Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DIDO1 Gene

protein-coding GIFtS: 56
GCID: GC20M061510

death inducer-obliterator 1

(Previous names: chromosome 20 open reading frame 158, death associated...)
(Previous symbols: C20orf158, DATF1)

Explore 9 diseases affiliated with
DIDO1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Death Inducer-Obliterator 1¹ ²		DATF-1² ³
DATF1¹ ² ³ ⁵		FLJ11265¹
C20orf158¹ ² ³		Chromosome 20 Open Reading Frame 158¹
DIO-1¹ ² ³		Death Associated Transcription Factor 1¹
DIO1¹ ² ⁵		DIDO2²
BYE1¹ ²		DIDO3²
DJ885L7.8¹		Death-Inducer Obliterator 1²
KIAA0333¹ ³		HDido1¹
Death-Associated Transcription Factor 1² ³

External Ids:	HGNC: 2680¹	Entrez Gene: 11083²	Ensembl: ENSG00000101191⁷	OMIM: 604140⁵	UniProtKB: Q9BTC0³

Export aliases for DIDO1 gene to outside databases

Previous GC identifers: GC20M060993 GC20M058226

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DIDO1:

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central

importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is

upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic

signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene

is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts

have been found for this gene, encoding multiple isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DIDO1_HUMAN, Q9BTC0

Function: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor

Gene Wiki entry for DIDO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011333.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DIDO1 gene promoter:
CUTL1 XBP-1 Arnt Meis-1b POU2F1 POU2F1a Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DIDO1 promoter sequence

Search SABiosciences Chromatin IP Primers for DIDO1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIDO1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

DIDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DIDO1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M061510: view genomic region (about GC identifiers)

Start:	61,509,090 bp from pter	End:	61,569,304 bp from pter
Size:	60,215 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DIDO1_HUMAN, Q9BTC0 (See protein sequence)

Recommended Name: Death-inducer obliterator 1

Size: 2240 amino acids; 243873 Da

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the nucleus after

pro-apoptotic stimuli (By similarity)

Miscellaneous: Defects in DIDO1 may be a cause of myeloid neoplasms

Sequence caution: Sequence=BAA20791.2; Type=Erroneous initiation;

Secondary accessions: A8MY65 B9EH82 E1P5I1 O15043 Q3ZTL7 Q3ZTL8 Q4VXS1 Q4VXS2 Q4VXV8 Q4VXV9 Q96D72

Q9BQW0 Q9BW03 Q9H4G6 Q9H4G7 Q9NTU8 Q9NUM8 Q9UFB6

Alternative splicing: 4 isoforms: Q9BTC0-4 Q9BTC0-1 Q9BTC0-2 Q9BTC0-3 (No experimental confirmation available. Ref.7 (AAH00770) sequence is in conflict in position: 535:S->L)

Explore the universe of human proteins at neXtProt for DIDO1: NX_Q9BTC0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BTC0

DIDO1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001180298.1 NP_001180299.1 NP_071388.2 NP_149072.2 NP_542986.1 NP_542987.2

ENSEMBL proteins:

ENSP00000378752 ENSP00000378749 ENSP00000359397 ENSP00000359394 ENSP00000346692

ENSP00000359391 ENSP00000266070 ENSP00000378744 ENSP00000266071

Reactome Protein details: Q9BTC0
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for DIDO1
	GenScript Custom Purified and Recombinant Proteins Services for DIDO1
	Novus Biologicals DIDO1 Proteins Novus Biologicals DIDO1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DIDO1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

DIDO1 for ontologies About GeneDecksing

DIDO1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for DIDO1
	Cell Signaling Technology (CST) Antibodies for DIDO1 (DATF1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for DIDO1
	GenScript Custom Superior Antibodies Services for DIDO1
	Novus Biologicals DIDO1 Antibodies
	Search for Antibodies for DIDO1 at Abcam
	Uscn Antibodies for DIDO1
	Search ThermoFisher Antibodies for DIDO1

Assay Products for DIDO1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DIDO1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DIDO1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DIDO1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR019786 Zinc_finger_PHD-type_CS

IPR001965 Znf_PHD

IPR003618 TFIIS_cen_dom

IPR012921 SPOC_C

IPR017890 TFS2M

Graphical View of Domain Structure for InterPro Entry Q9BTC0

ProtoNet protein and cluster: Q9BTC0

3 Blocks protein families:

IPB001209 Ribosomal protein S14

IPB001965 Zn-finger-like

IPB012921 SPOC

UniProtKB/Swiss-Prot: DIDO1_HUMAN, Q9BTC0

Similarity: Contains 1 PHD-type zinc finger

Similarity: Contains 1 TFIIS central domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DIDO1_HUMAN, Q9BTC0

