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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DHX8 Gene

protein-coding   GIFtS: 61
GCID: GC17P041572

DEAH (Asp-Glu-Ala-His) Box Polypeptide 8

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase))
(Previous symbol: DDX8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 81 2     PRP222
DDX81 2 3 5     PRPF222
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 8 (RNA Helicase)1 2     ATP-Dependent RNA Helicase DHX82
DEAH Box Protein 82 3     DEAH-Box Protein 82
RNA Helicase HRH12 3     EC 3.6.4.133
HRH12 5     EC 3.6.18

External Ids:    HGNC: 27491   Entrez Gene: 16592   Ensembl: ENSG000000675967   OMIM: 6003965   UniProtKB: Q145623   

Export aliases for DHX8 gene to outside databases

Previous GC identifers: GC17P042036 GC17P038916 GC17P037326


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DHX8 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast
Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DHX8 Gene: 
DHX8 (DEAH (Asp-Glu-Ala-His) box polypeptide 8) is a protein-coding gene. Diseases associated with DHX8 include atopic dermatitis, and variegate porphyria, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DHX33.

UniProtKB/Swiss-Prot: DHX8_HUMAN, Q14562
Function: Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome

summary for DHX8 Gene:
Histamine H1 receptors are Galphaq/11-protein-coupled receptors that mediate allergic responses. These
receptors are expressed in a wide variety of tissues including the gastrointestinal tract, central nervous
system, airway and vascular smooth muscle cells, endothelial cells, chondrocytes, monocytes, neutrophils,
dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems. H1
receptor activation induces a wide range of biological responses due to their widespread distribution. In
smooth muscle, H1 activation increases tension and the contractile response, and in vascular endothelial
cells receptor activation increases cell permeability. In the adrenal medulla, histamine acting at H1
receptors stimulates both adrenalin and noradrenalin release. Furthermore, H1 activation induces
prostacyclin and platelet-activating factor synthesis, promotes von Willebrand factor and nitric oxide
release, liberates arachidonic acid from phospholipids, and causes vasodilation of capillaries and
arterioles. At a physiological level, H1 receptors are involved in a wide array of processes including
thermal regulation, memory and learning, and control of the sleep-wake cycle, food intake, and emotional and
aggressive behaviors. Histamine acting through the H1 receptor has proinflammatory effects, and is involved
in the development of various aspects of the antigen-specific immune response. Activation of these receptors
triggers maturation of dendritic cells and modulates the balance of Th1 and Th2 cells. H1 receptors are
involved in the pathological process of allergy, including allergic rhinits, atopic dermatitis, anaphylaxis
and asthma, and also have a role in autoimmune diseases and malignancy.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DHX8 gene promoter:
         STAT1   AML1a   LCR-F1   Tal-1beta   STAT1alpha   E47   AREB6   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX8 promoter sequence
   Search SABiosciences Chromatin IP Primers for DHX8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DHX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

DHX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041572:  view genomic region     (about GC identifiers)

Start:
41,561,233 bp from pter      End:
41,621,831 bp from pter
Size:
60,599 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHX8_HUMAN, Q14562 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DHX8  
Size: 1220 amino acids; 139315 Da
Subunit: Identified in the spliceosome C complex. Interacts with ARRB2; the interaction is detected in the nucleus
upon OR1D2 stimulation
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for DHX8:
2EQS (3D)        3I4U (3D)    

Explore the universe of human proteins at neXtProt for DHX8: NX_Q14562

Explore proteomics data for DHX8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14562

  • 4/20 DME Specific Peptides for DHX8 (Q14562) (see all 20)
     TNIAETS  TVMQIHL  YVVDPGF  FLTGQEE 

    DHX8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DHX8 Protein Expression
    REFSEQ proteins: NP_004932.1  
    ENSEMBL proteins: 
     ENSP00000467834   ENSP00000437886   ENSP00000262415   ENSP00000474654   ENSP00000466900  
     ENSP00000465178  

    Human Recombinant Protein Products for DHX8: 
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    Novus Biologicals DHX8 Protein
    Novus Biologicals DHX8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex TAS7935475
    GO:0005730NOT nucleolus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    DHX8 for ontologies           About GeneDecksing



    DHX8 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DHX8 

    Assay Products for DHX8: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DHX8 
    Cloud-Clone Corp. CLIAs for DHX8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DHX: DEAH-boxes

