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DHX8 Gene

protein-coding   GIFtS: 60
GCID: GC17P041569

DEAH (Asp-Glu-Ala-His) Box Polypeptide 8

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase))
(Previous symbol: DDX8)
  See DHX8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAH (Asp-Glu-Ala-His) Box Polypeptide 81 2     PRP222
DDX81 2 3 5     PRPF222
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 8 (RNA Helicase)1 2     ATP-Dependent RNA Helicase DHX82
DEAH Box Protein 82 3     DEAH-Box Protein 82
RNA Helicase HRH12 3     EC 3.6.4.133
HRH12 5     EC 3.6.18

External Ids:    HGNC: 27491   Entrez Gene: 16592   Ensembl: ENSG000000675967   OMIM: 6003965   UniProtKB: Q145623   

Export aliases for DHX8 gene to outside databases

Previous GC identifers: GC17P041572 GC17P042036 GC17P038916 GC17P037326


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DHX8 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast
Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DHX8 Gene:
DHX8 (DEAH (Asp-Glu-Ala-His) box polypeptide 8) is a protein-coding gene. Diseases associated with DHX8 include atopic dermatitis, and dermatitis. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DHX33.

UniProtKB/Swiss-Prot: DHX8_HUMAN, Q14562
Function: Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome

summary for DHX8 Gene:
Histamine H1 receptors are Galphaq/11-protein-coupled receptors that mediate allergic responses. These
receptors are expressed in a wide variety of tissues including the gastrointestinal tract, central nervous
system, airway and vascular smooth muscle cells, endothelial cells, chondrocytes, monocytes, neutrophils,
dendritic cells, T and B lymphocytes, adrenal medulla, and the cardiovascular and genitourinary systems. H1
receptor activation induces a wide range of biological responses due to their widespread distribution. In
smooth muscle, H1 activation increases tension and the contractile response, and in vascular endothelial
cells receptor activation increases cell permeability. In the adrenal medulla, histamine acting at H1
receptors stimulates both adrenalin and noradrenalin release. Furthermore, H1 activation induces
prostacyclin and platelet-activating factor synthesis, promotes von Willebrand factor and nitric oxide
release, liberates arachidonic acid from phospholipids, and causes vasodilation of capillaries and
arterioles. At a physiological level, H1 receptors are involved in a wide array of processes including
thermal regulation, memory and learning, and control of the sleep-wake cycle, food intake, and emotional and
aggressive behaviors. Histamine acting through the H1 receptor has proinflammatory effects, and is involved
in the development of various aspects of the antigen-specific immune response. Activation of these receptors
triggers maturation of dendritic cells and modulates the balance of Th1 and Th2 cells. H1 receptors are
involved in the pathological process of allergy, including allergic rhinits, atopic dermatitis, anaphylaxis
and asthma, and also have a role in autoimmune diseases and malignancy.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DHX8 gene promoter:
         STAT1   AML1a   LCR-F1   Tal-1beta   STAT1alpha   E47   AREB6   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDHX8 promoter sequence
   Search Chromatin IP Primers for DHX8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DHX8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

DHX8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHX8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041569:  view genomic region     (about GC identifiers)

Start:
41,561,233 bp from pter      End:
41,621,831 bp from pter
Size:
60,599 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DHX8_HUMAN, Q14562 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DHX8  
Size: 1220 amino acids; 139315 Da
Subunit: Identified in the spliceosome C complex. Interacts with ARRB2; the interaction is detected in the nucleus
upon OR1D2 stimulation
2 PDB 3D structures from and Proteopedia for DHX8:
2EQS (3D)        3I4U (3D)    

Explore the universe of human proteins at neXtProt for DHX8: NX_Q14562

Explore proteomics data for DHX8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DHX8 (Q14562) (see all 20)
     TNIAETS  TVMQIHL  YVVDPGF  FLTGQEE 


    See DHX8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004932.1  
    ENSEMBL proteins: 
     ENSP00000467834   ENSP00000437886   ENSP00000262415   ENSP00000474654   ENSP00000466900  
     ENSP00000465178  

    DHX8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals DHX8 Protein
    Novus Biologicals DHX8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DHX8

     
    Search eBioscience for Proteins for DHX8 

    DHX8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for DHX8
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    Search ThermoFisher Antibodies for DHX8
    LSBio Antibodies in human, mouse, rat for DHX8

    DHX8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DHX8
    Cloud-Clone Corp. CLIAs for DHX8
    Search eBioscience for ELISAs for DHX8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DHX: DEAH-boxes

    Selected InterPro protein domains (see all 10):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR007502 Helicase-assoc_dom
     IPR012340 NA-bd_OB-fold

    Graphical View of Domain Structure for InterPro Entry Q14562

    ProtoNet protein and cluster: Q14562

    4 Blocks protein domains:
    IPB002464 ATP-dependent helicase
    IPB003029 RNA binding S1
    IPB007502 Helicase-associated region
    IPB013957 Protein of unknown function DUF1777