Function: Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor

miRNA Products:		OriGene 3'-UTR Clone (see all 4): DIDO1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DIDO1
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate DIDO1 (see all 39):
		hsa-miR-142-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-520g hsa-miR-3148 hsa-miR-223* hsa-miR-3163 hsa-miR-3688-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DIDO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DIDO1 (see all 7) OriGene shRNA RFP: DIDO1 OriGene siRNA: DIDO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DIDO1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DIDO1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIDO1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIDO1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): DIDO1 (NM_033081)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIDO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIDO1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DIDO1
		Search LifeMap BioReagents cell lines for DIDO1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIDO1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

DIDO1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for DIDO1:

Increased HPV18 LCR reporter a

Increased cell death HMECs cel

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Dido1^tm1Cmar for DIDO1
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dido1):

cellular	embryogenesis	hematopoietic system	immune system	mortality/aging
reproductive system

DIDO1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Meiotic Synapsis

	Meiotic Synapsis	1.00			Chromosome Maintenance	0.56
	Meiosis	0.70

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Synapsis

Synapsis

1.00

Cell Cycle

Cell Cycle

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for DIDO1

Apoptosis and Autophagy

5 Reactome Pathways for DIDO1

	Synapsis
	Meiotic Synapsis
	Cell Cycle
	Meiosis
	Chromosome Maintenance

DIDO1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DIDO1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/750 Interacting proteins for DIDO1 (Q9BTC0^{2, 3} ENSP00000266070⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 750)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HNRNPK	P61978²^,³, ENSP00000365439⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000365439
SRSF1	Q07955²^,³, ENSP00000258962⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000258962
PARP2	Q9UGN5²^,³, ENSP00000250416⁴	MINT-8201842 I2D: score=1 STRING: ENSP00000250416
CDC5L	Q99459², ENSP00000360532⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000360532
SNW1	Q13573², ENSP00000261531⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000261531

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006915	apoptotic process	IEA	--

DIDO1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DIDO1
Search CenterWatch for drugs/clinical trials and news about DIDO1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DIDO1 gene (6 alternative transcripts):

NM_001193369.1 NM_001193370.1 NM_022105.4 NM_033081.2 NM_080796.3 NM_080797.3

Unigene Cluster for DIDO1:

Death inducer-obliterator 1

Hs.517172 [show with all ESTs]

Unigene Representative Sequence: NM_033081

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395343(uc002ydr.2) ENST00000461792 ENST00000395340(uc002ydt.2)

ENST00000370371(uc002ydx.2) ENST00000370368(uc002ydw.2) ENST00000354665(uc002ydv.2)

ENST00000370366(uc011aao.1) ENST00000266070(uc002yds.2) ENST00000395335(uc002ydu.2)

ENST00000266071

miRNA Products:		OriGene 3'-UTR Clone (see all 4): DIDO1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DIDO1
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate DIDO1 (see all 39):
		hsa-miR-142-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-520g hsa-miR-3148 hsa-miR-223* hsa-miR-3163 hsa-miR-3688-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DIDO1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DIDO1 (see all 7) OriGene shRNA RFP: DIDO1 OriGene siRNA: DIDO1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DIDO1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIDO1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIDO1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): DIDO1 (NM_033081)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DIDO1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIDO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIDO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DIDO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIDO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIDO1

Additional cDNA sequence:

AB002331.2 AF085876.1 AK002127.1 AL133063.1 AY481571.1 AY481572.1 BC000770.2 BC004237.2

BC012757.2 BC014489.1 BC014615.2 BC137177.1

24/30 DOTS entries (see all 30):

DT.100820740 DT.95186271 DT.97816042 DT.102835540 DT.100820735 DT.216513 DT.112978 DT.75108929

DT.120826543 DT.100638828 DT.105391 DT.75103965 DT.120826537 DT.40268756 DT.40313105 DT.92451342

DT.100820737 DT.92451337 DT.100681653 DT.100695980 DT.102835539 DT.120826529 DT.120826575 DT.120826660

24/302 AceView cDNA sequences (see all 302):

BM129156 AW631117 BM848250 AA938656 BM804056 BG480592 AA768148 BM720855

AA829787 AA760625 BM843075 CD678291 NM_017896 BM452897 AK000609 CK904965

AI128091 BM848307 AA483300 AK025775 BM841917 AA351620 R46733 BM670727

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DIDO1 (see all 11) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13	^
SP1:													-		-				-																		-										-
SP2:					-		-		-		-		-		-				-																		-										-
SP3:															-				-																		-
SP4:					-		-		-		-		-		-				-																		-
SP5:															-				-				-		-		-		-		-		-				-

