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Aliases for DICER1 Gene

Aliases for DICER1 Gene

  • Dicer 1, Ribonuclease Type III 2 3
  • HERNA 3 4 6
  • Helicase MOI 3 4
  • EC 3.1.26.3 4 63
  • KIAA0928 4 6
  • Dicer 3 4
  • RMSE2 3 6
  • MNG1 3 6
  • Dicer 1, Double-Stranded RNA-Specific Endoribonuclease 3
  • Double-Stranded RNA-Specific Endoribonuclease 2
  • Dicer1, Dcr-1 Homolog (Drosophila) 2
  • Helicase With RNAse Motif 3
  • Helicase With RNase Motif 4
  • Endoribonuclease Dicer 3
  • Multinodular Goitre 1 2
  • Dicer1, Dcr-1 Homolog 3
  • K12H4.8-LIKE 3
  • EC 3.1.26 63
  • Dicer 1 2
  • Dicer1e 3
  • DCR1 3

External Ids for DICER1 Gene

Previous HGNC Symbols for DICER1 Gene

  • MNG1

Previous GeneCards Identifiers for DICER1 Gene

  • GC14M093065
  • GC14M089372
  • GC14M093542
  • GC14M094622
  • GC14M095552
  • GC14M075736

Summaries for DICER1 Gene

Entrez Gene Summary for DICER1 Gene

  • This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for DICER1 Gene

DICER1 (Dicer 1, Ribonuclease Type III) is a Protein Coding gene. Diseases associated with DICER1 include pleuropulmonary blastoma and goiter, multinodular 1, with or without sertoli-leydig cell tumors. Among its related pathways are MicroRNAs in cancer and Translational Control. GO annotations related to this gene include ATP-dependent helicase activity and miRNA binding. An important paralog of this gene is DDX58.

UniProtKB/Swiss-Prot for DICER1 Gene

  • Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3 overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Gene Wiki entry for DICER1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DICER1 Gene

Genomics for DICER1 Gene

Regulatory Elements for DICER1 Gene

Transcription factor binding sites by QIAGEN in the DICER1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DICER1 Gene

Start:
95,086,228 bp from pter
End:
95,158,010 bp from pter
Size:
71,783 bases
Orientation:
Minus strand

Genomic View for DICER1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DICER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DICER1 Gene

Proteins for DICER1 Gene

  • Protein details for DICER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY3-DICER_HUMAN
    Recommended name:
    Endoribonuclease Dicer
    Protein Accession:
    Q9UPY3
    Secondary Accessions:
    • A7E2D3
    • B3KRG4
    • E0AD28
    • O95943
    • Q9UQ02

    Protein attributes for DICER1 Gene

    Size:
    1922 amino acids
    Molecular mass:
    218682 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    • Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D.
    SequenceCaution:
    • Sequence=CAB38857.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DICER1 Gene

    Alternative splice isoforms for DICER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DICER1 Gene

Proteomics data for DICER1 Gene at MOPED

Post-translational modifications for DICER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DICER1 (Dicer1)

Domains for DICER1 Gene

Suggested Antigen Peptide Sequences for DICER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPY3

UniProtKB/Swiss-Prot:

DICER_HUMAN :
  • Q9UPY3
Domain:
  • Contains 1 Dicer dsRNA-binding fold domain.
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 PAZ domain.
  • Contains 2 RNase III domains.
Family:
  • Belongs to the helicase family. Dicer subfamily.
genes like me logo Genes that share domains with DICER1: view

No data available for Gene Families for DICER1 Gene

Function for DICER1 Gene

Molecular function for DICER1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage to 5-phosphomonoester.
UniProtKB/Swiss-Prot Function: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3 overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Enzyme Numbers (IUBMB) for DICER1 Gene

Gene Ontology (GO) - Molecular Function for DICER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IMP 19701182
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DICER1: view
genes like me logo Genes that share phenotypes with DICER1: view

Animal Models for DICER1 Gene

MGI Knock Outs for DICER1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DICER1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DICER1 Gene

Localization for DICER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DICER1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DICER1 Gene COMPARTMENTS Subcellular localization image for DICER1 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DICER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005829 cytosol TAS --
GO:0016442 NOT RISC complex IDA 16357216
genes like me logo Genes that share ontologies with DICER1: view

Pathways for DICER1 Gene

genes like me logo Genes that share pathways with DICER1: view

Pathways by source for DICER1 Gene

1 Qiagen pathway for DICER1 Gene
1 Cell Signaling Technology pathway for DICER1 Gene
1 BioSystems pathway for DICER1 Gene

Gene Ontology (GO) - Biological Process for DICER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001525 angiogenesis IEA --
GO:0001942 hair follicle development --
GO:0006309 apoptotic DNA fragmentation IBA --
GO:0006396 RNA processing --
genes like me logo Genes that share ontologies with DICER1: view

Transcripts for DICER1 Gene

Unigene Clusters for DICER1 Gene

Dicer 1, ribonuclease type III:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DICER1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DICER1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DICER1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: -
SP2: - - - - - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10: -
SP11:
SP12:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DICER1 Gene

GeneLoc Exon Structure for
DICER1
ECgene alternative splicing isoforms for
DICER1

Expression for DICER1 Gene

mRNA expression in normal human tissues for DICER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DICER1 Gene

