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Aliases for DIP2A Gene

Aliases for DIP2A Gene

  • Disco Interacting Protein 2 Homolog A 2 3 5
  • DIP2 Homolog A 3 4
  • C21orf106 3 4
  • DIP2 3 4
  • DIP2 Disco-Interacting Protein 2 Homolog A (Drosophila) 2
  • DIP2 Disco-Interacting Protein 2 Homolog A 3
  • Disco-Interacting Protein 2 Homolog A 3
  • Chromosome 21 Open Reading Frame 106 2
  • Disco-Interacting Protein 2A 3
  • KIAA0184 4

External Ids for DIP2A Gene

Previous HGNC Symbols for DIP2A Gene

  • C21orf106

Previous GeneCards Identifiers for DIP2A Gene

  • GC21P046704
  • GC21P047878
  • GC21P033258

Summaries for DIP2A Gene

Entrez Gene Summary for DIP2A Gene

  • The protein encoded by this gene may be involved in axon patterning in the central nervous system. This gene is not highly expressed. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for DIP2A Gene

DIP2A (Disco Interacting Protein 2 Homolog A) is a Protein Coding gene. Diseases associated with DIP2A include Dyslexia and Reading Disorder. GO annotations related to this gene include transcription factor binding. An important paralog of this gene is DIP2C.

UniProtKB/Swiss-Prot for DIP2A Gene

  • May provide positional cues for axon pathfinding and patterning in the central nervous system.

Gene Wiki entry for DIP2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIP2A Gene

Genomics for DIP2A Gene

Regulatory Elements for DIP2A Gene

Enhancers for DIP2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F046514 0.8 Ensembl ENCODE 28 +56.4 56445 1.3 ZNF362 RAD21 SPI1 TRIM28 ZNF558 DIP2A DIP2A-IT1 MCM3AP-AS1 MCM3AP S100B RNU6-396P
GH21F046454 1.1 ENCODE 19.3 -1.4 -1431 6.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DIP2A ENSG00000228235 MCM3AP SPATC1L PRMT2 MCM3AP-AS1 S100B YBEY GC21M046471 RPL18AP2
GH21F046293 1.2 Ensembl ENCODE 10.4 -163.1 -163122 5.3 PKNOX1 ARID4B DMAP1 GLIS2 SP3 NFYC MXD4 KAT8 SMARCA4 PBX2 YBEY MCM3AP MCM3AP-AS1 ENSG00000228137 SPATC1L DIP2A S100B GC21P046292 GC21P046294 C21orf58
GH21F046499 1 Ensembl ENCODE 11.8 +42.1 42123 2.1 BCOR ELF3 LEF1 SAP130 ETV1 BACH1 ZNF316 GATA3 NFE2 FOS MCM3AP DIP2A-IT1 DIP2A PRMT2 RNU6-396P
GH21F046604 1 Ensembl ENCODE 11.3 +147.1 147102 2.4 PKNOX1 MAX ZFHX2 EED PRDM10 ZNF600 ZNF652 EGR2 GFI1B SP2 S100B DIP2A SPATC1L PRMT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DIP2A on UCSC Golden Path with GeneCards custom track

Promoters for DIP2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000615079 201 3001 HDGF CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for DIP2A Gene

Chromosome:
21
Start:
46,458,899 bp from pter
End:
46,584,263 bp from pter
Size:
125,365 bases
Orientation:
Plus strand

Genomic View for DIP2A Gene

Genes around DIP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIP2A Gene

Proteins for DIP2A Gene

  • Protein details for DIP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14689-DIP2A_HUMAN
    Recommended name:
    Disco-interacting protein 2 homolog A
    Protein Accession:
    Q14689
    Secondary Accessions:
    • A6P4T3
    • B4E0F0
    • E7EMA5
    • Q8IVA3
    • Q8N4S2
    • Q8TD89
    • Q96ML9

    Protein attributes for DIP2A Gene

    Size:
    1571 amino acids
    Molecular mass:
    170369 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DIP2A Gene

neXtProt entry for DIP2A Gene

Post-translational modifications for DIP2A Gene

  • Ubiquitination at Lys 558
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DIP2A
  • Santa Cruz Biotechnology (SCBT) Antibodies for DIP2A

No data available for DME Specific Peptides for DIP2A Gene

Domains & Families for DIP2A Gene

Protein Domains for DIP2A Gene

Suggested Antigen Peptide Sequences for DIP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14689

UniProtKB/Swiss-Prot:

DIP2A_HUMAN :
  • Contains 1 DMAP-interaction domain.
  • Belongs to the DIP2 family.
Domain:
  • Contains 1 DMAP-interaction domain.
Family:
  • Belongs to the DIP2 family.
genes like me logo Genes that share domains with DIP2A: view

No data available for Gene Families for DIP2A Gene

Function for DIP2A Gene

Molecular function for DIP2A Gene

UniProtKB/Swiss-Prot Function:
May provide positional cues for axon pathfinding and patterning in the central nervous system.

