DICER1 Gene
protein-coding GIFtS: 65
GCID: GC14M095552
|
|
dicer 1, ribonuclease type III(Previous names: Dicer1, Dcr-1 homolog (Drosophila) )
| |
Aliases
for DICER1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dicer 1, Ribonuclease Type III1 2 | | MNG12 | | HERNA1 2 3 5 | | Dicer 1, Double-Stranded RNA-Specific Endoribonuclease2 | | KIAA09281 3 5 | | Dicer1, Dcr-1 Homolog2 | | Dicer1 2 | | Endoribonuclease Dicer2 | | K12H4.8-LIKE1 2 | | Helicase-Moi1 | | Helicase MOI2 3 | | DICER3 | | Helicase With RNase Motif2 3 | | EC 3.1.26.-3 | | Dicer1, Dcr-1 Homolog (Drosophila)1 | | EC 3.1.268 | | DCR12 | | EC 3.1.26.38 |
Export aliases for DICER1 gene to outside databasesPrevious GC identifers: GC14M093065 GC14M089372 GC14M093542 GC14M094622 GC14M075736 |
Summaries
for DICER1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DICER1:
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNAmotif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interferenceand small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression.Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2010)
UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex(RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 andTARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAsand then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and maysubsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs(siRNAs) which target the selective destruction of complementary RNAs
Gene Wiki entry for DICER1
|
Genomic Views
for DICER1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DICER1 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for DICER1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DICER1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.13 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32.13DICER1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M095552: view genomic region
(about GC identifiers)
Start:
|
95,552,565 bp from pter |
End:
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95,624,347 bp from pter |
Size:
|
71,783 bases |
Orientation:
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minus strand |
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Proteins
for DICER1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3 (See
protein sequence)Recommended Name: Endoribonuclease Dicer Size: 1922 amino acids; 218682 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (Probable)
Subunit: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composedof DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9,EIF2C1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D
Subcellular location: Cytoplasm
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=CAB38857.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for DICER1:2EB1 (3D)
Secondary accessions: A7E2D3 E0AD28 O95943 Q9UQ02Alternative splicing: 2 isoforms: Q9UPY3-1 Q9UPY3-2 Explore the universe of human proteins at neXtProt for DICER1: NX_Q9UPY3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPY3
4/52 DME Specific Peptides for DICER1 (Q9UPY3) (see all 52)
DICER1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001182502.1 NP_085124.2 NP_803187.1 NP_001258211.1
ENSEMBL proteins: ENSP00000343745 ENSP00000437256 ENSP00000435681 ENSP00000451041 ENSP00000452556 ENSP00000433060 ENSP00000433926 ENSP00000433384 ENSP00000376783 ENSP00000444719 Reactome Protein details: Q9UPY3
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
DICER1 for ontologies About GeneDecksing
DICER1 Antibody Products:
Assay Products for DICER1: |
Protein
Domains /
Families
for DICER1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DICER1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9UPY3ProtoNet protein and cluster: Q9UPY3 4 Blocks protein families: IPB000999 Ribonuclease III family IPB001159 Double-stranded RNA binding (DsRBD) domain IPB003100 Argonaute and Dicer protein IPB005034 Protein of unknown function DUF283
UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3Similarity: Belongs to the helicase family. Dicer subfamilySimilarity: Contains 1 Dicer dsRNA-binding fold domainSimilarity: Contains 1 DRBM (double-stranded RNA-binding) domainSimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domainSimilarity: Contains 1 PAZ domainSimilarity: Contains 2 RNase III domains |
Function
for DICER1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex(RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 andTARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAsand then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and maysubsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs(siRNAs) which target the selective destruction of complementary RNAsEnzyme Numbers (IUBMB): EC 3.1.26.32 EC 3.1.26.-1 EC 3.1.262
