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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHX9 Gene

protein-coding   GIFtS: 60
GCID: GC01P182808

DEAH (Asp-Glu-Ala-His) box polypeptide 9

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase...)
(Previous symbols: LKP, DDX9)
 Explore 29 diseases affiliated with
DHX9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DHX9    

Aliases
for DHX9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 91 2     ATP-Dependent RNA Helicase A2
DDX91 2 3 5     DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 92
LKP1 2 3     Leukophysin3
RHA1 2 3     EC 3.6.4.133
Nuclear DNA Helicase II2 3     Leukophysin3
NDH22 3     NDH II3
DEAH Box Protein 92 3     EC 3.6.18
NDHII2 5     EC 3.6.1.158
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 9 (RNA Helicase A, Nuclear DNA
Helicase II; Leukophysin)1
     

External Ids:    HGNC: 27501   Entrez Gene: 16602   Ensembl: ENSG000001358297   OMIM: 6031155   UniProtKB: Q082113   
ORGUL members:         
NONCODE:n409159    

Export aliases for DHX9 gene to outside databases

Previous GC identifers: GC01P179328 GC01P180047 GC01P180029 GC01P179540 GC01P181075 GC01P154044


Summaries
for DHX9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DHX9:
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that
catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the
nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the
expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants.
Pseudogenes of this gene are found on chromosomes 11 and 13.(provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may
subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator.
Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of
type I collagen mRNAs for CO1A1 and CO1A2

Gene Wiki entry for DHX9 (RNA Helicase A)


Genomic Views
for DHX9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHX9 gene promoter:
         Tal-1   Pax-5   SREBP-1c   E47   SREBP-1b   CREB   SREBP-1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DHX9 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHX9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

DHX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P182808:  view genomic region     (about GC identifiers)

Start:
 182,808,439 bp from pter      End:
 182,857,117 bp from pter
Size:
 48,679 bases      Orientation:
 plus strand

Proteins
for DHX9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase A  
Size: 1270 amino acids; 140958 Da
Subunit: Interacts with ZIC2 (By similarity). Component of the coding region determinant (CRD)-mediated complex,
composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X,
ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule
complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP,
TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. Binds MBD2, HRMT1L2/PRMT1, and RELA. May act to directly
link BRCA1, CREBBP or SMN1 and the RNA polymerase II complex. Can also interact with XRCC5 and with TOP2A in an RNA
dependent manner; these interactions may be indirect. Interaction with TOP2A is promoted by UBC9. Interacts with
histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with LARP6
Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs. Can shuttle between nucleus and cytoplasm
3 PDB 3D structures from and Proteopedia for DHX9:
3LLM (3D)        3VYX (3D)        3VYY (3D)    
Secondary accessions: B2RNV4 Q05CI5 Q12803 Q32Q22 Q5VY62 Q6PD69 Q99556
Alternative splicing: 2 isoforms:  Q08211-1   Q08211-2   

Explore the universe of human proteins at neXtProt for DHX9: NX_Q08211

Post-translational modifications:

  • Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization1
  • May be phosphorylated by PRKDC/XRCC71
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08211

    • 4/46 DME Specific Peptides for DHX9 (Q08211) (see all 46)
     IVVTQPR  GVLLRKL  IVDEIHE  LPRPHAS 

    DHX9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001348.2  
    ENSEMBL proteins: 
     ENSP00000356520  
    Reactome Protein details: Q08211
    Human Recombinant Protein Products: 
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    Novus Biologicals DHX9 Protein
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    Uscn Proteins for DHX9

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17498979
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm TAS8690889
    GO:0005813centrosome IDA17498979


    DHX9 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DHX9

    Protein Domains /
    Families
    for DHX9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DHX9 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR007502 Helicase-assoc_dom
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR001159 Ds-RNA-bd
     IPR011709 DUF1605
     IPR002464 DNA/RNA_helicase_DEAH_CS

    Graphical View of Domain Structure for InterPro Entry Q08211

    ProtoNet protein and cluster: Q08211

    3 Blocks protein families:
    IPB001159 Double-stranded RNA binding (DsRBD) domain
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
    Domain: The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and
    sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for DHX9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
    Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may
    subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator.
    Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of
    type I collagen mRNAs for CO1A1 and CO1A2
    Catalytic activity: ATP + H(2)O = ADP + phosphate

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131 EC 3.6.1.152

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX9:
    hsa-miR-34c-3p hsa-miR-200c hsa-miR-548g hsa-miR-429 hsa-miR-34b hsa-miR-200b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: DHX9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX9 (see all 7)
    OriGene shRNA RFP: DHX9
    OriGene siRNA: DHX9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX9

