DIEXF Gene
protein-coding GIFtS: 39
GCID: GC01P210002
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digestive organ expansion factor homolog (zebrafish)(Previous name: chromosome 1 open reading frame 107 )
(Previous symbol: C1orf107)
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Aliases
for DIEXF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Digestive Organ Expansion Factor Homolog (Zebrafish)1 2 | | Chromosome 1 Open Reading Frame 1071 | | C1orf1071 2 3 | | DJ434O14.52 | | DEF1 2 3 | | Digestive Organ Expansion Factor Homolog2 | | UTP251 2 | | Digestive-Organ Expansion Factor Homolog2 | | MGC298751 | | |
Export aliases for DIEXF gene to outside databases |
Summaries
for DIEXF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DIEXF_HUMAN, Q68CQ4Function: Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity)
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Genomic Views
for DIEXF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DIEXF
Other transcription factors
Search SABiosciences Chromatin IP Primers for DIEXF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIEXF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.2 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32.2DIEXF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P210002: view genomic region
(about GC identifiers)
Start:
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210,001,312 bp from pter |
End:
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210,030,910 bp from pter |
Size:
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29,599 bases |
Orientation:
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plus strand |
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Proteins
for DIEXF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DIEXF_HUMAN, Q68CQ4 (See
protein sequence)Recommended Name: Digestive organ expansion factor homolog Size: 756 amino acids; 87055 Da
Subcellular location: Nucleus (By similarity). Nucleus, nucleolus
Sequence caution: Sequence=CAI95693.1; Type=Erroneous gene model prediction;
Secondary accessions: O75992 Q4VY00 Q63HL9Explore the universe of human proteins at neXtProt for DIEXF: NX_Q68CQ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q68CQ4
DIEXF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055203.4
ENSEMBL proteins: ENSP00000419005 ENSP00000407345
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
DIEXF for ontologies About GeneDecksing
DIEXF Antibody Products:
Assay Products for DIEXF: |
Protein
Domains /
Families
for DIEXF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DIEXF for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q68CQ4ProtoNet protein and cluster: Q68CQ4 UniProtKB/Swiss-Prot: DIEXF_HUMAN, Q68CQ4Similarity: Belongs to the def family |
Function
for DIEXF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DIEXF_HUMAN, Q68CQ4Function: Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIEXF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIEXF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DIEXF (NM_014388) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DIEXF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIEXF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIEXF |
3 GenomeRNAi human phenotypes for DIEXF:
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Pathways & Interactions
for DIEXF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DIEXF
5/18 Interacting proteins for DIEXF (Q68CQ43) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- |
DIEXF for ontologies About GeneDecksing
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Drugs & Compounds
for DIEXF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DIEXF
Search CenterWatch for drugs/clinical trials and news about DIEXF
|
Transcripts
for DIEXF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DIEXF gene: NM_014388.6 Unigene Cluster for DIEXF: Digestive organ expansion factor homolog (zebrafish) Hs.194754 [show with all ESTs]Unigene Representative Sequence: NM_0143882 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491415(uc001hhr.2 uc009xcu.2) ENST00000457820
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIEXF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIEXF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DIEXF (NM_014388) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DIEXF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIEXF |
Additional cDNA sequence: AK022766.1 AK096118.1 AK123674.1 AK289613.1 AK295799.1 AK314061.1 BC022964.1 BX648514.1 CR749825.1 6 DOTS entries: DT.445301 DT.101955493 DT.75159964 DT.121375412 DT.92052056 DT.95369694 24/146 AceView cDNA sequences (see all 146): AA962243 BQ006029 BC022964 BQ000830 AI982878 AK123674 BE888064 AA724232 AI637490 BE219375 AW405014 BP340942 AI492447 AA043499 NM_014388 N58772 BX402171 CR598885 BQ420891 AI088666 BI822921 BM713317 BM978047 AI474271
GeneLoc Exon Structure
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Expression
for DIEXF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DIEXF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DIEXF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DIEXF
SOURCE GeneReport for Unigene cluster: Hs.194754
SABiosciences Custom PCR Arrays for DIEXF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIEXF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DIEXF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIEXF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIEXF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIEXF |
Orthologs
for DIEXF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for DIEXF gene from 10/34 species (see all 34) About this table
ENSEMBL Gene Tree for DIEXF (if available)
TreeFam Gene Tree for DIEXF (if available) |
Paralogs
for DIEXF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DIEXF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DIEXF (210001312 - 210030910 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DIEXF: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIEXF |
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Disorders
/ Diseases
for DIEXF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DIEXF for disorders About GeneDecksing
2  diseases for DIEXF: About MalaCardsmyeloma malaria
Export disorders for DIEXF gene to outside databases
|
Publications
for DIEXF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DIEXF gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DIEXF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. (PubMed id 16322560)1, 3, 9 Chen J....Peng J. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. (PubMed id 22002106)2 Ahmad Y.... Lamond A.I. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Identification of ubiquitinated proteins from human m ultiple myeloma U266 cells by proteomics. (PubMed id 22108332)1 Jia H....He Q. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for DIEXF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DIEXF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing DIEXF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DIEXF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DIEXF | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DIEXF gene:
Search GeneIP for patents involving DIEXF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DIEXF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DIEXF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DIEXF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIEXF | | | OriGene Protein Over-expression Lysate for DIEXF | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DIEXF | | OriGene 3'-UTR Clone for DIEXF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIEXF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIEXF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DIEXF | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DIEXF | | OriGene Custom Protein Services for DIEXF | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DIEXF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIEXF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIEXF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DIEXF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIEXF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIEXF |
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 |  |  |  | |
| | | | Search Tocris compounds for DIEXF |
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 | | | DIEXF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIEXF |
|  |  |  | | | | Search ThermoFisher Antibodies for DIEXF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIEXF |
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