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Aliases for DIMT1 Gene

Aliases for DIMT1 Gene

  • DIM1 Dimethyladenosine Transferase 1 Homolog (S. Cerevisiae) 2 3
  • DIMT1L 3 4 6
  • Probable 18S RRNA (Adenine(1779)-N(6)/Adenine(1780)-N(6))-Dimethyltransferase 3 4
  • Probable S-Adenosylmethionine-6-N,N-Adenosyl(RRNA) Dimethyltransferase 3 4
  • Probable 18S RRNA Dimethylase 3 4
  • HUSSY5 3 6
  • DIM1 3 6
  • 18S RRNA (Adenine(1779)-N(6)/Adenine(1780)-N(6))-Dimethyltransferase 3
  • S-Adenosylmethionine-6-N,N-Adenosyl(RRNA) Dimethyltransferase 3
  • DIM1 Dimethyladenosine Transferase 1-Like (S. Cerevisiae) 2
  • DIM1 Dimethyladenosine Transferase 1 Homolog 4
  • DIM1 Dimethyladenosine Transferase 1-Like 4
  • Probable Dimethyladenosine Transferase 3
  • Dimethyladenosine Transferase 3
  • 18S RRNA Dimethylase 3
  • EC 4
  • HSA9761 3

External Ids for DIMT1 Gene

Previous HGNC Symbols for DIMT1 Gene

  • DIMT1L

Previous GeneCards Identifiers for DIMT1 Gene

  • GC05M061683

Summaries for DIMT1 Gene

GeneCards Summary for DIMT1 Gene

DIMT1 (DIM1 Dimethyladenosine Transferase 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity. An important paralog of this gene is TFB1M.

UniProtKB/Swiss-Prot for DIMT1 Gene

  • Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3-end of 18S rRNA in the 40S particle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIMT1 Gene

Genomics for DIMT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DIMT1 Gene

62,387,254 bp from pter
62,403,939 bp from pter
16,686 bases
Minus strand

Genomic View for DIMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIMT1 Gene

No data available for Regulatory Elements for DIMT1 Gene

Proteins for DIMT1 Gene

  • Protein details for DIMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable dimethyladenosine transferase
    Protein Accession:
    Secondary Accessions:
    • O76025
    • Q9BU77
    • Q9UES1

    Protein attributes for DIMT1 Gene

    313 amino acids
    Molecular mass:
    35236 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC72947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DIMT1 Gene

neXtProt entry for DIMT1 Gene

Proteomics data for DIMT1 Gene at MOPED

Post-translational modifications for DIMT1 Gene

  • Ubiquitination at Lys40, Lys106, and Lys253
  • Modification sites at PhosphoSitePlus

Other Protein References for DIMT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DIMT1 Gene

Domains for DIMT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UNQ2
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
genes like me logo Genes that share domains with DIMT1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for DIMT1 Gene

Function for DIMT1 Gene

Molecular function for DIMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA
UniProtKB/Swiss-Prot Function:
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3-end of 18S rRNA in the 40S particle.

Enzyme Numbers (IUBMB) for DIMT1 Gene

Gene Ontology (GO) - Molecular Function for DIMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA --
GO:0008168 methyltransferase activity --
GO:0008649 rRNA methyltransferase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0052909 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity IEA --
genes like me logo Genes that share ontologies with DIMT1: view

Phenotypes for DIMT1 Gene

GenomeRNAi human phenotypes for DIMT1:
genes like me logo Genes that share phenotypes with DIMT1: view

Animal Model Products

miRNA for DIMT1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DIMT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DIMT1 Gene

Localization for DIMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIMT1 Gene

Nucleus, nucleolus.

