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Aliases for DIDO1 Gene

Aliases for DIDO1 Gene

  • Death Inducer-Obliterator 1 2 3 5
  • Death-Associated Transcription Factor 1 3 4
  • C20orf158 3 4
  • DATF-1 3 4
  • DATF1 3 4
  • DIO-1 3 4
  • Death Associated Transcription Factor 1 2
  • Chromosome 20 Open Reading Frame 158 2
  • Death-Inducer Obliterator 1 3
  • DJ885L7.8 3
  • KIAA0333 4
  • HDido1 4
  • DIDO2 3
  • DIDO3 3
  • BYE1 3
  • DIO1 3

External Ids for DIDO1 Gene

Previous HGNC Symbols for DIDO1 Gene

  • C20orf158
  • DATF1

Previous GeneCards Identifiers for DIDO1 Gene

  • GC20M060993
  • GC20M061510
  • GC20M058226

Summaries for DIDO1 Gene

Entrez Gene Summary for DIDO1 Gene

  • Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DIDO1 Gene

DIDO1 (Death Inducer-Obliterator 1) is a Protein Coding gene. Diseases associated with DIDO1 include Colorectal Adenoma. Among its related pathways are Apoptosis and Autophagy and Meiosis. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PHF3.

UniProtKB/Swiss-Prot for DIDO1 Gene

  • Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.

  • Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.

Gene Wiki entry for DIDO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DIDO1 Gene

Genomics for DIDO1 Gene

Regulatory Elements for DIDO1 Gene

Enhancers for DIDO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F062898 0.9 Ensembl ENCODE 22.4 +38.0 37986 3.6 HDGF ATF1 ZFP64 ARID4B SIN3A YBX1 FEZF1 ZNF48 GLIS2 ZNF143 DIDO1 RTEL1 ARFGAP1 GID8 TCFL5 TNFRSF6B GMEB2 SLC17A9 ARF4P2 ENSG00000273759
GH20F062913 1.4 Ensembl ENCODE 20.2 +22.9 22857 4.0 ATF1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF48 ZNF121 SLC30A9 FOS DIDO1 GID8 TCFL5 TNFRSF6B SLC17A9 ENSG00000273759 ARF4P2
GH20F062903 0.2 ENCODE 17.4 +34.4 34377 0.8 PAF1 GLIS2 POLR2A SCRT2 GLIS1 INSM2 ZIC2 DIDO1 GID8 TCFL5 SLC17A9 ENSG00000273759 ARF4P2
GH20F062873 1.3 FANTOM5 Ensembl ENCODE 13.8 +62.4 62398 4.3 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS DEK DIDO1 SLC17A9 GID8 OGFR-AS1 BHLHE23 TCFL5 ARF4P2 ENSG00000273759
GH20F062922 1.2 FANTOM5 ENCODE 12.4 +11.5 11487 8.5 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DIDO1 SLC17A9 GID8 COL9A3 ENSG00000273759 ARF4P2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DIDO1 on UCSC Golden Path with GeneCards custom track

Promoters for DIDO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001450375 252 3001 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for DIDO1 Gene

Chromosome:
20
Start:
62,877,734 bp from pter
End:
62,937,952 bp from pter
Size:
60,219 bases
Orientation:
Minus strand

Genomic View for DIDO1 Gene

Genes around DIDO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DIDO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DIDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DIDO1 Gene

Proteins for DIDO1 Gene

  • Protein details for DIDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTC0-DIDO1_HUMAN
    Recommended name:
    Death-inducer obliterator 1
    Protein Accession:
    Q9BTC0
    Secondary Accessions:
    • A8MY65
    • B9EH82
    • E1P5I1
    • O15043
    • Q3ZTL7
    • Q3ZTL8
    • Q4VXS1
    • Q4VXS2
    • Q4VXV8
    • Q4VXV9
    • Q96D72
    • Q9BQW0
    • Q9BW03
    • Q9H4G6
    • Q9H4G7
    • Q9NTU8
    • Q9NUM8
    • Q9UFB6

    Protein attributes for DIDO1 Gene

    Size:
    2240 amino acids
    Molecular mass:
    243873 Da
    Quaternary structure:
    • Interacts specifically (via PHD-type zinc finger) with histone H3 that is trimethylated at Lys-4 (H3K4me3), histone phosphorylation at Thr-3 or Thr-6 disrupts this binding and promotes translocation of DIDO1 from chromatin to the mitotic spindle during mitosis.
    Miscellaneous:
    • Defects in DIDO1 may be a cause of myeloid neoplasms.
    SequenceCaution:
    • Sequence=BAA20791.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DIDO1 Gene

    Alternative splice isoforms for DIDO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DIDO1 Gene

Post-translational modifications for DIDO1 Gene

  • Ubiquitination at Lys 383 and Lys 679
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DIDO1 (DATF1)
  • Cloud-Clone Corp. Antibodies for DIDO1
  • Santa Cruz Biotechnology (SCBT) Antibodies for DIDO1

No data available for DME Specific Peptides for DIDO1 Gene

Domains & Families for DIDO1 Gene

Gene Families for DIDO1 Gene

Suggested Antigen Peptide Sequences for DIDO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTC0

UniProtKB/Swiss-Prot:

DIDO1_HUMAN :
  • The PHD-type zinc finger forms an aromatic cage around H3K4me3.
  • Contains 1 PHD-type zinc finger.
Domain:
  • The PHD-type zinc finger forms an aromatic cage around H3K4me3.
  • Contains 1 TFIIS central domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with DIDO1: view

Function for DIDO1 Gene

Molecular function for DIDO1 Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.
UniProtKB/Swiss-Prot Function:
Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.

