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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHX9 Gene

protein-coding   GIFtS: 62
GCID: GC01P182808

DEAH (Asp-Glu-Ala-His) Box Helicase 9

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase...)
(Previous symbols: LKP, DDX9)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DEAH (Asp-Glu-Ala-His) Box Helicase 91 2     NDHII2 5
DDX91 2 3 5     DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 9 (RNA Helicase A, Nuclear
DNA Helicase II; Leukophysin)1
LKP1 2 3     ATP-Dependent RNA Helicase A2
DEAH (Asp-Glu-Ala-His) Box Polypeptide 91 2     DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 92
NDH II1 3     leukophysin2
RNA Helicase A1 2     EC 3.6.4.133
Nuclear DNA Helicase II2 3     Leukophysin3
NDH22 3     EC 3.6.18
RHA2 3     EC 3.6.1.158
DEAH Box Protein 92 3     

External Ids:    HGNC: 27501   Entrez Gene: 16602   Ensembl: ENSG000001358297   OMIM: 6031155   UniProtKB: Q082113   
ORGUL members:         
NONCODE14:n409159      

Export aliases for DHX9 gene to outside databases

Previous GC identifers: GC01P179328 GC01P180047 GC01P180029 GC01P179540 GC01P181075 GC01P154044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX9 Gene:
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that
catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to
both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be
involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple
transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.(provided by RefSeq, Feb 2010)

GeneCards Summary for DHX9 Gene: 
DHX9 (DEAH (Asp-Glu-Ala-His) box helicase 9) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with DHX9 include pseudopterygium, and corneal degeneration, and among its related super-pathways are mRNA Processing and Immune System. GO annotations related to this gene include ATP-dependent DNA helicase activity and double-stranded RNA binding. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may
subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional
activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the
stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Positively regulates HIV-1 LTR-directed gene
expression

Gene Wiki entry for DHX9 (RNA Helicase A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHX9 gene promoter:
         Tal-1   Pax-5   SREBP-1c   E47   SREBP-1b   CREB   SREBP-1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX9 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHX9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

DHX9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P182808:  view genomic region     (about GC identifiers)

Start:
182,808,439 bp from pter      End:
182,857,117 bp from pter
Size:
48,679 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase A  
Size: 1270 amino acids; 140958 Da
Subunit: Interacts with ZIC2 (By similarity). Component of the coding region determinant (CRD)-mediated complex,
composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9,
DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP
granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL,
HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X,
RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. Binds MBD2, HRMT1L2/PRMT1, and
RELA. May act to directly link BRCA1, CREBBP or SMN1 and the RNA polymerase II complex. Can also interact with
XRCC5 and with TOP2A in an RNA dependent manner; these interactions may be indirect. Interaction with TOP2A is
promoted by UBC9. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts
with LARP6. Interacts (via N-terminus) with EIF2AK2/PKR and this interaction is dependent upon the activation of
the kinase
Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs. Can shuttle between nucleus and cytoplasm
3 PDB 3D structures from and Proteopedia for DHX9:
3LLM (3D)        3VYX (3D)        3VYY (3D)    
Secondary accessions: B2RNV4 Q05CI5 Q12803 Q32Q22 Q5VY62 Q6PD69 Q99556
Alternative splicing: 2 isoforms:  Q08211-1   Q08211-2   

Explore the universe of human proteins at neXtProt for DHX9: NX_Q08211

Explore proteomics data for DHX9 at MOPED 

Post-translational modifications:

  • UniProtKB: Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization
  • UniProtKB: May be phosphorylated by PRKDC/XRCC7. Phosphorylated by EIF2AK2/PKR and this phosphorylation perturbs its
    association with dsRNA
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08211

  • 4/46 DME Specific Peptides for DHX9 (Q08211) (see all 46)
     IVVTQPR  GVLLRKL  IVDEIHE  LPRPHAS 

    DHX9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DHX9 Protein Expression
    REFSEQ proteins: NP_001348.2  
    ENSEMBL proteins: 
     ENSP00000356520  
    Reactome Protein details: Q08211
    Human Recombinant Protein Products for DHX9: 
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    OriGene Custom MassSpec 
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    Novus Biologicals DHX9 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX9 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17498979
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm TAS8690889
    GO:0005813centrosome IDA17498979

    DHX9 for ontologies           About GeneDecksing



    DHX9 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DHX9 

    Assay Products for DHX9: 
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    Cloud-Clone Corp. CLIAs for DHX9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DHX: DEAH-boxes

    5/9 InterPro protein domains (see all 9):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR001159 Ds-RNA-bd
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR014720 dsRNA-bd-like_dom
     IPR007502 Helicase-assoc_dom

    Graphical View of Domain Structure for InterPro Entry Q08211

    ProtoNet protein and cluster: Q08211

    3 Blocks protein domains:
    IPB001159 Double-stranded RNA binding (DsRBD) domain
    IPB002464 ATP-dependent helicase
    IPB007502 Helicase-associated region