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI17303075
    GO:0003677DNA binding IEA--
    GO:0003724RNA helicase activity TAS8690889
    GO:0003725double-stranded RNA binding IEA--
    GO:0004003ATP-dependent DNA helicase activity TAS9111062


    DHX9 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DHX9:
     Decreased viability  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Dhx9tm1Ehl for DHX9
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dhx9):
     cellular  embryogenesis  mortality/aging 

    DHX9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DHX9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    2Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for DHX9 
        mRNA processing

    5        Reactome Pathways for DHX9
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA



    DHX9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DHX9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/947 Interacting proteins for DHX9 (Q082111, 2, 3 ENSP000003565204) via UniProtKB, MINT, STRING, and/or I2D (see all 947)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0007623circadian rhythm IEA--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0034605cellular response to heat IEA--


    DHX9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DHX9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHX9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DHX9
    3 Novoseek chemical compound relationships for DHX9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 25.4 3 15613478 (2), 14729462 (1)
    nacl 14.2 1 10198287 (1)
    atp 10.1 7 11416126 (2), 12851713 (1), 1718963 (1)

    Search CenterWatch for drugs/clinical trials and news about DHX9 

    Transcripts
    for DHX9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DHX9 gene (2 alternative transcripts): 
    NM_001357.4  NM_030588.1  

    Unigene Cluster for DHX9:

    DEAH (Asp-Glu-Ala-His) box polypeptide 9
    Hs.191518  [show with all ESTs]
    Unigene Representative Sequence: NR_033302
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367549(uc001gps.3 uc001gpr.3 uc009wyd.3) ENST00000483416
    ENST00000479271 ENST00000477802 ENST00000490519 ENST00000474446 ENST00000485081(uc001gpt.3)
    ENST00000473076

    miRNA
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    hsa-miR-34c-3p hsa-miR-200c hsa-miR-548g hsa-miR-429 hsa-miR-34b hsa-miR-200b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: DHX9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX9 (see all 7)
    OriGene shRNA RFP: DHX9
    OriGene siRNA: DHX9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DHX9
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB451248.1 AB451372.1 AF086352.1 AK001442.1 AK130564.1 AK226102.1 AK308165.1 BC008773.1 
    BC014246.2 BC025245.1 BC032742.1 BC058896.1 BC071950.1 BC107881.1 BC137136.1 BC144494.1 
    L13848.1 NR_033302.1 U03643.1 Y10658.1 

    24/33 DOTS entries (see all 33):

    DT.97857621  DT.100037728  DT.101956398  DT.97780909  DT.100825185  DT.95152857  DT.92462616  DT.95152845 
    DT.100825188  DT.100875933  DT.95183937  DT.91703276  DT.100825183  DT.452719  DT.99930132  DT.121373055 
    DT.219389  DT.92462587  DT.95152848  DT.100825182  DT.121373013  DT.121373032  DT.121373073  DT.91830843 

    24/578 AceView cDNA sequences (see all 578):

    AI656245 BF196854 BQ883532 AA101835 AI656776 CB149767 BM982336 BM819298 
    AI015549 AU125209 BM458581 BE295797 BC008773 AL121011 BX951613 BP365217 
    CA487486 AI801763 BM832543 BX951590 AA372195 CD365170 F04928 AU117459 

    GeneLoc Exon Structure


    Expression
    for DHX9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHX9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTATGTGTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DHX9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    KidneyMetanephrosKidney
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See DHX9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHX9

    SOURCE GeneReport for Unigene cluster: Hs.191518
        SABiosciences Custom PCR Arrays for DHX9
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX9

    Orthologs
    for DHX9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DHX9 gene from 5/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DHX96
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343203.1(4633886-4667082)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.247632 Xenopus laevis transcribed sequence with moderate similarity more 76.72(n)    CA788901.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.281932 Danio rerio cDNA clone IMAGE3819779 75.49(n)    BC058323.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mle1 maleless 54.62(n)
    52.95(a)    		   35523  NM_057293.3  NP_476641.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rha-11 Protein RHA-1 52.28(n)
    44.86(a)    		   174417  NM_063489.4  NP_495890.2 


    ENSEMBL Gene Tree for DHX9 (if available)
    TreeFam Gene Tree for DHX9 (if available) 

    Paralogs
    for DHX9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHX9 gene
    DHX402  YTHDC22  DHX572  DHX352  DHX292  DHX362  DHX302  TDRD92  
    DHX332  DHX162  DHX382  DHX82  
    2 SIMAP similar genes for DHX9 using alignment to 3 protein entries:     DHX9_HUMAN (see all proteins):
    DHX36    HIG-1

    DHX9 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for DHX9
    PGOHUM00000242393 PGOHUM00000242701 PGOHUM00000248636