    5/10 InterPro protein domains (see all 10):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR012340 NA-bd_OB-fold

    Graphical View of Domain Structure for InterPro Entry Q14562

    ProtoNet protein and cluster: Q14562

    4 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB003029 RNA binding S1
    IPB007502 Helicase-associated region
    IPB013957 Protein of unknown function DUF1777


    UniProtKB/Swiss-Prot: DHX8_HUMAN, Q14562
    Domain: The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the
    spliceosome
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 S1 motif domain


    DHX8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX8_HUMAN, Q14562
    Function: Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004004ATP-dependent RNA helicase activity TAS7935475
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI16820410
         
    DHX8 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for DHX8:
     Cell division defect  Decreased cell number, increas  Decreased influenza A virus in  Decreased number of cells in m 
     Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DHX8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DHX8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX8 

    miRNA
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    miRTarBase miRNAs that target DHX8:
    hsa-mir-192 (MIRT004851)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DHX8:
    hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidDHX8 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DHX8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DHX8
        mRNA processing


    1         Kegg Pathway  (Kegg details for DHX8):
        Spliceosome


    DHX8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHX8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/671 Interacting proteins for DHX8 (Q145622, 3 ENSP000002624154) via UniProtKB, MINT, STRING, and/or I2D (see all 671)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-7945693 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000225073Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000229496Q138382, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006396RNA processing TAS7935475
    GO:0006810transport ----
    GO:0008380RNA splicing TAS7935475

    DHX8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DHX8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for DHX8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Clemastine fumarateH1 antagonist[14976-57-9]
    Histamine dihydrochlorideEndogenous histamine receptor agonist[56-92-8]
    2-Pyridylethylamine dihydrochlorideH1 receptor agonist[3343-39-3]
    Astemizole Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker. [68844-77-9]
    Mepyramine maleateSelective H1 inverse agonist[59-33-6]

    2 Novoseek inferred chemical compound relationships for DHX8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 32.4 3 7935475 (1), 8608946 (1)
    atp 22.4 4 9582286 (3), 16008364 (1)

    Search CenterWatch for drugs/clinical trials and news about DHX8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DHX8 gene: 
    NM_004941.1  

    Unigene Cluster for DHX8:

    DEAH (Asp-Glu-Ala-His) box polypeptide 8
    Hs.463105  [show with all ESTs]
    Unigene Representative Sequence: BC038223
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592258 ENST00000540306(uc010wif.1 uc010wig.2) ENST00000262415(uc002idu.1)
    ENST00000605777 ENST00000587044 ENST00000589898 ENST00000587574
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DHX8
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DHX8:
    hsa-miR-605
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    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AK291664.1 AK294046.1 AK303319.1 BC020697.1 BC038223.1 BC044586.1 BC047327.1 D50487.1 

    13 DOTS entries:

    DT.115915  DT.100673816  DT.405741  DT.100698941  DT.447246  DT.95153044  DT.95372835  DT.91768818 
    DT.120927687  DT.120927861  DT.91768815  DT.97764921  DT.40124304 

    24/252 AceView cDNA sequences (see all 252):

    AI989729 AI346393 BP348422 CA426013 BE890949 BP380370 AL046073 BQ017088 
    BQ220960 AW002011 AA376774 BM828334 AI142440 BM969924 AI632523 BP370060 
    AI333677 CB143365 AU132406 AI921600 AA887968 AI424756 BC020697 AU140301 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DHX8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
    SP1:                                            -                                                                                                     -         
    SP2:              -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                              
    SP2:                              
    SP3:                    -         
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for DHX8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DHX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGTGCCC
    DHX8 Expression
    About this image