    UniProtKB/Swiss-Prot: DHX9_HUMAN, Q08211
    Domain: The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary
    and sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DHX9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX9_HUMAN, Q08211
    Function: Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may
    subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional
    activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the
    stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Positively regulates HIV-1 LTR-directed gene
    expression
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131 EC 3.6.1.152

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI17303075
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0003724RNA helicase activity TAS8690889
         
    DHX9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DHX9:
     Decreased viability  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dhx9):
     cellular  embryogenesis  mortality/aging 

    DHX9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dhx9tm1Ehl for DHX9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DHX9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHX9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX9 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX9
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX9:
    hsa-miR-34c-3p hsa-miR-200c hsa-miR-548g hsa-miR-429 hsa-miR-34b hsa-miR-200b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidDHX9 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DHX9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Generic Transcription Pathway
    Gene Expression0.47
    4Cytosolic DNA-sensing pathway
    Cytosolic sensors of pathogen-associated DNA 0.36
    5DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DHX9
        mRNA processing

    5/9        Reactome Pathways for DHX9 (see all 9)
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    mRNA Splicing - Major Pathway
    Cytosolic sensors of pathogen-associated DNA
    mRNA Splicing
    Gene Expression



    DHX9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DHX9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/981 Interacting proteins for DHX9 (Q082111, 2, 3 ENSP000003565204) via UniProtKB, MINT, STRING, and/or I2D (see all 981)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0007623circadian rhythm IEA--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--
    GO:0032481positive regulation of type I interferon production TAS--

    DHX9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHX9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DHX9

    3 Novoseek inferred chemical compound relationships for DHX9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 25.4 3 15613478 (2), 14729462 (1)
    nacl 14.2 1 10198287 (1)
    atp 10.1 7 11416126 (2), 12851713 (1), 1718963 (1)

    Search CenterWatch for drugs/clinical trials and news about DHX9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHX9 gene (2 alternative transcripts): 
    NM_001357.4  NM_030588.1  

    Unigene Cluster for DHX9:

    DEAH (Asp-Glu-Ala-His) box polypeptide 9
    Hs.191518  [show with all ESTs]
    Unigene Representative Sequence: NR_033302
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367549(uc001gps.3 uc001gpr.3 uc009wyd.3) ENST00000483416
    ENST00000479271 ENST00000477802 ENST00000490519 ENST00000474446 ENST00000485081(uc001gpt.3)
    ENST00000473076
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DHX9:
    hsa-miR-34c-3p hsa-miR-200c hsa-miR-548g hsa-miR-429 hsa-miR-34b hsa-miR-200b hsa-miR-3148
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX9
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    Additional mRNA sequence: 

    AB451248.1 AB451372.1 AF086352.1 AK001442.1 AK130564.1 AK226102.1 AK308165.1 BC008773.1 
    BC014246.2 BC025245.1 BC032742.1 BC058896.1 BC071950.1 BC107881.1 BC137136.1 BC144494.1 
    L13848.1 NR_033302.1 U03643.1 Y10658.1 

    24/33 DOTS entries (see all 33):

    DT.97857621  DT.100037728  DT.101956398  DT.97780909  DT.100825185  DT.95152857  DT.92462616  DT.95152845 
    DT.100825188  DT.100875933  DT.95183937  DT.91703276  DT.100825183  DT.452719  DT.99930132  DT.121373055 
    DT.219389  DT.92462587  DT.95152848  DT.100825182  DT.121373013  DT.121373032  DT.121373073  DT.91830843 

    24/578 AceView cDNA sequences (see all 578):

    CB149086 BE295797 AA227855 BU196461 BU683291 AI752843 BX951613 BC008773 
    AW262770 AU137966 BU631748 BM793176 AA101835 AV647243 BQ883532 BM819298 
    BF196854 BM982336 AI656245 AI656776 CB149767 AA255902 AU141379 AI015549 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHX9 expression in normal human tissues (normalized intensities)      DHX9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATGTGTTA
    DHX9 Expression
    About this image


    DHX9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             lung ; pneumocytes   
             visceral organ/lung/right lung   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See DHX9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHX9

    SOURCE GeneReport for Unigene cluster: Hs.191518
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DHX9 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx91 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 91, 5 87.27(n)1
    91.08(a)1
      1 (65.37 cM)5
    132111  NM_007842.21  NP_031868.21 
     1534557585 
    lizard
    (Anolis carolinensis)
    Reptilia DHX96
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343203.1(4632948-4667095)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247632 Xenopus laevis transcribed sequence with moderate similarity more 76.72(n)    CA788901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.281932 Danio rerio cDNA clone IMAGE3819779 75.49(n)    BC058323.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mle1 maleless 54.62(n)
    52.95(a)
      35523  NM_057293.3  NP_476641.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rha-11 Protein RHA-1 52.28(n)
    44.86(a)
      174417  NM_063489.4  NP_495890.2 


