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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DHX9 Gene

protein-coding GIFtS: 60
GCID: GC01P182808

DEAH (Asp-Glu-Ala-His) box polypeptide 9

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase...)
(Previous symbols: LKP, DDX9)

Explore 29 diseases affiliated with
DHX9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 9¹ ²		ATP-Dependent RNA Helicase A²
DDX9¹ ² ³ ⁵		DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 9²
LKP¹ ² ³		Leukophysin³
RHA¹ ² ³		EC 3.6.4.13³
Nuclear DNA Helicase II² ³		Leukophysin³
NDH2² ³		NDH II³
DEAH Box Protein 9² ³		EC 3.6.1⁸
NDHII² ⁵		EC 3.6.1.15⁸
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 9 (RNA Helicase A, Nuclear DNA Helicase II; Leukophysin)¹

External Ids:	HGNC: 2750¹	Entrez Gene: 1660²	Ensembl: ENSG00000135829⁷	OMIM: 603115⁵	UniProtKB: Q08211³

ORGUL members:
	NONCODE:n409159

Export aliases for DHX9 gene to outside databases

Previous GC identifers: GC01P179328 GC01P180047 GC01P180029 GC01P179540 GC01P181075 GC01P154044

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX9:

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that

catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the

nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the

expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants.

Pseudogenes of this gene are found on chromosomes 11 and 13.(provided by RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211

Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may

subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator.

Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of

type I collagen mRNAs for CO1A1 and CO1A2

Gene Wiki entry for DHX9 (RNA Helicase A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DHX9 gene promoter:
Tal-1 Pax-5 SREBP-1c E47 SREBP-1b CREB SREBP-1a deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DHX9 promoter sequence

Search SABiosciences Chromatin IP Primers for DHX9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25

DHX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX9 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P182808: view genomic region (about GC identifiers)

Start:	182,808,439 bp from pter	End:	182,857,117 bp from pter
Size:	48,679 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211 (See protein sequence)

Recommended Name: ATP-dependent RNA helicase A

Size: 1270 amino acids; 140958 Da

Subunit: Interacts with ZIC2 (By similarity). Component of the coding region determinant (CRD)-mediated complex,

composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X,

ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule

complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,

HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP,

TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. Binds MBD2, HRMT1L2/PRMT1, and RELA. May act to directly

link BRCA1, CREBBP or SMN1 and the RNA polymerase II complex. Can also interact with XRCC5 and with TOP2A in an RNA

dependent manner; these interactions may be indirect. Interaction with TOP2A is promoted by UBC9. Interacts with

histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with LARP6

Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing

untranslated mRNAs. Can shuttle between nucleus and cytoplasm

3 PDB 3D structures from and Proteopedia for DHX9:

3LLM (3D)

3VYX (3D)

3VYY (3D)

Secondary accessions: B2RNV4 Q05CI5 Q12803 Q32Q22 Q5VY62 Q6PD69 Q99556

Alternative splicing: 2 isoforms: Q08211-1 Q08211-2

Explore the universe of human proteins at neXtProt for DHX9: NX_Q08211

Post-translational modifications:

Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization¹

May be phosphorylated by PRKDC/XRCC7¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q08211

4/46 DME Specific Peptides for DHX9 (Q08211) (see all 46)

IVVTQPR

GVLLRKL

IVDEIHE

LPRPHAS

DHX9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001348.2

ENSEMBL proteins:

ENSP00000356520

Reactome Protein details: Q08211
Human Recombinant Protein Products for DHX9:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DHX9

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17498979
GO:0005654	nucleoplasm	TAS	--
GO:0005730	nucleolus	IEA	--
GO:0005737	cytoplasm	TAS	8690889
GO:0005813	centrosome	IDA	17498979

DHX9 for ontologies About GeneDecksing

DHX9 Antibody Products:

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	ThermoFisher Antibodies for DHX9

Assay Products for DHX9:

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	Uscn ELISAs and CLIAs for DHX9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DHX9 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR007502 Helicase-assoc_dom

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

IPR001159 Ds-RNA-bd

IPR011709 DUF1605

IPR002464 DNA/RNA_helicase_DEAH_CS

Graphical View of Domain Structure for InterPro Entry Q08211

ProtoNet protein and cluster: Q08211

3 Blocks protein families:

IPB001159 Double-stranded RNA binding (DsRBD) domain

IPB002464 ATP-dependent helicase

IPB007502 Helicase-associated region

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211

Domain: The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and

sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1

Similarity: Belongs to the DEAD box helicase family. DEAH subfamily

Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DHX9_HUMAN, Q08211

Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may

subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator.

Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of

type I collagen mRNAs for CO1A1 and CO1A2

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹ EC 3.6.1.15²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001085	RNA polymerase II transcription factor binding	IPI	17303075
GO:0003677	DNA binding	IEA	--
GO:0003724	RNA helicase activity	TAS	8690889
GO:0003725	double-stranded RNA binding	IEA	--
GO:0004003	ATP-dependent DNA helicase activity	TAS	9111062

DHX9 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for DHX9:

Decreased viability

Synthetic lethal with Ras

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dhx9):

cellular

embryogenesis

mortality/aging

DHX9 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Dhx9^tm1Ehl for DHX9

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DHX9

miRNA Products:		OriGene 3'-UTR Clone: DHX9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX9
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX9:
		hsa-miR-34c-3p hsa-miR-200c hsa-miR-548g hsa-miR-429 hsa-miR-34b hsa-miR-200b hsa-miR-3148
		SwitchGear 3'UTR luciferase reporter plasmid: DHX9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DHX9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DHX9 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX9

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for DHX9

mRNA processing

5 Reactome Pathways for DHX9

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

DHX9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DHX9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/947 Interacting proteins for DHX9 (Q08211^{1, 2, 3} ENSP00000356520⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 947)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³	I2D: score=1
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0007623	circadian rhythm	IEA	--
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--
GO:0034605	cellular response to heat	IEA	--

DHX9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DHX9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DHX9
3 Novoseek chemical compound relationships for DHX9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
actinomycin d	25.4	3	15613478 (2), 14729462 (1)
nacl	14.2	1	10198287 (1)
atp	10.1	7	11416126 (2), 12851713 (1), 1718963 (1)

Search CenterWatch for drugs/clinical trials and news about DHX9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DHX9 gene (2 alternative transcripts):

NM_001357.4 NM_030588.1

Unigene Cluster for DHX9:

DEAH (Asp-Glu-Ala-His) box polypeptide 9

Hs.191518 [show with all ESTs]

Unigene Representative Sequence: NR_033302

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367549(uc001gps.3 uc001gpr.3 uc009wyd.3) ENST00000483416

ENST00000479271 ENST00000477802 ENST00000490519 ENST00000474446 ENST00000485081(uc001gpt.3)

ENST00000473076

miRNA Products:		OriGene 3'-UTR Clone: DHX9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX9
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX9:
		hsa-miR-34c-3p hsa-miR-200c hsa-miR-548g hsa-miR-429 hsa-miR-34b hsa-miR-200b hsa-miR-3148
		SwitchGear 3'UTR luciferase reporter plasmid: DHX9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DHX9 (see all 7) OriGene shRNA RFP: DHX9 OriGene siRNA: DHX9
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		Sirion Biotech Custom design and validation of potent shRNA sequences against DHX9

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Additional cDNA sequence:

AB451248.1 AB451372.1 AF086352.1 AK001442.1 AK130564.1 AK226102.1 AK308165.1 BC008773.1

BC014246.2 BC025245.1 BC032742.1 BC058896.1 BC071950.1 BC107881.1 BC137136.1 BC144494.1

L13848.1 NR_033302.1 U03643.1 Y10658.1

24/33 DOTS entries (see all 33):

DT.97857621 DT.100037728 DT.101956398 DT.97780909 DT.100825185 DT.95152857 DT.92462616 DT.95152845

DT.100825188 DT.100875933 DT.95183937 DT.91703276 DT.100825183 DT.452719 DT.99930132 DT.121373055

DT.219389 DT.92462587 DT.95152848 DT.100825182 DT.121373013 DT.121373032 DT.121373073 DT.91830843

24/578 AceView cDNA sequences (see all 578):

AI656245 BF196854 BQ883532 AA101835 AI656776 CB149767 BM982336 BM819298

AI015549 AU125209 BM458581 BE295797 BC008773 AL121011 BX951613 BP365217

CA487486 AI801763 BM832543 BX951590 AA372195 CD365170 F04928 AU117459

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DHX9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATGTGTTA

About this image

DHX9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Eye

Gut Tube

Kidney

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See DHX9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DHX9

SOURCE GeneReport for Unigene cluster: Hs.191518

SABiosciences Custom PCR Arrays for DHX9

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX9

In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DHX9 gene from 5/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	DHX9⁶	--	82(a)	1 ↔ 1	GL343203.1(4633886-4667082)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24763²	Xenopus laevis transcribed sequence with moderate similarity more	76.72(n)		CA788901.1
zebrafish (Danio rerio)	Actinopterygii	Dr.28193²	Danio rerio cDNA clone IMAGE3819779	75.49(n)		BC058323.1
fruit fly (Drosophila melanogaster)	Insecta	mle¹	maleless	54.62(n) 52.95(a)		35523 NM_057293.3 NP_476641.1
worm (Caenorhabditis elegans)	Secernentea	rha-1¹	Protein RHA-1	52.28(n) 44.86(a)		174417 NM_063489.4 NP_495890.2

ENSEMBL Gene Tree for DHX9 (if available)
TreeFam Gene Tree for DHX9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DHX9 gene