    UniProtKB/Swiss-Prot: DHX8_HUMAN, Q14562
    Domain: The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the
    spliceosome
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 S1 motif domain


    Find genes that share domains with DHX8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHX8_HUMAN, Q14562
    Function: Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004004ATP-dependent RNA helicase activity TAS7935475
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI16820410
         
    Find genes that share ontologies with DHX8           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for DHX8:
     Cell division defect  Decreased cell number, increas  Decreased influenza A virus in  Decreased number of cells in m 
     Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DHX8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DHX8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DHX8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DHX8

    miRNA
    Products:
        
    miRTarBase miRNAs that target DHX8:
    hsa-mir-92a-3p (MIRT049306), hsa-mir-30c-5p (MIRT047917), hsa-mir-935 (MIRT036658), hsa-mir-16-5p (MIRT031619), hsa-mir-1180-3p (MIRT035945), hsa-mir-331-3p (MIRT043497), hsa-mir-30a-5p (MIRT028503)

    Block miRNA regulation of human, mouse, rat DHX8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DHX8:
    hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidDHX8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DHX8
    Predesigned siRNA for gene silencing in human, mouse, rat DHX8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DHX8

    Clone
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    OriGene clones in human, mouse for DHX8 (see all 7)
    OriGene ORF clones in mouse, rat for DHX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX8 (NM_004941)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX8

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DHX8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHX8_HUMAN, Q14562: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex TAS7935475
    GO:0005730NOT nucleolus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with DHX8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DHX8 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Spliceosome
    Spliceosome


    Find genes that share SuperPaths with DHX8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DHX8
        mRNA processing


    1 Kegg Pathway  (Kegg details for DHX8):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DHX8
    Interactions:

        Search GeneGlobe Interaction Network for DHX8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DHX8 (Q145621, 2, 3 ENSP000002624154) via UniProtKB, MINT, STRING, and/or I2D (see all 798)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000215425Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000229496Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000230624Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000235439Q138382, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006200ATP catabolic process TAS7935475
    GO:0006396RNA processing TAS7935475
    GO:0006810transport ----
    GO:0008380RNA splicing TAS7935475

    Find genes that share ontologies with DHX8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for DHX8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Clemastine fumarateH1 antagonist[14976-57-9]
    Histamine dihydrochlorideEndogenous histamine receptor agonist[56-92-8]
    2-Pyridylethylamine dihydrochlorideH1 receptor agonist[3343-39-3]
    Astemizole Orally active, potent H1 antagonist. Also KV11.1 (hERG) channel blocker. [68844-77-9]
    Mepyramine maleateSelective H1 inverse agonist[59-33-6]

    2 Novoseek inferred chemical compound relationships for DHX8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 32.4 3 7935475 (1), 8608946 (1)
    atp 22.4 4 9582286 (3), 16008364 (1)



    Find genes that share compounds with DHX8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DHX8 gene: 
    NM_004941.1  

    Unigene Cluster for DHX8:

    DEAH (Asp-Glu-Ala-His) box polypeptide 8
    Hs.463105  [show with all ESTs]
    Unigene Representative Sequence: BC038223
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592258 ENST00000540306(uc010wif.1 uc010wig.2) ENST00000262415(uc002idu.1)
    ENST00000605777 ENST00000587044 ENST00000589898 ENST00000587574
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DHX8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DHX8:
    hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidDHX8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DHX8
    Predesigned siRNA for gene silencing in human, mouse, rat DHX8
    Clone
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    OriGene ORF clones in mouse, rat for DHX8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DHX8 (NM_004941)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DHX8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DHX8
    Primer
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    OriGene qPCR primer pairs and template standards for DHX8
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX8
      QuantiTect SYBR Green Assays in human, mouse, rat DHX8
      QuantiFast Probe-based Assays in human, mouse, rat DHX8

    Additional mRNA sequence: 

    AK291664.1 AK294046.1 AK303319.1 BC020697.1 BC038223.1 BC044586.1 BC047327.1 D50487.1 

    13 DOTS entries:

    DT.115915  DT.100673816  DT.405741  DT.100698941  DT.447246  DT.95153044  DT.95372835  DT.91768818 
    DT.120927687  DT.120927861  DT.91768815  DT.97764921  DT.40124304 

    Selected AceView cDNA sequences (see all 252):

    AI884783 AI921600 BU527292 AI346393 BM969924 BE745580 BM997447 BM828334 
    AL712228 BP380370 BF593632 AW296480 CR600304 BP348422 AA376774 AW002011 
    AA843939 CF552649 BC044586 W86627 AW002010 CA426013 AI632523 AI142440 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DHX8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
    SP1:                                            -                                                                                                     -         
    SP2:              -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                              
    SP2:                              
    SP3:                    -         
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for DHX8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DHX8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGTGCCC
    DHX8 Expression
    About this image

