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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DIO3 Gene

protein-coding GIFtS: 54
GCID: GC14P102027

deiodinase, iodothyronine, type III

(Previous symbol: TXDI3)

Explore 23 diseases affiliated with
DIO3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Deiodinase, Iodothyronine, Type III¹ ²		Iodothyronine Deiodinase, Placental Type²
TXDI3¹ ² ³ ⁵		Thyroxine Deiodinase Type III (Selenoprotein)²
Type 3 DI² ³		Type 3 Iodothyronine Selenodeiodinase²
Type-III 5'-Deiodinase² ³		Type III Iodothyronine Deiodinase²
5DIII² ³		Type-III 5' Deiodinase²
DIOIII² ³		ITDI3³
EC 1.97.1.11³ ⁸		EC 1.97.1⁸
D3²

External Ids:	HGNC: 2885¹	Entrez Gene: 1735²	Ensembl: ENSG00000258865⁷	OMIM: 601038⁵	UniProtKB: P55073³

Export aliases for DIO3 gene to outside databases

Previous GC identifers: GC14P099418 GC14P095843 GC14P100017 GC14P101097 GC14P082210

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DIO3:

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the

inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone

3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2),

respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting

that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development.

This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The

selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of

Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the

recognition of UGA as a Sec codon rather than as a stop signal. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IOD3_HUMAN, P55073

Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and

of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role

in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate

circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid

hormone inactivation during embryological development

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DIO3 gene promoter:
GR Nkx3-1 Nkx3-1 v4 STAT5A Nkx3-1 v1 Nkx3-1 v2 PPAR-alpha Nkx3-1 v3 GR-alpha
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for DIO3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIO3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32

DIO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIO3 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P102027: view genomic region (about GC identifiers)

Start:	102,027,688 bp from pter	End:	102,029,789 bp from pter
Size:	2,102 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IOD3_HUMAN, P55073 (See protein sequence)

Recommended Name: Type III iodothyronine deiodinase

Size: 278 amino acids; 31451 Da

Subunit: Homodimer. May undergo minor heretodimerization with DIO1 and DIO2

Subcellular location: Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II

membrane protein

Secondary accessions: Q8WVN5

Explore the universe of human proteins at neXtProt for DIO3: NX_P55073

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55073

4/10 DME Specific Peptides for DIO3 (P55073) (see all 10)

DFLIIYI

YQGGRGP

FGSCTUP

GNRPLVL

DIO3 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001353.4

ENSEMBL proteins:

ENSP00000427336

Reactome Protein details: P55073
Human Recombinant Protein Products:

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	Uscn Proteins for DIO3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0010008	endosome membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

DIO3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DIO3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DIO3 for domains About GeneDecksing

4 InterPro domains/families:

IPR000643 Iodothyronine_deiodinase

IPR027252 Iodothyronine_deiodinase_I/III

IPR008261 Iodothyronine_deiodinase_AS

IPR012336 Thioredoxin-like_fold

Graphical View of Domain Structure for InterPro Entry P55073

ProtoNet protein and cluster: P55073

1 Blocks protein family: IPB008261 Iodothyronine deiodinase

UniProtKB/Swiss-Prot: IOD3_HUMAN, P55073

Similarity: Belongs to the iodothyronine deiodinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IOD3_HUMAN, P55073

Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and

of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role

in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate

circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid

hormone inactivation during embryological development

Catalytic activity: 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH(2)

Biophysicochemical properties: Kinetic parameters: KM=4.3 nM for Thyroxine; Vmax=1.4 pmol/min/mg enzyme;

Genatlas biochemistry entry for DIO3:

iodothyronine 5'-deiodinase type III,selenocysteine containing,catalyzing tyrosyl ring deiodination,highly expressed in

the placenta and several fetal tissues,restricted to the skin an central nervous system

Enzyme Numbers (IUBMB): EC 1.97.1.11¹ ² EC 1.97.1²

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DIO3
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DIO3:
		hsa-miR-4291 hsa-miR-4283 hsa-miR-214 hsa-miR-922 hsa-miR-191* hsa-miR-761 hsa-miR-552 hsa-miR-1912

		SwitchGear 3'UTR luciferase reporter plasmid: DIO3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIO3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004800	thyroxine 5'-deiodinase activity	NAS	7593630
GO:0033798	thyroxine 5-deiodinase activity	IEA	--

DIO3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DIO3:

Decreased Salmonella enterica

Animal Models:
Mouse knock-out Dio3^tm1Stg for DIO3
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dio3):

cellular

growth/size

homeostasis/metabolism

mortality/aging

reproductive system

DIO3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of thyroid hormone activity

