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Aliases for DIO3OS Gene

Subcategory (RNA class) for DIO3OS Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for DIO3OS Gene

  • DIO3 Opposite Strand/Antisense RNA (Head To Head) 2 3 5
  • Deiodinase, Iodothyronine, Type III Opposite Strand 2 3
  • DIO3 Opposite Strand/Antisense RNA (Non-Protein Coding) 3
  • DIO3 Opposite Strand (Non-Protein Coding) 3
  • Chromosome 14 Open Reading Frame 134 2
  • DIO3 Opposite Strand/Antisense RNA 2
  • Uterine-Derived 14 KDa Protein 3
  • Non-Protein Coding RNA 41 2
  • NCRNA00041 3
  • C14orf134 3
  • DIO3-AS1 3
  • DIO3-OS 3

External Ids for DIO3OS Gene

Previous HGNC Symbols for DIO3OS Gene

  • C14orf134

Previous GeneCards Identifiers for DIO3OS Gene

  • GC14M100013
  • GC14U900485
  • GC14M101088
  • GC14M102018

Summaries for DIO3OS Gene

Entrez Gene Summary for DIO3OS Gene

  • The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DIO3OS Gene

DIO3OS (DIO3 Opposite Strand/Antisense RNA (Head To Head)) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIO3OS Gene

Genomics for DIO3OS Gene

Regulatory Elements for DIO3OS Gene

Enhancers for DIO3OS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F102522 1.8 FANTOM5 Ensembl ENCODE 11 -965.7 -965663 6.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RCOR1 TECPR2 RPL23AP11 MOK ANKRD9 TRAF3 DIO3 ENSG00000271780 RNU6-244P DIO3OS
GH14F101961 1.3 Ensembl ENCODE 13 -404.5 -404458 6.0 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS ZNF263 SP3 HSP90AA1 DIO3OS PPP2R5C WDR20 ZNF839 DYNC1H1 ENSG00000259013
GH14F101947 1.2 ENCODE 13 -388.1 -388065 2.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000271780 DIO3OS GC14M101945
GH14F100616 1.3 FANTOM5 Ensembl ENCODE 11 +942.2 942231 2.8 CTCF PKNOX1 ZNF2 RAD21 RARA ZFHX2 GATA3 ZBTB48 ZNF366 EGR2 BEGAIN DIO3 DIO3OS WARS WDR25 DLK1 ENSG00000258576 PIR56329
GH14F102046 0.9 ENCODE 11 -486.2 -486154 1.0 PKNOX1 ZNF133 KLF17 ARID4B SIN3A RAD21 ZNF121 GLIS2 KLF7 CREM DIO3 DIO3OS DYNC1H1 ENSG00000258959 ENSG00000259013
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DIO3OS on UCSC Golden Path with GeneCards custom track

Promoters for DIO3OS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001792509 -269 601 CTCF CBX2 RAD21

Genomic Location for DIO3OS Gene

101,552,221 bp from pter
101,560,431 bp from pter
8,211 bases
Minus strand

Genomic View for DIO3OS Gene

Genes around DIO3OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIO3OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIO3OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIO3OS Gene

Proteins for DIO3OS Gene

Post-translational modifications for DIO3OS Gene

No Post-translational modifications

No data available for DME Specific Peptides for DIO3OS Gene

Domains & Families for DIO3OS Gene

Gene Families for DIO3OS Gene

Suggested Antigen Peptide Sequences for DIO3OS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DIO3OS: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for DIO3OS Gene

Function for DIO3OS Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DIO3OS Gene

Localization for DIO3OS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DIO3OS Gene

Pathways & Interactions for DIO3OS Gene

SuperPathways for DIO3OS Gene

No Data Available

Interacting Proteins for DIO3OS Gene

Gene Ontology (GO) - Biological Process for DIO3OS Gene


No data available for Pathways by source and SIGNOR curated interactions for DIO3OS Gene

Transcripts for DIO3OS Gene

mRNA/cDNA for DIO3OS Gene

(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DIO3OS Gene

No ASD Table

Relevant External Links for DIO3OS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIO3OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DIO3OS Gene

mRNA differential expression in normal tissues according to GTEx for DIO3OS Gene

This gene is overexpressed in Ovary (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of DIO3OS Gene:


SOURCE GeneReport for Unigene cluster for DIO3OS Gene:

genes like me logo Genes that share expression patterns with DIO3OS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DIO3OS Gene

Orthologs for DIO3OS Gene

Evolution for DIO3OS Gene

Gene Tree for DIO3OS (if available)
Gene Tree for DIO3OS (if available)

No data available for Orthologs for DIO3OS Gene

Paralogs for DIO3OS Gene

No data available for Paralogs for DIO3OS Gene

Variants for DIO3OS Gene

Sequence variations from dbSNP and Humsavar for DIO3OS Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1048440 -- 101,552,488(-) TGTGG(C/T)TCCAG nc-transcript-variant
rs111257844 -- 101,555,662(+) GAGGA(A/G)TCCTG nc-transcript-variant
rs111429072 -- 101,551,820(+) GCACC(C/T)GGATG downstream-variant-500B
rs111663757 -- 101,556,381(+) GCTGC(C/G)GCAGG upstream-variant-2KB
rs112569094 -- 101,553,024(+) CACAG(A/C)CCAAG nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DIO3OS Gene

Variant ID Type Subtype PubMed ID
nsv952247 CNV deletion 24416366
nsv565880 CNV loss 21841781
nsv565879 CNV loss 21841781
nsv1047869 CNV gain 25217958
esv3635528 CNV gain 21293372
dgv1978n100 CNV gain 25217958
dgv1977n100 CNV gain 25217958

Relevant External Links for DIO3OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DIO3OS Gene

Disorders for DIO3OS Gene

Relevant External Links for DIO3OS

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIO3OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIO3OS Gene

Publications for DIO3OS Gene

  1. Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus. (PMID: 14962667) Hernandez A. … St Germain D.L. (Genomics 2004) 2 3 22 64
  2. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PMID: 23192594) Velez Edwards D.R. … Edwards T.L. (Hum. Genet. 2013) 3 64
  3. Regulation of type III iodothyronine deiodinase expression in human cell lines. (PMID: 16935842) Kester M.H. … Visser T.J. (Endocrinology 2006) 22 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for DIO3OS Gene

Sources for DIO3OS Gene

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