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Aliases for DHX9 Gene

Aliases for DHX9 Gene

  • DEAH (Asp-Glu-Ala-His) Box Helicase 9 2 3
  • DDX9 3 4 6
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 9 2 3
  • Nuclear DNA Helicase II 3 4
  • DEAH Box Protein 9 3 4
  • RNA Helicase A 2 3
  • Leukophysin 3 4
  • NDH II 2 4
  • NDHII 3 6
  • NDH2 3 4
  • LKP 3 4
  • RHA 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 9 (RNA Helicase A, Nuclear DNA Helicase II; Leukophysin) 2
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 9 3
  • ATP-Dependent RNA Helicase A 3
  • EC 3.6.1.15 64
  • EC 3.6.4.13 4
  • EC 3.6.1 64

External Ids for DHX9 Gene

Previous Symbols for DHX9 Gene

  • LKP
  • DDX9

Summaries for DHX9 Gene

Entrez Gene Summary for DHX9 Gene

  • This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

GeneCards Summary for DHX9 Gene

DHX9 (DEAH (Asp-Glu-Ala-His) Box Helicase 9) is a Protein Coding gene. Diseases associated with DHX9 include pseudopterygium. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and ATP-dependent DNA helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot for DHX9 Gene

  • Unwinds double-stranded DNA and RNA in a 3 to 5 direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression.

Gene Wiki entry for DHX9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX9 Gene

Genomics for DHX9 Gene

Genomic Location for DHX9 Gene

Start:
182,839,304 bp from pter
End:
182,887,982 bp from pter
Size:
48,679 bases
Orientation:
Plus strand

Genomic View for DHX9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX9 Gene

Regulatory Elements for DHX9 Gene

Proteins for DHX9 Gene

  • Protein details for DHX9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08211-DHX9_HUMAN
    Recommended name:
    ATP-dependent RNA helicase A
    Protein Accession:
    Q08211
    Secondary Accessions:
    • B2RNV4
    • Q05CI5
    • Q12803
    • Q32Q22
    • Q5VY62
    • Q6PD69
    • Q99556

    Protein attributes for DHX9 Gene

    Size:
    1270 amino acids
    Molecular mass:
    140958 Da
    Quaternary structure:
    • Interacts with ZIC2, IGF2BP1, IGF2BP2, IGF2BP3, MBD2, HRMT1L2/PRMT1, RELA and LARP6. Can also interact with XRCC5 and with TOP2A in an RNA dependent manner; these interactions may be indirect. Interaction with TOP2A is promoted by UBC9. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on Ser-139. Interacts (via N-terminus) with EIF2AK2/PKR and this interaction is dependent upon the activation of the kinase. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. May act to directly link BRCA1, CREBBP or SMN1 and the RNA polymerase II complex. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active).

    Three dimensional structures from OCA and Proteopedia for DHX9 Gene

    Alternative splice isoforms for DHX9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX9 Gene

Proteomics data for DHX9 Gene at MOPED

Post-translational modifications for DHX9 Gene

  • May be phosphorylated by PRKDC/XRCC7. Phosphorylated by EIF2AK2/PKR and this phosphorylation perturbs its association with dsRNA.
  • Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys146, Lys191, Lys417, Lys857, Lys1037, and Lys1048

Other Protein References for DHX9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DHX9 Gene

Gene Families for DHX9 Gene

HGNC:
  • DHX :DEAH-boxes

UniProtKB/Swiss-Prot:

DHX9_HUMAN
Domain:
  • The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1.:
    • Q08211
  • Contains 2 DRBM (double-stranded RNA-binding) domains.:
    • Q08211
  • Contains 1 helicase ATP-binding domain.:
    • Q08211
  • Contains 1 helicase C-terminal domain.:
    • Q08211
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.:
    • Q08211
genes like me logo Genes that share domains with DHX9: view

Function for DHX9 Gene

Molecular function for DHX9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function: Unwinds double-stranded DNA and RNA in a 3 to 5 direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Positively regulates HIV-1 LTR-directed gene expression.

Enzyme Numbers (IUBMB) for DHX9 Gene

Gene Ontology (GO) - Molecular Function for DHX9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 17303075
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003724 RNA helicase activity TAS 8690889
GO:0004003 ATP-dependent DNA helicase activity TAS 9111062
genes like me logo Genes that share ontologies with DHX9: view
genes like me logo Genes that share phenotypes with DHX9: view

Animal Models for DHX9 Gene

MGI Knock Outs for DHX9:

No data available for Transcription Factor Targeting and HOMER Transcription for DHX9 Gene

Localization for DHX9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX9 Gene

Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX9 Gene COMPARTMENTS Subcellular localization image for DHX9 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DHX9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm TAS 8690889
GO:0005813 centrosome IDA 17498979
genes like me logo Genes that share ontologies with DHX9: view