DHX40² YTHDC2² DHX57² DHX35² DHX29² DHX36² DHX30² TDRD9²

DHX33² DHX16² DHX38² DHX8²

2 SIMAP similar genes for DHX9 using alignment to 3 protein entries: DHX9_HUMAN (see all proteins):

DHX36 HIG-1

DHX9 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for DHX9
PGOHUM00000242393 PGOHUM00000242701 PGOHUM00000248636

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187556839^1,2	C	other	200145517(+)	`AACATC/TGTAGT`	3	I	nc-transcript-variantsyn¹		0	--	--	--	--
rs28590427^1,2	C,F,H	--	154042754(+)	`GGGTAC/TAAAAA`	2	--	us2k¹		4		NS NA CSA	467
rs35792851^1,2	C	--	154043253(+)	`CGTTAG/TCCAGG`	2	--	us2k¹		2		NA	4
rs28535162^1,2	C	--	154043725(+)	`ATGCCA/GGGTAT`	2	--	us2k¹		2		NA	4
rs76240196^1,2	F	--	154043847(+)	`ATCCCT/CATGAC`	2	--	us2k¹		2		WA NA	238
rs74710971^1,2	C,F	--	154044242(+)	`TAAGAG/ACTGGG`	2	--	nc-transcript-variantut5¹		1		WA	118
rs76188779^1,2	F	--	154044834(+)	`GATTAG/ATTATC`	2	--	int¹		1		WA	118
rs114777574^1,2	C,F	--	154045456(+)	`AGATAT/CTCTTT`	2	--	int¹		1		WA	118
rs78162329^1,2		--	154045771(+)	`GTGAGT/GTAGTG`	2	--	int¹		2		CSA WA	120
rs79916431^1,2		--	154045778(+)	`AGTGCC/TACAGT`	2	--	int¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for DHX9 (182808439 - 182857117 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DHX9
1 Indel: 97579

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DHX9 for disorders           About GeneDecksing

OMIM gene information: 603115    OMIM disorders: --

20/29 diseases for DHX9 (see all 29):    About MalaCards

high pressure neurological syndrome human t-cell leukemia virus type 1 treacher collins syndrome corneal edema

werner syndrome corneal degeneration astigmatism kaposi's sarcoma

keratopathy keratoconus t-cell leukemia keratitis

rheumatoid arthritis hepatitis c prostate cancer vaccinia

sarcoma arthritis influenza immunodeficiency

3 diseases from the University of Copenhagen DISEASES database for DHX9:

Influenza Pseudopterygium Keratitis

4 Novoseek disease relationships for DHX9 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
werner syndrome	69.1	4	15995249 (2), 17498979 (1)
tumors	0	2	10918303 (1), 14729462 (1)
cancer	0	1	14769796 (1)
immunodeficiency	0	1	16527808 (1)

Human Genome Epidemiology (HuGE) Navigator: DHX9 (1 document)

Export disorders for DHX9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DHX9 gene, integrated from 9 sources (see all 163):
(articles sorted by number of sources associating them with DHX9)

Utopia: connect your pdf to the dynamic
world of online information

Domain structure of human nuclear DNA helicase II (RNA helicase A). (PubMed id 9111062)^{1, 2, 3, 9} Zhang S. and Grosse F. (1997)
Human RNA helicase A is homologous to the maleless protein of Drosophila. (PubMed id 8344961)^{1, 2, 3} Lee C.-G. and Hurwitz J. (1993)
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. (PubMed id 15613478)^{1, 2, 9} Mischo H.E.... Zhang S. (2005)
Dual roles of RNA helicase A in CREB-dependent transcription. (PubMed id 11416126)^{1, 2, 9} Aratani S.... Nakajima T. (2001)
DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. (PubMed id 14704337)^{1, 2, 9} Zhang S.... Grosse F. (2004)
RNA helicase A interacts with dsDNA and topoisomerase IIalpha. (PubMed id 12711669)^{1, 2, 9} Zhou K.... Lee C.-G. (2003)
Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles. (PubMed id 8690889)^{1, 2, 9} Abdelhaleem M.M....Greenberg A.H. (1996)
A functional interaction between the survival motor neuron complex and RNA polymerase II. (PubMed id 11149922)^{1, 2, 9} Pellizzoni L.... Dreyfuss G. (2001)
Arginine methylation of RNA helicase a determines its subcellular localization. (PubMed id 15084609)^{1, 2, 9} Smith W.A.... David M. (2004)
Antithetic effects of MBD2a on gene regulation. (PubMed id 12665568)^{1, 2, 9} Fujita H.... Nakajima T. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1660	HGNC: 2750	AceView: DHX9	Ensembl:ENSG00000135829	euGenes: HUgn1660
ECgene: DHX9	H-InvDB: DHX9

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DHX9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DHX9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DHX9 gene:
Search GeneIP for patents involving DHX9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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DEAH (Asp-Glu-Ala-His) box polypeptide 9

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DHX9 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 9

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