Aliases for DICER1 Gene
External Ids for DICER1 Gene
Previous HGNC Symbols for DICER1 Gene
Previous GeneCards Identifiers for DICER1 Gene
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
GeneCards Summary for DICER1 Gene
DICER1 (Dicer 1, Ribonuclease Type III) is a Protein Coding gene. Diseases associated with DICER1 include pleuropulmonary blastoma and goiter, multinodular 1, with or without sertoli-leydig cell tumors. Among its related pathways are MicroRNAs in cancer and Translational Control. GO annotations related to this gene include ATP-dependent helicase activity and miRNA binding. An important paralog of this gene is DDX58.
UniProtKB/Swiss-Prot for DICER1 Gene
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3 overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.