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Aliases for DHX8 Gene

Aliases for DHX8 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 8 2 3
  • DDX8 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 8 (RNA Helicase) 2 3
  • DEAH Box Protein 8 3 4
  • RNA Helicase HRH1 3 4
  • HRH1 3 6
  • ATP-Dependent RNA Helicase DHX8 3
  • EC 4
  • EC 3.6.1 63
  • PRPF22 3
  • PRP22 3

External Ids for DHX8 Gene

Previous HGNC Symbols for DHX8 Gene

  • DDX8

Previous GeneCards Identifiers for DHX8 Gene

  • GC17P041572
  • GC17P042036
  • GC17P038916
  • GC17P037326
  • GC17P041569

Summaries for DHX8 Gene

Entrez Gene Summary for DHX8 Gene

  • This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for DHX8 Gene

DHX8 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 8) is a Protein Coding gene. Diseases associated with DHX8 include atopic dermatitis and dermatitis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DHX35.

UniProtKB/Swiss-Prot for DHX8 Gene

  • Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX8 Gene

Genomics for DHX8 Gene

Regulatory Elements for DHX8 Gene

Genomic Location for DHX8 Gene

43,483,865 bp from pter
43,544,463 bp from pter
60,599 bases
Plus strand

Genomic View for DHX8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX8 Gene

Proteins for DHX8 Gene

  • Protein details for DHX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DHX8
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DHX8 Gene

    1220 amino acids
    Molecular mass:
    139315 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.

    Three dimensional structures from OCA and Proteopedia for DHX8 Gene

neXtProt entry for DHX8 Gene

Proteomics data for DHX8 Gene at MOPED

Post-translational modifications for DHX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX8 Gene

Antibody Products

Domains for DHX8 Gene

Gene Families for DHX8 Gene

  • DHX :DEAH-boxes

Graphical View of Domain Structure for InterPro Entry



  • Q14562
  • The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 S1 motif domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
genes like me logo Genes that share domains with DHX8: view

Function for DHX8 Gene

Molecular function for DHX8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

Enzyme Numbers (IUBMB) for DHX8 Gene

Gene Ontology (GO) - Molecular Function for DHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0004004 ATP-dependent RNA helicase activity TAS 7935475
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 16820410
genes like me logo Genes that share ontologies with DHX8: view
genes like me logo Genes that share phenotypes with DHX8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX8 Gene

Localization for DHX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX8 Gene

Subcellular locations from

Jensen Localization Image for DHX8 Gene COMPARTMENTS Subcellular localization image for DHX8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7935475
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex TAS 7935475
GO:0005737 cytoplasm IBA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DHX8: view

Pathways for DHX8 Gene

genes like me logo Genes that share pathways with DHX8: view

Gene Ontology (GO) - Biological Process for DHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing TAS 7935475
GO:0006810 transport --
GO:0008380 RNA splicing TAS 7935475
genes like me logo Genes that share ontologies with DHX8: view

Compounds for DHX8 Gene

(2) Novoseek inferred chemical compound relationships for DHX8 Gene

Compound -log(P) Hits PubMed IDs
arginine 32.4 2
atp 22.4 4
genes like me logo Genes that share compounds with DHX8: view

Transcripts for DHX8 Gene

Unigene Clusters for DHX8 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: -

ExUns: 20b ^ 21 ^ 22 ^ 23 ^ 24
SP3: -

Relevant External Links for DHX8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHX8 Gene

mRNA expression in normal human tissues for DHX8 Gene

Protein differential expression in normal tissues for DHX8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.6) and CD8 Tcells (15.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX8 Gene

SOURCE GeneReport for Unigene cluster for DHX8 Gene Hs.463105

genes like me logo Genes that share expressions with DHX8: view

Expression partners for DHX8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX8 Gene

Orthologs for DHX8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHX8 35
  • 91.96 (n)
  • 98.51 (a)
DHX8 36
  • 98 (a)
(Canis familiaris)
Mammalia DHX8 35
  • 91.51 (n)
  • 99 (a)
DHX8 36
  • 99 (a)
(Mus musculus)
Mammalia Dhx8 35
  • 89.12 (n)
  • 98.02 (a)
Dhx8 16
Dhx8 36
  • 97 (a)
(Pan troglodytes)
Mammalia DHX8 35
  • 99.89 (n)
  • 100 (a)
DHX8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dhx8 35
  • 91.07 (n)
  • 97.32 (a)
(Monodelphis domestica)
Mammalia DHX8 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
(Gallus gallus)
Aves DHX8 35
  • 80.59 (n)
  • 94.18 (a)
DHX8 36
  • 95 (a)
(Anolis carolinensis)
Reptilia DHX8 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC733563 35
  • 76.79 (n)
  • 91.83 (a)
Str.6061 35
(Danio rerio)
Actinopterygii dhx8 35
  • 78.21 (n)
  • 92.47 (a)
dhx8 36
  • 91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4139 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007212 35
  • 65.87 (n)
  • 73.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta pea 36
  • 70 (a)
(Caenorhabditis elegans)
Secernentea mog-5 35
  • 62.35 (n)
  • 69.2 (a)
mog-5 36
  • 63 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR020W 35
  • 56.41 (n)
  • 54.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11638g 35
  • 55.65 (n)
  • 53.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP22 35
  • 55.17 (n)
  • 53.08 (a)
DHR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26560 35
  • 59.47 (n)
  • 61.09 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8910 35
(Hordeum vulgare)
Liliopsida Hv.5274 35
(Oryza sativa)
Liliopsida Os.6639 35
Os06g0343100 35
  • 60.6 (n)
  • 61.54 (a)
(Triticum aestivum)
Liliopsida Ta.26697 35
(Zea mays)
Liliopsida Zm.3754 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06318 35
  • 58.84 (n)
  • 60.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp22 35
  • 56.84 (n)
  • 56.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
Species with no ortholog for DHX8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHX8 Gene

Gene Tree for DHX8 (if available)
Gene Tree for DHX8 (if available)

Paralogs for DHX8 Gene

Paralogs for DHX8 Gene

genes like me logo Genes that share paralogs with DHX8: view

Variants for DHX8 Gene

Sequence variations from dbSNP and Humsavar for DHX8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1971 -- 43,525,150(+) GTTTC(A/G)GAACT utr-variant-3-prime, intron-variant
rs14513 -- 43,524,201(+) TGATG(C/T)CCCAG utr-variant-3-prime, intron-variant
rs1319065 -- 43,523,213(+) CAGTA(A/G)AAGGG intron-variant
rs1319066 -- 43,523,167(+) ATCTA(A/G)AACCC intron-variant
rs1382685 -- 43,485,783(-) TACTT(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX8 Gene

Variant ID Type Subtype PubMed ID
nsv833451 CNV Loss 17160897
nsv470588 CNV Gain 18288195
nsv833453 CNV Gain+Loss 17160897

Relevant External Links for DHX8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX8 Gene

Disorders for DHX8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DHX8 Gene in MalaCards »

(3) Diseases for DHX8 Gene including...

(1) University of Copenhagen DISEASES for DHX8 Gene

genes like me logo Genes that share disorders with DHX8: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for DHX8 Gene

Publications for DHX8 Gene

  1. Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22. (PMID: 7935475) Ono Y. … Shimura Y. (Mol. Cell. Biol. 1994) 2 3 4 23
  2. A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. (PMID: 8608946) Ohno M. … Shimura Y. (Genes Dev. 1996) 3 4 23
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PMID: 16820410) Neuhaus E.M. … Hatt H. (J. Cell Sci. 2006) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for DHX8 Gene

Sources for DHX8 Gene

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