miRNA
Products: | | miRTarBase miRNAs that target DICER1:
hsa-mir-107 (MIRT005348), hsa-mir-519a (MIRT005571), hsa-mir-154 (MIRT005679), hsa-mir-374a (MIRT005572), hsa-let-7a (MIRT004346), hsa-let-7c (MIRT004348), ebv-mir-bart6-5p (MIRT004758), hsa-let-7b (MIRT005322), hsa-mir-103 (MIRT005347), hsa-let-7d (MIRT004347) |
| |  | OriGene 3'-UTR Clone (see all 2): DICER1
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DICER1 | | | 8/153 QIAGEN miScript miRNA Assays for microRNAs that regulate DICER1 (see all 153): | | | hsa-miR-411* hsa-miR-640 hsa-miR-519a hsa-miR-298 hsa-miR-642b hsa-miR-130b hsa-miR-519e hsa-let-7e | | | | |  | SwitchGear 3'UTR luciferase reporter plasmids (see all 2): DICER1 3' UTR sequence |
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DICER1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DICER1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DICER1 (NM_177438) | |  | Sino Biological Human cDNA Clone for DICER1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DICER1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DICER1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DICER1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
DICER1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DICER1:
Animal Models:
Mouse knock-outs for DICER1: Dicer1tm1Ghan Dicer1tm1.1Mmk Dicer1tm1.2Mnn Dicer1tm1Gz Dicer1tm1.1Snj Dicer1tm1.1Bdh
15/22 MGI mutant phenotypes (inferred from 15 alleles ) (MGI details for Dicer1) (see all 22):
DICER1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DICER1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Duplex siRNA is loaded into Argonaute | | | 2 | Regulatory RNA pathways | | | 3 | Translational Control | | | 4 | mRNA Splicing - Major Pathway | | | 5 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DICER1
1 
Cell Signaling Technology (CST) Pathway for DICER1
1  BioSystems Pathway for DICER1
5/6 
Reactome Pathways for DICER1 (see all 6)
DICER1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DICER1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/204 Interacting proteins for DICER1 (Q9UPY31, 2, 3 ENSP000003437454) via UniProtKB, MINT, STRING, and/or I2D (see all 204)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TARBP2 | Q156331, 2, 3, ENSP000002669874 | EBI-395506,EBI-978581 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 I2D:
score=7 STRING: ENSP00000266987 | | AGO2 | Q9UKV81, 2, 3, ENSP000002205924 | EBI-395506,EBI-528269 MINT-6489217 MINT-6489539 I2D:
score=6 STRING: ENSP00000220592 | | AGO1 | Q9UL181, 2, 3, ENSP000003623004 | EBI-395506,EBI-527363 MINT-6488488 MINT-6488791 I2D:
score=3 STRING: ENSP00000362300 | | EIF2C2 | Q9UKV81, 2, 3 | EBI-395506,EBI-528269 MINT-6489217 MINT-6489539 I2D:
score=6 | | EIF2C1 | Q9UL181, 2, 3 | EBI-395506,EBI-527363 MINT-6488488 MINT-6488791 I2D:
score=3 |
About this table
Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0001525 | angiogenesis |
IEA | -- | | GO:0001942 | hair follicle development |
-- | -- | | GO:0006396 | RNA processing |
-- | -- | | GO:0006915 | apoptotic process |
IEA | -- |
DICER1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DICER1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DICER1
Search CenterWatch for drugs/clinical trials and news about DICER1 / DICER
|
Transcripts
for DICER1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DICER1 gene (4 alternative transcripts): NM_001195573.1 NM_030621.3 NM_177438.2 NM_001271282.1 Unigene Cluster for DICER1: Dicer 1, ribonuclease type III Hs.87889 [show with all ESTs]Unigene Representative Sequence: NM_17743817 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000343455(uc010avh.1 uc021sbc.1 uc001ydv.2 uc001ydx.2 uc001yeb.1 uc001ydz.1)
ENST00000526495(uc001ydw.2 uc001yec.1) ENST00000527416 ENST00000527414
ENST00000556045(uc001ydy.1) ENST00000527554 ENST00000532939 ENST00000554367
ENST00000556681 ENST00000529468 ENST00000532458 ENST00000529206 ENST00000531162(uc001yea.1)
ENST00000529720 ENST00000527865 ENST00000393063 ENST00000541352(uc021sbd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DICER1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DICER1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): DICER1 (NM_177438) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DICER1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DICER1 |