ExUns:	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DIDO1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DIDO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACGACCTA

About this image
See DIDO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DIDO1

SOURCE GeneReport for Unigene cluster: Hs.517172

UniProtKB/Swiss-Prot: DIDO1_HUMAN, Q9BTC0

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for DIDO1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIDO1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DIDO1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIDO1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIDO1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIDO1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DIDO1 gene from 8/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dido1^{1 , 5}	death inducer-obliterator 1^{1, 5}	76.39(n)¹ 75.82(a)¹		2 (103.20 cM)⁵ 23856¹ NM_175551.3¹ NP_780760.2¹ 180657964⁵
chicken (Gallus gallus)	Aves	DIDO1¹	death inducer-obliterator 1	62.57(n) 61.05(a)		419234 XM_001234736.2 XP_001234737.2
lizard (Anolis carolinensis)	Reptilia	DIDO1⁶	--	50(a)	1 ↔ 1	4(152515768-152561648)
African clawed frog (Xenopus laevis)	Amphibia	MGC68807²	hypothetical protein MGC68807	75.97(n)		BC060442.1
zebrafish (Danio rerio)	Actinopterygii	wufi35b04²	Transcribed sequence with weak similarity to protein more	77.31(n)		57065661
fruit fly (Drosophila melanogaster)	Insecta	pps⁶	protein partner of snf	9(a)	possible ortholog	3R(8239550-8246973)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G25640⁶ AT5G25520⁶ (see all 4)	SPOC domain / Transcription elongation factor S-II... SPOC dand transcription elongation factor S-II dom... (see all 4)	13(a) 12(a) (see all 4)	many ↔ many many ↔ many (see all 4)	2(10910498-10913969) 5(8885088-8889620)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	transcription factor S-II, central domain containi... SPOC domain containing protein, putative, expresse... (see all 3)	13(a) 12(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(6083116-6089638) 6(23441842-23448456)

ENSEMBL Gene Tree for DIDO1 (if available)
TreeFam Gene Tree for DIDO1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DIDO1 gene

SPOCD1² PHF3²

1 SIMAP similar gene for DIDO1 using alignment to 1 protein entry: DIDO1_HUMAN:

PHF8

DIDO1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73304507^1,2	C,	--	58226075(+)	`ACACTC/GTGCTG`	2	--	ds500¹		3		WA NA	240
rs73918851^1,2	C,	--	58226314(+)	`GCACCC/TGGCCG`	2	--	ds500¹		2		WA	120
rs76041129^1,2	C,	--	58226759(+)	`ACCAAA/GCATCT`	2	--	ut3¹		2		CSA WA	119
rs45476899^1,2		--	58226982(+)	`TACTCA/GAAAAA`	2	--	ut3¹		0	--	--	--	--
rs57235678^1,2	F,	--	58227152(+)	`GGGCCG/AAGCGT`	2	--	ut3¹		1		WA	118
rs73304510^1,2	C,F,	--	58227703(+)	`AAAGAT/GAACTA`	2	--	ut3¹		3		WA CSA	122
rs6011439^1,2	C,F,H	--	58228744(+)	`GTGCAG/AGCGCC`	4	/P /L	mis¹ ese³		10		NS EA NA	1210
rs112034091^1,2	C,F,	--	58230444(+)	`GCTGCA/CGCTGC`	4	A	syn¹		2		CSA NA	4552
rs6062735^1,2	H	--	58230755(+)	`CTCCAG/CCGGTG`	4	/L /V	mis¹ ese³		4		NS EA	418
rs8123160^1,2	C,F,H	--	58230833(+)	`TGCTGT/CGGCTG`	4	/T /A	mis¹ ese³		7		NS EA NA	4866

HapMap Linkage Disequilibrium report for DIDO1 (61509090 - 61569304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DIDO1
2 CNVs: 31044 7314

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIDO1

DNA2.0 Custom Variant and Variant Library Synthesis for DIDO1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DIDO1 for disorders           About GeneDecksing

OMIM gene information: 604140    OMIM disorders: --

9 diseases for DIDO1:    About MalaCards

maple syrup urine disease myelodysplastic myeloproliferative cancer male breast cancer myelodysplastic syndrome

migraine breast cancer esophagitis adenocarcinoma

hepatitis

Human Genome Epidemiology (HuGE) Navigator: DIDO1 (7 documents)

Export disorders for DIDO1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DIDO1 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with DIDO1)