    ENSEMBL Gene Tree for DHX9 (if available)
    TreeFam Gene Tree for DHX9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHX9 gene
    DHX292  DHX302  DHX362  TDRD92  YTHDC22  DHX572  
    2 SIMAP similar genes for DHX9 using alignment to 3 protein entries:     DHX9_HUMAN (see all proteins):
    DHX36    HIG-1

    DHX9 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for DHX9
    PGOHUM00000242393 PGOHUM00000242701 PGOHUM00000248636


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1072 SNPs in DHX9 are shown (see all 1072)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875568391,2
    Cuntested1189380613(+) AACATC/TGTAGT 3 I syn10--------
    rs114650041,2
    C--182819082(+) ATATC-/AAAAAA 2 -- int10--------
    rs730630911,2
    C,F--182826129(+) ACAGGT/AGCTGC 2 -- int13Minor allele frequency- A:0.09WA CSA 121
    rs616807471,2
    C--182832928(+) TTTTT-/T/TTT 
            
    ACTGC
    3 -- int1 cds11CSA 2
    rs3716528021,2
    C--182835058(+) AGCAA-/AC/CA 
            
    CACAC
    2 -- int10--------
    rs1844511611,2
    --189357797(+) TACAGA/GCACAC 2 -- us2k10--------
    rs1888928971,2
    --189357814(+) TTGCCC/TGGCTA 2 -- us2k10--------
    rs75249111,2
    C--189357815(+) tgcccA/Ggctaa 2 -- us2k10--------
    rs1453028721,2
    --189358028(+) TCTAGC/TTTTGG 2 -- us2k10--------
    rs1509981881,2
    --189358120(+) TGAAGA/CCATCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DHX9 (182808439 - 182857117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DHX9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2537876CNV Insertion19546169

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603115    OMIM disorders: --

    20/26 diseases for DHX9 (see all 26):    About MalaCards
    pseudopterygium    corneal degeneration    high pressure neurological syndrome    corneal edema
    werner syndrome    astigmatism    keratopathy    keratitis
    keratoconus    human t-cell leukemia virus type 1    hiv type 1    vaccinia
    kaposi's sarcoma    t-cell leukemia    influenza    sarcoma
    hepatitis c    rheumatoid arthritis    tuberculosis    arthritis

    4 diseases from the University of Copenhagen DISEASES database for DHX9:
    Influenza     Pseudopterygium     Keratitis     Astigmatism

    DHX9 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for DHX9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    werner syndrome 69.1 4 15995249 (2), 17498979 (1)
    tumors 0 2 10918303 (1), 14729462 (1)
    cancer 0 1 14769796 (1)
    immunodeficiency 0 1 16527808 (1)

    Genetic Association Database (GAD): DHX9
    Human Genome Epidemiology (HuGE) Navigator: DHX9 (1 document)

    Export disorders for DHX9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHX9 gene, integrated from 9 sources (see all 178):
    (articles sorted by number of sources associating them with DHX9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Domain structure of human nuclear DNA helicase II (RNA helicase A). (PubMed id 9111062)1, 2, 3, 9 Zhang S. and Grosse F. (1997)
    2. Human RNA helicase A is homologous to the maleless protein of Drosophila. (PubMed id 8344961)1, 2, 3 Lee C.-G. and Hurwitz J. (1993)
    3. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. (PubMed id 15613478)1, 2, 9 Mischo H.E.... Zhang S. (2005)
    4. Dual roles of RNA helicase A in CREB-dependent transcription. (PubMed id 11416126)1, 2, 9 Aratani S.... Nakajima T. (2001)
    5. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. (PubMed id 14704337)1, 2, 9 Zhang S.... Grosse F. (2004)
    6. RNA helicase A interacts with dsDNA and topoisomerase IIalpha. (PubMed id 12711669)1, 2, 9 Zhou K.... Lee C.-G. (2003)
    7. Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles. (PubMed id 8690889)1, 2, 9 Abdelhaleem M.M....Greenberg A.H. (1996)
    8. A functional interaction between the survival motor neuron complex and RNA polymerase II. (PubMed id 11149922)1, 2, 9 Pellizzoni L.... Dreyfuss G. (2001)
    9. Arginine methylation of RNA helicase a determines its subcellular localization. (PubMed id 15084609)1, 2, 9 Smith W.A.... David M. (2004)
    10. Antithetic effects of MBD2a on gene regulation. (PubMed id 12665568)1, 2, 9 Fujita H.... Nakajima T. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1660 HGNC: 2750 AceView: DHX9 Ensembl:ENSG00000135829 euGenes: HUgn1660
    ECgene: DHX9 H-InvDB: DHX9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHX9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DHX9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHX9 gene:
    Search GeneIP for patents involving DHX9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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