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Aliases for DIO3OS Gene

Subcategory (RNA class) for DIO3OS Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for DIO3OS Gene

  • DIO3 Opposite Strand/Antisense RNA (Head To Head) 2 3 5
  • Deiodinase, Iodothyronine, Type III Opposite Strand 2 3
  • DIO3 Opposite Strand/Antisense RNA (Non-Protein Coding) 3
  • DIO3 Opposite Strand (Non-Protein Coding) 3
  • Chromosome 14 Open Reading Frame 134 2
  • DIO3 Opposite Strand/Antisense RNA 2
  • Uterine-Derived 14 KDa Protein 3
  • Non-Protein Coding RNA 41 2
  • NCRNA00041 3
  • C14orf134 3
  • DIO3-AS1 3
  • DIO3-OS 3

External Ids for DIO3OS Gene

Previous HGNC Symbols for DIO3OS Gene

  • C14orf134

Previous GeneCards Identifiers for DIO3OS Gene

  • GC14M100013
  • GC14U900485
  • GC14M101088
  • GC14M102018

Summaries for DIO3OS Gene

Entrez Gene Summary for DIO3OS Gene

  • The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DIO3OS Gene

DIO3OS (DIO3 Opposite Strand/Antisense RNA (Head To Head)) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for DIO3OS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIO3OS Gene

Genomics for DIO3OS Gene

Regulatory Elements for DIO3OS Gene

Enhancers for DIO3OS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H100616 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 +942.5 942454 2 PKNOX1 ELF1 RARA GABPA NFIL3 GATA3 ZNF366 ZBTB48 HNF4A CUX1 BEGAIN DIO3 DIO3OS DLK1 ENSG00000258576 PIR56329
GH14H101555 0.8 ENCODE 18.8 +4.8 4785 0.9 HDGF FOXA2 ZNF473 ZSCAN4 BMI1 RAD21 ZNF207 MCM3 ZIK1 MXD4 ZNF839 DYNC1H1 WDR20 DIO3OS MEG8 ENSG00000272444 BEGAIN ENSG00000258959 MIR1247 LOC105370674
GH14H101462 0.7 ENCODE 10 +97.3 97301 1 ZNF473 ZNF571 ZSCAN4 USF2 BMI1 ZNF311 CTBP1 ZNF776 ZNF692 POLR2A WDR20 ENSG00000258959 ZNF839 MEG9 RPL26P4 DIO3OS MOK LOC105370672 GC14P103090
GH14H101541 0.4 ENCODE 10.4 +17.9 17918 1.6 ZNF16 WDR20 DIO3OS LOC105370673 GC14P103098
GH14H101623 0.4 FANTOM5 10.3 -63.1 -63124 0.1 ZNF16 DIO3 MIR1247 WDR20 DIO3OS ENSG00000258919 LOC105370675
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DIO3OS on UCSC Golden Path with GeneCards custom track

Genomic Locations for DIO3OS Gene

Genomic Locations for DIO3OS Gene
8,211 bases
Minus strand

Genomic View for DIO3OS Gene

Genes around DIO3OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIO3OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIO3OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIO3OS Gene

Proteins for DIO3OS Gene

Post-translational modifications for DIO3OS Gene

No Post-translational modifications

No data available for DME Specific Peptides for DIO3OS Gene

Domains & Families for DIO3OS Gene

Gene Families for DIO3OS Gene

Suggested Antigen Peptide Sequences for DIO3OS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DIO3OS: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for DIO3OS Gene

Function for DIO3OS Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DIO3OS Gene

Localization for DIO3OS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DIO3OS Gene

Pathways & Interactions for DIO3OS Gene

SuperPathways for DIO3OS Gene

No Data Available

Interacting Proteins for DIO3OS Gene

Gene Ontology (GO) - Biological Process for DIO3OS Gene


No data available for Pathways by source and SIGNOR curated interactions for DIO3OS Gene

Drugs & Compounds for DIO3OS Gene

No Compound Related Data Available

Transcripts for DIO3OS Gene

mRNA/cDNA for DIO3OS Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIO3OS Gene

No ASD Table

Relevant External Links for DIO3OS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIO3OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DIO3OS Gene

mRNA differential expression in normal tissues according to GTEx for DIO3OS Gene

This gene is overexpressed in Ovary (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of DIO3OS Gene:


SOURCE GeneReport for Unigene cluster for DIO3OS Gene:

genes like me logo Genes that share expression patterns with DIO3OS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DIO3OS Gene

Orthologs for DIO3OS Gene

Evolution for DIO3OS Gene

Gene Tree for DIO3OS (if available)
Gene Tree for DIO3OS (if available)

No data available for Orthologs for DIO3OS Gene

Paralogs for DIO3OS Gene

No data available for Paralogs for DIO3OS Gene

Variants for DIO3OS Gene

Sequence variations from dbSNP and Humsavar for DIO3OS Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000431253 -- 101,555,773(+) ACACA(C/G)ACATA upstream-variant-2KB
rs1000843938 -- 101,554,949(+) GGCCC(C/T)ACTTA nc-transcript-variant
rs1000863834 -- 101,555,886(+) CACAT(A/G)CACAC upstream-variant-2KB
rs1001276984 -- 101,553,072(+) AACAA(C/T)GGCCA nc-transcript-variant
rs1001338378 -- 101,555,134(+) CAAAC(A/G)GTCCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DIO3OS Gene

Variant ID Type Subtype PubMed ID
nsv952247 CNV deletion 24416366
nsv565880 CNV loss 21841781
nsv565879 CNV loss 21841781
nsv1047869 CNV gain 25217958
esv3635528 CNV gain 21293372
dgv1978n100 CNV gain 25217958
dgv1977n100 CNV gain 25217958

Relevant External Links for DIO3OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DIO3OS Gene

Disorders for DIO3OS Gene

Relevant External Links for DIO3OS

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIO3OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIO3OS Gene

Publications for DIO3OS Gene

  1. Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus. (PMID: 14962667) Hernandez A … St Germain DL (Genomics 2004) 2 3 22 60
  2. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PMID: 23192594) Velez Edwards DR … Edwards TL (Human genetics 2013) 3 60
  3. Regulation of type III iodothyronine deiodinase expression in human cell lines. (PMID: 16935842) Kester MH … Visser TJ (Endocrinology 2006) 22 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for DIO3OS Gene

Sources for DIO3OS Gene

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