Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DIEXF Gene

Aliases for DIEXF Gene

  • Digestive Organ Expansion Factor Homolog (Zebrafish) 2 3 5
  • C1orf107 3 4
  • DEF 3 4
  • Digestive-Organ Expansion Factor Homolog 3
  • Chromosome 1 Open Reading Frame 107 2
  • DJ434O14.5 3
  • UTP25 3

External Ids for DIEXF Gene

Previous HGNC Symbols for DIEXF Gene

  • C1orf107

Previous GeneCards Identifiers for DIEXF Gene

  • GC01P210002

Summaries for DIEXF Gene

GeneCards Summary for DIEXF Gene

DIEXF (Digestive Organ Expansion Factor Homolog (Zebrafish)) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding and U3 snoRNA binding.

UniProtKB/Swiss-Prot for DIEXF Gene

  • Regulates the p53 pathway to control the expansion growth of digestive organs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIEXF Gene

Genomics for DIEXF Gene

Regulatory Elements for DIEXF Gene

Enhancers for DIEXF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DIEXF on UCSC Golden Path with GeneCards custom track

Promoters for DIEXF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DIEXF on UCSC Golden Path with GeneCards custom track

Genomic Location for DIEXF Gene

209,827,967 bp from pter
209,857,565 bp from pter
29,599 bases
Plus strand

Genomic View for DIEXF Gene

Genes around DIEXF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIEXF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIEXF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIEXF Gene

Proteins for DIEXF Gene

  • Protein details for DIEXF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Digestive organ expansion factor homolog
    Protein Accession:
    Secondary Accessions:
    • O75992
    • Q4VY00
    • Q63HL9

    Protein attributes for DIEXF Gene

    756 amino acids
    Molecular mass:
    87055 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI95693.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DIEXF Gene

Proteomics data for DIEXF Gene at MOPED

Post-translational modifications for DIEXF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DIEXF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DIEXF Gene

Domains & Families for DIEXF Gene

Protein Domains for DIEXF Gene

Suggested Antigen Peptide Sequences for DIEXF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the def family.
  • Belongs to the def family.
genes like me logo Genes that share domains with DIEXF: view

No data available for Gene Families for DIEXF Gene

Function for DIEXF Gene

Molecular function for DIEXF Gene

UniProtKB/Swiss-Prot Function:
Regulates the p53 pathway to control the expansion growth of digestive organs.

Gene Ontology (GO) - Molecular Function for DIEXF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with DIEXF: view
genes like me logo Genes that share phenotypes with DIEXF: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DIEXF Gene

Localization for DIEXF Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIEXF Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for DIEXF Gene COMPARTMENTS Subcellular localization image for DIEXF gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DIEXF Gene

Pathways & Interactions for DIEXF Gene

genes like me logo Genes that share pathways with DIEXF: view

Pathways by source for DIEXF Gene

Gene Ontology (GO) - Biological Process for DIEXF Gene


No data available for SIGNOR curated interactions for DIEXF Gene

Drugs & Compounds for DIEXF Gene

No Compound Related Data Available

Transcripts for DIEXF Gene

mRNA/cDNA for DIEXF Gene

Unigene Clusters for DIEXF Gene

Digestive organ expansion factor homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIEXF Gene

No ASD Table

Relevant External Links for DIEXF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIEXF Gene

mRNA expression in normal human tissues for DIEXF Gene

Protein differential expression in normal tissues from HIPED for DIEXF Gene

This gene is overexpressed in Lung (45.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIEXF Gene

SOURCE GeneReport for Unigene cluster for DIEXF Gene Hs.194754

genes like me logo Genes that share expression patterns with DIEXF: view

Protein tissue co-expression partners for DIEXF Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DIEXF Gene

Orthologs for DIEXF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DIEXF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DIEXF 35
  • 88.62 (n)
  • 92.03 (a)
  • 89 (a)
(Canis familiaris)
Mammalia DIEXF 35
  • 87.95 (n)
  • 89.38 (a)
  • 91 (a)
(Mus musculus)
Mammalia Diexf 35
  • 85.21 (n)
  • 88.34 (a)
Diexf 16
Diexf 36
  • 86 (a)
(Pan troglodytes)
Mammalia DIEXF 35
  • 99.51 (n)
  • 99.34 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Diexf 35
  • 85.39 (n)
  • 88.98 (a)
(Monodelphis domestica)
Mammalia DIEXF 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia DIEXF 36
  • 76 (a)
(Gallus gallus)
Aves DIEXF 35
  • 68.4 (n)
  • 70.84 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia DIEXF 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia diexf 35
  • 67.42 (n)
  • 68.8 (a)
Str.11330 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16819 35
(Danio rerio)
Actinopterygii diexf 35
  • 59.54 (n)
  • 54.94 (a)
dj434o14.5l 35
diexf 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011170 35
  • 51.68 (n)
  • 43.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3735 35
  • 51.63 (n)
  • 42.54 (a)
CG3735 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea Y41C4A.9 36
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL209C 35
  • 45.75 (n)
  • 35.2 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08229g 35
  • 46.83 (n)
  • 38.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP25 35
  • 44.99 (n)
  • 35.6 (a)
UTP25 36
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NOF1 35
  • 49.38 (n)
  • 38.68 (a)
(Oryza sativa)
Liliopsida Os05g0295100 35
  • 48.95 (n)
  • 39.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1540 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01022 35
  • 50.49 (n)
  • 41.35 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1827.01c 35
  • 46.16 (n)
  • 38.86 (a)
Species with no ortholog for DIEXF:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DIEXF Gene

Gene Tree for DIEXF (if available)
Gene Tree for DIEXF (if available)

Paralogs for DIEXF Gene

No data available for Paralogs for DIEXF Gene

Variants for DIEXF Gene

Sequence variations from dbSNP and Humsavar for DIEXF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs585627 - 209,830,854(-) TTGTT(C/G)TGGTT reference, missense, utr-variant-5-prime
rs16679 -- 209,834,594(+) GATGA(-/CT)CTAGG intron-variant
rs126280 -- 209,846,479(+) TGGGA(A/G)TTTCT intron-variant
rs591779 -- 209,835,997(+) ataca(A/G)atcct intron-variant
rs592164 -- 209,836,027(+) tatct(A/G)cctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIEXF Gene

Variant ID Type Subtype PubMed ID
nsv873139 CNV Gain 21882294

Variation tolerance for DIEXF Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DIEXF Gene

Disorders for DIEXF Gene

Relevant External Links for DIEXF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DIEXF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DIEXF Gene

Publications for DIEXF Gene

  1. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. (PMID: 16322560) Chen J. … Peng J. (Genes Dev. 2005) 2 3 23 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DIEXF Gene

Sources for DIEXF Gene