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Aliases for DIDO1 Gene

Aliases for DIDO1 Gene

  • Death Inducer-Obliterator 1 2 3
  • DATF1 3 4 6
  • Death-Associated Transcription Factor 1 3 4
  • C20orf158 3 4
  • DATF-1 3 4
  • DIO-1 3 4
  • DIO1 3 6
  • Death Associated Transcription Factor 1 2
  • Chromosome 20 Open Reading Frame 158 2
  • Death-Inducer Obliterator 1 3
  • DJ885L7.8 3
  • KIAA0333 4
  • HDido1 4
  • DIDO2 3
  • DIDO3 3
  • BYE1 3

External Ids for DIDO1 Gene

Previous Symbols for DIDO1 Gene

  • C20orf158
  • DATF1

Summaries for DIDO1 Gene

Entrez Gene Summary for DIDO1 Gene

  • Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DIDO1 Gene

DIDO1 (Death Inducer-Obliterator 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Metabolism. An important paralog of this gene is SPOCD1.

UniProtKB/Swiss-Prot for DIDO1 Gene

  • Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.

  • Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.

Gene Wiki entry for DIDO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIDO1 Gene

Genomics for DIDO1 Gene

Genomic Location for DIDO1 Gene

62,877,738 bp from pter
62,937,952 bp from pter
60,215 bases
Minus strand

Genomic View for DIDO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DIDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIDO1 Gene

Regulatory Elements for DIDO1 Gene

Proteins for DIDO1 Gene

  • Protein details for DIDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death-inducer obliterator 1
    Protein Accession:
    Secondary Accessions:
    • A8MY65
    • B9EH82
    • E1P5I1
    • O15043
    • Q3ZTL7
    • Q3ZTL8
    • Q4VXS1
    • Q4VXS2
    • Q4VXV8
    • Q4VXV9
    • Q96D72
    • Q9BQW0
    • Q9BW03
    • Q9H4G6
    • Q9H4G7
    • Q9NTU8
    • Q9NUM8
    • Q9UFB6

    Protein attributes for DIDO1 Gene

    2240 amino acids
    Molecular mass:
    243873 Da
    Quaternary structure:
    • Interacts specifically (via PHD-type zinc finger) with histone H3 that is trimethylated at Lys-4 (H3K4me3), histone phosphorylation at Thr-3 or Thr-6 disrupts this binding and promotes translocation of DIDO1 from chromatin to the mitotic spindle during mitosis.
    • Defects in DIDO1 may be a cause of myeloid neoplasms
    • Sequence=BAA20791.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DIDO1 Gene

    Alternative splice isoforms for DIDO1 Gene


neXtProt entry for DIDO1 Gene

Proteomics data for DIDO1 Gene at MOPED

Post-translational modifications for DIDO1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys383 and Lys679

No data available for DME Specific Peptides for DIDO1 Gene

Domains for DIDO1 Gene

Gene Families for DIDO1 Gene

  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for DIDO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The PHD-type zinc finger forms an aromatic cage around H3K4me3:
    • Q9BTC0
  • Contains 1 TFIIS central domain.:
    • Q9BTC0
  • Contains 1 PHD-type zinc finger.:
    • Q9BTC0
genes like me logo Genes that share domains with DIDO1: view

Function for DIDO1 Gene

Molecular function for DIDO1 Gene

UniProtKB/Swiss-Prot Function: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.
UniProtKB/Swiss-Prot Function: Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.

Gene Ontology (GO) - Molecular Function for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with DIDO1: view
genes like me logo Genes that share phenotypes with DIDO1: view

Animal Models for DIDO1 Gene

MGI Knock Outs for DIDO1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DIDO1 Gene

Localization for DIDO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIDO1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for DIDO1 Gene COMPARTMENTS Subcellular localization image for DIDO1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with DIDO1: view

Pathways for DIDO1 Gene

genes like me logo Genes that share pathways with DIDO1: view

Pathways by source for DIDO1 Gene

1 Cell Signaling Technology pathway for DIDO1 Gene
2 BioSystems pathways for DIDO1 Gene

Gene Ontology (GO) - Biological Process for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0097190 apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with DIDO1: view