    See DHX8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DHX8

    SOURCE GeneReport for Unigene cluster: Hs.463105
        SABiosciences Custom PCR Arrays for DHX8
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DHX8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX8 gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx81 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 81, 5 89.45(n)1
    98.52(a)1
      11 (65.48 cM)5
    2172071  NM_144831.21  NP_659080.21 
     1017329195 
    chicken
    (Gallus gallus)
    Aves DHX81 DEAH (Asp-Glu-Ala-His) box polypeptide 8 81.46(n)
    95.44(a)
      419982  XM_418105.3  XP_418105.3 
    lizard
    (Anolis carolinensis)
    Reptilia DHX86
    DEAH (Asp-Glu-Ala-His) box polypeptide 8
    95(a)
    1 ↔ 1
    6(61718875-61751525)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985561.12   -- 80.24(n)    CA985561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dhx81 DEAH (Asp-Glu-Ala-His) box polypeptide 8 78.08(n)
    92.13(a)
      606595  XM_002663949.1  XP_002663995.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pea1 peanuts 65.27(n)
    72.35(a)
      36561  NM_137084.2  NP_610928.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mog-51 Protein MOG-5 59.67(n)
    64.78(a)
      173920  NM_062618.5  NP_495019.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DHR2(YKL078W)4
    PRP221
    Predominantly nucleolar DEAH-box ATP-dependent RNA more4
    Prp22p1
    55.3(n)1
    53.25(a)1
      11(288845-291052)4
    8567321  NP_010929.31  8537844 
     NP_012845.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G265601 ATP-dependent RNA helicase DHX8/PRP22 60.55(n)
    63.13(a)
      822264  NM_113564.3  NP_189288.1 
    rice
    (Oryza sativa)
    Liliopsida Os.66392 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.73(n)    AK100422.1 


    ENSEMBL Gene Tree for DHX8 (if available)
    TreeFam Gene Tree for DHX8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DHX8 gene
    DHX332  DHX402  DHX352  DHX162  DHX152  DHX382  DHX342  
    9 SIMAP similar genes for DHX8 using alignment to 8 protein entries:     DHX8_HUMAN (see all proteins):
    DHX16    DHX15    DHX33    DHX38    DHX40    DKFZp762F2011
    DHX35    DHX32    DQX1

    DHX8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/924 SNPs in DHX8 are shown (see all 924)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38097511,2
    C,F,A,H--41559785(-) CACACT/CCCAGT 1 -- int119Minor allele frequency- C:0.30EA NS NA WA 3834
    rs739875071,2
    C,F--41559854(+) AGTTGG/AGAGAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs352584431,2
    C--41559915(+) TTGTT-/GTTTTTGT 2 -- int1 cds11Minor allele frequency- GTT:0.00NA 2
    rs1840823661,2
    --41560119(+) CAGACA/GAGGTT 1 -- int10--------
    rs1877202651,2
    --41560120(+) AGACGA/CGGTTT 1 -- int10--------
    rs1441691581,2
    --41560128(+) TTTCAC/TCATGT 1 -- int10--------
    rs1486991041,2
    --41560129(+) TTCACC/TATGTT 1 -- int10--------
    rs1413228881,2
    --41560177(+) CGCCCA/GTCTCG 1 -- int10--------
    rs1507306361,2
    --41560230(+) CAGCCC/GCTGGG 1 -- int10--------
    rs668022761,2
    C--41560363(+) AGTTC-/CTATGTGA 1 -- cds10--------

    HapMap Linkage Disequilibrium report for DHX8 (41561233 - 41621831 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DHX8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833451CNV Loss17160897
    nsv470588CNV Gain18288195
    nsv833453CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600396    OMIM disorders: --

    6 diseases for DHX8:    About MalaCards
    atopic dermatitis    variegate porphyria    dermatitis    porphyria
    asthma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for DHX8:
    Variegate porphyria

    DHX8 for disorders           About GeneDecksing


    Export disorders for DHX8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DHX8 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with DHX8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22. (PubMed id 7935475)1, 2, 3, 9 Ono Y.... Shimura Y. (1994)
    2. A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. (PubMed id 8608946)1, 2, 9 Ohno M. and Shimura Y. (1996)
    3. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (2006)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Arabidopsis root initiation defective1, a DEAH-box RNA helicase involved in pre-mRNA splicing, is essential for plant development. (PubMed id 23771891)1 Ohtani M....Sugiyama M. (2013)
    6. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    7. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    8. Structural analysis of the C-terminal domain of the sp liceosomal helicase Prp22. (PubMed id 23096351)1 Kudlinzki D....Ficner R. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1659 HGNC: 2749 AceView: DHX8 Ensembl:ENSG00000067596 euGenes: HUgn1659
    ECgene: DHX8 Kegg: 1659 H-InvDB: DHX8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DHX8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DHX8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DHX8 gene:
    Search GeneIP for patents involving DHX8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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