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Aliases for DIEXF Gene

Aliases for DIEXF Gene

  • Digestive Organ Expansion Factor Homolog (Zebrafish) 2 3 5
  • C1orf107 3 4
  • DEF 3 4
  • Digestive Organ Expansion Factor Homolog 3
  • Digestive-Organ Expansion Factor Homolog 3
  • Chromosome 1 Open Reading Frame 107 2
  • DJ434O14.5 3
  • UTP25 3

External Ids for DIEXF Gene

Previous HGNC Symbols for DIEXF Gene

  • C1orf107

Previous GeneCards Identifiers for DIEXF Gene

  • GC01P210002

Summaries for DIEXF Gene

GeneCards Summary for DIEXF Gene

DIEXF (Digestive Organ Expansion Factor Homolog (Zebrafish)) is a Protein Coding gene. Diseases associated with DIEXF include Tietz Albinism-Deafness Syndrome. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and U3 snoRNA binding.

UniProtKB/Swiss-Prot for DIEXF Gene

  • Regulates the p53 pathway to control the expansion growth of digestive organs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIEXF Gene

Genomics for DIEXF Gene

Regulatory Elements for DIEXF Gene

Enhancers for DIEXF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F209822 0.6 Ensembl ENCODE 16 -2.3 -2275 6.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 IRF6 DIEXF SYT14 C1orf74 LOC101930114 TRAF3IP3
GH01F209850 0.5 ENCODE 11.2 +22.6 22624 0.2 CTCF ZNF76 EBF1 ZNF2 RAD21 ZNF101 ZNF366 PATZ1 SMC3 PRDM10 DIEXF GC01M209934
GH01F209765 1.1 FANTOM5 ENCODE 11.2 -60.0 -60006 5.6 HDGF TBP PKNOX1 TBL1XR1 YBX1 RAD21 ZEB1 ZNF335 ELK1 ETV6 G0S2 TRAF3IP3 DIEXF ENSG00000224260 LAMB3 IRF6 C1orf74 LOC101930114
GH01F209862 0.5 ENCODE 11 +34.8 34824 0.2 DIEXF GC01M209934
GH01F209860 0.4 ENCODE 11 +32.5 32534 0.2 CTCF MAZ ZNF654 TRIM22 REST ZNF2 RAD21 JUND KLF16 ZBTB48 DIEXF TRAF3IP3 GC01M209934
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DIEXF on UCSC Golden Path with GeneCards custom track

Promoters for DIEXF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000552203 433 2001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207

Genomic Location for DIEXF Gene

Chromosome:
1
Start:
209,827,967 bp from pter
End:
209,857,565 bp from pter
Size:
29,599 bases
Orientation:
Plus strand

Genomic View for DIEXF Gene

Genes around DIEXF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIEXF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIEXF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIEXF Gene

Proteins for DIEXF Gene

  • Protein details for DIEXF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ4-DIEXF_HUMAN
    Recommended name:
    Digestive organ expansion factor homolog
    Protein Accession:
    Q68CQ4
    Secondary Accessions:
    • O75992
    • Q4VY00
    • Q63HL9

    Protein attributes for DIEXF Gene

    Size:
    756 amino acids
    Molecular mass:
    87055 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI95693.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DIEXF Gene

Post-translational modifications for DIEXF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIEXF Gene

No data available for DME Specific Peptides for DIEXF Gene

Domains & Families for DIEXF Gene

Protein Domains for DIEXF Gene

Suggested Antigen Peptide Sequences for DIEXF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68CQ4

UniProtKB/Swiss-Prot:

DIEXF_HUMAN :
  • Belongs to the def family.
Family:
  • Belongs to the def family.
genes like me logo Genes that share domains with DIEXF: view

No data available for Gene Families for DIEXF Gene

Function for DIEXF Gene

Molecular function for DIEXF Gene

UniProtKB/Swiss-Prot Function:
Regulates the p53 pathway to control the expansion growth of digestive organs.