Transcripts for DIDO1 Gene

Unigene Clusters for DIDO1 Gene

Death inducer-obliterator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DIDO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: -
SP10: - - - - - -
SP11: - - -

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b

Relevant External Links for DIDO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DIDO1 Gene

mRNA expression in normal human tissues for DIDO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DIDO1 Gene

SOURCE GeneReport for Unigene cluster for DIDO1 Gene Hs.517172

mRNA Expression by UniProt/SwissProt for DIDO1 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with DIDO1: view

No data available for mRNA differential expression in normal tissues for DIDO1 Gene

Orthologs for DIDO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIDO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DIDO1 35
  • 98.63 (n)
  • 98.49 (a)
DIDO1 36
  • 99 (a)
(Bos Taurus)
Mammalia DIDO1 35
  • 74.73 (n)
  • 74.01 (a)
DIDO1 36
  • 72 (a)
(Canis familiaris)
Mammalia DIDO1 35
  • 77.34 (n)
  • 76.27 (a)
DIDO1 36
  • 77 (a)
(Mus musculus)
Mammalia Dido1 35
  • 75.67 (n)
  • 75.01 (a)
Dido1 16
Dido1 36
  • 73 (a)
(Monodelphis domestica)
Mammalia DIDO1 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia DIDO1 36
  • 57 (a)
(Rattus norvegicus)
Mammalia Dido1 35
  • 75.96 (n)
  • 75.6 (a)
(Gallus gallus)
Aves -- 36
  • 50 (a)
DIDO1 35
  • 64.03 (n)
  • 62.71 (a)
gga-mir-6681 36
  • 55 (a)
(Anolis carolinensis)
Reptilia DIDO1 36
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68807 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dido1 35
  • 55.3 (n)
  • 52.09 (a)
(Danio rerio)
Actinopterygii dido1 36
  • 29 (a)
DIDO1 (1 of 2) 36
  • 24 (a)
wufi35b04 35
fruit fly
(Drosophila melanogaster)
Insecta pps 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
Species with no ortholog for DIDO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DIDO1 Gene

Gene Tree for DIDO1 (if available)
Gene Tree for DIDO1 (if available)

Paralogs for DIDO1 Gene

Paralogs for DIDO1 Gene

Selected SIMAP similar genes for DIDO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DIDO1: view

Variants for DIDO1 Gene

Sequence variations from dbSNP and Humsavar for DIDO1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs749812 -- 62,934,133(+) AACCC(A/G)TGTGG intron-variant
rs749813 -- 62,934,159(+) TGTCC(C/T)GGGAC intron-variant
rs749814 -- 62,934,162(+) CCCGG(A/G)ACCCA intron-variant
rs750077 - 62,894,868(-) GACGG(C/G)CCCCA reference, missense
rs750078 -- 62,894,828(-) TCTCC(A/G)CCAGT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for DIDO1 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv428380 CNV Loss 18775914
dgv4614n71 CNV Loss 21882294
nsv9825 CNV Gain 18304495
nsv913124 CNV Loss 21882294
nsv913127 CNV Loss 21882294
nsv828794 CNV Loss 20364138
nsv913128 CNV Loss 21882294
nsv913129 CNV Loss 21882294
esv32958 CNV Loss 17666407
nsv913130 CNV Loss 21882294
dgv4617n71 CNV Loss 21882294
nsv459069 CNV Gain 19166990
dgv4618n71 CNV Loss 21882294

Relevant External Links for DIDO1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIDO1 Gene

Disorders for DIDO1 Gene

Relevant External Links for DIDO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DIDO1: view

No data available for UniProtKB/Swiss-Prot for DIDO1 Gene

Publications for DIDO1 Gene

  1. Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells. (PMID: 18298900) Wang Y. … Wu Q.L. (Acta Pharmacol. Sin. 2008) 3 23
  2. [Mechanism of gambogic acid-induced apoptosis in Raji cells]. (PMID: 19236754) Wang Y. … He J. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 23
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  4. DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. (PMID: 10393935) GarcA-a-Domingo D. … MartA-nez-A C. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for DIDO1 Gene

Sources for DIDO1 Gene

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