Additional cDNA sequence: AB023145.2 AB028449.1 AF007142.1 AJ132261.2 AK001041.1 AK001827.1 AK002007.1 AK091094.1 AK091513.1 AL122105.1 AL832389.1 AY845867.1 AY929254.1 AY929255.1 AY929256.1 BC046934.1 BC068591.1 BC150287.1 HM595745.1 14 DOTS entries: DT.317718 DT.95252847 DT.100816980 DT.97763171 DT.91823640 DT.95295120 DT.95266523 DT.40293064 DT.95182023 DT.120779673 DT.97823900 DT.100816977 DT.120779731 DT.99951130 24/320 AceView cDNA sequences (see all 320): BQ029993 AA977929 BU507638 BM848399 BQ188480 AI249382 AA976871 AI268132 F12643 BM713337 BI712506 AL122105 AB023145 F08007 AI969443 AA296802 AU119024 AW193662 NM_177438 AA987461 BM692875 AV660624 AA743316 AW339969
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DICER1 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28a | · | 28b | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | ^ | 32 |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | |
| SP2: | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DICER1
|
Expression
for DICER1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DICER1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCAGAAAT
About this image
See DICER1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DICER1
SOURCE GeneReport for Unigene cluster: Hs.87889
SABiosciences Custom PCR Arrays for DICER1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DICER1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DICER1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DICER1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DICER1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DICER1 |
Orthologs
for DICER1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DICER1 gene from 9/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Dicer11 , 5 |
Dicer1, Dcr-1 homolog (Drosophila)5
dicer 1, ribonuclease type III1 |
89.22(n)1
93.28(a)1 |
|
12 (54.83 cM)5
1921191 NM_148948.21 NP_683750.21
1046877425 |
chicken
(Gallus gallus) |
Aves |
DICER11 |
dicer 1, ribonuclease type III |
86.42(n)
92.14(a) |
|
423437 NM_001040465.1 NP_001035555.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DICER16 |
-- |
90(a) |
1 ↔ 1 |
1(6896035-6935932) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ085417.12 |
-- |
85.32(n) |
|
BJ085417.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc39d112 |
Danio rerio Dicer1 (dicer1) mRNA, partial cds |
78.33(n) |
|
AY386319.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Dcr-13 |
RNA interference double-stranded RNA binding |
45(a)
(best of 2) |
|
94C4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
dcr-11 , 3 |
dead box helicase3
Protein DCR-11 |
34(a)3
49.8(n)1
43.74(a)1 |
|
III(8143853-8152017)3
1761381 NM_066360.21 NP_498761.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
DCL21 |
protein dicer-like 2 |
46.24(n)
36.79(a) |
|
821300 NM_001202869.1 NP_001189798.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g05839001 |
hypothetical protein |
44.24(n)
34.17(a) |
|
4333337 NM_001057099.1 NP_001050564.1 |
ENSEMBL Gene Tree for DICER1 (if available)
TreeFam Gene Tree for DICER1 (if available) |
Paralogs
for DICER1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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| Paralogs for DICER1 gene
- IFIH12 DHX582 DDX582
1 SIMAP similar gene for DICER1 using alignment to 5 protein entries: DICER_HUMAN (see all proteins):DKFZp434A0427
DICER1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DICER1
PGOHUM00000235615
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Genomic Variants
for DICER1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DICER1 (95552565 - 95624347 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for DICER1
7 CNVs: 76711 5766 87334 76712 76709 76713 76710
Human Gene Mutation Database (HGMD): DICER1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DICER1 |
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Disorders
/ Diseases
for DICER1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DICER1 for disorders About GeneDecksing
OMIM gene information: 606241
OMIM disorders: 601200
UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3
