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Aliases for DIDO1 Gene

Aliases for DIDO1 Gene

  • Death Inducer-Obliterator 1 2 3 5
  • Death-Associated Transcription Factor 1 3 4
  • C20orf158 3 4
  • DATF-1 3 4
  • DATF1 3 4
  • DIO-1 3 4
  • Death Associated Transcription Factor 1 2
  • Chromosome 20 Open Reading Frame 158 2
  • Death-Inducer Obliterator 1 3
  • DJ885L7.8 3
  • KIAA0333 4
  • HDido1 4
  • DIDO2 3
  • DIDO3 3
  • BYE1 3
  • DIO1 3

External Ids for DIDO1 Gene

Previous HGNC Symbols for DIDO1 Gene

  • C20orf158
  • DATF1

Previous GeneCards Identifiers for DIDO1 Gene

  • GC20M060993
  • GC20M061510
  • GC20M058226

Summaries for DIDO1 Gene

Entrez Gene Summary for DIDO1 Gene

  • Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DIDO1 Gene

DIDO1 (Death Inducer-Obliterator 1) is a Protein Coding gene. Diseases associated with DIDO1 include Colorectal Adenoma. Among its related pathways are Meiosis and Cell Cycle, Mitotic. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PHF3.

UniProtKB/Swiss-Prot for DIDO1 Gene

  • Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.

  • Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.

Gene Wiki entry for DIDO1 Gene

Additional gene information for DIDO1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIDO1 Gene

Genomics for DIDO1 Gene

Regulatory Elements for DIDO1 Gene

Enhancers for DIDO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H062300 1.8 FANTOM5 ENCODE dbSUPER 107.2 +634.2 634162 5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC SSRP1 DIDO1 TAF4 ENSG00000226332 MRGBP GID8 RPS21 ADRM1 YTHDF1 LAMA5 LAMA5-AS1
GH20H062500 1.8 FANTOM5 Ensembl ENCODE 73 +436.3 436330 2 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZNF207 ZNF143 DIDO1 TAF4 LAMA5 ENSG00000226332 MRGBP RPS21 HAR1A MTG2 YTHDF1 DPH3P1
GH20H063657 1.2 ENCODE 101.1 -720.5 -720483 2 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 ZNF610 GLIS1 DIDO1 GMEB2 LINC00029 MIR647 RTEL1 LOC105372725 STMN3 UCKL1 TCEA2 MRGBP
GH20H063845 1.6 Ensembl ENCODE dbSUPER 74 -909.4 -909375 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZBTB7B DIDO1 MIR647 UCKL1 PCMTD2 TNFRSF6B RTEL1 ZNF512B PRPF6 ENSG00000237371 CICP4
GH20H062385 1.4 ENCODE dbSUPER 83.5 +550.6 550627 3 HNRNPUL1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF416 ZNF143 DIDO1 LINC00029 TAF4 RPS21 CABLES2 LSM14B ENSG00000226332 LINC01056 LAMA5 YTHDF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DIDO1 on UCSC Golden Path with GeneCards custom track

Promoters for DIDO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139825 52 2601 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for DIDO1 Gene

Chromosome:
20
Start:
62,877,734 bp from pter
End:
62,937,952 bp from pter
Size:
60,219 bases
Orientation:
Minus strand

Genomic View for DIDO1 Gene

Genes around DIDO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIDO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIDO1 Gene

Proteins for DIDO1 Gene

  • Protein details for DIDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTC0-DIDO1_HUMAN
    Recommended name:
    Death-inducer obliterator 1
    Protein Accession:
    Q9BTC0
    Secondary Accessions:
    • A8MY65
    • B9EH82
    • E1P5I1
    • O15043
    • Q3ZTL7
    • Q3ZTL8
    • Q4VXS1
    • Q4VXS2
    • Q4VXV8
    • Q4VXV9
    • Q96D72
    • Q9BQW0
    • Q9BW03
    • Q9H4G6
    • Q9H4G7
    • Q9NTU8
    • Q9NUM8
    • Q9UFB6

    Protein attributes for DIDO1 Gene

    Size:
    2240 amino acids
    Molecular mass:
    243873 Da
    Quaternary structure:
    • Interacts specifically (via PHD-type zinc finger) with histone H3 that is trimethylated at Lys-4 (H3K4me3), histone phosphorylation at Thr-3 or Thr-6 disrupts this binding and promotes translocation of DIDO1 from chromatin to the mitotic spindle during mitosis.
    Miscellaneous:
    • Defects in DIDO1 may be a cause of myeloid neoplasms.
    SequenceCaution:
    • Sequence=BAA20791.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DIDO1 Gene

    Alternative splice isoforms for DIDO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DIDO1 Gene

Post-translational modifications for DIDO1 Gene

  • Ubiquitination at isoforms=2, 3, 4383 and isoforms=4679
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DIDO1 (DATF1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for DIDO1

No data available for DME Specific Peptides for DIDO1 Gene

Domains & Families for DIDO1 Gene

Gene Families for DIDO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DIDO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTC0

UniProtKB/Swiss-Prot:

DIDO1_HUMAN :
  • The PHD-type zinc finger forms an aromatic cage around H3K4me3.
Domain:
  • The PHD-type zinc finger forms an aromatic cage around H3K4me3.
genes like me logo Genes that share domains with DIDO1: view

Function for DIDO1 Gene

Molecular function for DIDO1 Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.
UniProtKB/Swiss-Prot Function:
Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.