    Genomic Variants
    for DHX9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/802 NCBI SNPs in DHX9 are shown (see all 802)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1875568391,2
    		C,other200145517(+) AACATC/TGTAGT 3 I nc-transcript-variantsyn10--------
    rs285904271,2
    		C,F,H,--154042754(+) GGGTAC/TAAAAA 2 -- us2k14Minor allele frequency- T:0.02NS NA CSA 467
    rs357928511,2
    		C--154043253(+) CGTTAG/TCCAGG 2 -- us2k12Minor allele frequency- T:0.00NA 4
    rs285351621,2
    		C--154043725(+) ATGCCA/GGGTAT 2 -- us2k12Minor allele frequency- G:0.00NA 4
    rs762401961,2
    		F,--154043847(+) ATCCCT/CATGAC 2 -- us2k12Minor allele frequency- C:0.08WA NA 238
    rs747109711,2
    		C,F,--154044242(+) TAAGAG/ACTGGG 2 -- nc-transcript-variantut511Minor allele frequency- A:0.03WA 118
    rs761887791,2
    		F,--154044834(+) GATTAG/ATTATC 2 -- int11Minor allele frequency- A:0.06WA 118
    rs1147775741,2
    		C,F,--154045456(+) AGATAT/CTCTTT 2 -- int11Minor allele frequency- C:0.02WA 118
    rs781623291,2
    		--154045771(+) GTGAGT/GTAGTG 2 -- int12Minor allele frequency- G:0.08CSA WA 120
    rs799164311,2
    		--154045778(+) AGTGCC/TACAGT 2 -- int12Minor allele frequency- T:0.08CSA WA 120

    HapMap Linkage Disequilibrium report for DHX9 (182808439 - 182857117 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DHX9
         1 Indel: 97579

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DHX9
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX9

    Disorders / Diseases
    for DHX9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DHX9 for disorders           About GeneDecksing

    OMIM gene information: 603115    OMIM disorders: --

    20/29 diseases for DHX9 (see all 29):    About MalaCards
    high pressure neurological syndrome    human t-cell leukemia virus type 1    treacher collins syndrome    corneal edema
    werner syndrome    corneal degeneration    astigmatism    kaposi's sarcoma
    keratopathy    keratoconus    t-cell leukemia    keratitis
    rheumatoid arthritis    hepatitis c    prostate cancer    vaccinia
    sarcoma    arthritis    influenza    immunodeficiency

    3 diseases from the University of Copenhagen DISEASES database for DHX9:
    Influenza     Pseudopterygium     Keratitis

    4 Novoseek disease relationships for DHX9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    werner syndrome 69.1 4 15995249 (2), 17498979 (1)
    tumors 0 2 10918303 (1), 14729462 (1)
    cancer 0 1 14769796 (1)
    immunodeficiency 0 1 16527808 (1)

    Human Genome Epidemiology (HuGE) Navigator: DHX9 (1 document)

    Export disorders for DHX9 gene to outside databases

    Publications
    for DHX9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHX9 gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with DHX9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Domain structure of human nuclear DNA helicase II (RNA helicase A). (PubMed id 9111062)1, 2, 3, 9 Zhang S. and Grosse F. (1997)
    2. Human RNA helicase A is homologous to the maleless protein of Drosophila. (PubMed id 8344961)1, 2, 3 Lee C.-G. and Hurwitz J. (1993)
    3. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. (PubMed id 15613478)1, 2, 9 Mischo H.E.... Zhang S. (2005)
    4. Dual roles of RNA helicase A in CREB-dependent transcription. (PubMed id 11416126)1, 2, 9 Aratani S.... Nakajima T. (2001)
    5. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. (PubMed id 14704337)1, 2, 9 Zhang S.... Grosse F. (2004)
    6. RNA helicase A interacts with dsDNA and topoisomerase IIalpha. (PubMed id 12711669)1, 2, 9 Zhou K.... Lee C.-G. (2003)
    7. Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles. (PubMed id 8690889)1, 2, 9 Abdelhaleem M.M....Greenberg A.H. (1996)
    8. A functional interaction between the survival motor neuron complex and RNA polymerase II. (PubMed id 11149922)1, 2, 9 Pellizzoni L.... Dreyfuss G. (2001)
    9. Arginine methylation of RNA helicase a determines its subcellular localization. (PubMed id 15084609)1, 2, 9 Smith W.A.... David M. (2004)
    10. Antithetic effects of MBD2a on gene regulation. (PubMed id 12665568)1, 2, 9 Fujita H.... Nakajima T. (2003)

    External Searches for DHX9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DHX9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1660 HGNC: 2750 AceView: DHX9 Ensembl:ENSG00000135829 euGenes: HUgn1660
    ECgene: DHX9 H-InvDB: DHX9

    Other Databases showing DHX9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DHX9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHX9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DHX9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DHX9 gene:
    Search GeneIP for patents involving DHX9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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