Utopia: connect your pdf to the dynamic
world of online information

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms. (PubMed id 16127461)^{1, 2} Futterer A.... Martinez-A C. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. (PubMed id 10393935)^{1, 3} Garcia-Domingo D....Martinez-A C. (1999)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2} Nagase T.... Ohara O. (1997)
[Mechanism of gambogic acid-induced apoptosis in Raji cells] (PubMed id 19236754)^{1, 9} Wang Y....He J. (2009)
Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells. (PubMed id 18298900)^{1, 9} Wang Y....Wu Q.L. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11083	HGNC: 2680	AceView: C20orf11	Ensembl:ENSG00000101191	euGenes: HUgn11083
ECgene: DIDO1	H-InvDB: DIDO1

(According to HUGE)
About This Section

HUGE: KIAA0333

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DIDO1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DIDO1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DIDO1 gene:
Search GeneIP for patents involving DIDO1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for DIDO1 (DIDO1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for DIDO1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DIDO1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DIDO1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DIDO1		OriGene 3'-UTR Clone for DIDO1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DIDO1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DIDO1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DIDO1		OriGene Custom Protein Services for DIDO1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DIDO1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DIDO1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DIDO1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DIDO1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DIDO1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DIDO1

	GenScript Custom Purified and Recombinant Proteins Services for DIDO1		GenScript cDNA clones with any tag delivered in your preferred vector for DIDO1
	GenScript Custom Assay Services for DIDO1		GenScript Custom Superior Antibodies Services for DIDO1
	GenScript Custom overexpressing Cell Line Services for DIDO1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for DIDO1 (DATF1)

	Regulatory tfbs in DIDO1 promoter
	Search Chromatin IP Primers for DIDO1
	RT² qPCR Primer Assay in human, mouse, rat DIDO1
	Search GNC Networks for DIDO1
	SABiosciences Custom PCR Arrays for DIDO1

Search Tocris compounds for DIDO1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DIDO1 antibodies
	DIDO1 proteins
	DIDO1 lysates

	Search for Antibodies for DIDO1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for DIDO1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

DIDO1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DIDO1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DIDO1

	SwitchGear 3'UTR luciferase reporter plasmids for DIDO1
	SwitchGear Promoter luciferase reporter plasmids for DIDO1

Search ThermoFisher Antibodies for DIDO1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DIDO1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DIDO1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

DIDO1 Gene

death inducer-obliterator 1

Aliases
for DIDO1 gene

Summaries
for DIDO1 gene

Genomic Views
for DIDO1 gene

Proteins
for DIDO1 gene

Protein Domains /
Families
for DIDO1 gene

Function
for DIDO1 gene

Pathways & Interactions
for DIDO1 gene

Drugs & Compounds
for DIDO1 gene

Transcripts
for DIDO1 gene

Expression
for DIDO1 gene

Orthologs
for DIDO1 gene

Paralogs
for DIDO1 gene

Genomic Variants
for DIDO1 gene

Disorders / Diseases
for DIDO1 gene

Publications
for DIDO1 gene

External Searches for DIDO1 gene

Genome Databases showing DIDO1 gene

Other Databases showing DIDO1 gene

Specialized Databases showing DIDO1 gene

Intellectual Property
for DIDO1 gene

Products
for DIDO1 gene

View Random Gene

Advanced Search

Export list of displayed genes

DIDO1 Gene

death inducer-obliterator 1

Aliasesfor DIDO1 gene

Summariesfor DIDO1 gene

Genomic Viewsfor DIDO1 gene

Proteinsfor DIDO1 gene

Protein Domains /Familiesfor DIDO1 gene

Functionfor DIDO1 gene

Pathways & Interactionsfor DIDO1 gene

Drugs & Compoundsfor DIDO1 gene

Transcriptsfor DIDO1 gene

Expression for DIDO1 gene

Orthologsfor DIDO1 gene

Paralogsfor DIDO1 gene

Genomic Variantsfor DIDO1 gene

Disorders / Diseasesfor DIDO1 gene

Publicationsfor DIDO1 gene

External Searches for DIDO1 gene

Genome Databases showing DIDO1 gene

Other Databases showing DIDO1 gene

Specialized Databases showing DIDO1 gene

Intellectual Propertyfor DIDO1 gene

Productsfor DIDO1 gene

View Random Gene

Aliases
for DIDO1 gene

Summaries
for DIDO1 gene

Genomic Views
for DIDO1 gene

Proteins
for DIDO1 gene

Protein Domains /
Families
for DIDO1 gene

Function
for DIDO1 gene

Pathways & Interactions
for DIDO1 gene

Drugs & Compounds
for DIDO1 gene

Transcripts
for DIDO1 gene

Expression
for DIDO1 gene

Orthologs
for DIDO1 gene

Paralogs
for DIDO1 gene

Genomic Variants
for DIDO1 gene

Disorders / Diseases
for DIDO1 gene

Publications
for DIDO1 gene

Intellectual Property
for DIDO1 gene

Products
for DIDO1 gene