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Aliases for DIO3OS Gene

Subcategory (RNA class) for DIO3OS Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for DIO3OS Gene

  • DIO3 Opposite Strand/Antisense RNA (Head To Head) 2 3
  • Deiodinase, Iodothyronine, Type III Opposite Strand 2 3
  • DIO3 Opposite Strand/Antisense RNA (Non-Protein Coding) 3
  • DIO3 Opposite Strand (Non-Protein Coding) 3
  • Chromosome 14 Open Reading Frame 134 2
  • DIO3 Opposite Strand/Antisense RNA 2
  • Uterine-Derived 14 KDa Protein 3
  • Non-Protein Coding RNA 41 2
  • NCRNA00041 3
  • C14orf134 3
  • DIO3-AS1 3
  • DIO3-OS 3

External Ids for DIO3OS Gene

Previous HGNC Symbols for DIO3OS Gene

  • C14orf134

Previous GeneCards Identifiers for DIO3OS Gene

  • GC14M100013
  • GC14U900485
  • GC14M101088
  • GC14M102018

Summaries for DIO3OS Gene

Entrez Gene Summary for DIO3OS Gene

  • The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DIO3OS Gene

DIO3OS (DIO3 Opposite Strand/Antisense RNA (Head To Head)) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIO3OS Gene

Genomics for DIO3OS Gene

Regulatory Elements for DIO3OS Gene

Genomic Location for DIO3OS Gene

101,552,221 bp from pter
101,560,431 bp from pter
8,211 bases
Minus strand

Genomic View for DIO3OS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DIO3OS Gene

Proteins for DIO3OS Gene

Post-translational modifications for DIO3OS Gene

No Post-translational modifications

No data available for DME Specific Peptides for DIO3OS Gene

Domains & Families for DIO3OS Gene

Gene Families for DIO3OS Gene

Suggested Antigen Peptide Sequences for DIO3OS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DIO3OS: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for DIO3OS Gene

Function for DIO3OS Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DIO3OS Gene

Localization for DIO3OS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DIO3OS Gene

Pathways & Interactions for DIO3OS Gene

SuperPathways for DIO3OS Gene

No Data Available

Interacting Proteins for DIO3OS Gene

Gene Ontology (GO) - Biological Process for DIO3OS Gene


No data available for Pathways by source and SIGNOR curated interactions for DIO3OS Gene

Drugs & Compounds for DIO3OS Gene

No Compound Related Data Available

Transcripts for DIO3OS Gene

mRNA/cDNA for DIO3OS Gene

(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DIO3OS Gene

No ASD Table

Relevant External Links for DIO3OS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIO3OS Gene

mRNA expression in normal human tissues for DIO3OS Gene

mRNA differential expression in normal tissues according to GTEx for DIO3OS Gene

This gene is overexpressed in Ovary (x6.7).

SOURCE GeneReport for Unigene cluster for DIO3OS Gene Hs.525597

genes like me logo Genes that share expression patterns with DIO3OS: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DIO3OS Gene

Orthologs for DIO3OS Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for DIO3OS Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Dio3os 16
Species with no ortholog for DIO3OS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DIO3OS Gene

Gene Tree for DIO3OS (if available)
Gene Tree for DIO3OS (if available)

Paralogs for DIO3OS Gene

No data available for Paralogs for DIO3OS Gene

Variants for DIO3OS Gene

Sequence variations from dbSNP and Humsavar for DIO3OS Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1048440 -- 101,552,488(-) TGTGG(C/T)TCCAG nc-transcript-variant
rs1190715 -- 101,556,742(-) AGCAG(A/G)GGTGT upstream-variant-2KB
rs12147061 -- 101,552,820(+) TCCAT(A/C)TCCGA nc-transcript-variant
rs12147069 -- 101,552,841(+) AAACC(A/C)ATAAG nc-transcript-variant
rs17100344 -- 101,552,609(+) AACGA(A/G)GAGCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DIO3OS Gene

Variant ID Type Subtype PubMed ID
nsv902251 CNV Loss 21882294
nsv902252 CNV Loss 21882294
nsv902253 CNV Loss 21882294

Relevant External Links for DIO3OS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DIO3OS Gene

Disorders for DIO3OS Gene

Relevant External Links for DIO3OS

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DIO3OS: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIO3OS Gene

Publications for DIO3OS Gene

  1. Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus. (PMID: 14962667) Hernandez A. … St Germain D.L. (Genomics 2004) 2 23 67
  2. Regulation of type III iodothyronine deiodinase expression in human cell lines. (PMID: 16935842) Kester M.H. … Visser T.J. (Endocrinology 2006) 23 67
  3. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. (PMID: 23192594) Velez Edwards D.R. … Edwards T.L. (Hum. Genet. 2013) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for DIO3OS Gene

Sources for DIO3OS Gene

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