Gene Ontology (GO) - Molecular Function for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DIDO1: view
genes like me logo Genes that share phenotypes with DIDO1: view

Animal Models for DIDO1 Gene

MGI Knock Outs for DIDO1:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DIDO1 Gene

Localization for DIDO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DIDO1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Translocates to the nucleus after pro-apoptotic stimuli (By similarity). Translocates to the mitotic spindle upon loss of interaction with H3K4me3 during early mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DIDO1 Gene COMPARTMENTS Subcellular localization image for DIDO1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DIDO1: view

Pathways & Interactions for DIDO1 Gene

genes like me logo Genes that share pathways with DIDO1: view

Pathways by source for DIDO1 Gene

1 Cell Signaling Technology pathway for DIDO1 Gene
3 Reactome pathways for DIDO1 Gene

Gene Ontology (GO) - Biological Process for DIDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0097190 apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with DIDO1: view

No data available for SIGNOR curated interactions for DIDO1 Gene

Transcripts for DIDO1 Gene

Unigene Clusters for DIDO1 Gene

Death inducer-obliterator 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DIDO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: -
SP9:
SP10: - - - - - -
SP11: - - -

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DIDO1 Gene

GeneLoc Exon Structure for
DIDO1
ECgene alternative splicing isoforms for
DIDO1

Expression for DIDO1 Gene

mRNA expression in normal human tissues for DIDO1 Gene

Protein differential expression in normal tissues from HIPED for DIDO1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.6), Plasma (10.7), Colon muscle (8.9), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DIDO1 Gene



Protein tissue co-expression partners for DIDO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DIDO1 Gene:

DIDO1

SOURCE GeneReport for Unigene cluster for DIDO1 Gene:

Hs.517172

mRNA Expression by UniProt/SwissProt for DIDO1 Gene:

Q9BTC0-DIDO1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DIDO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DIDO1 Gene

Orthologs for DIDO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DIDO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DIDO1 34 35
  • 98.63 (n)
dog
(Canis familiaris)
Mammalia DIDO1 34 35
  • 77.34 (n)
rat
(Rattus norvegicus)
Mammalia Dido1 34
  • 75.96 (n)
mouse
(Mus musculus)
Mammalia Dido1 34 16 35
  • 75.67 (n)
cow
(Bos Taurus)
Mammalia DIDO1 34 35
  • 74.73 (n)
oppossum
(Monodelphis domestica)
Mammalia DIDO1 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DIDO1 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves DIDO1 34
  • 64.03 (n)
gga-mir-6681 35
  • 55 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DIDO1 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dido1 34
  • 55.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68807 34
zebrafish
(Danio rerio)
Actinopterygii dido1 35
  • 29 (a)
OneToMany
DIDO1 (1 of 2) 35
  • 24 (a)
OneToMany
wufi35b04 34
fruit fly
(Drosophila melanogaster)
Insecta pps 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToOne
Species where no ortholog for DIDO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DIDO1 Gene

ENSEMBL:
Gene Tree for DIDO1 (if available)
TreeFam:
Gene Tree for DIDO1 (if available)

Paralogs for DIDO1 Gene

Paralogs for DIDO1 Gene

(1) SIMAP similar genes for DIDO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DIDO1: view

Variants for DIDO1 Gene

Sequence variations from dbSNP and Humsavar for DIDO1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1054866 -- 62,939,856(+) TACTT(A/C)GTATA intron-variant, upstream-variant-2KB
rs10560062 -- 62,883,817(+) TGAGA(-/CT)CTGTC intron-variant
rs1056984 -- 62,887,690(-) TGTGC(A/G)GGGCC intron-variant, utr-variant-3-prime
rs1056996 -- 62,905,323(-) TCACA(C/T)GCTAC intron-variant, utr-variant-3-prime
rs10583836 -- 62,882,938(+) TTTTT(-/TTT)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DIDO1 Gene

Variant ID Type Subtype PubMed ID
esv32958 CNV loss 17666407
nsv428380 CNV loss 18775914
nsv459069 CNV gain 19166990
nsv475456 CNV novel sequence insertion 20440878
nsv586532 CNV gain 21841781
nsv828794 CNV loss 20364138
nsv9825 CNV gain 18304495

Variation tolerance for DIDO1 Gene

Residual Variation Intolerance Score: 4.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DIDO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DIDO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DIDO1 Gene

Disorders for DIDO1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DIDO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal adenoma
  • adenoma of large intestine
- elite association - COSMIC cancer census association via MalaCards
Search DIDO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DIDO1

Genetic Association Database (GAD)
DIDO1
Human Genome Epidemiology (HuGE) Navigator
DIDO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DIDO1
genes like me logo Genes that share disorders with DIDO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DIDO1 Gene

Publications for DIDO1 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  2. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64

Products for DIDO1 Gene

Sources for DIDO1 Gene

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