Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DIMT1 Gene

Aliases for DIMT1 Gene

  • DIM1 Dimethyladenosine Transferase 1 Homolog 2 3 4 5
  • Probable 18S RRNA (Adenine(1779)-N(6)/Adenine(1780)-N(6))-Dimethyltransferase 3 4
  • Probable S-Adenosylmethionine-6-N,N-Adenosyl(RRNA) Dimethyltransferase 3 4
  • DIM1 Dimethyladenosine Transferase 1-Like 3 4
  • Probable 18S RRNA Dimethylase 3 4
  • DIMT1L 3 4
  • 18S RRNA (Adenine(1779)-N(6)/Adenine(1780)-N(6))-Dimethyltransferase 3
  • S-Adenosylmethionine-6-N,N-Adenosyl(RRNA) Dimethyltransferase 3
  • DIM1 Dimethyladenosine Transferase 1 Homolog (S. Cerevisiae) 2
  • DIM1 Dimethyladenosine Transferase 1-Like (S. Cerevisiae) 2
  • Probable Dimethyladenosine Transferase 3
  • Dimethyladenosine Transferase 3
  • 18S RRNA Dimethylase 3
  • EC 2.1.1.183 4
  • HSA9761 3
  • HUSSY5 3
  • DIM1 3

External Ids for DIMT1 Gene

Previous HGNC Symbols for DIMT1 Gene

  • DIMT1L

Previous GeneCards Identifiers for DIMT1 Gene

  • GC05M061683

Summaries for DIMT1 Gene

Entrez Gene Summary for DIMT1 Gene

  • The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017]

GeneCards Summary for DIMT1 Gene

DIMT1 (DIM1 Dimethyladenosine Transferase 1 Homolog) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and rRNA methyltransferase activity. An important paralog of this gene is TFB1M.

UniProtKB/Swiss-Prot for DIMT1 Gene

  • Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3-end of 18S rRNA in the 40S particle.

Additional gene information for DIMT1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIMT1 Gene

Genomics for DIMT1 Gene

Regulatory Elements for DIMT1 Gene

Enhancers for DIMT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H062376 0.8 ENCODE 12.2 +27.7 27711 0 ATF1 JUN BACH1 FOSL1 ZNF316 FOXK2 NFE2 ATF7 MAFK NFE2L2 IPO11 DIMT1 KIF2A GC05M062281
GH05H062402 1.1 ENCODE 8.7 +0.3 317 2 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 RNU6-661P KIF2A DIMT1 GC05M062281
GH05H062255 1.2 Ensembl ENCODE 7.2 +147.3 147330 1 HDAC1 HDGF PKNOX1 ZBTB40 GATA2 EGR1 RCOR1 ATF7 RUNX3 IKZF2 KIF2A DIMT1 PIR57118
GH05H062431 1.1 Ensembl ENCODE 7.4 -28.7 -28663 1 TBL1XR1 NFRKB ZNF766 ATF7 CEBPB NCOA1 HDAC8 NR2F2 ZNF592 ZNF589 DIMT1 GC05P062444 IPO11
GH05H062354 0.7 ENCODE 11.4 +49.7 49701 0 SMARCA5 CTCF ZNF654 ZNF3 NR2F1 TRIM22 JUNB REST BATF RAD21 KIF2A DIMT1 IPO11 GC05M062281
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DIMT1 on UCSC Golden Path with GeneCards custom track

Promoters for DIMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000181474 39 2201 HDGF MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for DIMT1 Gene

Chromosome:
5
Start:
62,387,254 bp from pter
End:
62,403,939 bp from pter
Size:
16,686 bases
Orientation:
Minus strand

Genomic View for DIMT1 Gene

Genes around DIMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIMT1 Gene

Proteins for DIMT1 Gene

  • Protein details for DIMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNQ2-DIM1_HUMAN
    Recommended name:
    Probable dimethyladenosine transferase
    Protein Accession:
    Q9UNQ2
    Secondary Accessions:
    • O76025
    • Q9BU77
    • Q9UES1

    Protein attributes for DIMT1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35236 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DIMT1 Gene

neXtProt entry for DIMT1 Gene

Post-translational modifications for DIMT1 Gene

  • Ubiquitination at posLast=4040, isoforms=106, and isoforms=253
  • Modification sites at PhosphoSitePlus

Other Protein References for DIMT1 Gene

No data available for DME Specific Peptides for DIMT1 Gene

Domains & Families for DIMT1 Gene

Gene Families for DIMT1 Gene

Suggested Antigen Peptide Sequences for DIMT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNQ2

UniProtKB/Swiss-Prot:

DIM1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
genes like me logo Genes that share domains with DIMT1: view

Function for DIMT1 Gene

Molecular function for DIMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.
UniProtKB/Swiss-Prot Function:
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3-end of 18S rRNA in the 40S particle.