Gene Ontology (GO) - Cellular Components for DIMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DIMT1: view

No data available for Subcellular locations from COMPARTMENTS for DIMT1 Gene

Pathways for DIMT1 Gene

SuperPathways for DIMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DIMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000154 rRNA modification --
GO:0006364 rRNA processing --
GO:0008152 metabolic process --
GO:0031167 rRNA methylation IEA --
genes like me logo Genes that share ontologies with DIMT1: view

No data available for Pathways by source for DIMT1 Gene

Transcripts for DIMT1 Gene

Unigene Clusters for DIMT1 Gene

DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DIMT1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIMT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - -

Relevant External Links for DIMT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIMT1 Gene

mRNA expression in normal human tissues for DIMT1 Gene

Protein differential expression in normal tissues for DIMT1 Gene

This gene is overexpressed in Breast (25.4), Lung (10.3), and Lymph node (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIMT1 Gene

SOURCE GeneReport for Unigene cluster for DIMT1 Gene Hs.731665

genes like me logo Genes that share expressions with DIMT1: view

Expression partners for DIMT1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DIMT1 Gene

Orthologs for DIMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DIMT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DIMT1 35
  • 92.97 (n)
  • 95.53 (a)
DIMT1 36
  • 96 (a)
(Mus musculus)
Mammalia Dimt1 35
  • 89.03 (n)
  • 95.85 (a)
Dimt1 16
Dimt1 36
  • 96 (a)
(Pan troglodytes)
Mammalia DIMT1 35
  • 99.68 (n)
  • 100 (a)
DIMT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dimt1 35
  • 87.97 (n)
  • 94.89 (a)
(Canis familiaris)
Mammalia DIMT1 36
  • 76 (a)
(Monodelphis domestica)
Mammalia DIMT1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia DIMT1 36
  • 50 (a)
(Gallus gallus)
Aves DIMT1 35
  • 76.33 (n)
  • 82.74 (a)
DIMT1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia DIMT1 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dimt1 35
  • 75.96 (n)
  • 87.46 (a)
Str.10770 35
(Danio rerio)
Actinopterygii dimt1l 35
  • 73.36 (n)
  • 85.81 (a)
dimt1l 36
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004465 35
  • 67.25 (n)
  • 75.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11837 35
  • 62.95 (n)
  • 71.78 (a)
CG11837 36
  • 69 (a)
(Caenorhabditis elegans)
Secernentea E02H1.1 35
  • 61.42 (n)
  • 62.24 (a)
E02H1.1 36
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR026W 35
  • 59.62 (n)
  • 60.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D00594g 35
  • 61.37 (n)
  • 61.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIM1 35
  • 61.27 (n)
  • 60.92 (a)
DIM1 36
  • 55 (a)
DIM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47420 35
  • 56.37 (n)
  • 58.68 (a)
(Glycine max)
eudicotyledons Gma.7008 35
(Hordeum vulgare)
Liliopsida Hv.12102 35
(Oryza sativa)
Liliopsida Os.5604 35
Os10g0183900 35
  • 58.8 (n)
  • 62.5 (a)
(Triticum aestivum)
Liliopsida Ta.8066 35
(Zea mays)
Liliopsida Zm.5911 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08968 35
  • 54.61 (n)
  • 56.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC336.02 35
  • 60.68 (n)
  • 62.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
Species with no ortholog for DIMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DIMT1 Gene

Gene Tree for DIMT1 (if available)
Gene Tree for DIMT1 (if available)

Paralogs for DIMT1 Gene

Paralogs for DIMT1 Gene Pseudogenes for DIMT1 Gene

genes like me logo Genes that share paralogs with DIMT1: view

Variants for DIMT1 Gene

Sequence variations from dbSNP and Humsavar for DIMT1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9981 -- 62,388,307(+) AAGAT(A/C)ATTTT downstream-variant-500B
rs26648 -- 62,401,981(+) AACCA(A/G)CTGAG intron-variant
rs26649 -- 62,403,624(-) GGTGC(A/G)GACCA intron-variant
rs27089 -- 62,402,032(-) AGGTA(A/G)AAAGG intron-variant
rs27090 -- 62,402,836(-) CTGCT(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIMT1 Gene

Variant ID Type Subtype PubMed ID
dgv1801e1 CNV Complex 17122850
nsv881727 CNV Loss 21882294
nsv881728 CNV Loss 21882294
essv5631 CNV CNV 17122850
esv35035 CNV Gain 17911159
dgv1023e199 CNV Deletion 23128226

Relevant External Links for DIMT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIMT1 Gene

Disorders for DIMT1 Gene

No disorders were found for DIMT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DIMT1 Gene

Publications for DIMT1 Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PMID: 17314511) Koch H.B. … Hermeking H. (Cell Cycle 2007) 3

Products for DIMT1 Gene

  • Addgene plasmids for DIMT1

Sources for DIMT1 Gene

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