Regulation of thyroid hormone activity	1.00	Thyroxine biosynthesis	0.50
thyroid hormone metabolism I (via deiodination)	0.67	Amine-derived hormones	0.21
thyronamine and iodothyronamine metabolism	0.67

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Metabolism

Metabolism

1.00

Selenium Metabolism and Selenoproteins

Selenium Metabolism and Selenoproteins

1.00

Selenium Pathway

Selenium Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 BioSystems Pathways for DIO3

	Selenium Metabolism and Selenoproteins
	Selenium Pathway
	thyroid hormone metabolism I (via deiodination)
	thyronamine and iodothyronamine metabolism

5 Reactome Pathways for DIO3

	Thyroxine biosynthesis
	Amine-derived hormones
	Metabolism
	Metabolism of amino acids and derivatives
	Regulation of thyroid hormone activity

DIO3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DIO3

2 Interacting proteins for DIO3 (P55073³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRMT5	O14744³	I2D: score=1
PRMT7	Q9NVM4³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006590	thyroid hormone generation	TAS	--
GO:0008150	biological_process	ND	--
GO:0034641	cellular nitrogen compound metabolic process	TAS	--
GO:0042446	hormone biosynthetic process	IEA	--
GO:0044281	small molecule metabolic process	TAS	--

DIO3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DIO3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DIO3

3 HMDB Compounds for DIO3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Iodide	Iodide (see all 10)	20461-54-5	--
Thyroxine	(-)-Thyroxine (see all 33)	51-48-9	--
Thyroxine sulfate	Thyroxine sulfate (see all 8)	77074-49-8	--

10/13 Novoseek chemical compound relationships for DIO3 gene (see all 13) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
3-iodothyronine	98.1	20	12419801 (2), 12586771 (2), 9787088 (1), 16131330 (1) (see all 15)
3,3'-diiodothyronine	84.9	2	15192045 (1), 11375791 (1)
thyroxine	75.6	15	12419801 (2), 16131330 (1), 20458138 (1), 16131331 (1) (see all 10)
selenocysteine	73.7	11	12746313 (3), 7593630 (2), 12399446 (2), 11897672 (1)
triiodothyronine	71.4	12	12419801 (1), 16131330 (1), 20458138 (1), 16131335 (1) (see all 9)
propylthiouracil	62.9	2	9709961 (1)
dithiothreitol	47.1	12	9709961 (1), 12586771 (1), 19819956 (1)
125i	31.6	8	9709961 (1)
alanine	27.1	1	11897672 (1)
cysteine	26	2	12746313 (1), 11897672 (1)

Search CenterWatch for drugs/clinical trials and news about DIO3 / IOD3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DIO3 gene:

NM_001362.3

Unigene Cluster for DIO3:

Deiodinase, iodothyronine, type III

Hs.49322 [show with all ESTs]

Unigene Representative Sequence: NM_001362

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000510508

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DIO3
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DIO3:
		hsa-miR-4291 hsa-miR-4283 hsa-miR-214 hsa-miR-922 hsa-miR-191* hsa-miR-761 hsa-miR-552 hsa-miR-1912

		SwitchGear 3'UTR luciferase reporter plasmid: DIO3 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: DIO3 (NM_001362)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIO3

Additional cDNA sequence:

AK292310.1 BC017717.1 BX161470.1 S79854.1

5 DOTS entries:

DT.95074956 DT.406542 DT.100784404 DT.100784408 DT.100774824

24/38 AceView cDNA sequences (see all 38):

CR591237 CR613810 BX367669 CR607338 BC017717 BX399060 BX161470 BX348985

CR609174 CR602618 AW297126 BP371839 BX388647 BX352031 BX339372 BF980923

BX367768 BX395074 BX378111 BX397665 BX339373 BX347263 BX388587 BX351409

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DIO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAACTCCA

About this image

DIO3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

Genevestigator expression for DIO3

SOURCE GeneReport for Unigene cluster: Hs.49322

UniProtKB/Swiss-Prot: IOD3_HUMAN, P55073

Tissue specificity: Expressed in placenta and several fetal tissues

SABiosciences Custom PCR Arrays for DIO3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIO3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DIO3 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Dio3^{1 , 5}	deiodinase, iodothyronine type III^{1, 5}	87.79(n)¹ 95.05(a)¹	12 (60.56 cM)⁵ 107585¹ NM_172119.2¹ NP_742117.2¹ 110279068⁵
chicken (Gallus gallus)	Aves	DIO3¹	deiodinase, iodothyronine, type III	72.73(n) 63.64(a)	395939 NM_001122648.1 NP_001116120.1
African clawed frog (Xenopus laevis)	Amphibia	LOC397779²	iodothyronine 5-deiodinase type III	77.3(n)	L28111.1
zebrafish (Danio rerio)	Actinopterygii	AY221259.1²	--	79.98(n)	352936 AY221259.1