Phenotypes From GWAS Catalog for DIDO1 Gene

Gene Ontology (GO) - Molecular Function for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DIDO1: view
genes like me logo Genes that share phenotypes with DIDO1: view

Animal Models for DIDO1 Gene

MGI Knock Outs for DIDO1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DIDO1 Gene

Localization for DIDO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIDO1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DIDO1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DIDO1: view

Pathways & Interactions for DIDO1 Gene

genes like me logo Genes that share pathways with DIDO1: view

Pathways by source for DIDO1 Gene

1 Cell Signaling Technology pathway for DIDO1 Gene
3 Reactome pathways for DIDO1 Gene

Gene Ontology (GO) - Biological Process for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0097190 apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with DIDO1: view

No data available for SIGNOR curated interactions for DIDO1 Gene

Drugs & Compounds for DIDO1 Gene

No Compound Related Data Available

Transcripts for DIDO1 Gene

Unigene Clusters for DIDO1 Gene

Death inducer-obliterator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIDO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: -
SP9:
SP10: - - - - - -
SP11: - - -

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DIDO1 Gene

GeneLoc Exon Structure for
DIDO1
ECgene alternative splicing isoforms for
DIDO1

Expression for DIDO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DIDO1 Gene

Protein differential expression in normal tissues from HIPED for DIDO1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.6), Plasma (10.7), Colon muscle (8.9), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIDO1 Gene



Protein tissue co-expression partners for DIDO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DIDO1 Gene:

DIDO1

SOURCE GeneReport for Unigene cluster for DIDO1 Gene:

Hs.517172

mRNA Expression by UniProt/SwissProt for DIDO1 Gene:

Q9BTC0-DIDO1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DIDO1 Gene

  • Nervous system(4.8)
  • Muscle(4.4)
  • Intestine(4.3)
  • Kidney(4.2)
  • Liver(4.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with DIDO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DIDO1 Gene

Orthologs for DIDO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIDO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIDO1 33 34
  • 98.63 (n)
dog
(Canis familiaris)
Mammalia DIDO1 33 34
  • 77.34 (n)
rat
(Rattus norvegicus)
Mammalia Dido1 33
  • 75.96 (n)
mouse
(Mus musculus)
Mammalia Dido1 33 16 34
  • 75.67 (n)
cow
(Bos Taurus)
Mammalia DIDO1 33 34
  • 74.73 (n)
oppossum
(Monodelphis domestica)
Mammalia DIDO1 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DIDO1 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIDO1 33
  • 64.03 (n)
gga-mir-6681 34
  • 55 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DIDO1 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dido1 33
  • 55.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68807 33
zebrafish
(Danio rerio)
Actinopterygii dido1 34
  • 29 (a)
OneToMany
DIDO1 (1 of 2) 34
  • 24 (a)
OneToMany
wufi35b04 33
fruit fly
(Drosophila melanogaster)
Insecta pps 34
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToOne
Species where no ortholog for DIDO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DIDO1 Gene

ENSEMBL:
Gene Tree for DIDO1 (if available)
TreeFam:
Gene Tree for DIDO1 (if available)

Paralogs for DIDO1 Gene

Paralogs for DIDO1 Gene

(1) SIMAP similar genes for DIDO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DIDO1: view

Variants for DIDO1 Gene

Sequence variations from dbSNP and Humsavar for DIDO1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000017755 -- 62,916,444(+) TTGTC(C/T)CAAGA intron-variant, upstream-variant-2KB
rs1000026508 -- 62,897,815(+) ACGGC(A/G)TGCCA intron-variant
rs1000082404 -- 62,902,186(+) GGTCA(A/C/T)GGTTA intron-variant
rs1000085881 -- 62,937,224(+) CTTCG(C/G)CTCTA intron-variant, upstream-variant-2KB
rs1000096163 -- 62,898,883(+) CACTA(C/T)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIDO1 Gene

Variant ID Type Subtype PubMed ID
esv32958 CNV loss 17666407
nsv428380 CNV loss 18775914
nsv459069 CNV gain 19166990
nsv475456 CNV novel sequence insertion 20440878
nsv586532 CNV gain 21841781
nsv828794 CNV loss 20364138
nsv9825 CNV gain 18304495

Variation tolerance for DIDO1 Gene

Residual Variation Intolerance Score: 4.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIDO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIDO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIDO1 Gene

Disorders for DIDO1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DIDO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal adenoma
  • adenoma of large intestine
- elite association - COSMIC cancer census association via MalaCards
Search DIDO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIDO1

Genetic Association Database (GAD)
DIDO1
Human Genome Epidemiology (HuGE) Navigator
DIDO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIDO1
genes like me logo Genes that share disorders with DIDO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIDO1 Gene

Publications for DIDO1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 45 60
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 60
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60

Products for DIDO1 Gene

Sources for DIDO1 Gene

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