Gene Ontology (GO) - Molecular Function for DIEXF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019843 rRNA binding IBA --
GO:0034511 U3 snoRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DIEXF: view
genes like me logo Genes that share phenotypes with DIEXF: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIEXF Gene

Localization for DIEXF Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIEXF Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIEXF Gene COMPARTMENTS Subcellular localization image for DIEXF gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DIEXF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IBA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with DIEXF: view

Pathways & Interactions for DIEXF Gene

genes like me logo Genes that share pathways with DIEXF: view

Gene Ontology (GO) - Biological Process for DIEXF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with DIEXF: view

No data available for SIGNOR curated interactions for DIEXF Gene

Transcripts for DIEXF Gene

mRNA/cDNA for DIEXF Gene

Unigene Clusters for DIEXF Gene

Digestive organ expansion factor homolog (zebrafish):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIEXF Gene

No ASD Table

Relevant External Links for DIEXF Gene

GeneLoc Exon Structure for
DIEXF
ECgene alternative splicing isoforms for
DIEXF

Expression for DIEXF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DIEXF Gene

Protein differential expression in normal tissues from HIPED for DIEXF Gene

This gene is overexpressed in Lung (45.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIEXF Gene



Protein tissue co-expression partners for DIEXF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DIEXF Gene:

DIEXF

SOURCE GeneReport for Unigene cluster for DIEXF Gene:

Hs.194754
genes like me logo Genes that share expression patterns with DIEXF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DIEXF Gene

Orthologs for DIEXF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DIEXF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIEXF 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia DIEXF 34 35
  • 88.62 (n)
dog
(Canis familiaris)
Mammalia DIEXF 34 35
  • 87.95 (n)
rat
(Rattus norvegicus)
Mammalia Diexf 34
  • 85.39 (n)
mouse
(Mus musculus)
Mammalia Diexf 34 16 35
  • 85.21 (n)
oppossum
(Monodelphis domestica)
Mammalia DIEXF 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DIEXF 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIEXF 34 35
  • 68.4 (n)
lizard
(Anolis carolinensis)
Reptilia DIEXF 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia diexf 34
  • 67.42 (n)
Str.11330 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16819 34
zebrafish
(Danio rerio)
Actinopterygii diexf 34 35
  • 59.54 (n)
dj434o14.5l 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011170 34
  • 51.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3735 34 35
  • 51.63 (n)
worm
(Caenorhabditis elegans)
Secernentea Y41C4A.9 35
  • 31 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08229g 34
  • 46.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL209C 34
  • 45.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP25 34 35
  • 44.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NOF1 34
  • 49.38 (n)
rice
(Oryza sativa)
Liliopsida Os05g0295100 34
  • 48.95 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01022 34
  • 50.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1827.01c 34
  • 46.16 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1540 34
Species where no ortholog for DIEXF was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIEXF Gene

ENSEMBL:
Gene Tree for DIEXF (if available)
TreeFam:
Gene Tree for DIEXF (if available)

Paralogs for DIEXF Gene

No data available for Paralogs for DIEXF Gene

Variants for DIEXF Gene

Sequence variations from dbSNP and Humsavar for DIEXF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10127446 -- 209,832,741(+) TAGCC(A/G)GGCAT intron-variant
rs10127618 -- 209,832,704(+) ATGGC(A/G)AAACC intron-variant
rs10127937 -- 209,832,476(+) aacat(C/T)ctctc intron-variant
rs10465687 -- 209,844,415(+) cacct(A/G)tggtc intron-variant
rs10489344 -- 209,850,442(+) CTAAC(A/G)TCTTC intron-variant

Variation tolerance for DIEXF Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIEXF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIEXF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DIEXF Gene

Disorders for DIEXF Gene

MalaCards: The human disease database

(1) MalaCards diseases for DIEXF Gene - From: DISEASES

Disorder Aliases PubMed IDs
tietz albinism-deafness syndrome
  • tietz syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DIEXF in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIEXF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIEXF
genes like me logo Genes that share disorders with DIEXF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIEXF Gene

Publications for DIEXF Gene

  1. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. (PMID: 16322560) Chen J. … Peng J. (Genes Dev. 2005) 2 3 22 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for DIEXF Gene

Sources for DIEXF Gene

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