Enzyme Numbers (IUBMB) for DIMT1 Gene

Gene Ontology (GO) - Molecular Function for DIMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA,IMP 25851604
GO:0003723 RNA binding IEA,IDA 22658674
GO:0008168 methyltransferase activity IEA --
GO:0008649 rRNA methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DIMT1: view
genes like me logo Genes that share phenotypes with DIMT1: view

Animal Model Products

CRISPR Products

miRNA for DIMT1 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DIMT1
  • Applied Biological Materials Clones for DIMT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIMT1 Gene

Localization for DIMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIMT1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DIMT1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DIMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 25851604
GO:0005759 mitochondrial matrix IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DIMT1: view

Pathways & Interactions for DIMT1 Gene

genes like me logo Genes that share pathways with DIMT1: view

Gene Ontology (GO) - Biological Process for DIMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0031167 rRNA methylation IEA,TAS --
GO:0032259 methylation IEA --
GO:2000234 positive regulation of rRNA processing IMP 25851604
genes like me logo Genes that share ontologies with DIMT1: view

No data available for SIGNOR curated interactions for DIMT1 Gene

Drugs & Compounds for DIMT1 Gene

(1) Drugs for DIMT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for DIMT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with DIMT1: view

Transcripts for DIMT1 Gene

Unigene Clusters for DIMT1 Gene

DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DIMT1
  • Applied Biological Materials Clones for DIMT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DIMT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -
SP2:
SP3:

Relevant External Links for DIMT1 Gene

GeneLoc Exon Structure for
DIMT1
ECgene alternative splicing isoforms for
DIMT1

Expression for DIMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DIMT1 Gene

Protein differential expression in normal tissues from HIPED for DIMT1 Gene

This gene is overexpressed in Breast (25.4), Lung (10.3), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIMT1 Gene



Protein tissue co-expression partners for DIMT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DIMT1 Gene:

DIMT1

SOURCE GeneReport for Unigene cluster for DIMT1 Gene:

Hs.731665

Evidence on tissue expression from TISSUES for DIMT1 Gene

  • Nervous system(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DIMT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DIMT1 Gene

Orthologs for DIMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DIMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIMT1 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia DIMT1 33 34
  • 92.97 (n)
mouse
(Mus musculus)
Mammalia Dimt1 33 16 34
  • 89.03 (n)
rat
(Rattus norvegicus)
Mammalia Dimt1 33
  • 87.97 (n)
oppossum
(Monodelphis domestica)
Mammalia DIMT1 34
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DIMT1 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DIMT1 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIMT1 33 34
  • 76.33 (n)
lizard
(Anolis carolinensis)
Reptilia DIMT1 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dimt1 33
  • 75.96 (n)
Str.10770 33
zebrafish
(Danio rerio)
Actinopterygii dimt1l 33 34
  • 73.36 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004465 33
  • 67.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11837 33 34
  • 62.95 (n)
worm
(Caenorhabditis elegans)
Secernentea E02H1.1 33 34
  • 61.42 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D00594g 33
  • 61.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIM1 33 34 36
  • 61.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR026W 33
  • 59.62 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47420 33
  • 56.37 (n)
soybean
(Glycine max)
eudicotyledons Gma.7008 33
rice
(Oryza sativa)
Liliopsida Os10g0183900 33
  • 58.8 (n)
Os.5604 33
barley
(Hordeum vulgare)
Liliopsida Hv.12102 33
wheat
(Triticum aestivum)
Liliopsida Ta.8066 33
corn
(Zea mays)
Liliopsida Zm.5911 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 72 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC336.02 33
  • 60.68 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08968 33
  • 54.61 (n)
Species where no ortholog for DIMT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DIMT1 Gene

ENSEMBL:
Gene Tree for DIMT1 (if available)
TreeFam:
Gene Tree for DIMT1 (if available)

Paralogs for DIMT1 Gene

Paralogs for DIMT1 Gene

Pseudogenes.org Pseudogenes for DIMT1 Gene

genes like me logo Genes that share paralogs with DIMT1: view

Variants for DIMT1 Gene

Sequence variations from dbSNP and Humsavar for DIMT1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000035100 -- 62,403,531(+) GCGAC(C/G)CGCAG intron-variant
rs1000075258 -- 62,396,618(+) GAGTA(G/T)AAGTA intron-variant
rs1000420375 -- 62,399,742(+) TCTAC(A/T)AACAA intron-variant
rs1000767420 -- 62,391,793(+) TATGT(A/G)AGCAA intron-variant
rs1000920968 -- 62,400,021(+) CTTTG(C/T)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIMT1 Gene

Variant ID Type Subtype PubMed ID
dgv1023e199 CNV deletion 23128226
dgv5689n100 CNV gain 25217958
dgv5690n100 CNV gain 25217958
esv2759345 CNV gain+loss 17122850
esv35035 CNV gain 17911159
esv3605231 CNV gain 21293372
esv3605233 CNV gain 21293372
esv3605234 CNV loss 21293372
esv3894198 CNV gain 25118596
nsv598348 CNV gain 21841781
nsv968182 CNV duplication 23825009

Variation tolerance for DIMT1 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIMT1 Gene

Disorders for DIMT1 Gene

Relevant External Links for DIMT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIMT1

No disorders were found for DIMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIMT1 Gene

Publications for DIMT1 Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for DIMT1 Gene

  • Addgene plasmids for DIMT1

Sources for DIMT1 Gene

Content
Loading form....