Aliases for DIDO1 Gene
External Ids for DIDO1 Gene
Previous HGNC Symbols for DIDO1 Gene
Previous GeneCards Identifiers for DIDO1 Gene
Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for DIDO1 Gene
DIDO1 (Death Inducer-Obliterator 1) is a Protein Coding gene. Diseases associated with DIDO1 include Colorectal Adenoma. Among its related pathways are Apoptosis and Autophagy and Cell Cycle, Mitotic. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PHF3.
UniProtKB/Swiss-Prot for DIDO1 Gene
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.
Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.