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Aliases for DHX8 Gene

Aliases for DHX8 Gene

  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 8 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 8 (RNA Helicase) 2 3
  • DEAH Box Protein 8 3 4
  • RNA Helicase HRH1 3 4
  • DDX8 3 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • PRPF22 3
  • PRP22 3
  • HRH1 3

External Ids for DHX8 Gene

Previous HGNC Symbols for DHX8 Gene

  • DDX8

Previous GeneCards Identifiers for DHX8 Gene

  • GC17P041572
  • GC17P042036
  • GC17P038916
  • GC17P037326
  • GC17P041569

Summaries for DHX8 Gene

Entrez Gene Summary for DHX8 Gene

  • This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for DHX8 Gene

DHX8 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is DHX35.

UniProtKB/Swiss-Prot for DHX8 Gene

  • Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX8 Gene

Genomics for DHX8 Gene

Regulatory Elements for DHX8 Gene

Genomic Location for DHX8 Gene

Chromosome:
17
Start:
43,483,865 bp from pter
End:
43,544,463 bp from pter
Size:
60,599 bases
Orientation:
Plus strand

Genomic View for DHX8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX8 Gene

Proteins for DHX8 Gene

  • Protein details for DHX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14562-DHX8_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DHX8
    Protein Accession:
    Q14562

    Protein attributes for DHX8 Gene

    Size:
    1220 amino acids
    Molecular mass:
    139315 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.

    Three dimensional structures from OCA and Proteopedia for DHX8 Gene

neXtProt entry for DHX8 Gene

Proteomics data for DHX8 Gene at MOPED

Post-translational modifications for DHX8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX8 Gene

Antibody Products

Domains & Families for DHX8 Gene

Gene Families for DHX8 Gene

Graphical View of Domain Structure for InterPro Entry

Q14562

UniProtKB/Swiss-Prot:

DHX8_HUMAN :
  • The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
Domain:
  • The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 S1 motif domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
genes like me logo Genes that share domains with DHX8: view

Function for DHX8 Gene

Molecular function for DHX8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.

Enzyme Numbers (IUBMB) for DHX8 Gene

Gene Ontology (GO) - Molecular Function for DHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity TAS 7935475
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 16820410
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DHX8: view
genes like me logo Genes that share phenotypes with DHX8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DHX8 Gene

Localization for DHX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX8 Gene COMPARTMENTS Subcellular localization image for DHX8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7935475
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex TAS 7935475
GO:0005737 cytoplasm IBA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DHX8: view

Pathways & Interactions for DHX8 Gene

genes like me logo Genes that share pathways with DHX8: view

Gene Ontology (GO) - Biological Process for DHX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006396 RNA processing TAS 7935475
GO:0008152 metabolic process --
GO:0008380 RNA splicing TAS 7935475
genes like me logo Genes that share ontologies with DHX8: view

No data available for SIGNOR curated interactions for DHX8 Gene

Drugs & Compounds for DHX8 Gene

(3) Drugs for DHX8 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
ATP Pharma Activator 0
arginine Nutra 346

(3) Additional Compounds for DHX8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DHX8: view

Transcripts for DHX8 Gene

Unigene Clusters for DHX8 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DHX8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5:

ExUns: 20b ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for DHX8 Gene

GeneLoc Exon Structure for
DHX8
ECgene alternative splicing isoforms for
DHX8

Expression for DHX8 Gene

mRNA expression in normal human tissues for DHX8 Gene

Protein differential expression in normal tissues from HIPED for DHX8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.6) and CD8 Tcells (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DHX8 Gene



SOURCE GeneReport for Unigene cluster for DHX8 Gene Hs.463105

genes like me logo Genes that share expression patterns with DHX8: view

Protein tissue co-expression partners for DHX8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DHX8 Gene

Orthologs for DHX8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DHX8 35
  • 91.96 (n)
  • 98.51 (a)
DHX8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX8 35
  • 91.51 (n)
  • 99 (a)
DHX8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx8 35
  • 89.12 (n)
  • 98.02 (a)
Dhx8 16
Dhx8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX8 35
  • 99.89 (n)
  • 100 (a)
DHX8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx8 35
  • 91.07 (n)
  • 97.32 (a)
oppossum
(Monodelphis domestica)
Mammalia DHX8 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves DHX8 35
  • 80.59 (n)
  • 94.18 (a)
DHX8 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX8 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC733563 35
  • 76.79 (n)
  • 91.83 (a)
Str.6061 35
zebrafish
(Danio rerio)
Actinopterygii dhx8 35
  • 78.21 (n)
  • 92.47 (a)
dhx8 36
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4139 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007212 35
  • 65.87 (n)
  • 73.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta pea 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mog-5 35
  • 62.35 (n)
  • 69.2 (a)
mog-5 36
  • 63 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR020W 35
  • 56.41 (n)
  • 54.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11638g 35
  • 55.65 (n)
  • 53.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP22 35
  • 55.17 (n)
  • 53.08 (a)
DHR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26560 35
  • 59.47 (n)
  • 61.09 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8910 35
barley
(Hordeum vulgare)
Liliopsida Hv.5274 35
rice
(Oryza sativa)
Liliopsida Os.6639 35
Os06g0343100 35
  • 60.6 (n)
  • 61.54 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.26697 35
corn
(Zea mays)
Liliopsida Zm.3754 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06318 35
  • 58.84 (n)
  • 60.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp22 35
  • 56.84 (n)
  • 56.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for DHX8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHX8 Gene

ENSEMBL:
Gene Tree for DHX8 (if available)
TreeFam:
Gene Tree for DHX8 (if available)

Paralogs for DHX8 Gene

Paralogs for DHX8 Gene

genes like me logo Genes that share paralogs with DHX8: view

Variants for DHX8 Gene

Sequence variations from dbSNP and Humsavar for DHX8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1971 -- 43,525,150(+) GTTTC(A/G)GAACT intron-variant, utr-variant-3-prime
rs14513 -- 43,524,201(+) TGATG(C/T)CCCAG intron-variant, utr-variant-3-prime
rs1319065 -- 43,523,213(+) CAGTA(A/G)AAGGG intron-variant
rs1319066 -- 43,523,167(+) ATCTA(A/G)AACCC intron-variant
rs1382685 -- 43,485,783(-) TACTT(C/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHX8 Gene

Variant ID Type Subtype PubMed ID
nsv833451 CNV Loss 17160897
nsv470588 CNV Gain 18288195
nsv833453 CNV Gain+Loss 17160897

Variation tolerance for DHX8 Gene

Residual Variation Intolerance Score: 2.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHX8 Gene

HapMap Linkage Disequilibrium report
DHX8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX8 Gene

Disorders for DHX8 Gene

Relevant External Links for DHX8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DHX8
genes like me logo Genes that share disorders with DHX8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX8 Gene

Publications for DHX8 Gene

  1. Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22. (PMID: 7935475) Ono Y. … Shimura Y. (Mol. Cell. Biol. 1994) 2 23 67
  2. Characterization of the NTPase, RNA-binding, and RNA helicase activities of the DEAH-box splicing factor Prp22. (PMID: 16008364) Tanaka N. … Schwer B. (Biochemistry 2005) 23 67
  3. The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes. (PMID: 9582286) Wagner J.D. … Abelson J.N. (EMBO J. 1998) 23 67
  4. PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. (PMID: 9769096) Wang Y. … Guthrie C. (RNA 1998) 23 67
  5. Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family. (PMID: 9388478) Imamura O. … Furuichi Y. (Biochem. Biophys. Res. Commun. 1997) 23 67

Products for DHX8 Gene

Sources for DHX8 Gene

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