    DHX8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DHX8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463105
        Custom PCR Arrays for DHX8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DHX8
    OriGene qSTAR qPCR primer pairs in human, mouse for DHX8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DHX8
    QuantiTect SYBR Green Assays in human, mouse, rat DHX8
    QuantiFast Probe-based Assays in human, mouse, rat DHX8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DHX8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DHX8 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dhx81 , 5 DEAH (Asp-Glu-Ala-His) box polypeptide 81, 5 89.12(n)1
    98.02(a)1
      11 (65.48 cM)5
    2172071  NM_144831.21  NP_659080.21 
     1017329195 
    chicken
    (Gallus gallus)
    Aves DHX81 DEAH (Asp-Glu-Ala-His) box polypeptide 8 80.59(n)
    94.18(a)
      419982  XM_418105.4  XP_418105.3 
    lizard
    (Anolis carolinensis)
    Reptilia DHX86
    DEAH (Asp-Glu-Ala-His) box polypeptide 8
    95(a)
    1 ↔ 1
    6(61718875-61751525)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985561.12   -- 80.24(n)    CA985561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dhx81 DEAH (Asp-Glu-Ala-His) box polypeptide 8 78.21(n)
    92.47(a)
      606595  XM_002663947.2  XP_002663993.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pea6
    peanuts
    70(a)
    1 ↔ 1
    2R(10040661-10044611)
    worm
    (Caenorhabditis elegans)
    Secernentea mog-51 mog-5 62.35(n)
    69.2(a)
      173920  NM_062618.6  NP_495019.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DHR2(YKL078W)4
    PRP221
    Predominantly nucleolar DEAH-box ATP-dependent RNA more4
    PRP221
    55.17(n)1
    53.08(a)1
      11(288845-291052)4
    8567321  NP_010929.31  8537844 
     NP_012845.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G265601 AT3G26560 59.47(n)
    61.09(a)
      822264  NM_113564.3  NP_189288.1 
    rice
    (Oryza sativa)
    Liliopsida Os.66392 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.73(n)    AK100422.1 


    ENSEMBL Gene Tree for DHX8 (if available)
    TreeFam Gene Tree for DHX8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DHX8 gene
    DHX332  DHX162  DHX352  DHX152  DQX12  DHX322  
    9 SIMAP similar genes for DHX8 using alignment to 9 protein entries:     DHX8_HUMAN (see all proteins):
    DHX15    DHX16    DHX33    DHX38    DHX40    DKFZp762F2011
    DHX35    DHX32    DQX1

    Find genes that share paralogs with DHX8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DHX8 (see all 924)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38097511,2
    C,F,A,H--41559785(-) CACACT/CCCAGT 1 -- int119Minor allele frequency- C:0.30EA NS NA WA 3834
    rs739875071,2
    C,F--41559854(+) AGTTGG/AGAGAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs352584431,2
    C--41559915(+) TTGTT-/GTTTTTGT 2 -- int1 cds11Minor allele frequency- GTT:0.00NA 2
    rs1840823661,2
    --41560119(+) CAGACA/GAGGTT 1 -- int10--------
    rs1877202651,2
    --41560120(+) AGACGA/CGGTTT 1 -- int10--------
    rs1441691581,2
    --41560128(+) TTTCAC/TCATGT 1 -- int10--------
    rs1486991041,2
    --41560129(+) TTCACC/TATGTT 1 -- int10--------
    rs1413228881,2
    --41560177(+) CGCCCA/GTCTCG 1 -- int10--------
    rs1507306361,2
    --41560230(+) CAGCCC/GCTGGG 1 -- int10--------
    rs668022761,2
    C--41560363(+) AGTTC-/CTATGTGA 1 -- cds10--------

    HapMap Linkage Disequilibrium report for DHX8 (41561233 - 41621831 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DHX8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833451CNV Loss17160897
    nsv470588CNV Gain18288195
    nsv833453CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DHX8
    DNA2.0 Custom Variant and Variant Library Synthesis for DHX8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600396    OMIM disorders: --

    4 diseases for DHX8:    
    About MalaCards
    atopic dermatitis    dermatitis    variegate porphyria    asthma

    1 disease from the University of Copenhagen DISEASES database for DHX8:
    Variegate porphyria

    Find genes that share disorders with DHX8           About GenesLikeMe


    Export disorders for DHX8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DHX8 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with DHX8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22. (PubMed id 7935475)1, 2, 3, 9 Ono Y.... Shimura Y. (Mol. Cell. Biol. 1994)
    2. A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. (PubMed id 8608946)1, 2, 9 Ohno M. and Shimura Y. (Genes Dev. 1996)
    3. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (J. Cell Sci. 2006)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Arabidopsis root initiation defective1, a DEAH-box RNA helicase involved in pre-mRNA splicing, is essential for plant development. (PubMed id 23771891)1 Ohtani M....Sugiyama M. (Plant Cell 2013)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    8. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    9. Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22. (PubMed id 23096351)1 Kudlinzki D....Ficner R. (Biol. Chem. 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1659 HGNC: 2749 AceView: DHX8 Ensembl:ENSG00000067596 euGenes: HUgn1659
    ECgene: DHX8 Kegg: 1659 H-InvDB: DHX8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DHX8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DHX8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DHX8 gene:
    Search GeneIP for patents involving DHX8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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