Gene Ontology (GO) - Molecular Function for DIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 20054002
genes like me logo Genes that share ontologies with DIP2A: view
genes like me logo Genes that share phenotypes with DIP2A: view

Animal Model Products

miRNA for DIP2A Gene

miRTarBase miRNAs that target DIP2A

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIP2A Gene

Localization for DIP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIP2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DIP2A gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0009986 cell surface IDA 20054002
genes like me logo Genes that share ontologies with DIP2A: view

Pathways & Interactions for DIP2A Gene

SuperPathways for DIP2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0008152 metabolic process IEA --
GO:0010629 negative regulation of gene expression IDA 20860622
GO:0042981 regulation of apoptotic process IMP 20054002
genes like me logo Genes that share ontologies with DIP2A: view

No data available for Pathways by source and SIGNOR curated interactions for DIP2A Gene

Transcripts for DIP2A Gene

Unigene Clusters for DIP2A Gene

DIP2 disco-interacting protein 2 homolog A (Drosophila):
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIP2A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b ^ 36a ·
SP1: - - - - - - - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11: -

ExUns: 36b · 36c ^ 37 ^ 38 ^ 39a · 39b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DIP2A Gene

GeneLoc Exon Structure for
DIP2A
ECgene alternative splicing isoforms for
DIP2A

Expression for DIP2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DIP2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DIP2A Gene

This gene is overexpressed in Retina (9.7), Placenta (9.0), Peripheral blood mononuclear cells (8.8), Prostate (8.0), and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIP2A Gene



Protein tissue co-expression partners for DIP2A Gene

NURSA nuclear receptor signaling pathways regulating expression of DIP2A Gene:

DIP2A

SOURCE GeneReport for Unigene cluster for DIP2A Gene:

Hs.189585

mRNA Expression by UniProt/SwissProt for DIP2A Gene:

Q14689-DIP2A_HUMAN
Tissue specificity: Low expression in all tissues tested.
genes like me logo Genes that share expression patterns with DIP2A: view

Primer Products

No data available for mRNA differential expression in normal tissues for DIP2A Gene

Orthologs for DIP2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DIP2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIP2A 34 35
  • 99.43 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DIP2A 34
  • 88.46 (n)
mouse
(Mus musculus)
Mammalia Dip2a 34 16 35
  • 87 (n)
rat
(Rattus norvegicus)
Mammalia Dip2a 34
  • 86.7 (n)
cow
(Bos Taurus)
Mammalia DIP2A 34 35
  • 86.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DIP2A 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIP2A 34
  • 77.74 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia dip2a 34
  • 74.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8867 34
zebrafish
(Danio rerio)
Actinopterygii dip2a 34 35
  • 75.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta DIP2 35
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F28B3.1 35
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.49 35
  • 54 (a)
OneToMany
Species where no ortholog for DIP2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIP2A Gene

ENSEMBL:
Gene Tree for DIP2A (if available)
TreeFam:
Gene Tree for DIP2A (if available)

Paralogs for DIP2A Gene

Paralogs for DIP2A Gene

(4) SIMAP similar genes for DIP2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DIP2A: view

Variants for DIP2A Gene

Sequence variations from dbSNP and Humsavar for DIP2A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs768627699 Likely benign 46,549,902(+) GGCAC(A/G)GCCTA intron-variant, reference, missense, utr-variant-3-prime
rs1007893 -- 46,457,681(+) ATATG(C/T)AACGG upstream-variant-2KB
rs1008548 -- 46,539,779(+) GTTCC(A/G)ATGGC intron-variant
rs1008549 -- 46,539,785(+) ATGGC(C/T)GCAGG intron-variant
rs1023355 -- 46,472,893(+) tttct(G/T)ctacg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIP2A Gene

Variant ID Type Subtype PubMed ID
nsv587999 CNV gain 21841781
nsv587998 CNV gain 21841781
nsv528947 CNV gain 19592680
nsv526768 CNV loss 19592680
nsv523038 CNV loss 19592680
nsv519904 CNV loss 19592680
nsv470910 CNV gain 18288195
nsv459313 CNV loss 19166990
nsv459312 CNV gain 19166990
nsv3548 CNV insertion 18451855
nsv1073142 CNV deletion 25765185
nsv1065227 CNV gain 25217958
nsv1057566 CNV loss 25217958
esv3647170 CNV gain 21293372
esv3647169 CNV loss 21293372
esv2762115 CNV loss 21179565
esv2760700 CNV gain 21179565
esv2758822 CNV gain 17122850
dgv7933n54 CNV loss 21841781
dgv4443n100 CNV gain 25217958
dgv4442n100 CNV gain 25217958
dgv4441n100 CNV gain 25217958

Variation tolerance for DIP2A Gene

Residual Variation Intolerance Score: 2.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIP2A Gene

Human Gene Mutation Database (HGMD)
DIP2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIP2A Gene

Disorders for DIP2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for DIP2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dyslexia
reading disorder
  • dyslexia
- elite association - COSMIC cancer census association via MalaCards
Search DIP2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIP2A

Genetic Association Database (GAD)
DIP2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIP2A
genes like me logo Genes that share disorders with DIP2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIP2A Gene

Publications for DIP2A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for DIP2A Gene

Sources for DIP2A Gene

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