Defects in DICER1 are a cause of pleuropulmonary blastoma (PPB) [MIM:601200]. PPB is a rare pediatric tumor ofthe lung that arises during fetal lung development and is often part of an inherited cancer syndrome. PPBs containboth epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are linedwith benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cystwalls and form a dense 'cambium' layer beneath the epithelial lining. In a subset of patients, overgrowth of themesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis Defects in DICER1 are the cause of goiter multinodular type 1 with or without Sertoli-Leydig cell tumors(MNG1) [MIM:138800]. A common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals mayalso develop Sertoli-Leydig cell tumors, usually of the ovary Note=DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive neuroectodermaltumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (PubMed:21882293). Somatic missensemutations affecting the RNase IIIb domain of DICER1 are common in non-epithelial ovarian tumors. These mutations donot abolish DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation ofmicroRNA processing may be oncogenic (PubMed:22187960)
20/45  diseases for DICER1 (see all 45): About MalaCardsmonoclonal gammopathy of undetermined significance sertoli-leydig cell tumor pleuropulmonary blastoma leydig cell tumor
multinodular goiter primitive neuroectodermal tumor pulmonary sequestration fragile x syndrome
cystic nephroma blastoma neuroectodermal tumors embryonal rhabdomyosarcoma
goiter macular degeneration burkitt's lymphoma mucoepidermoid carcinoma
renal cell carcinoma wilms tumor rhabdomyosarcoma multiple myeloma
3 diseases from the University of Copenhagen DISEASES database for DICER1:Cystic nephroma Cancer Fragile X syndrome Human Genome Epidemiology (HuGE) Navigator: DICER1 (9 documents)
Export disorders for DICER1 gene to outside databases
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Publications
for DICER1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DICER1 gene, integrated from 9 sources (see all 215):
(articles sorted by number of sources associating them with DICER1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. (PubMed id 10786632)1, 2, 3 Matsuda S....Hamaguchi M. (2000)
- Interaction of 5-lipoxygenase with cellular proteins. (PubMed id 10051563)1, 2, 3 Provost P.... Radmark O. (1999)
- Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. (PubMed id 14749716)1, 2, 9 Tahbaz N....Hobman T.C. (2004)
- The role of PACT in the RNA silencing pathway. (PubMed id 16424907)1, 2, 9 Lee Y.... Kim V.N. (2006)
- DICER1 mutations in familial pleuropulmonary blastoma . (PubMed id 19556464)1, 2, 9 Hill D.A....Goodfellow P.J. (2009)
- Recurrent somatic DICER1 mutations in nonepithelial o varian cancers. (PubMed id 22187960)1, 2 Heravi-Moussavi A....Huntsman D.G. (2012)
- DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. (PubMed id 21205968)1, 2 Rio Frio T....Tischkowitz M. (2011)
- Extending the phenotypes associated with DICER1 mutations. (PubMed id 21882293)1, 2 Foulkes W.D.... Priest J.R. (2011)
- A novel splice variant of the human dicer gene is expressed in neuroblastoma cells. (PubMed id 20615407)1, 2 Potenza N.... Russo A. (2010)
- A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. (PubMed id 19219043)1, 2 Melo S.A.... Esteller M. (2009)
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External Searches for DICER1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DICER1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DICER1 gene
(According to HUGE)
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| |
Specialized Databases showing DICER1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DICER1 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt087.shtml |
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About This Section
| Patent Information for DICER1 gene:
Search GeneIP for patents involving DICER1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DICER1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for DICER1 | | OriGene shRNA RFP for DICER1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DICER1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DICER1 | | | OriGene Protein Over-expression Lysate for DICER1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DICER1 | | OriGene 3'-UTR Clone for DICER1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DICER1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DICER1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DICER1 | | OriGene Custom Protein Services for DICER1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DICER1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DICER1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DICER1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DICER1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DICER1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DICER1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DICER1 |
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