ENSEMBL Gene Tree for DIO3 (if available)
TreeFam Gene Tree for DIO3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DIO3 gene

DIO2²

2 SIMAP similar genes for DIO3 using alignment to 1 protein entry: IOD3_HUMAN:

DIO1 DIO2

DIO3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201299286^1,2	C	--	82211357(-)	`AAGGGA/CAAGCC`	1	--	us2k¹		0	--	--	--	--
rs114510460^1,2	C,F,	--	82211396(+)	`ACAGCA/GTTTTC`	1	--	us2k¹		1		WA	118
rs150376364^1,2		--	102025713(+)	`CACCTC/GAAAGA`	1	--	us2k¹		0	--	--	--	--
rs191280874^1,2		--	102025736(+)	`GTGGTG/TAGGGG`	1	--	us2k¹		0	--	--	--	--
rs11845960^1,2	C,F,H	--	102025749(+)	`GCTTAG/CGAGCA`	1	--	us2k¹		1		NA	4
rs146474215^1,2		--	102025917(+)	`TCGGGC/GGCTTG`	1	--	us2k¹		0	--	--	--	--
rs12892309^1,2	C	--	102026292(+)	`AGTGTC/ATCGGG`	2	--	us2k¹ ds500¹		1		NA	2
rs199500701^1,2	C	--	102027868(+)	`GGTCGG/AAGAGG`	3	/E /G	us2k¹ mis¹		1		EU	351
rs138578713^1,2		--	102027998(+)	`GGCACG/TGCCTT`	3	T	us2k¹ syn¹		0	--	--	--	--
rs149276303^1,2		--	102028076(+)	`CCCGAG/TCCCGA`	3	E D	mis¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DIO3 (102027688 - 102029789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DIO3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DIO3 for disorders           About GeneDecksing

OMIM gene information: 601038    OMIM disorders: --

20/23 diseases for DIO3 (see all 23):    About MalaCards

familial partial lipodystrophy neonatal thyrotoxicosis thyroid hormone metabolism birth defects

fetal alcohol syndrome thyrotoxicosis lipodystrophy hemangioma

alcoholism hypothyroidism myocardial infarction choriocarcinoma

hepatocellular carcinoma osteoarthritis carcinoma hypoxia

7 Novoseek disease relationships for DIO3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypothyroidism	57	8	16131330 (1), 17628010 (1), 19293265 (1), 11844744 (1) (see all 7)
critically ill	47	5	18212764 (2), 16131330 (1), 16150911 (1)
hemangioma	44.6	3	12419801 (1), 17891232 (1), 16037131 (1)
choriocarcinoma	31.2	2	12970328 (1), 16935842 (1)
hepatocellular carcinoma	4.48	4	12419801 (1), 16935842 (1)
inflammation	0	4	16150911 (2), 18212764 (1)
tumors	0	7	12364418 (2), 17628010 (1), 19548001 (1), 16405410 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: DIO3 (4 documents)

Export disorders for DIO3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DIO3 gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with DIO3)

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Type 3 iodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. (PubMed id 7593630)^{1, 2, 3, 9} Salvatore D.... Larsen P.R. (1995)
Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. (PubMed id 12419801)^{1, 2, 9} Baqui M.... Bianco A.C. (2003)
The thyroid hormone-inactivating deiodinase functions as a homodimer. (PubMed id 18356288)^{1, 2, 9} Sagar G.D....Bianco A.C. (2008)
Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference. (PubMed id 12746313)^{1, 2, 9} Kuiper G.G....Visser T.J. (2003)
Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. (PubMed id 9787088)^{1, 3, 9} Hernandez A....St Germain D.L. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in inta ct cells. (PubMed id 19819956)^{1, 9} Aerts G....Zavacki A.M. (2009)
Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. (PubMed id 15240580)^{1, 9} Kester M.H....Morreale de Escobar G. (2004)
Activity and response to serum of the mammalian thyroid hormone deiodinase 3 gene promoter: identification of a conserved enhancer. (PubMed id 12943987)^{1, 9} Hernandez A. and St Germain D.L. (2003)
Physiology and pathophysiology of type 3 deiodinase in humans. (PubMed id 16131330)^{1, 9} Huang S.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1735	HGNC: 2885	AceView: DIO3	Ensembl:ENSG00000258865	euGenes: HUgn1735
ECgene: DIO3	H-InvDB: DIO3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DIO3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DIO3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DIO3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DIO3 gene:
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GeneCards and IP:
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deiodinase, iodothyronine, type III

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deiodinase, iodothyronine, type III

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