nsv470910 CNV Gain 18288195
nsv519904 CNV Loss 19592680
dgv4817n71 CNV Loss 21882294
nsv459312 CNV Gain 19166990
nsv3548 CNV Insertion 18451855
nsv914147 CNV Loss 21882294
nsv459313 CNV Loss 19166990
nsv914148 CNV Loss 21882294
nsv523038 CNV Loss 19592680
nsv526768 CNV Loss 19592680
nsv528947 CNV Gain 19592680
dgv1375e1 CNV Complex 17122850

Relevant External Links for DIP2A Gene

HapMap Linkage Disequilibrium report
DIP2A
Human Gene Mutation Database (HGMD)
DIP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2A Gene

Disorders for DIP2A Gene

(1) University of Copenhagen DISEASES for DIP2A Gene

Relevant External Links for DIP2A

Genetic Association Database (GAD)
DIP2A
genes like me logo Genes that share disorders with DIP2A: view

No data available for UniProtKB/Swiss-Prot for DIP2A Gene

Publications for DIP2A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 3 4
  4. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  5. Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins. (PMID: 11675124) Yu G. … Rubenstein J.L. (Brain Res. Dev. Brain Res. 2001) 3

Products for DIP2A Gene

Sources for DIP2A Gene

Back to Top

Content