SOURCE GeneReport for Unigene cluster for DICER1 Gene Hs.87889

genes like me logo Genes that share expressions with DICER1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DICER1 Gene

Orthologs for DICER1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DICER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DICER1 35
  • 99.79 (n)
  • 99.9 (a)
DICER1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DICER1 35
  • 91.9 (n)
  • 95.99 (a)
DICER1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DICER1 35
  • 93.89 (n)
  • 96.93 (a)
DICER1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dicer1 35
  • 89.05 (n)
  • 93.12 (a)
Dicer1 16
Dicer1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DICER1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DICER1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dicer1 35
  • 89.18 (n)
  • 93.11 (a)
chicken
(Gallus gallus)
Aves DICER1 35
  • 86.42 (n)
  • 92.14 (a)
DICER1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DICER1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dicer1 35
  • 78.05 (n)
  • 84.41 (a)
zebrafish
(Danio rerio)
Actinopterygii dicer1 35
  • 72.57 (n)
  • 82.33 (a)
dicer1 36
  • 81 (a)
OneToOne
wufc39d11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002836 35
  • 49.6 (n)
  • 45.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dcr-1 35
  • 49.62 (n)
  • 45.96 (a)
Dcr-1 36
  • 33 (a)
OneToOne
Dcr-2 37
  • 25 (a)
Dcr-1 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea dcr-1 35
  • 50.05 (n)
  • 43.83 (a)
dcr-1 36
  • 34 (a)
OneToOne
dcr-1 37
  • 34 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08270 35
  • 42.71 (n)
  • 31.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dcr1 35
  • 47.21 (n)
  • 34.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14057 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for DICER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DICER1 Gene

ENSEMBL:
Gene Tree for DICER1 (if available)
TreeFam:
Gene Tree for DICER1 (if available)

Paralogs for DICER1 Gene

Paralogs for DICER1 Gene

Selected SIMAP similar genes for DICER1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DICER1 Gene

genes like me logo Genes that share paralogs with DICER1: view

Variants for DICER1 Gene

Sequence variations from dbSNP and Humsavar for DICER1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13078 -- 95,090,410(+) CACTA(A/T)CAACT utr-variant-3-prime
rs1006157 -- 95,094,288(+) AAAGG(A/G)TATCT intron-variant
rs1057035 -- 95,087,805(+) ACACG(C/T)GCTCA utr-variant-3-prime
rs1063608 -- 95,090,047(-) TAGTT(A/G)ATAAG utr-variant-3-prime
rs1063609 -- 95,090,034(-) GAATA(A/G)AAAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DICER1 Gene

Variant ID Type Subtype PubMed ID
nsv84515 CNV Loss 16902084

Relevant External Links for DICER1 Gene

HapMap Linkage Disequilibrium report
DICER1
Human Gene Mutation Database (HGMD)
DICER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DICER1 Gene

Disorders for DICER1 Gene

(3) OMIM Diseases for DICER1 Gene (606241)

UniProtKB/Swiss-Prot

DICER_HUMAN
  • Pleuropulmonary blastoma (PPB) [MIM:601200]: A rare pediatric intrathoracic neoplasm. The tumor arises from the lung, pleura, or both, and appears to be purely mesenchymal in phenotype. It lacks malignant epithelial elements, a feature that distinguishes it from the classic adult-type pulmonary blastoma. It arises during fetal lung development and is often part of an inherited cancer syndrome. The tumor contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Some patients have multilocular cystic nephroma, a benign kidney tumor. {ECO:0000269 PubMed:19556464}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1) [MIM:138800]: A common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell tumors, usually of the ovary. {ECO:0000269 PubMed:21205968}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Rhabdomyosarcoma, embryonal, 2 (RMSE2) [MIM:180295]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive neuroectodermal tumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (PubMed:21882293). Somatic missense mutations affecting the RNase IIIb domain of DICER1 are common in non-epithelial ovarian tumors. These mutations do not abolish DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation of microRNA processing may be oncogenic (PubMed:22187960). {ECO:0000269 PubMed:21882293, ECO:0000269 PubMed:22187960}.

(3) University of Copenhagen DISEASES for DICER1 Gene

Relevant External Links for DICER1

Genetic Association Database (GAD)
DICER1
Human Genome Epidemiology (HuGE) Navigator
DICER1
genes like me logo Genes that share disorders with DICER1: view

Publications for DICER1 Gene

  1. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. (PMID: 14749716) Tahbaz N. … Hobman T.C. (EMBO Rep. 2004) 3 4 23
  2. A human, ATP-independent, RISC assembly machine fueled by pre- miRNA. (PMID: 16357216) Maniataki E. … Mourelatos Z. (Genes Dev. 2005) 3 4 23
  3. The role of PACT in the RNA silencing pathway. (PMID: 16424907) Lee Y. … Kim V.N. (EMBO J. 2006) 3 4 23
  4. DICER1 mutations in familial pleuropulmonary blastoma. (PMID: 19556464) Hill D.A. … Goodfellow P.J. (Science 2009) 3 4 23
  5. Interaction of 5-lipoxygenase with cellular proteins. (PMID: 10051563) Provost P. … Radmark O. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4

Products for DICER1 Gene

Sources for DICER1 Gene

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