Pathways for DHX9 Gene

genes like me logo Genes that share pathways with DHX9: view

Gene Ontology (GO) - Biological Process for DHX9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
GO:0007623 circadian rhythm IEA --
genes like me logo Genes that share ontologies with DHX9: view

Compounds for DHX9 Gene

(3) Novoseek inferred chemical compound relationships for DHX9 Gene

Compound -log(P) Hits PubMed IDs
actinomycin d 25.4 3
nacl 14.2 1
atp 10.1 4
genes like me logo Genes that share compounds with DHX9: view

Transcripts for DHX9 Gene

Unigene Clusters for DHX9 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX9 Gene

No ASD Table

Relevant External Links for DHX9 Gene

GeneLoc Exon Structure for
DHX9
ECgene alternative splicing isoforms for
DHX9

Expression for DHX9 Gene

mRNA expression in normal human tissues for DHX9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX9 Gene

SOURCE GeneReport for Unigene cluster for DHX9 Gene Hs.191518

genes like me logo Genes that share expressions with DHX9: view

Orthologs for DHX9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHX9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX9 36
  • 99.71 (n)
  • 100 (a)
DHX9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX9 36
  • 92.13 (n)
  • 95.62 (a)
DHX9 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX9 36
  • 91.99 (n)
  • 95.89 (a)
DHX9 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx9 36
  • 89.34 (n)
  • 93.58 (a)
Dhx9 16
Dhx9 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX9 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX9 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx9 36
  • 89.16 (n)
  • 93.58 (a)
lizard
(Anolis carolinensis)
Reptilia DHX9 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24763 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx9 36
  • 74.12 (n)
  • 82.72 (a)
Str.7575 36
zebrafish
(Danio rerio)
Actinopterygii dhx9 36
  • 70.28 (n)
  • 77.91 (a)
dhx9 37
  • 77 (a)
OneToOne
Dr.28193 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006599 36
  • 53.36 (n)
  • 52.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta mle 36
  • 54.71 (n)
  • 52.43 (a)
mle 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rha-1 36
  • 52.53 (n)
  • 45.4 (a)
rha-1 37
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.178 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToOne
Species with no ortholog for DHX9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX9 Gene

ENSEMBL:
Gene Tree for DHX9 (if available)
TreeFam:
Gene Tree for DHX9 (if available)

Paralogs for DHX9 Gene

Paralogs for DHX9 Gene

Selected SIMAP similar genes for DHX9 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DHX9 Gene

genes like me logo Genes that share paralogs with DHX9: view

Variants for DHX9 Gene

Sequence variations from dbSNP and Humsavar for DHX9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs860 -- 182,887,605(+) TGATT(G/T)TGTTT utr-variant-3-prime, nc-transcript-variant
rs861 -- 182,887,515(+) TATGT(A/T)TATTT utr-variant-3-prime, nc-transcript-variant
rs862 -- 182,887,687(+) GCCTT(A/T)AAATA utr-variant-3-prime, nc-transcript-variant
rs863 -- 182,887,662(+) TTTTT(C/T)CTTTA utr-variant-3-prime, nc-transcript-variant
rs864 -- 182,887,609(+) TTTGT(A/T)TATAT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX9 Gene

Variant ID Type Subtype PubMed ID
esv2537876 CNV Insertion 19546169

Relevant External Links for DHX9 Gene

HapMap Linkage Disequilibrium report
DHX9

Disorders for DHX9 Gene

(1) MalaCards Diseases for DHX9 Gene

Search for DHX9 Gene in MalaCards »

(4) University of Copenhagen DISEASES for DHX9 Gene

(4) Novoseek inferred disease relationships for DHX9 Gene

Disease -log(P) Hits PubMed IDs
werner syndrome 69.1 3
tumors 0 2
cancer 0 1
immunodeficiency 0 1

Relevant External Links for DHX9

Genetic Association Database (GAD)
DHX9
Human Genome Epidemiology (HuGE) Navigator
DHX9
genes like me logo Genes that share disorders with DHX9: view

No data available for UniProtKB/Swiss-Prot for DHX9 Gene

Publications for DHX9 Gene

  1. Domain structure of human nuclear DNA helicase II (RNA helicase A). (PMID: 9111062) Zhang S. … Grosse F. (J. Biol. Chem. 1997) 2 3 4 23
  2. A functional interaction between the survival motor neuron complex and RNA polymerase II. (PMID: 11149922) Pellizzoni L. … Dreyfuss G. (J. Cell Biol. 2001) 3 4 23
  3. Dual roles of RNA helicase A in CREB-dependent transcription. (PMID: 11416126) Aratani S. … Nakajima T. (Mol. Cell. Biol. 2001) 3 4 23
  4. Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles. (PMID: 8690889) Abdelhaleem M.M. … Greenberg A.H. (J. Immunol. 1996) 3 4 23
  5. Antithetic effects of MBD2a on gene regulation. (PMID: 12665568) Fujita H. … Nakajima T. (Mol. Cell. Biol. 2003) 3 4 23

Products for DHX9 Gene

Sources for DHX9 Gene

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